<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9C8</accession>
    <name>A0A2G1X9C8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="17" type="ORF">BLA24_30400</name>
        <name evidence="18" type="ORF">CYQ11_23495</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47826">
        <property type="protein sequence ID" value="PHQ47826"/>
        <property type="gene ID" value="BLA24_30400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15451">
        <property type="protein sequence ID" value="PPT15451"/>
        <property type="gene ID" value="CYQ11_23495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="16">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="15">
        <location>
            <begin position="143"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ47826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT15451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="261" mass="28298" checksum="8539F066E1C5917E" modified="2018-01-31" version="1">MTTTADSATITAQDRSQNRLDQAHPMNDAAMNAEGQKPARSLPGRPPGIRADSSGLTDRQRRVIEVIRDSVQRRGYPPSMREIGQAVGLSSTSSVAHQLMALERKGFLRRDPHRPRAYEVRGSDQPSTQPTDTTGKPAASYVPLVGRIAAGGPILAEESVEDVFPLPRQLVGDGELFVLKVVGDSMIEAAICDGDWVTVRRQPVAENGDIVAAMLDGEATVKRFKREDGHVWLLPHNAAYQPIPGDEATILGKVVAVLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9H4</accession>
    <name>A0A2G1X9H4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_30720</name>
        <name evidence="11" type="ORF">CYQ11_23815</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47883">
        <property type="protein sequence ID" value="PHQ47883"/>
        <property type="gene ID" value="BLA24_30720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15508">
        <property type="protein sequence ID" value="PPT15508"/>
        <property type="gene ID" value="CYQ11_23815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="624"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ47883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="850" mass="90931" checksum="B316A80354A8363E" modified="2018-01-31" version="1">MGRGNLRIYLGAAPGVGKTYAMLSEAHRRTERGTDVVVGFVEHHGRPRTEVMLHGLEEVPRRELTYRDSCFTEMDVDAVLARRPAVALVDELAHTNVPGSRNTKRWQDVEELLQAGIDVVSTVNIQHLESLGDVVESITGVRQRETVPDEIVRRADQIELVDMSPQALRRRMAHGNIYKPDKVDAALSNYFRPGNLTALRELALLWTADRVDEYLRQYRTDHSVSTIWHARERIVVGLTGGPEGRTLIRRAARMAAKGSGSEILAVYIARSDGLTSASPKELAVQRTLVEDLGGTFHHVIGDDVPASLLEFARGVNATQIVLGSSRRKTWQYVFGPGVGATVARDSGPDLDVHIVTHEEVAKGRGLPVARGARLSRGRTVAGWLVGVGGPALLSLMLTLVVPDLGLANDMLLFLTATVGAALLGGAFPSLASAAFGSLLLNYYFVEPVHQWTITDTKNIVAITIFVLVAISVASVVDVAARRTHQAARLRAESEILSFLAGSVLRGETSLDALLERVRETFGMESVALLERASEVDPWTCASSVVTTDGKPLLRPDDADVEMPVGDNLALALSGRVLPAEDRRVLAAFAAQAAVVLDRQRLVGEAERAQELAEGNRIRTALLAAVSHDLRTPLAAIKAAVTSLRSDDVAWSEEDEAELLAGIEDGADRLDHLVGNLLDMSRLQTGTVTPLIREIDLDEVVPMALGGVPEGSVTLDIPETLPMVAVDPGLLERSVANIVENAVKYSPGGTPVLVAASALGDRVELRVADRGPGVPDSAKDRIFEPFQRYGDAPRGAGVGLGLAVARGFAGAMGGTLAAEDTPGGGMTMVLTLRAAAGRPPVRADLPAQITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Q7</accession>
    <name>A0A2G1X9Q7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31450</name>
        <name evidence="2" type="ORF">CYQ11_24495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47977">
        <property type="protein sequence ID" value="PHQ47977"/>
        <property type="gene ID" value="BLA24_31450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15602">
        <property type="protein sequence ID" value="PPT15602"/>
        <property type="gene ID" value="CYQ11_24495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="85" mass="9387" checksum="F6735BE2EB8692C2" modified="2018-01-31" version="1">MGMQEIDVRRLMEKLGRSGVTVLLKIDEERMAKGGEPWTLLMSGPGVGGLEYIRAESSSLGDCLEQGFAQLRTCPGDWDWLTEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Z1</accession>
    <name>A0A2G1X9Z1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31845</name>
        <name evidence="3" type="ORF">CYQ11_24900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48046">
        <property type="protein sequence ID" value="PHQ48046"/>
        <property type="gene ID" value="BLA24_31845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15672">
        <property type="protein sequence ID" value="PPT15672"/>
        <property type="gene ID" value="CYQ11_24900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="270" mass="28374" checksum="D54CDBF372FD535B" modified="2018-01-31" version="1">MRNSGLSEPYGATGSGGPEGGAAQGDPLERAVWRLRSRACWDDAAALLAPRAATEPGQAVRRTAVLVERCVFTGEGWGAAEDSLRAAEALAADDEERGAAACERGHLAYASTLLGVRDRADEARSALGRAAALLGPQSPTRPLLHFRRGLIAQHLSDNPSDATAAFERAHAGATAHGHRLLLSFTWRHLAAMAEHDGRLAEARHGFAESLRIREDLGYLVGIAPALASLAAVLPDAAEAARLRAEAGRLVRLLGGVPAWLAERLTPAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA15</accession>
    <name>A0A2G1XA15_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ntox27 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48055">
        <property type="protein sequence ID" value="PHQ48055"/>
        <property type="gene ID" value="BLA24_31895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029112">
        <property type="entry name" value="Ntox27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15531">
        <property type="entry name" value="Ntox27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00394">
        <property type="entry name" value="RHSPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ntox27" evidence="2">
        <location>
            <begin position="113"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="284" mass="31854" checksum="3046D430EEBC593D" modified="2018-01-31" version="1">MGAPRELLDENGDVAWRTRTTLWGLTTWNRTATAYTPLRFPGQYFDPETGLHYNRFRHYDPETARYLSVDPLGLLPAANARTYVHNPVMWIDPLGLAGCPHRENNDQTHSVVLGANPPSDNLARHLRENGDPGAHTYNGDDYAGDVNGSPVWMTNVMAAVGDRNTRLSVTLDDMANAAGERGNWNTPESIAEAFQVAVQRGEPFGVGPGQPRPPTGYGTAWEMSVIARNVRVYNADPDLGGRSWDSIEWYSNNQRVHVPQPDIPELQPGYRPDQQNEHHRRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAG2</accession>
    <name>A0A2G1XAG2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBS lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32560</name>
        <name evidence="2" type="ORF">CYQ11_25610</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48159">
        <property type="protein sequence ID" value="PHQ48159"/>
        <property type="gene ID" value="BLA24_32560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15785">
        <property type="protein sequence ID" value="PPT15785"/>
        <property type="gene ID" value="CYQ11_25610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="212" mass="22859" checksum="6B6C85EA2417E213" modified="2018-01-31" version="1">MEEEFRALLKRIRAELASSAEHAAYEALLALVRADGPAARDELAEVLVAPERPLWAREIAAFALGVKGDRRAFETLVLLLNYREPVRCATAAHALARLRDPRTARAAAALATNPLRTAYAVHPVRLLTELRAPESVPALLSTLERLLAARDHCWPVARACVEGLGVLGDRRAEATLVAAREHERLRPAALVALARLTGRGGGPHGVRSGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAH9</accession>
    <name>A0A2G1XAH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32970</name>
        <name evidence="2" type="ORF">CYQ11_26020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48230">
        <property type="protein sequence ID" value="PHQ48230"/>
        <property type="gene ID" value="BLA24_32970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15857">
        <property type="protein sequence ID" value="PPT15857"/>
        <property type="gene ID" value="CYQ11_26020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="30731" checksum="16731690F6D3F3E0" modified="2018-01-31" version="1">MTTLPARAGRRCHYVVNALHSVVYFSPDNEREMSALGITDRSALYFAGRAAALGRVGAGTVTATFHSFSHELVARHVPHIWDVASPEDVLAARLRVADATLRRLLGEEALASAEMAEAAGLALRAAEACERPVRPLYAAHADLPVPHAPHLALWHAATLLREHRGDGHLIALAGSGLDPLEALVSHSATGRGMSTKWLLATRGWSEEELTAARLRLRERGLLDERDALTDAGAALREEIEEETDRLDAAPYEHLGAEGVGRLTELATAFATTLVENGGYPADLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAQ6</accession>
    <name>A0A2G1XAQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33155</name>
        <name evidence="3" type="ORF">CYQ11_26205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48259">
        <property type="protein sequence ID" value="PHQ48259"/>
        <property type="gene ID" value="BLA24_33155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15890">
        <property type="protein sequence ID" value="PPT15890"/>
        <property type="gene ID" value="CYQ11_26205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="244" mass="25723" checksum="AFB05638CA3A40C2" modified="2018-01-31" version="1">MPNGRGLWDQFGTRGLSAAVGEVAAEGGAGQVDRPAVGVQVPLSSGALPSVKCSFRSRAAVAMRVRAEVTVPERTGGGIRLAMYRSMLRDHRSEAMRRASLLGAAARQSSWVVRESRRSESVRVVPSTVNDQKVHPSTRSSPAAIRAADVGVFQGRWKHMILPSASRVALAGPRFPRPVNAIPPAENASGGRAATRVLRSTRWLATAAAGGSDPPLVPSATPPLAPPSEGESSPERSWARQPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAR0</accession>
    <name>A0A2G1XAR0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_33510</name>
        <name evidence="6" type="ORF">CYQ11_26560</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48318">
        <property type="protein sequence ID" value="PHQ48318"/>
        <property type="gene ID" value="BLA24_33510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15950">
        <property type="protein sequence ID" value="PPT15950"/>
        <property type="gene ID" value="CYQ11_26560"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="393" mass="41335" checksum="74DB41FDEDB08AEE" modified="2018-01-31" version="1">MTAIDLSSPSDSGRNQESGLWPCPPAGPQSGWSEPAALAAGKEQGFHPPLVFAAECDQLRSRLAAVARGEAFLIQGAVSADEFALEFTEAIDVALKTLLQMSSVLSYAMAVPVVRIGRIASSAFETREHRTAAAALNLARGLLRAGYADIALVHEWNRDFVATGGGRRYGPIVSEMGGALRFMAACGVNAAQWGAEFFAGREMSVPDDEGAPRSVGVLGEAHDGAFREEVHQASTHMVWVDRSDSASVELASRVSNPIGVRIGSSTTPDEVLALLEHLDPDRAPGRLTFLAGMGAESVRDVLPDLIGKVAASGALPVWVCDPLCRSAGRLDAACGEVRDFFEVHRELGTRPGGLCLDPTGGSAFLREQLLELAFSVAEMCPGMPRAAADAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAT4</accession>
    <name>A0A2G1XAT4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">BLA24_30900</name>
        <name evidence="11" type="ORF">CYQ11_24000</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48333">
        <property type="protein sequence ID" value="PHQ48333"/>
        <property type="gene ID" value="BLA24_30900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16757">
        <property type="protein sequence ID" value="PPT16757"/>
        <property type="gene ID" value="CYQ11_24000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="30636" checksum="40FA1EC08368F309" modified="2018-01-31" version="1">MPFAKGHGCQNSFLLLPDPAGRLDLTTDEIRRLADTHTGAGADGILRVVRCTAAPEAVAMAGTAEWFMDYRNADGSLGAMCGNGIRLFARYLVDAGHCSPGTLAIATRAGVRHVRVPPASDGAQGQVSVVMGSPAFPGPDHITLVAAGRRWPATHVDMGNPHAVVFVDDLADAGTLHVPPIAEPADAYPHGFTTEFVAVRGPGHLALRVHERGVGETRACGTGACAAVAAHRRRAHDTRAADYRVDLLGGRLHVAVAGDGTMTLAGPAVITAHGVIGLPGSEERTDPLSKLEGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX0</accession>
    <name>A0A2G1XAX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32435</name>
        <name evidence="3" type="ORF">CYQ11_25485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48370">
        <property type="protein sequence ID" value="PHQ48370"/>
        <property type="gene ID" value="BLA24_32435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16796">
        <property type="protein sequence ID" value="PPT16796"/>
        <property type="gene ID" value="CYQ11_25485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="38292" checksum="4BADD3CAB087607A" modified="2018-01-31" version="1">MIQAGVAHWIDDTTGIAKASELAVALVALTDFAAVWWFAVALHSAGHPTPAWLRRAPAVCAGTMAALAVVFFALAPAADRFGARAHGWWVPYAVAWIGYGLITAVGAGALFWRHGVTMRSPVLRLSMLALAVGTTAEVPYLVIRAIRWFTEAPQELALAGFWCSFTRFVLVALGCSLAALEPLRRAAVYWYRRQRLHGMWILLRQATPDLLVVAPRSRVPDLLAFGDSWEQLHQRVVDIRDSITFLHDGWASPELLREAARHAAAATGGDGGRLVATACWIEATRRDAVRGAPKLHLELDKDLLPEVRAGESTVHREIRHLLRLHRALRSRPVRAFADARPWATPGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX6</accession>
    <name>A0A2G1XAX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32160</name>
        <name evidence="6" type="ORF">CYQ11_25215</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48361">
        <property type="protein sequence ID" value="PHQ48361"/>
        <property type="gene ID" value="BLA24_32160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16787">
        <property type="protein sequence ID" value="PPT16787"/>
        <property type="gene ID" value="CYQ11_25215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304686" evidence="4">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="135" mass="14314" checksum="BBC266EF83D0AAE1" modified="2018-01-31" version="1">MNTPQRFARLGALAVIASTLLIGTPAVAATPTVHPAAAVKSVGDVCLSALPSQAHDTIRLIDAGGPFPYPKDGTVFTNREGVLPQHTSGYYHEYTVITPGSPDRGARRVVAGQGAHEDYYTGDHYETFDLVDFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB13</accession>
    <name>A0A2G1XB13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32405</name>
        <name evidence="5" type="ORF">CYQ11_25455</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48369">
        <property type="protein sequence ID" value="PHQ48369"/>
        <property type="gene ID" value="BLA24_32405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16795">
        <property type="protein sequence ID" value="PPT16795"/>
        <property type="gene ID" value="CYQ11_25455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304815" evidence="2">
        <location>
            <begin position="29"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="68"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="32972" checksum="3E5B75A86525D1E8" modified="2018-01-31" version="1">MSLPHRRGPRAAAALALAGLALLAAACGKEGSPPVKGPKPEQLPVYQVATGFQLPDSPTWRGARRRGHLVVGAKEDQPYLGEKDPATGRYSGFDIEIAKMLSASLGFDPKTLSFRTIASANRETALQNGQIDYYVGTYTINDLRKKQVGFAGPYFMAGQSLLVRKDQKGVEGPQDLAGQRVCSASGSTPLQRIQRDYPKIHAVAYDTYSICVDNLLSLQVSAVTTDNTILMGFAAKAPDELKVVGQPFSKEPYGIGVPRGDTALRFALDDALAAHEKNGDWKKAYDATLGLSGVPAPQPPAIDRYPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB76</accession>
    <name>A0A2G1XB76_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2165 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29355</name>
        <name evidence="3" type="ORF">CYQ11_06120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48472">
        <property type="protein sequence ID" value="PHQ48472"/>
        <property type="gene ID" value="BLA24_29355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12530">
        <property type="protein sequence ID" value="PPT12530"/>
        <property type="gene ID" value="CYQ11_06120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018681">
        <property type="entry name" value="DUF2165_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09933">
        <property type="entry name" value="DUF2165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="19237" checksum="E91FFC77B55BB060" modified="2018-01-31" version="1">MHGLMSSERTLPVAATALTATVAVYTALVAFGNVTDFGTNREFVRHVLAMDTTFLDDDLMWRAVTDRTLQDAAYVAVIVWETVAALALLWATALWLRGLVRPWAGYGPARRASTVGLVMLMLLFGLGFMAIGGEWFAMWQSTKWNGLQAAGRDFTLAGFVLVLIHLPSSQWRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB89</accession>
    <name>A0A2G1XB89_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29180</name>
        <name evidence="3" type="ORF">CYQ11_06295</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48449">
        <property type="protein sequence ID" value="PHQ48449"/>
        <property type="gene ID" value="BLA24_29180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12555">
        <property type="protein sequence ID" value="PPT12555"/>
        <property type="gene ID" value="CYQ11_06295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="320" mass="33687" checksum="F9487AE50754F2B8" modified="2018-01-31" version="1">MVSGAVRRIHPPEPRYSPYAPPPPPRGAPVKSRRRSWRSLPTLLSALALAVTAAVVPQAAAAATAPVVSSGWNDYSCKPSAAHPRPVVLVHGTLENSTNNWWSFAPYLARRGYCVFSLDYGRLPGVPYFGGLGPVAASAGELAVHVDKVLKATGAAKADLVGHSQGGMLPRYYTKFLGGAPKVNAIVGIAPNNHGTTLSGLTGLLNVVPGARDAIRGTAPGLTDQVVGSEFMRKLNEGGDTLPGIRYTVIATRWDEVVTPYRTQFLSGPGVRNVLVQDLCPVDISEHLALGTIDRIAFHEAAGALDPEHATPANCATLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBB4</accession>
    <name>A0A2G1XBB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29730</name>
        <name evidence="2" type="ORF">CYQ11_05745</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48534">
        <property type="protein sequence ID" value="PHQ48534"/>
        <property type="gene ID" value="BLA24_29730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12466">
        <property type="protein sequence ID" value="PPT12466"/>
        <property type="gene ID" value="CYQ11_05745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="65" mass="7096" checksum="51765CDA5A56AFF3" modified="2018-01-31" version="1">MFWPMLAIALGFCGTAVLGILAVRVFAEVRRLSREVAEASRRITRAAEDLERAATPLAAQLPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBG1</accession>
    <name>A0A2G1XBG1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29950</name>
        <name evidence="3" type="ORF">CYQ11_05520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48573">
        <property type="protein sequence ID" value="PHQ48573"/>
        <property type="gene ID" value="BLA24_29950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12425">
        <property type="protein sequence ID" value="PPT12425"/>
        <property type="gene ID" value="CYQ11_05520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="8579" checksum="BC4A95BBBA854CB1" modified="2018-01-31" version="1">MKSLLNVASFVLIAGGASGLLHEWLGWFRLFGFLRWLSPDGYEVYTYVVLVALGVVLGAVNASLTREPSATGASRQGPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY5</accession>
    <name>A0A2G1XBY5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="7" type="ORF">BLA24_28580</name>
        <name evidence="8" type="ORF">CYQ11_06885</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48736">
        <property type="protein sequence ID" value="PHQ48736"/>
        <property type="gene ID" value="BLA24_28580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16391">
        <property type="protein sequence ID" value="PPT16391"/>
        <property type="gene ID" value="CYQ11_06885"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="283"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="480" mass="49804" checksum="BED25B9C715E2478" modified="2018-01-31" version="1">MSTRLPRLVIAAPASGSGKTTVATGLMRAFADAGLAVSPHKVGPDYIDPGYHALATGRPGRNLDSFLCGPERIAPLFLHGAAGCDLAIVEGVMGLYDGAAGQGELASTAHVAKLLRAPVVLVVDASSQSRSVAALVHGFASWDPEVRVAGVILNKVGSDRHEALLREALDESGVTVLGAVRRAEPVHTPSRHLGLVPVAERRAEAVDAVAEFAARVREGCDLERLLALARSAPPVTGEAWSARGEPLPHPVPSPNRGSAPDPASQTPERPDEGADPNRGRPVIAVAGGPAFTFSYAEHAELLRAAGAEVVTFDPLRDEALPERTAGLVIGGGFPEVYAPELSANEPLRKAVAELAFAGTPVAAECAGLLYLSRALDGKPMCGVLPADARMSERLTLGYREAVAIADNPLAAAGTRVRGHEFHRTVVEPAAGAVPAWGITRPARRVEGFAQGGVHASYLHVHWAGAPGTAERFVAAAADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY9</accession>
    <name>A0A2G1XBY9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="13" type="ORF">BLA24_27195</name>
        <name evidence="14" type="ORF">CYQ11_18460</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48767">
        <property type="protein sequence ID" value="PHQ48767"/>
        <property type="gene ID" value="BLA24_27195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14585">
        <property type="protein sequence ID" value="PPT14585"/>
        <property type="gene ID" value="CYQ11_18460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="157"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ48767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="329" mass="34702" checksum="51BB63F4379C1EC2" modified="2018-01-31" version="1">MTRTPVNVTVTGAAGQIGYALLFRIASGHLLGADVPVKLRLLEIPQGLKAAEGTAMELDDCAFPLLRGIEITDDPNVAFDGANVGLLVGARPRTKGMERGDLLEANGGIFKPQGKAINDHAADDVKILVVGNPANTNALIAQAAAPDVPAERFTAMTRLDHNRAISQLAKKTGVAVSEIKKLTIWGNHSATQYPDIFHAEVAGKNAAEVVNDEQWLADTFIPTVAKRGAAIIEARGASSAASAANAAIDHVHTWVNGTAEGDWTSMGIPSDGSYGVPEGLISSFPVTVKDGKYEIVQGLEINDFSRARIDASVKELEEEREAVRGLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCI6</accession>
    <name>A0A2G1XCI6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01150</name>
        <name evidence="2" type="ORF">BLA24_22950</name>
        <name evidence="4" type="ORF">CYQ11_23125</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000013">
        <property type="protein sequence ID" value="PHQ53418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48967">
        <property type="protein sequence ID" value="PHQ48967"/>
        <property type="gene ID" value="BLA24_22950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53418">
        <property type="protein sequence ID" value="PHQ53418"/>
        <property type="gene ID" value="BLA24_01150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15388">
        <property type="protein sequence ID" value="PPT15388"/>
        <property type="gene ID" value="CYQ11_23125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="91" mass="10340" checksum="8731B7F411B551DC" modified="2018-01-31" version="1">MEITYSGVIEAAGQVKSTADTIHTQLQDLNARVLEAVSHWDGETRQAFHERHRNWDNNVDHMHNTLLDIAKAMKQAAHDYKANDKAQAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCK1</accession>
    <name>A0A2G1XCK1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22865</name>
        <name evidence="4" type="ORF">CYQ11_23210</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48952">
        <property type="protein sequence ID" value="PHQ48952"/>
        <property type="gene ID" value="BLA24_22865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15403">
        <property type="protein sequence ID" value="PPT15403"/>
        <property type="gene ID" value="CYQ11_23210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="20010" checksum="C021EE84B45B9526" modified="2018-01-31" version="1">MPLPFLTADRDSDDLATTTAAPLPHEDPYESRDRWRRPYRPGPARVGGAALLLLLAAYVLCSAAIVAVAGSLPATGVCVAVAALLITLAVRLVRLGIWVGPRGLRQSGLLSGTTLSWSEVAEVRTVQQPVRLLGTPRTVQGQALVVRRTQGEPLAVLVTDHNADFVGRPMAFAMAADAIEDWVAELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCU2</accession>
    <name>A0A2G1XCU2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">smc</name>
        <name evidence="9" type="ORF">BLA24_23385</name>
        <name evidence="10" type="ORF">CYQ11_22690</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49038">
        <property type="protein sequence ID" value="PHQ49038"/>
        <property type="gene ID" value="BLA24_23385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15316">
        <property type="protein sequence ID" value="PPT15316"/>
        <property type="gene ID" value="CYQ11_22690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758401" description="Chromosome partition protein Smc" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="8">
        <location>
            <begin position="512"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="943"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="727"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="975"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1188" mass="128217" checksum="B338D51E6B86B425" modified="2018-01-31" version="1">MHLKSLTLRGFKSFASATTLRFEPGITCVVGPNGSGKSNVVDALSWVMGEQGAKSLRGGKMEDVIFAGTTGRPPLGRAEVSLTIDNSDGALPIDYAEVTITRIMFRNGGSEYQINGDTCRLLDIQELLSDSGIGREMHVIVGQGQLDSVLHADPTGRRAFIEEAAGVLKHRKRKEKALRKLDAMRANLARVQDLTDELRRQLKPLGRQAAVARRAAVIQADLRDARLRLLADDLVTLREALRSEIADEAALKARKEAAEAELRTAAQREAALEEQVRELTPRLALAQQTWYELSRLAERVRGTISLADARVTSATTAPAEDRRGRDPEDLEREAARVREQEAELEAALEAASRALEDTSQHRADLERRLAEEERRLRDAARAAADRREQLARLHGRVTAARGRAASAEAEIGRLAAARDEAAERAAAAQEEYERHQAEADGADADDAELAAAHDRAKAELAAAQAALDDAREAATEAERRRAAVTARHDALALGLRRKDGTGALLSAKERLGGLLGPAAELLRVTPGHELPVAAALGAAADALAVTGPVAAAEALRLLKKEDAGRATLLLAGAPDVPAPPADGRATPAAHLVRGPDELMPAVRRLLRDVVVVDTLEDAEHLVMTRPGLTAVTAEGDLLGAHFAQGGSGGAPSLLETQAAVDEAAAELTGLDARCTELRARQDAAKERRRAAATLVDELAARRSTGDREKSRAAQTLGRLAGQARAAAGEAERAAAAAQRAGEALERATEEADELAERLAAAEELALADEEGTDEPDTSVRDRLAADGANARQTEMEARLAVRTHEERVKALAGRADGLDRAARAEREARARAEQRRTRLRHEAEVAAAVAAGARQLLAHVEASVVRADGERREAEAAKAERESELIAGRNQARDLKAELDKLTDSVHRGEVLGAEKRLRVEALETKALEELGVEPTALVAEYGPDQLVPPSPPAEGEELPDDPDHPRNRPVPYERAAQEKRLKAAERAYQQLGKVNPLALEEFAALEERHKFLSEQLEDLKKTRADLLQVVKDVDKRVEEVFTAAYHDTAREFEGVFSRLFPGGEGRLVLTDPDDMLATGVDVEARPPGKKVKRLSLLSGGERSLTAVALLVAIFKARPSPFYVMDEVEAALDDTNLQRLIGIMKELQESSQLIVITHQKRTMEVADALYGVSMQGDGVSKVISQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ2</accession>
    <name>A0A2G1XCZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23835</name>
        <name evidence="4" type="ORF">CYQ11_22235</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49113">
        <property type="protein sequence ID" value="PHQ49113"/>
        <property type="gene ID" value="BLA24_23835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15239">
        <property type="protein sequence ID" value="PPT15239"/>
        <property type="gene ID" value="CYQ11_22235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="46"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="152" mass="16022" checksum="C92157635CE69367" modified="2018-01-31" version="1">MSDTNDENTTAGPSGRTSFDRGMEMLRQVVGEGGQKAVDSLADVSPELGRQVVSWGFGEIYARPQLAPRDRQLVTLGMLTALGGCEPQLEVHVNAALNVGLSPEQVVEALLHSAAYCGFPKALNATYVAKKVFAERGLLPLPDGSAPRADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD23</accession>
    <name>A0A2G1XD23_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_23760</name>
        <name evidence="10" type="ORF">CYQ11_22315</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49101">
        <property type="protein sequence ID" value="PHQ49101"/>
        <property type="gene ID" value="BLA24_23760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15253">
        <property type="protein sequence ID" value="PPT15253"/>
        <property type="gene ID" value="CYQ11_22315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758469" evidence="7">
        <location>
            <begin position="30"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="44"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="463"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="731" mass="75498" checksum="199F54CA858AEE9B" modified="2018-01-31" version="1">MTSLARWCLRRRFAVIVLWLLALAGTAAAATCAGKTYTDDYAVPGTESTRATALLEKAFPGEGGDDKIVWHTDRGTVRAAVVEQRMTATLREIAHLPGVDSVTSPYGSEGAHQISRDRHTAYASVAFASATGDPDKAQVKRVVDTARAASDDNLAVALGGTGVGAAEAPGGHLSEIIGVAVAAVVLLVVFGSLAASLLPIATALVGVGTASMGTVLLGHVMNVAEFAPMLGTLIGLGVGIDYALFIVTRHRKGLRQGLPVAIAAERAVATTGRAVVFAGGTVCVALLGMLILRLGFLNGVAIAASLTVVLTVAASVTLLPALLGVIGDRALSRRERRRLALGPRPEAPAGLAARWAAFVERHPKLLGAAAATVMLTLALPTLSLHLGTSDQGNSPASSTTRQAYDMLAEGFGPGVNGPLTLVAPLDGAADRLAFNRLPDTLRHIPGVAAVTPSALNASGDAGVITVVPMTSPQSAATSELVERLRTSVLPRATGGTGPTVHVGGMTAGYDDFAGVILGKLPLFVGTVVGLGCVLLLLAFRSIGIPLKAAAMNLAAVASSFGLIVAVFQWGWGSETLGLGAAGPVEPFLPVVMVAVLFGLSMDYQVFLVSRMYEEWLATRDNRRAVRVGLAETSRVINSAAIIMISVFLAFVLSGDRVIAMFGIGLAAAVALDAFVLRTLLVPALMHMLGGANWWLPGWLERWLPRISIEPAEHAPLPPPVAAPVPPVPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD54</accession>
    <name>A0A2G1XD54_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49152">
        <property type="protein sequence ID" value="PHQ49152"/>
        <property type="gene ID" value="BLA24_24090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="65" mass="6765" checksum="DC7C84AC80677857" modified="2018-01-31" version="1">MHAPSGTPLADIVHAAGARWAIEETFQAAKNEAGLDPLPDPPLPPPRSPTPVTARLTTLVLTGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD84</accession>
    <name>A0A2G1XD84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24310</name>
        <name evidence="3" type="ORF">CYQ11_21760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49193">
        <property type="protein sequence ID" value="PHQ49193"/>
        <property type="gene ID" value="BLA24_24310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15157">
        <property type="protein sequence ID" value="PPT15157"/>
        <property type="gene ID" value="CYQ11_21760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="341" mass="36333" checksum="6B606E80D8316FBD" modified="2018-01-31" version="1">MRVGAFVLAAQFPGQGHEEALYRAVRSAEVAEEAGLDAVWLAEHHFVPYGVCPSAVTLAALLLGRTRALRVGTAVSVLPTTHPVTLGEQAALLHLTSGGRFTLGVGRGGPWVDLEVFNSGLGAYEEGFPESLELLMRWLREPRVGSSSERFAFREVPVVPRPDELLDSAGPEVIVACTSPASVRLAAAQGLPMLLGMHSADEEKAEMVALWRKCALEAGSSPEAVAAAGHVSAGVVQIADRRQEAAETLLKTMPGWLHHGLSAHVTVDGRLRRMRDPLAYTELLCELHPVGSPRLCADRLAATAERTGISRFALLAEGSGDLAATEENLRRLGADVLPLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDA7</accession>
    <name>A0A2G1XDA7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ORF">BLA24_24470</name>
        <name evidence="9" type="ORF">CYQ11_21600</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49223">
        <property type="protein sequence ID" value="PHQ49223"/>
        <property type="gene ID" value="BLA24_24470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15126">
        <property type="protein sequence ID" value="PPT15126"/>
        <property type="gene ID" value="CYQ11_21600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="8042" checksum="7B1053DF21B64D19" modified="2018-01-31" version="1">MKRDIHPEYVETQVSCTCGASFTTRSTIDGGVIRAEVCSACHPFYTGKQKILDTGGRVARFEARFGKNAGSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDI0</accession>
    <name>A0A2G1XDI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24655</name>
        <name evidence="4" type="ORF">CYQ11_21415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49255">
        <property type="protein sequence ID" value="PHQ49255"/>
        <property type="gene ID" value="BLA24_24655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15093">
        <property type="protein sequence ID" value="PPT15093"/>
        <property type="gene ID" value="CYQ11_21415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045450">
        <property type="entry name" value="VMAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20028">
        <property type="entry name" value="VMAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VMAP-C" evidence="2">
        <location>
            <begin position="585"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="857" mass="91733" checksum="AA2F2A3C96A0AED1" modified="2018-01-31" version="1">MARGWRNRSSAPGRRHGGLGADHGGAGAPGAAWGCVRRLRRSGRPRRVRGLQCRPARGGRRQRPRRRRARRRRVPAHGARGGAAGRGAGRLRDRAVRPGGTGDRPARGRQRQGVDHGLADLVRAGGAGPAAARPRRPHDPRRSLSALDGTARRAVVRISAPGGGYDRSGARFWGSGFFIAPGWVLTCAHVVGNGGGDVLGGVTGIDITDWRDRTTEGRVALALPRPPDPDAPPRRWPLPDLALVEVADAEDAECLWLSDRSAVVPAPVSLHGWSQETGELALRFGLGTASGGDGSDGSAMLLRGEIPVAGCSGGPVVDTGRGAVIGVSKGRGHDTAGLAVPVTALRRIADDGPGRDRLHSIISAHDRHHLRRYRTMGTGGSWTGLQQALRPPRADGFTPVLRTHLFARLAELTQPRTPGEVMLLVGHAKRRVIQAPYQPGVEHDPRTWREGVGLLYDLRDGGRTKETGPDRDLELEAVLLYAARVAAAVSRLGEGRDVAPLRELSTWLAGQAESLPDVIREEIHQILHGGSAGPAEPREPAPPGTVELRKPERRDVEPGAPGAAEGRARADVIVEVDPLLYGSCYPWRVKLLLEDGVVTPLAGDERGVPRARLREALREPIARALRQGDVGEHLAEVQVVLPRELFDEPLDAWRLTAPDAPGGGIDPHTMPLGQRRVVVVRDRRRRDHPAIPEWHRRWSGTSRGPLTVVPLRREAPERGHGGAGRESGHAAYGRLSDAADSAVPVYCGEVAGGAGAMAMEAALAAGHPVVIWRRCATGHTDCAEFHHEIARLVGEAGTADGLHRRIRNLRIRCGDPDAPDPEVLWARSIAVLFDSPDHPPLPDTPLYVPGAGWGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDK7</accession>
    <name>A0A2G1XDK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_25045</name>
        <name evidence="5" type="ORF">CYQ11_21025</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49323">
        <property type="protein sequence ID" value="PHQ49323"/>
        <property type="gene ID" value="BLA24_25045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15029">
        <property type="protein sequence ID" value="PPT15029"/>
        <property type="gene ID" value="CYQ11_21025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="387" mass="41558" checksum="7F424C896043B2B2" modified="2018-01-31" version="1">MSSPDREADREVRAARNGSARESTTPSRLPLGGSRSGRRPVVVVTGAARGVGALLTRRLAESEEIKQVVAIDERRGDVTEAQWHVLDVRDPAIAEKLRGADVVVHLAIDLDLETDAAARTAYNVRGTQTVLTAAAAAGVHRVVLCTSAMVYGAHPDNDVPLAEDAELRATAEATGVGDLLEIERLARRAPRAHPGLNVTVLRPAILVGGTDTALTRYFESPRLLVVAGSRPTWQFCHVEDLVSALEFAALEKAEGELAVACDGWLEQEEVEELTGIRRMELPSAVALGAASRLHRLGLTPSPAGDLEYTMHPWVVSGHRLHDAGWRPRWTNEEVLAELLEEVAGRHTVAGRRLGRKDATAAGAAGATVALLGTAALVRRARKARRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDN9</accession>
    <name>A0A2G1XDN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modA</name>
        <name evidence="5" type="ORF">BLA24_25155</name>
        <name evidence="6" type="ORF">CYQ11_20915</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49342">
        <property type="protein sequence ID" value="PHQ49342"/>
        <property type="gene ID" value="BLA24_25155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15010">
        <property type="protein sequence ID" value="PPT15010"/>
        <property type="gene ID" value="CYQ11_20915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304730" evidence="4">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="26771" checksum="CA95DC3D0FC4609E" modified="2018-01-31" version="1">MPRTAPRRLPAVLAAVLVLPLAAACDGDRKDSGSGAKERTTLTVLAAASLTDVFKQAGAAYEKEHPDTKVTFSFAGSQELAAQVRQGAPADALVTADTKTMDGLAKETGTPGVIAKNRLTIATAPGNPKKVEGLADLSKADLKVVLAAPEVPVGRYSKQVLDQQHVAVKPVSQEPNVRAVLGKVSMGEADAGIVYLTDAAAAKGKVATVAIPDDQNAVASYPAATLKGSKHAGEAADFVRWLASDEARKLLLSAGFQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDU8</accession>
    <name>A0A2G1XDU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_25445</name>
        <name evidence="9" type="ORF">CYQ11_20630</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49392">
        <property type="protein sequence ID" value="PHQ49392"/>
        <property type="gene ID" value="BLA24_25445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14958">
        <property type="protein sequence ID" value="PPT14958"/>
        <property type="gene ID" value="CYQ11_20630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="247" mass="26774" checksum="4DA071893CEDE00A" modified="2018-01-31" version="1">MNTLIKLEITRTLRNKKFMFFSVIYPAALYLMIAGGASTSEVVEGTGLTLPLLMMVSMASFGAITAVLVGNSERIAKEREKGWVRQLRLTSLPGRGYVTAKVASAAVVSLPSILVVFVVAATVKDVRFDGVWQWFALTGVIWAGSIVFAALGVAVGYLATGDAVRPITFIIYFGLSMLGGLWMPTAVFPKWLQNIAEWVPTHAYAALGQAIEVGDAPHLKDVAILFVYLLLFSGAAAWLYRKDTHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE31</accession>
    <name>A0A2G1XE31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25965</name>
        <name evidence="3" type="ORF">CYQ11_20100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49486">
        <property type="protein sequence ID" value="PHQ49486"/>
        <property type="gene ID" value="BLA24_25965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14863">
        <property type="protein sequence ID" value="PPT14863"/>
        <property type="gene ID" value="CYQ11_20100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="32958" checksum="0B0CA7D5CB18D669" modified="2018-01-31" version="1">MRAIVIARPGGPEVLQVQEVPAPAPIAGHHVVKVSRAGVNYADIHLRENGYLTPVEYPVTPGNEVMGTLADGRRVVALSRGGGYAEQALAHRAVTWEVPDEISDEQAVALALQGQSAWHLLHTVLQLGKGDSILIPAAAGGVGSLAVQLAKAAGARVIAMAGSPEKADLVRSLGADAVLDSSTHQDLTARILDANEGPVTRALEMTGGEVFDATLAALAPRGHMAVYGCVSGDQREAPVAQLMQASKTVSGFWLPNLYGVRYALRDSMKALFEATARGDLRPVIGPCYALSNAAQAHSDLGSRKTTGKVTIKTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE83</accession>
    <name>A0A2G1XE83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26275</name>
        <name evidence="4" type="ORF">CYQ11_19365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49538">
        <property type="protein sequence ID" value="PHQ49538"/>
        <property type="gene ID" value="BLA24_26275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14742">
        <property type="protein sequence ID" value="PPT14742"/>
        <property type="gene ID" value="CYQ11_19365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20242" checksum="3ED7FA7F93587393" modified="2018-01-31" version="1">MSSPTAHSSGEATGPPGAGGPAAGPVDAAADAAAQGGEPSAAPAGAEGASARAERRNDAWERLLHWLFFSVLLAVMPIGAGVLVDLTRKQNRPFFELISHGDLYIVSTGLTATAVGDALMRQKERFRPLQLVLAFTNIAICLLTCILYADIGAATQDGKELDHQFLGEMSLVFFAITLVTTGSSTFLNELEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEA4</accession>
    <name>A0A2G1XEA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SMI1/KNR4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26260</name>
        <name evidence="2" type="ORF">CYQ11_19380</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49535">
        <property type="protein sequence ID" value="PHQ49535"/>
        <property type="gene ID" value="BLA24_26260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14745">
        <property type="protein sequence ID" value="PPT14745"/>
        <property type="gene ID" value="CYQ11_19380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="182" mass="19027" checksum="33472DFA6372ACC8" modified="2018-01-31" version="1">MTDKTGADRRFPPALADAARTSFSYGEDGVGIDFEPYDAFDSAEETTGWLRQWTGNPAVDGDAYRVFGQDGAGGLVALWCARPGRPLTEQPVVYIGSEGECGVVAGDLSGFLWVLADGFGPMAAALYGAGEADEAHETGPGAAPAELAARHATTPRRPAREIVAEAQAEFPAFAEGLCALCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI9</accession>
    <name>A0A2G1XEI9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26885</name>
        <name evidence="3" type="ORF">CYQ11_18750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49643">
        <property type="protein sequence ID" value="PHQ49643"/>
        <property type="gene ID" value="BLA24_26885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14635">
        <property type="protein sequence ID" value="PPT14635"/>
        <property type="gene ID" value="CYQ11_18750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="30421" checksum="DEA69665441F692A" modified="2018-01-31" version="1">MAKDLGAQGPSIARQAYGEELRLRREAANHTQQSLADTVVCSPSLIAHIEAGRRKPRVEDARRLDKELGTDGFFERFLPTLSPSRFAGHFAPLVEMEKQATSIREHGSGLVPGLLQIEPYARAIFRFGLVNMTAAEVDRRVAQRLERSHILEGPDGPVMWVLLDEHVLRRVVGGPAVMAAQLRHVAKLADSGRIRLHVLPFSIGSHALVASSMSLYRFDDAPPLAYVEGVKTGHMYDEPSRVAQCQAAYELALGDALSCHASLSMINAVAEEYEHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XER7</accession>
    <name>A0A2G1XER7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_24700</name>
        <name evidence="7" type="ORF">CYQ11_21370</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49720">
        <property type="protein sequence ID" value="PHQ49720"/>
        <property type="gene ID" value="BLA24_24700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16708">
        <property type="protein sequence ID" value="PPT16708"/>
        <property type="gene ID" value="CYQ11_21370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="297" mass="32505" checksum="BB40DF3B6F507E3E" modified="2018-01-31" version="1">MPDAIKAIPVRHYGRWVSAVVVLALLGLLVNAFASANVHYSAIPDYLFDSTVISGLGKTVLISVLSMVLGLALGIVLAVMRLSKNPVTSSVSWLYIWFFRGTPVYVQLLLWFNLALIFPYINLGPIYRDEMSDFMTPFMAALLGLGLNEAAYMSEIVRAGIQSVDEGQTEAAHALGMSQGRTLRRIVLPQAMRVIVPPTGNEFINMLKTSSLAASAAQYLELLRSTSDIGQTTGATVEMLFLAATWYLILTSVFSVGQFYLERHYARGSLRTLPLTPFQKIKKNLASFSRQSGGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XET2</accession>
    <name>A0A2G1XET2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26975</name>
        <name evidence="3" type="ORF">CYQ11_18660</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49764">
        <property type="protein sequence ID" value="PHQ49764"/>
        <property type="gene ID" value="BLA24_26975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16656">
        <property type="protein sequence ID" value="PPT16656"/>
        <property type="gene ID" value="CYQ11_18660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="261" mass="27167" checksum="DF88132403AEC628" modified="2018-01-31" version="1">MAHIPTPLHTTVHGSGPGILLAHGAGGSIEGNFAPVIPALSERHTVVAPDYPGSGATPRATGPLTVDALSDGIVAAADAAGLETFTLVGYSLGTLVSVRTAARHPERVRGLVLTAGLAKPDNRADASLFLWQRLLAEGDLQAFARLTALSAFGEDFFNAVPEAEREAFYDALAQGVPAGAAEQAGAVRSGDTTADLAGIRVPTLVIATTKDTLVSPANSRYLVDHIPGAEYAEIETGHVPMAERPEEWQKLILDFLGRHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEU2</accession>
    <name>A0A2G1XEU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49725">
        <property type="protein sequence ID" value="PHQ49725"/>
        <property type="gene ID" value="BLA24_24930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="386" mass="40181" checksum="102C4376ABCE0981" modified="2018-01-31" version="1">MAWTAWRGVAQPHVALAYGVLIALGEAARRRPAAARDTAPLGSAGTLAYALLGEIGGEPASHGAPQVVAVVLGATLAGAVGRPPALDRLARRVLNAGFAATCFQPLHACGVLGRWPAHSPYYALFLLLLLALTALCDAVVAAVLTRARAGGAYGPVLREELRALPGIGSAIGATGVVMALAVAAAGLWALPVFCLPLLVTQLSLHRYEAVRATRRQTIASLARATEIAGYTPAGHARRVAALGRAVGRELGLSRAELTVVEYAALMHDVGQLSLTEPLPAGATEPLPAEQRRRIAMLGGAVVRQTGVPPEVALVVERQADPYRDQPLTARVVRTVNAYDDYAADPACGPLRALERLRLATAHDHEPRVVEALATVLARGRPAPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEY8</accession>
    <name>A0A2G1XEY8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24565</name>
        <name evidence="4" type="ORF">CYQ11_21505</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49719">
        <property type="protein sequence ID" value="PHQ49719"/>
        <property type="gene ID" value="BLA24_24565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16709">
        <property type="protein sequence ID" value="PPT16709"/>
        <property type="gene ID" value="CYQ11_21505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="170" mass="17098" checksum="0CB23C7C55BEB78B" modified="2018-01-31" version="1">MDTAGVTALGLSDEARSLHWLLTDLVEEVPGVLSVAVVSSDGLLLLSSSPERTAPAGPAGAPQPCGARGTEGPRGSTADLATIVAGLGSLTTGAAALMDGGVVKQTMVAMDGGGLFVMTISDGSLLGVHTAPDCDMSIVAYQMALFVGRAGHVLTPELRRELRQSVEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF05</accession>
    <name>A0A2G1XF05_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="5" type="ORF">BLA24_19370</name>
        <name evidence="6" type="ORF">CYQ11_11430</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49813">
        <property type="protein sequence ID" value="PHQ49813"/>
        <property type="gene ID" value="BLA24_19370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13411">
        <property type="protein sequence ID" value="PPT13411"/>
        <property type="gene ID" value="CYQ11_11430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="19178" checksum="AA720A3C411A1092" modified="2018-01-31" version="1">MAKKEKTGRKLVAQNKKARHDYHILDTYECGMVLTGTEVKSLRQGRSSLVDGFVQIDGGEAWLHNAHIPEYAQGTWTNHTARRKRKLLMHRAEIDKLDSKSQETGHTIVPLAIYFKDGRAKVEIALAKGKKEYDKRQTLREKQDTRESNRAIAAARRRQRAQQTQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB8</accession>
    <name>A0A2G1XFB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20115</name>
        <name evidence="4" type="ORF">CYQ11_10675</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49934">
        <property type="protein sequence ID" value="PHQ49934"/>
        <property type="gene ID" value="BLA24_20115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13290">
        <property type="protein sequence ID" value="PPT13290"/>
        <property type="gene ID" value="CYQ11_10675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="281"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="538" mass="57092" checksum="E3D31059B73DE92B" modified="2018-01-31" version="1">MQQAPVLGSAVDPASDAWRANEAAHRELVARLREKLAAARLGGGEKARARHTARGKLLPRDRVDALLDPGSPFLEIAPLAADGLYGGAAPAAGVIAGIGRVSGRETVVVANDATVKGGTYYPLTVKKHLRAQEIALENRLPCLYLVDSGGAFLPMQDEVFPDRDHFGRIFYNQARMSGAGIPQIAAVLGSCTAGGAYVPAMSDEAVIVRGQGTIFLGGPPLVKAATGEVVTAEELGGGEVHSKVSGVTDHLAENDEHALRIVRTIVSTLPARGELPWSVEPVEEPAADPAGLYGAVPVDSRTPYDVREVIARVVDGSRFAEFKAEFGQTLVTGFARIHGHPVGVIANNGILFSESAQKGAHFIELCDQRGIPLVFLQNISGFMVGRQYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNAKISVMGGEQAASVLATVKRDQLEARGEEWGVEDEEAFRAPVREQYETQGSAYYATARLWDDGVIDPLETRQVLGLALTACANAPLGEPGYGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN0</accession>
    <name>A0A2G1XFN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20740</name>
        <name evidence="2" type="ORF">CYQ11_10040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50038">
        <property type="protein sequence ID" value="PHQ50038"/>
        <property type="gene ID" value="BLA24_20740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13184">
        <property type="protein sequence ID" value="PPT13184"/>
        <property type="gene ID" value="CYQ11_10040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="29360" checksum="18A72DCBDC0F80CE" modified="2018-01-31" version="1">MARIDTLLGVDFDGRAVDDPYDVVDEGLDDPRHRERVPGLVALMHDSAASDHDRLTACIALLTWGEAAGHEAVVAGAADPKKAAWYDSCIDRKFSVDNTFGHIARAMASYGSSGMCEEKGTQAGRVEAVRALIRIADTEYFDEQLEWAVASCAEEPGVVDDVEDVIQRGVLRLSGDTRVIGFDLATQLVDLACAVSDADPRRAMRLAAEVLFVAPSDRALKHAEAIASRADGPDEELFAGHLRSVGAALHSFVKIRQNASAARTPTATDRTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFP1</accession>
    <name>A0A2G1XFP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20825</name>
        <name evidence="4" type="ORF">CYQ11_09955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50052">
        <property type="protein sequence ID" value="PHQ50052"/>
        <property type="gene ID" value="BLA24_20825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13169">
        <property type="protein sequence ID" value="PPT13169"/>
        <property type="gene ID" value="CYQ11_09955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="32680" checksum="DD79C402CC63A586" modified="2018-01-31" version="1">MSHQQPGPYGPPPQQPQQPPAYGPPQGTPYGPPQGAPQGAPQQYPTPGYGAPHYPSPYPPVPPQGGGKGKRTGLVVGAVVVAAALVAGGLFLLKDGKSDGGAKAGKAGAGSSPGASGSPSPSASPAAKRYKLITPDTVGEYKKDPTQSSGESTSQDDVQALTAFGLTNPKSVDAVYTAGAGAGGRPQRLMTFTGGWGDELKHPEAAVDLMFMSIKVGTGKNGGSDVRTDPQGQPQKVTPAGLEPGAVMKCQLTKMSSREKGGTASGPDNMTMPVCVWADTSTLGMVFVADIALIERGKALSLDEAASRTVTLRQGLRVENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS1</accession>
    <name>A0A2G1XFS1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="15" type="ORF">BLA24_21040</name>
        <name evidence="16" type="ORF">CYQ11_09745</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50083">
        <property type="protein sequence ID" value="PHQ50083"/>
        <property type="gene ID" value="BLA24_21040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13136">
        <property type="protein sequence ID" value="PPT13136"/>
        <property type="gene ID" value="CYQ11_09745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="64"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="293"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="797"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="721"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ50083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT13136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="949" mass="105529" checksum="4963AF08F3CA98CC" modified="2018-01-31" version="1">MSETPTAAEVAAPHRYTAALAADIEARWQDFWDADGTYEAPNPGGELAGDAEVVARPKKFVMDMFPYPSGAGLHVGHPLGYIATDVYARYHRMTGHNVLHTLGFDAFGLPAEQYAVQTGTHPRVSTEANIVNMKAQLRRLGLGHDKRRSFATIEPEYYKWTQWIFLQVFNSWYDEEAKKARPISELVEQFESGRREVPGTRAWSELSAAERADVLGDHRLAYASDAPVNWCPGLGTVLANEEVTADGRSERGNYPVFKSKLRQWNMRITAYADRLLEDLDALDWPEAIKLQQRNWIGRSEGARVDFAVSDGSEAKVTVFTTRPDTIFGATYMVLAPEHDLIDSIVPAEWPEGTKEVWTGGAGTPGEAVAAYRKQAQAKTDVERQTEGKDKTGVFTGAYALNPLTGEKIPVFVGDYVLMGYGTGAIMAVPGQDERDWEFATAFELPIVRTVQPPEGWEGEAFTGQGPAINSANDEIDLNGMGVDEAKRTVIAHLTERGIGEGTVNFRLRDWLFSRQRYWGEPFPIVYDEDGVAHALPESMLPLELPEVDDYTPRTFDPDDADTSPETPLSRNEDWVDVELDLGDGPKRYRRETNTMPNWAGSCWYELRYLDPRNDEQLVSADAERYWMGPREGKPHGGVDLYVGGAEHAVLHLLYARFWSKVLFDLGHISSCEPFHKLYNQGMIQAYVYRDARGMAVPAAEVEERDGAYYYEGQKVSRLLGKMGKSLKNAVTPDEICSEYGADTLRLYEMAMGPLDVSRPWDTRAVVGQYRLLQRLWRNVVDEATGEVTVVDAEPDEATLRALHKAVDGVSQDMANLRFNTAIAKVTELNNFVTKLREVPRSVAEQLVLLIAPLAPHIAEELWRKLGHTDSVVHRDFPVADPAYLVDETVTCVVQIKGKVKARLEVAPSISEDELEKVALGDPAVVAALGGAGVRKVIVRAPKLVNIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFZ4</accession>
    <name>A0A2G1XFZ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21505</name>
        <name evidence="3" type="ORF">CYQ11_09280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50158">
        <property type="protein sequence ID" value="PHQ50158"/>
        <property type="gene ID" value="BLA24_21505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13058">
        <property type="protein sequence ID" value="PPT13058"/>
        <property type="gene ID" value="CYQ11_09280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="95" mass="10230" checksum="8666C1BC814AEDB2" modified="2018-01-31" version="1">MRYRLTFITGVAVGYVLGARAGRERYEELRKGARRIAQNPVVRNTAESAAVNGRALAAKAAGKAGDRLPGSVAGRVRSLREQRGADEDEWGTSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG05</accession>
    <name>A0A2G1XG05_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">BLA24_20945</name>
        <name evidence="8" type="ORF">CYQ11_09835</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008738950.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50069">
        <property type="protein sequence ID" value="PHQ50069"/>
        <property type="gene ID" value="BLA24_20945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13150">
        <property type="protein sequence ID" value="PPT13150"/>
        <property type="gene ID" value="CYQ11_09835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="84" mass="8747" checksum="CF21D8F66567E437" modified="2018-01-31" version="1">MAHKKGASSTRNGRDSNAQRLGVKRFGGQVVSAGEILVRQRGTHFHPGAGVGRGGDDTLFALQAGAVQFGTHRGRKVVNIVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG45</accession>
    <name>A0A2G1XG45_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="6" type="ORF">BLA24_21610</name>
        <name evidence="7" type="ORF">CYQ11_09175</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50175">
        <property type="protein sequence ID" value="PHQ50175"/>
        <property type="gene ID" value="BLA24_21610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13042">
        <property type="protein sequence ID" value="PPT13042"/>
        <property type="gene ID" value="CYQ11_09175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="82" mass="9026" checksum="E56BDC7BE4E8268A" modified="2018-01-31" version="1">MAHTQEQIVEGLAEIVNEIAGIPTEDVKLDKSFTDDLDVDSLSMVEVVVAAEERFDVKIPDEDVKNLKTVGDAADYILKHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGD6</accession>
    <name>A0A2G1XGD6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22395</name>
        <name evidence="4" type="ORF">CYQ11_08390</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50303">
        <property type="protein sequence ID" value="PHQ50303"/>
        <property type="gene ID" value="BLA24_22395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12910">
        <property type="protein sequence ID" value="PPT12910"/>
        <property type="gene ID" value="CYQ11_08390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="645" mass="67263" checksum="2379D18DD9468554" modified="2018-01-31" version="1">MEQQATAPRPFAPAPVDVEQAEAALIEHYPRLVRLGYLVLPPALGRNRRVLTAHALVQRALPRHRAEVREPAVPQPRGAETSPGDPGYAYVRRRVLQAALEAGRPRGRWGLPRPGQLPPLLPQVWGLRLFPRSGGADELALDQALATLSGPARAAYVLRALELPTDHDVRLLLAAAGVEDPDAALTEADRARTPAGSRDASLLESVEFDPCSLQARPTDLMRRRQHTRAALAALAAVVVCGTLLGLPGDGWGRDGAAAPPYAQNPAAQQALDPARLTRVPATAWKRADHPGFASWPARGNRTGDRALLRRALAVWARPGHTVQVTATPGTATGPAAGPPQLLYAGEVDAAAVVLFHDGLRVVRYAEAKNGATGSAALDFARADAAEAASATALVLGRTDGNVRYLTAPWLTSAGVRNLLEPTAPVKPLHRDADGVTDAVPSPGATNDCHDWTALQLGAHLVTDLAELVPARLTAGAPTAPHDVGGPAERADWAHTACHLATIRGQGVRAVNNWQFATQPLPGGAGSAAWSCTRAETWRGAGSRVLAQFLPPGTRAAAPASVVARAEDSPACGTPEPHVLAGVLWKSQGGTWYALAAGDGDVTSVAATGGVRGSAAGHLLAVPARQGAQAELTARLPDGGKLSQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGM9</accession>
    <name>A0A2G1XGM9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20245</name>
        <name evidence="4" type="ORF">CYQ11_10540</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50377">
        <property type="protein sequence ID" value="PHQ50377"/>
        <property type="gene ID" value="BLA24_20245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16475">
        <property type="protein sequence ID" value="PPT16475"/>
        <property type="gene ID" value="CYQ11_10540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="34457" checksum="47CDF8E8317E0D37" modified="2018-01-31" version="1">MRVGLLGAGRIGAFHAATLTRTDGVGELVIADADPARATDLAAATGARAAGSVSEVFHAAGVDAVVIATATAAHAALVTRAARAGLPAFCEKPVALDLAGTVRALREVEAAGTLLQIGFQRRFDAGYRAARAALRSGALGRVHTIRCVTSDAAPPPAAFLPQSGGLIRDCMVHDFDAVRWMTGREVVEVYARGTDAGAAFFREAGDVDTAAALLTLDDGTLVTATATRYNGAGYDVRTELSGERDQWVVGLTGRTPATSADPAGPGAPVRPWSGFLERFEDAYRAELAAFVRAARGEAGNPCPGAEGLRALHIAEACEVSRREGRPVRLAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGP2</accession>
    <name>A0A2G1XGP2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21110</name>
        <name evidence="3" type="ORF">CYQ11_09675</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50397">
        <property type="protein sequence ID" value="PHQ50397"/>
        <property type="gene ID" value="BLA24_21110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16456">
        <property type="protein sequence ID" value="PPT16456"/>
        <property type="gene ID" value="CYQ11_09675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="244" mass="25458" checksum="E6E110C13C4B13EE" modified="2018-01-31" version="1">MQGDSGGAEARWERLAPGVVRRRLPGWDATVGAIAGEGGVLVVDTGSSLHEGVEIRREVQELFGPPVTHIALTHPHFDHVLGTAAFAGVQVYGAVGAADLLRRDRDELRHDAVRHGVAPDVAAEAVELLVLPHHPVSGELTVDLGGEVRVLLANVGPGHTAHDLAVLVAVPGGPEVVFCGDVVEESGEPQAGPDALPHAWPAALDRLLALGGDDAVYVPGHGAVVDAEFVRRQRDALAERFGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH45</accession>
    <name>A0A2G1XH45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16570</name>
        <name evidence="3" type="ORF">CYQ11_16715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50459">
        <property type="protein sequence ID" value="PHQ50459"/>
        <property type="gene ID" value="BLA24_16570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14286">
        <property type="protein sequence ID" value="PPT14286"/>
        <property type="gene ID" value="CYQ11_16715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="369" mass="40317" checksum="9539A1EE721CF8FD" modified="2018-01-31" version="1">MGLTSMAVLLLAIAAAVALFALTIWLWPRLGKKNVGSVLARVGMMLATQVSLFAAIGLWANQSFGFYGSWADLFGQVKDEGVVVDHSASGKRVQVVKTQAVKVPRGNVPRVGGKIEKINIAGPESKINSPAYVYLPPEYFQPEYANRKFPASVALTGYPGTAEALVKGLDYPVRAHKLAKQKKMQPTILVMMRPTVAPPRDTECIDIPNGPQTETFFVKDLRKAISQQYRVGDKAANWGIIGDSTGGYCALKFAMRHPEAYGAAASLSGYYKAPQDATTGNLFGGSKQLENENDLLWRLKNKDMPPVSLLVTSSKKGEHNYKDTLKFIESVKAPARVSSIILDTGGHNFNTWRRELNPTLQWMGSRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHJ4</accession>
    <name>A0A2G1XHJ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ORF">BLA24_17915</name>
        <name evidence="7" type="ORF">CYQ11_15360</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50671">
        <property type="protein sequence ID" value="PHQ50671"/>
        <property type="gene ID" value="BLA24_17915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14074">
        <property type="protein sequence ID" value="PPT14074"/>
        <property type="gene ID" value="CYQ11_15360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="11738" checksum="8046F579A3454F90" modified="2018-01-31" version="1">MALKAVTDASFDEEVLKSDKPVLVDFWAEWCGPCRQIAPSLEAIAAEHGEKIEIVKLNIDQNPTTAAKYGVMSIPTLNVYKGGEVVQTIVGAKPKAALERELSNFIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK7</accession>
    <name>A0A2G1XHK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenylacetic acid degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_18170</name>
        <name evidence="8" type="ORF">CYQ11_15105</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50712">
        <property type="protein sequence ID" value="PHQ50712"/>
        <property type="gene ID" value="BLA24_18170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14035">
        <property type="protein sequence ID" value="PPT14035"/>
        <property type="gene ID" value="CYQ11_15105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="272"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="361" mass="38862" checksum="87D1A7EC83CC3C12" modified="2018-01-31" version="1">MAAARHGAFHPLRVTAVDPLTDDSVALTLAVPPELRDAFRHLPGQHLALRRTLDGAEIRRTYSICGPAAGPGGPGTLRVGVRLVDGGAFSTYALKELAAGDTVEVMAPAGRFVLEPRPGHFAAIVGGSGITPVLSMVTTLLAREPRARFCLIRSDRTTASTMFLDEVADLKDRYPDRFQLVQTLSREEQEAGPASGRLDEGRLTALLPSLLPVESVDGWFLCGPHGLVRSAKRALDHLGVARDRIHEEIFHAEEIPAGGPQSPTAAPAPEHSTLTARLDGRSGSWSVRDGEPLLETVLRNRADAPYACKGGVCGTCRAFLVTGEVRMDRNFALEQEELDAGYVLACQSHPVTEKVELDFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHN0</accession>
    <name>A0A2G1XHN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18315</name>
        <name evidence="3" type="ORF">CYQ11_14960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50736">
        <property type="protein sequence ID" value="PHQ50736"/>
        <property type="gene ID" value="BLA24_18315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14006">
        <property type="protein sequence ID" value="PPT14006"/>
        <property type="gene ID" value="CYQ11_14960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="35324" checksum="DA408E917183D734" modified="2018-01-31" version="1">MRAAYGPSTRVRVWNGPCCAIYLRLTDTCSVGIGGRVDRVDRLDGESISRLLRAWRARVDAKNLPELRGVFPRPGRRLSQAHVARMTGVSEGWYRALEAGRRQDFSESFLLRVAGALRLSDAETLTLFLAVCGRRPPEPGREQRDLPQGVKALLEQQVTYPAYLSDTAWNVIAANPLMGEWFPWVLRPKPNLMRWALLHPEAREQMLDWEDSCARVYLAMLRVATNSDPANDELRALLQEILEADADCRRIWAEEHDVVEHRDGHVFRLRLPYHGNVETRVTSHVLLPIQRQDLRFVFITPMDGWAGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHY5</accession>
    <name>A0A2G1XHY5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50739">
        <property type="protein sequence ID" value="PHQ50739"/>
        <property type="gene ID" value="BLA24_18330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="130" mass="14303" checksum="8288AD145CBAB048" modified="2018-01-31" version="1">MNHVREETLKNWREKGEGTGSIPFKLADKGFWGSKWRLVSEDLPAIVTGDEAKLGEAFMGSYNLDYEVKGTDSDGSVIVQYSISNTTSKASLMHYVGYGDWLEAFNSDSGPGGNVSQNVVWTEKIPPHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI05</accession>
    <name>A0A2G1XI05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17330</name>
        <name evidence="8" type="ORF">CYQ11_15945</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50878">
        <property type="protein sequence ID" value="PHQ50878"/>
        <property type="gene ID" value="BLA24_17330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16594">
        <property type="protein sequence ID" value="PPT16594"/>
        <property type="gene ID" value="CYQ11_15945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="501" mass="50957" checksum="42A1D303EA31833F" modified="2018-01-31" version="1">MTATTAASPHRSSEEKPHRNPTRWVVLGVICLAQLTVLLDNTVLTVAIPSLTEEMGAATADIQWMINAYSLVQAGLLLTAGSAADRYGRKKMLAAGLVLFGLGSLAAAMSQTTGQLIAARAGMGVGGALLMTTTLAVVVQVFDDDERPKAIGLWGAVGSLGFAAGPLIGGALLNHFWWGSIFLINLPVALFGLLAVLKWVPESKSPSGDRPDLLGALLSTVGMTGVVFAIISGPVHGWTSGRVLGSGVGGVAVLALFALWERRCPYPMLDMHFFRNSRFTGAVAGGILVAFGMGGSFFLLTQHLQLVLHYDPLETGLRMTPLALVIVVLNLTGVGARLLPKVGTPVAIAGGMGLLAAGLASIAVLGAHAYGGMLLGLILMGVGISLSMPAMANAIMSAIPPEKAGVGAGVNGTLQECGNGLGVAVLGAVLNSRFAALLPAVAAGAGSLPAALSKADTAAERSEIQDAFASGVQASQLVGAGAVLAGGLLAGALLWRAERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIB7</accession>
    <name>A0A2G1XIB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14475</name>
        <name evidence="4" type="ORF">CYQ11_13600</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50994">
        <property type="protein sequence ID" value="PHQ50994"/>
        <property type="gene ID" value="BLA24_14475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13784">
        <property type="protein sequence ID" value="PPT13784"/>
        <property type="gene ID" value="CYQ11_13600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="2">
        <location>
            <begin position="56"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="435" mass="45469" checksum="7DD3BD5ADA844C6B" modified="2018-01-31" version="1">MSEPTEPTPEQPAEVTPEPTPEPAPEVPVGWLPRGVVELFGEGATAEEAYDLLTVDVPAQAWLSALETARDVVGCTFFDWLSAVDEPGTGFRVSAHVAALPGPGGRQGVRRLLVRTTVPHEAPALPTAVDVYAGAAWHERETHEMFGIDFPGHPHLVPLLLPDSFEGHPLRKDFVLAARVVKAWPGAKEPGEPAEGGPKRRQMLPPGVPDPNEWGPLKGQLPPAPARPARTPRAAGDRPVRRARSVSEGSASQAEGAAPAPRRARSAAEGSASQVPSEAPAPRRTRSVSEGSASQAEGAAPAPRRARSASEGSASQQPATDETGPTRPRPAPRSSDAPWHHARPAFDEKPEAEAAPEPKAKPATGAEPGTEPKPEPKPEPATGTEPGTEPKPEPKPEPATGTEPGAADRAADRPADRPGDEPDHDDTNPAGGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XID1</accession>
    <name>A0A2G1XID1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14570</name>
        <name evidence="3" type="ORF">CYQ11_13505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51008">
        <property type="protein sequence ID" value="PHQ51008"/>
        <property type="gene ID" value="BLA24_14570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13770">
        <property type="protein sequence ID" value="PPT13770"/>
        <property type="gene ID" value="CYQ11_13505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="415" mass="42232" checksum="7647168065DFF987" modified="2018-01-31" version="1">MPDSQPQPARNPDAAPPPGDGTLVLCGARLADGRVVDVRLSGGRIEAVGTAGSLAPGPRVDLAGYLLLPAPAEPHAHYDTALTADLGGPVPYGVEDVQRRATEAALLQLGHGVTAVRTHVRVGDVQGLRSLEAVLQARRALRGLTELSAVAVPRLLTGVAGADGLAVLRDAVKMGATVIGGCPDLDPDPTGYAEVVLSLAAEHGCAVDLHTDADDPARLARLAAMAGGLRPGVVLGPCGGLSRLPRDQAVRAGQQLAAAGVTLVCLPQGDCCASRGAWRAPVRLLRATGVRVAAGSGALRDAAGPVGRGDPLEAAFLLAARGELGPEDAYEAVSGRARAATGLPEVRVEAGFPAELLAVRGDGVAGVLSLGYSRLVVHRGRVVARTSAVREYGDVQATVALDLPRQSPRGGDPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIL2</accession>
    <name>A0A2G1XIL2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ORF">BLA24_14890</name>
        <name evidence="10" type="ORF">CYQ11_13180</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51063">
        <property type="protein sequence ID" value="PHQ51063"/>
        <property type="gene ID" value="BLA24_14890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13714">
        <property type="protein sequence ID" value="PPT13714"/>
        <property type="gene ID" value="CYQ11_13180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="18383" checksum="52E57B70101E2039" modified="2018-01-31" version="1">MAETTAETPLEGVEEYTTETEVVESEYTSESLASRFGDPQPAAGLGRRKNAIARVRIVPGSGKWKINGRTLEDYFPNKVHQQEVNEPFKVLELDDRYDVIARIAGGGVSGQAGALRLGVARALNEADVDNNRGPLKKAGFLKRDDRAVERKKAGLKKARKAPQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIQ9</accession>
    <name>A0A2G1XIQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51134">
        <property type="protein sequence ID" value="PHQ51134"/>
        <property type="gene ID" value="BLA24_15290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="111" mass="12160" checksum="9F9DC14421595748" modified="2018-01-31" version="1">MTVLGALSSWYVQVIDRDWVDREQAACGPLPFPRTEYVAAWGGLALGVAAVVACVLLAQRIRRRCGVGLWSTRSGLLAYVSVWFNGLAIPFELLMLYCVYVPDPSGAPHCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ06</accession>
    <name>A0A2G1XJ06_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_15885</name>
        <name evidence="5" type="ORF">CYQ11_12190</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51234">
        <property type="protein sequence ID" value="PHQ51234"/>
        <property type="gene ID" value="BLA24_15885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13542">
        <property type="protein sequence ID" value="PPT13542"/>
        <property type="gene ID" value="CYQ11_12190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="25351" checksum="0B1686A490507952" modified="2018-01-31" version="1">MIDAVAIDSSSTGKKDPSAPTGARRTRPRRVRMTGAERREQLLDIGRALFAERGFEGTSVEEIAAKAGVSKPVVYEHFGGKEGLYAVVVDREMRQLLDMVTGALTAGHPRELLEQAAFALLDYIESYTDGFRILVRDSPVAQSTGTFASLISDIATQVEDILGLEFKARGFDPKLAPLYAQALVGMVALTGQWWLDVRKPKKAEVAAHLVNLAWHGLDGLEPKPRLVGHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ46</accession>
    <name>A0A2G1XJ46_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15460</name>
        <name evidence="4" type="ORF">CYQ11_12615</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51159">
        <property type="protein sequence ID" value="PHQ51159"/>
        <property type="gene ID" value="BLA24_15460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13618">
        <property type="protein sequence ID" value="PPT13618"/>
        <property type="gene ID" value="CYQ11_12615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304680" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="47"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="185" mass="20303" checksum="C3106D30BC296E3A" modified="2018-01-31" version="1">MKSHFRLPGILAAAAALLLTSGVTSASATTPQDGAKQDRRAQNGADSYGWIRNANSAHCLAVPGASTQNGVGLIQWGCGGWRDHYWQFEYAFSSGGMSYYHIRNLNSQQCLAVPGASTTAGTQVIQWPCDKWADHYWGIEYTDKGKRLVNWNSKQCLAVPGASTTQGEKVIQWPCGTWADHYWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJA0</accession>
    <name>A0A2G1XJA0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_16170</name>
        <name evidence="5" type="ORF">CYQ11_11905</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51280">
        <property type="protein sequence ID" value="PHQ51280"/>
        <property type="gene ID" value="BLA24_16170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13495">
        <property type="protein sequence ID" value="PPT13495"/>
        <property type="gene ID" value="CYQ11_11905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="12792" checksum="C24F9717F13E4643" modified="2018-01-31" version="1">MDREMVGNASRGRLQVEVRRHGVSSVVSPTGELDHHTAELLREPLEGCVREGDARVVVDCSGLDFCDSTGLNVLLGARLKAEAAGGAIHLAAMTPVVARVFEITGAGAVFTVHDTLDSALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL7</accession>
    <name>A0A2G1XJL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13915</name>
        <name evidence="4" type="ORF">CYQ11_01610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51423">
        <property type="protein sequence ID" value="PHQ51423"/>
        <property type="gene ID" value="BLA24_13915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11764">
        <property type="protein sequence ID" value="PPT11764"/>
        <property type="gene ID" value="CYQ11_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="408" mass="45626" checksum="6AF21EE822C96435" modified="2018-01-31" version="1">MLSSESVAATFLSHGSADLHPVMKSLRDEAPVFFSEDLHMWIVSRYDDVTEILKNAELFPASTRSIIMSSYPPEVREVLASTSTFTAPNMGFDGSPAHERLRKPVVPYFSAKGARLLEPRIEEIAGLRAEEVPAEPPVDLVQAYARPLANSVVIALAGFPAEDHDRILRYHRAVNEFFFGRPPAHLQLDYAHDLLEWEQYLSALLAARRRDPRDDLISLLTRKVARGEADYTEQELISFLSFDVVTAGFRPTSFALVTLFDELLEDPRRWQSLREDPGCFDGLFSEALRRSGPALGVFRMTAADTEVGGVPVPAGSVLWVMTASANRDERRFPEPDAFDPHRPRMAGSLHFSQGLHYCLGANLARIVARAGVSALMRRHPRLRLVPGQERVYEPSINVVAPARLLVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJN9</accession>
    <name>A0A2G1XJN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13205</name>
        <name evidence="3" type="ORF">CYQ11_00925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51468">
        <property type="protein sequence ID" value="PHQ51468"/>
        <property type="gene ID" value="BLA24_13205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11650">
        <property type="protein sequence ID" value="PPT11650"/>
        <property type="gene ID" value="CYQ11_00925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="245" mass="27704" checksum="D8DE13C4D7D5F71F" modified="2018-01-31" version="1">MLTIGQLAATAGVTVRTVRHYHHVGLLPEPERDASGYRRYGAQAAVDLIRIRTLADAGVPLARIDALLHARPTEFAAAITDIDAELQRKIDQLTGYRRRITELASGERLVLPLEVVAILNRMRSLGVSEQRVRLERDSWILIQALDPHAMPQRIRDKNASLDDPETTRLYLACDQSVDWDPHDPRLDRLIDDLDAWEIKHERDSGQPRYLKLVSSRISEASPAWQRILDALAHRATQRRTAGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJS5</accession>
    <name>A0A2G1XJS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13695</name>
        <name evidence="4" type="ORF">CYQ11_01390</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51389">
        <property type="protein sequence ID" value="PHQ51389"/>
        <property type="gene ID" value="BLA24_13695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11729">
        <property type="protein sequence ID" value="PPT11729"/>
        <property type="gene ID" value="CYQ11_01390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="33393" checksum="AE11BC84F202CDFD" modified="2018-01-31" version="1">MDLNAVRTFVAAADAGQFQQAATDLSITQQAVSKRVAGLEKDLGVRLFTRTASGVRLTIDGQALLPHARDLLRVAERAAASVRPGRRALRVDVIGRRLATAALLRDFHRARPELELDVVTLFDADAAVAAVRSGTIDASFRAVTMPGRSLPDGIETARVLDEPLQLLTGPGHAFAAARAVTPAELAGHRIWMPGVVPGTEWAAYYDDLAAAFGLTIDAIGPDFGVEPLLDAIADSPELATFLGAHSRIVWPVDYDLRRVTVHRPTPVYPHSLIWHRDNPHPALAALRDHLAAGQPDHAGAETWTPAWAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJW0</accession>
    <name>A0A2G1XJW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13490</name>
        <name evidence="3" type="ORF">CYQ11_01210</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51516">
        <property type="protein sequence ID" value="PHQ51516"/>
        <property type="gene ID" value="BLA24_13490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11698">
        <property type="protein sequence ID" value="PPT11698"/>
        <property type="gene ID" value="CYQ11_01210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="26037" checksum="EE187E1BA6372477" modified="2018-01-31" version="1">MSYPALAARTAVVTGAASGIGAATARQLAAGGARVALLARRADRLDALAADINAAGGQALAVTADVTDQASVDAAAKAVHDAYGRVDLVVNNAGVMLANPLADGRLDEWTRMIDTNLTGVLRVVHAFTPDLTAAAADGRTADLVNVSSIASHVLFPDYAVYGATKAAVTQLSAALRTELGPRDVRVSAVEPGLTDTELGGHIDNPALREQLGGMFTAIPALTSEDVADLIAYTVSRPRHVNLRQSVVLPTRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK04</accession>
    <name>A0A2G1XK04_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12805</name>
        <name evidence="4" type="ORF">CYQ11_17160</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51575">
        <property type="protein sequence ID" value="PHQ51575"/>
        <property type="gene ID" value="BLA24_12805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14367">
        <property type="protein sequence ID" value="PPT14367"/>
        <property type="gene ID" value="CYQ11_17160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758522" evidence="2">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="139" mass="13083" checksum="8ECE37C58795BCE6" modified="2018-01-31" version="1">MRRVLTAAALATAALTLGTAPAAQAADLPKALDLGGLTAVDPGSLGDTVDGAARKATGLAGGAGSRAVKKAVPTAGKVSGKAVKSTTSAAQKAAGDVAGSAVDVLGETAGTATESGLPTDTLDGGLPARGLPLTGRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK92</accession>
    <name>A0A2G1XK92_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DoxX family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_12560</name>
        <name evidence="8" type="ORF">CYQ11_17475</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51655">
        <property type="protein sequence ID" value="PHQ51655"/>
        <property type="gene ID" value="BLA24_12560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14420">
        <property type="protein sequence ID" value="PPT14420"/>
        <property type="gene ID" value="CYQ11_17475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="542" mass="55215" checksum="471A557818EBBB46" modified="2018-01-31" version="1">MSVDTRTPRTPTGGSSSGYDDQPALSTVKVPSDPAQVIVNHLSFRVQLARPPRAARHLAGADTAQLPTAKGTARRRAPVVWSGRTGPGDEASTQLLQAVRESGAAGPVRTAGGGDAGATQVLPRISVDDAPTTVIGPREPADPTGRRTTGTPLLQGVRPTHGAYDDEHGDYGDYAGYDEFDEQGLDEDDGPRRDRDSVRHAYYPGRRMNLGVVLLPLRVFLGLISIYAGMGKLCDPVYFDGGKRGSMVHWLTGLHPWGVASPLRDFALSHPVGAGLTVAFLQVVAGILTIFGLWQRLAAAIGVLLSTILIVTVSWRSTPVYDSADIIYLAAWSPLVIAGAPFYSIDGRLASEAWRRLGPRAEVRQLRRRVLRRGTVMATVLIGISLLTGSMLGGAVRSSRVAEAPGTPAPPANSLPGSPLPQRPSSSAPRGSHGPATAGTPKPSATTHRAPTPGATPSAPGTPHTPAGTAGSAGQPATGPGSVRPAPQTPHQAPAPAAPPRSSSGSSTGGSTGGGAGGGSGGSSGGGSGGSRGGGALGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK96</accession>
    <name>A0A2G1XK96_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_12520</name>
        <name evidence="8" type="ORF">CYQ11_17515</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51663">
        <property type="protein sequence ID" value="PHQ51663"/>
        <property type="gene ID" value="BLA24_12520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14426">
        <property type="protein sequence ID" value="PPT14426"/>
        <property type="gene ID" value="CYQ11_17515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="524" mass="54528" checksum="EEEF5CA902C94064" modified="2018-01-31" version="1">MSSTSQPPAPASVPASGADPRRWWGLVVIALAQLMVVLDATVVNIALPSAQRALGMSDANRQWVVTAYTLAFGGLLLLGGRIADLVGRKRTFVIGLVGFAVASGLGGAARTDWQLFGARALQGVFAALLAPSALSLLTTTFTDPKERGKAFGVYSGIAGAGSAIGLLAGGLLTEYLNWRWCLYVNVPIALVAVLGALWMLHDHRPAHRPRLDIPSVLLACTGLVSIVYACSEAEPRGWGDPLVTGLLCAGAVLLTVFGWWQHKAPSPLLPPRITRDRNRAGAFLALALSVIAMFGMFLYMTYYFQGVLGYRPVTAGLAFLPLSATIILTTTQLSSRLLNHVPPRMMITPGAVCSAIGLFLLTSLPVEGAFATHVLPSEILFGIGMGLTFVAVMDTATRGVAPGDSGVTSATVNTSQQVGGSVGTALLNTIATSTAGAYVAAHLTAAAATGPLTPAVRDAITKSGVVHGFHVGLAWGSGVMLLAALVSWVLITAPAPEHRGPEDGEALTEGQVAPVYDAHRMRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKG4</accession>
    <name>A0A2G1XKG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11570</name>
        <name evidence="3" type="ORF">CYQ11_02805</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51722">
        <property type="protein sequence ID" value="PHQ51722"/>
        <property type="gene ID" value="BLA24_11570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11970">
        <property type="protein sequence ID" value="PPT11970"/>
        <property type="gene ID" value="CYQ11_02805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="199" mass="20786" checksum="AA9DDE421F48B8DF" modified="2018-01-31" version="1">MTASATSSGATGFSPTHVVPGGGLATWAVPDASVPSDPLDPLLPVRLLNRHGDWGQVLCSNGWSAWVDARLLVALPQRPPAAGGPLVRTADARKLLARVETAIERYRQAVEELAAGRMDGETFRATTRGLRIGAVVEGEAVWLYDAQRDHWCYCDGTAMTVFAPSSGPQSAPGPVPRSSAAEETRLDSPPSGPPPAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL1</accession>
    <name>A0A2G1XKL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_11830</name>
        <name evidence="8" type="ORF">CYQ11_03070</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51767">
        <property type="protein sequence ID" value="PHQ51767"/>
        <property type="gene ID" value="BLA24_11830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12014">
        <property type="protein sequence ID" value="PPT12014"/>
        <property type="gene ID" value="CYQ11_03070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="39237" checksum="153547273D38FD94" modified="2018-01-31" version="1">MSHRSAVLVLALGAFAVGTDGYVTTGILQSIADDFHVSVSVAGQLVTVFALSYAVSAPVLMTLTANVSRRVMLYGSLGLFLLANLLGALAPDYPTLLAARVLAGAAAAVYMNTAVAAATAMTDERHRGRAVSLVVGGLSLATALGVPIGTLVGALGSWRATLGVIAGLAGVGIAGLAATLPATPSPPPITMGARLRVAAEPAVLLVVLANTCAVAGSFTVYTYLAVFARDVTGLSAAGVSAVLFAWGVAAAAGTALGGRMSDRRGPDRAYLTGVLGVIAAFAALALAALVTRVAEGPATVVFLAATVAWGVLYWIVPGAQIQRVMDRAPAAPTIAVSVSSASSYLGVALGGGIGGATLSLTSSWALPLAGAALLAVAAALTARQAAGSAVPSGSPGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKN9</accession>
    <name>A0A2G1XKN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11940</name>
        <name evidence="3" type="ORF">CYQ11_03180</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51786">
        <property type="protein sequence ID" value="PHQ51786"/>
        <property type="gene ID" value="BLA24_11940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12032">
        <property type="protein sequence ID" value="PPT12032"/>
        <property type="gene ID" value="CYQ11_03180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="412" mass="41075" checksum="FBE182675C979F40" modified="2018-01-31" version="1">MLAAAALLGGAGVAGCGNDTERKAARISLEAAGVIAPKPFMEAPDSDLRGVKAVTGARSRGAFGGTPGRTRCDKATLIQQITADKVKADAWAKARGIPADKIAEHIRSLTEEIVPEDTLVKNHNYEGDGKTVAYLSVLQVGTAVLLDPYDNPAVKCNCGNPLRQPENGIDREASTYTGKRWESFQSTQVTVIIVRSPEEGPRETLPVIDVQHPDRGFNRPAGSDGSTDSKPYPVTPPPSTVPTPSGSAPGTGSPSGPGEPSGSGSPSTSGTPSGSGGPSVPGPSSGRPSTGGPVTSKPPSGKPPATSAGPPRTGSPASSRPPATGKPPVASHSAAAVQPTAARTTAAAPPVHTTAAAPPAHTTGAAPPARTTAAAPPLRTTAAPVPSRTVAPPDAVTPGGQAPPGPARSAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL01</accession>
    <name>A0A2G1XL01_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Neutral metalloproteinase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_11585</name>
        <name evidence="16" type="ORF">CYQ11_02820</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51851">
        <property type="protein sequence ID" value="PHQ51851"/>
        <property type="gene ID" value="BLA24_11585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16315">
        <property type="protein sequence ID" value="PPT16315"/>
        <property type="gene ID" value="CYQ11_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-0969">Cilium</keyword>
    <keyword evidence="15" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="13">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="11">
        <location>
            <begin position="224"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="12">
        <location>
            <begin position="394"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ51851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT16315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="572" mass="58948" checksum="EF7C2BB21C288291" modified="2018-01-31" version="1">MVGTAAAAPSPAARTTASSPAGADVVKAARAAALAHAKDTGVGSSDTLKVRDTLVDPEGKRHVRFERSHQGVAVIGGDLVVHLDAENTYLGVTRAIGHQVTVPTVTPKLTAGQAADKAAESAKGTANKTQLVVDARTGDGVLAYQVTVTGGAGTETGAAHSVVVDATSGKVISSTPLSDAFISPKLKSTLRGLGQTAAPGTAAKPGTPAPAKPATGAFPAPANGTGASIFAGGVPLITTQTAKSTFVLKDPSRGNGETRNAGRQELETFASGKQFTDADNKWGNGTSKDAASAAVDAQYGITSTFDYYKKTFGRNGIANDGVGPHALVHFGNNVGNAFWSPDCACMLYGDGDGETFKQPLVALDVTGHELSHGVIEATANFQPTRVDGQGNQYGEAGSLNESLADIFGTGVEFGTNNAVNPPNYLLGEKLGLEQKFLRRLDKPSLDKLEGTVDYWDEGSYDREVHAGSGVSSHAFYLLAEGSGRKTVGGVTYDSPTHDGQSVTGIGRAKAEQIFYRALTRYMVSTTDFHEARTATLQAAADVYGAGSTEYKTVDAAWAAVNVTQANTPAPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL68</accession>
    <name>A0A2G1XL68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_10495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000122">
        <property type="protein sequence ID" value="PHQ51972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51972">
        <property type="protein sequence ID" value="PHQ51972"/>
        <property type="gene ID" value="BLA24_10495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="69" mass="6650" checksum="A8A72ABCD4EE1907" modified="2018-01-31" version="1" fragment="single">IMRMDTVHLAAGASLGPHGIVLPGTTVGEHAAIDPASLVMRGESVPAGTHWAGNPIAGAAPVGAGQCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLB1</accession>
    <name>A0A2G1XLB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_10055</name>
        <name evidence="9" type="ORF">CYQ11_02525</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000105">
        <property type="protein sequence ID" value="PHQ52025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52025">
        <property type="protein sequence ID" value="PHQ52025"/>
        <property type="gene ID" value="BLA24_10055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11923">
        <property type="protein sequence ID" value="PPT11923"/>
        <property type="gene ID" value="CYQ11_02525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="47"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="46275" checksum="8967A7B7571ABA9F" modified="2018-01-31" version="1">MRPSSVAPATPDSAAAPAARPVRGLLGRRKNAAAEDRSPWRCLRSRSMRWWSAANLVSNLGTWMQLTVQNLLVLQLTGSAATTGLSLSVQAAPGLLFGLLGGAVVDRWPRKVTAAVSQALLAAVAFATALLVAFGALNVPVLMVLAGITGLIATVDGPATALLGNDLVPEKDVPSAIALGSVVHSAGRLAGTALAAVGIATVGTAGAYAVNGVSFLFVTAVIPFLRLQPHAREEALAAAARPRGAAAEDGRGGLAFFLSRRSLVALAVIAAVSAVLGRNYQLTLATLVTGPLHGGAGAYGLVSALLAVGGIAGAVVAGRLRRPTVRLVALLAAAGALLQIVAGLSPVLLMLLVMVVPMAIVESVSDTATTTVLQTDPPAHMRGRVLGVWRSVSTAWGLAGPPLLGLLVQGAGERGALVLGGALIVGVIGAGALAHRRRRTAARRPAPVLAPEAAFQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLV0</accession>
    <name>A0A2G1XLV0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08610</name>
        <name evidence="3" type="ORF">CYQ11_03865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52218">
        <property type="protein sequence ID" value="PHQ52218"/>
        <property type="gene ID" value="BLA24_08610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12151">
        <property type="protein sequence ID" value="PPT12151"/>
        <property type="gene ID" value="CYQ11_03865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="207"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="461" mass="48318" checksum="397411292EAD0CE3" modified="2018-01-31" version="1">MDTSSTTQPDPAALATTVASLQPRALAELAELVAFKSVADEAQFPRSECEAAADWVAGALRAEGFEDVALLDTPDGTQSVYGHLAGPAGAPTVLLYAHYDVQPPLNEDAWISPPFELTERDGRWYGRGAADCKGGFIMHLTALRALKEHGGVPVGVKVIVEGSEEQGTGGLERYAEAHPELLAADAIVIGDAGNFRVGLPTVTATLRGMTMVRVQVDTLEGNLHSGQFGGAAPDALAALIRVLDSLRAEDGSTTVDGLTAAQEWEGLQYGEDAFRQDAKVLDGVSLIGSGTVADRIWARPAVTVIGIDCPPVVGATPSVQAGARALISLRVPPGQDAAEATKLLTAHLQAHTPWNARVTVDQVGQGQPFQADTSSPAYASMAEAMRIAYPGEEMQTAGMGGSIPLCNTLASLYPETEILLIGLSEPEAQIHAVNESVSPEELERLSLAEALFLTKYAAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMB2</accession>
    <name>A0A2G1XMB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07975</name>
        <name evidence="3" type="ORF">CYQ11_00410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52377">
        <property type="protein sequence ID" value="PHQ52377"/>
        <property type="gene ID" value="BLA24_07975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11579">
        <property type="protein sequence ID" value="PPT11579"/>
        <property type="gene ID" value="CYQ11_00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304952" evidence="1">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="12648" checksum="18229711F17C0832" modified="2018-01-31" version="1">MPRLRTTVTALAGAAAVFALTAAPAQAAPGDVTTTCANTATPAGYVDVNWGYSNSCGGQNFAPNIKQIKQLTGLPIGTVVQACGSTYYPTGWVQTSSYYSSSCVAFPNSGFNNNAWTLKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMJ5</accession>
    <name>A0A2G1XMJ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06805</name>
        <name evidence="4" type="ORF">CYQ11_26955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52484">
        <property type="protein sequence ID" value="PHQ52484"/>
        <property type="gene ID" value="BLA24_06805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16017">
        <property type="protein sequence ID" value="PPT16017"/>
        <property type="gene ID" value="CYQ11_26955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="400" mass="43654" checksum="EC01B2901FB34EAF" modified="2018-01-31" version="1">MRPIDVTPLIADPHGTYAALREAGPVHRAAGPDGRPAWLVTRYEDVRRALADPRLSLDKRNALPGNYAGFPLPPALDANLLNMDPPDHTRVRGLVAKAFTPGRVEKLRGPVRAVAGSLLDAVEPLGRADLLAAYAGPLPIIVICDLLGVPQADRVDFRAWTDALVTPDPERPHRTKEAVVGMMRFLTGLIERKRAEPADDLLSDLIQVQEDGDSLSPDELTSLAFLILFAGYENTVHLIGNAVLALLDHPGTLAELRKNPDGVGAALEELNRWDGPATLAIRRFPLEDVEIGGVRVPAGETVLLSIASANRDPRQFPGSDRLDLGRERSGHLAFGHGIHYCLGAALARMEAETALTVLLERCEEMELDVPRDALEWRPTIRARGLISLPVRWSSRRRTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN09</accession>
    <name>A0A2G1XN09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-N4-asparagine amidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07270</name>
        <name evidence="4" type="ORF">CYQ11_27425</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52561">
        <property type="protein sequence ID" value="PHQ52561"/>
        <property type="gene ID" value="BLA24_07270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16099">
        <property type="protein sequence ID" value="PPT16099"/>
        <property type="gene ID" value="CYQ11_27425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PTHR31104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304922" evidence="2">
        <location>
            <begin position="25"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="537" mass="57866" checksum="CCD3179865F78331" modified="2018-01-31" version="1">MRRLFLTLCAAALGLVLGMSPAAAAGPPPEFGTDWHDPVTAGPPVPTPGTTSCKATVADTEFRDYTPYKGTYLPPKGCGDRWNKVVLRLEGAVAGRQYDRLGYLHIGGVEVLRTSTPEPSPEGVAWNVEKDVTRYAATLRSRQPVEMLIGNLVNETYTGVIKVKVTLTFYAAEGSVEPAPAPDRVLTLDGAHTVGAAYEGTLTTPRNSERIVAEVYATGSGGECEEFWYLTVPDAAPYSCKAQDGPYREVRVAVDGKLAGIAAPYPTVWTGGWSNPFLWYVIPGPRAFDVRPVEYDLTPFAGQLNDGKPHTITVSVAGVPEGRSGWSTPTNILVWQDAGADRVTGALTTHREGAPRNTTALEQGAEYRLKADGGHALTVAGYLDTSHGRVGTTVTREVAATSLHRWTKGETTDGLQARWDDDETVTVAGRGPATVTHARRAYSMNGETSISGGRLRTVMTMGDRADSATLRAGAPPRWTRLDDTYTGDASYNQDVPRDQRHATGVSRERYRLQGSGVCYDRTLATAQGELTEDSRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN32</accession>
    <name>A0A2G1XN32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_06010</name>
        <name evidence="9" type="ORF">CYQ11_03535</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52657">
        <property type="protein sequence ID" value="PHQ52657"/>
        <property type="gene ID" value="BLA24_06010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12091">
        <property type="protein sequence ID" value="PPT12091"/>
        <property type="gene ID" value="CYQ11_03535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2425"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="2582" mass="269064" checksum="0A0D584822E61F6F" modified="2018-01-31" version="1">MTHGPDELSSDAPQVPWSTRLRELGPDERERLLLDLVRTAVTDVLGLAGPGAVAEGQAFHELGLDSLAAVNLHARLTADTGLRLPVTLAFDHPSPRALAAHLLAELLGTKPGDDTPVAALASDEPVAIVGMACRFPGGIASPEQLWELLAEGGETLGRLPADRGWDLDNLYDPHSGRPGTTYVDKGGFLDAARFDAGFFGVSPREALAMDPQQRVLLETSWEAFERAGIDPTTLRGTRTAVYVGAEAQEYGPRIAAAPDGMEGHLVTGTAGSVASGRIAYTFGLEGAAVTVDTACSASLVALHQAAQALRLGEATLALAGGVAVMSSPGGFVSFSRQQGLAADGRCKAFAATADGTGWSEGVGLLVLERLSDARRNGHHVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANAGLKPTDVDAVEAHGTGTKLGDPIEAQALLTTYGQEREAGKPLWLGSLKSNIGHTQAAAGVAGVIKMVMAMRAGVLPRTLHVDEPTPHVDWSAGAVELLADAQPWPETGRPRRAGVSSFGFSGTNAHAIIEEPPAAPAAEEEAPLPDAGDVTADVAPVVLSAASDHGLRARARDLHTRLAGHTDLSAVDVARSLAPATTRNRGAERAAVVAGNMTDLLDALDALADGRPTGRTLRGRAHTGDTTFVLPAGEGWRPATGRELRAAFPLYARAFDEACAHLDPYLEQPLREVLAGDAALLEQPLPADCAAFAHGVALYRLLQSWGLTPDRVTGYGVGELAAAHVAGVLKPADAAALVVAHGRALPQPDLGWLMELCTFAEPGVPVLSASTGAVEDVTDGAYWNRRLSEDGRRPLGLDRLREKDAGGEDEDRFVDLAGLAGFVGFTDPGSEDAGSGSEVEGLVRLVAALDTDGFSPRWEAFFTGWNAQLVDLGDAAEETCPVPWVLSGRTEAALREQAERLRAHVVSAAELSVVDVAFSLATTRAALEHRAVVVADDGPGFVRGLGALAAGKPAAGVYASGAAAEERAIAVLFSGQGSQRAGMGRELYEAFPVFAEALDAVCAEFDRVLERPLREVMFEQGEALDQTGFTQPGLFALEVALYRLVESWGVRPDYVTGHSIGELAAAHVAGVLSLADAVALVAARGRLMQALPTGGAMLAVGADEATVAAHLEGREAQVSIAAVNGPSSVVIAGDEDVVTELGETFAQAGHKTRRLRVSHAFHSPHMDAMLDDFRRVAEGLTYEQPRIPVVSNLTGQAEDAASADYWVRHVRGAVRFGEGVRWLEDQGVSVFLELGPDAVLSGMAPESLTGTPQLIPALRKDRPEPEALVAALGRLHVAGVTPDWAAFFAGRDARRVDLPTYAFQQERYWLNPSGSSDVAAAGLTPAEHPLLGAVVDVPDTGGLLVTGQLSTGTFAWLRDHAIGGSVLLPGTAFVDMAIWAGDLAGCGRLEELTLEAPLVVPERNSVAVRVVVGPDDGDGGRSVAVYSRPADALGEEPWVRHADGLLGQTAEHTGDDGFAWPPADAVPADLTGFYERLDENGYGYGPAFQGLRAAWTRGEDVYVEVALPEGTEPERFGLHPALLDAVLHGTDLAGGGESAGPRVPFAWSGVTLHAAGAGVVRAWLRPAGTDAVALAVVDTSGRPVLSVDSLVSRELTVAAPSSPGADSLYRLDWSPLAAPAESPGTAGWAQLADVGVKELSSYPDLAALPAESPAVVLAAVSGGEDGPAGATHRALGLVQQWLADPRHDASRLVVLTRGAVSTGVEEDVTDLPAAAVWGLVGSAQAENPDRFVLVDLDAPPGDAPELLAAAVASGEPKVAVRGGRLRVPRLARASAGVGLLPPADGSAWRVDSRERGTLDAVEIIPAPEGTADLAPDQVRVAVRAAGVNFRDVLIALGMYPGEAIMGTEAAGVVVEVGAGVTDLAPGDRVFGVIDRSFGPLAVVDRPFVAPMPEGWSYEQAASTPLVFLTAYFGLSDLGGLRSGESVLVHSGAGGVGMAAIQLARHLGAEVFATASEGKWDVLRSLGLDDDHIASSRSLDFEAKFAASTGGRGVDVVLNSLAREFVDASLRLLPRGGRFLEMGKTDIREPADVTGAHPGVAYTVFDLIDAGPQRIQGMLVELLALFGTGALVPLPVRTWDVRRAQDAFRFVSQAKHVGKVVLTMPRTLDAEGTVLVTGGTGTLGGVLARHLVAEHGVRHLVLTSRSGRDARGAAELEAELTGLGAEVTIAACDAADRAALAAVLDAIPATRPLTGVVHTAGVLDDATVGSLTPERIDSVFRPKADAALALHELTRDRDLAMFVMFSSSASVFGDAGQGNYTAANGLLNALAQHRRAHGLPAQALAWGFWEQRSALTAHLTDADVDRMARTGTAALSTEDGLALFDAAATVDEPLLVPIKLNTRALRDQGPALPSVLRGLVRPAVRRAAGTGAQVTGGGLTERLAGLNRTEQDELLLGLVRDTAAAVLGHGGAESVDVGRTFQELGFDSLTAVEFRNQLSAVTGVRLPSTLIFDYPKPGALSEYFAAQLLGEREKASAAVAVLADIDRLDAAIGEVDPEDEAAAQIAVRLQSVLSRWNTRHGTEAVTDADELESASADDLFDIIQNEFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNA4</accession>
    <name>A0A2G1XNA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_06185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52690">
        <property type="protein sequence ID" value="PHQ52690"/>
        <property type="gene ID" value="BLA24_06185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="445" mass="46588" checksum="AA8CDCE229AD6925" modified="2018-01-31" version="1">MRNIRATREFPLALRLLLLNQFGIDIGFYLLMPFLAAYLEQGLGMSAALVGLVLGARNLSQQGLFILGGSAADRLGPRVVIIAGCALRTVGFALFAFGSSLWLLLCASVLTGLAAALFYPAVRTYVALESGDRKAEAFALLNVYATSGSLIGLLLGSVLFLADFRLCALVAAAVFGLLTVAQAMVLPTRGVVEAGRSATVFADWREAFCNRRFLLFSFATTGMFTMENQLYLLLPEGALAASGWKGSAGVLLAAGALANMVFQLRITRALERNGGGTRWISSGLVVMGLSFLPPLLICGTEPPAGTKEAVARMVVMVLGSVLLFFGIMVAHPTAMELIPQFGRESLTGTYFGLFYVFSGLAATGGNAVVGRAMDLGHQVGMEWLPWVCCLSFGMASAGAVALLYRTGMLPGRTVVAAVPVAEGAGGGAAVVPRSGAPVVPMTPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNE6</accession>
    <name>A0A2G1XNE6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05795</name>
        <name evidence="9" type="ORF">CYQ11_02270</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52775">
        <property type="protein sequence ID" value="PHQ52775"/>
        <property type="gene ID" value="BLA24_05795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11877">
        <property type="protein sequence ID" value="PPT11877"/>
        <property type="gene ID" value="CYQ11_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_51K" evidence="6">
        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="NADH_4Fe-4S" evidence="7">
        <location>
            <begin position="315"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="498" mass="50620" checksum="E7F2354EDC911091" modified="2018-01-31" version="1">MTGPVPTLAAVGPPRLLAGLDQRPWLDRAAHLALHGAQPALSAGELTELAKNVGLRGRGGAGFPFARKLGAVTDALRRTGGAAAVVVNGTEGEPGCLKDTALLLHVPHLVLDGALLAATALGAEEVAVGVTRADVEQSVSRAAAERGPDEVGVRVVRLPERFVTGEGTALVRGVGGGPALPSGRKVRSSESGLGGLPTLVSNTETFAQLAVAARLGVPGYRELGLPEEPGTVLLTVAGAHVVETPTGLPLPYALELCGTGPGQGVLVGGYHGAWLSADRARAATVSRESVAAAGAAFGAGALLPLPEATCPVGETTRVARWLAAETAGQCGPCFQGLPALAEQLLEAAQGGGRRALEGVRARMRAVERRGACAHPDGTARFVASSLAVFAEDFEAHAVSGGCGRPVLGALPLPPGARGAAAVTAARAVRPSPRERLLVDWTLCGGHGLCADLLPGLLRLGPDGYPERAAIPVPARMRQRALRAVRRCPALALRLETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNL7</accession>
    <name>A0A2G1XNL7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05995</name>
        <name evidence="9" type="ORF">CYQ11_02470</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52810">
        <property type="protein sequence ID" value="PHQ52810"/>
        <property type="gene ID" value="BLA24_05995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11912">
        <property type="protein sequence ID" value="PPT11912"/>
        <property type="gene ID" value="CYQ11_02470"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="11"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="320" mass="34640" checksum="4CA5A2065CFA1070" modified="2018-01-31" version="1">MDERRWNRVVVTGGAGFVGSHVCERLLAEGCEVCCVDNLVTGSRANVARLLPHPGFRFVEADVSRPDGLAAVSAPVDLVLHLACPASPADYLRLPLQTLDVGSNGTRAALDLARRDAARFLLASTSEVYGDPLEHPQREQYWGNVNPIGPRSVYDESKRFAEALVTAYRRTHGTDTSIVRIFNTYGPRMRAGDGRAVPTFIRQALDGEPLTVAGDGSQTRSLTYVDDTVDGIVALAASGHPGPVNIGGGEETSVLDLARRIVDLTGSASVIRFVDRPADDPAKRRPDTTLARRELGWSPRVDGEEGLKRTVEWFARSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR1</accession>
    <name>A0A2G1XNR1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_04575</name>
        <name evidence="9" type="ORF">CYQ11_28955</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52853">
        <property type="protein sequence ID" value="PHQ52853"/>
        <property type="gene ID" value="BLA24_04575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11491">
        <property type="protein sequence ID" value="PPT11491"/>
        <property type="gene ID" value="CYQ11_28955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="110"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="32855" checksum="90665ADC02670E71" modified="2018-01-31" version="1">MSTTAEPLPAAARTDGDGGREAPTVVRRLLRRPSAAASLAVIALLAVLALAAPLITHWYGASPTAFDGKAVDQALGGLPRGTAGGIGGEHWLGVEPVSGRDVFARIVWGTRVSLLIAVLATLLSVTLGTFLGLLAGFLGGRTDTVIGRTMDLLMSFPSLIFMIALMAAAPGADRELLLVVVLGFFGWPYVGRIVRGQTMVLAHGEFVEAARALGARRRALLVREILPNLTGPVLVVATVSIPGCVATEAGLSFLGVGVRPPTPSWGQMIASAVPWYAADPAYFLIPGGFLFLTVLAFNVLGDAVRDELDPGSKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNS9</accession>
    <name>A0A2G1XNS9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">BLA24_04705</name>
        <name evidence="14" type="ORF">CYQ11_28825</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52870">
        <property type="protein sequence ID" value="PHQ52870"/>
        <property type="gene ID" value="BLA24_04705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11470">
        <property type="protein sequence ID" value="PPT11470"/>
        <property type="gene ID" value="CYQ11_28825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ52870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT11470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="9159" checksum="2CB3B7AA98B3A7C3" modified="2018-01-31" version="1">MNWRQYAACAEEDPDLFFPVGTGGPAIAQTEGAKSVCQRCPVREQCLRWAMESGQEYGVWGGTSELDRRALRLEAKRRAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP25</accession>
    <name>A0A2G1XP25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_04485</name>
        <name evidence="6" type="ORF">CYQ11_01745</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52963">
        <property type="protein sequence ID" value="PHQ52963"/>
        <property type="gene ID" value="BLA24_04485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16289">
        <property type="protein sequence ID" value="PPT16289"/>
        <property type="gene ID" value="CYQ11_01745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005308">
        <property type="entry name" value="OKR_de-COase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03709">
        <property type="entry name" value="OKR_DC_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00703">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="4">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="782" mass="85024" checksum="C3A46670C269710B" modified="2018-01-31" version="1">MGGGTVLFALSQDPLGEDSESGQLRRIREAVESQGLEVRWARTGTDARAVLRTEAGLAAAVVAWDLPHGERPDGGKDGTEPGGAAVLRQIARRFKDLPVLLVMTDGADDDLDHLPLWVSETVAGYVWPLEDTPGFIAGRIAGAARGYREAVLPPFFKALRRFDGSHEYSWHTPAHAGGVAFLKSPVGRAFFDYYGERLFRSDLSISVEELGSLFEHTGPVGEAERNAARIFGADRTYFVLHGNSTADRMVGHFCVSQDEIALVDRNCHKSVLHGLILSGARPVYLVPTRNGYGLAGPLPPAEIEAAGVGHRIARNALAGEATTRQAEYAVVTNSTYDGLCYDAVRVARAFAPSTPRLHFDEAWFAYARFHPLYEGRYGMSVGPDTFSGPDRPTVFSTQSTHKLLAALSQSAMVHVKPSPRAPVDHERFNEAFMMHGTTSPLYPAIASLDVAAGMMDGPQGHWLIDEAVTEAVRFRQAVVRTGRRVAAAGDRPAWFFGVWQPDSVTDPATGERYAFPDAPADLLRTQSSCWQLVPDADWHGFPGLGEGYCLLDPVKVTLTCPGIDAAGVWADQGIPARVLTAYLATRNIVVEKTDSYTTLILFSMGITKGKWGTLLDALMDFKALYDDDAPLDRVLPGLLAEHPRRYAGMTLAGLCQSMHDHLRRADLVSLLDTAFQELPEPVAPPQWCYQRLIRQGTERVRIADAADRVAAAMVTVTPPGIPVLMPGESVGGDDGPLLRYLGALEAFDREFPGFHSETHGVTRDPDTGDYQIECVRQDAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP78</accession>
    <name>A0A2G1XP78_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04035</name>
        <name evidence="3" type="ORF">CYQ11_07280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53055">
        <property type="protein sequence ID" value="PHQ53055"/>
        <property type="gene ID" value="BLA24_04035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12715">
        <property type="protein sequence ID" value="PPT12715"/>
        <property type="gene ID" value="CYQ11_07280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="153" mass="16172" checksum="4D58FD8D40E88E98" modified="2018-01-31" version="1">MGERSKTTFPQEILDQWAGSGLDLNALFSAGHLGERMSVDVSEASPERVVGTMPVEGNTQPYGLLHGGASAVLAETLGSVGAMLHGGPARIAVGVDLNCTHHRGVRSGLVTGVATPVHRGRTTATYEIVITDEHDKRVCTARLTCILRDNETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPK6</accession>
    <name>A0A2G1XPK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02055</name>
        <name evidence="3" type="ORF">CYQ11_04420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53150">
        <property type="protein sequence ID" value="PHQ53150"/>
        <property type="gene ID" value="BLA24_02055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12240">
        <property type="protein sequence ID" value="PPT12240"/>
        <property type="gene ID" value="CYQ11_04420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="45"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="474" mass="49336" checksum="EBA9EC824BA37B9C" modified="2018-01-31" version="1">MELPMTVSVENPLLTALGEVLPPHALLTDEAELARHSRDAAPFGAAGRPAVVVCPETVEEVQHVVRTARARGVAVVPQGARTGLAGAANAVTGCVVLSMTRMNRILEIDTGNRLVRCEPGVVTADLAAAVAGEGLCYPPDPASFETCTIGGNIATGAGGLCCVKYGVTADYVLGLTVVLADGEVLRVGRNTVKGVAGYDLTRLFVGSEGTLGVIVEATLALVPPRPPALALLARFASTADAGEAVGAIIREGHVPSALELLDRATTRAVAALGHPLLGGDRTEAAATLIVASDAPDARERVRAMTELCRDAKALSVTAAEDEEQTGQVLRARRMVMPALAAHAGAGDREVTAFIEDVAVPRARLAVLIEQIEQIAQEHDLFIATVGHAGDGNLHPTVVFDPADPSAVRRAKDAYDAIMAAALELGGTITGEHGVGTLKRDWLARELSPRSLRLHRDVKRLLDPEGLLNPGKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPN9</accession>
    <name>A0A2G1XPN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02265</name>
        <name evidence="3" type="ORF">CYQ11_04625</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53186">
        <property type="protein sequence ID" value="PHQ53186"/>
        <property type="gene ID" value="BLA24_02265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12278">
        <property type="protein sequence ID" value="PPT12278"/>
        <property type="gene ID" value="CYQ11_04625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="246" mass="24543" checksum="DFD73E5BCFCFDFA5" modified="2018-01-31" version="1">MRAGQQTGQVPRALRAGVFAAVCVLLAALGHAVMSGTPVPWWAIAAALSGTGGCAWFLAGRERGPLLITLATVGAQTALHSFFTVAQSVGRDAAQGAAVVTGGAAADPGPLATCGGGHGAAMAAPGAGGGPMDHAMTAGMEGMAGHGMMSMHAGHGALGMWSAHVLVAVVCGVWLSGGEQAAFRLGRAVGARLFAPLLLLFHDVPARSGPPRVRAGLGRAAQRLRQLLYADVIARRGPPTARVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPR6</accession>
    <name>A0A2G1XPR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02240</name>
        <name evidence="3" type="ORF">CYQ11_04600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53181">
        <property type="protein sequence ID" value="PHQ53181"/>
        <property type="gene ID" value="BLA24_02240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12273">
        <property type="protein sequence ID" value="PPT12273"/>
        <property type="gene ID" value="CYQ11_04600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="73" mass="6807" checksum="C8F39D26C93A4C3F" modified="2018-01-31" version="1">MTARPARPPLSPYAPLAGFVLLLAVLFGVSYAAGSAAGPVAPGMHRTGGGDAGGGAGTGGGSGRMGGMPGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPS5</accession>
    <name>A0A2G1XPS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_02305</name>
        <name evidence="5" type="ORF">CYQ11_04670</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53191">
        <property type="protein sequence ID" value="PHQ53191"/>
        <property type="gene ID" value="BLA24_02305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12283">
        <property type="protein sequence ID" value="PPT12283"/>
        <property type="gene ID" value="CYQ11_04670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="27588" checksum="390FCF809703235B" modified="2018-01-31" version="1">MSEERTGGGSRRLLTGVAWLALMLALWLWGHDTVEDPITAVPKTGDVAATGHPPAPGLPPVHEPLPGAGPQTLAIKALGLKAPIEPHGLDALGGVEPPPYERPNTVAWYQNGPPPGSTGAAVLVGHVDTKSSPAVFYELSNVKRGAKIDVTRNDGSVAEFTVENVATVENNHFDADKVYGAADTKRAELRLITCGGEYDRAHREYKANVVVTAYLTGTRQTAPDSGGTAGSSKPPAPSPSPALTPAPSGTPEGDEGGQGGQEEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPU0</accession>
    <name>A0A2G1XPU0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_02835</name>
        <name evidence="14" type="ORF">CYQ11_05130</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53265">
        <property type="protein sequence ID" value="PHQ53265"/>
        <property type="gene ID" value="BLA24_02835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12359">
        <property type="protein sequence ID" value="PPT12359"/>
        <property type="gene ID" value="CYQ11_05130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="12">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="23793" checksum="72707C261F69AC5C" modified="2018-01-31" version="1">MTTSALDRSDTDDTERDGPATGAVGGGRAFAWLLVVTGAMGLLASWVITLDKFKLLEDPNFVPGCSLNPIVSCGNIMSSDQAKAFGFPNPMLGLVAYGMIIAIGLALLTGSRFPRWYWLGMEAGCLFGVGFVTWLQYQSLYVIGSLCLWCCLAWVATIVMFWYVTVQNLRHGFIPAPEGLKRGLLEFHWVVPVLWIGVIGMLILTKWWWFWTGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPX6</accession>
    <name>A0A2G1XPX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP pyrophosphokinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">RelA/SpoT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_02860</name>
        <name evidence="9" type="ORF">CYQ11_05155</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53270">
        <property type="protein sequence ID" value="PHQ53270"/>
        <property type="gene ID" value="BLA24_02860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12364">
        <property type="protein sequence ID" value="PPT12364"/>
        <property type="gene ID" value="CYQ11_05155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="146"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="499"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="762"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="840" mass="93016" checksum="BF1E4F3C6F12B003" modified="2018-01-31" version="1">MPDEVQPLTAAQQDKPSSEAAAVSGAPTGRPQGTDGPPPKGEPRTGGAAQAQPARPQPPASSAPARQAPTPGPAPRPGSSSRVRARLARLGVQRSSPYNPVLEPLLRIVRGNDPKADTTTLRQIERAYQVAERWHRGQKRKSGDPYITHPLAVTTILAELGMDPATLMAGLLHDTVEDTEYGLDDLRRDFGDQVALLVDGVTKLDRVQFGEAAQAETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLKREKQEKKARETLEIYAPLAHRLGMNTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAVVTDEVQADLRAARIKATVTGRPKHYYSVYQKMIVRGRDFAEIYDLVGIRVLVDTVRDCYAALGTVHARWNPVPGRFKDYIAMPKFNMYQSLHTTVIGPSGKPVELQIRTFDMHRRAEYGIAAHWKYKQEAVAGASKIRTDVPKNAGKNQDTVNDMAWLRQLLDWQKETEDPGEFLESLRFDLSRNEVFVFTPKGDVIALPAGATPVDFAYAVHTEVGHRTIGARVNGRLVPLESTLDNGDLVEVFTSKAPGAGPSRDWLGFVKSPRARNKIRAWFSKERRDEAIEQGKDAIARAMRKQNLPIQRILTGDSLVTLAHEMRYPDISSLYAAIGEGHVAAQGVVQKLVQALGGEDAATEDIEETAPIRGRSKRRSSADPGVVVKGVDDVWVKLARCCTPVPGDPIIGFVTRGNGISVHRADCVNVDSLSQQPERILDVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRVLSDQHVNILSAAVQTSRDRVATSRFTFEMGDPKHLGHVLKAVRGVEGVYDVYRVTSARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ16</accession>
    <name>A0A2G1XQ16_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53281">
        <property type="protein sequence ID" value="PHQ53281"/>
        <property type="gene ID" value="BLA24_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="212" mass="22507" checksum="C98C69C8121A2B49" modified="2018-01-31" version="1">MSVNVLLPLALYYALRAQGTAQWQALLLSGVIPAAHALGSAVVRRRVEFFDFLVVVLLAISAATSLISGDPRVLLLKDAGLPAVLGLWILGTLGVSRPFAFTFGGALRDRAGAEAAELAWRDRPEFREALRGLTVVWGCGQLLDAALSTVAALTLPVDVVPVIGRFQSVALLGLVAVITVRRSRGFHARHGISLFGVRAVAEEPQAEVAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ82</accession>
    <name>A0A2G1XQ82_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000020">
        <property type="protein sequence ID" value="PHQ53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53398">
        <property type="protein sequence ID" value="PHQ53398"/>
        <property type="gene ID" value="BLA24_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GHL10" evidence="2">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="251" mass="29021" checksum="207ED90F162D349B" modified="2018-01-31" version="1" fragment="single">PEWAVPYGGKLYYNPGLPEVRRFVQDAMLDAVWRYDLDGVHFDDYFYPYPVAGQTFDDTAAYERYGAGFPDRAAWRRDNIDRLVRETGERIKRRKRHVRFGVSPFAVWRNRATDPLGSDTRAGVQTYDDLAADTRRWVREGWIDYIVPQCYWHIGFGPADYAKLLPWWAETVRGTRVQLYIGEALYRAGDPAQPAPWQDPGELSRHLDLARGRPEVLGNVFFSAKYVASDPVGAMARVVKDHYPHRARPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQD7</accession>
    <name>A0A2G1XQD7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00415</name>
        <name evidence="3" type="ORF">CYQ11_07425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53433">
        <property type="protein sequence ID" value="PHQ53433"/>
        <property type="gene ID" value="BLA24_00415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12737">
        <property type="protein sequence ID" value="PPT12737"/>
        <property type="gene ID" value="CYQ11_07425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="420" mass="46497" checksum="046E2A2065962E0F" modified="2018-01-31" version="1">MIAAVLLWGSIAIIVMAGCYNTTLFVLSRRRVRRDRGPRAERLYVFLLACLNEEKVLAESLARITSLPAGNFMALVIDDASDDGTAEIARAAGRSSQGRVQLLQRHLPDARRGKGAALNAGIRHLRESGLLDGRDPRDVIVCVVDADGRLDPHVVQAVDPYFDDPHTGATQIGVRMYNRHKGLLARLQDMEFVIYGDIFQTARRYFGSVGMGGNGQFMRLAALDTLGGPDGRGPWSDSLTEDLDLGVRLIARGWTNQHCTTAAVSQQAVLDVGRLVRQRSRWFQGHLQSANLVPLILREVPTRAAVDLMYHLSSPVLILLTSLLPLSFLVATAGTLIGSVEAGRPLFSPMFVLGPYVLSFTAAYAYGWVYSRRERNLGLTRAVLLSHVFVFYGYIWFAAGWWGLWRMLTGKQTWLKTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQN6</accession>
    <name>A0A2G1XQN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01085</name>
        <name evidence="3" type="ORF">CYQ11_08095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53555">
        <property type="protein sequence ID" value="PHQ53555"/>
        <property type="gene ID" value="BLA24_01085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12860">
        <property type="protein sequence ID" value="PPT12860"/>
        <property type="gene ID" value="CYQ11_08095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="324" mass="35086" checksum="19EB58A10E92B2C4" modified="2018-01-31" version="1">MRIAVTGSIATDHLMTFPGRFTDQLVADQLHTVSLSFLVDELDVRRGGVGPNICFGMGLLGLRPVLVGAAGADFSDYRAWLDRHGVDTASVHISEVLHTARFVCTTDTDHNQIASFYTGAMSEARQIELQPVADRVGGLDLVLIGADDPEAMLRHTEECRTRGIPFAADPSQQLARLDGDDIRQLVDGATYLFTNEYEKALIESKTGWTGEEILAKVGTRVTTLGAQGVRIERAGQPVVEVGCAQEEAKVDPTGVGDAFRAGFLAGVTWELSLERAAQVGCMLATLVIETLGTQEYELRRGHFMERFAKAYGHEAAAEVQAHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQP4</accession>
    <name>A0A2G1XQP4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00620</name>
        <name evidence="6" type="ORF">CYQ11_07630</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53469">
        <property type="protein sequence ID" value="PHQ53469"/>
        <property type="gene ID" value="BLA24_00620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12774">
        <property type="protein sequence ID" value="PPT12774"/>
        <property type="gene ID" value="CYQ11_07630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="37"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="16977" checksum="30075ACF076AC3F7" modified="2018-01-31" version="1">MAKKSRKQQTSGPTPAIVALEKAGTAFSVHAYEHDPAAASYGEEAAEALGVEPGKVFKTLVAEVDGELTVAVVPVSGSLDLKALAAAVGGKRAAMADPAAAERTTGYVRGGISPLGQRRRLPTALDASARSHPTICVSAGRRGLEVELAPDDLARLTGAVVAPIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQR1</accession>
    <name>A0A2G1XQR1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000010">
        <property type="protein sequence ID" value="PHQ53576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53576">
        <property type="protein sequence ID" value="PHQ53576"/>
        <property type="gene ID" value="BLA24_00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="66" mass="7015" checksum="828F174E41AD2177" modified="2018-01-31" version="1">MLKEVYNPKAVIPHAASLHQAFAHCAIFPTAASRRSLGRVSVPVWPVALSGRLPVVALVGHHPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9F6</accession>
    <name>A0A2G1X9F6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_30615</name>
        <name evidence="6" type="ORF">CYQ11_23710</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47863">
        <property type="protein sequence ID" value="PHQ47863"/>
        <property type="gene ID" value="BLA24_30615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15488">
        <property type="protein sequence ID" value="PPT15488"/>
        <property type="gene ID" value="CYQ11_23710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="162"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ47863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="279" mass="28577" checksum="75DDBC3865364017" modified="2018-01-31" version="1">MDAIISATQWASESAGERPPTLLDIRWQLGGPPGRPEYEAGHIPGAVYVDLDTELAGPAGRRGRHPLPDTGEFGAAMRRAGVCADRPVVVYDGGQGWAAARAWWLLRWAGHRDVRVLDGGLAAWTARGGELASGAAKPVTEGDFTPSPGALPLLDADGAAALARRGVLLDARAGERYRGEVEPIDPVAGHIPGAVSAPTTENVTADGHFRPPGELAGRFAALGAVPGAEVGVYCGSGVSGAHEVLALAVAGVPAALYAGSWSEWSADPQRPVATGAQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA29</accession>
    <name>A0A2G1XA29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArsR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32060</name>
        <name evidence="6" type="ORF">CYQ11_25120</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48080">
        <property type="protein sequence ID" value="PHQ48080"/>
        <property type="gene ID" value="BLA24_32060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15706">
        <property type="protein sequence ID" value="PPT15706"/>
        <property type="gene ID" value="CYQ11_25120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="152" mass="17128" checksum="262B9D6CD3C1118A" modified="2018-01-31" version="1">MDSIDRMILRELQSEGRLPNAELADRVGLTPSPCLRRVRQLEADGVIRRYAAVVDPARIGRSFEVFVCVELQKEDRATITAFEDRVRELRDVVEAYRLFGGQDYLLRIAVADISAYEHCYTNELATLPGVARLTSHLAMKAVVAERPRPVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA39</accession>
    <name>A0A2G1XA39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32120</name>
        <name evidence="6" type="ORF">CYQ11_25180</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48090">
        <property type="protein sequence ID" value="PHQ48090"/>
        <property type="gene ID" value="BLA24_32120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15716">
        <property type="protein sequence ID" value="PPT15716"/>
        <property type="gene ID" value="CYQ11_25180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="78"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="27683" checksum="125C210474BE8C44" modified="2018-01-31" version="1">MPPSAEPRPASTSGGVQSLERAFDLLERMADAGGEVGLSELATSSGLPLPTIHRLMRTLVACGYVRQQPNRRYALGPRLIRLGESSARLLGTWARPHLARLVAETGETANMALLDGDEVVYVAQVPSRHSVRMFTEVGRRVLPHSTGVGKALLAQSADDHVRALLTRTGMPAATEKTITTPEAFLAELAQVREAGFAMDDNEQEIGVRCLAVPVPNAPTSAAISVSGPAGRVTEAATERIVPLLREVAAELSAELAGTGAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA44</accession>
    <name>A0A2G1XA44_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pucL</name>
        <name evidence="8" type="ORF">BLA24_32095</name>
        <name evidence="9" type="ORF">CYQ11_25155</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48085">
        <property type="protein sequence ID" value="PHQ48085"/>
        <property type="gene ID" value="BLA24_32095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15711">
        <property type="protein sequence ID" value="PPT15711"/>
        <property type="gene ID" value="CYQ11_25155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="298" mass="33151" checksum="9FEEEF4E7F0B3D90" modified="2018-01-31" version="1">MTLGQNQYGKAQNHVVRIVRDGITHHIKDLTVSVALSGDMADVHLRGCNAKVLTTDATKNTVFAFAKEHGVESAERFGMHLARHFVASQEAVTSARVRIEEHAWERIEAPGGKPHSFVRAGRETRTAQITHDGEGWQILSGLKDLVVLNSTDSEFRGYVRDRYTTLPETTDRILATEVNARWRHAGTGGEPGGEAVRWDHSYATVRDHLLHAFAETYSRSLQETLYAMGSRVIDRCPGIDEIRLSLPNKHHFLVDLTPFGLENDNEVYHAADRPYGLIEATVLRDGAEAAIPVDLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA55</accession>
    <name>A0A2G1XA55_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32200</name>
        <name evidence="4" type="ORF">CYQ11_25255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48102">
        <property type="protein sequence ID" value="PHQ48102"/>
        <property type="gene ID" value="BLA24_32200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15728">
        <property type="protein sequence ID" value="PPT15728"/>
        <property type="gene ID" value="CYQ11_25255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="309" mass="31953" checksum="3B42BE4585E237B1" modified="2018-01-31" version="1">MLCGWSATVYTRPSLSLPKGVRSAGVRVRGWISRYRCEHRHAARYRDRAVLLAGDAAHVHPPTGGQGLDTGIADTMSLGWRLAAAVAAPATRGSSTPTPRSAGSPPPASCGSPAPCCTSTRPPRCGATPCAPWDWDVRGCRPSAGASPPPWPGCRSGARTRRPGTERSAGPRRTAARHDHEPPPPTVRGPARRSPRTPRTGVRHPGSPGGGHDPAPADGADRRLPAGAHRPSRRALPVTSGPLCACHPALPGGALAVAAPTAAVPAVPDVPAMGPALTQRPAAGYQLPQILGRNHGTRAGQYLCSRSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAH7</accession>
    <name>A0A2G1XAH7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32950</name>
        <name evidence="7" type="ORF">CYQ11_26000</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48228">
        <property type="protein sequence ID" value="PHQ48228"/>
        <property type="gene ID" value="BLA24_32950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15855">
        <property type="protein sequence ID" value="PPT15855"/>
        <property type="gene ID" value="CYQ11_26000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="22275" checksum="8A9CDEA92A2D3FBC" modified="2018-01-31" version="1">MSAGTTGPKRDTYRHGDLRNALIEAGLELARQGGPEAVVLRATTRQAGVVPNAAYRHFADRGALLHAVSQAAMARVARTMEAEQAALPPAADEAAAARARFRAVGTGYLRFAQEEPGLFRAAFHVPGDMTHAAADTAAGTGGKTPFELLGAALDDLVEAGLLPADRRPGAEFLAWSAVHGLAVLLIDGPLRGLHPSQAHDAGQHVIDMIERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAU0</accession>
    <name>A0A2G1XAU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32010</name>
        <name evidence="3" type="ORF">CYQ11_25065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48357">
        <property type="protein sequence ID" value="PHQ48357"/>
        <property type="gene ID" value="BLA24_32010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16783">
        <property type="protein sequence ID" value="PPT16783"/>
        <property type="gene ID" value="CYQ11_25065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="92" mass="9736" checksum="43DBA0381CD4BA5F" modified="2018-01-31" version="1">MYVPVRPCPTGFALRLFRTPLGTRTAVAFTTRRRLVDCLGPAVPSVRLALPAVSALAAPLGVTEVSVDPQLSAPPVRRSPEDTSPLLLSFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAU7</accession>
    <name>A0A2G1XAU7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_30580</name>
        <name evidence="6" type="ORF">CYQ11_23675</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48331">
        <property type="protein sequence ID" value="PHQ48331"/>
        <property type="gene ID" value="BLA24_30580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16755">
        <property type="protein sequence ID" value="PPT16755"/>
        <property type="gene ID" value="CYQ11_23675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23775" checksum="2A4B389870589D4B" modified="2018-01-31" version="1">MSTHAVCTAIRDDIVSGVLPPGGRLVEEILARRYGVSRVPVREALRTLASEGFVIIRRNAGACVAEPSEQEAADLLDVRALLEPLGAARAAQRRTEAHLKVLRGLVRLGQDRARTGRVGDLRPLADWFDETLAQASGSPSLATLLTQLRRKIAWVYAAEPSPRPTVDWETCGALVDAVARRDAERAGSLAAVRAQRSPGAYRLHRPGRAKRVVNTAGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB08</accession>
    <name>A0A2G1XB08_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29015</name>
        <name evidence="3" type="ORF">CYQ11_06460</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48424">
        <property type="protein sequence ID" value="PHQ48424"/>
        <property type="gene ID" value="BLA24_29015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12580">
        <property type="protein sequence ID" value="PPT12580"/>
        <property type="gene ID" value="CYQ11_06460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="23343" checksum="CFC2D53343C7C195" modified="2018-01-31" version="1">MAHTAHRIQDTAEEWRINASATPFTGNKTSVRTDEVVMPDGSVVTRDYQVHPGSVAVLALDDDMHVLVINQYRHPVRQRLWEIPAGLLDVPGENPLHAAQRELYEEAHVKAEDWRVLTDVYTTPGGCDEAVRIFLARGVSDVEGDRFAVEHEELDMQLARVPLPELVRGVLAGELHNNSLAVGVLAVAAALAGEGLDALRPADAPWPARPFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB62</accession>
    <name>A0A2G1XB62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29135</name>
        <name evidence="3" type="ORF">CYQ11_06340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48441">
        <property type="protein sequence ID" value="PHQ48441"/>
        <property type="gene ID" value="BLA24_29135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12563">
        <property type="protein sequence ID" value="PPT12563"/>
        <property type="gene ID" value="CYQ11_06340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="410" mass="43062" checksum="88664851FAFD388D" modified="2018-01-31" version="1">MFGIIRPCRHRLSEGMRTEWMAHLCGLCLALKGDHGQFARIATNYDGLVISVLVEAQSERAGADAWRRTAGPCPLRGMRGASVAQGEGARLAATVSLVLASAKMRDHVADGDGALARRLVAAAARKVAARWDRAGARTGSELGFDTAVLVDAVERQAGIESLAGPGTPLLEVTEPTETATAAAFGYTAVLAGRPGNREALEEAGRLFGRLAHLLDAVEDLAEDARTGAWNPVTATGAELAEVRRLCDDAVHGVRLALREVEFASKAQGKLAHLLLAHELERSVDRAFGTQAAARCGHQGHSGQPHPAGPEGAFGAPPVMPPPAPPEPPRRRRGLIAGCAVWTGLFCTGQVCCKDPYQDPWNGQPREGWCAKCADNCDGCGDGCDCCDCCDCCSKCGDGCDCCDCSCDCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB79</accession>
    <name>A0A2G1XB79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29505</name>
        <name evidence="2" type="ORF">CYQ11_05970</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48497">
        <property type="protein sequence ID" value="PHQ48497"/>
        <property type="gene ID" value="BLA24_29505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12504">
        <property type="protein sequence ID" value="PPT12504"/>
        <property type="gene ID" value="CYQ11_05970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043758">
        <property type="entry name" value="DUF5703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18963">
        <property type="entry name" value="DUF5703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="62" mass="7608" checksum="49AE319AE50C3B55" modified="2018-01-31" version="1">MPEYEFCDVYVPRGVSRKATTRLLTDHAEYGLWELDRLRLYPDGSRRVRLRRRIIRQIRATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB93</accession>
    <name>A0A2G1XB93_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29610</name>
        <name evidence="2" type="ORF">CYQ11_05865</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48514">
        <property type="protein sequence ID" value="PHQ48514"/>
        <property type="gene ID" value="BLA24_29610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12487">
        <property type="protein sequence ID" value="PPT12487"/>
        <property type="gene ID" value="CYQ11_05865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="231" mass="24451" checksum="8E0B31864450765A" modified="2018-01-31" version="1">MTSSIPAVDTRSAAPALQAVLLDMDGTLVDTEGFWWEVEVAVFAELGHQLLEEWREVVVGGPMTRSASFLIQATGAKIAVAELSVLLNTRFSQMIGRGVPLMPGARRLLAELAAHGVPTALVSASHREIIDRVLHTLGPQHFTLTVAGDELARTKPHPDPYLLAAARLGAEPGRCAVVEDTLTGVRAAEAAGCRVVAVPSVAPIPPAAGRTVVGSLEEVDLSFLRDMISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBN0</accession>
    <name>A0A2G1XBN0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">BLA24_29010</name>
        <name evidence="13" type="ORF">CYQ11_06465</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48579">
        <property type="protein sequence ID" value="PHQ48579"/>
        <property type="gene ID" value="BLA24_29010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16384">
        <property type="protein sequence ID" value="PPT16384"/>
        <property type="gene ID" value="CYQ11_06465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="307"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT16384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="548" mass="59862" checksum="377B59D75E0F7D81" modified="2018-01-31" version="1">MAAKPTTTKHLFVTGGVASSLGKGLTASSLGALLKARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHYERFLDVDLDGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITNEIKHRIRRMATDDVDVVITEVGGTVGDIESLPFLETVRQVRHEVGRDNVFVVHISLLPYIGPSGELKTKPTQHSVAALRNIGIQPDAIVLRADREVPTAIKRKISLMCDVDEDAVVAAIDAKSIYDIPKVLHAEGLDAYVVRKLDLPFRDVDWAQWDDLLDRVHQPDHEVTVALVGKYIDLPDAYLSVTEAIRAGGFANKARVKIKWVTSDDCKTPAGAKKQLSDVDAICVPGGFGDRGVDGKVGAITYARENKVPLLGLCLGLQCVVIEAARNLAGIEGANSTEFDPATAHPVISTMAEQMDIVAGEGDMGGTMRLGMYPAKLAEGSIVREVYDDQPYVEERHRHRYEVNNAYRGELEKKAGIVFSGTSPDNKLVEYVEYPREVHPYLVATQAHPELRSRPTRPHPLFAGLVKAAVKRQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBW7</accession>
    <name>A0A2G1XBW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_28815</name>
        <name evidence="14" type="ORF">CYQ11_06650</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48708">
        <property type="protein sequence ID" value="PHQ48708"/>
        <property type="gene ID" value="BLA24_28815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12611">
        <property type="protein sequence ID" value="PPT12611"/>
        <property type="gene ID" value="CYQ11_06650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="671"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="279"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ48708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="850" mass="92513" checksum="0ACA7AF6787F8DBA" modified="2018-01-31" version="1">MGHGVPELVLELNGQTWTLDPSRSYTLGRDPQGDMVLEDARVSWRHASLRWGGRAWVIEDHGSTNGTYVQGQRIHQLELGAGAVVHLGNATDGPRLNLSAAASPAADLYSAQTAMAAPVQPGAQPPQQYQQPDPQGWGHQPPQQQYQQPPQAQAWQQQPYVPPQAAPQQGQTTGGQAGAPPVYGDRSPTSFHQMAVGRVMRIGRALDNELVVSDLQVSRHHAEFRATSDGRFEIVDLGSHNGTYVNGQPVRQQIIGPQDIVGVGHSTFRMVGDRLEEFVDTGDVSFSARHLTVTVEGGKQILKDVSFGVPEKSLIAVIGPSGSGKSTLLKALTGYRPANQGDVLYDNRNLYKQFAELRQRIGLVPQDDILHKELTVRKALRYAAKLRFPGDTAPAEREARIDEVLRELKLDIHKDKKVTALSGGQRKRVSVALELLTKPSLIFLDEPTSGLDPGMDRDVMQLLRGLADDGRTVLVVTHSVAELALCDKLLVMAPGGSVAYFGPPDEALNFFGYETWADVFSAFENYRDYDWSGRWRGSQHYQMYAADIDAVAPQSVHVQPQMVRPPVPQSWGAQLWTLMRRYVSVIASDRGFLALMVILPAVLGGVSTVIPANFGLGPGPAKSAFQNRDAGTILLILAVGACFAGAANSVRELIKERVIYERERATGLSRSAYLMSKVVVLGMITVFQGALISVIGFGTRGAKMPKEGVLLTNLPQVEMALVIMALGFTSMMFGLIISSLVKTAEKTMPLLVMFAIVQVVFTGVLFQIFDKIGVEQLAWLMPSRWAIAAAGATADLNVLMPWPGAGPDPLWEHTAGQWIVDMGVLLGIGVACGVVVARLLRRHEPEVMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBZ3</accession>
    <name>A0A2G1XBZ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000158">
        <property type="protein sequence ID" value="PHQ48746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48746">
        <property type="protein sequence ID" value="PHQ48746"/>
        <property type="gene ID" value="BLA24_28155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013672851" evidence="2">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="135" mass="12798" checksum="AB47E77433F4DDD0" modified="2018-01-31" version="1">MSVRRSVVTSAVTSVPPSAVTSAAMTVVAVPVVASALAVTMTVAVSVVTSAVTTVARAVTTTVVVSAAMTVAMSVRRSVVTSAATTVAPAVTTTVAPVVPTGTTARAAVAATEAVATTVPVATAAATTGTATGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC55</accession>
    <name>A0A2G1XC55_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purU</name>
        <name evidence="5" type="ORF">BLA24_27440</name>
        <name evidence="6" type="ORF">CYQ11_18205</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48806">
        <property type="protein sequence ID" value="PHQ48806"/>
        <property type="gene ID" value="BLA24_27440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14546">
        <property type="protein sequence ID" value="PPT14546"/>
        <property type="gene ID" value="CYQ11_18205"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="97"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="293" mass="32868" checksum="874389FC89840087" modified="2018-01-31" version="1">MRRYWAMTTEQPQQYVLTLSCPDKQGIVHAVSSYLFMTGCNIEDSQQFGDRDTGLFFMRVHFGAEAPVTLEKLRASFAAVGDSFHMDWQIHLADDKMRIVLMVSKFGHCLNDLLFRSRIGALPVEIAAVVSNHTDFAELVGSYGVPFHHIPVTKETKPEAEARLLELVQAENVELVVLARYMQVLSDDLCKALSGRIINIHHSFLPSFKGAKPYHQAHERGVKLIGATAHYVTADLDEGPIIEQEVERVGHDLTPEQLVAVGRDVECQALARAVKWHSEHRVLLNGKRTVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC66</accession>
    <name>A0A2G1XC66_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27305</name>
        <name evidence="3" type="ORF">CYQ11_18350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48785">
        <property type="protein sequence ID" value="PHQ48785"/>
        <property type="gene ID" value="BLA24_27305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14566">
        <property type="protein sequence ID" value="PPT14566"/>
        <property type="gene ID" value="CYQ11_18350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="371" mass="39780" checksum="93475EA207CDFD72" modified="2018-01-31" version="1">MSLTGTPFFLTAIALVVLGLVLPLTLWGRIGGPKLVRHVTRIFMLLFAQATAIVLVFVIVNNSNGLFDNWADLLGTGDHVKVAADLGPDGTGGKSVKDEPKVVQPFKPASDKRMGPGVRETQLKGRISGVEGEVYVWLPPQYDDPAYKDKKFPVVEVLPGFPGSAKAWFGTLDVNTQLKPMMEKGEVAPFIIVAPRTTLLGDVDTGCANIPGKVNADTWLSVDVRKMVVDTFRVSDKPDGWAVAGYSAGAHCATKLAVAHPDRYRAGVSLSGYNDPSGEPASLTAKTPQLRDENNPWKMLQRAKTPPHVALFISGAEGDGYQGGLAIKQAAKAPTTVQVTMIPAGAGGHGTAVWKRQVPDVFRWLTKQVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCA2</accession>
    <name>A0A2G1XCA2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="3" type="ORF">BLA24_27730</name>
        <name evidence="4" type="ORF">CYQ11_17910</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48856">
        <property type="protein sequence ID" value="PHQ48856"/>
        <property type="gene ID" value="BLA24_27730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14497">
        <property type="protein sequence ID" value="PPT14497"/>
        <property type="gene ID" value="CYQ11_17910"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="244" mass="23976" checksum="F03EB4F539630D27" modified="2018-01-31" version="1">MRVLVVTAVAAERDAVTAAGPPPRELPLPGGSVLHRCPPAGPDGPALDVLAAGVGPAAAAAAAATALTAAALSGEPYDLVVTAGIAGGFAPGAPLGSLVVSEALVAADLGARTPDDGFLSVAELGFGTDVHRVPEALVDAVAGATGALRGEVLTVSTATGSAARAAELVRRHPAALAEAMEGFGAAEAAAAHRVPVLELRAVSNAVGPRDRAAWRIGEALAALTEAFRKLSTAPVLAEKAEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCD5</accession>
    <name>A0A2G1XCD5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_27810</name>
        <name evidence="8" type="ORF">CYQ11_17830</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48870">
        <property type="protein sequence ID" value="PHQ48870"/>
        <property type="gene ID" value="BLA24_27810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14483">
        <property type="protein sequence ID" value="PPT14483"/>
        <property type="gene ID" value="CYQ11_17830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="188"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="396"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="548" mass="60957" checksum="5234352F42182E6C" modified="2018-01-31" version="1">MSCLIVQSDKTLLLEVDHEQAEACRRAIAPFAELERAPEHIHTYRVTPLGLWNARAAGHDAEQVVDALVAHSRYPVPHALLVDIAETMARYGRLKLVKHPTHGLVLESTDRPVLEEILRSKKIQPLVGARIDPDTVAVHPSERGQIKQALLKLGWPAEDLAGYVDGEAHPIELHEDGWALRPYQRQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMARAKATTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTKRKGVYPHLELFDSRDWGLVVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDSERLAYATAETEEKYRYCATTATKRKVTEALVRKHRGEQTLVIGQYIDQLDELGEHLAAPVIKGETSNAQREKLFDAFREGELKVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHEARFYSVVARDTVDQDFAAHRQRFLAEQGYAYRIVDADSLLAGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT7</accession>
    <name>A0A2G1XCT7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23325</name>
        <name evidence="2" type="ORF">CYQ11_22750</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49030">
        <property type="protein sequence ID" value="PHQ49030"/>
        <property type="gene ID" value="BLA24_23325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15324">
        <property type="protein sequence ID" value="PPT15324"/>
        <property type="gene ID" value="CYQ11_22750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="20906" checksum="6F1EE8A461BD0D53" modified="2018-01-31" version="1">MSTTPPVLAAELAQAWADIQRFHPELPDLAAPESLIGESSSACGAELSFERLLHEAVHGIAAARGVRDTSRAGRYHNRRFLAIAEELGLDHSDEPHPSSGFSLVVLNPEARKRYRPTIERLQRALKAHSVATTADTSRTFRGPAARHGSSGGGVRVKAVCECGRNVRVVPSVLAQAPIMCGGCGQPFRIPEAVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD47</accession>
    <name>A0A2G1XD47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24015</name>
        <name evidence="3" type="ORF">CYQ11_22055</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49140">
        <property type="protein sequence ID" value="PHQ49140"/>
        <property type="gene ID" value="BLA24_24015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15210">
        <property type="protein sequence ID" value="PPT15210"/>
        <property type="gene ID" value="CYQ11_22055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="14770" checksum="F3E236DB5419DFF6" modified="2018-01-31" version="1">MTGTFTTRTVDVTTGSAETMHDLTNACSAFLREVAHGRDGLLNVFTPHATSGLAVIETGAGSDDDLLAALREVLRADDRWQDRHGGAGPGRDHMLPALVPPHATLPVVGGELELGTSQSVVLVTTGRDTPDRKVRLSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD57</accession>
    <name>A0A2G1XD57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24075</name>
        <name evidence="3" type="ORF">CYQ11_21995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49150">
        <property type="protein sequence ID" value="PHQ49150"/>
        <property type="gene ID" value="BLA24_24075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15199">
        <property type="protein sequence ID" value="PPT15199"/>
        <property type="gene ID" value="CYQ11_21995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="35118" checksum="E86F467CF0BB8949" modified="2018-01-31" version="1">MMRIHFTAADFALTRFAPGPAPLQELNAALMQMCVPGDELLFGRWRRRLLRSLPAAAGPLADLVPAGVAPRFLDVFDGSLGEGLETVRASRPDLVRSEIERVYAGHPSPAPLWVCDLHRGDADAWRLLGRAQRAAFETVLGAVWPVVQDLHRAEFTRRAVAVAEQGVGAQLTALVPGARLEEGVWEFAGPDEDVALRGRGLVLVPTFHWTGHPVVADLPGRPLHLTYPAGPGLPLSPAGADDPAGALAGVLGRTRVEMLLLLAEEHTTSGLAKRLGVSNATASAHTAALRGAGLITTVRAGRAVAHRRTALGGLLVGRGQPGGGAYELVRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC7</accession>
    <name>A0A2G1XDC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">M4 family peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Peptidase M4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_24590</name>
        <name evidence="12" type="ORF">CYQ11_21480</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49243">
        <property type="protein sequence ID" value="PHQ49243"/>
        <property type="gene ID" value="BLA24_24590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15105">
        <property type="protein sequence ID" value="PPT15105"/>
        <property type="gene ID" value="CYQ11_21480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304589" evidence="8">
        <location>
            <begin position="41"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="291"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="455"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="947" mass="98207" checksum="AA4394556C9A6788" modified="2018-01-31" version="1">MRKPRARSGRPAAKTGIAGAAALLGAAALVVSALPGQAAAAAHDSGPEMVPGKGTSTPSLVDGIREGVKAGGSAADAARGHLADKRSRYGIDRPDRDLKPLETVARGTSETVRLQQRHRGVEVLGGQYVVRMEKKDGKRVVTGTSGTYFTGLKTDVTAEVGEDLAVRRAVGATLAQLGGKALGKDDVAGRDGARTKAVGALSGTARGLVVLPKGAGVLTHHVTVRGTDPATGQPVLREVYVDAKAGYPVLQYSGIKTFGVPKAAGQDAAKAAGPGAGRAPADGPKNPGVAGSGVRYDGTTVELGLYFDTARGQYVMTDHARMWESSKNKISTWDARGKDVGETDGAWPQGIKEFGSAGPQFGKEATEAGAVDAHWAAGKVYDYYKKVHGRDSLDGRGMAIDSLVGVTNFGMPYVNAFWDGAKMVYGGGDEDYKTLSADLDVVGHEMTHGVVEHTAGLVYAGQSGALNEALADYFGNAIAVDAAGMPMDDPDAGLLGGNLCRNKSPRQCAFRDLNDGATTSKNFLGVGFGSDNGGVHLNSTIFSGALWDMREDLGRTLADKVVYKALAEYMSPLDGFTEGRNAVVAAAKALKVSAGDLKVITRSFNAHGIVPNWEQALGVDSDQLFGKLNTSGSGVGAGGGWWTTSKSNDDGTEAYSVWAGRADGKGAPKLMSPNDGRYHVNPATDGKSVVWTAYGPKGVDVLSRPLAGGPVKKLYGSNTADVGAVRVEGAVVAFETTDFFGSRHVGYLRTGDKEPTWVDGARSEVGTGLPSLSGGRVAYAKAYPEGDAYRSGVEVLDLRSGERKLMGQLGEPQAIGQTAITGKHVYWLADEVVDLGQTAVRRANLDGTGVVDISKEKGEGALHGSALTASDDAVTVTAEQPDSAYHNETMAKLWQFGADGSALGRVSCNRGEQTSAAAAGGKQVVWVDGTTGSTDLVTRTRPAGRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDG0</accession>
    <name>A0A2G1XDG0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glsA</name>
        <name evidence="6" type="ORF">BLA24_24780</name>
        <name evidence="7" type="ORF">CYQ11_21290</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49277">
        <property type="protein sequence ID" value="PHQ49277"/>
        <property type="gene ID" value="BLA24_24780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15072">
        <property type="protein sequence ID" value="PPT15072"/>
        <property type="gene ID" value="CYQ11_21290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="303" mass="32175" checksum="6CEBFF55248260E1" modified="2018-01-31" version="1">MDYQAVLEEVAAFAQPLVGRGQVADYIPALAEVDTGHFGMAVADVDGGVYGVGDWERPFSVQSISKAFSLALVLAEGGDKIWERVGTEPSGNPFNSLVQLEYEHGIPRNPFINAGALVVTDRLQTLTGDASTTMLEFLRAESGNPDVSFDATVAKSESEHGDRNAALAHFMASYGNLDNPVSTVLEHYFWQCSIEMSCRDLALAAGFLARHGLRADGTRLLPRREAKQVNAVMLTCGTYDAAGDFAYRVGLPGKSGVGGGIVAVIPGRCTLCVWSPGLDARGNSVAGVAALDHFTSLTGWSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDJ6</accession>
    <name>A0A2G1XDJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24685</name>
        <name evidence="4" type="ORF">CYQ11_21385</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49261">
        <property type="protein sequence ID" value="PHQ49261"/>
        <property type="gene ID" value="BLA24_24685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15087">
        <property type="protein sequence ID" value="PPT15087"/>
        <property type="gene ID" value="CYQ11_21385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="320" mass="33863" checksum="9A8061BDA50E1137" modified="2018-01-31" version="1">MFAAYAARIDRDQPLNGLVLGERPEPEARPGWTTVNVKAATLNHHDLWTLRGVGISEKVLPMILGCDAAGVDEDGNEVVVHSVIGQTGHGVGPDEPRSILTERYQGTFAERVSVPSWNVLPKPAGLSFEEAACLPTAWLTAYRMLFTNADVRPGQSVLVQGAGGGVATAAIVLGAVAGLRVFTTSRDEAKRKRAVELGAEAAFEPGARLPHRVDAVIETVGAATWSHSVKSLKPGGTLVISGATSGPNPPAAELNRIFFLELKVVGSTMGTKEELADLLSLCATKDVRPLIDSVLPLDRAREGFEKMSSGDLFGKVVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDJ7</accession>
    <name>A0A2G1XDJ7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisN</name>
        <name evidence="12" type="ORF">BLA24_03555</name>
        <name evidence="11" type="ORF">BLA24_24985</name>
        <name evidence="13" type="ORF">CYQ11_21085</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000045">
        <property type="protein sequence ID" value="PHQ53100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49313">
        <property type="protein sequence ID" value="PHQ49313"/>
        <property type="gene ID" value="BLA24_24985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53100">
        <property type="protein sequence ID" value="PHQ53100"/>
        <property type="gene ID" value="BLA24_03555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15037">
        <property type="protein sequence ID" value="PPT15037"/>
        <property type="gene ID" value="CYQ11_21085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ53100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="264" mass="28777" checksum="BEA2801077144097" modified="2018-01-31" version="1">MSDYHDDLRLAHVLADAADAATMDRFKALDLKVETKPDMTPVSEADKAAEELIRGHLHRARPRDAVLGEEFGSEGTGPRRWVIDPIDGTKNYVRGVPVWATLISLMVQGEGGYHPVVGLVSAPALGRRWWAAKESGAYTGRSLSSASRLQVSRVGRIEDASFAYSSLSGWEERGMLPGFLDLTRDCWRTRGYGDFWPYMMVAEGSVDICAEPELSLWDMAANVVIVEEAGGCFTGLDGRPGPHSGNAAASNGVLHDELLSYLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDK9</accession>
    <name>A0A2G1XDK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25050</name>
        <name evidence="3" type="ORF">CYQ11_21020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49324">
        <property type="protein sequence ID" value="PHQ49324"/>
        <property type="gene ID" value="BLA24_25050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15028">
        <property type="protein sequence ID" value="PPT15028"/>
        <property type="gene ID" value="CYQ11_21020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="478" mass="49919" checksum="046FE9B250040EFD" modified="2018-01-31" version="1">MSDTPFGFGLPPEEPENGDDGQKKGGGQGGGQGPANPFGFGGSAAGGDNPFAAMFGSMNPNDLGAAFQQLGQMLSYEGGPVNWDMAKQIARQTVAQGTADGSKDASVSAGERSAVEEAVRLADLWLDGVTSLPSGAGSAVAWSRAEWVEATLPVWKDLVDPVAERVGAAMGDVLPEEMQAMAGPLLGMMRGMGGAMFGTQIGQAVGVLAGEVVGSTDIGLPLGPVGKAALLPVNIAALGSGLGVPEDQVRLYLALREAAHQRLFAHVPWLRSHLFGAVEGYARGIKVDTSKLEDVVGQLDPTRPEQMQEALQQGMFQPEDTPEQKAALARLETALALVEGWVDAVVHAAAAPHLPSAGALRETLRRRRASGGPAEQTFATLIGLELRPRRLRDASRLWASLTDARGVDGRDALWEHPDMLPTAGDLDDPDGFVHREHLDFSELDKMLGEAAGRAKDAGTETGGESGEDGKGDKGEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDR7</accession>
    <name>A0A2G1XDR7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP</name>
        <name evidence="3" type="ORF">BLA24_25390</name>
        <name evidence="4" type="ORF">CYQ11_20685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49383">
        <property type="protein sequence ID" value="PHQ49383"/>
        <property type="gene ID" value="BLA24_25390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14968">
        <property type="protein sequence ID" value="PPT14968"/>
        <property type="gene ID" value="CYQ11_20685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="30888" checksum="5910BE7431E61B9A" modified="2018-01-31" version="1">MLRLGRREFGAHEPVIMAIVNRTPDSFYDQGATFQDEPALARVEQAVAEGAAIIDIGGVKAGPGEEVTAEEEARRTVGFVAEVRRRHPDVVISVDTWRHEVGEAVCEAGADLLNDAWGGVDPRLAEVAARYGAGLVCTHAGGVEPRTRPHRIAYEDVMADILRVTVGLAERALELGVRRDGIMIDPGHDFGKNTRHSLEATRRLGEMTATGWPVLVSLSNKDFVGETLDKPVKERVLGTLATTAVSAWLGAQVYRVHEVAETKQVLDMVASLAGHRPPAVARRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEB2</accession>
    <name>A0A2G1XEB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26475</name>
        <name evidence="3" type="ORF">CYQ11_19165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49573">
        <property type="protein sequence ID" value="PHQ49573"/>
        <property type="gene ID" value="BLA24_26475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14708">
        <property type="protein sequence ID" value="PPT14708"/>
        <property type="gene ID" value="CYQ11_19165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="128" mass="13708" checksum="B7ECD1DAD32F98CA" modified="2018-01-31" version="1">MLRGARPSDPAAWRVQPGGFGLAASTGRLIARMLGAVARHEAEHKAERKAERQQRPRRQATEAGRVGSAERFSPGIGGIEIRTHGRRSVGVDQVMPRSRHGRAGRPGVQSWAGATPTGQLTPVPPIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC1</accession>
    <name>A0A2G1XEC1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26530</name>
        <name evidence="5" type="ORF">CYQ11_19105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49583">
        <property type="protein sequence ID" value="PHQ49583"/>
        <property type="gene ID" value="BLA24_26530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14698">
        <property type="protein sequence ID" value="PPT14698"/>
        <property type="gene ID" value="CYQ11_19105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="283" mass="29204" checksum="9FE638E19B7E7056" modified="2018-01-31" version="1">MTPSDASGNRWSDLDRPPLNATALRRGLLRPGGLWTSFDVVQRTGSTNTDLVAAGGEEGAVLVAEEQSAGRGRLDRTWSAPPRSGLFFSVRLTPGPGVPPERWGWLPLLAGVATATALSAAAGVDTALKWPNDLLVTVGDEERKTGGILAERTGDSVVVGIGLNVSLRADELPVPGAGSLALAGAEVLDRDPLLRAVLRSLADWYERWRAAGGDPARCGLQETYAAGCATLGRTVRAELPGGQALVGEAVAVDGDGRLVLATADGVQQPVGAGDVIHLRPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC3</accession>
    <name>A0A2G1XEC3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">Histidine ammonia-lyase</fullName>
            <shortName evidence="5">Histidase</shortName>
            <ecNumber evidence="3 5 7">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">hutH</name>
        <name evidence="9" type="ORF">BLA24_26510</name>
        <name evidence="10" type="ORF">CYQ11_19125</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5 7">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 5 7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49580">
        <property type="protein sequence ID" value="PHQ49580"/>
        <property type="gene ID" value="BLA24_26510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14701">
        <property type="protein sequence ID" value="PPT14701"/>
        <property type="gene ID" value="CYQ11_19125"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="5">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="514" mass="53119" checksum="5BF7A4F233A1893C" modified="2018-01-31" version="1">MDMHTVVVGPAGTTADDVIAVARDGARVVVSDEALAAVAAARQVIDDLAAKPDPVYGVSTGFGALAVRHISPDLRTQLQRNIVRSHAAGMGPRVEREVVRALMFLRLKTLASGHTGVRPLVVETMAAILNAGITPVVHEYGSLGCSGDLAPLSHCALTLMGEGDAEGPDGVVRPAAQLLAEHRIEPVELREKEGLALLNGTDGMLGMLVMACADLARLITSADVTAALSLEALLGSEKVLAPELHAIRPHPGQAASAGNMLRVLTGSGLTGHHQDDAPRVQDAYSIRCAPQVAGAGRDTLAHARLVADRELAAAVDNPVVLPDGRVESNGNFHGAPVAYVLDFLAIAAADLASIAERRTDRLLDKNRSHGLPAFLAGDAGVDSGLMIAQYTQAALVSEMKRLAVPASVDSIPSSAMQEDHVSMGWSAARKLRTAIDALGKVVAVELVAATRAIELREGLVPGPAARAVIEAVRAAGVEGPGGDRFLAPDLAAAEAFVRAGKLVEAAEPLTGPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XED0</accession>
    <name>A0A2G1XED0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_26225</name>
        <name evidence="9" type="ORF">CYQ11_19415</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49529">
        <property type="protein sequence ID" value="PHQ49529"/>
        <property type="gene ID" value="BLA24_26225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14751">
        <property type="protein sequence ID" value="PPT14751"/>
        <property type="gene ID" value="CYQ11_19415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="47869" checksum="DCC07FA67F643DB2" modified="2018-01-31" version="1">MSRLPRWVGGVGSGLIRLAERLDARKAAAEHDTAAAPEAEAARATAPDRAPEPAAAPVPAYEPGPGDPPGHGHVASPVMAMRPDPVAAVPWGVRVAAEVGWRLLVLAGTLWVLMRVISAVRLVVLAFVAGLLITALLQPTVAWLKRHGVPRGVATAMTFVSGFIIMGLVGWFVVWQVTENLDGLSANVQHGITDLKQWLLDSPFHVTQDQINNIADNLSKAIGNTKDLTSAATEGVQVILEVLTGILLAMFSTLFLLYDGPRIWSWILKLVPAAAREGVAGAGPRAWTTLTAYVRGTVIVALIDAICIGVGIFFLDVPMAVPLAVFIFLFAFIPLVGAVVSGALAVVVALVTRDVFTAAMVLVVVLAVQQIEGHVLQPFILGRAVRVHPLAVVLSVAAGSMVAGIGGAVVAVPLVAVTNTVVGYLRAYAKENAARARLDVSPGEAAAVASPPPPPPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEF0</accession>
    <name>A0A2G1XEF0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="5" type="ORF">BLA24_26665</name>
        <name evidence="6" type="ORF">CYQ11_18970</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49606">
        <property type="protein sequence ID" value="PHQ49606"/>
        <property type="gene ID" value="BLA24_26665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14674">
        <property type="protein sequence ID" value="PPT14674"/>
        <property type="gene ID" value="CYQ11_18970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="382" mass="42482" checksum="254A16A593A3DA6D" modified="2018-01-31" version="1">MTSETTSPSTSRPSPEQIRRAPKVLLHDHLDGGLRPGTVVELAAAIGYDKLPETDPDKLGVWFREAADSGSLERYLETFAHTCAVMQSREALVRVAAECAEDLAEDGVVYAEVRYAPEQHLEAGLTLEQVVEAVNEGFREGERRARANGHRIRVGALLTAMRHAARALEIAELANRYRDSGVVGFDIAGAEAGFPPTRHLDAFEYLKRENNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVRIIDDIEIAEDGSVKLGRLASYVRDKRIPLEMCPTSNLQTAAANSYEDHPIGLLRKLHFRATVNTDNRLMSGTSMSREFEHLVKAFGYTLDDMQWFTVNAMKSAFIPFDERLAMINDVIKPGYAELKSEWLFRQTSTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEH5</accession>
    <name>A0A2G1XEH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_26755</name>
        <name evidence="9" type="ORF">CYQ11_18880</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49622">
        <property type="protein sequence ID" value="PHQ49622"/>
        <property type="gene ID" value="BLA24_26755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14657">
        <property type="protein sequence ID" value="PPT14657"/>
        <property type="gene ID" value="CYQ11_18880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304802" evidence="7">
        <location>
            <begin position="42"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="39098" checksum="E559F9EAAD27D47E" modified="2018-01-31" version="1">MKKFDKNKLILALAAPLLAIVAALVITSVIIASTGGDPFHAYEVMIDFGSKADSQVWIINKATPYYLSALAVAIGFRMNLFNIGVDGQYRIAAFFAAVVGGALTLPGFIQIPVIIIVAMAVGAVWAGIAGLLKVTRNVNEVISTIMLNAIGASVIGYFLQDGRLAEKEGNLIHTPYLPDSAHFFEIPTTPKPVYGFVVIAALAGAAYWFALNRTRFGFDLRTVGRSESAAQASGVSVKRMVITAMLLSGAMAGLVGMPTLLGVSYNYGTDFPTGIGFTGIAIALLGRNNPVGMALAALLWGFLERTGTQLEFEGYAQEIVGVIQGVIVLCVVIAYEIVRRYGLKVQQRKVGEELAAQARKSDKAEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEN7</accession>
    <name>A0A2G1XEN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24110</name>
        <name evidence="3" type="ORF">CYQ11_21965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49714">
        <property type="protein sequence ID" value="PHQ49714"/>
        <property type="gene ID" value="BLA24_24110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16712">
        <property type="protein sequence ID" value="PPT16712"/>
        <property type="gene ID" value="CYQ11_21965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="37628" checksum="8FBF668727FDFAC5" modified="2018-01-31" version="1">MGIPTEPVGSIPRPAELLTAMADHAAGRIGDDELAAAQDRAVRDTVRRLEETGSPVVTDGEQSKPSFATYPLAGLDGLAPDGVVIPFADGHQRQLPRLTAGPLRYAVHADRYVRAALRHATVPVKQAVIAPSALSLLYPPDGIDGYSREAFLDDLTAEAEADIRGCLGAGADSVQLDFTEGRLALKLDPSGGLLEQFVALNNRVLERFSAAEQARIGVHSCPGGDQDSTHSLNVDYAELLPRLLRLKAGRFAIQLASEPDPDAVLSVLAKHLPAHARVFVGVTDPVDPRVETPEQVRDRVLAAARHLPPDRLGTCDDCGFSPFADDTSTSRDTAFAKIRARIEGTALASGHLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XES4</accession>
    <name>A0A2G1XES4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_24870</name>
        <name evidence="7" type="ORF">CYQ11_21200</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49722">
        <property type="protein sequence ID" value="PHQ49722"/>
        <property type="gene ID" value="BLA24_24870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16705">
        <property type="protein sequence ID" value="PPT16705"/>
        <property type="gene ID" value="CYQ11_21200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="29772" checksum="7F553ED38A583EDB" modified="2018-01-31" version="1">MLGRVWPGATAVVLFVVFAFPVYWMFATALKPTPDIVSETPVWFPTSPTFEHFTKAVDADGFWTFVGNSLTVTLVAVGLSLVIALLASFAVARMRFKGRKSFILVMMMAQMAPWEVMTIAYYMIVRDADMLNSLPPLIAIYTVMVLPFTVLTLRGYVAAVPKELEESAMVDGCTRTQAFLKVIFPLLAPGLMATSLFGFITVWNEFPMVLILNKDAGSQTLPLWLTGFRTTFGDDWGATMAASSLFAVPILILFVILQRKAVGGLTSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEW9</accession>
    <name>A0A2G1XEW9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22755</name>
        <name evidence="3" type="ORF">CYQ11_14165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000152">
        <property type="protein sequence ID" value="PHQ49778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49778">
        <property type="protein sequence ID" value="PHQ49778"/>
        <property type="gene ID" value="BLA24_22755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16552">
        <property type="protein sequence ID" value="PPT16552"/>
        <property type="gene ID" value="CYQ11_14165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="227"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="35096" checksum="FF8C355D4C93012A" modified="2018-01-31" version="1">MQSPEQPPPQRVALVAFPGIRAFDVAVIAEVWGVDRTDRGGPPFELRRCAPGRAPVEMPGGLTLTPDRDLDWPATADLVVVPGVEDHLAPVPPPVRDALRDAHDAGIPVAALCGGAFVLAQAGLLDGRRAVTHWNLTTLLSATHPAVDVVPDALFVEDGGVWTAAGVAAGIDLCLHLVRTVHGAEAASTIARAMVTAPFRTGTQAQFIEHPAPASTIAERDASDALASVRERALRRLAEPLTVADLAGWAGMSPRSFARHFTASTGTTPIQWLLDQRVAAAQQLLERTGLPMPEIARRCGFGSEVTMRQHFAARLATSPRDYRRAFRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF55</accession>
    <name>A0A2G1XF55_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_19705</name>
        <name evidence="6" type="ORF">CYQ11_11090</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49868">
        <property type="protein sequence ID" value="PHQ49868"/>
        <property type="gene ID" value="BLA24_19705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13356">
        <property type="protein sequence ID" value="PPT13356"/>
        <property type="gene ID" value="CYQ11_11090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="8144" checksum="5CA81FA1B5C1CD22" modified="2018-01-31" version="1">MHMASKAEKIVAGLGGIDNIEEIEGCITRLRTEVSDPSLVDDAALKAAGAHGVVKMGTAIQVVIGTDADPIAAEIEDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFC3</accession>
    <name>A0A2G1XFC3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_20110</name>
        <name evidence="13" type="ORF">CYQ11_10680</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49933">
        <property type="protein sequence ID" value="PHQ49933"/>
        <property type="gene ID" value="BLA24_20110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13291">
        <property type="protein sequence ID" value="PPT13291"/>
        <property type="gene ID" value="CYQ11_10680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="120"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="627"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="708" mass="73572" checksum="60AE476BAECB4087" modified="2018-01-31" version="1">MFETVLVANRGEIAVRVIRTLRALGIRSVAVFSDADADARHVREADTAVRIGPAAAVESYLSIPRLLDAAARSGAQAVHPGYGFLAENAAFARACAEAGLAFIGPPAPAIELMGDKIRAKETVRAAGVPVVPGSTGSGLSDAELAAAARAIGMPVLLKPSAGGGGKGMRLVRDEALLGEEIAAARREARGSFGDDTLLVERWVDRPRHIEIQVLADGHGHVVHLGERECSLQRRHQKIIEEAPSVLLDDATRAGMGEAAVQAARACGYAGAGTVEFIVPGGDPSSYYFMEMNTRLQVEHPVTELVTGLDLVEWQIRVAAGERLGVAQEDVTLTGHAVEARICAETARVSGDRVDFLPSAGTVRLLREPAGDGVRVDSGLSEGVEVGTSYDPMLAKVIAHGPDRATALRRLRAALAETTVLGVDTNVGFLRRLLAHPSVVSGDLDTGLVDRDAAALVPAEVPQEVYVAGGLLRQAELSPAPAPSRNEGHAPRPPAGWVDPFSVPSGWRLGGEAAWTAHHFRVPGHAPVTVHVRGAASEAEFRLTPSGEDVPAASGSARLLPSRRPGGPLPESAPPPGPGTGERATLELDGTTRTLTVAHAPDGAVWLAHDGDTWHLLPYDPVQAALTGGAAGAHAGTLTAPMPGTVTLVKAAVGDEVTAGQSLLVVEAMKMEHVISAPHAGTVTELDVTAGSTVAMDQVLAVVTPREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFI4</accession>
    <name>A0A2G1XFI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20550</name>
        <name evidence="3" type="ORF">CYQ11_10230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50004">
        <property type="protein sequence ID" value="PHQ50004"/>
        <property type="gene ID" value="BLA24_20550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13218">
        <property type="protein sequence ID" value="PPT13218"/>
        <property type="gene ID" value="CYQ11_10230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="436" mass="45678" checksum="40D90CDB5C496E09" modified="2018-01-31" version="1">MDRLRASATTEPGRLRIIGAALAGLLVLFGAVTAWQVTDRAAAADAVVGRSQPLSADAADIYRSLADADTTAAGGFLAGGQEPAAVRRRYEQDISLASELLVRASANTSGSDTARRQISLLNAQLPLYTGLVETARATNRQGLPLGGAYLRYASERMREELLPAARGLYEAETGRLGADYARAEAWPWAALGTGALALGALGWAQRRNYLRTNRVLNRGMLAATGAATLTLLWLAAGHGLARAQLGDSHEHGARSLQVLNEARIAALQARGDESLTLVARGAVLTPGGDDAYEAGYLTGMHRLIGGTGPDAGAGSLLDRARSLADGSTGREPVTDAMEAVREWQRRHADARAADVGGYYERALPKVIGDKDSTAETFDRVDTALRRALVSEQGDFRRAADGGRDALTGLAAGAAVLAVLGAAGAVLGIGRRLSEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFJ6</accession>
    <name>A0A2G1XFJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20515</name>
        <name evidence="4" type="ORF">CYQ11_10265</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49997">
        <property type="protein sequence ID" value="PHQ49997"/>
        <property type="gene ID" value="BLA24_20515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13225">
        <property type="protein sequence ID" value="PPT13225"/>
        <property type="gene ID" value="CYQ11_10265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="134" mass="15525" checksum="2E0A509A5ED93E65" modified="2018-01-31" version="1">MKEIPRGTLQEQTFYEQVGGEETFRRLVHRFYQGVAGDPLLRPMYPEEDLGPAEERLVLFLIQYWGGPRTYSENRGHPRLRMRHAPFTVDRAAHDAWLRHMRDAVDGLGLAPEHERQLWDYLTYAAASMVNAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFM0</accession>
    <name>A0A2G1XFM0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20675</name>
        <name evidence="5" type="ORF">CYQ11_10105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50028">
        <property type="protein sequence ID" value="PHQ50028"/>
        <property type="gene ID" value="BLA24_20675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13194">
        <property type="protein sequence ID" value="PPT13194"/>
        <property type="gene ID" value="CYQ11_10105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="19822" checksum="F84DAFF4F8632AC4" modified="2018-01-31" version="1">MATAVAPVTRTGTVLADLLPASSAGRARVRDAALILGGAALTGVTAQIAVPVPGSPVPVSGQTFAALLVGTALGARRGFLSLALYAVAGMAGMPWFAEARSGAAFPSFGYVLGMLLAATVVGALARRGADRSVLRTAGTMALGSAVIYAVGVPYLALATHMPLSEAVAVGLTPFLIGDALKAALAMGALPAAWKLLGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFT1</accession>
    <name>A0A2G1XFT1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21095</name>
        <name evidence="4" type="ORF">CYQ11_09690</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50093">
        <property type="protein sequence ID" value="PHQ50093"/>
        <property type="gene ID" value="BLA24_21095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13127">
        <property type="protein sequence ID" value="PPT13127"/>
        <property type="gene ID" value="CYQ11_09690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="437"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="662" mass="68755" checksum="B774927E9D727F32" modified="2018-01-31" version="1">MPQAVRSVSVTTRPTSGNRRSVAETSTHGSGPPPDAPPGPRTGHPQEARPDPPPCPLSGPGVPAGPPPRPPAGSPPGPPTARTRLPGDVRAPSAARRFVRSVLAGWNAHAKVTDDATLLVSELVTNAVVHAGTSVDLECRIDAARGGDGGNLVVEVTDHHPARQFRARPCRRSADREGAAQAGHAGHGLRLLAELAETWGTAYRRTDKTVWFHLPTSPAAGPAAPAGPLSEQTLLGDLGVAEVLAPGAGSAPPGRRLGDHGHPRALSFLAEASELLSGQFDEDTVASLATQLAVPRLADWCAVWLDADSAPGAIRPAPRLSRVWHARESRVEPLRLALQRTPPALPAAGCAVPWPYGPDGPALACRLVAGRSGLGTLLLGRTGTAAMAGDVVSLTEDFARRVAQALASARRYTHQATISSILQRGLLPRGVARIPGVDRAVVYEPRGDASAGGDFYDVFTAGRGRWCFVLGDVCGSGPEAAVTTGLVRPWLRLLGKEGYGVGEVLDRLNRMLADETAEAEPGAAPRFLSLLYGELVPHGAGGGARCTLASAGHPLPLLLRPDGSVRAAAGPQMLLGVVEDVGYRAETFDLAPGDTLLCVTDGVTERKCGHRLFDDGDGLATALAGCAGLSAQDVAARIRRTVHGFSPTPPDDDLALLVLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFV8</accession>
    <name>A0A2G1XFV8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1929 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21205</name>
        <name evidence="6" type="ORF">CYQ11_09580</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50107">
        <property type="protein sequence ID" value="PHQ50107"/>
        <property type="gene ID" value="BLA24_21205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13112">
        <property type="protein sequence ID" value="PPT13112"/>
        <property type="gene ID" value="CYQ11_09580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304857" evidence="3">
        <location>
            <begin position="48"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1929" evidence="4">
        <location>
            <begin position="616"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="812" mass="87760" checksum="F7AB4979E0C1AD36" modified="2018-01-31" version="1">MTLNVTPPRRRARRERHRRRLSAATALLLASGASFGLLLATPGPARAGTNLVNNPGFEAVRATDTLPTCWESSGWGDNDATVTTTGQAHSGTRALTVSVTRRVTGDRKALMAEDPACAPGVAPSHQYDLSLWYKSTTPDASITVFRHDAKAGWQYWTDLKSLPVSEQYARVEVRTPVVPPGTDQITWGVSVYGTGTVTTDDYDMQDVTQAPPDDDCTAGKACTKGSWAVMPFRNPVRSMHSVVLHNGKVLLVAGSGNDPDLFKAGTFTSALYDPRTGAMKTIPTPVDMFCAGHVQLSDGRVLIMSGNKAYPAADGSHGYEGFKDSYVFDPAGESYVKTNDMNEGHWYPSATLLGNGDVISLGGLKEDSTGSVTAEKFSQAQQKWLPRTEVNQTWSYWGLYPSMILMQDGRLFYSGSHVFGNGTPGTGASVYDYDANKVTDVPGLQDKDHRDQSMSVLLPPAQDQRVLTMGGGNVNSNPEASRLTDIIDLKQPSPRYVPGPLLPQGTVDQGQGRKPETGAQGKMYVSAVLLPDGKVLETGGGLHDRADPVYEASFFNPVSNTFQAGLPTDPIPRTYHSSAFLLPDGRVMAVGDNPGNGTFDDHVSVYTPPYLYKGPRPQITSVANDRWQYASTQRVTVDRPVVKAELIRPAAVTHSSDPNQRFVDLPMTVGEDGRTIDLNVTSNPNMAPPGWYMLFAVDADGVPSVASWVHLGGPEAMAAPMVHGFAETMEKTPKRPEQPRASHPVSPGIAGCDRHYGAENVCVPTVFPKTVAETTRARCAWLKDHGYGPLKVNGRDDPLRLDPKATGWACRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG06</accession>
    <name>A0A2G1XG06_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">BLA24_21360</name>
        <name evidence="10" type="ORF">CYQ11_09425</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50135">
        <property type="protein sequence ID" value="PHQ50135"/>
        <property type="gene ID" value="BLA24_21360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13084">
        <property type="protein sequence ID" value="PPT13084"/>
        <property type="gene ID" value="CYQ11_09425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="7"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="460" mass="52411" checksum="C9A329ED5A4C4EDF" modified="2018-01-31" version="1">MAADKIDTIVSLSKRRGFVYPCSEIYGGQRAAWDYGPLGVELKENLKRQWWRYMVTSREDVVGIDSSVILASEVWVASGHVATFSDPLTECTSCHKRYRADHLEEAYEAKHGKLPENGLADVNCPNCGNKGQFTEPKQFSGLLSTHLGPTQDTGSVAYLRPETAQGIFTNFAQVQQTSRKKPPFGIAQMGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEQWQEYWMEQRWNWYTGLGLREENMRWYEHPKEKLSHYSKRTADIEYRFQFGGNEWGELEGVANRTDYDLGAHAKASGQDLSFFDQEAGERWTPYVIEPAAGVGRAMLAFLLDAYVEDEAPNAKGVMEKRTVMRLDPRLAPVKVAVLPLSRNPQLSPKAKGLAADLRKNWNIEFDDAGAIGRRYRRQDEIGTPFCVTVDFDTLDDNAVTVRERDTMKQERVSLDQIEGYLASRLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG50</accession>
    <name>A0A2G1XG50_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21835</name>
        <name evidence="3" type="ORF">CYQ11_08950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50213">
        <property type="protein sequence ID" value="PHQ50213"/>
        <property type="gene ID" value="BLA24_21835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13003">
        <property type="protein sequence ID" value="PPT13003"/>
        <property type="gene ID" value="CYQ11_08950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="189" mass="20512" checksum="5A015B1CBF8F6A92" modified="2018-01-31" version="1">MRTGEGEGVQSDQRVSIRRRGVQRLAEETWGSGRSIWSSDVGDRVLIVDRIEVGERPAPQWVAEALGLEPGAAVCVRSRRFVLDGKPVQLSTSYLPAELVAGSAITRADSGPGGTYARLAELGHKPVRFREEIRTRMPTAEEAEQLELPSGTPVVHICRTACAGGGRAVEVCEMTLDSASYVLEYEFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGL0</accession>
    <name>A0A2G1XGL0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20185</name>
        <name evidence="3" type="ORF">CYQ11_10605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50373">
        <property type="protein sequence ID" value="PHQ50373"/>
        <property type="gene ID" value="BLA24_20185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16479">
        <property type="protein sequence ID" value="PPT16479"/>
        <property type="gene ID" value="CYQ11_10605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304637" evidence="1">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="205" mass="20844" checksum="D0B9DC6BD36E84C1" modified="2018-01-31" version="1">MPEALFAFAVLCGACALAGCQAAAPPAPAAVARGEEVTAPAGPGRGAGATFLDRGTCAGRGRASFTEVDCLSGRATASVLARYFGPRSGGPRCPDTTDFVLHVTAVDTGTSETESVPEGYACMRNLRPPHPGDPGRGGGPLTVAGDCVYSERHGVVKETACDGSQPHAPEFEVAELARTRDDCPPSTDLYVQVGGAAPVGCARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGP9</accession>
    <name>A0A2G1XGP9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB</name>
        <name evidence="3" type="ORF">BLA24_20125</name>
        <name evidence="4" type="ORF">CYQ11_10665</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50371">
        <property type="protein sequence ID" value="PHQ50371"/>
        <property type="gene ID" value="BLA24_20125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16480">
        <property type="protein sequence ID" value="PPT16480"/>
        <property type="gene ID" value="CYQ11_10665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00189">
        <property type="entry name" value="tesB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="32161" checksum="3143B1B1B4B0DD9F" modified="2018-01-31" version="1">MTEPSTPLDDLLGLLDLEQIEQDIFRGTTDRPILVPRVFGGQVAAQALVAAGRTVPDDRAAHSLHSYFLRPGDPAVPIVYTVDRIRDGRSFTTRRVVAVQHGQPIFHLSASFQTYEEGLEHQEPMPAAPDPASLPTAAETLGAHAGLLGGPDVVRRILEAREAVDLRYVDGPPFASVGEPREPKSQVWFRTNGKLADDPMLHVCLATYVSDMTLLDSVLLAHGRGGWAVGDVVGASLDHAMWFHRPFRADEWLLYDQESPTAQGGRGLARGRIFTQDGRLAVSVIQEGLVRIPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT6</accession>
    <name>A0A2G1XGT6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_19125</name>
        <name evidence="6" type="ORF">CYQ11_11605</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000149">
        <property type="protein sequence ID" value="PHQ50442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009333493.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50442">
        <property type="protein sequence ID" value="PHQ50442"/>
        <property type="gene ID" value="BLA24_19125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13446">
        <property type="protein sequence ID" value="PPT13446"/>
        <property type="gene ID" value="CYQ11_11605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="24750" checksum="84AE93E7618B1CEA" modified="2018-01-31" version="1">MKGRVLVVDDDTALAEMLGIVLRGEGFEPSFVADGDKALAAFREAKPDLVLLDLMLPGRDGIEVCRLIRAESGVPIVMLTAKSDTVDVVVGLESGADDYIVKPFKPKELVARIRARLRRSEEPAPEQLAIGDLVIDVAGHSVKRDGQSIALTPLEFDLLVALARKPWQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKVEKDPERPEIVVTVRGVGYKAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH29</accession>
    <name>A0A2G1XH29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANTAR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_17010</name>
        <name evidence="5" type="ORF">CYQ11_16270</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50525">
        <property type="protein sequence ID" value="PHQ50525"/>
        <property type="gene ID" value="BLA24_17010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14221">
        <property type="protein sequence ID" value="PPT14221"/>
        <property type="gene ID" value="CYQ11_16270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="166"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="25757" checksum="F8CE589864A323F8" modified="2018-01-31" version="1">MDQQLLAKTFVELADNLVADFDLIDFLRLLTDRCVGMLDVSAAGVLLADRDGKLRVMAASDEQVRLLELFQLQNDEGPCLECFRTGVPVIVSDLGTVTARWPRFAVAARRSGFGAVQALPMRLRDEVVGALNLFSTAPGPFDPAAVPVAQALADVATISLLQQRTAQRSTVLNEQLQTALNSRVLIEQAKGKLAERQGIDMEQAFTALRGYARSHNRRLADVARALIDGSEPLAGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH84</accession>
    <name>A0A2G1XH84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_17425</name>
        <name evidence="9" type="ORF">CYQ11_15850</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50587">
        <property type="protein sequence ID" value="PHQ50587"/>
        <property type="gene ID" value="BLA24_17425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14158">
        <property type="protein sequence ID" value="PPT14158"/>
        <property type="gene ID" value="CYQ11_15850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="31199" checksum="8108140CDECD513F" modified="2018-01-31" version="1">MDEKDFLADRFEQHRGQLRAVAYRMLGSLAEAEDAVQEAWLRLSRTDTSDVENLGGWLTRVVGRVCLDMLRSRASRGEESLDVRLPDPVVSGEDVKDPEHEALVADSVGLALIVVLETLTPAERLAFVLHDMFAVPFEDIAPLVGRTPAAARQLASRARRRVRGEAPAPDADLTRQREVVSAFLAAARSGDFDALVAVLDPDVVARSDGGALRPGAVVRGAAAVAGQAMSFARFAAVARPALVNGTAGVVSFADGQPMSVLAFTITGGKIVEIDILADPERLRRLDLAVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHD0</accession>
    <name>A0A2G1XHD0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_17675</name>
        <name evidence="15" type="ORF">CYQ11_15600</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50627">
        <property type="protein sequence ID" value="PHQ50627"/>
        <property type="gene ID" value="BLA24_17675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14118">
        <property type="protein sequence ID" value="PPT14118"/>
        <property type="gene ID" value="CYQ11_15600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="489"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ50627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT14118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="527" mass="58011" checksum="A25A6C1A6B67FB21" modified="2018-01-31" version="1">MNLALAPETLARWQFGITTVYHFLFVPLTISLAAITAGLETAWVRTGKEKYFHATKFWGKLFLINIAMGVVTGIVQEFQFGMNWSDYSRFVGDVFGAPLAMEALLAFFFESTFIGLWIFGWDKLPKKIHCACIWIVAVGTILSSYFILAANSWMQHPVGYTIDQATGKARLTDIWAVLTQNTTMVVVLHTLTAAFLTGAAFVVGVSSFHLWRAKRKQIRGEELGEKQRKQLPAMLVSLRVGLVVAVIAGLGTAVNGDELGKVMFEQQPMKMAAAEALWETQTPAPFSVFAVGDVSKGHNSVEIEVPGLLSFLAHNNFSEAVPGINDIAAQEAARYGGDPQDYIPSIFMTFWGFRLMIGFGMTSFVAALIGLWTTRKKFWLAPGLRTAENEIPRLMLTRTREMSPFFTKWSWRIGILTMGLPLIANSFGWIFTEMGRQPWAVYGLMKTGDAVSPGVSQGEVIASMTVFTLLYAILAVVEVKLLVKYGKAGPDTDERPPAKDPRLRLPSGGAGGAGQPEDADKPMTFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHG4</accession>
    <name>A0A2G1XHG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_17925</name>
        <name evidence="6" type="ORF">CYQ11_15350</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50673">
        <property type="protein sequence ID" value="PHQ50673"/>
        <property type="gene ID" value="BLA24_17925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14072">
        <property type="protein sequence ID" value="PPT14072"/>
        <property type="gene ID" value="CYQ11_15350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="101"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="41106" checksum="A31F52A90725271C" modified="2018-01-31" version="1">MSERRRGLGRGLGALIPPAPKGSDQSGPAVLPGTTSPTAMPVLTAERGVAAAKVTTLPLEEARASRETGSHDAVSRETDGKADVRPEETRSLGEAAGAHFAELPLDSITPNPRQPREVFDEDALAELVTSIREVGLLQPVVVRQLAPERYELIMGERRWRACREAGLERIPSIVRATDDEKLLLDALLENLHRAQLNPLEEAAAYDQLLKDFNCTHDELADRIGRSRPQVSNTLRLLKLSPAVQRRVAAGVLSAGHARALLSVDDSEEQDRLAHRIVAEGLSVRAVEEIVTLMGSRPKAAGKAKGPRAGARISPALSDLASRLSDRFETRVKVDLGQKKGKIVVEFASMDDLERILTTLAPGEGRVLEQKLSAEDEGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHW7</accession>
    <name>A0A2G1XHW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18865</name>
        <name evidence="3" type="ORF">CYQ11_14415</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50823">
        <property type="protein sequence ID" value="PHQ50823"/>
        <property type="gene ID" value="BLA24_18865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13919">
        <property type="protein sequence ID" value="PPT13919"/>
        <property type="gene ID" value="CYQ11_14415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="105" mass="11394" checksum="3F9991E80CCD233B" modified="2018-01-31" version="1">MAQRVVVTLSDDIEGGEAAETVMFGLDGKSYEIDLNPANAKKLRAVLEPYMEAGRKQSRSGKAYRRTAVAPDPAAVRAWARSNGMEVPPRGRIPKKVYEAFNAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHW9</accession>
    <name>A0A2G1XHW9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">BLA24_18795</name>
        <name evidence="10" type="ORF">CYQ11_14485</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50817">
        <property type="protein sequence ID" value="PHQ50817"/>
        <property type="gene ID" value="BLA24_18795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13925">
        <property type="protein sequence ID" value="PPT13925"/>
        <property type="gene ID" value="CYQ11_14485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="416" mass="42714" checksum="B7B6297456E07333" modified="2018-01-31" version="1">MKVLVIGGGAREHALCRSLSLDPHVTALHCAPGNAGIAEVAETHPVDARDGAAVTALALSLGADLVVVGPEAPLVAGVADVLRERGIPVFGPSAQAARLEGSKAFAKDVMAAAGVPTARSYVCTTPAEIDAALDAFGAPYVVKDDGLAAGKGVVVTSDLTAAREHALACDRVVIEEFLDGPEVSLFAVTDGETVLPLQPAQDFKRALDADEGPNTGGMGAYSPLPWADPKLVDEVLETVLQPTVDELRRRGTPFSGLLYAGLAITSRGVRVIEFNARFGDPETQVVLARLRTPLAGVLMNAATGELAAQTPLRWSDDAAVTVVVASHNYPGTPRTGDVVEGLADAAGVEDAYVLHAGTAHDAEGRVVSAGGRVLSVTATGTDLAAARARAYEAVSRIRLDGSHHRTDIAAKAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHY6</accession>
    <name>A0A2G1XHY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain protein CspD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18985</name>
        <name evidence="5" type="ORF">CYQ11_14295</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50840">
        <property type="protein sequence ID" value="PHQ50840"/>
        <property type="gene ID" value="BLA24_18985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13902">
        <property type="protein sequence ID" value="PPT13902"/>
        <property type="gene ID" value="CYQ11_14295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7332" checksum="A3085AAE2655BACE" modified="2018-01-31" version="1">MATGTVKWFNSEKGFGFIEQDGGGPDVFAHYSNITSNGFRELFEGQKVSFDVTQGQKGLQAENIVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIT3</accession>
    <name>A0A2G1XIT3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NADPH-flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15160</name>
        <name evidence="3" type="ORF">CYQ11_12910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51110">
        <property type="protein sequence ID" value="PHQ51110"/>
        <property type="gene ID" value="BLA24_15160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13666">
        <property type="protein sequence ID" value="PPT13666"/>
        <property type="gene ID" value="CYQ11_12910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="50"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="21745" checksum="4740C7874FD7F27A" modified="2018-01-31" version="1">MAAVAIRYLRSTGSRAAPGPPVDPLPRPELRAVGADEVPPPTPREFRNVLGHFASGVTVVTAPGEDDLPPAGFACQSFTSLSLDPPLVAFMVARTSTTWPRIARAGVFCVNVLGAGQKSLCEGFAVSSSQTADKFSGVPYEPAPATGSPRLGGVPAWIDCTIQAVHTGGDHLVVVGRVEALGADESAATAGPLLFHRGTFGAFDAFGPTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIY1</accession>
    <name>A0A2G1XIY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15465</name>
        <name evidence="4" type="ORF">CYQ11_12610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51160">
        <property type="protein sequence ID" value="PHQ51160"/>
        <property type="gene ID" value="BLA24_15465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13617">
        <property type="protein sequence ID" value="PPT13617"/>
        <property type="gene ID" value="CYQ11_12610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="29178" checksum="48B045A85D2839FC" modified="2018-01-31" version="1">MFYFLFKSVVLVPLLKWLFRPRVEGAEHLPGSGAAIIAGNHLSFSDHFMMPVMVKRRITFLAKMEYFTGRGLKGRLVAAFFRGIGGIPVDRSGRQAAQAAVDTALGVLERGDLLGIYPEGTRSHDGRLYKGKVGVAEMALRSGAPVIPCAMIGTFEAQPTGRRLPRLVPITIRFGEPLDFSRYAGMEDHRAVLRAVTDEIMYAILKLSEQEYVDTYATEARAASQAVPPNTGRTGTGGDRGDHGGRTGRPVHVRAVRPRSRQATRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ10</accession>
    <name>A0A2G1XJ10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TatD family deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15800</name>
        <name evidence="3" type="ORF">CYQ11_12275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51217">
        <property type="protein sequence ID" value="PHQ51217"/>
        <property type="gene ID" value="BLA24_15800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13559">
        <property type="protein sequence ID" value="PPT13559"/>
        <property type="gene ID" value="CYQ11_12275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="32460" checksum="744087521EA3559E" modified="2018-01-31" version="1">MAATASKHTPAGGERKKNDDKGAPPPLPAPLSVPVADSHTHLDMQQASSVEDALAKAASVGVTTVIQVGCDLAGSRWAAETAERHASVWATVALHPNEAPRIVLGDPDGWSRQGTREPGGDAALDAALEEIDRLAALPQVRGVGETGLDRFRTGPEGMAAQERSFRRHIDIAKRHGKALVIHDREAHDDVLRVLAEEGAPETVVFHCYSGDAAMAKVCADAGYYMSFAGNITFKNAQPLRDALAVAPLDRILVETDAPFLTPAPYRGRPNAPYLIPVTLRAMAAVRGVSEDALATAVAANTARAFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ77</accession>
    <name>A0A2G1XJ77_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03089 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16345</name>
        <name evidence="2" type="ORF">CYQ11_11730</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51308">
        <property type="protein sequence ID" value="PHQ51308"/>
        <property type="gene ID" value="BLA24_16345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13466">
        <property type="protein sequence ID" value="PPT13466"/>
        <property type="gene ID" value="CYQ11_11730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="26211" checksum="736D9734BFD44FF0" modified="2018-01-31" version="1">MNATDRTPADLLRSALAADPSRPLVTFYDDATGERVELSVATFANWVAKTANLLQGDLAAEPGDRLALLLPAHWQTAVWLLACSSVGVTAEIGGDPATADLVVSGPDTLEEARACSGERVALALRPLGGRFPEPPAGFTDYALEVPGQGDRFAPYAPVDPDAPALVVGGTGLTGTEVVERARTDARQHGLRPGSRMLSGLPYDHWEGLSAGLLAPLAAGGSVVLCRHLDRLSDGALEQRRESERVTVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJP1</accession>
    <name>A0A2G1XJP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51446">
        <property type="protein sequence ID" value="PHQ51446"/>
        <property type="gene ID" value="BLA24_13640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="53" mass="6146" checksum="FDEF27A560C6ADBD" modified="2018-01-31" version="1" fragment="single">MDLFASFVHLRPDGRAQAEQPAFDVERDGWQLMTFHGETDADVHADHWEVHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJQ0</accession>
    <name>A0A2G1XJQ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13265</name>
        <name evidence="3" type="ORF">CYQ11_00985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51478">
        <property type="protein sequence ID" value="PHQ51478"/>
        <property type="gene ID" value="BLA24_13265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11660">
        <property type="protein sequence ID" value="PPT11660"/>
        <property type="gene ID" value="CYQ11_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="124"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="35003" checksum="FDCB0C24F9F484ED" modified="2018-01-31" version="1">MNAVEFAAAQWTRATGAGVDPHEYRRVTDDLTSVADWGPSFLRTGHGYLQRAQAARSSVSAGEYLLMAARWFHLATLAPYERAHLAATEADHALSRALTVLEPEARRVSGEGFTGWLRGPADAPGTVVVVPGLDSTKEEFLDLVSALLARGLAVFAMDGPGQGVLAATTTLRPEYEQVVGRVIDALGVARIGLVGLSLGGYFAARTAALEPRVAAVATVSGPFRLDWRELPPPVKDIMARRTGGADEARAFADQVDLADLASRIAAPLLVVDGERDVIPGVTNGERLAGLAPHGTYLSVPHGDHLLGNARPDWLPHVSDHITHTLRGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK09</accession>
    <name>A0A2G1XK09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13300</name>
        <name evidence="3" type="ORF">CYQ11_01020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51540">
        <property type="protein sequence ID" value="PHQ51540"/>
        <property type="gene ID" value="BLA24_13300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16270">
        <property type="protein sequence ID" value="PPT16270"/>
        <property type="gene ID" value="CYQ11_01020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="147"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="40967" checksum="3CAAC8CBED38824F" modified="2018-01-31" version="1">MPVELSALVRRCATALGMDTALIYLVDLQQRLLVPLDERHEPLPVDGSSAGWAYRTVSLRVADVDDGVIVWVPLVDGAERLGVLAVQSANLDGPRLRRSRMLADLLAMAITSKRAYSDWLVARTRIAPMRLHAEMMRAFLPPRTIGNSECVSTAVLEPAYELGGDAFDHSVVKNVLHTAIFDAMGHNLASGLTTSVALAGARNARRSGADLPELVDTIDQTLAQWLPDQFCTGVLCELDVSNGALRWINCGHPPPLLIRDERVIDHALANTSQPPMGLPFQLAPVTREVHETALEPGDRVLLYTDGVTEARSEGGMEFGLDRFTDFIIRSTASGQRPAEVLRLLIHAILDHERNDLRDDATILLFEWRPQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK24</accession>
    <name>A0A2G1XK24_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12810</name>
        <name evidence="2" type="ORF">CYQ11_17165</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51576">
        <property type="protein sequence ID" value="PHQ51576"/>
        <property type="gene ID" value="BLA24_12810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14368">
        <property type="protein sequence ID" value="PPT14368"/>
        <property type="gene ID" value="CYQ11_17165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20189" checksum="C368D6762B8019BF" modified="2018-01-31" version="1">MSAEHRRRLRERYLAAPVTPAPEPWRPVLEHGTPIGGLLGIGFAVDPGTGHDLVMVVSSGGHGLFDAVTGEKTARDRDPDPKTCTPDAHPDLACPGLGPVAGTPVRIAGLFGGGLHGTTADGWTVDVVSPEWPRDRVILSVDGGAHDGPPGGTWWHLFHSDHSQLRATGFSPSGRTLAVATSSGLALWTRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK40</accession>
    <name>A0A2G1XK40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NADPH-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12830</name>
        <name evidence="3" type="ORF">CYQ11_17185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51580">
        <property type="protein sequence ID" value="PHQ51580"/>
        <property type="gene ID" value="BLA24_12830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14372">
        <property type="protein sequence ID" value="PPT14372"/>
        <property type="gene ID" value="CYQ11_17185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="21444" checksum="F7EA058E42407EE6" modified="2018-01-31" version="1">MPDSTYRLAVIVASTRAGRFGPTVANWLARQTAQRDDIEVDVIDLADHPLPVHLTREPGPEDAAALAAVTPRLAAADAFVVVTPEYNHSYPASVKNLIDWHYTQWQAKPVAFVSYGGLSGGLRAVEHLRPVFAELHAVTIRETVSFHSPWGKLDDTGSHLDEEAGAAAQAAAKVMLDQLSWWAVSLREARAARPYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK47</accession>
    <name>A0A2G1XK47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51624">
        <property type="protein sequence ID" value="PHQ51624"/>
        <property type="gene ID" value="BLA24_13100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="143" mass="15608" checksum="D160A3D6DCFE684A" modified="2018-01-31" version="1">MRGRWLTAAGALTYPLYLLHERLGWLVIGHLGGRLPRWLLLSGLVTGMVLAAWVVHCCVERPLARRLGHALRRAVADMRSVSSGQARVSAGQTEIRPCQTKESRACETPVTAPAARGVSACGGLHTMSRLSQREPTQSQERTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKC3</accession>
    <name>A0A2G1XKC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_11370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51688">
        <property type="protein sequence ID" value="PHQ51688"/>
        <property type="gene ID" value="BLA24_11370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="281" mass="28476" checksum="7F39784791632AF4" modified="2018-01-31" version="1">MAPRLPHPPRPDPRRALRALPALLLTTLALAGPLLAPHSVDTPVTAPYAPPGGAALLGGDQLGRDVLSRLLHGGSALAASALLVAVVVTAVAAVIGCFAVLSRRLGGLVERTADVAILLPAVLGVMLLAMAWPGGGRWTVVLAAVVLGVPYAVRVVAGAAAPLATAGFVEAAAAGGEHLTHLALREILPNLRAVVAVLFGLRFVEAVYVVSMAGFLQIGPQPPAADWALMIRENAGGILLNPWAVVAPSITIGLLAISVNLATTARPAAGARRGRPDVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKE0</accession>
    <name>A0A2G1XKE0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_13000</name>
        <name evidence="6" type="ORF">CYQ11_17360</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51609">
        <property type="protein sequence ID" value="PHQ51609"/>
        <property type="gene ID" value="BLA24_13000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14402">
        <property type="protein sequence ID" value="PPT14402"/>
        <property type="gene ID" value="CYQ11_17360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="33261" checksum="05F4F56637835891" modified="2018-01-31" version="1">MTDLTYRPGRTAVEAVGLGMRYRRRWALRDCSFRLPAGRVCALVGPNGAGKSTLLALAAGLGRPAEGSLRVLGGAPSDGAVRPRVAYVAQDKPLYPHFTVAETLALGARLNPGRWDAAVAERLVRAGGLSPDARAGSLSGGQRTRLALALAFGKRPELLLLDEPMSDLDPLVRHEMTAALMAEAAEYATTVVMASHVLAELEGVCDYLLLVADGRVRLAGEVEDLISAHRLVMGRYEDVGTPREFAAHTIVEARTTGRQFTALIRPDGPVGGHWEVAEPSLEELLLAHLRAPGAPALLAPSAEPRAGARPAGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL3</accession>
    <name>A0A2G1XKL3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11980</name>
        <name evidence="3" type="ORF">CYQ11_03220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51794">
        <property type="protein sequence ID" value="PHQ51794"/>
        <property type="gene ID" value="BLA24_11980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12040">
        <property type="protein sequence ID" value="PPT12040"/>
        <property type="gene ID" value="CYQ11_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045383">
        <property type="entry name" value="DUF6528"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20138">
        <property type="entry name" value="DUF6528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304836" evidence="1">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="34228" checksum="8BB1C6F7D53C9019" modified="2018-01-31" version="1">MAAVLAVLLILAATGAAQARERGAPRAPSSSPIVAADQTTRSVLVLDSSRSRWDAEDDDDPGVLWSWSADRRAGLADLDPGTSWSNPSEVKFRSLGGKRYLLATASGGLAAVVGYPGREVYWATDTGRGNAHSIELLPDGNVAVAASTGGFVRLYAAATGSRATRHAQVPLAGAHGVHWDPRTRLLWAVGSRQLVALEAGGEEDDPTLTVVRRVTLPTRNGHDLAPVLASPGRLWVTTGSAVYQYSTAEQAFVPYALQSRVSAPGIKSVGDDPRTGQVLVTRPEPGHACSWCTTTLVLYQPDGARTLLRGGIYKARWWTTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKP0</accession>
    <name>A0A2G1XKP0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11995</name>
        <name evidence="3" type="ORF">CYQ11_03235</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51797">
        <property type="protein sequence ID" value="PHQ51797"/>
        <property type="gene ID" value="BLA24_11995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12043">
        <property type="protein sequence ID" value="PPT12043"/>
        <property type="gene ID" value="CYQ11_03235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304837" evidence="1">
        <location>
            <begin position="35"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="14079" checksum="61786644AB3F7687" modified="2018-01-31" version="1">MFRTFALRGRKVPAAVLAATVLGGSLLVTGPAQAVPPTRPYGTSTAVKGLNERSYPSTDASVRGVIKFHSQVGVRCKVHAQEVAGNSVWYLLRDRATWVAAKYVENTGDVPLCKAVNRNAMDDSPESHNAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKS1</accession>
    <name>A0A2G1XKS1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12165</name>
        <name evidence="3" type="ORF">CYQ11_03405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51827">
        <property type="protein sequence ID" value="PHQ51827"/>
        <property type="gene ID" value="BLA24_12165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12074">
        <property type="protein sequence ID" value="PPT12074"/>
        <property type="gene ID" value="CYQ11_03405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="90" mass="9367" checksum="B1971E8AE9B81EB8" modified="2018-01-31" version="1">MVRTPLTPWERQRGERLGALLRAARGKRSMVAVAADAGLSPETLRKIETGRAPTPAFFTVAALASVLGISLDDIAAACGEHPEAGQALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL90</accession>
    <name>A0A2G1XL90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10050</name>
        <name evidence="4" type="ORF">CYQ11_02520</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000105">
        <property type="protein sequence ID" value="PHQ52024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52024">
        <property type="protein sequence ID" value="PHQ52024"/>
        <property type="gene ID" value="BLA24_10050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11922">
        <property type="protein sequence ID" value="PPT11922"/>
        <property type="gene ID" value="CYQ11_02520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045512">
        <property type="entry name" value="DUF6480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20088">
        <property type="entry name" value="DUF6480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="75" mass="7628" checksum="8BB6B56AE258E936" modified="2018-01-31" version="1">MTTASPEPDTPRTPGQEGGVPPTETPPGEDSTAGAGPRETYNPTRGWAKGPVIAIGALVVVFAVTVIIWAALVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLA2</accession>
    <name>A0A2G1XLA2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10045</name>
        <name evidence="3" type="ORF">CYQ11_02515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000105">
        <property type="protein sequence ID" value="PHQ52023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52023">
        <property type="protein sequence ID" value="PHQ52023"/>
        <property type="gene ID" value="BLA24_10045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11921">
        <property type="protein sequence ID" value="PPT11921"/>
        <property type="gene ID" value="CYQ11_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="317" mass="32285" checksum="700DB52E651F1DF3" modified="2018-01-31" version="1">MTAPDGRPRLLVLRALGLGDLLAAVPALRALRGAFPGHELVLAAPPELAPAAAATGAVDRLLPACAPGRAVPRALAWRGPPPEVAVDLHGNGPPSHRLLLALRPGRLLAFAHPGTPSVAGPAWCPHEHERERWCRLLRSYGIAADPTDLALPRPAGTSPAPGAVVLHPGAASAARRWPADRYAAVARGLLERGHRVAVTGGPGEDALVARVAVPGAAAFPGGLPFGVLSALVAGAGAVVSGDTGVAHLAVAHGTRSVTLFGPVPPALWGPPPSPRHTALWHPGPPGNPHGRRPDPLLLRIRPEEVLAALARGEAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLV1</accession>
    <name>A0A2G1XLV1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08630</name>
        <name evidence="2" type="ORF">CYQ11_03885</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52222">
        <property type="protein sequence ID" value="PHQ52222"/>
        <property type="gene ID" value="BLA24_08630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12155">
        <property type="protein sequence ID" value="PPT12155"/>
        <property type="gene ID" value="CYQ11_03885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04793">
        <property type="entry name" value="LanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033889">
        <property type="entry name" value="LanC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="451" mass="47018" checksum="986B4603A4DE63F4" modified="2018-01-31" version="1">MRSVVVNRGESEVALLEFDARAAEVARAVAGRLAAFAGAAVETSGDGSAAHGSSLADGYPGIALALLHAGRTLDEPRLVDAAQALLRRSAQATAEEPLAGPGLYAGTAGFASVLLDFSVYDRRYLPSLRRIADRLGEQIAATPRLEPGAGLPVSDFDVISGAAGQLAAAVRLSTALDASPGDPVRVAAERLTEYLLRLTEPDDRRRFGWFTSPDYYPAYPGYEDQAPHGMYNLGFAHGLPGVISALCAAAAAGIGGPGPAERLAQTTAWLVENRLRDEVPGAAWPNLLRADEETGLPVAPLGQHPARAAWCYGAPGIGIALLSASKVLGDTALEATAAGALQRVVDWAPDERTVFSPNLCHGHAGLLAVYRRAHAVTGSASFRAMAEDSLSAVLSLADEARPYVVTDEPRRGEFADDPGLLNGAAGVLLALCGALAPQAAEWDELFFLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY9</accession>
    <name>A0A2G1XLY9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08755</name>
        <name evidence="3" type="ORF">CYQ11_04015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52243">
        <property type="protein sequence ID" value="PHQ52243"/>
        <property type="gene ID" value="BLA24_08755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12176">
        <property type="protein sequence ID" value="PPT12176"/>
        <property type="gene ID" value="CYQ11_04015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017078">
        <property type="entry name" value="UCP036978_PHPhdr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036978">
        <property type="entry name" value="UCP036978_PHPhdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="337" mass="36942" checksum="B82DE54A38DC357F" modified="2018-01-31" version="1">MEPVEALERIAFLLERSQAPTYRVKAFRTAASVVSATLDEELRRRAANRSLTELKGIGPKTAAVVADALAGEVPDYLARLEEEAGAPLTEGGLDLRAALRGDCHMHSDWSDGGSPIEEMARAARDLGHEWAVLTDHSPRLTIARGLSPERLRQQLDVVAEVNEHLGDGFRLLTGIECDILTDGALDQEPELLERLDVVVASVHSKLRMDAESMTRRMVAAVANPLVDVLGHCTGRLHGGKGRPESEFDAAMVFAACARFGTAVEINCRPERLDPPRRLLRRALDADVLFSIDSDAHAPGQLDWQIHGCARAEECKVPAERVITTWTADRLLAWTRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM25</accession>
    <name>A0A2G1XM25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000089">
        <property type="protein sequence ID" value="PHQ52305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52305">
        <property type="protein sequence ID" value="PHQ52305"/>
        <property type="gene ID" value="BLA24_08330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="386" mass="41571" checksum="5D1507AB70098354" modified="2018-01-31" version="1">MAGLARVRVTTLTRPTDSRVPIALTQPPRPSEILACAVAAREPVRAVHYFADGESITPLPLPLGGPGESNDDEAVPGPVADAKCLDAVIRTGEGEPRLWFYGTQCLWDGEGASPQDIGSAFPDLPEDFSSQLDAVTVLADPASDDAYELFFFKGETFYHRAYTSTDRAFVPQAESRGVRSLISEAFPGLSPQCQVSPDAVVVIGGVFFFMKGTRTEPALWRREDDPLHVLLVPLFEGDPAQAPPGDAFDVPPDVLDSVVGVVEASRLLGERLRVGTPRYHRFGIAATVRPWSSAAADQERTRRATERALRRFFHPTAGGPDGRGWPWGRRVHAGDVFTVLEAVPEVRGTTEVSLFVGDGAVPSVEVSDGGLVLVDDMVINVDITEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM38</accession>
    <name>A0A2G1XM38_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08495</name>
        <name evidence="3" type="ORF">CYQ11_03750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_045934404.1">
        <property type="nucleotide sequence ID" value="NZ_NHZO01000093.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52199">
        <property type="protein sequence ID" value="PHQ52199"/>
        <property type="gene ID" value="BLA24_08495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12132">
        <property type="protein sequence ID" value="PPT12132"/>
        <property type="gene ID" value="CYQ11_03750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="8538" checksum="EA5007C97E9C4046" modified="2018-01-31" version="1">MTNPFEDADAHYLVLVNDEGQHSLWPTFVEVPDGWTKVFGEAPRPECVEFIEKSWTDMRPKSLVAAMQDGKGADAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM72</accession>
    <name>A0A2G1XM72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07730</name>
        <name evidence="3" type="ORF">CYQ11_00160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52338">
        <property type="protein sequence ID" value="PHQ52338"/>
        <property type="gene ID" value="BLA24_07730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11541">
        <property type="protein sequence ID" value="PPT11541"/>
        <property type="gene ID" value="CYQ11_00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="33986" checksum="73D1536BCB5A1CFB" modified="2018-01-31" version="1">MWWMLQLALIAIVAGAGIADRWSSGFDSWWLMGVSAVSAVLGMVALTWRGVVVQPRWVGPLVGLVFGTGVVGMGVALAVTAPSRPMGSRVLFLAGASYVVLAGIWLLVRQWSWRTAITWLLPVVLPLVLGVFPGIGLVVHTFYLDAFDLRLEDIEIPVVYQVVASLKVIAAMSMWLLAPAFWGYAKHFHLAIRDRWVGHLMLLFIALCSFVAGPWMLAAEPAGEAGQRAVAAAAAGRAPAAYFGIKPEWVCVAPVGRAAETAVEGGEFQPEHPYLMLGDADGKAVLWDPKERHALKISMSKIKVVPSEGKAPAHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM79</accession>
    <name>A0A2G1XM79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07820</name>
        <name evidence="2" type="ORF">CYQ11_00255</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52352">
        <property type="protein sequence ID" value="PHQ52352"/>
        <property type="gene ID" value="BLA24_07820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11554">
        <property type="protein sequence ID" value="PPT11554"/>
        <property type="gene ID" value="CYQ11_00255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="76" mass="8764" checksum="B98C9AD8F6E0FFEA" modified="2018-01-31" version="1">MPHPIADRHLTELVDTWEYDLLADALPWSAWENRDTMRDELAAWLVHHAPARLRADGASPDLQERIRLLGLPETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM80</accession>
    <name>A0A2G1XM80_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07960</name>
        <name evidence="3" type="ORF">CYQ11_00395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52374">
        <property type="protein sequence ID" value="PHQ52374"/>
        <property type="gene ID" value="BLA24_07960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11576">
        <property type="protein sequence ID" value="PPT11576"/>
        <property type="gene ID" value="CYQ11_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="143" mass="15883" checksum="EF2973D02EF0C7E1" modified="2018-01-31" version="1">MSMIKQFQVTFDCAQPARLAAFWCEVLGYVVPRVPEGFATWEEYHHSLPPEDEIYFACTDPSGVGPRVLFQRVPEGKVVKNRVHLDVRVGTGLVGDERLATLEAECARLMGLGAKHVLTQRADGVNESCITMQDIEGNEFCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMB3</accession>
    <name>A0A2G1XMB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat-shock protein Hsp20</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_07850</name>
        <name evidence="5" type="ORF">CYQ11_00285</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52356">
        <property type="protein sequence ID" value="PHQ52356"/>
        <property type="gene ID" value="BLA24_07850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11558">
        <property type="protein sequence ID" value="PPT11558"/>
        <property type="gene ID" value="CYQ11_00285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="143" mass="15881" checksum="3B40DDDF1C00C28B" modified="2018-01-31" version="1">MLMRTDPFRELDRLAQQLMGPGTWSRPSAMPMDAYREGDQYVVAFDLPGVTADAIDIDVERNMLTVKAERRPVTKADDVQMELSERPLGVFSRQIVLADTLDTEHIQADYDAGVLTLRIPIAERAKPRKISIGAGSGHKEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMD1</accession>
    <name>A0A2G1XMD1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08120</name>
        <name evidence="1" type="ORF">BLA24_08975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000094">
        <property type="protein sequence ID" value="PHQ52195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52195">
        <property type="protein sequence ID" value="PHQ52195"/>
        <property type="gene ID" value="BLA24_08975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52397">
        <property type="protein sequence ID" value="PHQ52397"/>
        <property type="gene ID" value="BLA24_08120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="198" mass="21520" checksum="B064C559177B0B7F" modified="2018-01-31" version="1">MLTLTHQEWDAAALRLLGDPYVFAATGPRRHEDWTHDVLAVLHREVPDPRGRVRLDMDRTNTARHELPAYPFDPPAAGEMPGLLYRLEAEAAVAALAVMSEEWQAEPAPVRTRPDREAVLAAARILLGRYGPAAQYWTNATAAASDPAPDFVAAGLQGTCSNTFLTSAYLNGLDLFHDLGLIAVSGDEVGVFWSIGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN72</accession>
    <name>A0A2G1XN72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06420</name>
        <name evidence="3" type="ORF">BLA24_06440</name>
        <name evidence="1" type="ORF">BLA24_11915</name>
        <name evidence="4" type="ORF">CYQ11_03155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000080">
        <property type="protein sequence ID" value="PHQ52629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000080">
        <property type="protein sequence ID" value="PHQ52631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51781">
        <property type="protein sequence ID" value="PHQ51781"/>
        <property type="gene ID" value="BLA24_11915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52629">
        <property type="protein sequence ID" value="PHQ52629"/>
        <property type="gene ID" value="BLA24_06420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52631">
        <property type="protein sequence ID" value="PHQ52631"/>
        <property type="gene ID" value="BLA24_06440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12028">
        <property type="protein sequence ID" value="PPT12028"/>
        <property type="gene ID" value="CYQ11_03155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="28802" checksum="07004C78E5FFE27B" modified="2018-01-31" version="1">MTTFVAQRNGRAATAEELAPLAFAGYAHFTAMQVRDGRVRGLDLHLERLRFASLEMFGRAVPDERVRAHLRTALEAGPGDVSLTATMYAPAHESVAAGAAVEPDVLVRTRPAASAPECPLALAAVEYERFLPAVKHVGEVAKVYTPRQAVGQGFDDAAFVDRRGRLSEASIWNLAFWDGEAVVWPEAEMLTGTMMGVVRRQLDRLGVPQRLQEVTLADLPALSGGVVMNSWSPGVAVKRIGSVALPQAPAFLELLHRAYEAEPPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNK7</accession>
    <name>A0A2G1XNK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05805</name>
        <name evidence="3" type="ORF">CYQ11_02280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52827">
        <property type="protein sequence ID" value="PHQ52827"/>
        <property type="gene ID" value="BLA24_05805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16302">
        <property type="protein sequence ID" value="PPT16302"/>
        <property type="gene ID" value="CYQ11_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="158" mass="16528" checksum="55A901F46E503828" modified="2018-01-31" version="1">MCAAWAVSVWISVHLQADATLHTAALFIHLASLVLGFGAVLVADYYGLLWITGRCTLREALDAAGRLHLPIWVGLAGLVASGMMLHPNPSATLTSVKLVMVLALSLNGLQAGMLNKRMASQTSGAPTTGLLAWGGATALVSQVGWWVAVVVGFLNSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN1</accession>
    <name>A0A2G1XNN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04540</name>
        <name evidence="2" type="ORF">CYQ11_28985</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52847">
        <property type="protein sequence ID" value="PHQ52847"/>
        <property type="gene ID" value="BLA24_04540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11496">
        <property type="protein sequence ID" value="PPT11496"/>
        <property type="gene ID" value="CYQ11_28985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="435" mass="45694" checksum="AE77D99F7CE661E4" modified="2018-01-31" version="1">MQSSSITSSYLAGYRRVTGGTRGAAEAEGPGGSGALLPVTGAQRRFLLARRLDPAGRPALVPLFFTFPAGAVDPDRLRAAALHLAALHPALRTRPLVRRGVPLQRVTEPEAHVGRVRPRPGERAEGALLRALARWPAEGPPLRLFLAGDGDGEEILAVVLDHVACDEQSLGRVLADLGDAYRDRLGPHDVPADRAEAGLASYRDAVLLQLDAEDGGSGPRALAHWTRRLAGLRPPGPVPHEGTSAGTGTARRRLPLGVAGGRAAAFPAVLHACARAARTLHGPDRVAALGYPWGGRPAAAAPVLGCFLNTVVHPADDVGPGERAVAWWDDLDHADAPFDSVVHAARGAGVPWSGRLDGLLTFEDLGRRPPLRLGDATGRETHLDDRPLPAPFAVSVSYGTDVLVRMAWDRAAVPDGLARDAFETLLDTLSAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNQ3</accession>
    <name>A0A2G1XNQ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04795</name>
        <name evidence="3" type="ORF">CYQ11_28735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52885">
        <property type="protein sequence ID" value="PHQ52885"/>
        <property type="gene ID" value="BLA24_04795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11456">
        <property type="protein sequence ID" value="PPT11456"/>
        <property type="gene ID" value="CYQ11_28735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="17110" checksum="4F48B018D63D4125" modified="2018-01-31" version="1">MTQIEESIEVAVPVTTAYNQWTQFEDFPQFMEGVERIEQRGPTLTHWVTKTGGVRREFDAVITEQIPDERVAWTTVAGEVRQAGVVTFHRLTPERTKVMVQFDHDPDGVVDTVGDKLGFVRRQTKGDLERFKSFIESRGLETGQWRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNV5</accession>
    <name>A0A2G1XNV5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05130</name>
        <name evidence="3" type="ORF">CYQ11_28400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52935">
        <property type="protein sequence ID" value="PHQ52935"/>
        <property type="gene ID" value="BLA24_05130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11404">
        <property type="protein sequence ID" value="PPT11404"/>
        <property type="gene ID" value="CYQ11_28400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="13389" checksum="3BA198C6A85C6315" modified="2018-01-31" version="1">MFKDTKAFSGFSVNDVGEAKRFYGETLGLTVSEDHGLLHLHLAGGTPVLVYPKENHTPASFTVLNFPVDDIEAAVEELGRRGVRFERYPGLEPDEKGIFRGGGPLIAWFTDPAGNVLSVLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP74</accession>
    <name>A0A2G1XP74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_05280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52959">
        <property type="protein sequence ID" value="PHQ52959"/>
        <property type="gene ID" value="BLA24_05280"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="787"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1855"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="822"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="1952" mass="206146" checksum="ECCCB935B8D4E272" modified="2018-01-31" version="1">MVFAGRVDDQVKIRGFRVEPGEIESVIAAHPRVAQAAVTVREDTPGDKRLAAYLVPADHGTDDLADVVRRYVADRLPSYMMPAAITLLDALPLTANSKLDRAALPAPDSAATAPGTTGRAPANAQEELLCEAFAEVLGLPVVGVDDDFFSLGGHSLLAVSLVEWLRARGVSVSVRALFATPTPAGLAAVAGPGQVVVPPNRIPIGTSEVTPEMLPLVDLTEAELATVTVSVPGGAANVADVYPLAPLQEGIFFHHLMADQDSGDVYVLPFVLAFDTRERLDGFLTALQWVVDRHDIYRTAIVWEGLREPVQVVARHVDLPVTEVALDSADDAAGQLMSRAGSWMALDRAPLLTAHTAAEPGTGRWLALVRIHHLVQDHTALDVLLGELRAFLAGDSDELPAPLPFREFVAQARFGTTEQEHERYFAALLGDVTGTTAPYGLLDVHGAGSAVARDRLDVDEALAGRVREVARSLGVSPATVFHLAWARVLAAVSERDDVVFGTVLFGRMNAGAGADRVPGLFINTLPVRVPVKGRSVGEALAGMRGQLADLLVHEHAPLAAAQRAAGIPGNGALFTSLLNYRHSRPSSQQAGSAIEGVATLFDREGNNFPLTVSVDDDGAGFALTVDAVAPVDAGQVCGLVHTALANLVTALAEAPDTRLAAVDVLDAPLRRRLTDGAAPVGGPATAAPRAYVLDGFLSPVPYGAVGELYVAEPAPGPDARPGPAGQDEPAEADLVACPFGPAGRRMHRTGERARWTPDGVLERLGAPGEAAPEGRPDGADATAADRAPADDLESLLCAEFAHMLGRDSVGVHDNYFLLGGHSLLATRLISRLRSVLGAEVPLRALFEHPTPAGLAGHLARTGLVRTAPRRAPLRAGKRPERLPLSFAQQRLWFMGQLDGSSATYTNTTALRLTGPLNREALAAAVRDVVGRHEVLRTVLPLSDGTGHEPGTGHDGEPFQLILPADETDVAMPVIEIAPADLAGQTARTTGHTFDLATEIPIRTWLFALAPDHHVFVLAVHHGATDGWSTGVLARDLSVAYTARLDGHAPQWPPLPVQYADYALWQRDLLGDPRDPDSVLSQQLAYWQDALAGAPEEIALPADRPRPSVATHRGDEVAVDIGADLHRRIVALAQAENVTVFMVMQAALAALLSKLGAGDDIPIGSPLAGRMDDALDDLVGFFVNMLVLRTDLSGDPGFRELLRRVRGTDLAAFAHQDVPFEHVVETLAPERSVARHPLFQVTLAVQNTPDSALRLPGLAVRAEPLEEGTTRYDLTLNLAESTDADGAPAGMGGVLQFATDLFDRPTVQALADRLLHLLESVVADPERPLSRVDAMTPQERRTVLDWSTGPERTIEATTLPELFADQVRRSPSAVAVRSGDTVLTYSQLDARADRLAQRLARRGAGPEKLVAVVLPQSVELAVTLLAVTKTGAAFLPVDPAYPADRVRFVFDDARPVLVVVSGDTAERAPVDPELLFLLDDQETDDGAQCTLTPPSPANAAYVIYTSGSTGRPKGVVVSHGGVPGLAVAQGDAFGVGVGCRVVLLASPGFDASVMELVMALGSGAVLVVPEGGGGLAGEELAGVLVGEGVTHGLIPPSVLATVPVPVGDVLETLVVGAEVCSAGLASRWSVGRRLVNAYGPTEVTVLCTLSDAVVGGEVPPIGRPIVNTRVYVLDDTLRPVPPGVVGEVYVAGPGVARGYLGRPAHTAQRFVADPLAGPAGGRMYRTGDRARWRADGQLDFAGRADDQVKIRGFRIEPGEVEAVLAAHPGVAQAAVLVREDVPGDKRLVAYLVPSRQDPDDLVDTVRAHTAERLPRYMLPAAFTVLDTLPLTVNGKLDHRALPAPDYGAAATSTGRAPATPEEELVCGVYADTLGLPKVGADDDFFALGGHSLLATRLLSRLRALAGIDVSLRVLFENPTCSALAAWIAAQAGGRKTTKRNRPTLRPMRNQEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP87</accession>
    <name>A0A2G1XP87_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0060 membrane protein BLA24_04245</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_04245</name>
        <name evidence="6" type="ORF">BLA24_14055</name>
        <name evidence="8" type="ORF">CYQ11_14015</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0060 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50924">
        <property type="protein sequence ID" value="PHQ50924"/>
        <property type="gene ID" value="BLA24_14055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53036">
        <property type="protein sequence ID" value="PHQ53036"/>
        <property type="gene ID" value="BLA24_04245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13857">
        <property type="protein sequence ID" value="PPT13857"/>
        <property type="gene ID" value="CYQ11_14015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="111" mass="11688" checksum="10325F97ED2E2E1A" modified="2018-01-31" version="1">MLIVRSTALFVLAALLEIGGAWLVWQGVREHRGWAWVGAGVIALGAYGFVATLQPDAHFGRILAAYGGVFVAGSLAWGVVADGYRPDRYDVAGALVCLAGVAVIMYAPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP93</accession>
    <name>A0A2G1XP93_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BLA24_04950</name>
        <name evidence="17" type="ORF">CYQ11_28580</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52979">
        <property type="protein sequence ID" value="PHQ52979"/>
        <property type="gene ID" value="BLA24_04950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11508">
        <property type="protein sequence ID" value="PPT11508"/>
        <property type="gene ID" value="CYQ11_28580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="14">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="217"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" description="distal binding residue" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ52979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="448" mass="49628" checksum="9A044912C2A33419" modified="2018-01-31" version="1">MGRSAPRPRAERARSGGAILLALCARHEERRHVNTTRGNDYYALLARHDAMRLRRQMLSPGAVAAPDRTTAGGAHRPPCDEADRRLILGGLHLVTPFDDLITHLYEVMFGRWPYLRSLFPDSMTFQRQHLAQVFGYLTDRLDRPDEVAATFTRLGRDHRKLGVRPAHYEAFEAALCEALRARAGARWTTELEGAWLRMLRFAVGAMVAGADAAITEPPAWHATVVGHELRRPDLAVLRVRTHERYPYRAGQYGALEAPSLPHAWRQYSMACAPRADDEIEFHVRRTGAGGVSEALVSRTRVGDTLRLGPAAGTMTLDGHLTHDLLLVAGGTGLAPFKALVDELGTRPPGDRRVHLFVGARHHADLYDRDWLADVERRRPWLRVLPVFGGTPATLAAVRRHGERLGLDWSGRAAAVSGPPEMVRATVAELRDLGLPADRIRHDPLPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPB1</accession>
    <name>A0A2G1XPB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_04020</name>
        <name evidence="9" type="ORF">CYQ11_07295</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53053">
        <property type="protein sequence ID" value="PHQ53053"/>
        <property type="gene ID" value="BLA24_04020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12717">
        <property type="protein sequence ID" value="PPT12717"/>
        <property type="gene ID" value="CYQ11_07295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="622" mass="65348" checksum="BE333C5A7F93BC54" modified="2018-01-31" version="1">MGLRHAHRRPPRPPPGTARRTRRGSGVRDMTTHPATLSPTTATALTTCGAALTAFSTYLPWTWTTAFPGNLTITGYPGGLQLFTLIGAALTLIQLLAGHGIPGLRWLNPARTHTPALLLATGTLATTWYTLIAIAVQLGGLVNLEPGGAVAAIAPLITLTGTLALAHHHATEDHTHQDRTTTATAALLRTARTLLNGPGSHTPPPPRPLPAPAGIAIIAAVFALALYVLTYGIGTAYGELFTGFLLLAAFTTAALFKAGLITRLRHLTHQHRHVTITAAFLTAALFPLTQDTDEYTLIIVNILIFATVALGLNVVVGLAGLLDLGYVAFLGVGAYTAALVSGSTASTLHVHFPFWAAALTGAAASLIFGIVIGAPTLRLRGDYLAIVTLGFGEIFRIAVGNLNGESGPSLTNGPNGIPNIPDLALGSYHFGDTHSLAGITLTPFANYYFLMLLITVIVVLVFSRAGNSRIGRAWIAIREDETAATAMGINSFRLKLLAFALGATLAGLAGTVQAHVAQTVVPEQYVFAGPVPPNSAFLLAAVILGGMGTISGPLLGAALLYLIPAKLQFLQDYQLLAFGIALILLMRFRPEGLIPSRRQQLEFHDTTDNRPDDGVQLTKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPN5</accession>
    <name>A0A2G1XPN5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02235</name>
        <name evidence="4" type="ORF">CYQ11_04595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53180">
        <property type="protein sequence ID" value="PHQ53180"/>
        <property type="gene ID" value="BLA24_02235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12272">
        <property type="protein sequence ID" value="PPT12272"/>
        <property type="gene ID" value="CYQ11_04595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="450" mass="49709" checksum="640D9E00481B81A3" modified="2018-01-31" version="1">MDRGAVPRPRTKSRELTPAAVRLPWGPRRCEEIPTVPLPDPVPLYGPEYKRDPYPLYARMRDAGPVHRVLFPSGVTAWLVTGHAAAQRTLADPRLGKNHALGNDRWRERASIMPEPQHSQLQVHLLHQDAPKHTAMRRLVTDAFAPRRVEELRPRFQRMADALVDAMPAGADSADLVRCFAARFPFQVLAEVIGLPPHLAARFRREWGKVVAPVGPTDPGRPAYEALLRELQEYIAEVVADRREHPGDGLLGRLVAARDEGELTPEELDSMIFQLLVAGQEPVTNQITTALVALTRHPRALERLRAEPELMPAAVEELMRLDSAFELTTWRFLAEDADLHGVRVPAGDSVIVSLCAANRDPERFPAPDTLDLDRSQGPHLAFGHGVHFCPGAALARIELQVALGTLIGRLPGLRLAVPDEDLPWIPAVLGRGVAELPVAFDPPVCPRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPR0</accession>
    <name>A0A2G1XPR0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-binding alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02605</name>
        <name evidence="3" type="ORF">CYQ11_04900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XPR0"/>
    <dbReference type="EnsemblBacteria" id="PHQ53224">
        <property type="protein sequence ID" value="PHQ53224"/>
        <property type="gene ID" value="BLA24_02605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12316">
        <property type="protein sequence ID" value="PPT12316"/>
        <property type="gene ID" value="CYQ11_04900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="317" mass="33271" checksum="01D0160B086D808C" modified="2018-01-31" version="1">MHAAVVRTIGQPPVYGEFPDPTPQEGEVLINVRAAALTNLGKLVTYDPDYSAGAEVPFVAGVEGVGTLQDGTRVGFAAQRPPYGSMGELTVSFAPLAFPVPDGVSDATAAALINPGFSSWLPFASQLKLEAGAKVLILGATGVAGKLAVQIAKHLGAGRVVAAGRNRAALEQLPSLGADRVVSLDQPEEKIAAEFAQEAGEHGFDVVLDYIWGRPAEIFLGSLPRSLEAEGEVRYVQLGNSAGPTATIEGNALRRAGITIIGTGSMPSLDIVKDVWERMTDAVVKGSLTIDVDEVPLSEVHDAWNRETPGRRLVFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPR2</accession>
    <name>A0A2G1XPR2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_02625</name>
        <name evidence="5" type="ORF">CYQ11_04920</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53228">
        <property type="protein sequence ID" value="PHQ53228"/>
        <property type="gene ID" value="BLA24_02625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12320">
        <property type="protein sequence ID" value="PPT12320"/>
        <property type="gene ID" value="CYQ11_04920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="24267" checksum="7B3BFFA0E2DC2DFD" modified="2018-01-31" version="1">MADQIQSSHALLEYVRDVSLRDDPVLRGLRKETAELPMGTAMQVMAEEGQLLALLVTLCGATRVVEIGTFTGYSALCMARALPPHGRLVTCDITDRWAATAAPYWREAGVFDRIELRVGDACATLEQLLTEWGPDSVDLVFVDADKANYPRYYEAALSLTRPGGLVVVDNTLFFGRVIDPGAQDRDTLAVRELNRLLHGDERVDMSLLTMADGITLARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ76</accession>
    <name>A0A2G1XQ76_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000027">
        <property type="protein sequence ID" value="PHQ53373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53373">
        <property type="protein sequence ID" value="PHQ53373"/>
        <property type="gene ID" value="BLA24_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="167" mass="19033" checksum="AF1F829497BD7AC4" modified="2018-01-31" version="1">MDRASPTRRPPMSQPAYPPTHWIPANSANYTPSARPEAHPVGFLVIHVTEETFQDARRIFQDPTSKVSAHYMVASKDGYIGQFVREKDIAWHAGNWDYNTRSVGIEHEGWTDRPEYFTDALYRSSARLARAVCDRYGIPPTRAHIIGHNEVPGATHTDPGPHWDWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQI0</accession>
    <name>A0A2G1XQI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00625</name>
        <name evidence="4" type="ORF">CYQ11_07635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53470">
        <property type="protein sequence ID" value="PHQ53470"/>
        <property type="gene ID" value="BLA24_00625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12775">
        <property type="protein sequence ID" value="PPT12775"/>
        <property type="gene ID" value="CYQ11_07635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="245" mass="26163" checksum="9F06196BE10FBF25" modified="2018-01-31" version="1">MTTARLPLFPLNSVLFPGLVLPLNVFEQRYRAMMRDLSRLPEDAPRRFGVVAIRDGHEVAPSAPGLPDETRPEPGPAAGFGTDPAKAFHGVGCVADAASIRERPNGTFEVLATGTTRFRLRSVDASGPYLVGEVEHVEERQGDEAGALASGVVRAFRAYQKRLAGAGEASLAGQSELPGEPQVLSYLVAAAAVLDTPAKQRLLQAPDTASRLADELRILRAETAVIRQLPSLPAVDLTRRPTSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ4</accession>
    <name>A0A2G1XQJ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00820</name>
        <name evidence="3" type="ORF">CYQ11_07830</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53506">
        <property type="protein sequence ID" value="PHQ53506"/>
        <property type="gene ID" value="BLA24_00820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12811">
        <property type="protein sequence ID" value="PPT12811"/>
        <property type="gene ID" value="CYQ11_07830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="709" mass="74045" checksum="C3F15338E7160ACB" modified="2018-01-31" version="1">MRSPKLAALELRRFGRGRLPRAALVALLLLPLLYGALYLWSFWDPYGRLDKVPVALVNADRGTEVDGQRLDAGASIAEGLRGSKSFAWHETSADDAREGVEKGKYYLSLTIPPDFSDKVASSSGASPVAGALQVRTNDANNYIVGQISRTVFSEIRATASRKASRSFYDRIFVSFSGLHDKTQKAAEGADRLGEGIGEARKGAGDLKDGLARAERGSGDLESGVAQLHTGAGTLDSASGELASGAQKVASGTQRLADKVNGVAGKEGAFVKEHAREIGATARDVAKEAQTVREHLDDLPSPATTALLASGSRRGAEDLAAAYAKACPPAGAPGFCPTLKKAVFAAQQSAAGAEKLNTLMQNKNGELDRLPGRLDTLRGYALRLAAEAPHLGRDIDGAVRDVNALNDGAQKLAEGAGKLHTGAGRLHTGLGTAKEGAADLDGGIGKLREGAGTLQGGMFKLSDGSAELAGGLHDGAGRIPDYDKKDRDARTEVMADPVGLASRALHKAPNYGTGFAPYFIPLSLWVGAMVAYMLIQPLNRRALAAGAPAWRIAVAGWLPVVAVGVLQTGALLAVLHWGLGLHMARTAGTAGFLCLVTACFAAIVQWLGARFGPAGRILVLALLMLQLTSAGGTYPVQTSPGFFNAVHPFLPMSYVVDGLRHLITGGGLGPVWQACGVLVAFTAGALALTAWSARRAQVWSVDRLHPELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQL2</accession>
    <name>A0A2G1XQL2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00920</name>
        <name evidence="6" type="ORF">CYQ11_07930</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53524">
        <property type="protein sequence ID" value="PHQ53524"/>
        <property type="gene ID" value="BLA24_00920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12829">
        <property type="protein sequence ID" value="PPT12829"/>
        <property type="gene ID" value="CYQ11_07930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="23510" checksum="35E255FBAB8D032F" modified="2018-01-31" version="1">MTADAVRVMVVDDHPMWRDAVARDLAAAGYDVVATAGDGPQAVRRARAVVPDVLVLDLNLPGLPGVAVCKELVAEQPALRVLVLSASGEHADVLEAVKSGATGYLLKSAGPEELLDAVRRTAAGDPVFTPGLAGLVLGEYRRLAADPAPAADEPKAPALTDRETEVLRLVAKGLSYKQIAERLVISHRTVQNHVQNTLGKLQLHNRVELVRYAIERGLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X999</accession>
    <name>A0A2G1X999_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30275</name>
        <name evidence="4" type="ORF">CYQ11_23370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47801">
        <property type="protein sequence ID" value="PHQ47801"/>
        <property type="gene ID" value="BLA24_30275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15426">
        <property type="protein sequence ID" value="PPT15426"/>
        <property type="gene ID" value="CYQ11_23370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="183" mass="19741" checksum="8E92B1FEC1F940A5" modified="2018-01-31" version="1">MSFRVRTSTSSCQASLAPQSAPSEAELLAFVRRTAADAELVAALPLDPEGRTWIRLEGPGGSEAWLIGWPPGAGTGWHDHGGSHGAFAAAAGGLTEQSLAAQLPTEGWKVLELADGVDRERRLTGGDGRAFGPHHVHQVFNTSPTEHAVSVHAYYPPLPMMRRYGRTGQVLRLEQVEWPEEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9I3</accession>
    <name>A0A2G1X9I3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30760</name>
        <name evidence="3" type="ORF">CYQ11_23855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47890">
        <property type="protein sequence ID" value="PHQ47890"/>
        <property type="gene ID" value="BLA24_30760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15515">
        <property type="protein sequence ID" value="PPT15515"/>
        <property type="gene ID" value="CYQ11_23855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="15880" checksum="7A252337AF352F75" modified="2018-01-31" version="1">MNDHMNKELGWMLDEVVKMPEARHAILLSADGMLRAHSQGIDRDEAERQAAALSGLQSISRSTAEFCTHPHHQDSPWRQTLIEFAHGYVFLIAAGPGAYLAVSAGEDVDMEAVTYRMQKTVDRLGKELVSPPRQDAWQGPGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9J9</accession>
    <name>A0A2G1X9J9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR02678 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30870</name>
        <name evidence="3" type="ORF">CYQ11_23970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47907">
        <property type="protein sequence ID" value="PHQ47907"/>
        <property type="gene ID" value="BLA24_30870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15532">
        <property type="protein sequence ID" value="PPT15532"/>
        <property type="gene ID" value="CYQ11_23970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013494">
        <property type="entry name" value="CHP02678"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09661">
        <property type="entry name" value="DUF2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02678">
        <property type="entry name" value="TIGR02678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="418" mass="45807" checksum="863B0DBD18C74FF8" modified="2018-01-31" version="1">MTTPLGDVLDGRRTAETHKAARALLKEPLLLAQGPYADEFRLVRQHASVLREWFDRNTGWSLRLDAEGARLARTPGSLADPTHPAREASRARAPFTRRRYVLLCLALAALERGEAQIALGRLADQVTLDAADPHLVAAGVEFTMERRDERLDLAAAVRLLLRYGVLRRVAGDEEAYVTGTGDVLYDVQRRVLAGLLSARRGPSTITCGDFEERLAELTAESALDSDDLRFRAIRQTLTRRLLDDPVLYYDELSDEELAYLTRQRAFITARITELTGLVPEVRAEGIAMVDPQDDLTDVRMPEQGTHGQITLLLAEYLAASDGEVSRGDLERRVRELAAEHGAFWSKSAKQPGAEAELVGQALERLTALGLISHTAGGVTALPALARYAVGEAVVTEPGRTAPRSSRTSPTSQRKASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9K4</accession>
    <name>A0A2G1X9K4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02679 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30860</name>
        <name evidence="4" type="ORF">CYQ11_23960</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47905">
        <property type="protein sequence ID" value="PHQ47905"/>
        <property type="gene ID" value="BLA24_30860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15530">
        <property type="protein sequence ID" value="PPT15530"/>
        <property type="gene ID" value="CYQ11_23960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013495">
        <property type="entry name" value="CHP02679"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024466">
        <property type="entry name" value="CHP02679_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024465">
        <property type="entry name" value="DUF2399"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09664">
        <property type="entry name" value="DUF2399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11796">
        <property type="entry name" value="DUF3323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02679">
        <property type="entry name" value="TIGR02679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3323" evidence="2">
        <location>
            <begin position="43"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2399" evidence="1">
        <location>
            <begin position="264"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="415" mass="43775" checksum="F3092E93E6826B36" modified="2018-01-31" version="1">MSTPHASATRIDHDRLTRLLGDPDCAWLVDRARSRMERGEPLAGPVTLAAPTAGERAAAERLLGRAPGSGRSLSVRLDTVDAVLRRSGVSPEGLGAAVVALTGPVVLLSDVLKQEANAWQGACAPLTTLGTERPELAGWSEQTIRNGLVRRLARTPDAAHTLLTATTTALRQLPAEPPVSLPAFAARTLGDAHALDDGTPLATLVLSGIRALTGFPDGTGAEWRREAWASAGLLKDALSSTVLTLGLRGTPALDWAADAGEPAVLTLRQLTRTPPLTAPLVVYVCENPTVLATAADTHGPACPPLVCLQGQPSAAALTLLRHLHTRGSQLRYHGDFDWGGIRIATALLQRVPWRPWRYTAAEYRTAATAAPLAPPLTGKPVDAPWDPELRPALTGLGVRVEEETVLDDLLADLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA20</accession>
    <name>A0A2G1XA20_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="6">HIU hydrolase</shortName>
            <shortName evidence="6">HIUHase</shortName>
            <ecNumber evidence="6">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uraH</name>
        <name evidence="8" type="ORF">BLA24_32090</name>
        <name evidence="9" type="ORF">CYQ11_25150</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48084">
        <property type="protein sequence ID" value="PHQ48084"/>
        <property type="gene ID" value="BLA24_32090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15710">
        <property type="protein sequence ID" value="PPT15710"/>
        <property type="gene ID" value="CYQ11_25150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="7">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="12544" checksum="DD620CCB4666C511" modified="2018-01-31" version="1">MSTEPAVAAGAASVSTHLLDTAAGRPAAGVAVELSAAADDGEWTVLGAARTDADGRCTGLPALPGRAARARLRFDVEPYLSRRPQGAAFFPEVTVTFAVAAGEHHHVPLLLSPFGYSVYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA31</accession>
    <name>A0A2G1XA31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32225</name>
        <name evidence="2" type="ORF">CYQ11_25280</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48107">
        <property type="protein sequence ID" value="PHQ48107"/>
        <property type="gene ID" value="BLA24_32225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15733">
        <property type="protein sequence ID" value="PPT15733"/>
        <property type="gene ID" value="CYQ11_25280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="124" mass="13394" checksum="932CE2B338AA7016" modified="2018-01-31" version="1">MSNPDDLLVGISTMVESGQSNQMSLTVVVGGAVITGRLAPEAAWRERVSEVLKDSDHLGSFSAVFSADRPQDRADRAEAPTHLHFHLARILQGNIGIPETGGMYRVAIKDVSAWTVGDFSYSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA96</accession>
    <name>A0A2G1XA96_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">alc</name>
        <name evidence="5" type="ORF">BLA24_32115</name>
        <name evidence="6" type="ORF">CYQ11_25175</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48089">
        <property type="protein sequence ID" value="PHQ48089"/>
        <property type="gene ID" value="BLA24_32115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15715">
        <property type="protein sequence ID" value="PPT15715"/>
        <property type="gene ID" value="CYQ11_25175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="4">
        <location>
            <begin position="229"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="379" mass="40531" checksum="CB962C05D3CF6AA7" modified="2018-01-31" version="1">MTTSGISGGTSFTGPAGPYPGGDPYADYRAAAFAFEAWPDLADRRLGAGVIAASDEFFAERENLLTPEAPVFDPAAYGPKGKVMDGWESRRRRGAHAGRPHPDDGEHDWALIRLGVPGAVRGVVVDTAHFRGNHPESVAVEGAALPGTPSPGELLADDVRWTPLVPRTPVGGHAANGFPVDTARRFTHLRLSQFPDGGIARLRVHGEPLPDPAWLAALGTFDLAALEHGGRVEDASDRFFSPPFHSILPGRSRKMSEGWETRRRRDKGHDWVRYRLAGHCVPRAVEIDTGCYVGNAAGWAALSVLDATTGADPVDPTAGWTEVLAPTRLQPDAVHRLALTGVPAATHLRVDIYPDGGIARLRVHGSLTEAGVRGLRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAA2</accession>
    <name>A0A2G1XAA2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32565</name>
        <name evidence="3" type="ORF">CYQ11_25615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48160">
        <property type="protein sequence ID" value="PHQ48160"/>
        <property type="gene ID" value="BLA24_32565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15786">
        <property type="protein sequence ID" value="PPT15786"/>
        <property type="gene ID" value="CYQ11_25615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="19141" checksum="EA2E40B7E2B16E8D" modified="2018-01-31" version="1">MVRIREMTEADADAVAEIRVRGWRTAYAGLLPGGHLDALDAAEDAARRRERLAAGDARVADLVAESAEGDVVGWVCFGPCRDADQQADTAELYALYLRPERIGTGVGRSLCAAAVEGTRKRGYARMSLWVVRDNARARRFYERAGFAPDGAEDVYDADGTPVPEVRYVLDPLRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC0</accession>
    <name>A0A2G1XAC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32700</name>
        <name evidence="7" type="ORF">CYQ11_25750</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48184">
        <property type="protein sequence ID" value="PHQ48184"/>
        <property type="gene ID" value="BLA24_32700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15810">
        <property type="protein sequence ID" value="PPT15810"/>
        <property type="gene ID" value="CYQ11_25750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CHAT" evidence="5">
        <location>
            <begin position="106"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="437"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="687" mass="73741" checksum="3D691B038B4B0004" modified="2018-01-31" version="1">MPTDSTDFVVEIGRGGDTAGRYVVGVSSPAGEETLHVCLDPHAVGARLEDIQSAVLASSVARRAAALGLEQPVREVGVELFGAVFGGHVRSLFLSSRQRAEERDEALRVVLRIRAPELAALPWELLHDADLGGYLCLRDPVVRHVDVPELVLPLRGDPPLRILGMTALPGSRAPLDADSERTGLTLALRPLVDRGLVRLDWVTGQTAEDLRRRLLDGCHVLHFIGHGAYDPARQEGMIALADEQGREHLLHATALAALVSVAKPRPQMVVLNSCQGGMGNSEDLFSSTASVLVRTVPAVVAMQFAVTDKAAARFAASFYQAVAFNRSVDEAVRIGRVALVVDKDDSLEWATPVLYLRGRNARLFDLGVTEDDGGPEPEPSPPPVPPAARITSRVLPAGQWVHAVAFHPDGRRLATGSRRRIRVWDTETGNRVWEQPVGGWLSSVFACAFSPDGQRLATGGADGTARMWAASGDQLLTLRHDHVVTAVAFGPDGRHLATASADRSARLWDTVSGEPLLRVRHDQVVSDVAFDPDGQRLATASGDRSARLWTLSGEPLLRLRHDHGVKTVAFSPTGHQLATGGDDGSVRLWNTHTGHQVLLVRHAGAVKDLAYSPDGHRLATAGADHSAIVWHTADGNRLLRVQHGHTVFAVAFSPDGRWLATGSEDKTVKLTPLPPTAPPRVGDLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAE0</accession>
    <name>A0A2G1XAE0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32690</name>
        <name evidence="3" type="ORF">CYQ11_25740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48182">
        <property type="protein sequence ID" value="PHQ48182"/>
        <property type="gene ID" value="BLA24_32690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15808">
        <property type="protein sequence ID" value="PPT15808"/>
        <property type="gene ID" value="CYQ11_25740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="19767" checksum="F2950A269F24F5CD" modified="2018-01-31" version="1">MALSLRTPRLTLRRWREDDIVPMAAINSDPEVMRWIGDGSVRDRSQTEAGIVAWEREWEERGVGLFAVEERTSRQLVGFAGLSEPVFLPEILPAMEIGWRFGRPYWGRGLATEAARAALDFALRDRGLGRVVSVCAPGNVASERIMRKLGMRRERETAHPLHGVPLRVHVIEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAM7</accession>
    <name>A0A2G1XAM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33195</name>
        <name evidence="3" type="ORF">CYQ11_26245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48265">
        <property type="protein sequence ID" value="PHQ48265"/>
        <property type="gene ID" value="BLA24_33195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15895">
        <property type="protein sequence ID" value="PPT15895"/>
        <property type="gene ID" value="CYQ11_26245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="94" mass="9870" checksum="37A11A3F4BF8D9A0" modified="2018-01-31" version="1">MWPALGCLAVAGAADTVSVSPAVPWSDRRPGRFFSLVFGGLFAILAVATVSAANAPFASTAHRLLPRSRARRIPLRHLSYLPSFACAYSVGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAV8</accession>
    <name>A0A2G1XAV8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pssA</name>
        <name evidence="9" type="ORF">BLA24_32515</name>
        <name evidence="10" type="ORF">CYQ11_25565</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48374">
        <property type="protein sequence ID" value="PHQ48374"/>
        <property type="gene ID" value="BLA24_32515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16800">
        <property type="protein sequence ID" value="PPT16800"/>
        <property type="gene ID" value="CYQ11_25565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="281" mass="29924" checksum="635A7B9E5DD97D51" modified="2018-01-31" version="1">MIDPDTQAAWVPEADDDAADDMPLSTRLSIADTLTLGNAICGFMAVYFTTTGVLIPHLTGNEDGGMARHSAATAVILMLLASVFDLFDGLVARKLRSSAMGAELDNLSDLISFGLAPAYFVVVWGMVADDAHQRVSAVAAIVVLLAVVLRLARFSCVPMRDGIFQGMPSPFGALTVVSIVLLELPFVPTLLAIMGVAWLMVSRVEYPKPRGPLAVAMLSWIVLSMGLLAAWAFDAPGGELLLQTGCALQVVLGAVIPLFATARRVNTFRDNRREARAAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB35</accession>
    <name>A0A2G1XB35_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Decarboxylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Type III PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29235</name>
        <name evidence="5" type="ORF">CYQ11_06240</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48454">
        <property type="protein sequence ID" value="PHQ48454"/>
        <property type="gene ID" value="BLA24_29235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12550">
        <property type="protein sequence ID" value="PPT12550"/>
        <property type="gene ID" value="CYQ11_06240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="274"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="41319" checksum="1DEB4A4949C6FC3D" modified="2018-01-31" version="1">MITPPVAALAARLPAGRLPAYVHDLAALDGHAAAVRAALPRAVELYYAVKANPAAEILAALAPHVSGFEVSSGGELAHVRASVPGLPLAFGGPGKTEEELLLALDAGVRRFHVESERELRLLAALADGRPGGAPVDVLLRVNLPAAPGDPGGAALTMGGGPSPFGLDPRAAAACVPLLRGRLRLRGVHAHLASGLDAPSQLAVAAAVAGWAREFGDRHGLAVPEVCVGGGMAVDYTRPRSRFDWTAYGQGLAALAAEHPGVTFRVEPGRSLTAYCGWYVTEVVDLKHSHGEAFAVLRGGTHHLRTPVAKGHDQPFTVLPVDVWEHPWPRPAALDEPVTLTGQLCTPKDVLARRVPVAELRAGDRVAFAMAGAYAWNISHHAFLMHPAPEFHFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB71</accession>
    <name>A0A2G1XB71_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF952 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29055</name>
        <name evidence="2" type="ORF">CYQ11_06420</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48429">
        <property type="protein sequence ID" value="PHQ48429"/>
        <property type="gene ID" value="BLA24_29055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12575">
        <property type="protein sequence ID" value="PPT12575"/>
        <property type="gene ID" value="CYQ11_06420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="13117" checksum="14AF2DA0F1A2644B" modified="2018-01-31" version="1">MIFHVVPLDDWLAVPDRPYSPASLADDGFVHCSPDEATTLAVATAYYREVPGPLMALLIDEHKLDVMVRWEAADPAPPPGAAPGALFPHVYGRITRDAVEGMMEIQRDEDGRATGMTVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB81</accession>
    <name>A0A2G1XB81_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29450</name>
        <name evidence="3" type="ORF">CYQ11_06025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48488">
        <property type="protein sequence ID" value="PHQ48488"/>
        <property type="gene ID" value="BLA24_29450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12513">
        <property type="protein sequence ID" value="PPT12513"/>
        <property type="gene ID" value="CYQ11_06025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="31190" checksum="3C3EFFDA720C3CB3" modified="2018-01-31" version="1">MTFDPEQLGQPKQELAALLKELRKRAGLTGDRLARRCNMSQSKISRIENGKAQPSLLDLERILRAVVAPPEVIEEVIALARLANTEWQDLRSLRRRGLEKKQTELAALESSSTQFRFFLLSMITGLLSTPEYIRASLAHSPADVTKTIARKLERQEVLYDTKKRFTFILTEQAVRWPLLPPAAMAMQIDRLVSLTHLTNVKLGVIPIAGYKPMAPMDTFTVYENTLATVENATGVVILRDPRDIEMHLELFSTLEGYALFGDEVRALLAEWSAACRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBR6</accession>
    <name>A0A2G1XBR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3099 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28735</name>
        <name evidence="4" type="ORF">CYQ11_06730</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48694">
        <property type="protein sequence ID" value="PHQ48694"/>
        <property type="gene ID" value="BLA24_28735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12625">
        <property type="protein sequence ID" value="PPT12625"/>
        <property type="gene ID" value="CYQ11_06730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="128" mass="13475" checksum="D525620A6A5D95FB" modified="2018-01-31" version="1">MRKLGGTEVFRITGARQGLEEDVRGRQRRYVISMGVRTLSVVLTVILWNIERYVAVGTLVLGALLPYVAVVIANAGRENAPSLPGTFVPAPTRPVLTAGPAGGVAEPVPEAAPDAEGPARPDQGPDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBW2</accession>
    <name>A0A2G1XBW2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_28895</name>
        <name evidence="8" type="ORF">CYQ11_06570</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48723">
        <property type="protein sequence ID" value="PHQ48723"/>
        <property type="gene ID" value="BLA24_28895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12597">
        <property type="protein sequence ID" value="PPT12597"/>
        <property type="gene ID" value="CYQ11_06570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23449" checksum="3118F9F9DBE73ABB" modified="2018-01-31" version="1">MIAAPDRMPLAREFFDRPVLEVAPELLGRTLVRTSPEGVIELRITEVEAYAGEADPGSHAYRGRTERNASMFGPPGHAYVYFIYGMWFSLNLVCGPEGTASGVLLRGGEVIRGADLARGRRPKARHDRELAQGPARLATALDVDRSLNGTDLCAGPGAPLSVLGGTPVAAELVRSGPRTGVGGEGATHPWRFWTDGDPTVSPYRAHVPRNRGKGARQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBW6</accession>
    <name>A0A2G1XBW6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysoplasmalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_28770</name>
        <name evidence="10" type="ORF">CYQ11_06695</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48700">
        <property type="protein sequence ID" value="PHQ48700"/>
        <property type="gene ID" value="BLA24_28770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12619">
        <property type="protein sequence ID" value="PPT12619"/>
        <property type="gene ID" value="CYQ11_06695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304613" evidence="8">
        <location>
            <begin position="27"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="25786" checksum="FE9A1FD40313D387" modified="2018-01-31" version="1">MRRSAASRAARAAFAVAAATHLTALAAGATVLALATKPLLMPLLAVHVLTRGGPRLLAVALLFGCGGDVLLQCGGDALFRAGMGSFAAGHVCYLVLFARHGSPGGARTHRLAAGYAAAWLGTVTLLWPDLDADLRLPVAGYSLLLTAMALGATRARLWTAAGGALFLLSDTLIATGLAGWPQAPVPQFWVMLTYLAAQCLLAYGVRRCDGESGGTGLQPPGPSSDRRPAGRTSRSRQFLTAARASTMPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBW8</accession>
    <name>A0A2G1XBW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000158">
        <property type="protein sequence ID" value="PHQ48747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48747">
        <property type="protein sequence ID" value="PHQ48747"/>
        <property type="gene ID" value="BLA24_28165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="180" mass="19383" checksum="6C250F31F5DF96D5" modified="2018-01-31" version="1" fragment="single">PPRGHGRYPLRVRAIHRLLHRLPVADALAAVGGSFRVRALDGPLPEALDALAEAVREGGNAFVLAGDGRFHLLDAPDAGLLARTDRPRAWRELDAAVLHSALLEHVWEVPDDPEHIGYIHEAAAAVAQAERHGGTAVLMHPVHEDVVRELAEQGVTMPRKSTSFGPKPATGLVLRSLALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY4</accession>
    <name>A0A2G1XBY4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28850</name>
        <name evidence="2" type="ORF">CYQ11_06615</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48715">
        <property type="protein sequence ID" value="PHQ48715"/>
        <property type="gene ID" value="BLA24_28850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12604">
        <property type="protein sequence ID" value="PPT12604"/>
        <property type="gene ID" value="CYQ11_06615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="28188" checksum="C2BE07A0EFA4A8FA" modified="2018-01-31" version="1">MLNEHRSGRLTAWGNALLAGFAAPDDAAHHITGDDAVHRVADLPGESGPVGLTLALGRLRALGATGLRLALPVPGHPLGLSGPPEFNARAMEAEEAVLVSGLPLGLVPEVFEAGPEGDVHAEVLWRCLPVREAPPADVPSLSEAERELAEALREATEVLTRLDVAGSGPVAQAALEAYRARAERGREVLAPGYPPRAVRVLELAQRVGALVSIAYEPGDSEGREHGGAVSAAEITARSAALRPVERTARRAQVAAYNAMVEERSRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCA0</accession>
    <name>A0A2G1XCA0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_27825</name>
        <name evidence="9" type="ORF">CYQ11_17815</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48873">
        <property type="protein sequence ID" value="PHQ48873"/>
        <property type="gene ID" value="BLA24_27825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14480">
        <property type="protein sequence ID" value="PPT14480"/>
        <property type="gene ID" value="CYQ11_17815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="4"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="407" mass="41003" checksum="A4A312271F93CCAC" modified="2018-01-31" version="1">MRFRLLLLALGSFAMGTDSMVMAGILGLVADDLEVSVSAAGQMVTVFALAYALLAPVLATLTARWPRRRLLLAALALFTVANALSAVAPTYGLLLATRVLAAAGAALYTPSANAVATSLVPPEQRGRALATVMGGLTVATALGVPLGTYVGRVDWRLTMWLVVALGVLAFAGLAAFLRELPAPAASLGLRERLAPLRDRRVVEAAATTFMFFLAINAVYVYLATAVGGATGGDTGRLSVILLVTGVASVAGSWLGGRVVDRVGARAVMLAGGPVAALVYAALPWLGESMPGAVVYAVAAPLAGWVVAVALPHRLASLDPANAPLLISLNSSALYLGIAAGGGAGSIAIALLGERWFPLAATVLAVLATGLAAATTRERPGTVRATAPAAPGAAESGTPSPSGASGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB9</accession>
    <name>A0A2G1XCB9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27820</name>
        <name evidence="3" type="ORF">CYQ11_17820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48872">
        <property type="protein sequence ID" value="PHQ48872"/>
        <property type="gene ID" value="BLA24_27820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14481">
        <property type="protein sequence ID" value="PPT14481"/>
        <property type="gene ID" value="CYQ11_17820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="106" mass="11923" checksum="424A27A16D4B028E" modified="2018-01-31" version="1">MSGELLPQPAVEDIALEKVLQALGDPVRLHLFTVYANGEQYDCSSERLGVDHLHKSTISHHMRVMREAGVTSTRVVGRNRYVRLRREDLDTRFPGLVATLLRAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCI8</accession>
    <name>A0A2G1XCI8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22990</name>
        <name evidence="3" type="ORF">CYQ11_23085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48974">
        <property type="protein sequence ID" value="PHQ48974"/>
        <property type="gene ID" value="BLA24_22990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15381">
        <property type="protein sequence ID" value="PPT15381"/>
        <property type="gene ID" value="CYQ11_23085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="248" mass="26200" checksum="1656E89686103084" modified="2018-01-31" version="1">MTTTSPSPDPAAPARRARPGFGLLGPRRGRHELPPEQFETLALPVGDDGVVIGADEQGVAAVLGLGRPTPFDVVLVGGAWTAQVIALRTVGTGARVAVETGRRQLWTGLAQSANGGQQCVTLHDVGRVPPQGPSVHSPVLVVRDCGVRPPRGRVASSPWQSVLTLLPYLSPIAPRLMGHADLVGVQRVSPDEARQIGRLMRLSATDVEALSTLPDGVTLWCTRTSRMYVATQPTEPETGLLGAARRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCU3</accession>
    <name>A0A2G1XCU3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ORF">BLA24_23490</name>
        <name evidence="17" type="ORF">CYQ11_22580</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49056">
        <property type="protein sequence ID" value="PHQ49056"/>
        <property type="gene ID" value="BLA24_23490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15298">
        <property type="protein sequence ID" value="PPT15298"/>
        <property type="gene ID" value="CYQ11_22580"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ49056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT15298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="34600" checksum="613DD042696A6FF2" modified="2018-01-31" version="1">MTRCAVFGTGSWGTAFAMVLADAGCEVTMWGRRAALVDAVNTGRTNPDYLPGVELPAAVRATTDPAEAARDADFTVLAVPSQTLRGNLTAWTPLLAPDTVLVSLMKGVELGTAKRMSEVVEEVAGVSPDRVAVLTGPNLAKEIAARQPAAAVVACRDESVAKRLQAACHTAYFRPYTNTDVVGCELGGAVKNVIALAVGIADGMGLGDNAKASLITRGLAETTRLGLAMGADAHTFAGLAGMGDLVATCSSPLSRNHTFGTNLGRGMTLAETIAVTRQTAEGVKSCESVLDLAGRHHVDMPITETVVGIVHEGKPPMVALKELMSRSAKPERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD01</accession>
    <name>A0A2G1XD01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_24000</name>
        <name evidence="9" type="ORF">CYQ11_22070</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49137">
        <property type="protein sequence ID" value="PHQ49137"/>
        <property type="gene ID" value="BLA24_24000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15213">
        <property type="protein sequence ID" value="PPT15213"/>
        <property type="gene ID" value="CYQ11_22070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="563" mass="57036" checksum="9099EBC3C14B138F" modified="2018-01-31" version="1">MGLAMSTPVDEMDGPYKRRWAALGVLCLSLLIIVMANTSLTVAAPDMVQDLGLGSSDLQWVIDGYTVPYAALMLILGAVGDKYSRRGALVLGLFVFGAASIAGSLVDSPAGVIASRAVMGVGAAMIMPATLSLLAATFPRAERAKAITIWTATAGLAIAVGPLVAGALLEDHGWAATFLINVPIAVLGIVGALTLVPPSKAGRVDKIDYIGGLLSVIWVGSLIYMIIEGPHFGWGAKAIGAAVVAGVGLVCFVLWELRHPSPVLDVRRFTRRAFAGSTMAVALFFLAVFGAFYYLTQHLQFVLGYSPLDTGVRMLPLAGAVFVGGALTALLTPKLGMKVTVTLGMTVGTVAIALLARVDEHSGYGDFVLPLVVLGLAIGLSLSPCTNAIMGSFPEDQLGVGGAVNSTSIEMGGSLGIAILGTVLAKTYSSNLGDLAAKAAAAGGPKLPEKALTAAQDSVGAGLYVAKEAGKQVAAGAAPKVGAEKAAALGAQQAQTIAEAVHKAFADAVAHTSVVGAVVLGVGTVLVAFLLPGRAKTEAAETPAAGRSATPAEATESEPASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD63</accession>
    <name>A0A2G1XD63_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24020</name>
        <name evidence="2" type="ORF">CYQ11_22050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49141">
        <property type="protein sequence ID" value="PHQ49141"/>
        <property type="gene ID" value="BLA24_24020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15209">
        <property type="protein sequence ID" value="PPT15209"/>
        <property type="gene ID" value="CYQ11_22050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="158" mass="16995" checksum="CDE50B9A5325722A" modified="2018-01-31" version="1">MADSDTPRLPGLLPDAIHHAVRPGTALLRLETTQERGGVLDGAWWPRSRDIHAELPGLITALTEHLGPIMRVGLDGSAWEELPARLVVDDRVVHIDSFPVGDDTVLITRGDNDHFALLVVPPDTAPDAARAAMARAVRADNVTQAEQILIDTGGTPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD77</accession>
    <name>A0A2G1XD77_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_24365</name>
        <name evidence="7" type="ORF">CYQ11_21705</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49204">
        <property type="protein sequence ID" value="PHQ49204"/>
        <property type="gene ID" value="BLA24_24365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15146">
        <property type="protein sequence ID" value="PPT15146"/>
        <property type="gene ID" value="CYQ11_21705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="190" mass="20783" checksum="08F6CE2EC43B552A" modified="2018-01-31" version="1">MVHLTRIYTRTGDDGTTALGDMSRTVKTDTRIAAYADANEANAAIGVAIALGQLPAEVVKVLVRVQNDLFDVGADLATPVVEEPKYPPLRVEQSYIDKLEADCDRFLEPLEKLRSFILPGGTPGAALLHQACTVVRRAERSTWAALELHADIMNPLTATYLNRLSDLLFILARSANQEVGDVLWVPGENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC4</accession>
    <name>A0A2G1XDC4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">BLA24_24320</name>
        <name evidence="4" type="ORF">CYQ11_21750</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49195">
        <property type="protein sequence ID" value="PHQ49195"/>
        <property type="gene ID" value="BLA24_24320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15155">
        <property type="protein sequence ID" value="PPT15155"/>
        <property type="gene ID" value="CYQ11_21750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="24214" checksum="6BCA123E5F6742DF" modified="2018-01-31" version="1">MRLVIARCSVDYAGRLTAHLPSAPRLILVKADGSVSIHADDRAYKPLNWMSPPCTLKEGDGVWTVINKAGEKLIITMEEVLHDSSHELGVDPGLIKDGVEAHLQELLADRIETLGEGYTLIRREYPTAIGPVDILCRDADGQTVAVELKRRGDIDGVEQLTRYLELLNRDPHLAPVRGVFAAQEIKPQARVLATDRGIGCVVLDYDAMRGIEDDKLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDG1</accession>
    <name>A0A2G1XDG1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24510</name>
        <name evidence="5" type="ORF">CYQ11_21560</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49231">
        <property type="protein sequence ID" value="PHQ49231"/>
        <property type="gene ID" value="BLA24_24510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15118">
        <property type="protein sequence ID" value="PPT15118"/>
        <property type="gene ID" value="CYQ11_21560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="15870" checksum="C6B105B1D9D22FCC" modified="2018-01-31" version="1">MPGRVLVVDDNKVIRQLIRVNLELEGFEVVTAADGAECLEIVHRVRPDVVTLDVVMPRLDGLNTAARLRADTRTRDIPIAIISACTQPEADTGRPAGVDAFLAKPFEPAEMVRLVGRLVRYGRGEDVDGLPRAEAPGDAETVVHPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE43</accession>
    <name>A0A2G1XE43_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r4_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26030</name>
        <name evidence="3" type="ORF">CYQ11_20035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49498">
        <property type="protein sequence ID" value="PHQ49498"/>
        <property type="gene ID" value="BLA24_26030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14851">
        <property type="protein sequence ID" value="PPT14851"/>
        <property type="gene ID" value="CYQ11_20035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13725" checksum="0B1F3E3AB388B275" modified="2018-01-31" version="1">MTGYDRALVEHLLPAVWDDEAAYGIRNLQAPDADMPKGSVDPKTASLLFAHLADIRRGWVTAPLTPGERQAIVLRYGADLPDAEAATLQGVTDRAVRYRLERGVGKIAAHLNGRPYVDGYDGLAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEX7</accession>
    <name>A0A2G1XEX7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="17" type="ORF">BLA24_19235</name>
        <name evidence="18" type="ORF">CYQ11_11565</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49786">
        <property type="protein sequence ID" value="PHQ49786"/>
        <property type="gene ID" value="BLA24_19235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13438">
        <property type="protein sequence ID" value="PPT13438"/>
        <property type="gene ID" value="CYQ11_11565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="87"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="430"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="876"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ49786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT13438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="940" mass="105914" checksum="1C1CCBA06CDC6A1E" modified="2018-01-31" version="1">MSVFGKIMRAGEGKILRKLHRIADQVNSIEEDFVGLSDAELRALTEEYKQRYADGESLDDLMPEAFATVREAAKRVLGQRHYDVQLMGGAALHMGYVAEMKTGEGKTLVGTLPAYLNALSGDGVHLITVNDYLAERDSELMGRVHKFLGLSVGCILANMTPAQRREQYACDITYGTNNEFGFDYLRDNMAWSQEELVQRGHNFAVVDEVDSILVDEARTPLIISGPADQATKWYGDFAKLVTRLTKGEPANPQKGVEETGDYEVDEKKRTVAIHEAGVSKVEDWLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVMDGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYNKLSGMTGTAMTEAAEFHQIYKLGVVPIPTNRPMVRKDQSDLIYRTEVAKFAAVVEDIAEKHEKGQPILVGTTSVEKSEYLSQQLSKRGIQHEVLNAKHHEREASIVAQAGRKGAVTVATNMAGRGTDIKLGGNPDDLAEAELRQRGLDPVEHVEEWAAALPAALEKAEAAVKAEFEEVKELGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQMVERVMAMANVPDDVPIENKMVTRAIASAQSQVEQQNFETRKNVLKYDEVLNRQREVIYAERRRVLEGEDLHEQIQHFMDDTIDDYIRQETVEGFAEEWDLERLWSAFKQLYPVKVTIEELEEAAGDRAGITAEFIAESVKDDIHEQYAAREEQLGSDIMRELERRVVLSVLDRKWREHLYEMDYLQEGIGLRAMAQKDPLVEYQREGFDMFTAMMEGIKEESVGYLFNLEVQVDQQLEEVPVQDEERPSLQKVQDTVPAARPEIRAKGLAAPQRPDRLHFSAPTVDGEGGTIETDFASDDTGEFRSEADGLTRAERRKAQKNASGGRRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEY5</accession>
    <name>A0A2G1XEY5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26775</name>
        <name evidence="3" type="ORF">CYQ11_18860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49761">
        <property type="protein sequence ID" value="PHQ49761"/>
        <property type="gene ID" value="BLA24_26775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16659">
        <property type="protein sequence ID" value="PPT16659"/>
        <property type="gene ID" value="CYQ11_18860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="43031" checksum="20A4F2C8391FB4F0" modified="2018-01-31" version="1">MAFVESPVQLLNVLEWAYRGAGNALAPPPDAEPRPLRDGVPRQPAARDLTPLAGDLLVVVLAPHDPMTRGQLRRMCELARDQGHRVRWEEARSGPGAPVSTIGSLAGPLRRARRVVIGDPFSRYVQLLLTLTRARELIVVDDGTATMEFVSQLARGERLVRWHRRASWGARDLLFAPVSASARRKLTPKNRRRVEIFTSMPVEAPPGVTVTPNDFAWTRATYGPPRLTRGTDLVGTNLVETKVVDPERYLAAVAALARAHGATRYFAHRREHTDKLRRISTELGLEVVRPELPLELVARRGPVGRTVLSFPSTVVHTLPLALAGAGVTVAVCDIDPSWLTEDASPRAEDFLSGVSGTARDVRHLPYTPVTAPQGPKYGSYPPPDPSMRLNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF22</accession>
    <name>A0A2G1XF22_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_26760</name>
        <name evidence="7" type="ORF">CYQ11_18875</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49759">
        <property type="protein sequence ID" value="PHQ49759"/>
        <property type="gene ID" value="BLA24_26760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16661">
        <property type="protein sequence ID" value="PPT16661"/>
        <property type="gene ID" value="CYQ11_18875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="237"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="539" mass="57632" checksum="A152801CA24106DC" modified="2018-01-31" version="1">MANHDIHLTVRRGTVHALCGENGAGKSTLMKILYGMQKPDEGTITLDGEQVTLHTPADAIGRGIGMVHQHFMLADNLTVLENVVLGAEKLHGIGNKARKKIKEISDAYGLGVRPDVLVEDLGVADRQRVEILKVLYRGARTLILDEPTAVLVPQEVDALFDNLRELKSEGLTVIFISHKLGEVLSVADDITVIRRGTTVGTAVPSETTPKQLAELMVGEELPSPETRESTVTDTPMLTVDGLHLSATDSDGVVRAVLDGITFTIHKGEVLGLAGVEGNGQAELVEAIMGMRTPDGGTVTLDGADITTAPTRKRREGGIGYIPEDRHRHGLLLEAPLWENRILGHVTEKPNSKGGLLDIKAAREDTERIVREYDVRTPGIEVTAASLSGGNQQKLIVGREMSHEPKLLIAAHPTRGVDVGAQAQIWDQIREARREGLAVLLISADLDELIGLSDTLRVMFRGRLVADADPATITPEELGSAMTGAATGHLEHTEDGEATQTAEEPGETPDAPVDAEAPKDAEAPEAGDDTTEKPEGGDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF27</accession>
    <name>A0A2G1XF27_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19545</name>
        <name evidence="3" type="ORF">CYQ11_11250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49838">
        <property type="protein sequence ID" value="PHQ49838"/>
        <property type="gene ID" value="BLA24_19545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13386">
        <property type="protein sequence ID" value="PPT13386"/>
        <property type="gene ID" value="CYQ11_11250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="339" mass="37228" checksum="48F04851313D6C27" modified="2018-01-31" version="1">MEKNPPPVSRRAAVRPWLICLTALAAVWWACVAVSDYFTAVAGGPVRSAEDFRKRDIATRQAGDRTVRALRPGAGKPEWARADDGSTSCVDDLGFDDGDVTRKQPGYVWRLSYSGKDAYMTDLGKLREAWEDRGLKVQDLPPPEQLNPARPLPDWPGIRTTDEHGVAIRMNLNRYTGEPNVTTDGGCVRYDRAAKVTARTREGAAGGHTAKEGRVVYRDGTEVTIGAVQPFTPTPEMLPPSTPTPAHAYRVTVTVTNKSGAALELRRYETGAWARTNPDLTELSAYTTGFDTTSPTRVAPGETTHFEFAYAAQEKPPHLDFAFGPGDLHTPYTWRLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF38</accession>
    <name>A0A2G1XF38_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Translation initiation factor IF-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19560</name>
        <name evidence="3" type="ORF">CYQ11_11235</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49840">
        <property type="protein sequence ID" value="PHQ49840"/>
        <property type="gene ID" value="BLA24_19560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13384">
        <property type="protein sequence ID" value="PPT13384"/>
        <property type="gene ID" value="CYQ11_11235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="31124" checksum="ECD502E9764E361E" modified="2018-01-31" version="1">MPHYTSYDAVDLHYRVLGPGTGTPVVCLAGGPGRDAAYLGDLGGLDAHHTLVVPDSRGTGASPPAPDPARYAFPALAEDVEALRRHLGVERLALLAHDAACATAQAYAAAHGDRLSRLVLVTPGSRLQGELPTDAEEIFESRAAEDWWVDAYVAVHSLPNATGLDEVRDLLRRAAPLAYARWDAPQRAHAATEPDQLGPVPRAGFWQGVDEATRRALLRRLREVACPVLVVTGDRDAVSGMRAGEAVAASFPHAVLRPLHEVGHYPWVDEPELFRPLVTEFLRETPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF44</accession>
    <name>A0A2G1XF44_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_19620</name>
        <name evidence="8" type="ORF">CYQ11_11175</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49852">
        <property type="protein sequence ID" value="PHQ49852"/>
        <property type="gene ID" value="BLA24_19620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13372">
        <property type="protein sequence ID" value="PPT13372"/>
        <property type="gene ID" value="CYQ11_11175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="6">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="56" mass="6540" checksum="0C9EAA2931D03F64" modified="2018-01-31" version="1">MEYKSWMCPICGWLYEEEMGLPEEAIARGTRWVDVPADWTCPESGNPKKDFEMVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFE3</accession>
    <name>A0A2G1XFE3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20070</name>
        <name evidence="5" type="ORF">CYQ11_10720</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49925">
        <property type="protein sequence ID" value="PHQ49925"/>
        <property type="gene ID" value="BLA24_20070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13299">
        <property type="protein sequence ID" value="PPT13299"/>
        <property type="gene ID" value="CYQ11_10720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="234"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="443" mass="47775" checksum="3FB90B43778584F3" modified="2018-01-31" version="1">MSQDSTTVPETARKLSGRRRREIVAVLLFSGGPIFESSIPLSVFGIDRQDAGVPRYRLLVCAGEDVPLRTTGGLELTAPYGLEALSRAGTVVVPAWRSITQPPPAAALDALRRAHEEGARIVGLCTGAFVLAAAGLLDGRPATTHWMYAPTLAKRYPSVHVDPRELFVDDGDVLTSAGTAAGIDLCLHIVRTDHGADAAGALARRLVVPPRRSGGQERYLDRSLPEEIGADPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYRARRPQGGTVDRPERGERADRAERGDRFDRPEPVEPRAGEPSLMAMRRTALAASHAMTGAPLGAAPPHSGHIGHMPGHGGGPGANAADPGKPESDLYTPRLPGQRERPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFK3</accession>
    <name>A0A2G1XFK3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20435</name>
        <name evidence="2" type="ORF">CYQ11_10350</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49985">
        <property type="protein sequence ID" value="PHQ49985"/>
        <property type="gene ID" value="BLA24_20435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13238">
        <property type="protein sequence ID" value="PPT13238"/>
        <property type="gene ID" value="CYQ11_10350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038500">
        <property type="entry name" value="Antitermination_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="9254" checksum="0E49BC5CA0AFA2E4" modified="2018-01-31" version="1">MTPTLLAITCLIIVTLGYAAMCAASPFGRCRKCRGLGFAMKTDRKGRPRRGRPCRRCDGHGIRIRVGRHLYNAAARLHRDGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFP5</accession>
    <name>A0A2G1XFP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20930</name>
        <name evidence="4" type="ORF">CYQ11_09850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50066">
        <property type="protein sequence ID" value="PHQ50066"/>
        <property type="gene ID" value="BLA24_20930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13153">
        <property type="protein sequence ID" value="PPT13153"/>
        <property type="gene ID" value="CYQ11_09850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="2">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="27717" checksum="BAF35C8DC3D3C36B" modified="2018-01-31" version="1">MQRIRLRYTKRGRLRFTSHRDFQRAFERALRRAEVPMAYSAGFTPHPKVSYANAAPTGTGSEAEYLEIQLAEARDPAVLRDLLDESLPDGLDITDAVEAHTSSFADRLQASVWELRLEGVELKDAEKAVAAFMAAETVEVQRRTKNGLRTFDARGAVTRLEALAAPADRPGDGACAILRLVVRHSTPAVRPDDVLSGLRATADLAPPVPAAVTRLAQGLLDDETGTVTDPLAPDRDAAPAASTTAAGPSAAQQVPEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ1</accession>
    <name>A0A2G1XFQ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_20895</name>
        <name evidence="10" type="ORF">CYQ11_09885</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50063">
        <property type="protein sequence ID" value="PHQ50063"/>
        <property type="gene ID" value="BLA24_20895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13157">
        <property type="protein sequence ID" value="PPT13157"/>
        <property type="gene ID" value="CYQ11_09885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="42337" checksum="BF6701C967E3234F" modified="2018-01-31" version="1">MTAAEGYPLRRFSPERGAWSRLTARDSVLRRLDWVMLLAALALSGIGTLLVYSATRNRTELNQGDPYYFLLRNVLNTGIGLALALGAVWLGHRALRGAVPILYAISLLFTLAVLTPLGATINGARSWIQLGGGFSIQPSEFTKITITLGMAMLLAGKVDAGDRRQPDHRTVMEALGLAALPIVVILLMPDLGSVMVLVVIVLAVLLSSGASNRWVLGLVGAGVLGCVLIWQLGVLDEYQINRFAAFANPALDPSGVGYNTNQARIAIGSGGLTGAGLFHGSQTTGQFVPEQQTDFIFTVAGEELGFVGAGAIIFLLGVVLWRACRIARESTELYGTIVAAGVIAWFAFQSFENIGMTLGIMPVTGLPLPFVSYGGSSMFAAWIAVGLLQSIKAQRPMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFU1</accession>
    <name>A0A2G1XFU1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21165</name>
        <name evidence="3" type="ORF">CYQ11_09620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50103">
        <property type="protein sequence ID" value="PHQ50103"/>
        <property type="gene ID" value="BLA24_21165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13116">
        <property type="protein sequence ID" value="PPT13116"/>
        <property type="gene ID" value="CYQ11_09620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="125" mass="14805" checksum="8E4AA339910A4B56" modified="2018-01-31" version="1">MSAGHGEGPTLDERVRRWEWFVSEVEEGFDTTWVWEYDQDIRCRDWLHDAWPILTERIRAHYQGELDALDDRFLAATAPIRPHGAGAVANPERWWRHRYPQRVSGTRREDHLPPTWSPTPAYVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG11</accession>
    <name>A0A2G1XG11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21635</name>
        <name evidence="3" type="ORF">CYQ11_09150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50180">
        <property type="protein sequence ID" value="PHQ50180"/>
        <property type="gene ID" value="BLA24_21635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13037">
        <property type="protein sequence ID" value="PPT13037"/>
        <property type="gene ID" value="CYQ11_09150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="28395" checksum="47178D47D0B890DC" modified="2018-01-31" version="1">MESLRMIENWPVETAAAAVVRADGTVAGRCGPTGHRFPLASVTKPLAAYAALIAVEEGAVELDEPAGPEGATVRHLLAHTAGLAFDEHRAVAAPGTRRLYSNAGFEVLGDHIAKATDIPFAAYLREAVLEPLGMTATDLPGSPAKDGVSTVDDLALFAAELQAPRLLSRATLAEATSVVFPGLTGVLPGYGHQRPNDWGLGFEIRDGKSPHWTGLSSSPRTYGHFGQSGTFLWVDPDAGAACVALADRAFGPWAVEAWPPLTDAVLAELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG40</accession>
    <name>A0A2G1XG40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21775</name>
        <name evidence="4" type="ORF">CYQ11_09010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50204">
        <property type="protein sequence ID" value="PHQ50204"/>
        <property type="gene ID" value="BLA24_21775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13012">
        <property type="protein sequence ID" value="PPT13012"/>
        <property type="gene ID" value="CYQ11_09010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="34366" checksum="279D8376AEA2EE8C" modified="2018-01-31" version="1">MELEVRHLRALCAIADTGSVRKAALQLGMTQPSLTTQLRRIETSLGGMLFTRGQTGSRPTPLGHSVLSRARPIIAEMTALVSAARDAAGGVGGLRLRIGSIGSRAVTGWLRRIHQRLPDTDTTIHIDVSSNTLLQLLATNQLDVAFVQETPGLPLAVPPGVERRVLIACEPRFVCLSDRHRAAGRPAVRLRELAHDAWIVDPTADDEVTALRRVFTAAGLDPRLVHVRDATTAAELVASGEAVRPAQPTAAPAPGTVIRPLHGDPLTAQLSLASRPGSLPLPQLDALFADLMASYVDLAAADTTYRAWLDRSGSPLLPSVGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG51</accession>
    <name>A0A2G1XG51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21860</name>
        <name evidence="3" type="ORF">CYQ11_08925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50218">
        <property type="protein sequence ID" value="PHQ50218"/>
        <property type="gene ID" value="BLA24_21860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12998">
        <property type="protein sequence ID" value="PPT12998"/>
        <property type="gene ID" value="CYQ11_08925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="133" mass="15163" checksum="EE34C72824CEBF3D" modified="2018-01-31" version="1">MATMAGRSRAEIEADIKETLGLVPHFLAGIPDDLLESEWEIFKKLELGETLIPNKYKELMGIALHSETKCRYCTLFHTEAARLYGATDEEIQEAVHYAKNSLGWSAYLNGMREDYDDFAKELEQIKDYLNAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGA5</accession>
    <name>A0A2G1XGA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyroglutamyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21580</name>
        <name evidence="4" type="ORF">CYQ11_09205</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50169">
        <property type="protein sequence ID" value="PHQ50169"/>
        <property type="gene ID" value="BLA24_21580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16443">
        <property type="protein sequence ID" value="PPT16443"/>
        <property type="gene ID" value="CYQ11_09205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304900" evidence="2">
        <location>
            <begin position="42"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="437" mass="46168" checksum="12848FA04924BD3C" modified="2018-01-31" version="1">MRPTHITAPVSRAPRRTRLAVLGTALLACAPLALTAVPASAAPAAAPPTVEEQRLDGAVPQEILRRSGFDDVAPGFARALAGTRSLDQARRLAAEDGRRLWRRAVDRAQGRGPAGGDLSADDDRPLYWARLGMTRALREWRPAFSLDEGRRADLVARLERGSRGQDSVELPTGSAVKRVVITGFDPFQLDSDIRRSNPSGAAALALDGTTIQTPAGPARVEAAVFPVRWEDFAGGTVERTLLPHFTPGPGRVDLFTTISQGRPGRFDVERTNGAWRGGSPDNVNLSRTGTVPVPRGLPTVTPQPQWTTTSLPYAALTATPTGRFPVRDNTSVTEIPAGGTEEADRPDGPTPGSTARAGGGGDYLSNEIAYRATLLRDAVRLRVPGGHLHTPVLSFGAGNTDPANGRVTDPSFVADRLAITAQIRSLLAVAVGSGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGF1</accession>
    <name>A0A2G1XGF1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21865</name>
        <name evidence="2" type="ORF">CYQ11_08920</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50219">
        <property type="protein sequence ID" value="PHQ50219"/>
        <property type="gene ID" value="BLA24_21865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12997">
        <property type="protein sequence ID" value="PPT12997"/>
        <property type="gene ID" value="CYQ11_08920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="68" mass="7650" checksum="6C703107BB22179D" modified="2018-01-31" version="1">MELEWVRPGVLRVTSHAYEFAALVAAARYVTESAPAEIPEEALEQMRGVLADYDTRLREATARSEEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGM0</accession>
    <name>A0A2G1XGM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20215</name>
        <name evidence="3" type="ORF">CYQ11_10575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50376">
        <property type="protein sequence ID" value="PHQ50376"/>
        <property type="gene ID" value="BLA24_20215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16476">
        <property type="protein sequence ID" value="PPT16476"/>
        <property type="gene ID" value="CYQ11_10575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009334">
        <property type="entry name" value="DUF993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06187">
        <property type="entry name" value="DUF993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="381" mass="40397" checksum="26FB672E56745B4E" modified="2018-01-31" version="1">MPDASGRLRRHVPRAAAHPPPKGPPPASRVLLAAAHVVADPFGDTTPHGPARLDWEATLAFRRHLWAHGLGVAEAMDTAQRGMGLDWPAAARLIRLSAAEAKAVGGRIVCGAGTDQLRPPYARLADVAAAYEEQLAVVEEAGAPAVVMCSRALAAVATGPECYEEVYGRLLRQAAAPVILHWLGPAFDPALEGYWGATDPGAALETFLRIVTAHAGKVEGVKVSLLDAGTERALRRRLPPRVRCYTGDDLHYPALIEGDGQGHSDALLGVLDPLGPLAARATRLLDAGDGRGFRALLDPTVALARHLFEPPTRFYKTGIVLLAWLAGHQGHFTMAGGLHAGRSLPHLARAYELADDLGLFPDPERAEARMASLLAVHGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGW4</accession>
    <name>A0A2G1XGW4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folB</name>
        <name evidence="3" type="ORF">BLA24_16550</name>
        <name evidence="4" type="ORF">CYQ11_16735</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50455">
        <property type="protein sequence ID" value="PHQ50455"/>
        <property type="gene ID" value="BLA24_16550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14290">
        <property type="protein sequence ID" value="PPT14290"/>
        <property type="gene ID" value="CYQ11_16735"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="119" mass="13227" checksum="AAF8542BB5D4F3A5" modified="2018-01-31" version="1">MDRVALRGLKARGHHGVFPREREEGQTFIVDLVLSLDTRPAAADDDLAKTVHYGIVAEEVVDIVQGEPVDLIETLAERIAEQCLKHDPVREVEVVVHKPDAPITVPFDDVTITITRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGZ0</accession>
    <name>A0A2G1XGZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAD-IB family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Inhibition of morphological differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16825</name>
        <name evidence="4" type="ORF">CYQ11_16460</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50497">
        <property type="protein sequence ID" value="PHQ50497"/>
        <property type="gene ID" value="BLA24_16825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14248">
        <property type="protein sequence ID" value="PPT14248"/>
        <property type="gene ID" value="CYQ11_16460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="299" mass="32630" checksum="1B31AD7C375FA954" modified="2018-01-31" version="1">MLGGVENHSLPRTAAFFDLDKTVIAKSSTLTFSKSFYQGGLINKRAVLRTAYAQFVFMAGGADHEQMERMRQYLSALCQGWNVQQVREIVAETLHELIDPIIYDEAASLIEEHHAAGRDVVIVSTSGAEVVEPIGALLGADRVVATRMVVEDGAFTGEVEYYAYGPTKAEAIRELAASEGYDLTRCYAYSDSVTDIPMLESVGHPHAVNPDRGLRREAMARDWPVLSFSRPVRLKQRVRALPMPSRPALVAAAAFGAAAATAGLVWLANRRRTPASALSAFSVKSKELRPGLPLPSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH74</accession>
    <name>A0A2G1XH74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17395</name>
        <name evidence="4" type="ORF">CYQ11_15880</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50582">
        <property type="protein sequence ID" value="PHQ50582"/>
        <property type="gene ID" value="BLA24_17395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14163">
        <property type="protein sequence ID" value="PPT14163"/>
        <property type="gene ID" value="CYQ11_15880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="56"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="241" mass="25590" checksum="4D39E374A0F08ED7" modified="2018-01-31" version="1">MNLILQALPVAVPTIGWVTHACYLGRRVRAARTDRLTGLMRREEFTARARKAVRHPHAVVLLLDLNGFKQINDTHGHDVGDQVIAAVGRRLAAWCRERGGFAARLGGDEFTAVVRIAPGTDPAAEMAHLSARLSAPLDTGRVTLAPRASIGLCHTGHRPGAGLSELLRGADEAMYAAKRRGDPWRPATAGAGTGGEAAPAARHGAGGTDLRDRRAATAPGRRPGRPAPHLTLLPPARRRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHE2</accession>
    <name>A0A2G1XHE2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_17590</name>
        <name evidence="7" type="ORF">CYQ11_15685</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50611">
        <property type="protein sequence ID" value="PHQ50611"/>
        <property type="gene ID" value="BLA24_17590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14134">
        <property type="protein sequence ID" value="PPT14134"/>
        <property type="gene ID" value="CYQ11_15685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="342" mass="36102" checksum="188135E2CAE12CAA" modified="2018-01-31" version="1">MIATESLSKRFPRVTALDRLSVDITPGVTGLVGANGAGKSTLIKILLGLSPATEGSARVLGLDVATEGSKIREQVGYMPEHDCLPPDVSATEFVVHMARMSGLPPTAARERTADTLRHVGLYEERYRPMGGYSTGMKQRVKLAQALVHDPRLVLLDEPTNGLDPVGRDEMLGLIRRVHTDFGISVLVTSHLLGELERTCDHVVVIDGGKLLRSSSTSDFTQDTGSLAVEVTDTDAHPDGTSALMSALTAAGLTVQPAGRAAGAEYAAAGSGHVLLVDVAGDATYDAVRDAVAGLGLGLVRMEQRRHRIAEVFKSADDPEGVLTEDTHPHDVRPHEGGAVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHE6</accession>
    <name>A0A2G1XHE6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_17825</name>
        <name evidence="7" type="ORF">CYQ11_15450</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50653">
        <property type="protein sequence ID" value="PHQ50653"/>
        <property type="gene ID" value="BLA24_17825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14092">
        <property type="protein sequence ID" value="PPT14092"/>
        <property type="gene ID" value="CYQ11_15450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="194" mass="19649" checksum="B7442D754DCB37B4" modified="2018-01-31" version="1">MAGETVITVVGNLVDDPELRFTPSGAAVAKFRVASTPRTFDRQTNEWKDGESLFLTCSVWRQAAENVAESLQRGMRVIVQGRLKQRSYEDREGVKRTVYELDVEEVGASLKNATAKVTKTAGRGGQGGGYGGGAGGGQGGGWGSGPGGQQGGGAPADDPWATGAPSGNQPGGGGGGWGGGSGNSGGGYSDEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHH5</accession>
    <name>A0A2G1XHH5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">BLA24_17815</name>
        <name evidence="10" type="ORF">CYQ11_15460</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50651">
        <property type="protein sequence ID" value="PHQ50651"/>
        <property type="gene ID" value="BLA24_17815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14094">
        <property type="protein sequence ID" value="PPT14094"/>
        <property type="gene ID" value="CYQ11_15460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="148" mass="15715" checksum="6C2B606172D7FD82" modified="2018-01-31" version="1">MKIILTHEVSGLGTAGDVVDVKDGYARNYLVPRGFAIRWTKGGEQDVAQIRRARKIREIATIEQANEVKGQLEGVKVRLATRAGEAGRLFGSVTPADIAAAIEASGGPKVDKRRVEVGSPIKTLGAHQVSVRLHADVVAKLGIEVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHM2</accession>
    <name>A0A2G1XHM2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18255</name>
        <name evidence="4" type="ORF">CYQ11_15020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50726">
        <property type="protein sequence ID" value="PHQ50726"/>
        <property type="gene ID" value="BLA24_18255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14018">
        <property type="protein sequence ID" value="PPT14018"/>
        <property type="gene ID" value="CYQ11_15020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="38374" checksum="7E6405345E97672F" modified="2018-01-31" version="1">MKLPPQDAVAHGGRHEPEHQILLPRYAVAPIRQVGRRILVALLVMVATVLIVYADRGGYHDNADGGVDFLDAVYYSTVTLSTTGYGDIVPYSDSARLTNVLLVTPLRVLFLIILVGTTLEVLTERTREQWRLARWRSAVREHTVVVGFGTKGRSAASTICGPHASPRERERIVVVDPNPKAAEAATAEGYVAVVGDATRSDVLLRAEVQKARQVIIATQRDDTAVLVTLTARQLNRGAKIVAAVREEENAPLLRQSGADSVITSASAAGRLLGLSVLSTGAGTVMEDLIQQGSGLDLVERPVVKSEVGRGVRETEDLVVSVLRGHRLLAYDDPEASPLKATDRVITIVRARPPGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHQ1</accession>
    <name>A0A2G1XHQ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_18380</name>
        <name evidence="11" type="ORF">CYQ11_14900</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50747">
        <property type="protein sequence ID" value="PHQ50747"/>
        <property type="gene ID" value="BLA24_18380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13995">
        <property type="protein sequence ID" value="PPT13995"/>
        <property type="gene ID" value="CYQ11_14900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01153">
        <property type="entry name" value="ACAD_fadE5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034188">
        <property type="entry name" value="FadE5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="286"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="472"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="608" mass="66486" checksum="49880A92CB26454C" modified="2018-01-31" version="1">MGHYKSNLRDIEFNLFEVLGRDKLYGTGPFGEMDVETAKSVLSEIARLSENELAASFVDTDRNPPVFDPETNTAPVPEAFKKSYQAYMDAEWWRLGIPEGIGGTTTPRSLLWGFAETILGSNPAVWMYSSGPAFAGVLYDEGTEQQKHIAKLAVDKQWGSTMVLTEPDAGSDVGAGRTKAVKQEDGSWHIEGVKRFITSGEHDMAENILHYVLARPEGAGPGTKGLSLFLVPKYEFDFETGELGARNGVYATNVEHKMGLKASNTCEMTFGDKHPAKGWLIGEKHDGIRQMFMIIEFARMMVGTKAIATLSTGYLNALEYAKERVQGPDLANFMDKSAPKVTITHHPDVRRSLMTQKAYAEGMRALVLYTASVQDEILVKEAAGEDAKALHGLNDLLLPIVKGYGSEKSYEQLAQSLQTFGGSGYLQEYPIEQYIRDSKIDTLYEGTTAIQGQDFFFRKIVRDQGQALTTLSEEIKKFLAEAAGGEDLADAREKLARAAVDLEGIVGAMLTDLAATEKDVKSIYKVGLNTTRLLMASGDVVVAYLLLKGAAVAAEKLPTASTKDKAFYEGKIAAAKFFAHTVLPNLAVERALAESVDQSLMELDEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHR4</accession>
    <name>A0A2G1XHR4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="10" type="ORF">BLA24_18630</name>
        <name evidence="11" type="ORF">CYQ11_14650</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50788">
        <property type="protein sequence ID" value="PHQ50788"/>
        <property type="gene ID" value="BLA24_18630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13954">
        <property type="protein sequence ID" value="PPT13954"/>
        <property type="gene ID" value="CYQ11_14650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="618" mass="66399" checksum="93A836578C22D476" modified="2018-01-31" version="1">MARAVGIDLGTTNSVVSVLEGGEPTVITNAEGARTTPSVVAFAKNGEVLVGEVAKRQAVTNVDRTIRSVKRHMGTDWKINLDGKDFNPQQMSAFILQKLKRDAEAYLGEKVVDAVITVPAYFNDSERQATKEAGEIAGLNVLRIVNEPTAAALAYGLDKDDQTILVFDLGGGTFDVSLLEIGDGVVEVKATNGDNHLGGDDWDQRVVDYLVKQFHSGHGVDLSKDKMALQRLREAAEKAKIELSSSTETSINLPYITASAEGPLHLDEKLTRAQFQQLTADLLERCKTPFHNVIKDAGISLSEIDHVVLVGGSTRMPAVAELVKELTGGKEANKGVNPDEVVAIGASLQAGVLKGEVKDVLLLDVTPLSLGIETKGGIMTKLIERNTTIPTKRSEIFTTAEDNQPSVQIQVYQGEREIAAYNKKLGMFELTGLPPAPRGVPQIEVSFDIDANGIMHVTAKDLGTGKEQKMTVTGGSSLAKDEVDRMRQEAEQYAEEDHRRREAAETRNQGEQLVYQTEKFLKDNEDKVPGEVKTEVETAVSELKEKLKGEDTAEIRTATEKVAAVSQKLGQAMYADAQAAQGAAGAAGADAGQQAKAEDDVVDAEIVDDEKPKGGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI44</accession>
    <name>A0A2G1XI44_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_19050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50922">
        <property type="protein sequence ID" value="PHQ50922"/>
        <property type="gene ID" value="BLA24_19050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NPCBM" evidence="6">
        <location>
            <begin position="435"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="580" mass="59569" checksum="09F10306A01F0FC3" modified="2018-01-31" version="1">MRGGADDDAYEELYRRHAGAVRRYARSCCRDDHTAEDLTNEVFAATLQAIRAGAGPDSAVRAYLLTTVRRVAAAWGRTAKREQLVDDFAVFATSAASSSATAEDDTLDPGADVRAMQEAEQSLAVQAFRSLPERWQTVLWHTTVEEESPSEVAPLLGLSPNATAVLAHRAREGLKQAYLQAHVSTSLTSGGECAQYADRLGAYARGRLRTRAERGMRKHLEGCARCRGAALEVADVNERLRALLPTAVIGWFAAGWSVKAAAGWAAGAGAAAGAASAGAGTGPASGGAGAPGPGALGGHGLGVAAKAGLAAGVVAATGAVLAYALAGGSPAPDRPRAEPREAAPAVPAPVPTAPRSLTASSAAVSPPARAAHPVVPRPSASPTPSRTPAKAVALPAPAPASPRPSVTTPARKPPASHKPEPKAKPKPNPPPAPSAPSVGYRLNELDYGLTGGGTEPEVRLGGSSWLWQRYGLRVGGRAYGHGASVHASSSVTIDLNRSCTAYDALAGVDDMTEGVGAVTFSVYADGERLWTSPLVHGGRAPVAVHVPLAGRRTLRLVVEPRGPLDRGALADWALARIACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIA7</accession>
    <name>A0A2G1XIA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyglutarate oxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">L-2-hydroxyglutarate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19035</name>
        <name evidence="3" type="ORF">CYQ11_14245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50921">
        <property type="protein sequence ID" value="PHQ50921"/>
        <property type="gene ID" value="BLA24_19035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16554">
        <property type="protein sequence ID" value="PPT16554"/>
        <property type="gene ID" value="CYQ11_14245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="18"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="414" mass="43845" checksum="65D0557EE46E7A40" modified="2018-01-31" version="1">MIGPVGGEALKSWGYDCDVLIVGGGIVGLSTAYALTRAAPRTRVVVLEKESGPARHQTGRNSGVIHSGVYYRPGSYKARFAVQGAAEMVAFCAEQELPHAVTGKLVVATERSELPRLHALVQRGRANGIPVRELGPAQIAEYEPRVRGLGAVHVGTTGVCDFGAVARRLAELAEDAGASVRYGAEVRTIGRRGSVVAVRTADGEVLRARALVNCAGLHSDRVARLAGDDPGMRIVPFRGEYFELAADRADLVRGLVYPVPDPAFPFLGVHLTRGVDGSVHLGPNAVPALAREGYGWGAVRPGELAGTVAYPGAWRIARRHWRYGAGEIRRSLSKPAFTRAVRRLLPEVRPEDLIPAASGVRAQAVLRDGTLVDDFLFAESPGMVHVLNAPSPAATASLPIGREVARRVLAGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIF9</accession>
    <name>A0A2G1XIF9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="9" type="ORF">BLA24_14630</name>
        <name evidence="10" type="ORF">CYQ11_13440</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_071961684.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51016">
        <property type="protein sequence ID" value="PHQ51016"/>
        <property type="gene ID" value="BLA24_14630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13761">
        <property type="protein sequence ID" value="PPT13761"/>
        <property type="gene ID" value="CYQ11_13440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="96" mass="10517" checksum="F07948E703E6A38D" modified="2018-01-31" version="1">MTEALGSTATPESGRPEDEVATKKGRRGGKRGKKGPLGRLALFYRQVVAELRKVVWPTKSQLSTYTTVVIVFVVIVIGLVTVIDYGFEQAVKYVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIR0</accession>
    <name>A0A2G1XIR0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_10295</name>
        <name evidence="5" type="ORF">BLA24_10310</name>
        <name evidence="3" type="ORF">BLA24_15195</name>
        <name evidence="6" type="ORF">CYQ11_12875</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000115">
        <property type="protein sequence ID" value="PHQ51991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000115">
        <property type="protein sequence ID" value="PHQ51992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51117">
        <property type="protein sequence ID" value="PHQ51117"/>
        <property type="gene ID" value="BLA24_15195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51991">
        <property type="protein sequence ID" value="PHQ51991"/>
        <property type="gene ID" value="BLA24_10295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51992">
        <property type="protein sequence ID" value="PHQ51992"/>
        <property type="gene ID" value="BLA24_10310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13660">
        <property type="protein sequence ID" value="PPT13660"/>
        <property type="gene ID" value="CYQ11_12875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19352">
        <property type="entry name" value="TetR_C_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="23314" checksum="2331A36F9FD5EDB4" modified="2018-01-31" version="1">MTGQVRTVDGRVAGRRGQATRQKLLDCLGEMLSSSPYRDVKVIDVARKAGTSPATFYQYFPDVEGAVLEIAEEMAKEGASLTELVASRSWVGRSGWQAAEELVDGFLGFWRKHDAILRVVDLGAAEGDKRFYKIRMKILNAVTNSLTDSVKELQSKGKVDKDVNPAAVAGSLVAMLAAVASHQKGFQSWGVKQAELKPNLALLVHLGITGKKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ05</accession>
    <name>A0A2G1XJ05_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_15205</name>
        <name evidence="10" type="ORF">CYQ11_12865</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51119">
        <property type="protein sequence ID" value="PHQ51119"/>
        <property type="gene ID" value="BLA24_15205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13658">
        <property type="protein sequence ID" value="PPT13658"/>
        <property type="gene ID" value="CYQ11_12865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="844" mass="87079" checksum="CE98A338A9862292" modified="2018-01-31" version="1">MVEQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIITECGPLPAQAVRWLAAGVAEALQSIHGAGLVHRDLKPSNVLVVEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQARDSRSVTGASDIFSLGSTLVFAATGHAPFHGANPVETVFMLLREGPDLSGLPDELRPLIDSCMQMAAENRPSPADLQAQLAPHLFASGGGDDSGTASAWLPDNAVSLIEQRRAGHRPAAAGQAGGRGRVSAPPRPTQPPAPEPVAAHEPPAGRAPAAWGSAHAGSGATGRSGAVGAPDPRGGLSGPHGVPAGALPGAAHGRHAGAPAAAPDGTVRLAGSQVPIGPGPRVADAREPHDRAAGATTGWVRPPAGASAAALPGQPPAPAPAPAPAPDGATNPQADPGRWRPWRFRMSNDVWGTPVVAGDLLYVTSFEVHALDVASGRRQFKTRDVAWAMAVADGRIHASDGPTLYALDAADGAERWRLSTDGWVYSLKADRGTIVTGTRGGGVQAWEAANGELLWEMSGAQTDFETPDCGPQVHDGTVYVWADARLRALEARTGVERWSYPVGDAPSCGGVPVRLLAAPDGVVYVAAGTRVLAIDVARGDVRWRFEAPAVFLSPPAFAPGPSVTGGGVYVADYLGTVYALDAATGRDRWRIATEARQSAEPVLVAAGAVHLGSGGALYTLDAVTGTPRWRFAAGGDIVGAPVVADGRVHFGSADHCLYTVDAAGGQLRWKLATGGEITGSPVATGGVVYACSKDRCVYALDAAKGTGAQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ25</accession>
    <name>A0A2G1XJ25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16010</name>
        <name evidence="6" type="ORF">CYQ11_12065</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51254">
        <property type="protein sequence ID" value="PHQ51254"/>
        <property type="gene ID" value="BLA24_16010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13520">
        <property type="protein sequence ID" value="PPT13520"/>
        <property type="gene ID" value="CYQ11_12065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758869" evidence="3">
        <location>
            <begin position="41"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="302"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="36042" checksum="08B6F3535C1A9B24" modified="2018-01-31" version="1">MRSGTGRHRRPRQVPAIVVAAGVTGASIAMPLLAATGANAADADTWDHVAQCESGGVWSANSESGYYGGLMLTQEMWDQNGGTAYAPRPDMASRAQQITVADRILRARGADSWKGCGAGLTKEEQTRTPEVNPGTAIPSTPEPSHKPAPERPTPSSTPERTSPAPSSSPSSAPSGTPSGTPSGTPSAPTPGTETPTPGTSQTPGASTSPSAPVIPSPSAPVSGTPETGEGKHRKDPSGEPSGSATTAPGTPSADPASPAAPSADDTSEPGTGKHRAEPPRSDDAQRPSRGTEAGRTDLPAAGDYTVRPGDNLSVIAEEHSVAGGWQTIYQKNEKAVGSDPNLIHPGQRLDIRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ68</accession>
    <name>A0A2G1XJ68_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">BLA24_16145</name>
        <name evidence="14" type="ORF">CYQ11_11930</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51276">
        <property type="protein sequence ID" value="PHQ51276"/>
        <property type="gene ID" value="BLA24_16145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13499">
        <property type="protein sequence ID" value="PPT13499"/>
        <property type="gene ID" value="CYQ11_11930"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="552" mass="59621" checksum="6818457F75CBA07F" modified="2018-01-31" version="1">MSGARPVRAPRGTELSTRGWQQEAALRMLQNNLDPEVAEHPDKLVVYGGTGKAARDWRSFDAMVRTLQTLKQDETMLVQSGRPVGVMQTHEWAPRVLIANSNLVGDWANWEEFRRLEALGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAAKKFGGTLAGTITLTAGLGGMGGAQPLAVTMNDGVALCIDCDPRAIERRIEHRYLDVKADSLDHALQLAVEARDARRPLSIGVLGNAAELVPQLLAMNAPIDIVTDQTSAHDPLAYLPLGVSFDDMATYAAENPADFTTRARESMAKHVEAMVGFQDAGAEVFDYGNSIRGEAQLAGYDRAFAFPGFVPAYIRPLFCEGKGPFRWAALSGDPKDIAATDRAILDLFPENESLARWIKMAGERVHFQGLPARICWLGYGERDRAGERFNDMVASGELSAPVVIGRDHLDCGSVASPYRETEAMLDGSDAIADWPLLNAMVNVASGASWVSLHHGGGVGMGRSIHAGQVTVADGTALAGEKIRRVLTNDPGMGVIRHVDAGYDIAESVAAERDVRIPMREQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ82</accession>
    <name>A0A2G1XJ82_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16040</name>
        <name evidence="4" type="ORF">CYQ11_12035</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51260">
        <property type="protein sequence ID" value="PHQ51260"/>
        <property type="gene ID" value="BLA24_16040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13514">
        <property type="protein sequence ID" value="PPT13514"/>
        <property type="gene ID" value="CYQ11_12035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="458" mass="50152" checksum="FB5550603527F854" modified="2018-01-31" version="1">MSTTERPRILVVGGGYVGLYAARRILKKMRYGEATVTVVDPRSYMTYQPFLPEAAAGSISPRHVVVPLRRVLPKAEVLTGRVTTIDQDRKVATIAPLVGEAYELPFDYLVIALGAVSRTFPIPGLAENGIGMKGIEESIGLRNHVLEQLDKADSTKDEEIRRKALTFVFIGGGFAGAETIGEVEDMARDAAKYYPNVKREDMRFILVDAADKILPEVGPKLGEYGKKHLESRGVEIYLSTSMDSCVDGHVVLKNGLEVDSNTIVWTAGVKPNPALARFGLPLGPRGHVDTSETLQVQGTDYIWAAGDNAQVPDMVGRKAGNENAWCPPNAQHALRQAKVLGDNVLSGMRGFPQKTYAHANKGAVAGLGLHKGVAMIVMGKMKIKLKGRLAWYMHRGYHGMAMPTWNRKIRIFADWTLGMFLKREVVSLRAMENPREEFYEAAKPAPQAAAKAEKAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD2</accession>
    <name>A0A2G1XJD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_14450</name>
        <name evidence="6" type="ORF">CYQ11_13625</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51335">
        <property type="protein sequence ID" value="PHQ51335"/>
        <property type="gene ID" value="BLA24_14450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16542">
        <property type="protein sequence ID" value="PPT16542"/>
        <property type="gene ID" value="CYQ11_13625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="223" mass="24069" checksum="89E2736C2EF215D9" modified="2018-01-31" version="1">MEDRVRVVIAEDSVLLREGLTRLLTDRGHEVVAGVGDGEALIKAVGDLASGDALPDVVVADVRMPPTHTDEGVRAAVRLRRDHPELGVLVLSQYVEEQYATELLAGSSRGVGYLLKDRVAEVREFVDAVVRVARGGTALDPEVVAQLLGRSRKQDVLAGLTPREREVLGLMAEGRTNSAIARQLVVSDGAVEKHVSNIFLKLGLSPSDGDHRRVLAVLTYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJG3</accession>
    <name>A0A2G1XJG3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16415</name>
        <name evidence="4" type="ORF">CYQ11_11660</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51321">
        <property type="protein sequence ID" value="PHQ51321"/>
        <property type="gene ID" value="BLA24_16415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13453">
        <property type="protein sequence ID" value="PPT13453"/>
        <property type="gene ID" value="CYQ11_11660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bact-PGI_C" evidence="2">
        <location>
            <begin position="237"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="387" mass="39577" checksum="28FB3FFEAB29885F" modified="2018-01-31" version="1">MFDESLLDNPDGLSRADLHGLLRGAAESGARVRTAVRNAAEAGIGALQPDGRPRAVLVAGPGPAGGSTADLLAALAGDNCPVTLIRPSGVAPAPGALRWALPGWTGPLDLLLVASPDGTEPGLAVLLEQAYRRGCSVVTVTPAGSPLADATAQVRGLAIPLTTTLYETTMASGEQPPEDAPEVLPTGPGTLWSLLTPLLVLADRLGLAETPPSALEALADRLDQIAERCGPAIATYSNPAKTLAAELADTLPLIWTEGELAAAAGRRFATVLAALAGRPALAGELPEALTAHSALLAGDFAAGADPEDFFRDRVEEPEALHARVVLLREREPAVTSPAPAARELALHRDTPVSELEPAEGCGPLETAAELLAITDFAAVYLALASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJH7</accession>
    <name>A0A2G1XJH7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13670</name>
        <name evidence="2" type="ORF">CYQ11_01365</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51385">
        <property type="protein sequence ID" value="PHQ51385"/>
        <property type="gene ID" value="BLA24_13670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11725">
        <property type="protein sequence ID" value="PPT11725"/>
        <property type="gene ID" value="CYQ11_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23383" checksum="86739697B2B8F595" modified="2018-01-31" version="1">MIKPIELVIFDCDGVLVDSEPIAVRIEAEVLAELGWRLTESEIVDRFVGRTTESMRKEIEAHLGRGLPAGWEDEMEARYRAALLAELAPVDGVVAALDALAHLPACIASSGSHDKMRLTLGHTGLFSRFEGRIFSASEVGRGKPAPDLFLHAAERMGVAPDRCVVVEDSQYGVQAARAAGMRAFGYAGGLTPARWLEGPDTIVFDDMLRLPALLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJN5</accession>
    <name>A0A2G1XJN5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13780</name>
        <name evidence="2" type="ORF">CYQ11_01475</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51452">
        <property type="protein sequence ID" value="PHQ51452"/>
        <property type="gene ID" value="BLA24_13780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16283">
        <property type="protein sequence ID" value="PPT16283"/>
        <property type="gene ID" value="CYQ11_01475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23916" checksum="99F91D843E8DFE63" modified="2018-01-31" version="1">MPSTTTPPLFRGDFEAHVTVHASQDDDVRRLERHAADHGLKFTHILLDRGRTPSQPMLTLRRSGPLPQVAAAVEDTVQDLTAAGFTVVRTKIEAAPWAEGVPGTDEAAKALGGRYYFEHHVKLLLDPGTDTTATTALAAAHSAHLSRNARRVRPDGRTERFVTQRCRLVGARTAGARLDALVTALRSGGHTTESVEREFVVHDSDESLDAGWIDEKDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJR8</accession>
    <name>A0A2G1XJR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13425</name>
        <name evidence="3" type="ORF">CYQ11_01145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51504">
        <property type="protein sequence ID" value="PHQ51504"/>
        <property type="gene ID" value="BLA24_13425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11686">
        <property type="protein sequence ID" value="PPT11686"/>
        <property type="gene ID" value="CYQ11_01145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="374" mass="39625" checksum="EDACA8F82A6B40A0" modified="2018-01-31" version="1">MTNAPVNNGLFAPTRLGPLHLSNRLVMAPLTRNRAGADGVPGSLMAEYYAQRASAGLIIAEGTTPNAVGQTYPNIPAIHGAEHIAGWRRVTDAVRAAGGRMFLQLQHGGRVGHPDNSGLTPMAPSPVPLPETIHTPTGRQPSVVPLPMTVQDIHTTVADFAQAARNAVEAGFDGVEVHAANGQLLHQFLAENTNRRTDAYGGPASSRIRFVVEVTRAVAEAIGPERVGLRISPENTVNGIEEGDTEAIYTALLEALADVGLAYLHLEFADPATELFARIRQSWPGTLMANPNLGWPAALPADGGRSAGERLLAAGADLISLGRAFIANPDLVERLEADAPLNRMRDQYTMYVGGPTGYTDYPTLSAERSMALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJU0</accession>
    <name>A0A2G1XJU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_13500</name>
        <name evidence="8" type="ORF">CYQ11_01220</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51518">
        <property type="protein sequence ID" value="PHQ51518"/>
        <property type="gene ID" value="BLA24_13500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11700">
        <property type="protein sequence ID" value="PPT11700"/>
        <property type="gene ID" value="CYQ11_01220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758521" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="765"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="807"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="849"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="891"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="933"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1322"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1380" mass="145619" checksum="A4AED4063624DA7A" modified="2018-01-31" version="1">MRTLVTPCGTASAPCLPTGSRASRRLPWPPFRPPHGGLKSHCSRALRAETIFWGALTDVLEGVASASAVGRGFPGEVSPGPDVRGGDPSVNDRGQAPGDSPAEALPSGPAQAGERLRRRRLERGVSLAKLARLAFYSKGYLSKVENGEKPLTVELARGCDQVLETGGELAQLVLPAVKGNGRRARGAERCPYRGLSPFGAGDAQWFFGRDEAVAEVVSQLAERLRTPGPLLVMAPSGAGKSSLLRAGLLPALARGVLPVTGSQAWPVALLTPGEHPLEELLNRIAVATGASRRLLAKAHEEGGGALATAVCAAVEGMRRAAGPTTAHGKAAYGSATGEAAALVLVVDQFEEAFMLCSDDGERAAFVQALLSLTARREDDGAGLPSALVVLGVRADFYDRCLAFPGLAASLQRGHVTVGPMDDAHVRVAVTRPARAAGLEVEPGLVEILLRDIGLMPGQVAHAGAAPGGALPLLSHALLSTWQHRENATLTVDGYRLTGGVSGAVAATAERAHTSLSARQQAAARRVLLQLIQVGEDRETSRPCRRQDLLEAGTFRPGDPEAVIEAFTRARLLIVDAEHVEIAHEVLLHAWPRLRRWIDDDRAGLRTRQSLAEAAAAWQDEGHDPSLLYRGPRLAAALEALANPQDEADLAPASRRFLEASRALETAEELKEKRRLRRLRVLTSGLTALLVLSLVAGGVAFQQSRAAEHQRHLAVSRELAAQADAVRTDHPQAAALLAVRAFRQAHTAEARSTLLSAYAGYRSADLKAHRSFVNRMAFSPDGHLIATAGADRAVKLWDAATRQMTATLTGHTDAVEDVAFSPDGRILATASDDQSVKLWDLMTRKVTATLTGHNNNVNAVSFSPDGRMLATAGNDRAVRLWDTRSHREIASFTGHTDDVVSVAFSPDGHTLASAGSDRTVRLWDTAEPRGTATLGGHTGTVISVAFSPDGRTLASGGTDRTTRLWDPRSRQLTAVLSGHTDSVYQVAFSPDGHTLATVGFDATARLWDVAGQRQTRSMDGKHKLLGAAFSPDGRFLATTGNTEGDKPDMRVWETSTGRQIAGFGGEVAPATATAFSRRGNLLAVSGRDAAVALYAAYAAEPVKPVATLTTHLGEVAALAFSPDGGTLAVVGAGGSMELWDVAGKRERGTVATQQGGLNAGAFSPDGRTIATAGDDNTVKLWGARTQRVTATLAGHTASVLDVAFSPDGRTLATGSLDRTARLWDTRSGRQNAVLAHGWQVLCVAFSPDGRTVATGDYGRTTLLWDATTHQQTARLTGHSRAVVGVAFSPDGRTLATTSPDRTTFLWDVASRRRSASLTSQADVRAPSFSPDGHTLATGSATGTALLWEIDVNDVVQHVCQESKAQGWARIVPHAAAKGVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJY7</accession>
    <name>A0A2G1XJY7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12705</name>
        <name evidence="3" type="ORF">CYQ11_17060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51558">
        <property type="protein sequence ID" value="PHQ51558"/>
        <property type="gene ID" value="BLA24_12705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14349">
        <property type="protein sequence ID" value="PPT14349"/>
        <property type="gene ID" value="CYQ11_17060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="102" mass="10521" checksum="E13E3463D9F2A4F5" modified="2018-01-31" version="1">MFLAAGKGDINTIIGGIAPNWGPFGQLGREARVMIEVIMAVAILLCLAIAIWGAAKQRIGATALRDTFSAEQGKGLIVAGLTGVFIIGSLGTLFTIVYGMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJZ5</accession>
    <name>A0A2G1XJZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal-sensitive transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12745</name>
        <name evidence="6" type="ORF">CYQ11_17100</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51565">
        <property type="protein sequence ID" value="PHQ51565"/>
        <property type="gene ID" value="BLA24_12745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14356">
        <property type="protein sequence ID" value="PPT14356"/>
        <property type="gene ID" value="CYQ11_17100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="12943" checksum="2AA8E974B14B914A" modified="2018-01-31" version="1">MTTTDGTVTSTTDPATASACDAHSAPGPHGYSKQKDQHLKRLRRIEGQIRGLQRMVDEDVYCIDILTQVSASTKALQSFALQLLQEHLRHCVADAALKGGEEIDAKVAEASAAIARLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKJ2</accession>
    <name>A0A2G1XKJ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11715</name>
        <name evidence="3" type="ORF">CYQ11_02955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51747">
        <property type="protein sequence ID" value="PHQ51747"/>
        <property type="gene ID" value="BLA24_11715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11995">
        <property type="protein sequence ID" value="PPT11995"/>
        <property type="gene ID" value="CYQ11_02955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="868" mass="93492" checksum="FE760D0141630997" modified="2018-01-31" version="1">MLTLKDYDRFCLADPDFYELPERYPDDHDRFPAALRRPPRGWERDESGWRVALRPAGAAPPAQGWRVHVSVTLPHLARAVETVWDHCTGHGLAFDFVRSPGTARETAGEHGDRLAAGRLITVRPADEAALVQALRGLGALLAGLPGPYVLGALRHGDGPLYTEYAATGGRPLRRPDGTAEPHGRRAVFTVPDWLPLPHALRPDLRALHAKPAGHFPYRVERALRLRPGGGTYLAAGPRGAGRVVLREARPHAGVDRWGEDAVARLARERGALERLAGLDCVPRLTDHRRYGEHHYLAREYVEGTSLQAAAALAFPLTSPGRAARESGAYAHWALGVLRRVEQALIALWREGLRLGELHPERVLLRPDGRVVLTGLDSATHRADDRPSPVGEAGFTVPAGRTGADATRWLLDRLRLWLFLPVPHRGPAQLRTLTAEVQRHYPLPPGFGAALLRGLRPPGRVAEEDGGGALFAAERPHWPALRDALVRGIHACATPDRPDRLFPGTPFGRRALGGPAFAHGAAGVLHALHRVGAPVPAPYVTWLVTAATADPGPRPGLYDGLHGVALVLDELGRRQEALALLDRCRAQEDRLVRADLYGGAAGVALTLLRFASLTRDTGLYDRALRLTGALVRLLEDGPPAAGPGDPAPYGLLHGATGVALLFLRWYERTGEARWLERADRALAHDLARLVTLPDQTVALFDGTTHQPYLQGGGAGCALVLRELLVHRPDPARTKLLAALRRSCDPVYVRNAGLLRGRAGAVAVLAALGEGPDGPAVLRQVRRLGWYAQTYRGHLVFPGFRMLRLSSDLATGAAGVLLALGAAFERTGPVLPFLDKARPVAVPPRRGGERRVGDPGTAGVGGGAPRPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKP7</accession>
    <name>A0A2G1XKP7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGA_cap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11990</name>
        <name evidence="5" type="ORF">CYQ11_03230</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51796">
        <property type="protein sequence ID" value="PHQ51796"/>
        <property type="gene ID" value="BLA24_11990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12042">
        <property type="protein sequence ID" value="PPT12042"/>
        <property type="gene ID" value="CYQ11_03230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="37"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="42107" checksum="5B4504817FB85520" modified="2018-01-31" version="1">MAALGLLGGAAAGCSPGAEPRASVPAPSRAAGRGGFTLVATGDVLPHAEVIRQARQDGRRSGTGYDFRPMLAGVQPVVSAADVAICHMETVYGEEKGPFRGYPAFVSPPHVARALKETGYDSCSTASNHTLDAGAKGVRRTLDAMDAVRLRHSGSARSAAEAARVNLLRAGPARVAHLAYTYGTNDVPLPEGRPWTVNLIDRGRIVADARAARKAGADVVVVSLHWGTEWQPEPDEQQLTLARRLTAAATGGRPDVDLIIGTHNHVPQAYEKVNGTWVVYGMGDQLAGRMFNPEGAPDERGNQSSLARFSFAPPARRGGRWTVTKAEFVPQLTDLARGFRVLDLSRAAGEQPGRERLSAARDRIREAVLSRGAGKDGLVMTGEPAAHGAGRSGAARATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKZ3</accession>
    <name>A0A2G1XKZ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000132">
        <property type="protein sequence ID" value="PHQ51897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51897">
        <property type="protein sequence ID" value="PHQ51897"/>
        <property type="gene ID" value="BLA24_11055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="65" mass="7083" checksum="D12F567DE975C12A" modified="2018-01-31" version="1" fragment="single">MADTHVLFVEDDDVIREATQLALERDGFMVTAVPDGLLGLESFRARRPDIALLDVMVPGLDGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLF3</accession>
    <name>A0A2G1XLF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09125</name>
        <name evidence="3" type="ORF">CYQ11_27735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52078">
        <property type="protein sequence ID" value="PHQ52078"/>
        <property type="gene ID" value="BLA24_09125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16158">
        <property type="protein sequence ID" value="PPT16158"/>
        <property type="gene ID" value="CYQ11_27735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="142" mass="15457" checksum="83D56F7A122D5D3E" modified="2018-01-31" version="1">MADHQEASVTLPSAPASVRAARCHVMDVLAGWGLPDGGEAADALRLIVSELATNAVQHTRGQSPTFRVDLRLDREERLRIGVTDRHPRHPRRLPATVQQDHGRGLVIIRCLTAEHGGRLSVVPTAEGGKTVWVSLPWSVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLZ5</accession>
    <name>A0A2G1XLZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52275">
        <property type="protein sequence ID" value="PHQ52275"/>
        <property type="gene ID" value="BLA24_08960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="241" mass="25199" checksum="2597A143B619E133" modified="2018-01-31" version="1">MLLVLALSLGASAVSSLISFIGSLTRPGGLKHQAATLNASHAPGRPWLDLAWQVFGIATALVPVLLVAHLLTREGAGMRSIGFDRTRPGPDVARGALVAAAIGGTGLLFYLAARAAGFNLTVVPENLPDVWWRIPVLIGSAVQNAVLEEVVVVGYLLRRLGQLGWTPTAALAASALLRGSYHLYQGVGGLIGNMVMGVVFVLLYRRWGRVGPLVAAHALIDTVAFVGYALLAGKVGWLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM03</accession>
    <name>A0A2G1XM03_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="7">5.4.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mutA</name>
        <name evidence="13" type="ORF">BLA24_08740</name>
        <name evidence="14" type="ORF">CYQ11_04000</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52240">
        <property type="protein sequence ID" value="PHQ52240"/>
        <property type="gene ID" value="BLA24_08740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12173">
        <property type="protein sequence ID" value="PPT12173"/>
        <property type="gene ID" value="CYQ11_04000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019652">
        <property type="term" value="P:lactate fermentation to propionate and acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024067">
        <property type="entry name" value="Me-malonyl-CoA_mutase_sm_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004608">
        <property type="entry name" value="MMCoA_mutase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00642">
        <property type="entry name" value="mmCoA_mut_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="12">
        <location>
            <begin position="53"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ52240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="631" mass="65439" checksum="3AB6AB0617465388" modified="2018-01-31" version="1">MTVLPENGFSLAAEFPDATREQWQRLVEGVLSKAGTVAEGPAAEDALATALQDGLATRPLYTADDAPAVPGFPGLPPFVRGGRAEGTAVTGWDVRQRHAGPDPRRANEAVLADLENGVTSLWLTVGASGLPVDGIPPALDGVYLDLAPVVLDAGADFEAAARRLLSLHDERAVPRTAARGNLGADPLGTWARTGGDSDPAGALDAATGLAALCARTYPGIRALTVDALPYHEAGGSAAQELGCSLATGVAYLRALTAAGLTVDEACAQLEFRYAATADQFLTIATLRAARRLWARVAEVSGATPAARAQRQHAVTSTVMMTRRDPWVNILRTTIACLGAGVGGADAVTVLPFDEALGLPDAFARRVARNTSSILLEESHLARVIDPAGGSWYVERLTDELAHTAWAWFQEIERAGGQAAALRSGLVAERLARTWQERSARLATRREPVTGVSEFPHLGEQAVSRESAPAAPAPGPGALPRVRRDEAYEALRARSDAHLAATGARPRVFLAALGPAAAHTGRVTFAANLFQAGGVEPVHEPGPVDAGTVAEAFARSGATVACLCSSDKLYAEQAEAVAEALAAAGAARIFLAGRPGGEQREAYLRAGVDEFVFAGGDAVAVLSSVLDSLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMA3</accession>
    <name>A0A2G1XMA3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">BLA24_07790</name>
        <name evidence="6" type="ORF">CYQ11_00220</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52346">
        <property type="protein sequence ID" value="PHQ52346"/>
        <property type="gene ID" value="BLA24_07790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11549">
        <property type="protein sequence ID" value="PPT11549"/>
        <property type="gene ID" value="CYQ11_00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="54" mass="6456" checksum="F955CCC113757E3F" modified="2018-01-31" version="1">MARNEIRPVIKLRSTAGTGFTYVTRKNRRNDPDRLVLRKYDPVVGRHVDFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMQ6</accession>
    <name>A0A2G1XMQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Amino acid:proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_06485</name>
        <name evidence="7" type="ORF">CYQ11_26635</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52429">
        <property type="protein sequence ID" value="PHQ52429"/>
        <property type="gene ID" value="BLA24_06485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15961">
        <property type="protein sequence ID" value="PPT15961"/>
        <property type="gene ID" value="CYQ11_26635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="549" mass="57093" checksum="EB98A90004D7F2E6" modified="2018-01-31" version="1">MDVGAANRKGLSLFALIMIGLGSIFGSGWLFGAGQAARVAGPASLVAWVIGAVFIGMIAMSYAEAGAAYPLPGAMARFGSLSHGPVLGFVTGWAVWIATASLIPIEAIAGTQYMSSWNFGWARGLVTDGSLSGTGLATALFLTCALWLACYWSVALLARANNLLTLVKFAIPVLAVAALIASGFHTGNFTDHGGFAPNGWSAVLTAVSASGVVFAFNGFQAVVNLGGAAKDPGRAIPRALVGALSLGLLIYLALQVAFLGAVPPERLTEAGGWNGIDFASPFADLAKLLMLHWVVTMLQFGAFISPNGANIGNVASAAYLAQNLAETGFFPKKIAEVHPRYGVARPAMWLNLGFSVLLLLTIGHSWEALASVVSAAMVVSYLMGPIAVGVFRRTKPDLPRPFRLPAATVLCPLTFAFAACALYWSKWPNTGKVALLTLVSVPVAAVVLRRRGEKSLRRQFAPAWWMVAFLMWMALLSALGSTEFGGHGVIPGGVDTALVALSSLGFYFWAVRAGVRAHEAGLPGPDPVLGATGTAVPAPRSPEPVAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR9</accession>
    <name>A0A2G1XMR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06990</name>
        <name evidence="3" type="ORF">CYQ11_27145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52516">
        <property type="protein sequence ID" value="PHQ52516"/>
        <property type="gene ID" value="BLA24_06990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16052">
        <property type="protein sequence ID" value="PPT16052"/>
        <property type="gene ID" value="CYQ11_27145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304792" evidence="1">
        <location>
            <begin position="25"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20217" checksum="7003CC886E351B7C" modified="2018-01-31" version="1">MRARRAAGALALCGALVAGLSACGIEPTEVVEVGRPAQGVKRPGEPVKEARLYFAFPGLAGGLQPVSRPAREGVSAEEAVLLLLHGPNEAERMRGLFSEVPKSGGRIEVGTAQGRVTIQLPLDVARLTVTARRQLVCTAAHNRVPGGLPPERIEVDLVGGGRKVTGQTCENSYVVPMVDHLPTPARTPAPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT3</accession>
    <name>A0A2G1XMT3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07015</name>
        <name evidence="2" type="ORF">CYQ11_27170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52520">
        <property type="protein sequence ID" value="PHQ52520"/>
        <property type="gene ID" value="BLA24_07015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16056">
        <property type="protein sequence ID" value="PPT16056"/>
        <property type="gene ID" value="CYQ11_27170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="30485" checksum="E58BF9083282CB76" modified="2018-01-31" version="1">MSTDPVVRYERRGPVATVTMNRPRYRNAQNLDMTYALDGAFYAASDDDAVKVVVLAGAGDHFSAGHDIGTAERGADLPHPRRAGLWWDHSDKAGAERRFARESEVYLGMCRRWRELPKPLIASVQGACVAGGLTLAWVCDLIVASEDAFFADPVVRMGVPGVEYFAHPWVMPPRVAKELLYTGDRMSARRAYEVGMVNRVVPRAELAGRTAELAERVARMPRMGLALAKRAVNQAEDLQGLHAGLDSVFGLHHLAHAHNAETSRDPLGGMDVRAMKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT6</accession>
    <name>A0A2G1XMT6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_06650</name>
        <name evidence="8" type="ORF">CYQ11_26800</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52459">
        <property type="protein sequence ID" value="PHQ52459"/>
        <property type="gene ID" value="BLA24_06650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15991">
        <property type="protein sequence ID" value="PPT15991"/>
        <property type="gene ID" value="CYQ11_26800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758516" evidence="5">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="7598" checksum="A9DD37FB4E4A0C51" modified="2018-01-31" version="1">MSRIAKAAVLTAAVGTVVSGVAGVASADSGAQGAAVGSPGVVSGNVIQIPLHVPINLCGNTIDIIALLNPTFGNTCVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN90</accession>
    <name>A0A2G1XN90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07040</name>
        <name evidence="3" type="ORF">CYQ11_27195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52619">
        <property type="protein sequence ID" value="PHQ52619"/>
        <property type="gene ID" value="BLA24_07040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16829">
        <property type="protein sequence ID" value="PPT16829"/>
        <property type="gene ID" value="CYQ11_27195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="351" mass="36047" checksum="8E150697F3C21E43" modified="2018-01-31" version="1">MPTALTRLVGVRHPVVQAGMGWVAGPRLVTAVAEAGGLGVLGSATMTPPQLRAAVREVRSRTDRPFGVNLRADAGDAAERVEIMVAEGVRVASFALAPSRALIARLKDAGIVVIPSVGARRHAEKVVAWGADAVLVQGGEGGGHTGGVATTVLLPQVVDAVGVPVVAAGGFHDGRGLVAALAYGACGVAMGTRFLLTADSTVPAAVKAAYLAATVRDVTVTTKVDGLPHRMLRTPFVDGLERAGRAATALRALRHAAAFRELSGAGRLRLLRDGLALRRARDLTWSQVLLAASTPVLLRAAMVDGRTDLGVMAAGQVAGVIDDLPSCAELIERIMAEAQAALRGLGLHEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNI9</accession>
    <name>A0A2G1XNI9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05350</name>
        <name evidence="5" type="ORF">CYQ11_01810</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52812">
        <property type="protein sequence ID" value="PHQ52812"/>
        <property type="gene ID" value="BLA24_05350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16291">
        <property type="protein sequence ID" value="PPT16291"/>
        <property type="gene ID" value="CYQ11_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="410" mass="42471" checksum="C9E0E02B182A0B89" modified="2018-01-31" version="1">MTQPYGALSAIAAATVLLWVLAGWPRSTERLGGPLALAGVLSLAVTVGAEPPTTTGESWVRLVEVAVLLVLLVVAARWVPPPRAVAAGAPAATAVATWSLPLMPAPSVLTLAGAAAFWSLPVLGAVVVGGYPRLMEHRRRRLVVETRRSQQLELARDLHDFVAHDVSGIVAQAQAARFVAETDPARALPALERIEAAGLNALASMDRMVKTLHEADGADARPVGTGGVEPLPGVDQLPGLVARFSSADLSQTARLGVAAGATDGLSRTAGSTAYRTVVEALTNVRRHAPGASRVDVALTRVRTTDGASALEVSVVDDGGAGKRAGTRTALRREREGHGGRGLNGLRERVRAAGGTLVYGPHGDGWRVTAVLPLTPEPLSQEPPTPEPPAPEPLPSGPKRTTSPALTEQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNK1</accession>
    <name>A0A2G1XNK1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_05710</name>
        <name evidence="8" type="ORF">CYQ11_02185</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52761">
        <property type="protein sequence ID" value="PHQ52761"/>
        <property type="gene ID" value="BLA24_05710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11862">
        <property type="protein sequence ID" value="PPT11862"/>
        <property type="gene ID" value="CYQ11_02185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="646"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="683" mass="73041" checksum="2EB410D35E01030A" modified="2018-01-31" version="1">MIDVTGFLKRLALGRAMRSEELNETLLPKRLALPIFASDPLSSVAYATQEILLVLTLGGMAYLHFTPWIAAAVVALMTVVVLSYRQVVHAYPSGGGSYEVASTNLGASAGLVVAASLLVDYVMTVAVSVASGVDNIISAVPELSGYRVVMAIGFVVLLTGANLRGVRESGQAFAAPTYLFIAGVLIMVATGLLRYLLGHPPVSESAGLGIAADPADADLAGLALVMLGLRAFSSGCTALTGVEAISNGVPAFRKPKSKNAAATMSVMGVIAVTMFVGVTTLALVAKVHIAGDSCRLTGLPGDCAAYTQRTVIAQLASAVFGGEHSFGFYFVQAATALVLVLAANTAFNGFPLLASILAQHRYLPRQLHNRGDRLAFSNGIIALALAAGLLLWFYKADVTSLIHLYILGVFTSFTLSQTGMVRHWNRALRGESDPAVRRRGLTARVINATGAVVTGLVLVIVLATKFLEGAWLAVVAAVVLWTTMRGIRRHYDSVSAELAVTDPRAELVRPSRVVAVLLVSTIHKPTLRALAYARALRPDLLEALTVAVDRDETKALERQWEELDVDVPLRVVASPYREITRPVVEYVRSIRRAGPRDVVSVFIPEYVVGHWWEHLLHNQSALWLKSRLLFTPGVMVTSVPWQLTSSSRADHPARRAPGAIRRGEPAPAHLHHHRPPSGNGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNS5</accession>
    <name>A0A2G1XNS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04830</name>
        <name evidence="3" type="ORF">CYQ11_28700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52892">
        <property type="protein sequence ID" value="PHQ52892"/>
        <property type="gene ID" value="BLA24_04830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11449">
        <property type="protein sequence ID" value="PPT11449"/>
        <property type="gene ID" value="CYQ11_28700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="24232" checksum="0E2890C93B6731A1" modified="2018-01-31" version="1">MSTAALITILVATAVVLVGVAVAVRLVGRGAAPGGRGLRRRFGPEYDTAVARHDGDDKAAEKELHERWRRHKDVRICPLPAAVREQYAARWTGVQEEFVDAPARAVADADLLLGTIAHERGFPTGSWDELIDALSVHHPRTVHGIREVHAASARVRVERVPTEELREALVGARDLFEDLVRAHPEDQPPQRHARRTGPRPEKPVTRTAGPRHAHDGVPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNX5</accession>
    <name>A0A2G1XNX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05155</name>
        <name evidence="2" type="ORF">CYQ11_28375</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52938">
        <property type="protein sequence ID" value="PHQ52938"/>
        <property type="gene ID" value="BLA24_05155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11400">
        <property type="protein sequence ID" value="PPT11400"/>
        <property type="gene ID" value="CYQ11_28375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="6811" checksum="54EE82BFA79168EB" modified="2018-01-31" version="1">MPGTGRRPAGRYGIHVQAVDPPGAPAGAAHLRLTPSAAHRIVDVYRLARVLRQAWDELGLSTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNX9</accession>
    <name>A0A2G1XNX9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05190</name>
        <name evidence="4" type="ORF">CYQ11_28340</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52944">
        <property type="protein sequence ID" value="PHQ52944"/>
        <property type="gene ID" value="BLA24_05190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11394">
        <property type="protein sequence ID" value="PPT11394"/>
        <property type="gene ID" value="CYQ11_28340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="411" mass="44126" checksum="09FDBC1F3EBC11CC" modified="2018-01-31" version="1">MPEPLNPADPAFARDPYPAYARLREQAPVARVALANGTHAWLVTGHEQARAVLADPRFSNVPAPGAGRPKPDSPAQRARGCLARHMLNSDAPDHLRLRRLTTAAFTPRRVDALRPRIERLTDGLLAGLSARLELDGGADLVDAFAFPLPVLVIGEVLGVPEADRAELREWTYRVGSPADALVEGAVDEAWVRLHAYFSALIARKRRAPGEDLFSALVHDASEGGLDDGELLAMAFLLLFAGYETTMNLLASASLSLLEHPAELAAAREGGPERWAAVVEEVLRHASPLEGTTWRRTTAAVDLGGEGVIPAGDSVLVVLAAANRDPAHFPEPDAFRPDRHLTGADRAAPHLAFGHGPHFCLGARLARLEAAVALPRLFAAFPGLALAADPQRLPYRPGLLVRGPRRLPVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP29</accession>
    <name>A0A2G1XP29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04720</name>
        <name evidence="2" type="ORF">CYQ11_28815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52970">
        <property type="protein sequence ID" value="PHQ52970"/>
        <property type="gene ID" value="BLA24_04720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11516">
        <property type="protein sequence ID" value="PPT11516"/>
        <property type="gene ID" value="CYQ11_28815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="111" mass="12579" checksum="2B970C569F1F2DBE" modified="2018-01-31" version="1">MINADDVRRIALSLPETVEKEAWDIPTFRVAGKMFITVPDDGTSFAVRCPRHERAELIAAEPEKFWVPPHEAASAWVRVRLAALEDLDELRDILVDSWRQAAPERLTDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP64</accession>
    <name>A0A2G1XP64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05220</name>
        <name evidence="4" type="ORF">CYQ11_28310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52949">
        <property type="protein sequence ID" value="PHQ52949"/>
        <property type="gene ID" value="BLA24_05220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11389">
        <property type="protein sequence ID" value="PPT11389"/>
        <property type="gene ID" value="CYQ11_28310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758520" evidence="2">
        <location>
            <begin position="28"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="329" mass="34200" checksum="DED6425D8779B1B4" modified="2018-01-31" version="1">MRRPRRTTAGILLIAGALVTAGTQATAAAGAPPAPGTVHTLAASAAARQKASDYWTPDRMRTATPLDLLPVAPDAASAAPERGGRTTTVAPTAPAAPRTRSFPQAGAPWTGGGAVVRTSGRVFFTMQGRNASCSGDAVTSKNGSTVITAGHCVKYQGAWHTNWVFAPGYDNGQTPYGKWTASKTMSTPQWVANEQTGMNYDVGAAVVAPVDGKRLTDVVGAQGLEFNGGYNKAMYSFGFPAASPYDGTKLIHCSGKSSKDFLLTTDHGLGCNMTGGSSGGPWFTSFDEASGTGLQASVNSFGYVFLPNTMFGPYFGDDVKKLYDQAQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP77</accession>
    <name>A0A2G1XP77_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_04195</name>
        <name evidence="14" type="ORF">CYQ11_14065</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53026">
        <property type="protein sequence ID" value="PHQ53026"/>
        <property type="gene ID" value="BLA24_04195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13866">
        <property type="protein sequence ID" value="PPT13866"/>
        <property type="gene ID" value="CYQ11_14065"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="35474" checksum="B5C72C5CEE02DF76" modified="2018-01-31" version="1">MSTTYGTFPGARPRRLRTSPAMRRMVAETRLHPADLILPAFVREGISEPVPISAMPGVVQHTRETLRKAAVEALDAGVAGIMLFGVPEDAKKDGLGTAGTDPDGILQVAIRDVRDEVGDELVIMSDLCLDEFTDHGHCGVLDSAGRVDNDATLERYAEMAQVQADAGVHVVGPSGMMDGQVGVIRDALDQTGHEDVSVLAYTVKYASAFYGPFREAIGSSLQGDRKTYQQDPANVRESLRELSLDLAEGADMVMVKPALPYLDILAKVAEAVDVPVAAYQISGEYAMVEAAAANGWIDRDRAIMESLTGIKRAGANMILTYWATEVARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPS1</accession>
    <name>A0A2G1XPS1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA cytosine-C5-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_02660</name>
        <name evidence="9" type="ORF">CYQ11_04955</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53234">
        <property type="protein sequence ID" value="PHQ53234"/>
        <property type="gene ID" value="BLA24_02660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12326">
        <property type="protein sequence ID" value="PPT12326"/>
        <property type="gene ID" value="CYQ11_04955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="7">
        <location>
            <begin position="184"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="290"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="51325" checksum="7F16D7F12106E7CF" modified="2018-01-31" version="1">MNDQASRRRPAKPYRRPKKDPVRILAFEALRAVDERDAYANLVLPPLLRKAREKDGFEARDAALATELVYGTLRRQGTYDAVIAACVDRPLREVDPPVLDVLSLGAHQLLGTRIPSHAAVSASVELARVVLGDGRAKFVNAVLRKIAAHDLDGWLEKVAPPYEDDPEEHLAVFHSHPRWIVSALWDALGGGRAGIEDLLEADNERPEVTLVARPGRATTDELLAALGEDSGLPGRWSPYAVRLAEGGEPGALDAVREGRAGVQDEGSQLVALALADVPLDGPDERWLDGCAGPGGKAALLGALAAQRGAALLASEKQPHRARLVERALAGNPGPYQVIAADGTRPPWREGSFDRVLVDVPCTGLGALRRRPEARWRRRPEDVAGFATLQRDLLREALRAVRVGGVVGYATCSPHPAETKAVVDDVLKRDGVSAEWIDARPHMQGVPALGEGPDVQLWPHLHGTDAMYLALLRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPY8</accession>
    <name>A0A2G1XPY8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02915</name>
        <name evidence="2" type="ORF">CYQ11_05210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53280">
        <property type="protein sequence ID" value="PHQ53280"/>
        <property type="gene ID" value="BLA24_02915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12375">
        <property type="protein sequence ID" value="PPT12375"/>
        <property type="gene ID" value="CYQ11_05210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="180" mass="20014" checksum="CE58A8DB39C2DAB4" modified="2018-01-31" version="1">MTTLIWIAAALVLIGIYLSWTAGRLDRLHSRIDAARAALDAQLLRRASVAQELATAGVLDPAASIVLYQAAHAARQAEEEHREVAESELSQALRAVFAETPQVEEVRQAPGGEESLEELTQAVRRVPMARRFHNDSVRAARALRRHRKVRWFRLAGHAPFPLAFEMDDEPPLALGDRNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ07</accession>
    <name>A0A2G1XQ07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02045</name>
        <name evidence="3" type="ORF">CYQ11_04405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53328">
        <property type="protein sequence ID" value="PHQ53328"/>
        <property type="gene ID" value="BLA24_02045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16347">
        <property type="protein sequence ID" value="PPT16347"/>
        <property type="gene ID" value="CYQ11_04405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="14925" checksum="30349F9B10192577" modified="2018-01-31" version="1">MTAPTSPRIDQHPDILALRAHSEETTATPAAQGLEALAVLCGVYLAASPWIVGFNGFSTLTANNLITGIAFACLVGGFGSAYERTHAMSWAALCLAAWTIMAPWIVSGHAFITAANVSNVVVGIVSCVVALALAGLGFGRRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ88</accession>
    <name>A0A2G1XQ88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_01300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000018">
        <property type="protein sequence ID" value="PHQ53404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53404">
        <property type="protein sequence ID" value="PHQ53404"/>
        <property type="gene ID" value="BLA24_01300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="65" mass="6980" checksum="1E9FC93C8E30276D" modified="2018-01-31" version="1">MKAVRELGLERRETVRSLSAVRVGVLRRAVPSTRGPGRTNLWCASCPAKGMAGWLRSGGITAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQB4</accession>
    <name>A0A2G1XQB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_00390</name>
        <name evidence="5" type="ORF">CYQ11_07400</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53428">
        <property type="protein sequence ID" value="PHQ53428"/>
        <property type="gene ID" value="BLA24_00390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12732">
        <property type="protein sequence ID" value="PPT12732"/>
        <property type="gene ID" value="CYQ11_07400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304951" evidence="3">
        <location>
            <begin position="30"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="242" mass="24740" checksum="7112B26E962D6231" modified="2018-01-31" version="1">MSVKSRLAAATVLTAAVAAVAYPTAGAFAADTAHRDTRPGTPATSHQVQLPDGSRARLTSGRSGTTVTVTSARGHHTLDAGRPSADLDRLHLRIIGGDTTHPTLRARLDGTRLTNYYDFASGSLRHTADGSDLDRPVREGDSIADYRKESPAGPAATAVPAQPRPHGAPASAQPHASAKGKPPHDSSGNPVKRVVEAGQVIKASHDVGDVGTPVLAAGVALLAVGGAYGVRVALRRGGRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQC3</accession>
    <name>A0A2G1XQC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01210</name>
        <name evidence="1" type="ORF">BLA24_27250</name>
        <name evidence="3" type="ORF">CYQ11_18405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000015">
        <property type="protein sequence ID" value="PHQ53410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48924">
        <property type="protein sequence ID" value="PHQ48924"/>
        <property type="gene ID" value="BLA24_27250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53410">
        <property type="protein sequence ID" value="PHQ53410"/>
        <property type="gene ID" value="BLA24_01210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16650">
        <property type="protein sequence ID" value="PPT16650"/>
        <property type="gene ID" value="CYQ11_18405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="409" mass="43158" checksum="5B7D4AB36F01A2ED" modified="2018-01-31" version="1">MALASAGPGLASAGSGVVSPCADPVAERLRRWRLVLGGEADGGDGTGCALAGSDAAMDRTLEALYGSGGAAAPGRREAGLGGSAPRVARWLGDIRTYFPASVVQVMQRDAIDRLGLSALLLEPEMLEAVEADVHLVGTLLSLNRAMPEATKETARAVVRKVVQDLEKRLANRTRATLSGALDRSARVSRPRHADIDWNRTIRANLKNYLPDHRTVVPERLIGYGRAARSVKKEVILCIDQSGSMAASVVYASVFGAVLASMRTLDTRLVVFDTAIVDLTDQLTDPVDVLFGTQLGGGTDINRALAYCQSRITRPAETVVVLISDLYEGGIRNEMLKRVAAMKASGVQFVTLLALSDEGAPAYDRDHAAALAALGAPAFACTPDLFPDVMAAALEKRPLPVPEPIPGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQG4</accession>
    <name>A0A2G1XQG4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">BLA24_00715</name>
        <name evidence="8" type="ORF">CYQ11_07725</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53487">
        <property type="protein sequence ID" value="PHQ53487"/>
        <property type="gene ID" value="BLA24_00715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12792">
        <property type="protein sequence ID" value="PPT12792"/>
        <property type="gene ID" value="CYQ11_07725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="202" mass="22469" checksum="A799B3E6BBF6D269" modified="2018-01-31" version="1">MAGAMRKMAVYLGLVEDDGYDGPGFDPDDEFEPEPEPDRRRQHQSHQAQQTQSDEPVRVAQPPAQREPAPLVAETGRPARIAPVSSITPERHSLEKNAPVIMPKVVSEREPYRITTLHPRTYNEARTIGEHFREGTPVIMNLTEMDDTDAKRLVDFAAGLVFGLHGSIERVTQKVFLLSPANVDVTAEDKARIAEGGFFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQP2</accession>
    <name>A0A2G1XQP2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metF</name>
        <name evidence="11" type="ORF">BLA24_00845</name>
        <name evidence="12" type="ORF">CYQ11_07855</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53511">
        <property type="protein sequence ID" value="PHQ53511"/>
        <property type="gene ID" value="BLA24_00845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12816">
        <property type="protein sequence ID" value="PPT12816"/>
        <property type="gene ID" value="CYQ11_07855"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="305" mass="33565" checksum="245F3541947DFDB9" modified="2018-01-31" version="1">MALGTASTRTDHALTVRELLASGERSYSFEFAAPKTEKGERTLWNAIRRIEAVGPTFVSVTYGAGGSSREGTVRATERIATDTTLTPVAHLTAVDHSLAELRNVIGQYADVGIRNMLALRGDPPGDPMGEWVRHPEGVRYAADLVRLIKESGDFCVGVAAFPEMHPRSTDWETDIGHFVDKCRAGADFAITQMFFYPEDYLRLRDRVAAAGCETPIIPEIMPVTNVRQIERFAQLSNAAFPPDLAERILAVKDDSAAVRSVGIEYATDLCARLMAEEIPGFHFITLNHSTATLEIYENLGLHQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X983</accession>
    <name>A0A2G1X983_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30215</name>
        <name evidence="3" type="ORF">CYQ11_23305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_071965196.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47790">
        <property type="protein sequence ID" value="PHQ47790"/>
        <property type="gene ID" value="BLA24_30215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15415">
        <property type="protein sequence ID" value="PPT15415"/>
        <property type="gene ID" value="CYQ11_23305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13741" checksum="BC6C1C268B84E377" modified="2018-01-31" version="1">MILLRRLLGDVLRRQRQRQGRTLREVSSSARVSLGYLSEVERGQKEASSELLSAICDALDVRMSEVMREVSDELSLAELAQSAAASEPVPAPMRPMFNSMSVTSVTGVPGERVTIKAPAEAVDVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X994</accession>
    <name>A0A2G1X994_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30270</name>
        <name evidence="3" type="ORF">CYQ11_23365</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47800">
        <property type="protein sequence ID" value="PHQ47800"/>
        <property type="gene ID" value="BLA24_30270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15425">
        <property type="protein sequence ID" value="PPT15425"/>
        <property type="gene ID" value="CYQ11_23365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="14394" checksum="844DFB9583959B6D" modified="2018-01-31" version="1">MRIEELLTAARAGLDRLSPAGAAAAQADGGLLVDIRYAALRERDGTIPGALVVERNELEWRLDPACDHRAAQATSHGLWVIVLCDEGYASSLAAVSLHRLGLHRATDVVGGFQAWRAAGLPVLSPGAGAAGAAGPGRGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9E9</accession>
    <name>A0A2G1X9E9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_30500</name>
        <name evidence="7" type="ORF">CYQ11_23595</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47846">
        <property type="protein sequence ID" value="PHQ47846"/>
        <property type="gene ID" value="BLA24_30500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15471">
        <property type="protein sequence ID" value="PPT15471"/>
        <property type="gene ID" value="CYQ11_23595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="479"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ47846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="706" mass="77379" checksum="01731E1BA63B6686" modified="2018-01-31" version="1">MTADTSVPSTALLTGADRDGSNYTARHLLVLEGLEAVRKRPGMYIGSTDSRGLMHCLWEIIDNSVDEALGGFCDHIEVILHEDGSVEVRDNGRGIPVDVEPKTGLSGVEVVMTKLHAGGKFGGGSYAASGGLHGVGASVVNALSARLDVEVDRNSRTHAISFRRGVPGIFTESGPDAPFDPANGLLKGKKVPKARTGTRVRYWADRQIFLKDAKLSLETLYGRARQTAFLVPGLTIVVRDERELDGQAVTEETFRYDGGISEFCEYLAQDKAVCDVLRLSGQGTFKETVPVLDDRGHMTPTEVTRELGVDIALRWGTGYDATVKSFVNIIATPKGGTHVTGFERSITKTVNEVLRSSKLLRVAEDDVVKDDAMEGLTAVVTVRLAEPQFEGQTKEVLGTSAASRIVANVVAKELKAFLTSTKRDAKQQARAVLEKVVAAARTRIAARQHKEAQRRKTALESSSLPAKLADCRSDEVERSELFIVEGDSALGTAKLARNSEFQALLPIRGKILNVQKASVSDMLKNAECGAIIQVIGAGSGRTFDIDAARYGKVIFLADADVDGAHIRILLLTLFQRYMRPMVEEGRVFSAVPPLHRVELTHPKKGQDKYIYTYSDNELRQTLLELERKNIRYKEGIQRYKGLGEMDADQLAETTMDPRHRTLRRINISDLEAAERTFDLLMGNEVAPRKEFITNSAATLDRSRIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9R6</accession>
    <name>A0A2G1X9R6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31350</name>
        <name evidence="3" type="ORF">CYQ11_24390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47961">
        <property type="protein sequence ID" value="PHQ47961"/>
        <property type="gene ID" value="BLA24_31350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15585">
        <property type="protein sequence ID" value="PPT15585"/>
        <property type="gene ID" value="CYQ11_24390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="28754" checksum="B9E5514C02539FD9" modified="2018-01-31" version="1">MATHFSGGGHADGYTALDSFPYEALALLLAPAALFVALGYAMRTARTRALTALACGLAGTLGCVSTSVVLVNAHASTAAEARLPLGHLGLALAVGAAAAGLGLLLAGRDTPSAAPAPAGAGAPRLDLGDGESATWTRVAGSRPLRVVGAVSGVLGVLLAALVGWGAGLGLLATTVLLLPMSTVRVTVDRHGLTACLPWLPRPRLRIPLARVASAQARHVDPWKDLGGWGYRVVPGRSGLALRSGEAIVVALTTGSEFVVTVDDAATAAALLNALADRHRAHGGSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9T2</accession>
    <name>A0A2G1X9T2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ngcE</name>
        <name evidence="3" type="ORF">BLA24_31415</name>
        <name evidence="4" type="ORF">CYQ11_24455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47971">
        <property type="protein sequence ID" value="PHQ47971"/>
        <property type="gene ID" value="BLA24_31415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15596">
        <property type="protein sequence ID" value="PPT15596"/>
        <property type="gene ID" value="CYQ11_24455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022386">
        <property type="entry name" value="Chitin_NgcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03851">
        <property type="entry name" value="chitin_NgcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304798" evidence="2">
        <location>
            <begin position="35"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="481" mass="52541" checksum="C6028FFADA8273CD" modified="2018-01-31" version="1">MGSTSEFSRRDLIKRAAALGLIAVPTMSALSACAAGGDDDDDKKTDSGGKGQKDAEMKPLNVDGSAPLDVVIFDGGFGQQYAKDAEAEYKKAYPKAEIKHSGTQDIGPQVQPRFNGGTPPDLIDNSGAKQMDLGTLVGLKQLTDLNALLDAPSLDDPKKKVRDTLRPGVVEMGQFDGEQVWVLYYAYTVYGIWYSKTNLQKLDEQYPQTWDDMLKVCEKAKKKGVAGWTYAGQHPYYLPFSLYPFIAKIGGADVLKRIDNLEPDSWKDPAVKAAFEAYYELYKKGYVLQGTPGLDHIQSQTAWNQGKALFIPNGSWVENESKKMTPADFQMAVGAPPSLDKSDKMPFGTLWASGGEPFIVPKSAKNPQGGMELLRVMLGKKSTQNFIKAVSSLTSLNGGTEGLSLPPGLASSQEALTKAGGNVVNPRLQDWYVTLQKEKIGKGALGEMMAGRLTPDETIKKIQKYVDDTRKDDSVKKYKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9U3</accession>
    <name>A0A2G1X9U3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">BLA24_31685</name>
        <name evidence="17" type="ORF">CYQ11_24740</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48017">
        <property type="protein sequence ID" value="PHQ48017"/>
        <property type="gene ID" value="BLA24_31685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15643">
        <property type="protein sequence ID" value="PPT15643"/>
        <property type="gene ID" value="CYQ11_24740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="5"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="352"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ48017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT15643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="471" mass="48862" checksum="B76A8A67767535F6" modified="2018-01-31" version="1">MHETDVIVIGGGTGGYSTALRAAALGLEVVLAERDLVGGTCLHRGCIPSKAMLHAAELVDGIAEARERWGVKASLDSVDWAALTATRDDIVSRNHRGVEGHLSHAGVRVVRGSATLTGPRTVRVETGAEAGTAWRARRGIVLATGSRPRTLPGLQPDGARVVTSDDALFAPGLPGSVLVLGGGAIGVEYASLHRSMGAEVTLVEAADRLLPLEDAEVSRHLTRGLKKRGIDVQTSARLEEATPHEDGVRATLRTARGEVREVRADRLLVAVGRVPVTDGLGLAAAGLATDARGFVAPADWSRLETAVPGVHVVGDLLPPPSLGLAHASFAEGLVVAEALAGLTPRPVDYTAVPRVTYSSPQTAAVGLSEAEARERGHDVLVNSMPLTAVAKGMVHGRGGVVKVVAERDGGRVLGVHLVGPHVSEMIAESQLVVGWDAEAADVAQHVHAHPTLSEAVGEVMLSLAGRGLHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Z5</accession>
    <name>A0A2G1X9Z5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_31530</name>
        <name evidence="11" type="ORF">CYQ11_24580</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47989">
        <property type="protein sequence ID" value="PHQ47989"/>
        <property type="gene ID" value="BLA24_31530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15615">
        <property type="protein sequence ID" value="PPT15615"/>
        <property type="gene ID" value="CYQ11_24580"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="340"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="524"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ47989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="709" mass="75502" checksum="4675D35E3E7513A4" modified="2018-01-31" version="1">MSTTAELLKGAAELFPDEVVTQAHVRHLDLPYGAGRFALITLDNGFDHTKPTTFGPQSLANLNTAIDQVEAEAAAGEITGVGITGKPFIFAVGADLKGVELLKKHEDALAIGKGGHDVFKRLSSLAVPTFAYYNGAAMGGGVEVGLHCTYRTVSKAIPAFSLPEVFLGLVPGWGGCALLPNIIGADRAVSVIIENSLNQNRQLKGKQVFELGIADAIFEGADFLEQSLLWTASVLKGDTEVVRAEVDRGEAWDQAVERGRFIADSKVHGAAPAAYRALDIIAAAKNGDLRQGFDAEDQALADLIMGDELRSGIYSFNLVQKRGKRPAGAPDKSLARPVNKVGVVGAGLMASQLALLFARRLEVPVVLTDIDQERVDKGVGYVHGEIDKLLLKGRINQDKANRLKAAVTGSLDKAAAFGDADFVIEAVFEEMGVKQQVFAEVEAVVPEHAILATNTSSLSVSEMASKLKHPERVVGFHFFNPVAILPLLEIVRGERTDDAALATAFGVAKKLKKTAVLVKDAPAFVVNRILTRFMGEIQNVIDEGTPVETAEKAVEPLGLPMSPLVLLELVGPAIGLHVSETLHGAFPDRFTVSPNLAAVVKAGKRGFYVHDSGKPELDPEVLALMEQGDSVLTEEQVRARVLDAVAQEIGLMLDEGVVAEAQDIDLCLITGAGWPFHLGGITPYLDREGVSERVNGKRFLPVGVASVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA30</accession>
    <name>A0A2G1XA30_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxoguanine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32100</name>
        <name evidence="3" type="ORF">CYQ11_25160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48086">
        <property type="protein sequence ID" value="PHQ48086"/>
        <property type="gene ID" value="BLA24_32100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15712">
        <property type="protein sequence ID" value="PPT15712"/>
        <property type="gene ID" value="CYQ11_25160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="62"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="47880" checksum="D38B67D02380757D" modified="2018-01-31" version="1">MAAPPPRIVIENCAVATVDAENTEHASGHVVVAGGRIESVGPGAAPEGLTGVVRRVDGTGHLVTPGLVNTHHHFYQWLTRGLAQDANLFDWLVALYPVWSRIDEPMVYAAARGSLAMMVRGGVTTAADHHYVFPRGCGDLLGAEIRAARELGVRFHATRGSMDLGESAGGLPPDFAVESTEDALIATEAAVDAHHDPSFDSMLRVGVAPCSPFSVTTELLRQAAELARRKGVRLHTHGSETVEEESFCKERFGMGPTDYLESTGWLGDDVWMAHCVHMNAADVAAFARTGTGVAHCPSSNARLAAGTAPVPALLRAGVPVGLGVDGTASNESGELHTELRNALLMHRLAGGEKAMDARTALRLGTHGGATVLGRAAETGSLEAGKLADLVLWKLDGLGHSTIADPVAALVLGPPAPVALSLVGGEAVVEDGRLVTADEDAVAREARLESRRLAAVAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAA0</accession>
    <name>A0A2G1XAA0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">ggt</name>
        <name evidence="7" type="ORF">BLA24_32455</name>
        <name evidence="8" type="ORF">CYQ11_25505</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48142">
        <property type="protein sequence ID" value="PHQ48142"/>
        <property type="gene ID" value="BLA24_32455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15768">
        <property type="protein sequence ID" value="PPT15768"/>
        <property type="gene ID" value="CYQ11_25505"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758376" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="33"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="613" mass="64452" checksum="F9EEBAE8931BE57C" modified="2018-01-31" version="1">MALPRPTTHRRLPVLTAAATLLAALGVAPAAAATPGHAPDRTPEKTPVAVGYGGVVSSVDPDASAAGIEVLRKGGNAVDAAVATAAALGVTEPYSAGIGGGGFFVRYDAKTGKVSTIDGRERAPLSAGPDLFLENGKPIPFPDAVTSGLGVGTPGTPATWDTALRTWGSRSLAELLRPAQRLARDGFTVDATFRQQTAENQERFKDFPATTKLFLPGGRLPVVGTTLKNPDLARTYELLARQGVDAVYQGEVGRDIVRTVRKPPVAPGAHRVVRPGDLTEKDLRAYATKRQEPTRTSYRGLDVYGMAPSSSGGTTVAEALNILENGDLSRLDEKTYLHRYIEASRIAFADRNRWVGDPAFEKVPVKGLLSQRFADSRACLVKDDAVLTSPLAPGDPSRPASSCTTRGAAAPTPYEGENTTHLTVADKWGNVVAYTLTIEQTGGSGITVPGRGFLLNNELTDFSFTPVTPGVHDPNLPGPGKRPRSSMSPTIVLEHGKPVFALGAPGGATIITTVLQSLLNHVDRGMPLVDAIAAPRASQRNAAATELEPGLWNSPLRRQLEAKGHVFKQNAEIGAATGVQRLPDGRWLAAAETARRGGGSAMVVRPAGKPPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC3</accession>
    <name>A0A2G1XAC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_32715</name>
        <name evidence="8" type="ORF">CYQ11_25765</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48187">
        <property type="protein sequence ID" value="PHQ48187"/>
        <property type="gene ID" value="BLA24_32715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15813">
        <property type="protein sequence ID" value="PPT15813"/>
        <property type="gene ID" value="CYQ11_25765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="469" mass="48548" checksum="758122DBF5BBACE4" modified="2018-01-31" version="1">MHDTDGTQSRRFGLPTATALVMGNIIGGGIFLLPASVAPFGTVSLLAFGVLTIGAIALALVFGRLTERFPRTGGPYVYAREAFGDFAGFLSAWSYWTMTWVSNAALAVAGVGYVHVLTGGSGSMASDLTVALLLLWLPALANLAGTRWVGAVQMVSTVLKFIPLLFVAIVGLFFFDPSNLGSFTEGGSSWSGSLTASAAILLYSYVGVESAAMSAGEVRDPERNVGRASVLGTIGAAVVYLLGTLSVFGTVAHDKLVKSSAPFSDAVDAMFGGEWGGTLIAFAAVVSIVGALNGWTLMSAQAPYAAAQDGLFPAAFAKKRRGVPTAGVLAAAVLATVLTVINYTSGVAGVFEILVLITTFSATVPYLLATAAQVYFLLRGRRDKVQPARLTRDLVLALGGFGFSFWLVAGAGYAAVYQGVLFLFAGVIVYVWMAARRPADATASAEAGESAEAAEAVEAAEPAEKERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC6</accession>
    <name>A0A2G1XAC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32710</name>
        <name evidence="4" type="ORF">CYQ11_25760</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48186">
        <property type="protein sequence ID" value="PHQ48186"/>
        <property type="gene ID" value="BLA24_32710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15812">
        <property type="protein sequence ID" value="PPT15812"/>
        <property type="gene ID" value="CYQ11_25760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="27971" checksum="C0E49E0123CAF673" modified="2018-01-31" version="1">MPTSASIILFVFGGLMVLISLLGSGFAVREISFPRISPLIRSTAALLGAGLVATSIVFLVTQEKKEPAPGPPTAGPVPDPARTSPPPVSVSPTAPAPPATAPPRPAPTGPPDDGTPTQALLTHVPSGLRSGCRAVDRSRYGASVTAVVECRLTGGVTAVYAQFTDVSGMNTRLGEIMSRETFTHSGCGASTPLNGRQRFVVGNNRSEGTLICFQGDDGDPHLIWSDESLAIMTEAQSAPVSYGDLLDWWRKSAGPVPATPDEAAQNAGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF5</accession>
    <name>A0A2G1XAF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32770</name>
        <name evidence="6" type="ORF">CYQ11_25820</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48195">
        <property type="protein sequence ID" value="PHQ48195"/>
        <property type="gene ID" value="BLA24_32770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15821">
        <property type="protein sequence ID" value="PPT15821"/>
        <property type="gene ID" value="CYQ11_25820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="30899" checksum="6B4431722CA20E5E" modified="2018-01-31" version="1">MSKVPTITLNNGVEMPQLGYGVWQVPDDQAAEAVSSALEVGYRSIDTAAIYENEEGTGKALTTSGIPRDELFVTTKLWNSASETWTRDNVLREFDASLSKLGLDYVDLYLIHWPRAMRDDYLTIWRTFAEIAESGRARAVGVSNFQPAHLERLLAESPLVPAVNQIELHPYFQQAGLREFDARHGIVTEAWSPLGQGRGLLEDPALVRIGAKHGKSAAQVVLRWHLQVGNVAIPKSVTPSRIRENFDVLGFELDADDLAALAGLDKGTRLGPDPDEFDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAH3</accession>
    <name>A0A2G1XAH3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32885</name>
        <name evidence="4" type="ORF">CYQ11_25935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48215">
        <property type="protein sequence ID" value="PHQ48215"/>
        <property type="gene ID" value="BLA24_32885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15842">
        <property type="protein sequence ID" value="PPT15842"/>
        <property type="gene ID" value="CYQ11_25935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="99" mass="10811" checksum="DC0C32F59E5C862A" modified="2018-01-31" version="1">MFVLELTYIAPIERIDAALAEHVAWLDAHYASGVFIASGRKVPRDGGIILALGDDRAKIEEITQSDPFTVAGVCEYTITEFIPTKTAEGLAQYRQSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAI9</accession>
    <name>A0A2G1XAI9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33115</name>
        <name evidence="3" type="ORF">CYQ11_26165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48254">
        <property type="protein sequence ID" value="PHQ48254"/>
        <property type="gene ID" value="BLA24_33115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15884">
        <property type="protein sequence ID" value="PPT15884"/>
        <property type="gene ID" value="CYQ11_26165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="86" mass="9167" checksum="3274161AC625F3A6" modified="2018-01-31" version="1">MDLEHVYNGMPATDLGTEGWSKPWSGGNGGSCVEVMRLCDGRVALRQSTDPGGPALIYTRHEMETFIRGAKAGEADFLLAGPRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAJ5</accession>
    <name>A0A2G1XAJ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1/PfpI family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32980</name>
        <name evidence="3" type="ORF">CYQ11_26030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48232">
        <property type="protein sequence ID" value="PHQ48232"/>
        <property type="gene ID" value="BLA24_32980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15859">
        <property type="protein sequence ID" value="PPT15859"/>
        <property type="gene ID" value="CYQ11_26030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="22371" checksum="9BB82A3C497EB4AD" modified="2018-01-31" version="1">MQIAVLLFPGFTALDAVGPYETLGRMPGAEPVLLAERPGPVPNDRGHFSLVAEASLADVPHPDVVVVPGGPEANLPRRPGPVLDWLRAVDPGTVWTTSVCTGSLLLGAAGLLRGRRATSHWTALDVLASYGADPTGERVVTDGKYVTAAGVSSGIDMGLTLVGRIAGDEAARSAQLLLEYDPQPPYDAGSPEKAPADLVARFRKIYEERRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAN6</accession>
    <name>A0A2G1XAN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide sugar-1-phosphate transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphocholine cytidylyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33015</name>
        <name evidence="3" type="ORF">CYQ11_26065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48239">
        <property type="protein sequence ID" value="PHQ48239"/>
        <property type="gene ID" value="BLA24_33015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15866">
        <property type="protein sequence ID" value="PPT15866"/>
        <property type="gene ID" value="CYQ11_26065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="27250" checksum="CFC6D754793A0541" modified="2018-01-31" version="1">MIGLVLAAGAGRRLRPYTDTLPKALVPVGPEGDEESITVLDLTLGNFAEVGLTEVAIVVGYRKEAVYARKEALEAKYGLKLTLIDNDKAEEWNNAYSLWCARDVLGRGVILANGDTVHPVSVEKTLLAARGQGQKIILALDTVKSLADEEMKVVVDAEKGVQKITKLMEPAEATGEYIGVTLIEAEAGEELADALKTTFERDPDLYYEDGYQELVNRGFKIDVAPIGDVQWVEIDNHDDLAKGRGIACQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAQ0</accession>
    <name>A0A2G1XAQ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_33445</name>
        <name evidence="4" type="ORF">CYQ11_26495</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48308">
        <property type="protein sequence ID" value="PHQ48308"/>
        <property type="gene ID" value="BLA24_33445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15939">
        <property type="protein sequence ID" value="PPT15939"/>
        <property type="gene ID" value="CYQ11_26495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304864" evidence="2">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="17606" checksum="6FE73E7B10E4A056" modified="2018-01-31" version="1">MRRVVHALAWVLATGVAMAVSWYGVRTVLTDTAYEPPRALPISHTPARPPESAPPTTASVRPPSPPPPPSAPAASARPATPDPSPPASRAPSDGGGVRSYPVKGGRAVFDIGEKSATLVSATPDEGRQMRVWTQTAWIRVDFVAGTQTSSVFVTWNGHPPQVQTVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAS7</accession>
    <name>A0A2G1XAS7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33275</name>
        <name evidence="3" type="ORF">CYQ11_26325</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48279">
        <property type="protein sequence ID" value="PHQ48279"/>
        <property type="gene ID" value="BLA24_33275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15909">
        <property type="protein sequence ID" value="PPT15909"/>
        <property type="gene ID" value="CYQ11_26325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="109" mass="11275" checksum="0185009C8B97BCF6" modified="2018-01-31" version="1">MVSQDLRRIRDVGAAPVRLASAVPGGPRSAGCFGPVRLRTVLFRATGRPVTVRSASVRTVAVQEALSRGDAEVSVPGRRAVTVPEAPQQGGAGRPARLPPVPMASRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAY7</accession>
    <name>A0A2G1XAY7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_33145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48390">
        <property type="protein sequence ID" value="PHQ48390"/>
        <property type="gene ID" value="BLA24_33145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="1093" mass="115850" checksum="563687C0D834A219" modified="2018-01-31" version="1">MAGAAAGLPVDAVAAVSEGGGSGAGATVLSFTGATNGAATLSPAGDRLIAEVQNVLWSVPRAGGEARAITPADLEPTRPVHSPDGRTVAVCAYRGGGFHIWTLRPDGSGLRQVTDGPWDDRGPAWSPDGTRIAFASERGGDPVAGSPYRVWVVDVRTGALTQLSGLAGQQGPDQEGAWEDFDPVWSPDGARVLFVRGKVVGSALDARAVVSVPADGRGPVRVEHTESAAGQVMTPAVSPAGRLAYLRTTAAPAASCTLVVDGAAVPVEGDLEPVPPRWVSREELLLTVSGQFHLVRPEAPAAGPGSTAPAMAVTAATAAATRVAPASASLPHPSAAPPPTPPTTGRTVVSAVIPFTAELPVDRPRYEVKRYDFATEGVRRVRALHLPALSPDARQVAFAALNSLWIADVSGGGAPRRVVTADPTRYLLAPSWSRDGRSLIYADDRGGLLAVRRRDLASGEETVLADGGRVHPALSPDGTRLACLDMSGNLVVRDLAAGKDHVLAAPLGAGGLPGRPSWSPDGRFLALCDRNRLNQRFREGYNLIRVVDAGTGAARLHALAPHVSLSDRYDSGPVWSPDGRSMAVISESALWLLPVRADGTPDGEPRRLTDEAADHPSWSADGRRILYLSAGRLCLLDTTDGSARTVPVALDYRRPAPADTVVHAGRFWDGTGEAVREDVDLVVRGGRIAAVEPHRARRAARQRVDASRRTVIPGLWDAHTHPWQYTYGGRQTALQLAYGITTAVSLGGFAYEQARLREAVAAGALAGPRLLTAGELLDGSRVAYSMGRAHRTEEGLRRSLSRATALDWDFVKTYVRAPGWVMEEAARFAHERLGVRTGSHLCSPGVQLGQDLTTHLLATQRLEFGHATSATGRAYEDLTEIYTATDFHMIATLFTSVPLLGSDPALAEDPRVTELMPPWDVALVRQTAGQAPSADQLTALRREIEVYRKVLSGGGLVALGTDAPLVPVGLSLHMGLRALHQHGLSAAQALRTATLLPARVFGAERDLGTLEVGKLADVTLVDGDPFSDFDSLVRTSAVLRGGFLYEQGELVGAYKRAAAPAMREDRADRTDWLEVGRQLRRDSCCDMEQHLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAZ5</accession>
    <name>A0A2G1XAZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32870</name>
        <name evidence="3" type="ORF">CYQ11_25920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48382">
        <property type="protein sequence ID" value="PHQ48382"/>
        <property type="gene ID" value="BLA24_32870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16807">
        <property type="protein sequence ID" value="PPT16807"/>
        <property type="gene ID" value="CYQ11_25920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="468" mass="49125" checksum="6FBF5A57BEBD1438" modified="2018-01-31" version="1">MAAVALAFAVVQLCFAVAHMDLGWDETVYLSQVDPRNPAAFFSAPRSRGVSFLAAPVVALTSSVLVLRVVLVLLSSAALYAAFAVWRPLLGRVRPALAALLFAGLWITVLSGPEVMPNLWVALTAVAAAGWFLRARADAPGRRGARAALAATLAAATLFRAPDGVWLALPMLAACAAVRAWRRPGTVAAVLGGLALGGVQWAVEAYARFGGIGRRLSVSSDTEGGMGAHLGAGLRAALRSLNGPQLCRPCHVAGPSVTHSLWWLLLPLLAACALALAARRRADAAATWLPVACALALAAPYLLLLDYSAPRFLLPSYALLALPVAGLAADAVRAVRPGRPRLVVAALLGAVLAAHLTVQTEELRLNTADARDTTVRYRRAADELGRLGLTAPCLVTGPRAQPIAYEAGCASAQTMGNNRSTTTAGIVRAAHRMPTALLFDTEDPYLPAYARDWHPHPLPGTDWVAYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB40</accession>
    <name>A0A2G1XB40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">S1 family peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_29145</name>
        <name evidence="11" type="ORF">CYQ11_06330</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48443">
        <property type="protein sequence ID" value="PHQ48443"/>
        <property type="gene ID" value="BLA24_29145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12561">
        <property type="protein sequence ID" value="PPT12561"/>
        <property type="gene ID" value="CYQ11_06330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758313" evidence="7">
        <location>
            <begin position="39"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="119"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="306" mass="30738" checksum="AA800C69935D23C6" modified="2018-01-31" version="1">MRIKRTTPHGGTDRRTKALAVASGLVAVSALVAGTAHAAPPAAAVHSAALAATASAAVESADVPGTAWSLDPTTNTLVVTADSTVPAAGLERIRQRAGAAADAIRVERTPGTFRTLLAGGDAIYAPSWRCSVGFNVRKGSTYYFLTAGHCTEGKPPYYADSGHATSIGPTTGTSFPGNDYGIVQYANGSLAHPSAVDLYDGSTQRITSAGNATVGQSVKRSGSTTKVHGGKVTGLNATVNYGNGQIVRGLIKTDVCAEPGDSGGALFAGSTALGLTSGGSGNCRSGGTTFFQPVTKALSAYGVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB98</accession>
    <name>A0A2G1XB98_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29460</name>
        <name evidence="4" type="ORF">CYQ11_06015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48490">
        <property type="protein sequence ID" value="PHQ48490"/>
        <property type="gene ID" value="BLA24_29460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12511">
        <property type="protein sequence ID" value="PPT12511"/>
        <property type="gene ID" value="CYQ11_06015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="JmjC_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="PTHR13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="Cupin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="99"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="395" mass="43238" checksum="03B942FDAC11D36B" modified="2018-01-31" version="1">MLDAASWAGRLGGDKFLAQTYHRSYAHFPGVADAAGLFSWDDLNRIIATQRLEPPRLRLSVDGEMVPLHRYAIPTTNRRAVTWSRIQPSEFHAQLRDGASLVLDAVEKIHPAVGAAAEGLERFLGTSVQANVYASWTEREGFGRHWDDHDVVVVQLHGSKRWRLWGVTREAPTFRDVESPEEPEGDPLADFVLAPGDVLYLPRGWWHSVTADQGSESLHLTFGMVPHTGADLMLWVVDQLRASLALRRDIPRFGSLAEQSDFIDSVRREVADMMADPRLVERWAESIDTTDMGHVIPSLPYVDGLPAQGEITVKLTAPRGRLTANREQGTVTFSAAGTAWDFAESAAPALGTLLTNQPTTLGEMADSAGLDVKEVAELVSVLIDGHAVAVVGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBE3</accession>
    <name>A0A2G1XBE3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29920</name>
        <name evidence="5" type="ORF">CYQ11_05550</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48567">
        <property type="protein sequence ID" value="PHQ48567"/>
        <property type="gene ID" value="BLA24_29920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12431">
        <property type="protein sequence ID" value="PPT12431"/>
        <property type="gene ID" value="CYQ11_05550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758454" description="GHL10 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="42"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="414" mass="47273" checksum="5032CD4238A6FEF4" modified="2018-01-31" version="1">MGRMSRRGFGVVAASVMTAMLASGEAAALEVRDGAAPTRRREFRGMWTATVVNVDWPSAPGLSPERQRTELLGLFDAAVSRRLNAVILQIRPTADAFWPSRYEPWSEYLTGTQGRSPGWDPLAFAVREAHKRRLELHGWFNPYRVANHTDPGRLVPTHPVRIHPEWAVPYGGKLYYNPGLPEVRRFVQDAMLDAVWRYDLDGVHFDDYFYPYPVAGQTFDDTAAYERYGAGFPDRAAWRRDNIDRLVRETGERIKRRKRHVRFGVSPFAVWRNRATDPLGSDTRAGVQTYDDLAADTRRWVREGWIDYIVPQCYWHIGFGPADYAKLLPWWAETVRGTRVQLYIGEALYRAGDPAQPAPWQDPGELSRHLDLARGRPEVLGNVFFSAKYVASDPVGAMARVVKDHYPHRARPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBG9</accession>
    <name>A0A2G1XBG9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1918 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01350</name>
        <name evidence="3" type="ORF">BLA24_29925</name>
        <name evidence="5" type="ORF">CYQ11_05545</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000020">
        <property type="protein sequence ID" value="PHQ53399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48568">
        <property type="protein sequence ID" value="PHQ48568"/>
        <property type="gene ID" value="BLA24_29925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53399">
        <property type="protein sequence ID" value="PHQ53399"/>
        <property type="gene ID" value="BLA24_01350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12430">
        <property type="protein sequence ID" value="PPT12430"/>
        <property type="gene ID" value="CYQ11_05545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="66" mass="7175" checksum="A9617F94938BFBD3" modified="2018-01-31" version="1">MHASKGDRLVVHGRVVGKPDHVVEVVEVLGPNGTPPYRVRSENGHETIMSPGPDSVVDHRKAADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBL3</accession>
    <name>A0A2G1XBL3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_29315</name>
        <name evidence="11" type="ORF">CYQ11_06160</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48591">
        <property type="protein sequence ID" value="PHQ48591"/>
        <property type="gene ID" value="BLA24_29315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16373">
        <property type="protein sequence ID" value="PPT16373"/>
        <property type="gene ID" value="CYQ11_06160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="26435" checksum="62F4D3F0763E9BD3" modified="2018-01-31" version="1">MLVRNVQRMRRAPGLFLITMTMPVTLLLFFGYVFGSAVALDGGGDYRAYLVPGLFAATAVGGVLTSMLSSAQDHQRGVMDRFRTLPMSRFAIPAGQTAFDVLLAAAGLVPLALCGYAVGWRIEGGAGPAAGAFALLLLFRLVTAWFGHWLGLLLKKEEAAGQLGGATFMLPLLSNAYVPTEGMPGWLRTAADWNPVSAVGAACRDLFGNARPAADAAWPVAHPLAASLGWAAVLLAVFVPLTVRRYGRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBN8</accession>
    <name>A0A2G1XBN8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_28325</name>
        <name evidence="14" type="ORF">CYQ11_07145</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48628">
        <property type="protein sequence ID" value="PHQ48628"/>
        <property type="gene ID" value="BLA24_28325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12693">
        <property type="protein sequence ID" value="PPT12693"/>
        <property type="gene ID" value="CYQ11_07145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758457" description="Cytochrome bc1 complex Rieske iron-sulfur subunit" evidence="11">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ48628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="143" mass="13889" checksum="A3919478A52345B2" modified="2018-01-31" version="1">MSSPTASSASRRTVLRGAALAGVAGLGASACSGGAGAKGPAVPTAPVDLGAAGEVPVGGARLYREQRLIVAQPVEGQYKAFSAVCTHAGCVVDKIEDGKVNCPCHGSKFDAQTGKVLQGPAGAPLPSVPVKADGGKLVAGPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBQ9</accession>
    <name>A0A2G1XBQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase HrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28220</name>
        <name evidence="5" type="ORF">CYQ11_07255</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48609">
        <property type="protein sequence ID" value="PHQ48609"/>
        <property type="gene ID" value="BLA24_28220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12710">
        <property type="protein sequence ID" value="PPT12710"/>
        <property type="gene ID" value="CYQ11_07255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="223"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="889" mass="93462" checksum="1D640ECCDB2D4233" modified="2018-01-31" version="1">MIPADALERLPVRTALPALTRALDEHGAAVLCAPPGTGKTTLVPLVLAGLAGPPGDEARDAAERPVRRVVVAEPRRIAARAAARRMAWLLGEEVGGRVGFTVRGERRAGPSTVVEVVTTGVLLQRLQRDPELAGVDAVVLDECHERHLDADTAAAFLLDVRAALRPELRLVAASATTDAEGWARLLGGAPVVEAQGVSHPVDVVWAPPERPVRPPHGMRVDPVLLEHVAAVVRRALREREGDVLCFLPGVGEIGRVAGLLGGAQGPGGAEVLQVHGRAPATVQDAVLAGGSGRRRVVLATSVAESSLTVPGVRIVVDAGLAREPRTDHARGLSALTTVRASRAAARQRAGRAGREAPGTVYRCWAEADDVRLPAFPAAEITVADLTAFALQVACWGDPDATGLALLDAPPPGALAAARGVLTATGAVDAVGRPTDRGRRMARLGVHPRLARALLDGAREVGARRAAEVVALLSEEPPREYGDDLAAAWRSARRGGDAYGARWKAEAKRLESAVRSASGGAAPEARGPQRTEGPGQPAASGAGGARDGLSAPQGGSRSPAGSPHADDAVAGLIAALAFPERVARARGGESYLMVSGTGAGLGEGSRLHSAPWLAIAVADRPVTAASARVRLGAVIDEDTAREAAGALFSESEEVCWSGERRDVVARRVARLGAVELTAGTLASPDPSLVRAALVEGLRREGLGLLRWSPEAVGLRQRLAFLRRELGDPWPDVSDEALLGRADDWLGWELDRARRRADLERLDAGKGLERLLPWAGGEAARLEELAPERIEVPSGSRIRVDYAGEQPVLAVKLQELFGMRETPRLAGGRVPVLVHLLSPAGRPAAVTADLASFWRDGYRSVRAELRGRYPQHPWPEDPSTATATRRTNARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC34</accession>
    <name>A0A2G1XC34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27415</name>
        <name evidence="6" type="ORF">CYQ11_18230</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48803">
        <property type="protein sequence ID" value="PHQ48803"/>
        <property type="gene ID" value="BLA24_27415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14547">
        <property type="protein sequence ID" value="PPT14547"/>
        <property type="gene ID" value="CYQ11_18230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="22832" checksum="AD2B2407E18BEBB0" modified="2018-01-31" version="1">MIRVAVVDDEQLVRSGLRMILGTAPDIEVVADCGGGAAVATVTGHAPDVVLLDVRMPDVDGLTVLRALRALAHPPAVAMLTTFDTDEYLAAALRDGAAGFLLKDTDPEQLVRAVRTLAAGGSVLDPGVTRAVIGGYLAAEAENTAARAVQALTPREREVLAHLGEGLANPQIAERMGLAPSTVKDHVRAVLGKLGGLNRVQAAVVADRAGLVTARRCGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCA8</accession>
    <name>A0A2G1XCA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27770</name>
        <name evidence="3" type="ORF">CYQ11_17870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48862">
        <property type="protein sequence ID" value="PHQ48862"/>
        <property type="gene ID" value="BLA24_27770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14491">
        <property type="protein sequence ID" value="PPT14491"/>
        <property type="gene ID" value="CYQ11_17870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7125" checksum="0ED3FD4B51FCD032" modified="2018-01-31" version="1">MVNRSPFSSHGSLGSQKLAKGELRTTDVRLRVASGAPPGHATVMMWGGPENGSYQRATTRVIEVTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCD4</accession>
    <name>A0A2G1XCD4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetracycline repressor protein class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_27515</name>
        <name evidence="8" type="ORF">CYQ11_18130</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48819">
        <property type="protein sequence ID" value="PHQ48819"/>
        <property type="gene ID" value="BLA24_27515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14535">
        <property type="protein sequence ID" value="PPT14535"/>
        <property type="gene ID" value="CYQ11_18130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="218" mass="22953" checksum="3A4A05710A29CE13" modified="2018-01-31" version="1">MVAKKRTRGERAGLTRHRILDAALELVDREGRTALTMRRLGTELGVEAMTLYHHVPNKDALLDGLVERVFAEALPLADEDADWRTLLRTYAFSLREALLRHPGVLPLVAGRPAVTPATLDAVERGLGALTSAGFPLGPAVDALNSLSLFVIGHTAAEAAGPPADAPGSAAWLTGLDAERHPLVVEAAATGAGTDDARRFRFAVEALLAGFAATDPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG1</accession>
    <name>A0A2G1XCG1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sensor domain-containing diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27990</name>
        <name evidence="6" type="ORF">CYQ11_17650</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48900">
        <property type="protein sequence ID" value="PHQ48900"/>
        <property type="gene ID" value="BLA24_27990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14451">
        <property type="protein sequence ID" value="PPT14451"/>
        <property type="gene ID" value="CYQ11_17650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="211"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="282"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="439"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="569" mass="61272" checksum="5D6DD482014ABF60" modified="2018-01-31" version="1">METESEPYVRLATLRQVHKVVAELNTARSLADTLQTVADGIVTGLGYELAAVNLVRPDGDLVVAAVAGSASAEALMAGRVGSRVSWERRLSMGDHWGDLRFIPYTEGWVLDDDDVPQWHTAGPAPRFADEWHPMDRLFAPMYTAGPGGGELLGVISVDKPTNGRRPGAWGREALQMYASQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAELGGDQHGRLHRTNDALCRLLGRPASQMRRYSFADLVHPDDIGTLLRTSAEGGRAELRLARRDGTFVWVSLRNSVVADAADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRARLSARLCDRPPGSEPHAVGAAAPYGSLEGFAEVESAGYAHGHGFGADTGPDYAPDFGADDFAGVPAGGYDHHEHTVAPDEEADDGAKGLAVLFCDLDGFKAINDRFGHHTGDAVLIEVARRLSNGVRDGDTVARLGGDEFVVLADGLGVADAEDLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAGCGMSADEVLHSADQRMYVEKRSRAKAGRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCN5</accession>
    <name>A0A2G1XCN5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">tsf</name>
        <name evidence="10" type="ORF">BLA24_23230</name>
        <name evidence="11" type="ORF">CYQ11_22845</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49014">
        <property type="protein sequence ID" value="PHQ49014"/>
        <property type="gene ID" value="BLA24_23230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15341">
        <property type="protein sequence ID" value="PPT15341"/>
        <property type="gene ID" value="CYQ11_22845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="73"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="29762" checksum="A28C3237C70CDC3D" modified="2018-01-31" version="1">MANYTAADVKKLREQTGAGMMDCKKALDEAEGNLEKAVEIVRVKGLKGVAKRESRTTENGAVASLIADDNTSGVIVELKCETDFVAKGEKFIAVADALAAHIAKSAPADVDALMASEIEAGKTVQAFVDEANATLGEKIVVDRFAHFADGQVFAYMHRTAADLPPQVGVLVELDKADAEVAKDVAQHIAAFAPKFLSRDAIPADVVENERRVAEATAREEGKPEAALPKIVEGRVTGFFKEQVLLDQAFAKDNKKSVQKVLDEAGVTLKRFARIRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD61</accession>
    <name>A0A2G1XD61_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_23915</name>
        <name evidence="13" type="ORF">CYQ11_22155</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49125">
        <property type="protein sequence ID" value="PHQ49125"/>
        <property type="gene ID" value="BLA24_23915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15227">
        <property type="protein sequence ID" value="PPT15227"/>
        <property type="gene ID" value="CYQ11_22155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="193"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="460" mass="49106" checksum="9F90E512F9C19E5D" modified="2018-01-31" version="1">MAISVFDLFSIGIGPSSSHTVGPMRAARMFVGRLKNEGLLAHTASVRAELFGSLGATGHGHGTPKAVLLGLEGHSPRTVDVEVADDEVERIRTTKRLRLLGAEIGSAHEIDFDDSTQLILHRRRSLPYHANGMTLFAYDEAGAPLLEKTYYSVGGGFVVDEDAVGADRIVLDDTVLKYPFRTGDELLRMARESGLSISAMMMENEKAWRTETEIREGLLEIWRVMQACVTRGMSREGILPGGLKVRRRAANSARQLRAEGDAQARAMEWITIYAMAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYMNFVPGADEEGIVRFLLAAGAIGMLFKENASISGAEVGCQGEVGSACSMASGGLAEVLGGTPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCIERNGMAAAKAVTAARMALRGDGRHHVSLDKVIKTMKETGADMKVKYKETARGGLAVNVIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDI2</accession>
    <name>A0A2G1XDI2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24845</name>
        <name evidence="2" type="ORF">CYQ11_21225</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49290">
        <property type="protein sequence ID" value="PHQ49290"/>
        <property type="gene ID" value="BLA24_24845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15060">
        <property type="protein sequence ID" value="PPT15060"/>
        <property type="gene ID" value="CYQ11_21225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="19685" checksum="372114FF4F050957" modified="2018-01-31" version="1">MAQSLSSFADLIGSADGSAVHLEMRDAYAVDGEADGFAAWKAGHRLDPSDRRSWWRPWLDLVQEVTGKGVTMRRARIVFEPVSEYIRFEHSGTFTNVAAGEEVRWLPRRNASDIALPGNDFWLFDGRIVQFNVFDGDGRWVHTDQTEDPATVRLCVSAFEAVWERGIPHEKYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDI5</accession>
    <name>A0A2G1XDI5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24855</name>
        <name evidence="4" type="ORF">CYQ11_21215</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49292">
        <property type="protein sequence ID" value="PHQ49292"/>
        <property type="gene ID" value="BLA24_24855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15058">
        <property type="protein sequence ID" value="PPT15058"/>
        <property type="gene ID" value="CYQ11_21215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="30557" checksum="81B65B1B93DB2220" modified="2018-01-31" version="1">MTMELRHLRAFLAIAEEGTITRAAARLHTGQPALSRTLRQLEDHLGVRLVDRSTHHLELTAAGRAFHDKAAAALAAVDTALDPRSLTTLPLRLGHPWAALGPHTIPLLRRWDEEHPDVPLELRRVDDRTAGLTRGTVDVALLRGDVTAPGLVTRLLLEEERVAVVPAGSALADRDALTLADLAAWPIALNTVAGTTTLDLWPATARPAATIQVTNTDEWLTAIAAGRAAGITTSATPGLHKHPAIAYRPLTDAPPVPLLLAWRPGPPAHPSIPELVRLAREVVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDJ5</accession>
    <name>A0A2G1XDJ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49307">
        <property type="protein sequence ID" value="PHQ49307"/>
        <property type="gene ID" value="BLA24_24950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="PTHR13136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="213" mass="22173" checksum="22D3A5C165F96375" modified="2018-01-31" version="1">MTTKIAVTVQDVPTPAGDARVHWYLAPSARLVLALGHGAGGGVEARDLQALAAALPRQDVTVALVEQPWRVAGKRVAPAPTSLDEAWRALWPALTAPGLPVVAGGRSAGARVACRTGAELGAAGVLALSFPLHPPGKPEKSRADELTGAGLPTLVVQGGRDPFGRPEEFPPGARPVEVPYGDHGFAVPKKAETTQDEALAVITRAVEEWLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE61</accession>
    <name>A0A2G1XE61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26015</name>
        <name evidence="2" type="ORF">CYQ11_20050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49495">
        <property type="protein sequence ID" value="PHQ49495"/>
        <property type="gene ID" value="BLA24_26015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14854">
        <property type="protein sequence ID" value="PPT14854"/>
        <property type="gene ID" value="CYQ11_20050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="68" mass="7612" checksum="FB4603B22B8CB424" modified="2018-01-31" version="1">MSEGLPGSPGPTLQRIYDELEPDERESVMIRLFDGSSAERLALVLRRHGHAVSASTIRTYRRSLQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE80</accession>
    <name>A0A2G1XE80_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_26180</name>
        <name evidence="13" type="ORF">CYQ11_19460</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49522">
        <property type="protein sequence ID" value="PHQ49522"/>
        <property type="gene ID" value="BLA24_26180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14758">
        <property type="protein sequence ID" value="PPT14758"/>
        <property type="gene ID" value="CYQ11_19460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="81"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="364"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="757" mass="80502" checksum="A9696EBF997D98D7" modified="2018-01-31" version="1">MGRAEARRAQKRGTGPGTGGKKPKKTGIRRFFTWKMLLAYFVGVIALGAGAFYALYLYVDVPGEGNKAAQLQSNVYKSADGKTIARIGQVNREEVPLDKVPENIRNAVVAAENKNFWTDPGVDLKGTARGIINTVMGRGKQGGSTITQQYIKNYYLDQRQTVSRKVKELIISLKVQDKLSKKKILEGYLNTSYYGRGAYGIQAASRAYYNKDVDKLTLEEGAYLAALLQAPSQYDWSQATEAGKTNAKKRWNYVLDKMVEQKWLGAAERQSMQFKEPGKAKPAAGLAGQNGYLVEAAKREIIRDLVAQGRTQKDAEQEFEAGGWTVTLSIDPTKQKALEKAVHDKLLAELEPGKREVDKHVQAGAVSVDPKTGKVVALYGGQDFIQHQVSNATRADYQPASTFKPLILASALENNSKTQEKKPITPATIYDGTNKRPVVGPGGGGYAPENEDQHSYGPITVQQAMNDSVNSVFAQMVVDVGMDKVKKTAVELGMKSDFEETPAMALGAMGASPMEMAGVYATLDNHGKKVTPSIVASATHRGQEFSLPNAVGATAVDRNTADGLTSVLTGVVNDGTANVVSSAEYQVAGKTGTSDEDLSAWFAGYTPSLVTTVGLFGEDMEKNGKQVTLQNTGGNGRVNGGTYPAKIWAAYNAAVFGDDDKAKFDLETDEPAAPAAPPSPKPSTSPSASTSPKPSNSPSASTSPKPSNSSSSAASPKPSNSTKQPPTPKPSSSSSTGSSTGPVDPGTRPNGGLMPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE87</accession>
    <name>A0A2G1XE87_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25985</name>
        <name evidence="2" type="ORF">CYQ11_20080</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49489">
        <property type="protein sequence ID" value="PHQ49489"/>
        <property type="gene ID" value="BLA24_25985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14860">
        <property type="protein sequence ID" value="PPT14860"/>
        <property type="gene ID" value="CYQ11_20080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="15676" checksum="74EF072C074EB6AD" modified="2018-01-31" version="1">MPLNLKDIPTANGGWFKPKEAAEAMAILVEVKDYERQRPTPNGPKDSALCDVTVFKTPEQLDRLAPEVSKGQRIEQTVLARDLATLVGSAVLVTVTQVPATKPGAHPAWVWKQITDMGIRNKVIAYAEQRDAAVDAAVAAAPSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEB1</accession>
    <name>A0A2G1XEB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26440</name>
        <name evidence="3" type="ORF">CYQ11_19200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49567">
        <property type="protein sequence ID" value="PHQ49567"/>
        <property type="gene ID" value="BLA24_26440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14714">
        <property type="protein sequence ID" value="PPT14714"/>
        <property type="gene ID" value="CYQ11_19200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="1">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="16723" checksum="E62593C0DC4845CD" modified="2018-01-31" version="1">MRERRAERERVRAREFEAFAAGAGGRLLHAALLLTGEPAGRPEAAERLLTAALARTYAAWDRLRGEDPYDLARQELAARYARTARRHRRARGGLLDRLTPQERLVLVLRLHEGVAEEQAAAALGLSEERVRAVCARAVATMRGRRTPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEB7</accession>
    <name>A0A2G1XEB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA carboxylase subunit beta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26535</name>
        <name evidence="4" type="ORF">CYQ11_19100</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49584">
        <property type="protein sequence ID" value="PHQ49584"/>
        <property type="gene ID" value="BLA24_26535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14697">
        <property type="protein sequence ID" value="PPT14697"/>
        <property type="gene ID" value="CYQ11_19100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="276"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="529" mass="57011" checksum="7929EB6F66657960" modified="2018-01-31" version="1">MSEPEHDIHTTAGKLADLQRRIEEATHAGSARAVEKQHAKGKLTARERVDLLMDEGSFVELDEFARHRSTNFGMDANRPYGDGVVTGYGTVDGRPVAVFSQDFTVFGGALGEVFGQKIVKVMDFALKTGCPVVGINDSGGARIQEGVASLGMYGEIFRRNVHASGVVPQISLIVGPCAGGAVYSPAITDFTVMVDQTSHMFITGPDVIKTVTGEDVGFEELGGARTHNTTSGVAHHMAGDEKDAIDYLKALLSYLPSNNLSEPPVFPEEADLEVSDADRDLDALIPDSANQPYDMHTVFEHVLDDGEFLETQALFAPNIVTGFGRVEGHPVGVVANQPMQFAGCLDINASEKAARFVRTCDAFNIPVLTFVDVPGFLPGTDQEYNGIIRRGAKLIYAYAEATVPLITVITRKAFGGAYDVMGSKHLGADLNLAWPTAQIAVMGAQGAVNILHRRSLAAATSPEEQEELRAQLIADYEDTLLSPYEAAERGYVDAVIAPSDTRRHVVRGLRALRDKREALPPKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XED7</accession>
    <name>A0A2G1XED7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26610</name>
        <name evidence="5" type="ORF">CYQ11_19025</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49597">
        <property type="protein sequence ID" value="PHQ49597"/>
        <property type="gene ID" value="BLA24_26610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14683">
        <property type="protein sequence ID" value="PPT14683"/>
        <property type="gene ID" value="CYQ11_19025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011408">
        <property type="entry name" value="Aldehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699:SF211">
        <property type="entry name" value="PTHR11699:SF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="31"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="476" mass="50646" checksum="A2BC258241246514" modified="2018-01-31" version="1">MAFEYAPAPESRSVVDIAPSYGLFIDGEFREATGGKVFKTVSPSTEEVLSEVAQASAEDVDAAVKAARKAFEKWSALPGSERAKYLFRIARIIQERSRELAVLETLDNGKPIKETRDADLPLVAAHFFYYAGWADKLDHAGFGANPRPLGVAGQVIPWNFPLLMLAWKIAPALAAGNTVVLKPAETTPLSALFFADICRQAGLPKGVVNILTGDGSTGAAIVAHDGVDKVAFTGSTAVGKEIARTVAGTDKRLTLELGGKGANIVFDDAPIDQAVEGIVGGIFFNQGQVCCAGSRLLVQESIQDELLDALKRRMSTLRVGDPLDKNTDVGAINSAEQLARITALADSGEAEGAERWAPACELPGNGYWFAPTLFTGVTQAHRIAREEIFGPVLSVLTFRTPGEAVAKANNSQYGLSAGIWTEKGSRMLAVAGKLRAGVVWANTFNKFDPTSPFGGYKESGFGREGGRHGLEAYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE0</accession>
    <name>A0A2G1XEE0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoC</name>
        <name evidence="4" type="ORF">BLA24_26605</name>
        <name evidence="5" type="ORF">CYQ11_19030</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49596">
        <property type="protein sequence ID" value="PHQ49596"/>
        <property type="gene ID" value="BLA24_26605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14684">
        <property type="protein sequence ID" value="PPT14684"/>
        <property type="gene ID" value="CYQ11_19030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="33117" checksum="23465A647332E597" modified="2018-01-31" version="1">MADVTASDGALRRFLHGLPGVDPVGLEARAAALGTRSIKTTAKAYAIDLAISMIDLTTLEGADTPGKVRSLCAKAVNPDPTDRDTPRTAAICVYPDMVATAAEALRGSGVKVASVATAFPAGRAALPVKLADTVDAVAAGADEIDMVIDRGAFLSGRYLSVFEEIKAVKDACRRPDGSAARLKVIFETGELSTYDNIRRASWLGMLAGADFIKTSTGKVAVNATPANTLLMLEAVRDFRATTGVQVGVKPAGGIRTTKDAMKFLVLVNETVGEEWLTNDWFRFGASSLLNDLLMQRQKLSTGRYSGPDYVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE9</accession>
    <name>A0A2G1XEE9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cpaB</name>
        <name evidence="3" type="ORF">BLA24_26340</name>
        <name evidence="4" type="ORF">CYQ11_19300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49549">
        <property type="protein sequence ID" value="PHQ49549"/>
        <property type="gene ID" value="BLA24_26340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14730">
        <property type="protein sequence ID" value="PPT14730"/>
        <property type="gene ID" value="CYQ11_19300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304909" evidence="1">
        <location>
            <begin position="36"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="242" mass="25233" checksum="8E9E44E21AB3557A" modified="2018-01-31" version="1">MNSRQRRGVVLLLLSALCAVGACAGVFAVIEDAESKTGPGTTAYRLRTDVPAYQDLKADAFEKVSVPKRWLPATAVTDLSALRGKIAVTPLRRGSLLQSDMIVARPALEPGKQEIAIMIDAATGVAGKINPGARVNIYATYDAKEQGAKPVSKVIVTGAQVVNVGKLTPFDRDGGRARGASAGSRQAAGEAVPITFALDTKDAQRVAYAESFATHVRLALVAPGGDPGVSSGDRTYTLDGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI2</accession>
    <name>A0A2G1XEI2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26940</name>
        <name evidence="4" type="ORF">CYQ11_18695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49654">
        <property type="protein sequence ID" value="PHQ49654"/>
        <property type="gene ID" value="BLA24_26940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14624">
        <property type="protein sequence ID" value="PPT14624"/>
        <property type="gene ID" value="CYQ11_18695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="201"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="693" mass="74702" checksum="592E99A6663CC80F" modified="2018-01-31" version="1">MKIEFLLHNAYGIGGTIRSTVNLAAALAERHEVRIISVNRPVDEPELTIDPRVTLTPLVDMREGTDGDEYAAPLNQRPSEIFRDERIDNGRMAATALTDERVAAHLAATDADVVIATRPKLIGYLAKYGADRPYLRLGQEHLTHEAHVAELHAVMDPAIAALDAFATVSEADAGHYREALPDAKARILSIPNAVPAPAAEPSDGASKTIVSAGRLVGVKRYDRLIAAFAKVAAERPDWNLRIYGRGPAKAKLRKQIEELGLYERVTLMGARSPIETEWAKGAVAAVASDAESFGMTIVEAMHAGLPVVATDCPYGPREILADGTDGVLVPLDDSDAIDAYADALLRLTGDAALRERLGAAARQAAHRYEPDAIARRYEELFEELRPGCTTARAKKGGLLRGLFGGGRKQQSAPRPQGDVAHPDARCAAAPDGSLVFRLPAGQLTDADSHLLLRHRGSKGKETVRVPLPRQGREAGGWVEARVERAEHTLSEGRWDTYVERAGGKSGEKTRRRLLAGLVEQKALLTLPLRESAEGHSAWVPYATSDGFLAVRTWLRTTHVEADEVRVGDDGITVAVTAHGTALREGAELLARLRGGDGSVGDVRTPLVAGSGCLPYEPMSRRVTADEQDLWDLWVRPAAGAAPVRVGRIAGDFADRKGVDTFPAVTRGEVRLRPFFTVTNDLTVTVKDTAVDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF37</accession>
    <name>A0A2G1XF37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_19600</name>
        <name evidence="6" type="ORF">CYQ11_11195</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49848">
        <property type="protein sequence ID" value="PHQ49848"/>
        <property type="gene ID" value="BLA24_19600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13376">
        <property type="protein sequence ID" value="PPT13376"/>
        <property type="gene ID" value="CYQ11_11195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="154" mass="16707" checksum="622E3A497C283F92" modified="2018-01-31" version="1">MIDRLDGRLIELLAEEPRIGVLEASRRLGVARGTVQARLDRLQAQGVIRSFGPQVDPAALGYPVTAFATLEIKQGQGADVRTHLASVPEVLELHTTTGHGDMLCRLVARSNADLQRVIDRVVGFEGIVRASTAIVMENPVPLRIIPLVKQASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFC0</accession>
    <name>A0A2G1XFC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20105</name>
        <name evidence="5" type="ORF">CYQ11_10685</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49932">
        <property type="protein sequence ID" value="PHQ49932"/>
        <property type="gene ID" value="BLA24_20105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13292">
        <property type="protein sequence ID" value="PPT13292"/>
        <property type="gene ID" value="CYQ11_10685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="32711" checksum="16A7588581A4B0CD" modified="2018-01-31" version="1">MSTGLPMTVPDPSLPARVRIHEVGPRDGLQNEKTVVPTEVKAEFVHRLAAAGLDTVEATSFVHPKWVPQLADAEQLMPMLGDVPARLPVLVPNQRGLDRALALGAREIAVFGSATEAFAKANLNRTVDESLAMFAPVVAAAREAGARVRGYLSMCFGDPWEGAVPIEQTVRVSRRLFDLGCDELSLGDTIGVATPGHVTALLTALNEAGVPTGRLAVHFHDTYGQALANALAALRHGVTTVDASAGGLGGCPYAKSATGNLATEDLVWMLNGLGVSTGVDLGLLTATSVWMAGHLGRPSPSRTLRALSHQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFC8</accession>
    <name>A0A2G1XFC8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20180</name>
        <name evidence="4" type="ORF">CYQ11_10610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="strcj-a0a2g1xfc8">
        <property type="family name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49944">
        <property type="protein sequence ID" value="PHQ49944"/>
        <property type="gene ID" value="BLA24_20180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13279">
        <property type="protein sequence ID" value="PPT13279"/>
        <property type="gene ID" value="CYQ11_10610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758340" evidence="2">
        <location>
            <begin position="28"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="477" mass="53748" checksum="A4B845024CAABAEA" modified="2018-01-31" version="1">MRKALRMLLALTMSIGAVGAGGATAGAATNATEPDIKARILKIPGMSLVSEEKPDDEHRYLVLTYKQPVDHRHPEKGTFEQRFTLLHKSVDRPTVFYTSGYNVNTKPSRSEPTRIVDGNQLSLEYRFFTPSRPQPADWSKLDIWQAASDQHRLYQALKPVYGKNWLATGGSKGGMTATYYRRYYPNDMNGTVAYVAPNDVVNNEDSAYDRFFAGVGDQACRTQLNSVQREALVRRDEIVARYQKWAGENGKTFKVVGSADKAYENVVLDLVWAFWQYHLQSDCASVPATKASTDDLYKFVDNISGFDAYTDQGLEQFTPYYYQAGTELGSPSPKFAHLKGLLRYPDSYQPRTYVPRDIPMTFRSGSMADVDRWVRDNSKNMLFVYGQNDPWSAEPFHLGKNASARHTYRFYAPGGNHGSNISQLVADERAVATAEVLRWAGVAPKAVQQDERQAKPLAPFDKKIDRQTVERQATLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD8</accession>
    <name>A0A2G1XFD8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20265</name>
        <name evidence="2" type="ORF">CYQ11_10520</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49954">
        <property type="protein sequence ID" value="PHQ49954"/>
        <property type="gene ID" value="BLA24_20265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13268">
        <property type="protein sequence ID" value="PPT13268"/>
        <property type="gene ID" value="CYQ11_10520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="31065" checksum="FF520C38FDA60D66" modified="2018-01-31" version="1">MTIRIPDLVNVRTHHPEAVAEAAARRRRRPLIGDSGRLMIVAADHTARGALGVGDRRLAMANRADLLERLCLALSRPGVDGVLATADILDDLLLLGALENKVVMGSMNRGGLFGASFEMDDRFTGPRARDLARRGFDAGKLLLRIDYDDPGSLTTMESAARAVDDMAAHRLPVFVEPFMSRRVGGRVLNDLGAEAVTTSLTIASGLGSASAYTWLKVPVTDDAGDMERVMGATTLPAVLLGGDVGDDQDAAYERWRLALRLPTVRGLVVGRALLYPADGDVAAAVDTAVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ5</accession>
    <name>A0A2G1XFQ5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">BLA24_20940</name>
        <name evidence="7" type="ORF">CYQ11_09840</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50068">
        <property type="protein sequence ID" value="PHQ50068"/>
        <property type="gene ID" value="BLA24_20940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13151">
        <property type="protein sequence ID" value="PPT13151"/>
        <property type="gene ID" value="CYQ11_09840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="106" mass="11522" checksum="4BDD9348104A54AC" modified="2018-01-31" version="1">MYAVVRSGGRQHKVAVGDIVEVDKISDGKVGDSVELSTLLVVDGESVTSDPWVLAGIKVQAEIVDHHKGAKIDILKYKNKTGYRKRIGHRQQYTAVKIVAIPTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFX9</accession>
    <name>A0A2G1XFX9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_21150</name>
        <name evidence="9" type="ORF">CYQ11_09635</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the colicin/pyosin nuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50101">
        <property type="protein sequence ID" value="PHQ50101"/>
        <property type="gene ID" value="BLA24_21150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13119">
        <property type="protein sequence ID" value="PPT13119"/>
        <property type="gene ID" value="CYQ11_09635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037146">
        <property type="entry name" value="Colicin/pyocin_DNase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="5" id="KW-0078">Bacteriocin</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="7">
        <location>
            <begin position="1398"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="716"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1463" mass="158252" checksum="5BCD3F5301F8B15D" modified="2018-01-31" version="1">MSLKHKVQSFLVHHMGLYWPDGDAAKLRKAAKAWRAFAESVDDVRGPVNNTAGALIHNNKGEAIEAFETFWGRYAKGKDAGWLSDVSDSAKEMAKACDKMAAAIDHAMEELWEKIAVDLAVLAAGVTLAIATGGALSGAAAAAAEAIIAGGASVGIAVTATVAEIAGFTLAGAAFGGLEAVTVDLAVAQPMKISLGLQKDFDWGEADKSIKDGMFFGGAFGGAGAFAKNAAEAGGVRNLLNGVRPGLAEEFGAAARLPSQIKCELDPIDVATGAMLLPQTDVTLPGALPLVVERTHLSSYRAGNWFGPTWASTLDERVQLDPEGVVFAAADGMRLVYPVPVPGEPVLPVKGPRWPLEWDGTPDGVMTVTDPYSGLVRTFAHPAPCAVPGAAQLPLESVQDRNGMRVDIERTLSGTPTAIRHSGGYYVAVDTDGPRVTALRLLDEAPSQYEPQQTPGGGTLLVRYGYDDAGNLTEVVNSSGKPLRFTYDAEGRVTSWTDRNGTSYGYVYDERGRVVRTEGSDGFLSGTLEYEDGSRTTTVTDALGRRSVFQYDADALVVSETDPLGHVTLTEWDARGENPLSVTDAGGRTTHYAYDDSGNLTKVTLPDGTAGTAVFDDRCRPVEVTQPGGAVWRHTYDERGNLLTSEDPTGAETRYGYDERGGLTSVTDALGHTQRIECDAAGLPVTLTDPLGRSTTVRRDTFGRVVEVVDPLGHTTRMGWTTEGKPSWRESPDGRRETWTWDGEGNLLTHTDPGGGETRHAYTHFDLPASRTESDGTTYAFAYDKNLRLVEVTNPQGLSWSYDYDEAGRLASETDFNGRTLTYAHNPAGDLVSRTNGAGETLHFTRDELGRVVEQRVADSGETTTYAYDEAGYLNRTANADAEVVFAYDALGRPLSEAVNGRVLTRAYDTLGQCVERTTPSGLRSQWTYDAAGRPVELRGDAGTLAFSYDAAGRETERRLGEGATLGQTWDEADRLTAQSITAKRGPETDRLRQHRAYTYRADGYLTEIRELTSGTRRFDVDRTGRVTGVRAHGWTETYAYDAAGNLTHATAPAHDAPGKREFEGTLLRRAGRTTYEHDAQGRVVRKTRKLLNGQTRTWTFTWDAEDRLTGTTTPDGHCWRYAYDPLGRRISKRRLTDDGAVAESVSFAWDGTRLVEQTTAEGAITTWDHAPGTHRPIAQTDHRTTPAGPAETSLIKQFADADRTPRFHAVVTDLVGTPTELVTPDGELAWQQRTSLWGTRLPAPDAGVDCPLRFPGQYADAETGLAYNYFRYYDPETASYIALDPLGLAAAPNPSRYVSNPYGLADPLGLAPCTPLELEAPKTSTTMRNTPGSVTGGSGLRDVDGKWLRGSAGNAGKIPGQIARALQGRQFRNFDEFRQAFWTEVSKDPNLASQFTKSDRTLMADGKAPWTVKNQALGKNGRYVLHHVVPIQRGGGVYDLDNLIVATPRYHKEVLEPGYHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFY8</accession>
    <name>A0A2G1XFY8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-(Hydroxymethyl)mycothiol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_21245</name>
        <name evidence="8" type="ORF">CYQ11_09540</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50115">
        <property type="protein sequence ID" value="PHQ50115"/>
        <property type="gene ID" value="BLA24_21245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13104">
        <property type="protein sequence ID" value="PPT13104"/>
        <property type="gene ID" value="CYQ11_09540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="25"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="361" mass="37530" checksum="094F54A522500DD4" modified="2018-01-31" version="1">MAQEVRGVIAPGKNQPVRVETIVIPDPGPGEAVVKVQACGVCHTDLHYKQGGINDDFPFLLGHEAAGVVEAVGEGVSEVAPGDFVVLNWRAVCGQCRACKRGRPQYCFDTHNARQKMTLKDGTELSPALGIGAFAEKTLVAAGQCTKVDPGVSPAVAGLLGCGVMAGIGAAINTGGVGRGDSVAVIGCGGVGDAAIAGSRLAGAARIVAVDIDDRKLETALRMGATHTVNSRTTDPVEAIRELTGGFGADVVIEAVGRPETYKQAFYARDLAGTVVLVGVPTPEMTLELPLLDVFGRGGALKSSWYGDCLPSRDFPMLIDLHQQGRLDLGAFVTETIGLGDVEKAFERMHAGDVLRSVVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG47</accession>
    <name>A0A2G1XG47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21640</name>
        <name evidence="3" type="ORF">CYQ11_09145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50181">
        <property type="protein sequence ID" value="PHQ50181"/>
        <property type="gene ID" value="BLA24_21640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13036">
        <property type="protein sequence ID" value="PPT13036"/>
        <property type="gene ID" value="CYQ11_09145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="17523" checksum="339529099D6ECF8E" modified="2018-01-31" version="1">MTVLETAPVRSCATLDRRREARPGGRDRYTISEVAAYAGLSAHTLRWYERIGLMPHVDRSHTGQRRYTDRDLDWLDLVGRLRLTGMTVADMVRYAELVREGEHTLAERERLLTAHREQVRKRIEELRGTLDVLDYKIEIYADAQRRASEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGD2</accession>
    <name>A0A2G1XGD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22160</name>
        <name evidence="3" type="ORF">CYQ11_08625</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50261">
        <property type="protein sequence ID" value="PHQ50261"/>
        <property type="gene ID" value="BLA24_22160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12953">
        <property type="protein sequence ID" value="PPT12953"/>
        <property type="gene ID" value="CYQ11_08625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304842" evidence="1">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="136" mass="14507" checksum="0F57E75670DC13F1" modified="2018-01-31" version="1">MACGLASALAVAAFVLVGRAAAPPHPRPEPRVSARVAAVVPLGTGDPAVTRVRVKVTFTGLKGRAGSLRWHLYNDVTELPMSEESTLGSPVLAWRTTDWKPTLTVPTPPVPWQLRVTAYGPDGRKLASGHSDFAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT7</accession>
    <name>A0A2G1XGT7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF2156 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_16565</name>
        <name evidence="12" type="ORF">CYQ11_16720</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50458">
        <property type="protein sequence ID" value="PHQ50458"/>
        <property type="gene ID" value="BLA24_16565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14287">
        <property type="protein sequence ID" value="PPT14287"/>
        <property type="gene ID" value="CYQ11_16720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="10">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="9">
        <location>
            <begin position="256"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="619" mass="67831" checksum="86B31529E57F202F" modified="2018-01-31" version="1">MSVRVDGKKSDEVPSGPKWLSGLARIVKGPKPESVPAVVGTVGALIGLADIAAGVIPRFRWSRVHALSEVLPGSVTQLAAAGSIIVGILLLMLAHGLKRAKQQAWLAAVILLPIGAAAQLIYRHSYIGGALSLLLFGYLLRHKKSFAALPDPRSRWKALANFIVMGGASFGLGWVIVGSHANQMVGDPPVLEQIEHVIWGLFGFEGSIRYTDHVDYTVGYSLGALGLLTVATTAFLAFRPAYPAPVLTEQDEDRLRELLAKHGARDSLGHFALRRDKSVVFSPSGKAAVSYRVVSGVMLASGDPIGDVEAWPGAIEQFMELAKRHSWTPAVAGCSETGGEVWTRETGLDALEMGDEAIVDVADFSLSGRSMRNVRQMVKRIERNGYSTKVRRVGDLSPEELEAVQKAANAWRDTEDERGFSMALGRIGDPKDLDAIIATAHKDPEEGEDCPFGDLKAMQHYVPWGPDGSSLELMRRDRSADPGMNELLIVAFLQAAPELKVKRMSLNFAFFRSALERGGKLGAGPVVRVQRAVLVFLSRWFQIESLYKFNEKFRPRWEPRFVVFPNNRDLPRIGFAMMQAEGFLELPRLLRRRPVDPQRLAQDEDENGASAQNEVTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH16</accession>
    <name>A0A2G1XH16_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Arsenate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22440</name>
        <name evidence="4" type="ORF">CYQ11_08350</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50429">
        <property type="protein sequence ID" value="PHQ50429"/>
        <property type="gene ID" value="BLA24_22440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12903">
        <property type="protein sequence ID" value="PPT12903"/>
        <property type="gene ID" value="CYQ11_08350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="13353" checksum="F232E4A4A39D0FA1" modified="2018-01-31" version="1">MEIWINPACSKCRGALTLLDAEGAGYTVRRYLDDVPSADEIRAVLGRLGLEPWDITRTQEAEAKELGLGDWPRDAASRDRWVEALAGHPKLIQRPIITADDGSALVARSDEAVREALARSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH86</accession>
    <name>A0A2G1XH86_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17445</name>
        <name evidence="4" type="ORF">CYQ11_15830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50590">
        <property type="protein sequence ID" value="PHQ50590"/>
        <property type="gene ID" value="BLA24_17445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14155">
        <property type="protein sequence ID" value="PPT14155"/>
        <property type="gene ID" value="CYQ11_15830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="2">
        <location>
            <begin position="65"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="23762" checksum="92FDA8A33BA7DF18" modified="2018-01-31" version="1">MCGARAGSLTDESGRPSPLAHRREAHCPGAAVTVREHRQRTVQPASHAAPAEPGQACRWITESERRGVRASSRLLEVAQVEPPADVAAAMKLSKGDVCLMRSQILLFDEEPVELVKSYHPLDLARGTAMMERRKVRGGTPRLLADMGHPPRRCVDHVSARVPTQEQYAALRMPSDLPVLRTLRVVYGDGERPIEVTVTAKAGHLYELRYDFSEGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHD6</accession>
    <name>A0A2G1XHD6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17765</name>
        <name evidence="8" type="ORF">CYQ11_15510</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50643">
        <property type="protein sequence ID" value="PHQ50643"/>
        <property type="gene ID" value="BLA24_17765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14102">
        <property type="protein sequence ID" value="PPT14102"/>
        <property type="gene ID" value="CYQ11_15510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="404" mass="40584" checksum="AA38AC6CB87342D7" modified="2018-01-31" version="1">MPLALLALAIGAFGIGTTEFVTSGLLPEVAEEFGVSIPTAGYLTTGYALGVVAGAPVLAVLGSRVPRKKMLMALMGLFVAGNALSAAAPVFGVMLAGRIVASFAHGAFFGIGAIVAASLVAPQKKAGAIAMMFTGLTVANVVGVPMGTLVGQSAGWRVTFFIIAGLGVLAVLGIAALVPPQPNPERTRISGELAAFRNPQVLLAMAMTVLGFGGVFTMSTYFTPMMTEAVGFAPASVTWLLVLFGLGLVGGNLIGGKYADRALMPMLYTALGGLAVTLALLPLAAHNKITAAVLIPVIGAFGFATVPPLQKRVLDQTADAPTLASAVNIGAFNLGNAIAAWLGGLVISAGFDYTAPNWVGAAMAASALSLAFLSAALERRTDRSGRIVAAGAPTTAGAESIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHV3</accession>
    <name>A0A2G1XHV3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18525</name>
        <name evidence="3" type="ORF">CYQ11_14755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50771">
        <property type="protein sequence ID" value="PHQ50771"/>
        <property type="gene ID" value="BLA24_18525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13971">
        <property type="protein sequence ID" value="PPT13971"/>
        <property type="gene ID" value="CYQ11_14755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304725" evidence="1">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="139" mass="14089" checksum="EB0629F3E542BC7E" modified="2018-01-31" version="1">MFKKVLATAAVTASAVGAIAAPAMAIDNEQDVLNANGAKTGYGNTHTDGKESPQMSLIQGSLNKPCIAIGKLGIQSLIGALNIGLQDVPILTSQQQQQCTDNSTINDGDDPLSHILDEIPILSGNGSGNAGPLFGGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIB3</accession>
    <name>A0A2G1XIB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17025</name>
        <name evidence="3" type="ORF">CYQ11_16255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50869">
        <property type="protein sequence ID" value="PHQ50869"/>
        <property type="gene ID" value="BLA24_17025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16603">
        <property type="protein sequence ID" value="PPT16603"/>
        <property type="gene ID" value="CYQ11_16255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="318" mass="33928" checksum="322FBC913EC2BC02" modified="2018-01-31" version="1">MLVVDGVFDSGLASVLDVLQTANELRGELSQPPAPWQVTCVSPYGPVRTAAGHRVNAVAPEAAPGPDLLVVPGVGHRQPGPLTDWVSAPAQKAVREIVAETRAAGVPLAAACTGTFVLAESGVLDGLQATTSWWLAPDFRQRYPQVALDETHMLTHAPGVTTAGAAMAHLDLALALVRESSPPLADLAARYLVIDSRPTQASYAIPGHLARADPTVGAYERWVREHLDQPLRIADAARALGTSERTLQRALDRVMGVSPLRFAQSIRLEQAAHLLRTTDLPTEAVARRVGYENATTLTSLLRERRGTTPGRLRRNAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIB8</accession>
    <name>A0A2G1XIB8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoK</name>
        <name evidence="6" type="ORF">BLA24_14360</name>
        <name evidence="7" type="ORF">CYQ11_13715</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50973">
        <property type="protein sequence ID" value="PHQ50973"/>
        <property type="gene ID" value="BLA24_14360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13805">
        <property type="protein sequence ID" value="PPT13805"/>
        <property type="gene ID" value="CYQ11_13715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="99" mass="10731" checksum="EE9153C2EE38A77A" modified="2018-01-31" version="1">MNPVNYLYLAALLFTIGAAGVLIRRNAIVIFMSVELMLNACNLAFVTFSRMHGNLDGQIIAFFTMVVAAAEVVIGLAIIVTIFRSRHSASVDDASLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIC0</accession>
    <name>A0A2G1XIC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_14500</name>
        <name evidence="10" type="ORF">CYQ11_13575</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50998">
        <property type="protein sequence ID" value="PHQ50998"/>
        <property type="gene ID" value="BLA24_14500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13780">
        <property type="protein sequence ID" value="PPT13780"/>
        <property type="gene ID" value="CYQ11_13575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="663" mass="68096" checksum="06916CC024B5EF04" modified="2018-01-31" version="1">MSTTTTAVLVPLLPFLGAVAGLMAGRRGPGFVRPLAVLPTALSAVLAVAVAWRQGGGEALDAATRLTPTGSVPIDLALHLDGFAVLVAVLVGVVATCVQLYSTAYLRDDPRYPSYAALVSLFTSAMLLVVYSGDLMVLLVGWEIMGICSYFLVGHYWETEAARAASLKAFLVTKLGDVPFLIGVFALAADAGTFRINGILSAAVAGDIQHPTLVALLLLAGVAGKSAQFPLHTWLPDAMAGPTPVSALIHAATMVAAGVYLVARLLPVFTASAAALVVLAVMAAVTMVGSALAALAQDDVKRVLAYSTVGQLGYMTGALAVGDRGAAVFHLISHGAFKALLFLGAGVIIHAAGTNSLAAMARMKGLARRVPDAYWTMTVALLALAAIPPFSGFFSKEAVLGAAEHAATGHSPGIPGAVGWTVLVAGLLTALLTAAYATRLWLLAFHGKGTEAPDHGREPLAMNGVLWVLFLPTVALGLAAWKLPRWFDGRSLTPALTTSVLSTGCALAGLLVMYAAWRQTSAAAARTPLGAVAADPEAAPYVSEEETIATHEAAYGGIAGAPDPADPGRVLLGPLHRHAVTGFHLDAVYSALFVRPTRGAARLVRFLDREVVDAYVRGAGTAPRLLGAAVRRAQTGNVQTYLGALLAGSVVLAVAAVLVATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG0</accession>
    <name>A0A2G1XIG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_14605</name>
        <name evidence="8" type="ORF">CYQ11_13470</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51013">
        <property type="protein sequence ID" value="PHQ51013"/>
        <property type="gene ID" value="BLA24_14605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13765">
        <property type="protein sequence ID" value="PPT13765"/>
        <property type="gene ID" value="CYQ11_13470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="471" mass="48095" checksum="E4E3F40235D10FAC" modified="2018-01-31" version="1">MQSPRTAGWALLITGIAGFMAALDNLVVTTALPAIREDLGGALGDLEWTVNAYTLTFAVLLMFGAALGDRFGRRRLFMIGVTIFTGASAAAALAPGIEALIAARAVQGAGAAIMMPLTLTLLTDAVPAERRGMAYGIKGAVDGLAVATGPLIGGTLTEHVSWQWIFWLNVPLGLALLPLARLRLRESHGTGARLDATGTLLVSGGLFGVVYGLISSHSDGWTSAKVLASLTAGAALLCGFVVHGARAKNPMLPMRLFRSRAFSAVNSASLLMFFGMFGSIFLLSQFLQNVVGYSPTEAGLRMLPWTAMPMVAAPLSGLLADRIGSRPVVAVGLGLQALGLALFAFVVDPDVSYAAQLPAMIVSGVGMGLFFAPAAKLVMSSVRPAEQGIASGANSALREVGGALGIAVLGSVFAAQGGYGSPTLFVDGLTPALWGGAAMVAVAALAALLIPARAGGTARPEPETARVPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XII0</accession>
    <name>A0A2G1XII0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ORF">BLA24_14745</name>
        <name evidence="14" type="ORF">CYQ11_13325</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51036">
        <property type="protein sequence ID" value="PHQ51036"/>
        <property type="gene ID" value="BLA24_14745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13741">
        <property type="protein sequence ID" value="PPT13741"/>
        <property type="gene ID" value="CYQ11_13325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="276" mass="30280" checksum="057A76A629B8C9BB" modified="2018-01-31" version="1">MGQKVNPHGFRLGITTDFKSRWYADKLYKDYVKEDVAIRRMMTKGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGELEKLTGKQVQLNILEVKNPEVDAQLVAQAVAEQLSSRVSFRRAMRKSMQSTMKAGAKGIKIQCGGRLGGAEMSRSEFYREGRVPLHTLRANVDYGFFEAKTTFGRIGVKVWIYKGDVKNIAEVRAENAAARAGNRPSRGGAQDRPARGGRGGERGGRGRKPQQNAAAEAPKAEAAAAAPAESTGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIL4</accession>
    <name>A0A2G1XIL4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fahA</name>
        <name evidence="10" type="ORF">BLA24_14390</name>
        <name evidence="11" type="ORF">CYQ11_13685</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50979">
        <property type="protein sequence ID" value="PHQ50979"/>
        <property type="gene ID" value="BLA24_14390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13799">
        <property type="protein sequence ID" value="PPT13799"/>
        <property type="gene ID" value="CYQ11_13685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="113"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="393" mass="42073" checksum="A23ED700D463A525" modified="2018-01-31" version="1">MPQHGPRDLPEGDPFGPATLPYGVFTTADEPGRPRVGVRYGAHVLDAAAAAAAHGSAYAGLLDRPTLNPLMAAGRPVWRAVRAEVRGWLADEAHFHPLDEVTLHLPFEVADYVDFYASEHHAGNVGRIFRPDAPDPLTPNWKHLPIGYHGRAGTVVVSGTDVVRPRGQRKAPSDEAPSFGPSLRLDLESEVGFVVGTPTELGTPVTLEDFREHVFGVCLLNDWSARDVQAWEYVPLGPFLGKSFATSVSAWITPLEAFDAARTAPPERTHPLLPYLDDSGAEPGGIDLRIEVAVNGETITRPPFSAMYWTAAQQLAHMTVNGASLRTGDLYASGTVSGPEPDQVGCLLELTQGKGPWLADGDVVTLTAWAPGPDGTRVGLGEVTGRIVPAHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM9</accession>
    <name>A0A2G1XIM9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">BLA24_14775</name>
        <name evidence="10" type="ORF">CYQ11_13295</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51041">
        <property type="protein sequence ID" value="PHQ51041"/>
        <property type="gene ID" value="BLA24_14775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13736">
        <property type="protein sequence ID" value="PPT13736"/>
        <property type="gene ID" value="CYQ11_13295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="90"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="21049" checksum="9CDB85299558AA35" modified="2018-01-31" version="1">MTATTNAPRLKLRYREEIVGKLREEFSYENIMQVPGLTKIVVNMGVGDAARDSKLIEGAIRDLTTITGQKPAVTKARKSIAQFKLREGQPIGAHVTLRGDRMWEFLDRTLSLALPRIRDFRGLSPKQFDGRGNYTFGLTEQVMFHEIDQDKIDRVRGMDITVVTTATNDDEGRALLRHLGFPFKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIR9</accession>
    <name>A0A2G1XIR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoacylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">D-aminoacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15250</name>
        <name evidence="4" type="ORF">CYQ11_12820</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51127">
        <property type="protein sequence ID" value="PHQ51127"/>
        <property type="gene ID" value="BLA24_15250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13651">
        <property type="protein sequence ID" value="PPT13651"/>
        <property type="gene ID" value="CYQ11_12820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="2">
        <location>
            <begin position="55"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="597" mass="63864" checksum="8204420195C78B05" modified="2018-01-31" version="1">MLDHLIRRATVVDGTGGPSYVADVGIRDGRIAVIDRIPGGVKAGGRLGERARTEEDAAGLVLAPGFVDPHTHYDAQLFWDPCASPSMSHGVTTIVGGNCGFTLAPLNPGRPADADYTRRMMSKVEGMSLAALEEGAPWNWSSFGDYLDALEGRVAVNAGFMVGHCALRRYVMGPDAVGGTPDEEQLRRMLGLLHDAMDAGAWGLSTTRSDTHSDGDGRPVASRHARPGELLALARAVGEHEGTQLEAIVAGCLDRFTEEESELLVRMTVAAGRPLNWNVLTIESAAPERVPHQLATSERARAAGGRIVALTMPVLAPMNMSLGSFCALNLIPGWGDVLGLPVPERVARLRDPAVRTALLSAAASPQAAAFHRLTDFGRYVIGDTYTKENDGLTGREVRDIAAERGTDPFATLVEICATDDLRTVLWPTPTDDDPASWELRRRAWDHEDVLLGGSDAGAHLDRMCGAPYTTRFLGDCLRGRALVPLERAVRMLTDEPARLFGLHDRGRIAEGWCADLVLFDPERVDAGPATLVRDLPGDGARLDSRAVGVVSVRVNGVETVRHDVTTGALPGRVLRSGRDTATVGTGGTGWVAREISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ20</accession>
    <name>A0A2G1XJ20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03915</name>
        <name evidence="2" type="ORF">BLA24_15710</name>
        <name evidence="4" type="ORF">CYQ11_12365</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000057">
        <property type="protein sequence ID" value="PHQ53062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51200">
        <property type="protein sequence ID" value="PHQ51200"/>
        <property type="gene ID" value="BLA24_15710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53062">
        <property type="protein sequence ID" value="PHQ53062"/>
        <property type="gene ID" value="BLA24_03915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13576">
        <property type="protein sequence ID" value="PPT13576"/>
        <property type="gene ID" value="CYQ11_12365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="62" mass="7114" checksum="A74EA1078EABCCB4" modified="2018-01-31" version="1">MGMKDKAEKAKQQAQQKMQDAKQQGQERGQQGQDKVREKGQQGQQRGQQSLDDIQDDLDDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ67</accession>
    <name>A0A2G1XJ67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16250</name>
        <name evidence="2" type="ORF">CYQ11_11825</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51292">
        <property type="protein sequence ID" value="PHQ51292"/>
        <property type="gene ID" value="BLA24_16250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13482">
        <property type="protein sequence ID" value="PPT13482"/>
        <property type="gene ID" value="CYQ11_11825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="20237" checksum="8B7982B6A3E2AB08" modified="2018-01-31" version="1">MPQNVPDFPTLLRSARRTAVHLEMRDSYGVAGEAEEFDQWKRTGEVDLDPESEGWSRWVSLVRETVVRGVVMRRARIVSEPVSEYIRYEHATTAVNVAVGEQVRWLPRRKALGIAVPAADFWLFDDRLVRFNLFTGDGDWADPRFEMTEDPAVVQLCSSAFEAVWERGIPHEEFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJG7</accession>
    <name>A0A2G1XJG7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16265</name>
        <name evidence="2" type="ORF">CYQ11_11810</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51377">
        <property type="protein sequence ID" value="PHQ51377"/>
        <property type="gene ID" value="BLA24_16265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16501">
        <property type="protein sequence ID" value="PPT16501"/>
        <property type="gene ID" value="CYQ11_11810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="161" mass="18099" checksum="5654F215BD0421B9" modified="2018-01-31" version="1">MVATALQTRTRDPRIVLNTVQERVPHLVADVGVDDLWEREVRLLLRDSVAVRSLAERILGQGIAYLITAMENPGVDMGVGYTVDIGVHQLILDTPLYFALCDEYNAGKYKHHAPLIERRRDGTVMRTAEIIRRNGFDVDDELWSVDASDCSPCDNKVPDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJX4</accession>
    <name>A0A2G1XJX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12680</name>
        <name evidence="4" type="ORF">CYQ11_17035</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51554">
        <property type="protein sequence ID" value="PHQ51554"/>
        <property type="gene ID" value="BLA24_12680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14344">
        <property type="protein sequence ID" value="PPT14344"/>
        <property type="gene ID" value="CYQ11_17035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="553" mass="57426" checksum="3E0F9FC3C9941956" modified="2018-01-31" version="1">MAPIPDRGRGPERPERGIPDGLLVSVIAFLMGLTLLVWTATGLAALFAHGAWPDGVTLAHTPQALRRLATQPRDLPSAWPDAGREELSGYGLFWGLLVSEVLVAVVLTTFAIGTVVRWRGVRAREARRAREAAQGRPADSATGPATAEAAGAPGAAATTGVLEAAGMPETPRTAVAQVPETPQAPGTPGSLGASTAPPTPAVPTPAPYTRTTAQVPARAAAGPTAPPPAAATGPQAAPASGTAPRRLVYGTDRRPLATRAVLEAPGPALVVTSDPAVWADTKGARARLGPVHVFDPSHLLDTPDRLRWSPSSGCEARETAASRAAALLAPVRPPSALDSATADAAETLLRCWLHAAAVDGRPFRQVHRWAQGTSAHEPVRILRTNPKAVAGTAGELESALTGHPERRDMAQELTALALNALTSVHIRDACNPNRANSAALESFAAEGGTLYVVGEAIEDPRTRPGAMPLLTALTASVVEHGRRMAERSSSGRLDPPLTLVLEDVAAVAPLPALPELLADGEAQGLPTLALMRSEEQARARWPRRTLPASTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK57</accession>
    <name>A0A2G1XK57_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mshA</name>
        <name evidence="10" type="ORF">BLA24_13030</name>
        <name evidence="11" type="ORF">CYQ11_17390</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51634">
        <property type="protein sequence ID" value="PHQ51634"/>
        <property type="gene ID" value="BLA24_13030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16624">
        <property type="protein sequence ID" value="PPT16624"/>
        <property type="gene ID" value="CYQ11_17390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="9">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="209"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="416" mass="43893" checksum="4C4AFA5381AF9946" modified="2018-01-31" version="1">MLSVHTSPLHQPGTGDAGGMNVYIVELAKRLASINIEVEIFTRATTGTLPPTVELAPGVLVRHIDAGPYEGLAKEELPAQLCAFTHGVMQAWAGHRPGHYDLVHSHYWLSGHVGWLAAQRWGVPLVHAMHTMAKVKNAALAEGDTPEPAARVIGETQIVRAADRLIANTDGEAQELVHHYEADPEKVAVVHPGVNLDRFRPADGRAAARERLGLPPGALVPLFAGRIQPLKAPDVLLRAVAVLLDRQPELRSRIVVPVVGGPSGSGLAKPEGLQKLAARLGVADVVRFRPPVGQERLADWYRAASVLVMPSHSESFGLVAAEAQACGTPVVAAAVGGLPVAVRDGVSGFLIDGHDPADYATALGRFANEPGLADTMGAAAARHAQSFGWGAAAAATAEVYTAAMGERRRRLRSAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKQ9</accession>
    <name>A0A2G1XKQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4142 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11610</name>
        <name evidence="5" type="ORF">CYQ11_02850</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51729">
        <property type="protein sequence ID" value="PHQ51729"/>
        <property type="gene ID" value="BLA24_11610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11977">
        <property type="protein sequence ID" value="PPT11977"/>
        <property type="gene ID" value="CYQ11_02850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304917" evidence="2">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="246" mass="26913" checksum="682893D41351C6BF" modified="2018-01-31" version="1">MRMPHRATTAVAVLVLAGVTAPGTALAGPAGGRAADKDDAVLTKLHQGGMAEVAGGRDARRHAVARCVKDAGRVLVRDHTRMDEQVRKVASRLRVSLPTTTTAEQRKQLKDLRAKARTADYDRLWVKTYGTAHVKTLALLDDEIAHGKNNDVRELARKLRPVVQSHLKMLFQCGAGGHGGRKDQGDQQGGDNGREHGQGNGQGQGRDTGRDNGRDQGRDRTHASSRDHGRTHDRHHRDRHDGHHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL87</accession>
    <name>A0A2G1XL87_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000116">
        <property type="protein sequence ID" value="PHQ51987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51987">
        <property type="protein sequence ID" value="PHQ51987"/>
        <property type="gene ID" value="BLA24_10330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="156" mass="15950" checksum="1BAFD53D1457C033" modified="2018-01-31" version="1">MLVGLFAVAGVLAWAAARLWDSFGTLPSVPVAAPIVLAVIAVVLFATALSLRARLRAQRERRPGAKGVDPLLAARAVVFGQASALVAALVAGMYGGVGVFLLIDGLDTPARRDQAIYTGASVLAAACVVAAAFFMERVCKLPEDDDEDGGAGASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLC9</accession>
    <name>A0A2G1XLC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_07930</name>
        <name evidence="5" type="ORF">BLA24_10405</name>
        <name evidence="6" type="ORF">BLA24_10420</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000119">
        <property type="protein sequence ID" value="PHQ51981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000119">
        <property type="protein sequence ID" value="PHQ51982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51981">
        <property type="protein sequence ID" value="PHQ51981"/>
        <property type="gene ID" value="BLA24_10405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51982">
        <property type="protein sequence ID" value="PHQ51982"/>
        <property type="gene ID" value="BLA24_10420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52370">
        <property type="protein sequence ID" value="PHQ52370"/>
        <property type="gene ID" value="BLA24_07930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_4" evidence="4">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="386" mass="41352" checksum="D7D9F3308794E712" modified="2018-01-31" version="1">MSLTARSFGWPGGCASRKGWGEQLALNEVIEAAQRTDACGELLGYQPHDFRRMFITDAIMNGLPPHIAQVIAGHDDINTTMHYNAVYPSAAIAAHHAFVARRRNLRPGEEYRVPTSEEWEAFLGRFGRRKLSLGPCGRSFGSECVHEHACVRCPVLVVGSEDRGRLDEIRQNLLDRIVEAQVEGWLGEVEGLSYWRTNLTMRQLAPLFGISKSVADRIIDQLGPLIAFQPRRRFAKDTVLVVDGTLGYVGEFRERVSVSAVNASGCGVRVPVSFGSTGGLAVGAWACSVLRGGVDGAEVQGRAVRGGPQGLPCRGVEACRDAQVRRRPPDGAERFGVGLAPAAQEAAAAADPPGPVQTGDRPDAAGGSGHPAQAAAYREACLRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLQ7</accession>
    <name>A0A2G1XLQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">NAD(P)-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_09480</name>
        <name evidence="5" type="ORF">CYQ11_28090</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52140">
        <property type="protein sequence ID" value="PHQ52140"/>
        <property type="gene ID" value="BLA24_09480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16220">
        <property type="protein sequence ID" value="PPT16220"/>
        <property type="gene ID" value="CYQ11_28090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="351" mass="37168" checksum="094FFB0EDB57EE5E" modified="2018-01-31" version="1">MTHNTVAAYAAPAPKAPLERTEIPRRELGAHDILIDIKFAGICHSDIHTARAEWGEGGHFPIVPGHEIAGVVAEVGPGVTRYAPGDRVGVGCFVDSCRECDNCRAGLQQYCTGELGMVGTYNATGRDGQVTQGGYSTHIVVDENYALRVPDGIPLDAAAPLLCAGITLYSPLAHWQAGPGKKVAVVGLGGLGHMGVKLAHAMGAEVTVLSQSLRKKDDGLRLGADHYHATSDPAIFEELAGTFDLILNTVSADLDLDAYLGLLRTGGTLVQLGAPENPLSVSPFALIAARKSFAGSMIGGIRETQEMLDFCGEHGIASEIELIRADQINEAYERVLASDVRYRFVIDTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM88</accession>
    <name>A0A2G1XM88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07695</name>
        <name evidence="2" type="ORF">CYQ11_00125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52333">
        <property type="protein sequence ID" value="PHQ52333"/>
        <property type="gene ID" value="BLA24_07695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11537">
        <property type="protein sequence ID" value="PPT11537"/>
        <property type="gene ID" value="CYQ11_00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="24886" checksum="95A61A4ED62EB23F" modified="2018-01-31" version="1">MKDVLVTGASKGIGWAVSRRLAEEGYGVIGVARSAPDGEFPGTFLRCDLSDVEDTARMLKEVTQGRAVCRVVNNAGIAHPQPIEDLDLAVMHQVVDLNLRASVQIVQALVPDMRAERFGRIVNITSRATYGARDRTSYAAAKSALVGCTRSWALELAPDGITSNAVSPGPTATELFRRARPVGSDGERRAIASIPMGRLGTPDDVAAAVTFLLSDEAGFITGHVLDVDGGSSLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XME5</accession>
    <name>A0A2G1XME5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07755</name>
        <name evidence="3" type="ORF">CYQ11_00185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52341">
        <property type="protein sequence ID" value="PHQ52341"/>
        <property type="gene ID" value="BLA24_07755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11544">
        <property type="protein sequence ID" value="PPT11544"/>
        <property type="gene ID" value="CYQ11_00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="125" mass="13620" checksum="F21C26129454A77A" modified="2018-01-31" version="1">MRDLAQSPEALTKFKDFVAAHGDPEEKEAVGHLTSWKGHRPKGSVDEEARFPAVYPIIMIQSDLPAADWDAADDGDKAQSDLVNEQEGQAAAVAKAFDRWWNGEEKSTVQIFDVRGQLAGSGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMJ7</accession>
    <name>A0A2G1XMJ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GMC family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_06730</name>
        <name evidence="6" type="ORF">CYQ11_26880</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52472">
        <property type="protein sequence ID" value="PHQ52472"/>
        <property type="gene ID" value="BLA24_06730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16005">
        <property type="protein sequence ID" value="PPT16005"/>
        <property type="gene ID" value="CYQ11_26880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="4">
        <location>
            <begin position="439"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="503" mass="52225" checksum="369319632D78977A" modified="2018-01-31" version="1">MAAGGEVVVVGSGFGGAVAALRLAEKGYRVTVLEAGRRFADADFADSPWQAHRVLWAPRLGLTGIVRVRVRRHLLALTGIGVGGGSLAYAGVHHRPAAEVFRRPGWDRTVDWAAELAPFYALAERMMGTAPVPLPAGADTGDGVLGRVAADGGPAGASFRPVRAGVYFGAPGRPVPDPYFAGRGPERTGCTGCARCVLGCRVGAKNTLMKNYLHLAERLGARIRPLTSVIGLVPRPGGGWLVRTVPGGALVPRRRGATFRADQVVLAAGAWGTAELLHRCRAAGTLPGLSAALGSRTLTNREVLLAVSAPGFDVGPGVAVSSELRADDVTLVQLCRVGGGSHPLAALLCPLPGGGARALRRWPVRHFGGRTALLLAMEARESALTSRLRHGRLVLVPADGPREPARLPAAEAAARSFAERVAGSAYGWWWNTLLGLPFTAHLLGGCPIGTDPSTGVVDTGHRVHGHPTLHITDASVVPANLGCNPALTVTALAERAFAAWPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT2</accession>
    <name>A0A2G1XMT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PaaX domain-containing protein, C-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06975</name>
        <name evidence="4" type="ORF">CYQ11_27130</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52513">
        <property type="protein sequence ID" value="PHQ52513"/>
        <property type="gene ID" value="BLA24_06975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16049">
        <property type="protein sequence ID" value="PPT16049"/>
        <property type="gene ID" value="CYQ11_27130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="166"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="27602" checksum="4CD0FFB85202D624" modified="2018-01-31" version="1">MDDSLPLRPLTARSIVLSTLLGHHPPALPARALVRVGELFQTAEGTVRTALTRMVAAGDLEQRDGLYRLTDRLIARQARQDDSRAPRTRPWPGDWEIAVVARERRAAADRAALRQAMTDLRMAELREGCWMRPANLVRDGRPEVVAEQCAVFTGTPEGEPAALAAALWDLDGWARRARALEAALAALPGGPDRLAERFMVSAAVLRHLLADPVLPAELTPEGWPGEGLRSRYDAFDREFRALLLRHIGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMV6</accession>
    <name>A0A2G1XMV6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07400</name>
        <name evidence="4" type="ORF">CYQ11_27555</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52585">
        <property type="protein sequence ID" value="PHQ52585"/>
        <property type="gene ID" value="BLA24_07400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16123">
        <property type="protein sequence ID" value="PPT16123"/>
        <property type="gene ID" value="CYQ11_27555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="338" mass="34820" checksum="C90D78705AA478F8" modified="2018-01-31" version="1">MWPGQQPPGGEQNPQQPNPYQSAGQQQPNPYQQPGYPQQPNPYQQPGGPQPGAFGQPGQPGQPQWQSPAGPPGAPQPGNGKKRGTVIALTAALAVVAAAVVTGVVVLKDDGGDDEGGGGKDQPKAATAPPSAPASPAQGSQGPEDNPRAGGEVKPVVDGWKVVVSSKRHNAFDVPPDWTVNPPTLSTGFEDDKGKPLVIMTSTAMYKKGDCTPTSSRGGAGTKGAQGAKSQESAAEIEAENWVISAFDVKQTGHVETVKAKPFKSDHGLSGQTASATVTGVNKTDKCSTDGKAYTVTYKDTSGDLATWVLYAGTGFSGELPDDTIKKIMSTLRPLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMW7</accession>
    <name>A0A2G1XMW7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbcD</name>
        <name evidence="10" type="ORF">BLA24_07450</name>
        <name evidence="11" type="ORF">CYQ11_27600</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52595">
        <property type="protein sequence ID" value="PHQ52595"/>
        <property type="gene ID" value="BLA24_07450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16132">
        <property type="protein sequence ID" value="PPT16132"/>
        <property type="gene ID" value="CYQ11_27600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="267"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="388" mass="41831" checksum="B5CEB4A7ECC657E4" modified="2018-01-31" version="1">MRILHTSDWHLGRSFHRVGLLGAQRDFLDHLVRTVREARVDAVLVAGDVYDRAVPPLSAVELFDEALHRLADLGVPTVMISGNHDSARRLGVGAGLIERAGIHLRTDPAGCGTPVLLADEHGDVALYGLPYLEPALVREELGATAAGHTAVLEAAMGRVRADLAGRAPGTRSVVLAHAFVAGGASSDSERDITVGGVAAVPPELFAGVDYVALGHLHGCQTITERVRYSGSPLAYSFSEADHRKTMWLVELGADGSLTAERVDCPVPRPLARLRGPLEDLLADPRLERHEDAWVEATLTDPVRPQEPMARLVRRFPHTVSLVFDPDRAPEDPLASYAQRLRGRTDQQIAEDFVAHVRGGQGPDDAERTVLTAALDAVRLDETVREVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX8</accession>
    <name>A0A2G1XMX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ArsR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_07460</name>
        <name evidence="7" type="ORF">CYQ11_27610</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52597">
        <property type="protein sequence ID" value="PHQ52597"/>
        <property type="gene ID" value="BLA24_07460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16134">
        <property type="protein sequence ID" value="PPT16134"/>
        <property type="gene ID" value="CYQ11_27610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="163" mass="17625" checksum="4DD1AC222FC743CA" modified="2018-01-31" version="1">MTGYSPDATDWRILDALQRNGRAGYAELARAVNMSSSAVTERVRRLEEAGIIGGYTAVVDPEKLGMPVLAFVRLRYPNGNYKPFHDLLASTPEILEAHHVTGDDCFVIKVSARSMRHLEEVAGRIGALGSVTTSVVYSSPLPRRAFSRTSPPSGAAQPSRTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN57</accession>
    <name>A0A2G1XN57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000076">
        <property type="protein sequence ID" value="PHQ52643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52643">
        <property type="protein sequence ID" value="PHQ52643"/>
        <property type="gene ID" value="BLA24_06290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="81" mass="8125" checksum="A54F3CA8B556178D" modified="2018-01-31" version="1" fragment="single">MKRASTTPLGALARVSVVIPARNCSRTIQGVVTPVVEDLVAAGAVDEVVVVDHDSVDDTASLAAGAGARVIRFSAAGPIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN79</accession>
    <name>A0A2G1XN79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_06080</name>
        <name evidence="8" type="ORF">CYQ11_03605</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52670">
        <property type="protein sequence ID" value="PHQ52670"/>
        <property type="gene ID" value="BLA24_06080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12104">
        <property type="protein sequence ID" value="PPT12104"/>
        <property type="gene ID" value="CYQ11_03605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="521"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="597" mass="63295" checksum="66DE5335BE3F1E62" modified="2018-01-31" version="1">MSAPVPASDTAPPRDPMARFHQVVAAAPDRVAVLDDSRRLTFAELDRRTARAAALLTARGLGRGALVGVSLPRGADLLVALLAVWRAGAAYVPLDPAYPLDRLVHMVRHANVTTVLTDAGSDVTWPAGVHALALDEAAGTAGGDGPAEVTAGPLDPAYVVFTSGSTGVPKGVRATRGGVAALMAGMEEAGVYADRPRTVAWNASMSFDASVQQWARICRGDTLVTLGESRRTDPARLRELLDEHRVDDLDLTPSHWDLLRETLLAPPADGRRLRLFMGGEPVPDAMWRELGEARARGGLEAVNLYGPTECTVDATAAWIDGPAPHIGRPLPGVVAQVLDGSLRPVPDGEAGELYLAGPQLADGYVGQPALTAQRFVADPFATGRRMYRTGDKVRALPDGTLAYLGRTDRQIKIRGHRVELGEIEAALTGHPDVRAAAVTLHHGAESGDQLIAYYVPGQEAAPGQDGLRDHLAGTLPPYMLPSAYVELAAMPLTVNGKTDTRALPDPAEALAAEARQDAGAAPEGELEILIAGVWGEVLGRDRIRADDDFFALGGHSLLALRVIARLKKQLGLVMPVKEVYQHPRLRSLAERVSALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN87</accession>
    <name>A0A2G1XN87_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05375</name>
        <name evidence="3" type="ORF">CYQ11_01835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52707">
        <property type="protein sequence ID" value="PHQ52707"/>
        <property type="gene ID" value="BLA24_05375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11801">
        <property type="protein sequence ID" value="PPT11801"/>
        <property type="gene ID" value="CYQ11_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="239" mass="25566" checksum="542DA10F9303B3B3" modified="2018-01-31" version="1">MKITVLGTGGGGRAHAAKLLGLGHDVYVGTRDPEATLARTEPDMMGNPPYGRWLADHPGIQLRTFGEAAAAADSLVVGGIDGHNAVAALSSVADQLAGKTLVDYAVPYVYNPQVEHPWPTPWGIMPKLDPCDVDSLGERIQRALPRTKVVKSFVTQEQETVVNPAIVGGGDHTMFVAGDHDDAKRQVTELLKDYGWTDVLDLGPLVCARGMEMYAHMHSAIGFGLGQQFGGRFGIKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP19</accession>
    <name>A0A2G1XP19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Family 65 glycosyl hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 65 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05175</name>
        <name evidence="9" type="ORF">CYQ11_28355</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52941">
        <property type="protein sequence ID" value="PHQ52941"/>
        <property type="gene ID" value="BLA24_05175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11397">
        <property type="protein sequence ID" value="PPT11397"/>
        <property type="gene ID" value="CYQ11_28355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="5">
        <location>
            <begin position="327"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="6">
        <location>
            <begin position="700"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="592"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="793" mass="87587" checksum="AAAF175820766775" modified="2018-01-31" version="1">MITHPAYMVEPWCLRETELNLDVLSQSESVFALSNGHVGWRGNLDEGEPHGLPGSYLNGVYEFRPLPYAEAGYGYPESGQTIINITNGKLIRLLVDDEPFDLRYGKLHKHERVLDFRTGLLHRTTEWTSPSGRSVRVHSTRLVSFTQRAVAAVSYEVEPLDDEMRIVLQSELVANEQLPQHGGDPRAAAVLEAPLEPEQHGAHGPRIRLLHRTARSGLRVAAAAHHFISGGEKTESSSESSEDLARLTVTSRLRPGQRLRMEKIVAHGWSAVRSAPAVHDQVDAALAAAASTGWQGLVRDQRGYLEDFWARADVVVDGDAEIQQAVRFALFHVLQAGARGEARALPAKGLTGPGYDGHCFWDTETFVLPVLTYTAPQAVEQALRWRYSTLAAALERSRQLGFQGAAFPWRTINGSECSGYWPAGTAAFHINADIADAVVRYVRATEDEGFEQEVGLPLLVETARLWRSLGHHDHHGDFHIDGVTGPDEYSAISDDNLYTNLMAQHNLREAAGMVERHPDLAATLGVDDEETAAWRDAAARMTLPFNPELGVHEQSAGFTRHQVWDFSRTGEDRYPLMLNFPYFDLYRKQVVKQADLVLAMCLRGDAFTPEEKARNFAYYEPLTVRDSSLSACGQAVMAAEVGHMRLAYDYLGEAAMMDLSDLEGNTRDGIHIASLAGTWFALVIGFGGMREYDGLLAFTPRLPEQLGRLCFTVQFRERRLRVEITGQTATYTLLEGEDLGIRHCGERLTISAGEPESRQVPPIPAGTPPEQPAGRSPARRGRGAGHGEVDGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP30</accession>
    <name>A0A2G1XP30_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_05230</name>
        <name evidence="6" type="ORF">CYQ11_28300</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52951">
        <property type="protein sequence ID" value="PHQ52951"/>
        <property type="gene ID" value="BLA24_05230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11387">
        <property type="protein sequence ID" value="PPT11387"/>
        <property type="gene ID" value="CYQ11_28300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="24070" checksum="2B440461CC596EA8" modified="2018-01-31" version="1">MEQSQAFSRERPIRVFLLDDHEVVRRGIRDLLDGEDDITVVGEAGGIEHALARGPALRPDVAVLDVRLPDGDGISVCRELRSRLPGLACLMLTSFDDDDALLDAIMAGAAGYVLKQIKGSDLVAAIRTVASGQSMLDPATTARLMSSLRGEDETGPQDARLAGLSPRERDILALVGAGLTNRQIGKELFLSEKTVKNHISRLLAKLGVERRIQAAVIASQAAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP42</accession>
    <name>A0A2G1XP42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05095</name>
        <name evidence="3" type="ORF">CYQ11_28435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52929">
        <property type="protein sequence ID" value="PHQ52929"/>
        <property type="gene ID" value="BLA24_05095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11410">
        <property type="protein sequence ID" value="PPT11410"/>
        <property type="gene ID" value="CYQ11_28435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="233" mass="24738" checksum="BDF24B93D6A20932" modified="2018-01-31" version="1">MSAQPSAPGKGIGAKTVVSWVVSIVCNVALPIVTYNQLTAAGWSEFSALAVSGVWPVVDTVVYLIWHRRVDEFAIVTMIFMALTLVVTAVGPHSTRLLLVKDSAVTGLFGVVCLVSLAAPRPLMFYLGRKFGTDGTKEGVAHWNGLWQHELFRRSLTVITLGWGVGYVAEAVVRVGLSYALATDGMVTVNSVLSYGVPAVLIAWTISYSKRTRARGAQARAEAEAATAAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP49</accession>
    <name>A0A2G1XP49_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_04190</name>
        <name evidence="9" type="ORF">CYQ11_14070</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53025">
        <property type="protein sequence ID" value="PHQ53025"/>
        <property type="gene ID" value="BLA24_04190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13867">
        <property type="protein sequence ID" value="PPT13867"/>
        <property type="gene ID" value="CYQ11_14070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="7">
        <location>
            <begin position="283"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="549" mass="57528" checksum="E55A38EC64CF1B82" modified="2018-01-31" version="1">MNPTAPTHPAYGHVTFLGAGPGDPGLLTLRAVEALAAADVLIADPQVLDVVRTHARSTVDTPAQTVTDEASKAADIPVLRDTANLVMTAARSGKRVVRAVLGDPGLDGNAAEEMLACADAGLTFEVVPGVATAVGVPAYAGVPLRDGQGGDVRFVDARTATAVCWAEAGTSEATTVVSTTLDSVVAAAGELVSGGRKPDTPVSVTAAGTTTRQRTWTATLGTLQQVLKAAKVLPSADGSQPVIAVVGERSAAERRERLSWFESKPLFGWNVLVPRTKEQAASLSDQLRSYGAVPSEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAAVGEQTAKSLIEFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVLSPEPSVHKLAEALAEFGAARRDAAVEAGDPVTRPSERRPGSRRRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPA8</accession>
    <name>A0A2G1XPA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_04040</name>
        <name evidence="8" type="ORF">CYQ11_07275</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53056">
        <property type="protein sequence ID" value="PHQ53056"/>
        <property type="gene ID" value="BLA24_04040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12714">
        <property type="protein sequence ID" value="PPT12714"/>
        <property type="gene ID" value="CYQ11_07275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="5">
        <location>
            <begin position="120"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="6">
        <location>
            <begin position="643"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="770" mass="83902" checksum="585E2E6675416829" modified="2018-01-31" version="1">MAGKPPTGDPVQDAPDVTAPQHAAAGLPAIAHTLRIAQQQMGVRRTALTLLKVNQKDGFDCPGCAWPEPDKRHAAEFCENGAKAVAEEATLRRVTPAFFAAHPVAQLADRSGYWLGQQGRLTEPMYLAEGAEHYEPVSWERAFDIVAEELTALTSPDEAVFYTSGRTSNEAAFLYQLFAREYGTNNLPDCSNMCHESSGSALTETIGIGKGSVLLEDLHKADLIIVAGQNPGTNHPRMLSALEKAKTGGARIITVNPLPEAGLERFKNPQNARGLAGGGTALTDLFLQIRLGGDQALFRLLNKLVLDTDGAVDTDFVREHTHGFEEFARAARAADWDETLRATGLPREDIEAALRMVLASRRTVVCWAMGLTQHKHAVPTIKEVVNFLLLRGNIGRPGAGVCPVRGHSNVQGDRTMGIFERPAPAFLDALEKEFGFAPPREHGLDVVRAIRALRDGAAKVFFAMGGNFVAATPDTDVTEAAIRRARLTVHVSTKLNRSHVITGARALILPTLGRTERDRQASGDQFVTVEDSMGMVHASRGRLEPAGPRLLSEPAIVCRLARRVLGDGSKTPWEAFERDYAAIRDRIARVIPGFEDFNTRVAEPGGFTLPHAPRDSRRFPTTTGKANFTAAAVEYPRVPEGRLLLQTLRSHDQYNTTIYGLDDRYRGIKNGRRVVLLHPDDARDLDLADGAYADLVSEWTDGSERRAPGFRVVHYPTARGCAAAYYPETNVLVPLDHTADTSNTPASKSVVIRIERPHDAPAQDPSPGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPH4</accession>
    <name>A0A2G1XPH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_03385</name>
        <name evidence="7" type="ORF">CYQ11_16900</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53126">
        <property type="protein sequence ID" value="PHQ53126"/>
        <property type="gene ID" value="BLA24_03385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14321">
        <property type="protein sequence ID" value="PPT14321"/>
        <property type="gene ID" value="CYQ11_16900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="25460" checksum="114CD30103A6A07B" modified="2018-01-31" version="1">MADTHVLFVEDDDVIREATQLALERDGFMVTAVPDGLLGLESFRARRPDIALLDVMVPGLDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGAVLVARIRAVLRRFGHASGANGAADGTPETIEGGTLRFGDLEVDTEGMEVRKAGTPVALTPTEMRLLLEFSAAPGTVLSRDRLLERVWDYGWGGDTRVVDVHVQRLRGKIGQDRIETVRGFGYKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPJ2</accession>
    <name>A0A2G1XPJ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02065</name>
        <name evidence="3" type="ORF">CYQ11_04430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53152">
        <property type="protein sequence ID" value="PHQ53152"/>
        <property type="gene ID" value="BLA24_02065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12242">
        <property type="protein sequence ID" value="PPT12242"/>
        <property type="gene ID" value="CYQ11_04430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="308"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="457" mass="48477" checksum="A86B08F7B553EE89" modified="2018-01-31" version="1">MTTDSGTRAGAGTDAAALAAVARTLGEVAGAIREAGRVVTAVSCDPALAASLGRSPRSGLRALRALGGALTAPSGLGYAPDGGRLGRAARLGGLLTGRANLAVDVAVTSLKLRIRLCSARHPEFAEDGLVRRLLEAVEADRQTLALRIFRDGVRAQGADRVLSRLAPSLTEVMAWNALVDENPFNDAAAWHIVTGTRPDGDPLLGLSIGAWARWDRGPGRAVVQPPDAGFLDRLDPGGGIGAHLRNLAVLGNDGRMLVQRVTGPDDVTRYVVLLPGMAFGRPRNPTPQDLVGAVTAVGRNDSPYTRSVRKALVRTVPEGASVALVGHSLGGIAAMNLTEIPQVNQRWRLTHVVAVGSPVDFKRPYDPKTRVVSLVNEHDVVPNLEGRSPVSVFPVPADWLEITWADPSHDFPRCHGAEAYAQGLDEVVPHARDQVDALLAPYRGRVEETVVLRLHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPX5</accession>
    <name>A0A2G1XPX5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">BLA24_02895</name>
        <name evidence="16" type="ORF">CYQ11_05190</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53276">
        <property type="protein sequence ID" value="PHQ53276"/>
        <property type="gene ID" value="BLA24_02895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12371">
        <property type="protein sequence ID" value="PPT12371"/>
        <property type="gene ID" value="CYQ11_05190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ53276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="183" mass="19466" checksum="60D746EF277BE180" modified="2018-01-31" version="1">MRVLGVDPGLTRCGIGVVEGVAGRPLRMRGVGVVRTPADAEVADRLVLIERGIEQWLDEHRPEYVAVERVFSQHNVRTVMGTAQASAVAMLCAARRGLPVALHTPSEVKAAVTGSGRADKAQVGSMVTRLLRLDAPPKPADAADALALAICHIWRAPAAGRLQELAAAHRRTTAPVRLPKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ29</accession>
    <name>A0A2G1XQ29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02410</name>
        <name evidence="2" type="ORF">CYQ11_04775</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53336">
        <property type="protein sequence ID" value="PHQ53336"/>
        <property type="gene ID" value="BLA24_02410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16353">
        <property type="protein sequence ID" value="PPT16353"/>
        <property type="gene ID" value="CYQ11_04775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="25100" checksum="D24F05469DF58427" modified="2018-01-31" version="1">MHMAITGTRPAAPAGIDWVVMRMRGLEAALPPRDGVAVFNRVYLAVTEEVSRGVAGGWFHDRRAAAELDVRFACRYLHAVDQAAVGRRPPACWRPLFQLRGHPAVQPLQFALAGINAHIGHDLALALADTCRALGAEPEALEGDFDRIGDLLASMEERIREELMPGPDLLDVADPLTHLVGSWTLDAARSAAWASFRALWAVRGLPDLAEEFADRVDAGVGMVGRCLLTPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ46</accession>
    <name>A0A2G1XQ46_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000032">
        <property type="protein sequence ID" value="PHQ53356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53356">
        <property type="protein sequence ID" value="PHQ53356"/>
        <property type="gene ID" value="BLA24_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013773757" evidence="1">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="165" mass="17467" checksum="53D48C4229B1C7B4" modified="2018-01-31" version="1">MAAYPAVLWLLTTRAAAAALLPAPLPARAHAAALAVVVGTGAVMSLRGTYGGESADQMLELVFCALLLAALRPTPAAPRLVLWFLALNACLAYATSGIYKVTSGAWRDGTNLTGVLSTRCHGDRRVAAWLTAHPVGAKWLSRGVARGRPSSPWCWWRPRSGCRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQN8</accession>
    <name>A0A2G1XQN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00965</name>
        <name evidence="2" type="ORF">CYQ11_07975</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53533">
        <property type="protein sequence ID" value="PHQ53533"/>
        <property type="gene ID" value="BLA24_00965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12838">
        <property type="protein sequence ID" value="PPT12838"/>
        <property type="gene ID" value="CYQ11_07975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="16368" checksum="DF7791AE258B4439" modified="2018-01-31" version="1">MAEHTSSSITIEATPAQVMAVIADFSRYPEWTGEVKQAEVLDQDDQGRALKVRLVLDAGAIKDDHTLNYSWPEPGVVAWSLDKSQMLRQLDGSYSLEPVAGGAHTKVTYQLTVDVKIPMLGMIKRKAEKVIIDRALEGLKTRVESGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQY1</accession>
    <name>A0A2G1XQY1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_00880</name>
        <name evidence="9" type="ORF">CYQ11_07890</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53569">
        <property type="protein sequence ID" value="PHQ53569"/>
        <property type="gene ID" value="BLA24_00880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16418">
        <property type="protein sequence ID" value="PPT16418"/>
        <property type="gene ID" value="CYQ11_07890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="381"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="448"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="517"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="583"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="649" mass="68083" checksum="E8DEE238E369B274" modified="2018-01-31" version="1">MLDSRYRVEARIAVGGMATVYRAVDTRLDRVLALKVMHPSLAADRAFVDRFIREAKSVARLDHPNVVGVYDQGTDGPYVYLAMEYVAGCTLRDVLRERGALRPRAALDVLEPMLAALGAAHLAGLVHRDVKPENVLIGDDGRVKVADFGLVRAVDTNTSTSTGAVLGTVSYLAPEQIEHGTADTRADVYACGVVLYEMLTGAKPHSGGTPAQVLYQHLHEDVPAPSAAVPSLAPELDALVAAATARDPRLRPADAAALLGRVRAERAELSDEQLDAAAPGAEAGAGAVPAASVASVGSEDRTSVIPRPVTAGPLPPAEDELNRTTRFEAPPVPPASPPGPPPARPAHPARPWQRLPRRWLIAAVAAVVLLLGGTGVWYINSGQFTAVPAVLDMTQDKASQELDRAGLGVKTRQAFSDTVERGRVISTDPEPGKRIRNTGTVTITVSRGPQKAEVPNLAGVQLDDAKRKLQELGLTVGDVTEQFSGETPKGAVLSTDPAPGVERRPGSAVALVVSKGKPRNVPDVTGMSVAAATAALRDAGLETKVADDPVFSTQEKGAVARQSPDRGTQVAEGDTVTVAVSKGKEMATVPDVTGKSEAEAKRILGAAGFQVKVDRPFLFPKDSVDGQSVRAGDQAAKGDTIVIRMKSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XR00</accession>
    <name>A0A2G1XR00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YbjN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00115</name>
        <name evidence="2" type="ORF">BLA24_18665</name>
        <name evidence="4" type="ORF">CYQ11_14615</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000006">
        <property type="protein sequence ID" value="PHQ53589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50794">
        <property type="protein sequence ID" value="PHQ50794"/>
        <property type="gene ID" value="BLA24_18665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53589">
        <property type="protein sequence ID" value="PHQ53589"/>
        <property type="gene ID" value="BLA24_00115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13948">
        <property type="protein sequence ID" value="PPT13948"/>
        <property type="gene ID" value="CYQ11_14615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="20137" checksum="2CCF174BF4C31553" modified="2018-01-31" version="1">MSIDPSSIPNFGGQPEPQPEAGPSGPVIPDQDLVKQLLEQMELKYVVDDEGDLAAPWEQFRTYFMFRGEDEQQVFSVRTFYDRPHGIDEKSKLLEVIDDWNRRTLWPKVYTHTHDDGTVRLIGEAQMLIGVGVSLEHFVSSTVSWVRASIEFDKWLVEQLGLEADIESGDDKPDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X975</accession>
    <name>A0A2G1X975_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30230</name>
        <name evidence="4" type="ORF">CYQ11_23325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47793">
        <property type="protein sequence ID" value="PHQ47793"/>
        <property type="gene ID" value="BLA24_30230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15418">
        <property type="protein sequence ID" value="PPT15418"/>
        <property type="gene ID" value="CYQ11_23325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="11649" checksum="505F2A87D7CF1782" modified="2018-01-31" version="1">MIRRDIPGHRGALGPEISGPGSTASRTRGRKAPPPGLLLPAGRVVLFLLGLVWCWAMYRLLVQPGRAGFVEGLVATGGWGLSLLPVHCVPRTRGRRPRGAHAGSRRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9B3</accession>
    <name>A0A2G1X9B3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_30390</name>
        <name evidence="8" type="ORF">CYQ11_23485</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47824">
        <property type="protein sequence ID" value="PHQ47824"/>
        <property type="gene ID" value="BLA24_30390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15449">
        <property type="protein sequence ID" value="PPT15449"/>
        <property type="gene ID" value="CYQ11_23485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AlcB" evidence="6">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ47824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="28412" checksum="BE7CC7205999EF2E" modified="2018-01-31" version="1">MSTERDDSLLLPPVDAGTPGGHGGAAPFTAGGVGGYASARPDGVDDFTDTVDLRPLAEEFAELLAHEHHAPTLGPGDTGLLDDLASWGPVATPVGPFQLVPVRIERDLPLVTRWMNDPAVAAFWNLSGPDATAGHLRAQLEGDGRSVPCLGVLGGVPMSYWEVYRADLDPIARYYPSRPHDTGIHLVIGKVADRGRGLGTHLLRTVADLVLDRRPSCDRVIAEPDLRNTPCLAAFLGAGFRLTGEVELPDKLAALIVRDRCLRWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9E5</accession>
    <name>A0A2G1X9E5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sucrase ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30550</name>
        <name evidence="2" type="ORF">CYQ11_23645</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47853">
        <property type="protein sequence ID" value="PHQ47853"/>
        <property type="gene ID" value="BLA24_30550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15478">
        <property type="protein sequence ID" value="PPT15478"/>
        <property type="gene ID" value="CYQ11_23645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010350">
        <property type="entry name" value="Aim32/Apd1-like_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030108">
        <property type="entry name" value="Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="PTHR31902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF10">
        <property type="entry name" value="PTHR31902:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035042">
        <property type="entry name" value="UCP035042_thirdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="31450" checksum="DE1F207AE68BB27F" modified="2018-01-31" version="1">MSTCATASRLLTEPLAGTAAPARTWLLIEQPGPWGADALTSSHLAPAVGRALGAAAEGTGVRVALIRRPGRHADCHEPATQRIFVAHTAPGRSWIRTTRVSDPASLLELDLGALGAGEHGGLWEAYEGEPLALVCTNGKRDRCCALLGRPLAAELAASGGTEAWEVTHIGGHRFAPTLFVLPYGYAYGRATAQAVKEVLEAAREGRITTANCRGRSAWERPGQAAELAVRALTGEEGADALDVTGTLGAGPRWSVTVSHTDGRAWRVEVEQGAAEPPRPESCGRALGTPARMDVVAVTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9L6</accession>
    <name>A0A2G1X9L6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30950</name>
        <name evidence="3" type="ORF">CYQ11_24050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47920">
        <property type="protein sequence ID" value="PHQ47920"/>
        <property type="gene ID" value="BLA24_30950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15545">
        <property type="protein sequence ID" value="PPT15545"/>
        <property type="gene ID" value="CYQ11_24050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="276" mass="30920" checksum="D04634ED7704E74A" modified="2018-01-31" version="1">MRRRRLATVLVKLREEAGKSPEDAAERIGCHRSKISRVENARLGISLGEVRDLLRFYGVDDPEYVEEVVNLARRSNERGWTQRLGLRIPSYVDYIDYEETAHYIRSFEPMVISGLLQTADYARALLKATPTMLSNERIDELVEVRMRRQEILRRDAPPRVCVIQGEAALRAQVGGPAVMAAQLKHLVEASEHPNVDLQVLPFAAGAHAGVLGTFVLFSFPTPAFSDIVCLEHRTGTVYLETSEDTGAYTLTFDSLRSTALSPAKSLDVINRVKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9R1</accession>
    <name>A0A2G1X9R1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31330</name>
        <name evidence="2" type="ORF">CYQ11_24370</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47958">
        <property type="protein sequence ID" value="PHQ47958"/>
        <property type="gene ID" value="BLA24_31330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15582">
        <property type="protein sequence ID" value="PPT15582"/>
        <property type="gene ID" value="CYQ11_24370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="13945" checksum="674FF0D959023A18" modified="2018-01-31" version="1">MTLRRTNPAGLSPPTGFTHAVTATGGRLVFLAGQTALDADGTVVGDGLPEQFERALANLLAALRAVGGEPRHLARVTVYATDVGAYRAHARELGAVWRRLAGRDYPAMALVGVTRLWDEEALVELDGTAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Y4</accession>
    <name>A0A2G1X9Y4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31470</name>
        <name evidence="4" type="ORF">CYQ11_24515</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47979">
        <property type="protein sequence ID" value="PHQ47979"/>
        <property type="gene ID" value="BLA24_31470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15604">
        <property type="protein sequence ID" value="PPT15604"/>
        <property type="gene ID" value="CYQ11_24515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305475" evidence="1">
        <location>
            <begin position="28"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="46"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="369" mass="39141" checksum="5F2402F99B2FC2BF" modified="2018-01-31" version="1">MNAHLRRAAVAVAAVSMAAGLAACGSAKEAGDGGDKKKDKKGPLTIGLLLPENQTARYERFDKPLIEKKIKELGGPDVKVLYENAKQDAAVQQQQVDTMITKKVDALIVDAVDAKSIASSVKKANDKGIPVVAYDRLAEGPVKAYTSVDNERVGKIQAESLLKELGDNADKGQIVMMNGAITDPNAKMYKDGAHSVLDGKVKVGKEYDTKEWKPENANENMKGAISSLGKENIVGVYSANDGMAGGIITALRSAGFDKLPPVTGQDAELSAVQRILSDEQFMSVYKPYQPEAEAAASMAVALAQGKGLDSVAKSTVDSGSQKKIPAIIVTPFALTKADIGQYVGKEGFFTLDEICTDKYKAQCDQAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAG9</accession>
    <name>A0A2G1XAG9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xaa-Pro dipeptidyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32910</name>
        <name evidence="5" type="ORF">CYQ11_25960</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48220">
        <property type="protein sequence ID" value="PHQ48220"/>
        <property type="gene ID" value="BLA24_32910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15847">
        <property type="protein sequence ID" value="PPT15847"/>
        <property type="gene ID" value="CYQ11_25960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304561" evidence="2">
        <location>
            <begin position="37"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="3">
        <location>
            <begin position="362"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="662" mass="70331" checksum="B5D555E00B5AB192" modified="2018-01-31" version="1">MPIPVRKPRIPWSTPLLAGLVALLAVLLAPPGAAHAAQDPAGARPPGGSRPVYSYDRAIRETVWVDTGLDGDGDGRADRVAADVIRPREAAEQGRRVPVIMDASPYYSCCGRGNESQRKTYDAQGNPLQFPLYYDNYFVPRGYAVLLTDLTGTNRSDGCTDIGGPSDVQSAKAVVDWLNGRARGYASRTGTGRVGAGWSTGAVGMIGKSYDGTVANAVAATGVKGLKTIVPIGAISSWYDYYFAKGAALFGSGPDGLAAGVESPGARDRCRAVQRRLAEGAPRTGDWTSLWSERDYLDGARKVRASVFAVHGKQDLNVRTKHLGQWWDALAEQGVERKIWLSTAGHVDPFDFRRESWVPTLHRWFDHYLLGYDNGIEREPMADVERAPGQWTTDRVWPPRGTRAATLRPAPGPVPGAGTLGTRPAPYGSTAAFTDDPGRSESDWAATVDRPTPDKVAFTTGPLAHDLRLAGSSSVRLTVTPQAASAHLSAVLVDLGPATIRDYAARGEGIRTLTERTCWGDGTPADTGCFQRTEPAAVSTDHTVFSRGWADLGHYAGLAHGRPLTPGTAYGITLDLAATDHVVPAGHRLALIVAGTDAGLLEPASTTPRLTVDLRRSAVRLPLVGGDDALARATADAGRPQARPTAPLTPYGPRPAGPTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAL2</accession>
    <name>A0A2G1XAL2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48263">
        <property type="protein sequence ID" value="PHQ48263"/>
        <property type="gene ID" value="BLA24_33185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="144" mass="14507" checksum="63B8E4C5D8C8BE0A" modified="2018-01-31" version="1">MLIAGFAFSRLSRKISLNTMLTTGVAICGLGVTGQLAILGTAGETLAGTWASLFVTLLGVGLIFPAATTLGQALGRTAPGAASALLGGLQFLFGALASPLVGLFGETSSTPRALVMLVAVALAALALITLARPWLRHGETLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAL3</accession>
    <name>A0A2G1XAL3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phage tail sheath family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_33210</name>
        <name evidence="6" type="ORF">CYQ11_26260</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48268">
        <property type="protein sequence ID" value="PHQ48268"/>
        <property type="gene ID" value="BLA24_33210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15898">
        <property type="protein sequence ID" value="PPT15898"/>
        <property type="gene ID" value="CYQ11_26260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="3">
        <location>
            <begin position="188"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="4">
        <location>
            <begin position="327"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="440" mass="47515" checksum="2BA010C056652393" modified="2018-01-31" version="1">MTTKPPGVYVTEKSSGVRMIVGVGTSTPAFLGYTTTPTDTPTETGTPPFTPDERRIPQPIRGWQEFADRYSIPALGTELAALLKKETQAAGDLKRIQVLQRCFTLAEAVYGFFANGGTSCYVVGFLNPDVAVAESVLGGNAEERTGLGGLETVPEVTMVAVPSLWDMTVAATDAEAPPAPELRNGKSLIGKVVAHCTAQRNRLAVVDAPPKLLVEPLKEFVDGLDSSDPDAAFTALYYPWVKVPGVDGVPRTVPPSGHLAGVWARTDAERGVFKAPANQNLRGVLDLPVLLSDDQNGELNDRGVNCLRSFPGRGLLVWGARTRSGSRDWRYLNVRRLVSFLSDSIRQSSTWAVFEPNDERLWATLRHSVSSFLTDQWRQGALLGRTPDEAFYVICDRTNNTSSTIDAGQVICDIGIAPVRPAEFVQFTITQIAGQPGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAQ8</accession>
    <name>A0A2G1XAQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Damage-inducible protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30210</name>
        <name evidence="3" type="ORF">CYQ11_23300</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48324">
        <property type="protein sequence ID" value="PHQ48324"/>
        <property type="gene ID" value="BLA24_30210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16748">
        <property type="protein sequence ID" value="PPT16748"/>
        <property type="gene ID" value="CYQ11_23300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="171" mass="17154" checksum="7A0C7920425A61BE" modified="2018-01-31" version="1">MGGSRADEVLAALLERGQSVAAAESLTGGLVAAELTTAPGASRAVRGSVTAYATEVKCDVLGVDEGLLAQRGAVDGEVARQMARGVRTLLRADWGLATTGVAGPERQDGKDVGTVFVAVAGPGGSSSVQELSLNGDRVGIRAESVRAVLALLLRELAGNAGAKDTEQNGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAU9</accession>
    <name>A0A2G1XAU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate carboligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32025</name>
        <name evidence="7" type="ORF">CYQ11_25080</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48358">
        <property type="protein sequence ID" value="PHQ48358"/>
        <property type="gene ID" value="BLA24_32025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16784">
        <property type="protein sequence ID" value="PPT16784"/>
        <property type="gene ID" value="CYQ11_25080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="189"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="387"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="568" mass="61502" checksum="11599949A8117A6E" modified="2018-01-31" version="1">MPAMEAAVHVMKDEGVDIAFGCPGAAILPLYQAMARVGGIEHLIVRHEEGATHMADGWARTNGRVGVALATSGPGATNLVTGLYTAFADSVPMLCVSGQAVSAKLHQEAFQAVDIVDVVRPVTKWAVQVKEAAQVPWVFREAFRTAREGRPGPVLVDIPVDVARREILYDAAADTRLPLRTAEPHPPAVAAALELLLAAERPLVLAGGGVILADAADELRALVEHLRVPFQVTLMGKGVIEDDHELNMGTTGIQTCQRYANASFLESDFVLAVGARFGDRHTGADTAVYKGARTFVHVDVEPTQLGRVIEPDLGVVADAKLFLAALLEAAKRRGATAGGAPWRDRCRHLKRTLTRREDFDTVPVKAPRVYKEINETFGEDTYFVTAIGLYQIWGGQHQKAHRPRHYQVCGQAGPLGWEIPAAIGVKKALEGMGRGGTEVVGVVGDYGFQYMVEELAVAAQYEVPCVLIMLNNEYLGLIRQASIGYGMNYQVDVHYDETGTDNVGLMRAYGCSGRRVTGPADIRPALEWARKEAVSTSRPVLVEIMIEREANTPHGPDIDAVEEFEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAW6</accession>
    <name>A0A2G1XAW6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">BLA24_32300</name>
        <name evidence="11" type="ORF">CYQ11_25355</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48366">
        <property type="protein sequence ID" value="PHQ48366"/>
        <property type="gene ID" value="BLA24_32300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16792">
        <property type="protein sequence ID" value="PPT16792"/>
        <property type="gene ID" value="CYQ11_25355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13317" checksum="264BBDD2C1CFDC28" modified="2018-01-31" version="1">MVCAVSLGGGVGAAARYGASLLCPTVSGAFPWTTLVVNVIGCAVIGVFLVVITDMWAAHRLVRPFLRHRGLGGFTTFSTYVVDILRLADGRRAGLGLVYLAATLCAALAAVWAAAAVTRRAIGWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB84</accession>
    <name>A0A2G1XB84_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase</fullName>
            <shortName evidence="8">L-Cys:GlcN-Ins ligase</shortName>
            <ecNumber evidence="8">6.3.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mycothiol ligase</fullName>
            <shortName evidence="8">MSH ligase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mshC</name>
        <name evidence="10" type="ORF">BLA24_29555</name>
        <name evidence="11" type="ORF">CYQ11_05920</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26176"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48504">
        <property type="protein sequence ID" value="PHQ48504"/>
        <property type="gene ID" value="BLA24_29555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12497">
        <property type="protein sequence ID" value="PPT12497"/>
        <property type="gene ID" value="CYQ11_05920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035446">
        <property type="term" value="F:cysteine-glucosaminylinositol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01697">
        <property type="entry name" value="MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017812">
        <property type="entry name" value="Mycothiol_ligase_MshC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03447">
        <property type="entry name" value="mycothiol_MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="9">
        <location>
            <begin position="39"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'ERGGDP' region" evidence="8">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="409" mass="44172" checksum="B28D961074B62B72" modified="2018-01-31" version="1">MHAWPASEVPALPGSGRDLRIHDTATGERVTLAPGPVARIYVCGITPYDATHMGHAATYNAFDLVQRVWLDTKRQVHYVQNVTDVDDPLLERAVANGDDWTELAERETALFREDMTALRLLPPRHYIGAVESIPKIVPLVERLREAGAAYELEGDTYFSVESDAHFGQVSHYDAEVMRRLSAERGGDPERPGKKNPLDPMLWMAARPGEPSWDGASLGPGRPGWHIECVAIALEHLGMGFDVQGGGSDLIFPHHEMGASHAQALTGEHPFAQAYVHAGMVALHGEKMSKSKGNLVFVSALRRDGVDPAAIRLALLAHHYRADWEWTDAVLTEAVERLDCWRAAVSRPDGPSADALLAEIREALADDLDAPAALAAVDRWAAAQAASGGSDEGAPGLVSRAVDALLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG0</accession>
    <name>A0A2G1XCG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27695</name>
        <name evidence="6" type="ORF">CYQ11_17945</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48849">
        <property type="protein sequence ID" value="PHQ48849"/>
        <property type="gene ID" value="BLA24_27695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14504">
        <property type="protein sequence ID" value="PPT14504"/>
        <property type="gene ID" value="CYQ11_17945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="281" mass="30447" checksum="6F515AAF5B75EE90" modified="2018-01-31" version="1">MSTTDTTQPAETTPATGSRLAARDLTLAYEERTVVEGLDLDVPDGRVTVVVGPNACGKSTLLRALGRLLKPERGAVLLDGEQLARIPTRRIARSLGLLPQTPVAPEAVTVADLVSRGRQPHQRWWRQWSEEDERAVADAMARTDVAELADRPVDELSGGQRQRVWIAMALAQETDLLLLDEPTTYLDVSHQVEVLDLVRRLNHERGRTVVAVLHDLNQAARYADHLVAMKAGRVVAAGRPAEVVTADLVREVFGLESVVVPDPVTGGPLVVPGRPWGGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCN3</accession>
    <name>A0A2G1XCN3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22915</name>
        <name evidence="2" type="ORF">CYQ11_23160</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48961">
        <property type="protein sequence ID" value="PHQ48961"/>
        <property type="gene ID" value="BLA24_22915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15394">
        <property type="protein sequence ID" value="PPT15394"/>
        <property type="gene ID" value="CYQ11_23160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="155" mass="17286" checksum="1FE2A72B55EC1113" modified="2018-01-31" version="1">MKVEHPQDAEARVGRLSSELLDMTQLRGEVTPGGPSPVTFDQKKGKGLYSIQHDWSVWKLSPEELAQGWDRLRDQLAKRGWRITRDGRANSKAQQPQIDAVHEEDHVSLSAELLLRSTRKDDGANGPNASKTDLILFSIVSPTYQAPKGVDPDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCP6</accession>
    <name>A0A2G1XCP6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="6" type="ORF">BLA24_23310</name>
        <name evidence="7" type="ORF">CYQ11_22765</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49027">
        <property type="protein sequence ID" value="PHQ49027"/>
        <property type="gene ID" value="BLA24_23310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15327">
        <property type="protein sequence ID" value="PPT15327"/>
        <property type="gene ID" value="CYQ11_22765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="20992" checksum="A066C755ED4FAA6C" modified="2018-01-31" version="1">MQLVVGRIGRAHGIKGEVTVEVRTDEPELRLGPGAVLATDPAGAGPLTIETGRVHSGRLLLRFAGVADRTAAEALRNTLLIADVDPDETPDDPEEFYDHQLMDLDVVTVDGAAVGRIAEIAHLPSQDLFIVERPDGGEVMIPFVNEIVVEIDLEGQRAVVDPPRGLLDADQAEVASSRDESGTGEDGAARDGDAEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD64</accession>
    <name>A0A2G1XD64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_24150</name>
        <name evidence="8" type="ORF">CYQ11_21925</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49162">
        <property type="protein sequence ID" value="PHQ49162"/>
        <property type="gene ID" value="BLA24_24150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15188">
        <property type="protein sequence ID" value="PPT15188"/>
        <property type="gene ID" value="CYQ11_21925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758481" evidence="5">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="30045" checksum="2ECB893B22D1E958" modified="2018-01-31" version="1">MRPFPARRTRHRLAADAALLTVVLAFAVPLVWLVLASVDDEAGLTVRVPSDPSLDNFSAVMTDEITFTPMLNSLLLCGGATLLTIVCAALAAYPLSRYRSRFARPYLLGVLFTTCLPITAVMVPVYGLFVRVDLIDTLHGTALFLATAQLPFAIWLMKNFMDGVPVILEEAAWTDGASRTQALVRVILPLMGPGLAVVTTYSFLMLWGNFFVPFMLLLSPDQLPASVSIFTFFGNYGQVAYGQLAAFSVLYSTPVILLYALIARRLGGGFALGGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDD9</accession>
    <name>A0A2G1XDD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24650</name>
        <name evidence="4" type="ORF">CYQ11_21420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49254">
        <property type="protein sequence ID" value="PHQ49254"/>
        <property type="gene ID" value="BLA24_24650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15094">
        <property type="protein sequence ID" value="PPT15094"/>
        <property type="gene ID" value="CYQ11_21420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="74"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="334" mass="36953" checksum="CD6337DA80920C15" modified="2018-01-31" version="1">MNDWRIYRGAGLPHDGIRQLPPPPPWRDFASAGPDTGAGTDPSAARRLGVLRRLVENHHPRPEEVEAVNAALYLRRPLLVTGNPGTGKSTLAHAVAHELGLGRVLRWPIVSRSTLRDGLYHYDAIARLQDVQLERAGGAGQERRPIGSYVRLGPLGTALLPTTLPRVLLVDELDKGDLDLPNDLLNALEEGEFRLTELERIADREPEVEVLTDDGERAVIHGGRVRCTTFPLIVLTSNGERDFPAALLRRCIQLNLEPPGEEQLTAMVRAHLGDDAVTGGDALIQRFLDREPGEVIAADQLLNALFLTQHAPRTERVTRDRLADMLMRPLDRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDI9</accession>
    <name>A0A2G1XDI9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-CGNR multi-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24710</name>
        <name evidence="4" type="ORF">CYQ11_21360</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49265">
        <property type="protein sequence ID" value="PHQ49265"/>
        <property type="gene ID" value="BLA24_24710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15083">
        <property type="protein sequence ID" value="PPT15083"/>
        <property type="gene ID" value="CYQ11_21360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="23408" checksum="82B11554B0D17B45" modified="2018-01-31" version="1">MELAYYSDYAVRLVNTEQPARGTDALTSLDAVRALLGPESQAARRLVDGDLTRLRSVRGRLRTVFEAASEGDEVRAVDLLNALLMEFPVSPQISGHEYRDEDGRPKWHMHIADHAANAGAVYTATASMGLAVHLTEYGVDRLGICQAPPCRNAYLDTSTNRSRRYCSDRCATRANVAAYRARKRRESERPAEPATLTGRTAEAAQDSSAPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDR2</accession>
    <name>A0A2G1XDR2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">BLA24_25305</name>
        <name evidence="8" type="ORF">CYQ11_20770</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49368">
        <property type="protein sequence ID" value="PHQ49368"/>
        <property type="gene ID" value="BLA24_25305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14984">
        <property type="protein sequence ID" value="PPT14984"/>
        <property type="gene ID" value="CYQ11_20770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="369" mass="41151" checksum="9646DB7D5D0E44C6" modified="2018-01-31" version="1">MSMIRDLRAAVRPALRRVPVQGGGYDPTRDPSAGSAVVDCAVYRDGKRASSHVSPAEAMRRVRADGGFAWIGLHEPTEHEFAGIAREFGLHPLAVEDAIHAHQRPKLERYDDTLFTVFKTIHYVEHAELTATSEVVETGEVMCFTGPDFIITVRHGGQGSLRALRHRLQDDPQLLGKGPSAVLHAIADQVVDGYIAVADAVQDDIDEVEIDVFSEPSKGSRRGGDAGRIYQLKREVLEFKRAVTPLMRPMQLLSERPMRLVDPDIQKYFRDVADHLARVHEQVVSFDDLLNSILQANLAQASVAQNEDMRKITSWAAIFAVPTMIAGIYGMNFDYMPELHWKYGYPAVMVVTVAICVTIHRGFKRNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDS6</accession>
    <name>A0A2G1XDS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25325</name>
        <name evidence="4" type="ORF">CYQ11_20750</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49372">
        <property type="protein sequence ID" value="PHQ49372"/>
        <property type="gene ID" value="BLA24_25325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14980">
        <property type="protein sequence ID" value="PPT14980"/>
        <property type="gene ID" value="CYQ11_20750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="353"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="432" mass="47260" checksum="113BCB4692EFC041" modified="2018-01-31" version="1">MAAGAARVFVSHLSGVAVFDPNGDQVGRVRDVVAMLRVGGRPPRVLGLVVEVVSRRRIFVPMTRVTGVESGQVITTGVVNMRRFEQRPTETLILGELLDRRVKLVDGGEEVTVLDVSITQLPARRDWEIDKVFVRRGKGGALRRKGEALTVEWSAVTGFSLEEHGQGAENLLATFERLRPADLANVLHHLSPKRRAEVAAALDDDRLADVLEELPEDDQIEILGKLKEERAADVLEAMDPDDAADLLSELPEEEKERLLTLMQPDDAADVRRLLAYEERTAGGLMTTEPIVLRPDATVADALARVRNPDLSPALAAQVYVCRPPDETPTGKYLGTVHFQRLLRDPPFTLVGSLTDTDLRPLPPGTPLPAVTSYLATYNMVSAPVVDDSGSLLGAVTVDDVLDHLLPDDWRETELHYGAPGMSELPEAADGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDZ0</accession>
    <name>A0A2G1XDZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25740</name>
        <name evidence="2" type="ORF">CYQ11_20330</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49446">
        <property type="protein sequence ID" value="PHQ49446"/>
        <property type="gene ID" value="BLA24_25740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14904">
        <property type="protein sequence ID" value="PPT14904"/>
        <property type="gene ID" value="CYQ11_20330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="279" mass="30628" checksum="8FA557FDEE3A469D" modified="2018-01-31" version="1">MTSTTAKHQDFADWINRKAVHAGHPVNVPRASGAAKVAAAVGTTRSSVERILAGHGMPAYRFWPRWAKALNVEYIEFERRASAALNERAEGPTGEPRLIGLAGAAGAGKDEVGRALAVKGWKRRAFADKVKDFLYVMNPLLPDEEDNGAYSLAADVDAFGWDEVKKYPGVRELLQRCGTEAGRHILGPDVWVNALFQGEGEWDAPVVITDVRFPNEARAIKDRGGLVVEVRRPKQILINGADHISENALKDWDFDVIVLNTGTIEDLHKSATCLLPIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE05</accession>
    <name>A0A2G1XE05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25850</name>
        <name evidence="3" type="ORF">CYQ11_20220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49467">
        <property type="protein sequence ID" value="PHQ49467"/>
        <property type="gene ID" value="BLA24_25850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14883">
        <property type="protein sequence ID" value="PPT14883"/>
        <property type="gene ID" value="CYQ11_20220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="103" mass="11983" checksum="04BB4F23E42C652A" modified="2018-01-31" version="1">MAWSTSDRRARLPANWPQIRIRILRRDGHRCTARDQYGVRCSELATDVDHIQPGDDHREANLTSLCGWHHRVKSSREGAAAQAAARRHARRRFRRTERHPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE15</accession>
    <name>A0A2G1XE15_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25770</name>
        <name evidence="2" type="ORF">CYQ11_20300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49452">
        <property type="protein sequence ID" value="PHQ49452"/>
        <property type="gene ID" value="BLA24_25770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14898">
        <property type="protein sequence ID" value="PPT14898"/>
        <property type="gene ID" value="CYQ11_20300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="66" mass="7461" checksum="6202314ABDAB2A1D" modified="2018-01-31" version="1">MTTLTPPTNVVRCVKCIGPIRHIDRKPYECADCGRNVSMADGLIRVGYHWEIVNDWLTSVETVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEA2</accession>
    <name>A0A2G1XEA2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mca</name>
        <name evidence="3" type="ORF">BLA24_26405</name>
        <name evidence="4" type="ORF">CYQ11_19235</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49560">
        <property type="protein sequence ID" value="PHQ49560"/>
        <property type="gene ID" value="BLA24_26405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14720">
        <property type="protein sequence ID" value="PPT14720"/>
        <property type="gene ID" value="CYQ11_19235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="32598" checksum="D88128771FFFEE68" modified="2018-01-31" version="1">MTEQLRMMAVHAHPDDESSKGAATMAKYVSEGVDVLVATCTGGERGSILNPKLQGDPYIEEHIHEVRAKEMAEARDILGVKQEWLGFVDSGLPEGDPLPPLPDGCFALQDVDEAAGELVKLIREFRPHVITTYDENGGYPHPDHIMTHKVSMVAFEAAGDPERYPDAGEPWQPLKLYYNQGFNRPRTQALHEALLERGMESPYGEWLERWHTMGRERTLTTYVPCGEFFEIRDKALIAHATQIDPDGGWFRVPLDLQREVWPTEEYELAKSLVDTSLPEDDLFAGIRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEK1</accession>
    <name>A0A2G1XEK1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_26965</name>
        <name evidence="10" type="ORF">CYQ11_18670</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="6">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49658">
        <property type="protein sequence ID" value="PHQ49658"/>
        <property type="gene ID" value="BLA24_26965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14620">
        <property type="protein sequence ID" value="PPT14620"/>
        <property type="gene ID" value="CYQ11_18670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="28742" checksum="D1B7E345E5D2B7A8" modified="2018-01-31" version="1">MATPTLEKAGTAAQDASPYITVTFRIRRFNPEVSAEATWQDFQVEIDPKERVLDGLHKIKWDLDGTLTFRRSCAHGICGSDAMRINGRNRLACKTLIKDINPEKPITIEAIKGLTVLKDLVVDMDPFFQAYRDVMPFLITKGNEPTRERLQSAEDRERFDDTTKCILCAACTSSCPVFWNDGQYFGPAAIVNAHRFIFDSRDEAGEQRLEILNDKDGVWRCRTTFNCTDACPRGIEVTKAIQEVKRALITRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEK2</accession>
    <name>A0A2G1XEK2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26920</name>
        <name evidence="4" type="ORF">CYQ11_18715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49650">
        <property type="protein sequence ID" value="PHQ49650"/>
        <property type="gene ID" value="BLA24_26920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14628">
        <property type="protein sequence ID" value="PPT14628"/>
        <property type="gene ID" value="CYQ11_18715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="39377" checksum="9A6BDA906F382B95" modified="2018-01-31" version="1">MADDHRYDWLDDDAVERLLRGGNAADDEAGADAGSDQGDHEDRQDAPGATGSADGRPAAAGAVDTAARTGADPDEAAAFAASAERVTAALRALADPAPLRGADPAGPLPGEEAALAAFRAARATTEATAAAAAVAVHPGPVTPEVAHTGRRRPAFAVRSLFRRPVKATLAMALAGCAVGGVAVAAGAGVLPGPFGGGSGEPAPANSVTMADGGAETAGTGSAGASAEPSHGGAHGTRPGETPGTGGTHRPGSPSATPGGRATDGPSATPRRDGKDEKGTDPTREPKLPVGGRDWAARICRDYLASGKRGLSGPGVNEEEARTLERAAGGSALVRAYCEQILGSADTGSGMSGGKKDDGSVWDDLRKGSLPGTPPLNRSQPSLGDPARQPGVTLSGTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEV9</accession>
    <name>A0A2G1XEV9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49767">
        <property type="protein sequence ID" value="PHQ49767"/>
        <property type="gene ID" value="BLA24_27095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="219" mass="23835" checksum="F0416E06EB5B49A4" modified="2018-01-31" version="1" fragment="single">SVEFRQAEFTAIMGPSGSGKSTLMHCMAGLDSVSGGSARIGDTELTALNDKKLTQLRRDKIGFIFQAFNLLPTLTALENITLPMDIAGRKPDRKWLEMVVETVGLSGRLKHRPSQLSGGQQQRVAVARALAGRPEIMFADEPTGNLDSRSGAEVLGFLRNSVRELGQTVVMVTHDPVAASYADRVVFLADGRIVDELHRPTADAVLDRMKRFDAKGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFF2</accession>
    <name>A0A2G1XFF2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20345</name>
        <name evidence="4" type="ORF">CYQ11_10440</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49970">
        <property type="protein sequence ID" value="PHQ49970"/>
        <property type="gene ID" value="BLA24_20345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13253">
        <property type="protein sequence ID" value="PPT13253"/>
        <property type="gene ID" value="CYQ11_10440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="124" mass="13094" checksum="8C6F20180FAA78DB" modified="2018-01-31" version="1">MTLPGDGPARLHGTALRVTVYLGESDTANGRPLYSEIVRRARAAGLAGASVFRGVEGFGASSRVHTSRLLSLSEDLPVAVVIVDTEQHVRGFLPVLEELVGEGLITLDEVEVVRYAGRPGSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFM7</accession>
    <name>A0A2G1XFM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FBP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20585</name>
        <name evidence="3" type="ORF">CYQ11_10195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50011">
        <property type="protein sequence ID" value="PHQ50011"/>
        <property type="gene ID" value="BLA24_20585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13211">
        <property type="protein sequence ID" value="PPT13211"/>
        <property type="gene ID" value="CYQ11_10195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBP_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="18169" checksum="762B24BC57216CBF" modified="2018-01-31" version="1">MEPLGENDIRASFVNCSKGEARRISLPRDLADLPWEDLDFLGWRDPGAPDRGYLVTVRDGKPAGVTLRVPQGGPRSFTKTTMCSLCLTGHPGSGVSLLAARKVGASGRDGNTVGAYICADLACPLYVRGKKVPLMTMRYKESLSVEERVARMRGNVDQFLDKVLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFP0</accession>
    <name>A0A2G1XFP0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20855</name>
        <name evidence="5" type="ORF">CYQ11_09925</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50056">
        <property type="protein sequence ID" value="PHQ50056"/>
        <property type="gene ID" value="BLA24_20855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13165">
        <property type="protein sequence ID" value="PPT13165"/>
        <property type="gene ID" value="CYQ11_09925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="151"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="378" mass="40723" checksum="0A9809EE776D91F5" modified="2018-01-31" version="1">MGTEDRDLLQAVLEALPAGALVQSPTDEVLAVNRRFVDMFDLAGKADLSPGVPMRPLVPLVRAFFSAGFALPHTPGEILARRHAHRVAEIPLTDGRTIRREVEPLRREGAYLGALWLFTDISDAKRSERDLERDNLTLTQLARQRNAFTAAASHELRTPLAAVSSFAELLADPAVGALTAEQSSFLDAIRRNAGRMQRVISDLLLTTRMRASGPELEFAPVDVPGMLTDTLMDHMGEIERARLFAVLDCADGPTLRGDRHRLQHVLGNLLENAAKFTPPGGRITITAAPRGVHWDIEVADTGIGIPDEHRHDIFTGFVRAPNARSGGYPGTGLGLAIARTVVERHGGTITAGGREGEGAVLRLRLPVEGPPPAPGPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFW7</accession>
    <name>A0A2G1XFW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_21345</name>
        <name evidence="9" type="ORF">CYQ11_09440</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50132">
        <property type="protein sequence ID" value="PHQ50132"/>
        <property type="gene ID" value="BLA24_21345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13087">
        <property type="protein sequence ID" value="PPT13087"/>
        <property type="gene ID" value="CYQ11_09440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="296" mass="30636" checksum="B900AA11F0B2EC35" modified="2018-01-31" version="1">MEILELAFMQRALLAALLVGVTAPAIGIYLVQRRQALMGDGIGHVALTGVGLGFLLNTSPVWVATAVCIVGAVVMELIRSYGKARGDIALAMLFYGGMAGGVMLMSLSSNGSSANLTSYLFGSIATVSQEDIVAICLLAAFVVLTTVGLRRQLFAVCQDEEFARVTGLPVRLLNLLVAVTAAVTVTVAMRVVGLLLVSALMVIPVAASQQIARSFATTFAMAVATGVLVTLSGTVTSYYVDVPSGATIVLMAIGVFVALTALATPLARKRAARTARAEHCTLEPEAPGAPADDVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG27</accession>
    <name>A0A2G1XG27_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OsmC family peroxiredoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21535</name>
        <name evidence="2" type="ORF">CYQ11_09250</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50161">
        <property type="protein sequence ID" value="PHQ50161"/>
        <property type="gene ID" value="BLA24_21535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13055">
        <property type="protein sequence ID" value="PPT13055"/>
        <property type="gene ID" value="CYQ11_09250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="141" mass="14435" checksum="BCDB8C7AA7B4F56F" modified="2018-01-31" version="1">MATNRIATTVWEGELLNGSGVVALESSGIGKYPVSWPSRAEQANGKTSPEELIAAAHSSCFSMALSHGLTGAGTPPTRLETKAEVTFQPGEGITGIHLTVRGEVPGLDEEGFAAAAEDAKKNCPVSQALTGTTITLAAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG30</accession>
    <name>A0A2G1XG30_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FmdB family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Zinc ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21750</name>
        <name evidence="3" type="ORF">CYQ11_09035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50200">
        <property type="protein sequence ID" value="PHQ50200"/>
        <property type="gene ID" value="BLA24_21750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13016">
        <property type="protein sequence ID" value="PPT13016"/>
        <property type="gene ID" value="CYQ11_09035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="73" mass="7083" checksum="07682255F37B39E2" modified="2018-01-31" version="1">MPRYEYRCAPCGSTFELNRPMAESSDPATCPDGHTDTVKLLSTVAVTGTAGAGPAPRSGGGGGGGCCGGGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG65</accession>
    <name>A0A2G1XG65_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21725</name>
        <name evidence="4" type="ORF">CYQ11_09060</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50195">
        <property type="protein sequence ID" value="PHQ50195"/>
        <property type="gene ID" value="BLA24_21725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13021">
        <property type="protein sequence ID" value="PPT13021"/>
        <property type="gene ID" value="CYQ11_09060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="33351" checksum="DF3B99724E5AF080" modified="2018-01-31" version="1">MTHAMLKGSNIPLNARTVRAVLRWTPGPGIPDVDASALLLGDGGRVRSDEDFVFYNQPRHPSGLVRHLLKKRQLEGMTDTVEAELGALDASVARVVIAASADGGPFGLVRDLCVLLYDAEQVSAAVAGGTGAAGPTPLARFDVQPETGDETAMLCGELYRRGDGWKFRALGQGYASGLVGLATEFGITVEEGDGTDGARDADGVSASPEAPAAPEPVPDPAVPADEPVTVATSPVAAPGTGHGGYPPPPPMPPVIPPQPSYGYPPYPSAPAVPAAQPAYGYPQQHQSNHSPQPSYGYPPQRPVPDPAFRLPPQGPQFQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGE8</accession>
    <name>A0A2G1XGE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22455</name>
        <name evidence="2" type="ORF">CYQ11_08335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50313">
        <property type="protein sequence ID" value="PHQ50313"/>
        <property type="gene ID" value="BLA24_22455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12900">
        <property type="protein sequence ID" value="PPT12900"/>
        <property type="gene ID" value="CYQ11_08335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="237" mass="25199" checksum="56713E596BB64262" modified="2018-01-31" version="1">MGQPRRGLHTVTGADAVKEVLSRADSVLLDFDGPICHVFAGLPAPSVAQRLRESYTETHGKAAASRLGQTDDPLELVRRAGTKKLPGARRLEAMLTALELEAVNAGEPTPHAREAIQAVHASSRKLAAVSNNSTAALVQYFSEHSLDRYVSPLIGREPEHLTRMKPDPHMVLLALKAHGTAPHRAVVVGDSVTDIQAAHAAGVPCIGYANKPGKAETLKHEGATTVIQDMGELTEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGK3</accession>
    <name>A0A2G1XGK3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22560</name>
        <name evidence="3" type="ORF">CYQ11_08230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50331">
        <property type="protein sequence ID" value="PHQ50331"/>
        <property type="gene ID" value="BLA24_22560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12882">
        <property type="protein sequence ID" value="PPT12882"/>
        <property type="gene ID" value="CYQ11_08230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="486" mass="52939" checksum="6FAEF7728B03DE38" modified="2018-01-31" version="1">MTERPPQRIPNRQLAALIAEAGFSNAGLARRVDQLGLEHGLDLRYDKTSVTRWLRGQQPRGTTPALIAEVFTRRLGRRLSAQDLGLDACAPVYAGLEFAASPEEAIDIVSGLWRKDSGSHTELRKIAFTPAGLVVPSRDWLIGRADERVARGTGPAPSAEGARLPAQARGGVQAPLPRQRLAERAPGSRVSMGDIAALRSVGELFRTLDAAYGGGHARQALVRYLEHETEPMLRGTYGETTGRRLFAAAADLTRLAGWTSFDIAAHGLAQRYYVQALRLAQAAGDRAYGSYVLVTMSRQAVYLGHGREAVQLARVAQQGVGSSAPPVVQSLLHAVEARGHGVLGEVRACSASLARAERALETSRTGEDLPHWARFFDEAELADEFAHCHRDLQQHRAAAQHAERSLQLRSPAYARSRLFCRVVLASARLGLGELEQACALGVEAAQQAAEMRSVRALEYVRDFERRLEPYRDAAAVRAYREKVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGL9</accession>
    <name>A0A2G1XGL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20155</name>
        <name evidence="2" type="ORF">CYQ11_10635</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50372">
        <property type="protein sequence ID" value="PHQ50372"/>
        <property type="gene ID" value="BLA24_20155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13284">
        <property type="protein sequence ID" value="PPT13284"/>
        <property type="gene ID" value="CYQ11_10635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="27989" checksum="65E6B43E02F28FAB" modified="2018-01-31" version="1">MPIPPSRTELIDHLVRTRIAGNVATPRENNLDHYRRLSQGDRNFWFGLELGDRWTDEQDVLAVMAERCGVSDDLGHRAGQDTIDPGLTVAALERAAAFLRKAAEGGQRVLFATGHPGGLLDVHRATAAALRTAGCEIVSIPSGLRADEGSVYQVADVAVYERGATLWHTHSPAPMAAILDGLAALGRPLPDLVVADHGWAGCAAQRGIDAVGYADSNDPALFLAEAEGTLQVTVPLDDHVADPRFYEPMTAYLLDAAGLAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGR8</accession>
    <name>A0A2G1XGR8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ORF">BLA24_22550</name>
        <name evidence="9" type="ORF">CYQ11_08240</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50329">
        <property type="protein sequence ID" value="PHQ50329"/>
        <property type="gene ID" value="BLA24_22550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12884">
        <property type="protein sequence ID" value="PPT12884"/>
        <property type="gene ID" value="CYQ11_08240"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="317" mass="35962" checksum="F60A8F361BE59B11" modified="2018-01-31" version="1">MSAVAPDGRKMLRLEVRNAQTPIERKPEWIKTRAKMGPEYKELHGLVKREGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPQALDRDEPRRVGESVVAMDLNYATITGVARDDLPDGGAWLYAETVRQIHEQTAGREGGRTKVELLAPDFNAVPELLEEVFASRPEVFAHNVETVPRIFKRIRPGFRYERSLDVITQARAYGLVTKSNLILGMGETREEISEALQHLHDAGCELITITQYLRPSVRHHPVERWVKPQEFVELKEEAEEIGYAGVMSGPLVRSSYRAGRLYQQAMDRRSQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGS1</accession>
    <name>A0A2G1XGS1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3494 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_20910</name>
        <name evidence="6" type="ORF">CYQ11_09870</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ice-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50391">
        <property type="protein sequence ID" value="PHQ50391"/>
        <property type="gene ID" value="BLA24_20910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16462">
        <property type="protein sequence ID" value="PPT16462"/>
        <property type="gene ID" value="CYQ11_09870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021884">
        <property type="entry name" value="Ice-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11999">
        <property type="entry name" value="Ice_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304938" evidence="4">
        <location>
            <begin position="27"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="484" mass="48373" checksum="9DFA0CB6457EA56E" modified="2018-01-31" version="1">MAWAAAVLTLALVAAGMALTPTRASAIGVAPNLGTADSYAVLGGQSVTNTGPSTINGDLGVSPGSSVTGFPPGTVNGTIHAADAQAGQAQSDLTIAYDSAAGQAPDATLTSPGDLGGMTLNPGVYKAASSIDITGTLTLDAHGDPNAVWIFQIGSTLETASGSSVSLINGAQPCNVFWQVGSSATIGTDSSFVGTIMALTSISVTTGATIDGRALARNGSTTLDTNTITRESCAAGTGGVIAGTTGGVTGMTTEGTAGMIAGPASGGTTTTGGPTTGGPAGGPTTGGPAGGPTTGGPGGAVAGGLLGGPITGGLLGGPIIGGLIGGTTTGGPGEGHHHHHHHGEDHDHGDHDHGDHDHGDHDHGDHEHGDHEHGDHGDHDHGEDRHHGEGRHHECGRCDHEHGRDHGEGGHHECGRCDHEHGRDHGEGGHHECGRCDHERGRDRQFESCDRRHDGEYGHGGHDGCGHECGRHHPECEDHGRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGS8</accession>
    <name>A0A2G1XGS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22580</name>
        <name evidence="3" type="ORF">CYQ11_08210</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50432">
        <property type="protein sequence ID" value="PHQ50432"/>
        <property type="gene ID" value="BLA24_22580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16425">
        <property type="protein sequence ID" value="PPT16425"/>
        <property type="gene ID" value="CYQ11_08210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="34813" checksum="69910534E422ED03" modified="2018-01-31" version="1">MTAPQDPAAREEKEPAGAGRRTLEGRIALVAGATRGAGRAMAVELGARGAVVYVTGRTTRERRSEVGRAETVEETAELVTAAGGTGVAVPTDHLEPAAVEALARRVDGEQGRLDVLVNDVWGGEHLIEFGKKVWEADLAKGLRMLRLSIDTHAITSHFLTPLLIRRPGGLLVEVTDGTEEFNRTYRENLFYDLAKCAPIRMAFGLAQELEEYGATAVSLTPGFLRSEQMLDHFGVTEANWRDAVSAEPHFAIAESPAYVGRAVAALAADPRRDRWNGRSLSSGELAREYGFTDVDGSRPDAQAYFRDVVFGGKEASAEEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH71</accession>
    <name>A0A2G1XH71_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_17335</name>
        <name evidence="12" type="ORF">CYQ11_15940</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50575">
        <property type="protein sequence ID" value="PHQ50575"/>
        <property type="gene ID" value="BLA24_17335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14171">
        <property type="protein sequence ID" value="PPT14171"/>
        <property type="gene ID" value="CYQ11_15940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="63"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="684" mass="69801" checksum="946205BFE804CA57" modified="2018-01-31" version="1">MTLRRPSPALLALLAATAVLYLWDLSASGYANQFYSAAAQAGGTSWKAFFFGSSDAGNAITVDKPPAALWPMGLAVRLFGLSSWAILVPEALMGVATVGVLYGAVRRSFGRAAGLLAGAVLALTPVAALMFRFNNPDALLCLLTVCAVACVLRALEGARTSWLLAAGLCFGLGFLTKTLQAWLVLPPLALLYAVCAPARPLRRLGQLLLAGLVMVVSGGWWVAVVELWPAASRPYVGGSQHNSFLELTFGYNGLGRINGNETGSVGGGPAGPGGGRWGETGITRLFGSDMGGQIAWLLPAAFVLLVAGLWLTRRAGDEGRARRRALLAWGGSLLMTFLIFSFMSGIFHQYYNVALAPYVAALAGAGAVLLWERRATVLLAGVVVLTVVWAHVLLRRTPHWLPWLKWAVLAGGLVAAALLLLARRRTDRVSARVAGALAVASALAAPLAYTLNTVDTAHGGSIVTAGPAVRGGGFGGGKAGRAGRPGDGFPGGPPGAGGPAGCGGPGGGWGSGVRKGAGPGGRAGAQGDCRPGQDGRRGAGGGAKALPGGPEGGPGGPGGMGGLLGGRRVSAQAVVALKRDAGSYTWAAAAVGSQNAASFQLAAERPVMAVGGFNGSDPSPTVERFRALVEDKEIHYFVASGEGAGRQRGGTGRGYAVEITSWVEAHFTATTVGDVVLYDLTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH78</accession>
    <name>A0A2G1XH78_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17420</name>
        <name evidence="8" type="ORF">CYQ11_15855</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50586">
        <property type="protein sequence ID" value="PHQ50586"/>
        <property type="gene ID" value="BLA24_17420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14159">
        <property type="protein sequence ID" value="PPT14159"/>
        <property type="gene ID" value="CYQ11_15855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="180" mass="20209" checksum="B04728C9DBF923C5" modified="2018-01-31" version="1">MTATATPVCTSASTAAVYPSFTSYVRARGAVLQRTARSLTSNPCDAEDLLQTALTKTYLAWDRIEDHRALDGYVRRALVNTRTSQWRKRRVDEFPCEDLPERETTPAPDPSEQQALRDAMWRAVHRLPDRQRAMVVLRYYEDLTEVQTAELLGVSVGTVKSAVSRALGKLREDPELARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH81</accession>
    <name>A0A2G1XH81_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17465</name>
        <name evidence="4" type="ORF">CYQ11_15810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50592">
        <property type="protein sequence ID" value="PHQ50592"/>
        <property type="gene ID" value="BLA24_17465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14153">
        <property type="protein sequence ID" value="PPT14153"/>
        <property type="gene ID" value="CYQ11_15810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="29"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="318" mass="34999" checksum="C0E0F8B4C0A79F09" modified="2018-01-31" version="1">MRDCARWWHHDAVTYAHRQQDGRSERHPLDVVAHRGASDEAPEHTLAAYRKAIEDGADALECDVRLTADGHLVCVHDRRVNRTSNGRGAVSTLELADLAALDFGSWKATGSEPEAPDRDTERAPGRAPDDPAVPTPGNLPGLAPGSGPDPDRTSVLTLERLLELVADSGRRVELAIETKHPTRWAGRVEERLLTLLDRFGLAAPPRDDPSPVRIMSFSARSLHRVQAAAPGLPTVYLMQFLTPRYRDGRLPTGVGIAGPSIRIVRNHPDYVARLRRAGHQVHVWTVNEPEDVELCVRLGVDAVITNRPKAVLTQLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHA5</accession>
    <name>A0A2G1XHA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FadR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_17565</name>
        <name evidence="6" type="ORF">CYQ11_15710</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50607">
        <property type="protein sequence ID" value="PHQ50607"/>
        <property type="gene ID" value="BLA24_17565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14138">
        <property type="protein sequence ID" value="PPT14138"/>
        <property type="gene ID" value="CYQ11_15710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="25523" checksum="7C52A5D82EA71B41" modified="2018-01-31" version="1">MALRAAGRQSLVDTVVEQLRTQVAAGEWRVGERIPTEHALAEQLQVGRNTVREAVRVLVHAGMLRSRQGEGTFVVSTADPGDILRGLQRAGVRDVLELRIALEAEAARLAALRHEPADLARMRAALDAQTAFEDPDGQPDSGSLELYADHDVEFHKAVVEAAHNPALTATYAWFSSSVREALVTALGDRDMPRIIHGDHHALMEAIASGDPDVAARAARTLLERPKQAVESLLGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHB1</accession>
    <name>A0A2G1XHB1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">BLA24_17640</name>
        <name evidence="15" type="ORF">CYQ11_15635</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50620">
        <property type="protein sequence ID" value="PHQ50620"/>
        <property type="gene ID" value="BLA24_17640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14125">
        <property type="protein sequence ID" value="PPT14125"/>
        <property type="gene ID" value="CYQ11_15635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="75"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ50620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT14125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="32577" checksum="C7D4BCFDC5AF54A8" modified="2018-01-31" version="1">MRGTRFTPDRGLTTRMVSTMFFIGLLYVVFVGVLVALLRGAWPVILVLAGGLFVAQFWFSDRIAAFGMGAREVTPEQAPELHGAVDRLCALADMPKPRVAVADSDVPNAFATGRNQRNALVCATTGLLRRLEPEELEGVLAHELSHVAHRDVAVMTIASFLGVLAGIVTRVGLWGGFRRMGGRDSNTAVLVVLIPLVSAVVYAISFLLTRMLSRYRELSADRAAALLTGRPSALASALTKVTGQMARIPTRDLRQAEPFNAFYFAPAFSKDSMSRLLSSHPTLEQRLEQLGRISAQLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL3</accession>
    <name>A0A2G1XHL3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">dnaA</name>
        <name evidence="15" type="ORF">BLA24_17965</name>
        <name evidence="16" type="ORF">CYQ11_15310</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50681">
        <property type="protein sequence ID" value="PHQ50681"/>
        <property type="gene ID" value="BLA24_17965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14064">
        <property type="protein sequence ID" value="PPT14064"/>
        <property type="gene ID" value="CYQ11_15310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="298"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="512"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="306"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ50681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT14064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="605" mass="66742" checksum="9580186DCEB1E163" modified="2018-01-31" version="1">MADLPADLAAVWPRVLEQLLGEGRGGVESKDEHWIRRCQPLALVADTALLAVPNEFAKGVLEGRLAPVVSETLSRECGRPIRIAITVDDSAGEPPAPQPQENRPPHPHTGGQGRDARDTYEGYEGRGYEGRESYGRPAGGDELPAVRPAYPDYQPPRSEPGAWPRHSAPSGPPAPDRGDYGWQQPRLGSFAEPEHDPYASQYEQQQPDYRSQERPERLPYEQQQRRDLPEPPARGGSRSGGGPASGSSGSGSGGTTPGSGEPTARLNPKYLFDTFVIGASNRFAHAAAVAVAEAPAKAYNPLFIYGESGLGKTHLLHAIGHYARNLYPGTRVRYVSSEEFTNEFINSIRDGKADAFRKRYRDMDILLVDDIQFLASKESTQEEFFHTFNTLHNANKQIVLSSDRPPKQLVTLEDRLRNRFEWGLITDVQPPELETRIAILRKKAVQEQLNAPPEVLEFIASRISRNIRELEGALIRVTAFASLNRQPVDLGLTEIVLKDLIPGGEDASPEITAPAIMAATADYFGHTVEDLCGASRSRVLVTARQIAMYLCRELTDLSLPKIGAQFGGRDHTTVMHADRKIRALMAERRSIYNQVTELTNRIKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHQ4</accession>
    <name>A0A2G1XHQ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uma2 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18460</name>
        <name evidence="3" type="ORF">CYQ11_14820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50760">
        <property type="protein sequence ID" value="PHQ50760"/>
        <property type="gene ID" value="BLA24_18460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13982">
        <property type="protein sequence ID" value="PPT13982"/>
        <property type="gene ID" value="CYQ11_14820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="22437" checksum="D39658D6D369F950" modified="2018-01-31" version="1">MTHSTADRPLIRVEEFEELARQAPETVRLEFINGRIEVKPVPDGDHEEIVRWLQRLCMQHRPDLWLYGARHMKVEAYRKGRAIPDAALAPDGHFKGHGSWSDPDGVLMLVEVTSRDADTNQRDRVDKRDGYAAAGIPVYLLVDRDHHTVTVHWQPEAGEYRCLLTHPFGKPVDLPEPVGFTLETAELGKFTGPAENDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI40</accession>
    <name>A0A2G1XI40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class E sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18060</name>
        <name evidence="4" type="ORF">CYQ11_15215</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50893">
        <property type="protein sequence ID" value="PHQ50893"/>
        <property type="gene ID" value="BLA24_18060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16579">
        <property type="protein sequence ID" value="PPT16579"/>
        <property type="gene ID" value="CYQ11_15215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="25001" checksum="EBE45EA407938F27" modified="2018-01-31" version="1">MDDEIDRLREQWVAGPAAPAPGDPERTPVADPPGDGAAPPRSAPPVPDPALAPVPGPGASAPAPAPAPSPGSPPASAARTGYRSGAPFAVMYIPRLGRGWAKPVLQGTGTELLKKGLGHYERTAGLGESGNFAVAGHRRTYGDPFKDLPDLRPGDAVVLTDGTTWYTYRVDTRPYRTLPTDTDVIAPVPTASGYREPGRYLTLTTCEPEWGHSHRLIVWAHLEGTRPAADGKPKALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI57</accession>
    <name>A0A2G1XI57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_18830</name>
        <name evidence="6" type="ORF">CYQ11_14450</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50916">
        <property type="protein sequence ID" value="PHQ50916"/>
        <property type="gene ID" value="BLA24_18830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16559">
        <property type="protein sequence ID" value="PPT16559"/>
        <property type="gene ID" value="CYQ11_14450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="202" mass="21065" checksum="4B9147007F633E1B" modified="2018-01-31" version="1">MTIRVLLADDEHLIRGALAALLGLEEDLLVVAEAASGPEALAMARAHRPDVAVLDLQMPGTDGVTVATSLRAELPGCRAMIVTGHGRPGHLKRALEAGVRGFVPKTVSARRLAEIIRTVHGGSRYVDPELAADAISAGDSPLTAREAELLELAEDGAPVAEIAERASLTPGTVRNYLSAAAAKLGAENRHAAARIARAQGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIE1</accession>
    <name>A0A2G1XIE1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14490</name>
        <name evidence="3" type="ORF">CYQ11_13585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50996">
        <property type="protein sequence ID" value="PHQ50996"/>
        <property type="gene ID" value="BLA24_14490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13782">
        <property type="protein sequence ID" value="PPT13782"/>
        <property type="gene ID" value="CYQ11_13585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="20483" checksum="66288C8BC6FD48B2" modified="2018-01-31" version="1">MTGIGTGAGTGATALAAAQTHGFLSPSGVEVVFLLVGVVTLGAALVTVTTKQLVHAALWLVVALGGLAVEYLLLSAEFIAWVQVLIYVGSVVVLLLFGLMLTRAPIGRSPDADSGNRWAALAVAVAAAASLVWVVVDAFRTTWIDLRGSPQGSTEVTGEILFRHWVLPFEALSVLLLAALVGAIVLSRKGNREGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ9</accession>
    <name>A0A2G1XIJ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14970</name>
        <name evidence="4" type="ORF">CYQ11_13100</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51078">
        <property type="protein sequence ID" value="PHQ51078"/>
        <property type="gene ID" value="BLA24_14970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13699">
        <property type="protein sequence ID" value="PPT13699"/>
        <property type="gene ID" value="CYQ11_13100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="124"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="418" mass="42852" checksum="B54F3FEC550AFFE9" modified="2018-01-31" version="1">MGEGGDSTATVVTGVTDAARTAGLGAAAWRRGAQVAGAAVGVVAAGAAVGVAVERLTVGRGMRRKARLALDASGPYGTLRGTPGTAVAEDGTPLYYEVDEPDGAERPTRAGRLFGRRPAPPVTVVFTHGYCLSQDAWHFQRAALRGAVRAVFWDQRSHGRSGRAKPAPEGAPVSIDLLGRDLKAVIDAAAPEGPLVLVGHSMGGMTTMALAAQYPELIAERVAGAAFVGTSSGRLSEVTYGLPAAGMSVLRRTVLPGAFKLMAAQTELVEKGRRATADLFAGIIKRYSFGARDIDPAVARFAERLIEATPVDVVAAFYPVFGEHDKLAALSAFAHLPVLVLAGEKDLVIPAEHSKAIADALPEAGLVIVPGAGHMVMMEQPGTVDSHLADLLAAAGAAGAGSPRRGRADRAAGAQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIK1</accession>
    <name>A0A2G1XIK1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">BLA24_14855</name>
        <name evidence="8" type="ORF">CYQ11_13215</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030368392.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51057">
        <property type="protein sequence ID" value="PHQ51057"/>
        <property type="gene ID" value="BLA24_14855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13720">
        <property type="protein sequence ID" value="PPT13720"/>
        <property type="gene ID" value="CYQ11_13215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="154" mass="16684" checksum="12BEE7E75B6D695D" modified="2018-01-31" version="1">MPRPTKGARLGGGAAHEKLMLANLAKSLFEHGRITTTEAKARRLRPVAERLITKAKKGDIHNRRQVLQTITDKGIVHVLFTEIAPRFAERPGGYTRITKIGNRRGDNAPMAVIELVEGEIAKKATVAEAEAATKRAVKESEAAAEAPAEESKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM2</accession>
    <name>A0A2G1XIM2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_14945</name>
        <name evidence="2" type="ORF">CYQ11_13125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51073">
        <property type="protein sequence ID" value="PHQ51073"/>
        <property type="gene ID" value="BLA24_14945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13704">
        <property type="protein sequence ID" value="PPT13704"/>
        <property type="gene ID" value="CYQ11_13125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7614" checksum="C2713756910BCC35" modified="2018-01-31" version="1">MADDGSGSGLERSREWSDPRQAGVVRFFRERAAAASRRRPPRPCAVCAGLGELVLVHEGTPFAVRCVACGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIX4</accession>
    <name>A0A2G1XIX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15335</name>
        <name evidence="3" type="ORF">CYQ11_12740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51141">
        <property type="protein sequence ID" value="PHQ51141"/>
        <property type="gene ID" value="BLA24_15335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13637">
        <property type="protein sequence ID" value="PPT13637"/>
        <property type="gene ID" value="CYQ11_12740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7060" checksum="0377A8FB8D2F26CF" modified="2018-01-31" version="1">MAIQQGKTTWRKSSHSLANGDCVEVASPLPQAIAVRDSKDPQGPALAFTPKAWSSFVATVDGGAYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ27</accession>
    <name>A0A2G1XJ27_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">fbiC</name>
        <name evidence="18" type="ORF">BLA24_15315</name>
        <name evidence="19" type="ORF">CYQ11_12755</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51139">
        <property type="protein sequence ID" value="PHQ51139"/>
        <property type="gene ID" value="BLA24_15315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13639">
        <property type="protein sequence ID" value="PPT13639"/>
        <property type="gene ID" value="CYQ11_12755"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="71"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="530"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PHQ51139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PPT13639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="865" mass="94976" checksum="935E2403C9D17794" modified="2018-01-31" version="1">MTSSAPRSEQSAPTANAMRRALRRARDGVALDVAEAAVLLRARGADLEDLCASAARVRDAGLEAAGRPGVITYSKSVFIPLTRLCRDKCHYCTFATVPGKLRRAGHGMFMSPDEVLAIARRGAELGCKEALITLGDKPEERWPEAREWLEAEGYDDTIAYVRAISIRILEETGLLPHLNPGIMTWTDFQRLKPVSPSMGLMLETTATRLWSEPGGPHYGSPDKEPAVRLRHLEDAGRSSVPLTSGLLLGIGETYEERAESLFALRRVSRAYHGIQELILQNFRAKPDTAMRGMPDAELDELVATVAVARHIMGPSACLQAPPNLVDDEYARLIGAGIDDWGGVSPITPDHVNPERPWPQIEELAERSAAAGFSLRERLCVYPEFIQRGEPWLDPRLLPHVRALADPETGLAREDAVVEGRPWQEPEEVFVPSGRTELHRTIDTEGRTADRRDDFDEVYGDWEALREAAAPGMVPERIDADVRQALKQAADDPTRLTDPEALALLHADGPALDALCRIADDLRRDVVGDDVTYIVTRNINFTNVCYTGCRFCAFAQRRTDADAFTLSLEQVADRAQQAWDVGAVEVCMQGGIHPDLPGTAYFDIARAVKERVPGMHVHAFSPMEVVNGATRTGLSIREWLTAAKEAGLDSIPGTAAEILDDEVRWVLTKGKLPTATWVEVVKTAHELGIRSSSTMMYGHVDQPRHWLGHLRLLAEIQRETGGFTEFVTLPFIHTNAPVYLAGIARPGPTTRDNRAVTAMARLLLHPHIPNIQTSWVKLGTEGAAEMLRSGANDLGGTLMEETISRMAGSSYGSYRSIRDLVAIAETAGRPARARTTLYGEVPRERQEAALTSDGHLPELLPVLGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJM1</accession>
    <name>A0A2G1XJM1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13930</name>
        <name evidence="2" type="ORF">CYQ11_01625</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51426">
        <property type="protein sequence ID" value="PHQ51426"/>
        <property type="gene ID" value="BLA24_13930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11767">
        <property type="protein sequence ID" value="PPT11767"/>
        <property type="gene ID" value="CYQ11_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="15866" checksum="47EF32473B8CEC79" modified="2018-01-31" version="1">MNRFLMEDLMYAAELAARVLDPTDQEERLAEDYTTVLEALSAMDHALREGAWHRMREEADRLMSAAEEVWSTLSATGSELDDVDGTDDVCASADSAKVRQLVAVYAGQHSVGSALHPASVIEDVHLRQAVEDEARLIDPQPVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK84</accession>
    <name>A0A2G1XK84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_12545</name>
        <name evidence="7" type="ORF">CYQ11_17490</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51664">
        <property type="protein sequence ID" value="PHQ51664"/>
        <property type="gene ID" value="BLA24_12545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16626">
        <property type="protein sequence ID" value="PPT16626"/>
        <property type="gene ID" value="CYQ11_17490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="370" mass="39935" checksum="C01A6C4164699DC0" modified="2018-01-31" version="1">MATVTYDKATRIYPGADKPAVDQLDITIEDGEFLVLVGPSGCGKSTSLRMLAGLEDVNGGAIRIGDRDVTHLPPKDRDIAMVFQNYALYPHMTVADNMGFALKIAGVPKAEIRQKVEDAARILDLTEYLGRKPKALSGGQRQRVAMGRAIVREPQVFLMDEPLSNLDAKLRVQTRTQIAGLQRRLGITTVYVTHDQVEAMTMGDRVAVLKDGLLQQVDSPRNMYDRPANLFVAGFIGSPAMNLVEVPITDGGVKFGNSIVPVSREALTTAADKGDRTVTVGVRPEHFEVVERTLEKDGAPAGVAVTVNVVEELGADGYVYGTAELGGEQKDIVVRVGGRRVPEKGSVLHVVPHPGELHVFSTSSGERLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKM2</accession>
    <name>A0A2G1XKM2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12030</name>
        <name evidence="2" type="ORF">CYQ11_03270</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51804">
        <property type="protein sequence ID" value="PHQ51804"/>
        <property type="gene ID" value="BLA24_12030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12050">
        <property type="protein sequence ID" value="PPT12050"/>
        <property type="gene ID" value="CYQ11_03270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046200">
        <property type="entry name" value="DUF6233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19746">
        <property type="entry name" value="DUF6233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="117" mass="13331" checksum="28B306464E3876CD" modified="2018-01-31" version="1">MALLLSRDMEQLFTPDEIVRIEAAAQEAGRTSRDWVREIVLQRVTGEWRHDLEDALWPVTVHRRSGGNLQELHHAGCWVPRGGEDTLTTAEARVKVATLDVRPCDACEPERFLVPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKN7</accession>
    <name>A0A2G1XKN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12025</name>
        <name evidence="3" type="ORF">CYQ11_03265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51803">
        <property type="protein sequence ID" value="PHQ51803"/>
        <property type="gene ID" value="BLA24_12025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12049">
        <property type="protein sequence ID" value="PPT12049"/>
        <property type="gene ID" value="CYQ11_03265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="6923" checksum="5034129A529A70E6" modified="2018-01-31" version="1">MSAFAEAMRKRVRDARAALTAALAAGDVYAAAVAEDELDDALRLAHAHGVPTRDLTGDATTGGESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKQ8</accession>
    <name>A0A2G1XKQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12145</name>
        <name evidence="4" type="ORF">CYQ11_03385</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51823">
        <property type="protein sequence ID" value="PHQ51823"/>
        <property type="gene ID" value="BLA24_12145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12070">
        <property type="protein sequence ID" value="PPT12070"/>
        <property type="gene ID" value="CYQ11_03385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="27611" checksum="2DADBD345B51DD59" modified="2018-01-31" version="1">MTGSDVSPSFRLAYVPGVTPSKWVRIWNERLPDVPLTLVAVSAAEAFGTLRGGDADAGFVRLPVDRTDLSAIPLYTETTVVVVPKDHAVAAVEEVSAEDLADDIVLHPLDDTLEWERLPGRPALERPATTADAVELVAAGVGVLVVPQSLARLHHRKDLTYRPVSDAPVSRVALSWPQEQTTDLVEDFIGIVRGRTVNSTRGRKPAPDQPKDKRPEAGGARRKPAAGKTAGKPGGGRNPRGGSGGTPKGAKRGKPRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKV0</accession>
    <name>A0A2G1XKV0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1929 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12015</name>
        <name evidence="5" type="ORF">CYQ11_03255</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51801">
        <property type="protein sequence ID" value="PHQ51801"/>
        <property type="gene ID" value="BLA24_12015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12047">
        <property type="protein sequence ID" value="PPT12047"/>
        <property type="gene ID" value="CYQ11_03255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304760" evidence="2">
        <location>
            <begin position="32"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1929" evidence="3">
        <location>
            <begin position="560"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="644" mass="69595" checksum="71147108EFA63000" modified="2018-01-31" version="1">MKFPPSAKARRAALGGAAALLLVAANGPAAADFAGRAWHEYTINQESYKERYGHWDVVDVPEEFRINAIHAALLHTGKVLLIAGSGNDEKNFRAGTFQSVLWDPERNTFKQVPTPKDMFCAGHAQLPDGRLLVAGGTARYEKLTGDVKRAGGAMLVKNENPDAPRMLPAGTTFVGGSGKEYRSQFPVLVPRAEKGGDGGGAGGKKVMVTASQARVYVESVVEGEQGITQTADQYRVKGLTGDDARDVYGLAAKLGLDKKDFQGLREAYEFDPVAERYVPVDPMAEARWYPTLVTLRDGRVLTVSGLDDMGEIIYGKNEIYDPRTRTWSPGPNRYFPTYPALFLTGGGKLFYSGSNAGYGPADKGRTPGLWDVDANTFVPVPGLADQEMTETSASVLLPPAQEQKVMIMGGGGVGEAHESSRRTAIADLSDSAPRYVPGPDLPRATRYLNAVLTPDDQVFTTGGSADYRGKRGSDILRAQYYDPRNRVFRPAADPTVGRDYHSEALLLPDGRIAVFGSNPLFADKDDTRTGVFEKRIEVFTPPSLFRGHRPAAVTGPLEAERGETVALPGADPRDVATVRLMRPSAVTHATDVEQRSIALRPASGDGALSVTVPDDPSLVPDGWYMLFVTDREGTPSRAAWVHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKX6</accession>
    <name>A0A2G1XKX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11120</name>
        <name evidence="3" type="ORF">CYQ11_16835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51880">
        <property type="protein sequence ID" value="PHQ51880"/>
        <property type="gene ID" value="BLA24_11120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14309">
        <property type="protein sequence ID" value="PPT14309"/>
        <property type="gene ID" value="CYQ11_16835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="25283" checksum="64988B14F5A53904" modified="2018-01-31" version="1">MAFSADELRVLRRALDIALSPHSVPAGCGPERQAEVRDCLRLAEALAEADRESGRLRAFLLADLSRYRSALPGAAPGYVERLRDALAEGYRPGPEDLAALRSLCTAPSGDAEALRRRELLRHCERLAETAVRARLAVRAAGAVPEARPELGRPRQAADADRGHHLAGAGLEAAGRPGDRPGPPTKPAPGPPPAAPQPKPSSTPKSPRPDRPIPTPGEVFPPRRKPAPPTTALTASRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKZ4</accession>
    <name>A0A2G1XKZ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent Clp protease ATP-binding subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">NDP-hexose 4-ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_11150</name>
        <name evidence="10" type="ORF">CYQ11_16865</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51886">
        <property type="protein sequence ID" value="PHQ51886"/>
        <property type="gene ID" value="BLA24_11150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14315">
        <property type="protein sequence ID" value="PPT14315"/>
        <property type="gene ID" value="CYQ11_16865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="841" mass="92994" checksum="4A3024CA9C820C1C" modified="2018-01-31" version="1">MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEAVRQQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGKEAATAGGPAEGTPSTSLVLDQFGRNLTQAARESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLKDKHLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGATTLDEYRKHLEKDAALERRFQPIQVAEPSLPHTIEILKGLRDRYEAHHRVSITDEALVQAATLADRYISDRFLPDKAIDLIDEAGSRMRIRRMTAPPDLREFDEKIADVRREKESAIDSQDFEKAASLRDKEKQLLAAKAKREKEWKAGDMDVVAEVDGDLIAEVLATATGIPVFKLTEEESSRLLRMEDELHKRVIGQKDAIKALSQAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELSKTLAEFLFGDEDALISLDMSEFSEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEVEKAHPDIFNSLLQILEDGRLTDSQGRVVDFKNTVIIMTTNLGTRDISKGFNLGFAAQGDVKTGYERMKAKVNEELKQHFRPEFLNRVDDTVVFHQLSQEDIIQIVDLMIAKVDERLKDRDMGIELSADAKSLLAKKGYDPILGARPLRRTIQREIEDILSEKILFGELRPGHIVVVGTEGEGEEKKFTFRGEEKSALPDTPPVESAAGGAGPNLSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL49</accession>
    <name>A0A2G1XL49_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabD2</name>
        <name evidence="5" type="ORF">BLA24_10555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000124">
        <property type="protein sequence ID" value="PHQ51968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51968">
        <property type="protein sequence ID" value="PHQ51968"/>
        <property type="gene ID" value="BLA24_10555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="11"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="489" mass="52278" checksum="B4586029EF313514" modified="2018-01-31" version="1">MAVRVPATSWPNCRSRTPEDVAGAFARARQAQRAWAATPVRRRAAVLLRFHDLVLARQSEVLDLIQLETGKARLHAHEEVQAVAVAARHYGHAAPALLRPKGHTGVLPLLTKATELRRPRGVVGQIAPWNYPFELSVGDALPAFAAGNAVVMKPDTQTALTALWARRLLVEAGLPEGVWQVVLGDGPVVGPAVVAHADYVSFTGSTRTGREVARGAAARLVGCSLELGGKNAMLVLRDADVEKAAAGAVRACFSSAGQLCVSIERLYVHSSLADDFLRRFTARTKAMRLGTALAYGADMGSLISARQLETVTRHVEEAVAKGATVLAGGRPRPDVGPFFHEPTILDGVEPPMAVCAEETFGPVVSVYRFDDEDEAVRRANATPYGLNASVWTTDGRRGRALAARLDAGTVNVNEGYAAAYGSARAPMGGMGDSGLGRRHGSEGLLKYTEAQTVAHQRIMPLAPAFGLDDEQYARVMTRGLRLLKAVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL60</accession>
    <name>A0A2G1XL60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10435</name>
        <name evidence="4" type="ORF">BLA24_10440</name>
        <name evidence="2" type="ORF">BLA24_14930</name>
        <name evidence="5" type="ORF">CYQ11_13140</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000120">
        <property type="protein sequence ID" value="PHQ51978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000120">
        <property type="protein sequence ID" value="PHQ51979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51344">
        <property type="protein sequence ID" value="PHQ51344"/>
        <property type="gene ID" value="BLA24_14930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51978">
        <property type="protein sequence ID" value="PHQ51978"/>
        <property type="gene ID" value="BLA24_10435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51979">
        <property type="protein sequence ID" value="PHQ51979"/>
        <property type="gene ID" value="BLA24_10440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13707">
        <property type="protein sequence ID" value="PPT13707"/>
        <property type="gene ID" value="CYQ11_13140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="42827" checksum="AE36E7A39054CD43" modified="2018-01-31" version="1">MPPHHGEHTGARIKRSRKVRRLTQRELAELSNVSYSTLTKVEQGALPASPSVVGALARALSVSVAELNGQPYFEELRQDQLDGLIQPIREALNVYDLGPDPDVVPRPVEELETCAGRLCALVRAANVKQAAADLPGLILEATTTVHTAGSDRSWRLLASMYRTAYDVTTKLSCPDLGMVALDRMGWAAECASDPVLGAVRQYMRGVAYLRAGDYRTGRRLVQLGMAALEQAEPGRERDVATGQLHLGSAVLAGRGNDEATAGAHLEEAQRIADRTGPAEGVHWLSFGPTNVGVHRVSVLAELGQYADAVRAAEKTRIPDGWIPSRLAHHYAEVAQALMWTGRAEAAFKNLQKARKLAPQQTRYHALVRETYAGLESAKRRMPSTFCNFGAWLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLP2</accession>
    <name>A0A2G1XLP2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09255</name>
        <name evidence="2" type="ORF">CYQ11_27865</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52101">
        <property type="protein sequence ID" value="PHQ52101"/>
        <property type="gene ID" value="BLA24_09255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16181">
        <property type="protein sequence ID" value="PPT16181"/>
        <property type="gene ID" value="CYQ11_27865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="344" mass="36556" checksum="D6F3898C4DD7D5A2" modified="2018-01-31" version="1">MPVSTAPGTKWGNWTELEGTVHAEPSAALNSDNRVQAFVRGEDGSLWTIWETRARGWSAWLRHEGARIAGAPSAIRGRDGRIRVFYRTPDHHLEVVAQTAVNTVFGPPQRIVTNVGGDPAATLDADGRIHVFFRGTDGALWYTRNQNLAYATYSGPASLGGALTETPSPALDGSGRIVVAVRGEGDTLHAVQQKAADSADAWDAFQRRAEGVTSRPSAIVDAASRVQIFYRGADGAAWRAGQGDDYEGWGSPASLGGAIADRPTACLGQDGRVNVLAKGTDGKLWVTVQSAGNGAAYDEFQSLGGEIGEVGANPVIMNRVGLLYVFTQGSGEGRGLWLQRQNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLT2</accession>
    <name>A0A2G1XLT2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate racemase</fullName>
            <ecNumber evidence="2">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_08530</name>
        <name evidence="8" type="ORF">CYQ11_03785</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52205">
        <property type="protein sequence ID" value="PHQ52205"/>
        <property type="gene ID" value="BLA24_08530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12138">
        <property type="protein sequence ID" value="PPT12138"/>
        <property type="gene ID" value="CYQ11_03785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="262" mass="26917" checksum="2E7E7BB2E64AD767" modified="2018-01-31" version="1">MKIALMDSGNGLLAAAAVVHQLRPDADLVLSSDPESMPWGPRTPEDVIEHALACARAAAEHRPDALIIACNTASVYALAAIRAELEPGLPVIGTVPAIKPAAADGGPFAIWATPATTGSPYQRGLIREFATGVDVTEVPCPGLADAVQRADTDAVAAAVEAAAARTPRNVRGVVLGCTHYELVAERIRAAVQDPAQPPVKLYGSAKAVVAQALRRIGAAPAPDAAPTGGLTVLFKGREAELEPASLSYPEGRSLPAASPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLX0</accession>
    <name>A0A2G1XLX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08535</name>
        <name evidence="3" type="ORF">CYQ11_03790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52206">
        <property type="protein sequence ID" value="PHQ52206"/>
        <property type="gene ID" value="BLA24_08535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12139">
        <property type="protein sequence ID" value="PPT12139"/>
        <property type="gene ID" value="CYQ11_03790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017832">
        <property type="entry name" value="Glyco_trans_2_hopen-assoc_HpnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03469">
        <property type="entry name" value="HpnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="406" mass="43420" checksum="72F5C009C75D10A6" modified="2018-01-31" version="1">MAVFPRAAGPGCGRLRRVSALTWITVGSLAAWGWLLLGQGFFWRTDVRLPDRTPPADWPAVAIVVPARDEAGVLPSSLPSLLAQDYPGRAEVFLVDDGSSDGTSELARALAARHGGLPLTVDSPGEPGPGWTGKLWAVRHGMALARARTDAEYLLLTDADIAHAPDSLRELVAAARSNGLDLVSQMARLRVASFWERLVVPAFVYFFAQLYPFRRVGRPGARTAAAAGGCVLLRREAAERAGVPERIRQAVIDDVALARAVQRSGGRIWLGLADRVESVRPYPGLASLWRMVSRSAYAQLLHSPLLLAGTVAGLTVVYLVPPVAVVAGALGGAEGALVAGAAAWAVMAGTFAPMLRYYRLPVWWAPLLPVTALLYLLMTVDSAVQHHRGRGAAWKGRTYTRPEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLZ1</accession>
    <name>A0A2G1XLZ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08650</name>
        <name evidence="3" type="ORF">CYQ11_03905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52226">
        <property type="protein sequence ID" value="PHQ52226"/>
        <property type="gene ID" value="BLA24_08650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12159">
        <property type="protein sequence ID" value="PPT12159"/>
        <property type="gene ID" value="CYQ11_03905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="112"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="428" mass="45204" checksum="9436600170CA5AD5" modified="2018-01-31" version="1">MGQQQPVATTFAPSVSERVGASLAGVDAQLARRYPGDPGTRQPVHTVYVPADAFGPATVRSWGEQALAALDEHAPDASAFAHVLGLPDGLAAPVYERVRAKLGREPVEDLRVDFEDGYGARPDAEEDAAAARAARVVARAYADGTAAPYTGVRVKCMEAAVRDRGIRTLDVFLTGLMEAGGLPAGLVLTLPKVTYPEQVTAMVRLTEEFEKAHGLTAGRLRFEVQIETTQSILGADGRATVARLIDAGEGRVTSLHYGTFDYSAACGVSAAHQSPDHPAADHAKAVMQTAAAGTGVRLSDGSTNVLPVGPTEHVHEAWRLHHRLVRRSLARAYYQGWDMHPAHLPTRYAAVYAFYREGLDQAAARLVAYTGRSGGAVLDEPATARALSGHLLRGLDCGALDAGEVTGLTGLGRGALERLAGRPGQDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM41</accession>
    <name>A0A2G1XM41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000089">
        <property type="protein sequence ID" value="PHQ52308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52308">
        <property type="protein sequence ID" value="PHQ52308"/>
        <property type="gene ID" value="BLA24_08345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="66" mass="6805" checksum="3F658E0FD49A3A36" modified="2018-01-31" version="1">MDWFSARTSGAVVARTTGCSPSVLTSVPAGISRSPVLASVRANATVIRAGEAGSGVMPMRRSRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM55</accession>
    <name>A0A2G1XM55_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07715</name>
        <name evidence="4" type="ORF">CYQ11_00145</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52335">
        <property type="protein sequence ID" value="PHQ52335"/>
        <property type="gene ID" value="BLA24_07715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11539">
        <property type="protein sequence ID" value="PPT11539"/>
        <property type="gene ID" value="CYQ11_00145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="279" mass="29728" checksum="55E93DFAF840E7EE" modified="2018-01-31" version="1">MTNVWSTTKTMTALCALVLADRTELDLYAPVAKYWPEFGAAGKDRIEVRHLLSHTAGLPRLGPANDAGRPVRLGEGHRSAGPPAPRWEPGTASGYHRFTHGFLIGEVIRRICQQSIGAYFADQIATRLDADFHIGLAAEHDHRVSDVVPAPGPAPSANPHVAIPVGAYVTAQDTWSTQWRRAAIPTADGYGNARSVAAVQSVLAAGGRRRRGAFFPKQPAARCSTNSPTALISCWAYPSDSAWATPSTPATPQSRQPTPTPATGEGEAGHWSSTISTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMC5</accession>
    <name>A0A2G1XMC5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08915</name>
        <name evidence="2" type="ORF">CYQ11_04170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52289">
        <property type="protein sequence ID" value="PHQ52289"/>
        <property type="gene ID" value="BLA24_08915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16344">
        <property type="protein sequence ID" value="PPT16344"/>
        <property type="gene ID" value="CYQ11_04170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="138" mass="14509" checksum="5601DDC66287846A" modified="2018-01-31" version="1">MDPITLAAGTALVGAIATDGWVQVRETLVGLWRRASPEQADVIDAELVEARAQVLAARQAGEGDAEQVLAAAWQSRLQALLHANPAVAVELRQLLDTRLGGASASEEGVQSGVSVMRAEASGSGRVYQAGRDQHITER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMG6</accession>
    <name>A0A2G1XMG6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52437">
        <property type="protein sequence ID" value="PHQ52437"/>
        <property type="gene ID" value="BLA24_06535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="319" mass="35415" checksum="4557BDCD25852647" modified="2018-01-31" version="1">MQFGISLLPDVEPETRSPVDYYRDVLAMSRLAEELGYSHVKMTEHYLMGYGGYCPSPLNFLSAVAAQTSRIRLFTGCILPVFHHPVKLASYTAMVDAISDGRLDVGFARAYLPYEFETFGVPMDTNRERFESTIETVIKLWTEENVSAETPFFSFRDATTLPRPTQAPHPPVYLSAVRTPESFTRIGELGHGLMITPSGIELNAEQVHRYREAFNAHHGDSGKKPTVVASLPLYVAETDAEAARIADPYLREYLRVWIKSTDSWDNATSKDYPSYTGLSRYLRTLTPGTCASRAAPSSAHPSASPSACAATWRPSRAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMH6</accession>
    <name>A0A2G1XMH6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.174</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2G1835 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase RlmG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmG</name>
        <name evidence="3" type="ORF">BLA24_06585</name>
        <name evidence="4" type="ORF">CYQ11_26735</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10218"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.174"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RlmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.174" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52447">
        <property type="protein sequence ID" value="PHQ52447"/>
        <property type="gene ID" value="BLA24_06585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15979">
        <property type="protein sequence ID" value="PPT15979"/>
        <property type="gene ID" value="CYQ11_26735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052916">
        <property type="term" value="F:23S rRNA (guanine(1835)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01859">
        <property type="entry name" value="23SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017237">
        <property type="entry name" value="rRNA_m2G-MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47816:SF5">
        <property type="entry name" value="PTHR47816:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037565">
        <property type="entry name" value="RRNA_m2G_Mtase_RsmD_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="210"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="384" mass="40928" checksum="4ED4EB7E6D72BC4D" modified="2018-01-31" version="1">MNRFTTPRGDLELARFPEDPRDPLRAWDSADEYLLRHLAGTDGGEPVDLSGSVVVLGDRWGALTTALAGDRPVQITDSFLGQEATRANLARNGVDAGAVRLLSTRDTPPDRVDVLLVRVPKSLALLEDQLHRLAPGVHEGTVVIGTGRVTEIHTSTLQLFERILGPTRTSLAVKKSRLIFCTPDPGIARRPSPWPRSYELGADAGAAAGMTVTNHAGIFCAERLDIGTRFFLGHLPRSGGGRVVDLGCGNGVVGTAAALADPGAELVFVDESFQAVASAEATFRANAGADAKVEFLVGDGLAAVPAGSVDLVLNNPPFHSHQATTDTTAWRMFTGSRRALAPGGELWVVGNRHLGYHVKLRRLFGNCEVVASDPKFVVLRSVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMI1</accession>
    <name>A0A2G1XMI1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsR</name>
        <name evidence="7" type="ORF">BLA24_07805</name>
        <name evidence="8" type="ORF">CYQ11_00235</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52349">
        <property type="protein sequence ID" value="PHQ52349"/>
        <property type="gene ID" value="BLA24_07805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11552">
        <property type="protein sequence ID" value="PPT11552"/>
        <property type="gene ID" value="CYQ11_00235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="78" mass="8998" checksum="EB78EAA8219C3AEB" modified="2018-01-31" version="1">MARRHDPRKPAKSRPNPLDAAGFTYIDYKDTDLLRKFISDRGKIRSRRVTRVTAQQQRALTTAIKNAREMALLPYAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XML9</accession>
    <name>A0A2G1XML9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="14" type="ORF">BLA24_06615</name>
        <name evidence="15" type="ORF">CYQ11_26765</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52453">
        <property type="protein sequence ID" value="PHQ52453"/>
        <property type="gene ID" value="BLA24_06615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15985">
        <property type="protein sequence ID" value="PPT15985"/>
        <property type="gene ID" value="CYQ11_26765"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5033993881" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033993880" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ52453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT15985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="138" mass="14407" checksum="E28FADBDCA7461F0" modified="2018-01-31" version="1">MFRTMMKSKIHRATVTQADLHYVGSLTIDGDLMDAADLLPGEKVDIVDIDNGARLSTYVIEGPRGSGVIGINGAAARLISPGDLVIIIAYGTMDDAEARAFEPRVVFVDEHNAVADLGSDPAAVPEGSGLSRGDLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMN6</accession>
    <name>A0A2G1XMN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA alkylation response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_06970</name>
        <name evidence="11" type="ORF">CYQ11_27125</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52512">
        <property type="protein sequence ID" value="PHQ52512"/>
        <property type="gene ID" value="BLA24_06970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16048">
        <property type="protein sequence ID" value="PPT16048"/>
        <property type="gene ID" value="CYQ11_27125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="177"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="281"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="548" mass="58433" checksum="A114550CF74044A0" modified="2018-01-31" version="1">MSATHEVFNQAPPLTGFSTADDPALLEALRRDGGGWGEAEVRALGARAGSPEVQEWARTAEASPPVLRTHDRYGHRIDEVEFHPSWHRLMAAAVESGQHAAPWAEARPGAHLVRAAKFYVWAQAEPGHGCPVSMTYAAVPALRAQPGLAAAYEPLLASRTYDYGLRPPLGKRGLIAGMSMTEKQGGSDVRANTTTAVPAGDGSYVVTGHKWFTSAPMSDVFLVLAQTGEGLTCFLMPRVLPDGTRNAMRLQRLKDKLGNRSNASAEIEYEQAVAWPVGEPGRGVRTIVEMVNMTRLDCVVGSAAGMRAGLRQALHHASHRRAFGAELIGQPLMRNVLADLAVESEAATVLAMRLAAALDRSEAGDAGEGALRRLGLAAGKYWVCKRGSTHAAEALECLGGNGYVEESGMPRLYREAPLLSIWEGSGNVAALDVLRVLGREPDSLEAYFTEVERAAGADPRLDAALTRLRGLLGELSDPHRAQLLARRLAEQLTLVLQASLLVRHSAPAVADAFCASRLGGDWGNAFGTLPAGADLGPVLDRVLLKDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR8</accession>
    <name>A0A2G1XMR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06725</name>
        <name evidence="3" type="ORF">CYQ11_26875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52471">
        <property type="protein sequence ID" value="PHQ52471"/>
        <property type="gene ID" value="BLA24_06725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16004">
        <property type="protein sequence ID" value="PPT16004"/>
        <property type="gene ID" value="CYQ11_26875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="451" mass="50360" checksum="D27A84E4CE7BB070" modified="2018-01-31" version="1">MTVPKAPAALPLIGHGAHLWFRPMDFMAGAYELGPLVRFRPGRTVSYLITDPGLLHQVLVTEARYVAKGRLTDSAGPQIGVSLVMDMSFEGMTLFASHRRHRRAVQPAFHPHRLAARTDAVVRATRDRLADWWPGRRLRLERELLALSNEVNARAFCGGSATAVARALSGVQAHLNRGLYWRSVAPRWTDGLPVPGTGGFRRARDRLRTAIRDALGERRAHPGYDEGDVLSALARARYADDGSGLGDEQICREMVFYLIAAAHGIGDVLPWVFHELAAHPDAERRLHQELDDVLAGGPVTPEHLPRLEYTRRTLLETLRLYPPVWLLARRTVDALDLGGTVLPAGTELVFSPYAMHRHPHHHAAPLRFDPDRWLPDRRAGLPPCAYVPFGTGPRKCIGDRLSMHQMLTVVATIASRWRLRPVPGVRAYPSARVFLSPRSVEMVCEPRLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMU9</accession>
    <name>A0A2G1XMU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07175</name>
        <name evidence="2" type="ORF">CYQ11_27330</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52546">
        <property type="protein sequence ID" value="PHQ52546"/>
        <property type="gene ID" value="BLA24_07175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16084">
        <property type="protein sequence ID" value="PPT16084"/>
        <property type="gene ID" value="CYQ11_27330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="163" mass="17929" checksum="415F022E9C5DF00C" modified="2018-01-31" version="1">MEITQIRVTEAKARAARLLLAFRHGNQRSFDDSLPSDMAAEETRDLVAALVWVANEAVAKAYRPEAADRVLRHLARRAPEEAGWVETDEEAAPDVAVLLESVWRGDAETVRRLVRATPDTTFLLGKLVHAVALLLPSVPGPEVRRVIGELRGETPPAPRGRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMZ4</accession>
    <name>A0A2G1XMZ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07370</name>
        <name evidence="4" type="ORF">CYQ11_27525</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52580">
        <property type="protein sequence ID" value="PHQ52580"/>
        <property type="gene ID" value="BLA24_07370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16118">
        <property type="protein sequence ID" value="PPT16118"/>
        <property type="gene ID" value="CYQ11_27525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="15695" checksum="DD8CD02BAC3612CD" modified="2018-01-31" version="1">MGTLELRGFSYDGHRTPAPNRRPGAAVQTPNPSRSLAHPETGEIRLEGVLHALSDPMRLLITQELAAAGEAELSCSVFDLPVSKSTTTHHFRVLRESGVVRQVYRGTAKMNSLRRDDLDALFPGLLDSVLSAHAAQTARLGDARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN21</accession>
    <name>A0A2G1XN21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06500</name>
        <name evidence="4" type="ORF">CYQ11_26650</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52610">
        <property type="protein sequence ID" value="PHQ52610"/>
        <property type="gene ID" value="BLA24_06500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16820">
        <property type="protein sequence ID" value="PPT16820"/>
        <property type="gene ID" value="CYQ11_26650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="161"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="819" mass="87777" checksum="B932E1AE0F3F9BE2" modified="2018-01-31" version="1">MTAVVSAMGTVTSGALSGAGGEMGRRSSEALFGLLRRAQRDGGGSGEDRSPGDPGDRGDSGDPGDSGDQGGSPSLPVTEEERRVLADRLADCARRSPEFARDVMRWARESEWLAPRVVPAVAQGASRPRMLPPVTAAFTDRDAVLEEIQQMLDEEERPAGSPAVVVLVGPGGIGKSATAVHCAHALEERFPDGQLHVNLAGAAVSTALAPSEVLARFLDRLGVAPRRMPADERLREELYRDCTADRRMVVVLDDAASASQVRPLLPAAAGALVIVTSRRRLDGLVAGTGARHIVLPPLSPADSVRLLGRIVGRGRMAGREAGARAVAARCGGIPLALCAAGASVAVREHLTFDAVDRRLSAAEYGPDEEAPAVNGGDPADPVRRVNDVTYAELSPRSALLYRMAGAWAWPSVTVAVAAKAAGIGEDEARASLEELAEVHLIEEVGEERYRFHDLVRLHARERAEAEDGHTAVAASVRRVAGWYLGFAAAADLRVVPARWHLGPAYLRLAPPAERGPEDGRAALAALRHERENLAAAVRAAAHHGFDELVWQLCEAMWGLHLRLGFHEQWVESHLLGADAARRCAEQFGDPRAEGRMLVQLAFAHMGLGRLDEAEEALAAAAVTDERAGHHRGRATAVEVLGLLRLRQWRYAEAEERFTEAQRILARVRPGEDGWEDVPRALAILEHHIGRALRGQGLLADATRRLLDALARFRALDVPDLYNEGRVYMSLGETHLDAGEPRLARVCLDRAVSTMGDEGAALQLADAAELRARCARDLAEPAEEAAALRTAEGLYDTAGDHESLARVRARLTELGEGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN74</accession>
    <name>A0A2G1XN74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05345</name>
        <name evidence="4" type="ORF">CYQ11_01805</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52704">
        <property type="protein sequence ID" value="PHQ52704"/>
        <property type="gene ID" value="BLA24_05345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11797">
        <property type="protein sequence ID" value="PPT11797"/>
        <property type="gene ID" value="CYQ11_01805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304937" evidence="2">
        <location>
            <begin position="35"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="233" mass="23842" checksum="8446C0A47122C03C" modified="2018-01-31" version="1">MPGILSTPRRRITVGAVAATTAFAALTGLSHVASASASSSSASPHAAGTDAAPAAGTAAKEKQTGPAKVSGEGRIFYAYSPDDDIRFSVDATAAPFSRPVDQLPKGMPSDARGTVAFSHWVAKTKETRRAEAAVDCLVTAGDTATLTAVITKSADPREIGTRYGFSVKNGGPGKGRFGFHWGVSNVDIVDGKTTAPRVGTCMAPAPFAPVTQGGLKVTHGELPPLPEGWQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNY3</accession>
    <name>A0A2G1XNY3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypB</name>
        <name evidence="4" type="ORF">BLA24_05055</name>
        <name evidence="5" type="ORF">CYQ11_28475</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52923">
        <property type="protein sequence ID" value="PHQ52923"/>
        <property type="gene ID" value="BLA24_05055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11416">
        <property type="protein sequence ID" value="PPT11416"/>
        <property type="gene ID" value="CYQ11_28475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="3">
        <location>
            <begin position="33"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="29156" checksum="738465C0434AF608" modified="2018-01-31" version="1">MCRVIDMRQAVLAKNDALAGAVREELTARGTTVVNLLSSPGSGKTALLERVLLGMRARTVPVAALTADLATENDARRLARAGVPVKQVLTGGLCHLEAAQLRSHLEGWLPADSRVLFVENVGNLVCPAAYDLGETLRVTLMSVTEGEDKPLKYPTAFGLAHLVVLTKTDIAAAVGFDEAAFAANVTRVNPGVPVLATSARDGEGVDAFTDHVLAVAAGTEVHRPRMATGRLGPGKHAGDHQEGYGHGLGPRAHRAHPPGPGPRHAAPGHEPGGPPTVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP71</accession>
    <name>A0A2G1XP71_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BLA24_04435</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000069">
        <property type="protein sequence ID" value="PHQ52991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52991">
        <property type="protein sequence ID" value="PHQ52991"/>
        <property type="gene ID" value="BLA24_04435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLOBIN" evidence="18">
        <location>
            <begin position="165"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="254"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PHQ52991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="490" mass="53375" checksum="1A565F4E789F3A5D" modified="2018-01-31" version="1">MAYERGPYEPQDHPGQYGLQDHPGQHGLQDHPGQEGLQTHTSQHGQQDHPGQYAQPGHPHQGEQREHQRAPEPPDGPPHSPPGGRPAARPQGGWEAPAGPACEAPDRRPASPATPSPDTLLIRRTLAEIEPIADKVTSYFYALLFLQAPGLRALFPAAMDTQRDRLFKALLTAARHADDTATLSAYLSDLGRSHRKYGTEAAHYPAVGESLIGALSRHATATWCEETQAAWVRAYTAISQIMIDAAAEDERTSPAWWHAEIVSHESRTQDVAVVTVRPDQPYPFVAGQYAAVETPWWPRVWRNYSFSCAPRDDGLLSFHIKAVPAGWVSRALVHRAGLGDVIRLGPPNGSMTVDHTTDNGMLCLGGGTGIAPIKALVEDVARHGRSRPVEVFYGARHDDDLYDIDTMLRLQKAHAWLSVRPVVSHGPTLGLSGQLPQVIRKYGPWTAFDAFLSGPPGMIRSGVDTLVGIGIPSHRIRHDSIDDLTASATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP95</accession>
    <name>A0A2G1XP95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_04010</name>
        <name evidence="6" type="ORF">CYQ11_07305</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53052">
        <property type="protein sequence ID" value="PHQ53052"/>
        <property type="gene ID" value="BLA24_04010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12718">
        <property type="protein sequence ID" value="PPT12718"/>
        <property type="gene ID" value="CYQ11_07305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="25594" checksum="0F9AD36648B4BCD9" modified="2018-01-31" version="1">MTALLEIDNLHVAYGKIKAVKGISLTVHTGQIVTLVGTNGAGKTTTLRTISGLLTPHSGTIHFDGQPLTHTPAHRIVARGLAHSPEGRHIFPRLTIAENLHLGAFLRKDTDGITHDIHRVYELFPVLGERSTQKAGTLSGGEQQMLAMGRALMSRPKLLMLDEPSMGLSPIMMQKITATITELKATGTTILLVEQNARAALALADHGHVMETGRIVLSGTGTDLLHDESVRKAYLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPE2</accession>
    <name>A0A2G1XPE2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">QacE family quaternary ammonium compound efflux SMR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_03545</name>
        <name evidence="6" type="ORF">BLA24_24975</name>
        <name evidence="8" type="ORF">CYQ11_21095</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000045">
        <property type="protein sequence ID" value="PHQ53102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49726">
        <property type="protein sequence ID" value="PHQ49726"/>
        <property type="gene ID" value="BLA24_24975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53102">
        <property type="protein sequence ID" value="PHQ53102"/>
        <property type="gene ID" value="BLA24_03545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16701">
        <property type="protein sequence ID" value="PPT16701"/>
        <property type="gene ID" value="CYQ11_21095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="107" mass="11139" checksum="128E7D539B5F0D5F" modified="2018-01-31" version="1">MAWLLVVVAGLLETGFAVCLKLSHGFTRLWPTIAFAAFALGSFGLLTLSLRKLDVGPAYAVWTGIGATGTAIYGMVFLDDLVSALKLVSIAFVIVGVIGLQLSGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPG2</accession>
    <name>A0A2G1XPG2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53135">
        <property type="protein sequence ID" value="PHQ53135"/>
        <property type="gene ID" value="BLA24_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="357" mass="38533" checksum="78070414AF1B570C" modified="2018-01-31" version="1" fragment="single">WGGLYAERLVQGFSGVWHDMNEPVSFAAFGDPTLPRSARHSLEGRGGDHREAHNVYGLAMARAGYEGLCALRPDERPFLFSRSGWAGMQRYGGTWSGDVATGWPGLRASLALVLGLGLCGVPYSGPDIGGFTGSPSPELYVRWFQLGAYLPLFRTHAAISAGRREPWEFGAQALECAGAALRERMRLLPYFVTLAHLARRTGAPYVRPVWWRSPEDRALRDCEDEFLLGDSLLVAPVLERGADQRAVRLPWGRWYDTATGRAYEGPGQVLLDAPLSRVPVLARAGSVIPVAGAGGAVELDVWTPAPGRCGGGVLVPDAGPGWASPEAVRFTTRLRGGAVTVEQEGAAEVRYPVRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPL3</accession>
    <name>A0A2G1XPL3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02070</name>
        <name evidence="4" type="ORF">CYQ11_04435</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53153">
        <property type="protein sequence ID" value="PHQ53153"/>
        <property type="gene ID" value="BLA24_02070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12243">
        <property type="protein sequence ID" value="PPT12243"/>
        <property type="gene ID" value="CYQ11_04435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09818">
        <property type="entry name" value="PIOX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034815">
        <property type="entry name" value="A_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="587" mass="66973" checksum="3E67C7F8DDCA9153" modified="2018-01-31" version="1">MTPAPRPRREWHDLPFPLALWEIRRQRELLRAHNLHDTHGAGGERPRRPSPELLPHRSYDGSGYDPDDLDMGRAGTRFDRNCALPQTFPEAERDGLLAPAPREVSRRLLSRDAGFRPARTLNLLAAAWIQFQNHGWFSHGDNEVDRPLEVPLAPDDDWPQCPMLVRRTRPDPLAHTGTGRPPTYENTVTHWWDGSQVYGSTEERCRALRTGEGGKLAVVDGRLPDERRAGLSGIDATGFNDNYWVGLSLLHTLFAKEHNAICDRIASCHPTWDDERLFHTARLVNAAVMAKIHTVEWTPAVIDQPVTRAAMHVNWYGVLPARLRRRMRRFGRGEALFGIPGSPTRHHAAPYSMTEEFVTSYRLHPLIRDEYEIRSHRTGALIERTGFEPLQALATRKAVDHWGFADLFYSFGSMHPGAITLHNHPDCLRDLARVSGERVDLGTVDVLRDRERGVPRYTAFRAALHRPPVRTFEELTGGDVRLAAELREVYDGRLERVDTMVGMYAEPKPRGFAFSDTAFRVFVLMASRRLKSDRFFTSDYRPEVYTPEGLEWIDRTSMRDVLLRHHPELAPALEGVRNPFAPWAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPM6</accession>
    <name>A0A2G1XPM6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01990</name>
        <name evidence="4" type="ORF">CYQ11_04350</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53141">
        <property type="protein sequence ID" value="PHQ53141"/>
        <property type="gene ID" value="BLA24_01990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12231">
        <property type="protein sequence ID" value="PPT12231"/>
        <property type="gene ID" value="CYQ11_04350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="13670" checksum="D559DD8319CD249E" modified="2018-01-31" version="1">MDLDRDNPSCARRPLWVEEPARRPRMPDPVRDAAVRAGLIVSVTLVVTVVTLLFALSGSWFAFPAVFCAVACTVAATWGVLDVWVTRQVWRQRHGVVSVPSSTARRVHRAQRPGFGPLPRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPP7</accession>
    <name>A0A2G1XPP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02115</name>
        <name evidence="4" type="ORF">CYQ11_04480</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53161">
        <property type="protein sequence ID" value="PHQ53161"/>
        <property type="gene ID" value="BLA24_02115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12252">
        <property type="protein sequence ID" value="PPT12252"/>
        <property type="gene ID" value="CYQ11_04480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="501" mass="52890" checksum="8C3A1566886B7EE3" modified="2018-01-31" version="1">MTQWTSSVGAPQLARLLGSQHARDTVTSLGARRAPAYRSLADGIRLLVLEGRVPVAARLPAERELAAALAVSRTTVAAAYEALRGEGFLESRRGSGSWTAVPAGSPLPSRGLDPLPPEAAASVIDLGCAALTAPEPWLSRAFQGALEELPPYAHTHGDYPAGLPVLRQAIADRYTARGIPTMPEQIMVTTGAMGAVAAICRMMAGRGERVAVESPSYANVLQLMREAGARLVPVAMADGLAGWDLPAWRQVLRDAAPRMAYVIADFHNPTGALAPEEQRRELVEAARAAGTLLVADETMSDLLLDPDVDMPRPVCAFDPAGSAVITVGSASKSFWAGLRIGWVRAAPDVIRGLIAARAYADLATPVFDQLAVTWLLTTDGWDESIAIRRATTRANRDALLASLGRHLPDWEFTVPHGGLTLWVRTGGLSGSRIAEAGERLGVRVPSGPRFGVDGAFEGYVRLPFTVGEAVAEEAAARLAEAARLVASGATAALETPRTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPV7</accession>
    <name>A0A2G1XPV7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">BLA24_02750</name>
        <name evidence="9" type="ORF">CYQ11_05045</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53250">
        <property type="protein sequence ID" value="PHQ53250"/>
        <property type="gene ID" value="BLA24_02750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12343">
        <property type="protein sequence ID" value="PPT12343"/>
        <property type="gene ID" value="CYQ11_05045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="16523" checksum="E7A3E1C3A040F262" modified="2018-01-31" version="1">MAARSKARKRAFQILFEADQRDSTVQNVLADWIRHSRSDDRQPPVNEYTMRLVEGYAEHVARIDELIATYAVDWDLDRMPAADRSIVRLGAYELIWEDETPDAVAIDEAVQLAKEFSTDDSPAFVNGLLGRFKELKPSLRREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQB0</accession>
    <name>A0A2G1XQB0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01580</name>
        <name evidence="4" type="ORF">BLA24_01605</name>
        <name evidence="2" type="ORF">BLA24_23925</name>
        <name evidence="5" type="ORF">CYQ11_22145</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000027">
        <property type="protein sequence ID" value="PHQ53375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000027">
        <property type="protein sequence ID" value="PHQ53381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49707">
        <property type="protein sequence ID" value="PHQ49707"/>
        <property type="gene ID" value="BLA24_23925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53375">
        <property type="protein sequence ID" value="PHQ53375"/>
        <property type="gene ID" value="BLA24_01580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53381">
        <property type="protein sequence ID" value="PHQ53381"/>
        <property type="gene ID" value="BLA24_01605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15225">
        <property type="protein sequence ID" value="PPT15225"/>
        <property type="gene ID" value="CYQ11_22145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="102" mass="10725" checksum="F44235A4E5FCDCB5" modified="2018-01-31" version="1">MSYADLRELQSALSTASDIAFSLGAEPAPHEADQLVDALRRALSAASALGAGGGATGCAEHPKGPVDPLFGDKADPLPPGWGRCLLCNDRRRRASAQRRGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQC1</accession>
    <name>A0A2G1XQC1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAA_hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000023">
        <property type="protein sequence ID" value="PHQ53391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53391">
        <property type="protein sequence ID" value="PHQ53391"/>
        <property type="gene ID" value="BLA24_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="153" mass="16728" checksum="27D28063531E6327" modified="2018-01-31" version="1">MSQSVFSLRGTSTCRPATTVSGPEERGGRVPRPSGTRPTNVPGDTVLVPAAARTAGDRAGRHGGRRTDDEAMAAVAGYALVNDVSEREFQNERGGQWTRARTARPSTRWALAGDRDEIRDPQDLRMRLWVNGALMQDSSTAEQIFPWPSWCAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQF5</accession>
    <name>A0A2G1XQF5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">BLA24_00665</name>
        <name evidence="12" type="ORF">CYQ11_07675</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53477">
        <property type="protein sequence ID" value="PHQ53477"/>
        <property type="gene ID" value="BLA24_00665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12782">
        <property type="protein sequence ID" value="PPT12782"/>
        <property type="gene ID" value="CYQ11_07675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="26547" checksum="50EC98948DF82B65" modified="2018-01-31" version="1">MTLAVRVIPCLDVDNGRVVKGVNFQNLRDAGDPVEMARVYGQEGADELTFLDITASSGNRETTYDVVRRTAEQVFIPLTVGGGVRTAEDVDKLLRAGADKVGVNTAAIERPELIREIAERFGRQVLVLSVDARRTASGSFEVTTHGGRRGTGVDAVEWAHRAAELGAGEILLNSMDADGTKDGYDTEMIAAVRRHVTVPVIASGGAGKLADFAPAVDAGADAVLAASVFHFGDLRIAEVKGALRDAGHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ3</accession>
    <name>A0A2G1XQJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine oxidase ThiO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiO</name>
        <name evidence="3" type="ORF">BLA24_00865</name>
        <name evidence="4" type="ORF">CYQ11_07875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53515">
        <property type="protein sequence ID" value="PHQ53515"/>
        <property type="gene ID" value="BLA24_00865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12820">
        <property type="protein sequence ID" value="PPT12820"/>
        <property type="gene ID" value="CYQ11_07875"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="18"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="41980" checksum="978488BAEF6DCC2B" modified="2018-01-31" version="1">MHAHRTPAHPTHAHHTYDVLVIGGGVIGLVTAWRAAQRGLRTAVADPAPGGGAAQVAAGMLAAVTELHYGEQDLLALNLASARRYPQFTAELEEATGRDTGYRACGTLAVALDADDRAHLRELHDLQQRSGLDSQWLTGRECRRLEPMLAPGVRGGLHALGDHQTDPRRLAGALLTACERAGVALHRSAAVRALLSGDRAAGAELADGTRVAAGQTVLAAGSHSGRLEGLPPDVLPPVRPVKGQILRLRVPEAYRPFLSRTVRAVVRGGHVYLVPRENGELVVGATTEELGWDTTVTAGGVYELLRDAHELVPGITELPLVETRAGLRPCSPDNAPLLGPTRLPGLLAATGHHRNGVLLAPLTGDVMAEVLTTGRLPDEALPFSPQRFTPVLQEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQM3</accession>
    <name>A0A2G1XQM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF2029 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_00985</name>
        <name evidence="10" type="ORF">CYQ11_07995</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53536">
        <property type="protein sequence ID" value="PHQ53536"/>
        <property type="gene ID" value="BLA24_00985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12841">
        <property type="protein sequence ID" value="PPT12841"/>
        <property type="gene ID" value="CYQ11_07995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="413" mass="45012" checksum="6904784AAAE27A64" modified="2018-01-31" version="1">MVAGTGLRLSIVAWALTRAVLLLCVFRVWILPGSDVSVDIEVIYQGWYGVLRTGIFPYDDVTWQYPPAAALAVLAPGLVPFLDYAPAFFVLCFLADVAVMGMLLYAVRDGRRSAWGVWVWVVGVPLLGPIVYARYDVMVTAVAVAALLAARRRTRLAGALVGFGALLKVWPVLLLAGSPRGPRTRTLWGSALLTAMGLAMFFAAAMPGALAFLTFQRHRGTEVESLGSLVFHLGRHLGWHGKARLNYGSVEFLGRHVHAVSFLALGLSVLAFAWLLLWRVRARRFTATTPYDAAFAAVLLFTTTSRVISPQYMIWLIGLAAVCVTMRTPRQGLPVVLVLLATPLTQLEFPIWFSHVVASDKLGVATLTLRNGLLVAATVLACARLWRETVTEDHPSQEEPEPPAEKESALVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQM9</accession>
    <name>A0A2G1XQM9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="10">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp</name>
        <name evidence="12" type="ORF">BLA24_00915</name>
        <name evidence="13" type="ORF">CYQ11_07925</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53523">
        <property type="protein sequence ID" value="PHQ53523"/>
        <property type="gene ID" value="BLA24_00915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12828">
        <property type="protein sequence ID" value="PPT12828"/>
        <property type="gene ID" value="CYQ11_07925"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ53523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT12828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="343" mass="36679" checksum="176A960461093795" modified="2018-01-31" version="1">MRIGVLTGGGDCPGLNAVIRAVVRKGVQDYDHDFIGFRDGWRGPLHGTVVPLGIPAVRGILPRGGTILGSSRTNPLKEADGVRRIKENLAAHEVDALIAIGGEDTLGVAARLHDEHGVRCVGVPKTIDNDLSATDYTFGFDTAVNIATEAIDRLHTTAESHMRVLVVEVMGRHAGWIALHSGLAGGANVILVPERPFDLDEVCDWVTSRFRASYAPIVVVAEGAVPKDGDLVLKNASARDSFGHVRLSGVGEWLAEEIERRTGKEARTTVLGHVQRGGTPSAFDRWLATRFGLHAIEAVDDGAFGSMVALRGPDIVRVPLAEATARIKTVPAALYEEARVFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQV5</accession>
    <name>A0A2G1XQV5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01005</name>
        <name evidence="4" type="ORF">CYQ11_08015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53539">
        <property type="protein sequence ID" value="PHQ53539"/>
        <property type="gene ID" value="BLA24_01005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12844">
        <property type="protein sequence ID" value="PPT12844"/>
        <property type="gene ID" value="CYQ11_08015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="457" mass="48560" checksum="7184C333A35B6194" modified="2018-01-31" version="1">MVEHTDGAEAAGDAGGADDGVTEVLDRPLPEGIRRRVIGLVAEAFGGLTVAELPPQLRQYSRFTPSRRAKFAGNAMAAAVEGDPAFRQRISARLRESGSELVDALEAGSPPAAADPEDVAAMAFVLRPAGWVKLVTAAGEEAQRASAERAGEEAQRELRRLREELAAARAETKAEAERVRAELDAARKETEALQRKLRSALSDVRRGEAALRKAQAELESVRAEAQAEKAAASGETRRAKARLAEAEAALEASRRAAREGRSVEDVRLRLLLDTVLEGAQGLRRELALPPASVHPADTVDAVRPGMMTPRDIATRALSETDPALLDQLLALPQAHLVVDGYNVTKTGYPTMPLDKQRLRLLGGLAMLAAQSGAEVTCVFDGAELAAPVLLAPPRGVRVLFSKPGVTADELIRQLVRAEPPGRPVVVVSTDREVADGVAKAGARPVASALLLKRLART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9G6</accession>
    <name>A0A2G1X9G6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3093 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30670</name>
        <name evidence="3" type="ORF">CYQ11_23765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47873">
        <property type="protein sequence ID" value="PHQ47873"/>
        <property type="gene ID" value="BLA24_30670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15498">
        <property type="protein sequence ID" value="PPT15498"/>
        <property type="gene ID" value="CYQ11_23765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="15572" checksum="12951FFDC61E15AB" modified="2018-01-31" version="1">MQPYEERLTAPRSWWFIAVLAGIAMALILLPLGTLPMLGGLIGGGALAAVAVSSYGSVRIRVVGGALVAGDARIPLEALGAPEVLDAEEARAWRTHKADTRAFMLLRGYVPTAVRIEVTDPADPTPYVYLSTRHPELLAAALTAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9P3</accession>
    <name>A0A2G1X9P3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31365</name>
        <name evidence="4" type="ORF">CYQ11_24405</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47964">
        <property type="protein sequence ID" value="PHQ47964"/>
        <property type="gene ID" value="BLA24_31365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15588">
        <property type="protein sequence ID" value="PPT15588"/>
        <property type="gene ID" value="CYQ11_24405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="370" mass="38758" checksum="4D6B4B48A757C270" modified="2018-01-31" version="1">MRAPSAGRTAARWGCLRRLGLLPVLLLVGGALLDYNTPPHFSAEAFYTAAPMTAAALLSLRATILAGVGACAADLALLTHFGFIGDSGGQSELATVATVSAFAVVLNRLIYYSDVQLQSARRIALAVQRAVLPEPPASIGSLRIAVRYQSAVKEAQIGGDLYSVQDTPYGMRCVVGDVRGKGMEAVKAVDVALGAFREAAEEEPTLAGTAARLDRAVRREAEQRAGLERTEGFVTAVLAEIPPSGDELRLVNRGHPAPLLLHDGAVRAVEPSVPALPLALADLGADEDRTDTVPLPPGATLLLYTDGLTEARDRAGVFYDPVAGLSGRTFPDPDTLLDALLTEVAHHTGGRITDDMALLAVTRDGGGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9X4</accession>
    <name>A0A2G1X9X4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_31650</name>
        <name evidence="6" type="ORF">CYQ11_24705</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48011">
        <property type="protein sequence ID" value="PHQ48011"/>
        <property type="gene ID" value="BLA24_31650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15637">
        <property type="protein sequence ID" value="PPT15637"/>
        <property type="gene ID" value="CYQ11_24705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="328"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="482" mass="49540" checksum="1B134012C144E99F" modified="2018-01-31" version="1">MSRTSPPRPAAQAAPARARGPLARLRALPRTARTTPGGEPAASLAGVRAGFDVPSLRLVRLALHGAFYALLLVALAPALLGAGPAAVLPSACVLAVVYAAGVVRRPRRPGPWLAAVTALWLVLLAMDHGFSYVAFPLFFLYLHAMPVRWAHPAIAAATAAVVAAQAAGPGGLTPAKVIGPVAGAAVAVLTGYGYAALSKESRRRQLLIDDLVRTRDELAAAQREAGRLAERQRLAREIHDTLAQGLSSIVLLARAAESAGPQAVRERVREIGRTAADNLAEARRFVQALTPPALEDAPLPEALRRVTARTVPGAAFRLDGQPCPLPVETEVALLRLTQEALANVARHARAEHAAVTLAYLDGQVTLDVFDDGVGFAPGEGPADGRRTFGLHGMRERIAELGGTLTVESAPGEGTAIAATVPVRAAGPEPAVRLESAVPPEPAAGHGPDPDPGPRPGPGPGHTPHPGDASAPAGAPATGTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA34</accession>
    <name>A0A2G1XA34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32140</name>
        <name evidence="3" type="ORF">CYQ11_25200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48094">
        <property type="protein sequence ID" value="PHQ48094"/>
        <property type="gene ID" value="BLA24_32140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15720">
        <property type="protein sequence ID" value="PPT15720"/>
        <property type="gene ID" value="CYQ11_25200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="19240" checksum="6BBE4B95F0461250" modified="2018-01-31" version="1">MVVHRTVRDGEAKAVEAIDNSFTTDSVIEVTASDDGFRLRFVPVEPPLRKVYPDDEDDGAEGGETLVALDDGELCGAVTFAYEAWNRRLFIADVRVAPAHRGRGVGRGLVDRALARGRELGARTAWLEVTSVNAPAVRAYRRMGFAVCGLDMSLYAGTSSRGEVALFMSRALDEGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD0</accession>
    <name>A0A2G1XAD0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32765</name>
        <name evidence="6" type="ORF">CYQ11_25815</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48194">
        <property type="protein sequence ID" value="PHQ48194"/>
        <property type="gene ID" value="BLA24_32765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15820">
        <property type="protein sequence ID" value="PPT15820"/>
        <property type="gene ID" value="CYQ11_25815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="101" mass="10933" checksum="EF748375F291651B" modified="2018-01-31" version="1">MAVEPLSQKDVEERLQELPGWSVDGDRITRSYSFDGHFQAAAMVIHVAQIQEELGHHSDLTLGYNTLTLAVNTHSVGGKVTGLDVELARRVEAVAAGHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAU5</accession>
    <name>A0A2G1XAU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31610</name>
        <name evidence="4" type="ORF">CYQ11_24660</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48346">
        <property type="protein sequence ID" value="PHQ48346"/>
        <property type="gene ID" value="BLA24_31610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16772">
        <property type="protein sequence ID" value="PPT16772"/>
        <property type="gene ID" value="CYQ11_24660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758382" evidence="2">
        <location>
            <begin position="39"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="419" mass="46436" checksum="AF4CE96FE5223C2B" modified="2018-01-31" version="1">MRGKSMYGATALGSVCVVAALVVGLTGGGSDDRGSSAAASSGRPESGNPKDEAHGGAKEEEVWDGKVHVLGDGSTSYTGPQPNVKKPEKLKPGEKPPQFVVFSWDGALEGDDHLFSHFQEVAKENDAQMTFFLTGMYLLPKSKATLYKPPQHKPGDAAISFATDAHIRDTLKQVRSAWLAGNEIGTHFNGHFCGAKGGGDWSPAEWKSEIEQSYSFVQNWKTNTGYKDLPPLPFDYKKELVGGRAPCLEGQKNLLTAAKEFGWRYDASSPGDFQLWPSKVNDIWNFPLQLLPYPKSDKQVLSMDFNFLFNQSGDNTKGDPAKYEEWRKLTRDGYLNGFERVYNGSRAPLFIGNHFEDWNDGIYMKAVEDVMKSVCKRDGVRCVSFKQLADWMDVQDPKVLAKLRGLDPAQAPDWKSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAV2</accession>
    <name>A0A2G1XAV2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_33450</name>
        <name evidence="6" type="ORF">CYQ11_26500</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48309">
        <property type="protein sequence ID" value="PHQ48309"/>
        <property type="gene ID" value="BLA24_33450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15940">
        <property type="protein sequence ID" value="PPT15940"/>
        <property type="gene ID" value="CYQ11_26500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="239" mass="25978" checksum="F62A1FA6ED9E3EC1" modified="2018-01-31" version="1">MPPMARLLVVEDDPFVRSALIRQLTEAAHTVRSVGTALEALREVAQVGFDVVVLDLGLPDLDGAQALKMLRGITDVPVIVATARDDEAEIVRLLTDGADDYLVKPFSAAHLTARIAAVLRRAGGRTGHGGATGEPVPERVLRVGGLCVDPLRRQADLDGTPLDLTRREFDLLAYLAGRPGIVVPRKELLAEVWRQSYGDDQTIDVHLSWLRRKLGETAARPRYLHTLRGVGVKLEPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAW7</accession>
    <name>A0A2G1XAW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding transcriptional accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32965</name>
        <name evidence="4" type="ORF">CYQ11_26015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48384">
        <property type="protein sequence ID" value="PHQ48384"/>
        <property type="gene ID" value="BLA24_32965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16809">
        <property type="protein sequence ID" value="PPT16809"/>
        <property type="gene ID" value="CYQ11_26015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="652"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="786" mass="84524" checksum="FC044F363F2C76C5" modified="2018-01-31" version="1">MTTSIEGRIAEELGVRERQVRAAVDLLDGGSTVPFIARYRKEATEMLDDAQLRALEERLRYLRELEERRTAVLDSVRSQGKLDEALEARILAADSKARLEDIYLPFKPKRRTKAQIAREAGLEPLADGLLGDPDTEPLAAAAGFVSAEKGVADAAAALEGARAILTERFGEDADLIGELRERMWTRGRLVAKVRAGKEEAGAKFADYFDFAEPFTELPSHRVLAMLRGEKEETLDLTLEPEPAGETPAGPSSYEQAIARRFGIADRGRPADKWLGDTVRWAWRTRVLVHLGIDLRLRLRQAAEDEAVRVFAANLRDLLLAAPAGTRATMGLDPGFRTGVKVAVVDATGKVAATETVYPHVPQNKWDASLATLARLAREHGVELIAVGNGTASRETDKLAGDLISRHPELKLTKVMVSEAGASVYSASAFASQELPDLDVSLRGAVSIARRLQDPLAELVKIDPKSIGVGQYQHDLSEVKLSRSLDAVVEDCVNGVGVDVNTASAPLLSRVSGIGAGLAENIVAHRDANGPFRSRRALKDVARLGPKAYEQCAGFLRIRGGDDPLDASSVHPEAYPVVRAMAKRTGGDVASLVGDTATLRSIRADDFVSDSFGLPTVTDILRELEKPGRDPRPAFKTAVFKEGVEKIGDLAPGMLLEGVVTNVAAFGAFVDVGVHQDGLVHVSAMSKTFVKDPRDVVKPGDIVRVKVMDVDIPRKRISLTLRLDDESPAGGRAGATAAPRERAERGAPRRGGTPRPRRAEGREAAAADGAMADALRRAGLLGGPKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAZ3</accession>
    <name>A0A2G1XAZ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000166">
        <property type="protein sequence ID" value="PHQ48404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48404">
        <property type="protein sequence ID" value="PHQ48404"/>
        <property type="gene ID" value="BLA24_30075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="115" mass="12251" checksum="FD18FCE8B94FA343" modified="2018-01-31" version="1" fragment="single">MEARSIVDEVTAGPRMSDPVELVPEMAEVSAALFKAVGNHTVARTTISLVHLRAGQIVGNTYLTVLHTGFLRKAGESEERITAVSSWRDAPCFTPAERAALALVEAVLLPSAHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB78</accession>
    <name>A0A2G1XB78_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_29305</name>
        <name evidence="10" type="ORF">CYQ11_06170</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48465">
        <property type="protein sequence ID" value="PHQ48465"/>
        <property type="gene ID" value="BLA24_29305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12538">
        <property type="protein sequence ID" value="PPT12538"/>
        <property type="gene ID" value="CYQ11_06170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="551" mass="55649" checksum="24A9B2A17F47D1D3" modified="2018-01-31" version="1">MDGSSGTGRALAGRYRLLDRLGQGGMGVVWRARDEALGREVAVKEVRAPAGLPEPQVRQLYARLEREGRAAARISHRNVVTVHDVVTDGGRPWIVMELVRGMSLADVLEADGPMDPRRAAHVGVEVLAALRGAHAVGVLHRDVKPGNVLIAADGRVVLSDFGIAMIEGTSALTATGQLVGSPEYLAPERALGRPPGPESDLWSLGVLLYAAVEGCSPFRQDTPLSTLRAVVDSRLPPPRRAGALGPVLDGLLRKDPAERLGAAEAERLLRTVAAGGAEHPAAPGAYAPTVAAHPAAPAAAGTPAPSGPAGAAGDGAPPRAPDPRTGTPPPGAGPGGRARVALVAGVLVAALAAAGLVWGLTRDDGGSDGGGRAEGSATGGADKNTGVEPPGGAASASARASGAYTVEVALAALRDRYAGPCPPPAAAAPSFRAAITVAGGPADLSYRWVTGSGRVSDGGWQRVRFGDGTSTRQAEHVETAHRAGDAEQDWIALEVKDDRRSQSSRHVPFTVSCRADPTGGASSPGSSPGPSGRSGTPGPSAGRPTGPGAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBD1</accession>
    <name>A0A2G1XBD1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_29640</name>
        <name evidence="8" type="ORF">CYQ11_05835</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48520">
        <property type="protein sequence ID" value="PHQ48520"/>
        <property type="gene ID" value="BLA24_29640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12481">
        <property type="protein sequence ID" value="PPT12481"/>
        <property type="gene ID" value="CYQ11_05835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="32195" checksum="06DAA257DA5D6605" modified="2018-01-31" version="1">MSEPTGAARRRGPFQVGDQVQLTDPKGRHYTFTLEAGKNFHTHKGSFPHDELIGAPEGSVVRTTGNVAYLALRPLLPDYVLSMPRGAAVVYPKDAGQILAFADIFAGARVVEAGVGSGSLSAFLLRAIGDQGMLHSYERRADFAEIAQANVERYFGGPHPAWQLTVGDLQDNLSDTDVDRVILDMLAPWECLEAVSKALVPGGILCCYVATTTQLARTVESIREIGCFAEPQPWESMIRNWHVEGLAVRPDHRMIGHTGFLVTARRLADGVEPPMRRRRPAKGAYGDDYEGPNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBI5</accession>
    <name>A0A2G1XBI5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF402 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29210</name>
        <name evidence="3" type="ORF">CYQ11_06265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48586">
        <property type="protein sequence ID" value="PHQ48586"/>
        <property type="gene ID" value="BLA24_29210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16377">
        <property type="protein sequence ID" value="PPT16377"/>
        <property type="gene ID" value="CYQ11_06265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="163" mass="18081" checksum="44A1C6A3E8B9D364" modified="2018-01-31" version="1">MRLAAGTTVTVALEKAGRVKVRYPAAVVSDDGAHVVVRAPWAGEKDRDFGFVRFEGGDVFTEHYWRDRWYSVKEVRDAEGALKGWYCDVARPARVGPEGIAVEDLDLDLWLSGDRSAVLRLDEDEFAASGLAERDPEAARAAWRALDELEDLARGGDFEDLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC26</accession>
    <name>A0A2G1XC26_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HGTP_anticodon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000157">
        <property type="protein sequence ID" value="PHQ48751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48751">
        <property type="protein sequence ID" value="PHQ48751"/>
        <property type="gene ID" value="BLA24_28110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HGTP_anticodon" evidence="1">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="158" mass="16632" checksum="07AAA09F1F8987DC" modified="2018-01-31" version="1">MTAWYGHQAGRADPRAQGAVLRAPGLRAQPLSTHRVEARVGEAEEFVRRCVERGLRAEARGPEHGTLGARVRSARLVPYQAVIGPREATDGLVALRLRDGRRLDPLPAGEALGRIKGVVVSRRGELWGEEGGVNGGAGGAGAPGGCPYGFRQPVGAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC64</accession>
    <name>A0A2G1XC64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48816">
        <property type="protein sequence ID" value="PHQ48816"/>
        <property type="gene ID" value="BLA24_27495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="491" mass="51440" checksum="459C600865251FC6" modified="2018-01-31" version="1">MSVGIDFAEDGVVPAGVELNAGRAGHADAAGRGYLVTAPHQSGPARQGAAPDTDDHDLLAALLDGMDAALCAFDADGTVTHWNREAERILGWSAAEAVGRHGLTGWAVREADAQEVTARLLGAMTAPGRQVDEFALLTKDGGRVLVRVQSSAVPGADGRPAGVYCAFSEVHTQIDLERSVALSEALFGEASAWGVVLVDADLRPALANAHAARALRTSRTALLGRPLGDLLEQGVEELEGAIQHVLAAGTPPEPSELWVTVRDPRGGTLPPERRCWRSGFLRLASPLAEEPVPLGVAWLFLDVTKTRLAEQESARLRFRGSQLHRAGRAVAECEDPMEAAVLYMDFALAGFADHALIDLLPEPEAAPEGPVRLVRAATTPAGVPGPGALPVGGGLPVAYREGHPALQAVERCGSVRAATDRSVSWAADHKWPDGTRHGLATALRSRGRTMGAVTFLRGASRRPFDRADAAYAEDIASRVAAAIDLAAAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC67</accession>
    <name>A0A2G1XC67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27455</name>
        <name evidence="2" type="ORF">CYQ11_18190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48808">
        <property type="protein sequence ID" value="PHQ48808"/>
        <property type="gene ID" value="BLA24_27455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14544">
        <property type="protein sequence ID" value="PPT14544"/>
        <property type="gene ID" value="CYQ11_18190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="462" mass="49913" checksum="F6D69B028B821623" modified="2018-01-31" version="1">MAARPLVARQPNERLQALIQEAGCSNAGLARRVNMCGAEHGLDLRYDKTSVARWLRGQQPRGRAPAVIAEALGRKLGRSVTIDEIGMANGKNLASGVGLQFSPTVLGAIEQVCELWRSDVGRRDFLSGTSVASSALVEPSRDWLITAADPQVARNAGARVGPSDVEAVRATTEALVELDHRYGSGHVRPVVVHYLNSVVSGLLAGSYREAVGRDLFAAVARLTELAGYMAVDTGQPGLAQRYYIQALRLAQAAGDRGYGGYVLAASMSHLAASLGNPREIAQLAKAAQEGARGHVTPRAEAMFYAAEARGHALLGDARSCQVVASRAVTRLEAADNGTDSGDDPPWIRHFDRAYLSDELAHCHRDLGQAEPARRHAEDALAAHPRGRVRRRAIDLLLLATAHVQQREVEEACVTGTRALELLGTLRSNRGSEYLDDFQQRLEPYRDEPVVREFGARMEMQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCP4</accession>
    <name>A0A2G1XCP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23065</name>
        <name evidence="3" type="ORF">CYQ11_23010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48988">
        <property type="protein sequence ID" value="PHQ48988"/>
        <property type="gene ID" value="BLA24_23065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15367">
        <property type="protein sequence ID" value="PPT15367"/>
        <property type="gene ID" value="CYQ11_23010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="19543" checksum="C757830EC0B1A98E" modified="2018-01-31" version="1">MDDIAVGPLDLARRVDEALAVQAVAFGLTAEEVAVRRHIVLRHLACPGARALGATTPDGRLVGFVYGMPNDRTHWWSTVVEPYLRTNGYDDWLDGSFVITELHVHPAFQNRRIGRTLITSITATAQERRSILSAIDKESPARALYRKLGYRDLARHVVFPSAPSPYAVMGAELPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD05</accession>
    <name>A0A2G1XD05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_23755</name>
        <name evidence="5" type="ORF">CYQ11_22320</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49100">
        <property type="protein sequence ID" value="PHQ49100"/>
        <property type="gene ID" value="BLA24_23755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15254">
        <property type="protein sequence ID" value="PPT15254"/>
        <property type="gene ID" value="CYQ11_22320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304715" evidence="2">
        <location>
            <begin position="35"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="64"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="39156" checksum="CE682137BA8F760B" modified="2018-01-31" version="1">MRGTPNATVRAALAAASALLLLAGCSDDGSPSTGAGTAGTGGPSASAAPAKGSAEVVRTIATRLNSPWGVAVLPGGDLLVGSRDTGRIVRVGAGDGRQSELGTVPGVAAAGEGGLLGLALSPGYGADHWLYAYFTTESDNRVVRMLVDDARPEGQRLGAPDTILRGIPKGPVHNGGRIAFGPDGMLYAGTGESGRRGLAQDLDSLGGKILRMTPDGRPAPGNPRADSVVYSHGHRNVQGLAWDADGRLWASEFGQDTWDELNLVRPGGDYGWPLAEGRAGKPGLVDPVEQWKPAAASPSGLAYAGGALWMAGLRGRTLWRIPLRGERPAASPQAFFEGEYGRLRTVVATSGDTLVLTTSNTDGRGKPDAQDDRLLLLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD18</accession>
    <name>A0A2G1XD18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23820</name>
        <name evidence="4" type="ORF">CYQ11_22250</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49110">
        <property type="protein sequence ID" value="PHQ49110"/>
        <property type="gene ID" value="BLA24_23820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15242">
        <property type="protein sequence ID" value="PPT15242"/>
        <property type="gene ID" value="CYQ11_22250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758406" evidence="2">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="204" mass="19823" checksum="251A462F912F7739" modified="2018-01-31" version="1">MKLRHVRAAAIFGICVVALTGARGHHGGSCGGSSHSSSHSSSGGSTSGGSTTGGDSSSGTFGGTTSGGSTTGGTTGSGTSSGTTSGTTGDSSSGSSSVLGSSGGGSGSAMSDIKILSCSYSDRLGITAKVQATNSSATRYDYRLTVKFYGPDRALLATRNPSIPSVGPGKTDTLDVSTPYVPKPGTSGTVRCEIPTVTRTAASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD55</accession>
    <name>A0A2G1XD55_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24210</name>
        <name evidence="5" type="ORF">CYQ11_21865</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49173">
        <property type="protein sequence ID" value="PHQ49173"/>
        <property type="gene ID" value="BLA24_24210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15177">
        <property type="protein sequence ID" value="PPT15177"/>
        <property type="gene ID" value="CYQ11_21865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="224" mass="23596" checksum="17592D381E803C28" modified="2018-01-31" version="1">MTSAPSPARRPGASRTGRPRSADADRAILTATRAALVELGWGKLTLGDVAARAGVAKTTLYRRWAGKNELVVDAVAALFDEHLELPDRGSLHADVEGVVLQFAALLERPETKTALMAVVAESTRDDALRDRIRSAIVDRQKSLVLLGRERAQLRGELPREEDGAAAARTADLIFDVIAGAVVHRTLVSAEPVDAEWARGFTALLVGGLTAVAVPGAAGGRAPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF4</accession>
    <name>A0A2G1XDF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent malic enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">NADP-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_24690</name>
        <name evidence="8" type="ORF">CYQ11_21380</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49262">
        <property type="protein sequence ID" value="PHQ49262"/>
        <property type="gene ID" value="BLA24_24690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15086">
        <property type="protein sequence ID" value="PPT15086"/>
        <property type="gene ID" value="CYQ11_21380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="177"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="404" mass="41969" checksum="351E4177F2ED7272" modified="2018-01-31" version="1">MAAEIVNPRSDNGPDEGSREELFDPAFALHRGGKMAVQATVPVRDRDDLSLAYTPGVAKVCSAIAEQPELVHDYTWKSQVVAVVTDGSAVLGLGDIGPEASLPVMEGKAILFKQFGGVDAVPIALDCREVDEIVDTVARLAPSFGGINLEDISAPRCFEVERRLQERVDIPVFHDDQHGTAVVTLAALRNAAQLTGRTLGELRAVISGAGAAGVAIARILVEAGIGDVAVCDRKGIVSGDREDLTDVKRELAGFTNKAGLTGPLETALDGADVFIGVSGGTVPESAVAKMAKNALIFAMANPTPEIHPDVAHKYAAVVATGRSDYPNQINNVLAFPGIFAGALQVRASRITEGMKLAAAEALAAVVADELSADCVIPSPFDERVAPAVTAAVAAAARADGVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDM6</accession>
    <name>A0A2G1XDM6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">whiB</name>
        <name evidence="15" type="ORF">BLA24_25100</name>
        <name evidence="16" type="ORF">CYQ11_20970</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49332">
        <property type="protein sequence ID" value="PHQ49332"/>
        <property type="gene ID" value="BLA24_25100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15020">
        <property type="protein sequence ID" value="PPT15020"/>
        <property type="gene ID" value="CYQ11_20970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="14">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ49332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT15020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="13047" checksum="059E461579A34C29" modified="2018-01-31" version="1">MQLKTHTPSVATDLIPPPVPTEDTLTPLTSLTDLDDAIENLGGSVPCRSYDPEVFFAESPADVEYAKSLCQTCPLREACLAGAMDRREPWGVWGGELFVQGVVVARKRPRGRPRKNPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDP6</accession>
    <name>A0A2G1XDP6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49363">
        <property type="protein sequence ID" value="PHQ49363"/>
        <property type="gene ID" value="BLA24_25280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="50" mass="5516" checksum="CC90FAB812C79BBF" modified="2018-01-31" version="1">MRFEIMRLDDIDGAAVDSTVVDAASVNRIVQQAALTGQRIYIRPADPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDQ8</accession>
    <name>A0A2G1XDQ8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_25335</name>
        <name evidence="8" type="ORF">CYQ11_20740</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49374">
        <property type="protein sequence ID" value="PHQ49374"/>
        <property type="gene ID" value="BLA24_25335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14978">
        <property type="protein sequence ID" value="PPT14978"/>
        <property type="gene ID" value="CYQ11_20740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="386" mass="39872" checksum="39256A61E0C5419C" modified="2018-01-31" version="1">MATDTYGTAAPGEDAIRVALATVNDPEIQRPITDLGMVKSVEIAADGSVAVAVYLTVSGCPMRETIISRVTEAVSRVEGVTGVSVELDVMSDEQRRELAASLRGGQAEREVPFAKPGSLTRVYAVASGKGGVGKSSVTVNLAAAMAADGLKVGVVDADIYGHSVPRMLGADGKPTQVENMIMPPSANGVKVISIGMFTPGNAPVVWRGPMLHRALQQFLADVYWGDLDVLLLDLPPGTGDIAISVAQLVPNAEILVVTTPQQAAAEVAERAGSIAVQTHQKIVGVVENMSGLPCPHCDEMVDVFGTGGGQLVADGLTRTTGTNVPVLGSIPIDVRLREGGDEGKPVVLTDPESPAGSALRAIAGKLGGRQRGLSGMSLGITPRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDV3</accession>
    <name>A0A2G1XDV3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25320</name>
        <name evidence="3" type="ORF">CYQ11_20755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49371">
        <property type="protein sequence ID" value="PHQ49371"/>
        <property type="gene ID" value="BLA24_25320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14981">
        <property type="protein sequence ID" value="PPT14981"/>
        <property type="gene ID" value="CYQ11_20755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304862" evidence="1">
        <location>
            <begin position="32"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="25322" checksum="A4DC46130CF1345D" modified="2018-01-31" version="1">MRTRNAALVGALCVGLSAVLTACGGTEDPDAGTNGVGKLEPAAIQDKARTAARGAQAVHLSGNIVSEGRTYRIDMRLKNNGGAGRVSSSGAAAFELLRVGDDLYLKAPAGFWSRGSSPSPTAKADPAAAAGKLDDKYVKVPADDPSYQQLKGFTDKNVLLDGLIGLRGKLARGAHGTVGGVRTIHVTGSGGAGGTLDVSLTGTPYPVRVQRAGGAGQLELGDWGKDFALAVPDKGQTVDYGKQLQIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE13</accession>
    <name>A0A2G1XE13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25895</name>
        <name evidence="2" type="ORF">CYQ11_20175</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49473">
        <property type="protein sequence ID" value="PHQ49473"/>
        <property type="gene ID" value="BLA24_25895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14877">
        <property type="protein sequence ID" value="PPT14877"/>
        <property type="gene ID" value="CYQ11_20175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039452">
        <property type="entry name" value="DUF5403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17395">
        <property type="entry name" value="DUF5403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="14043" checksum="4E6B55E90A0D1D06" modified="2018-01-31" version="1">MAKVYQSVNGRKIEKYVAVNEGVQAELTARAFEIAVRAEEILVQHRADGHAEIDVEAGDNNRYVILSDDRGQKAALSIEYGRAESVIVRKDRDGGKYLDVLPAMDGLYILATASNLPKKRKGKVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE21</accession>
    <name>A0A2G1XE21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25950</name>
        <name evidence="2" type="ORF">CYQ11_20120</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49483">
        <property type="protein sequence ID" value="PHQ49483"/>
        <property type="gene ID" value="BLA24_25950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14867">
        <property type="protein sequence ID" value="PPT14867"/>
        <property type="gene ID" value="CYQ11_20120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="75" mass="7751" checksum="97D15F16525A0336" modified="2018-01-31" version="1">MSKMLMPGSKPISLVSLLPVRYRTRVGAVLSAVGVAVSIAAIVYADSPEVAVIVQILTALGVVAPSEDDSPEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE71</accession>
    <name>A0A2G1XE71_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_26200</name>
        <name evidence="6" type="ORF">CYQ11_19440</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49526">
        <property type="protein sequence ID" value="PHQ49526"/>
        <property type="gene ID" value="BLA24_26200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14754">
        <property type="protein sequence ID" value="PPT14754"/>
        <property type="gene ID" value="CYQ11_19440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="230" mass="24410" checksum="60E39DE1785ABC8B" modified="2018-01-31" version="1">MIPAGSLLTATGLRKSYGPNTALDGANFSLHAGEVVAVMGPSGSGKSTLLHCLAGIVPPDEGTVTYEGRDLATLSDAERSALRRTRFGFVFQFGQLVPELTCLENTALPLRLTGVRRKEAEARALVCLERLEVADVRHHRPGQISGGQGQRVAVARALVTEPRVIFADEPTGALDSLNGERVMQLLTETARAGNTAVVLVTHEARVAAYSDREVIVRDGLVRDMAGTGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEF7</accession>
    <name>A0A2G1XEF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26725</name>
        <name evidence="3" type="ORF">CYQ11_18910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49617">
        <property type="protein sequence ID" value="PHQ49617"/>
        <property type="gene ID" value="BLA24_26725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14663">
        <property type="protein sequence ID" value="PPT14663"/>
        <property type="gene ID" value="CYQ11_18910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="15742" checksum="19909DC05AC81AFA" modified="2018-01-31" version="1">MNSHGTLTDDELRRAWASANAADAADATENAPGDGPLGPADRDRHPWLAPGWATGLALLLVPVAVLFGGLSPMATDSCGPDHCSRALNQALAGIVWCLYATFTATPLMLLVSWALPPRMRYAAARRLAAWCALLPPLAVILMVFDLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEH1</accession>
    <name>A0A2G1XEH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26790</name>
        <name evidence="2" type="ORF">CYQ11_18845</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49626">
        <property type="protein sequence ID" value="PHQ49626"/>
        <property type="gene ID" value="BLA24_26790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14653">
        <property type="protein sequence ID" value="PPT14653"/>
        <property type="gene ID" value="CYQ11_18845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="429" mass="46508" checksum="80F894DE92FA0405" modified="2018-01-31" version="1">MLADSDTRWKWGALTAHRIAPGGRLDGFLLRGRATPTVRQLAEVGVRPDALREVTGTEFVHAVDRDRYDVVVLACVGGAVQAMLHGLAATWRGRPRRPVVVTGYVGVVYEKLADGLLLRHGADLVLANSRHDAERFRAVYEGAGAPADGVTECALPFLGGARYAGRPPGRPYTLAFAAQPSVPDRKEDRMYLLERAARHARRHPDREVLIKLRSKPGEHTTHIEELPYQKLAVRLPGGLPPNCRPVYGHMGEVLDRTDLLVTVSSTAALEALHRGVPTAVLTDLGIREPLGNHHFLGSGCLASWDQLDAGHLPVPDPAWTARQGVAPDGTYEHAFDTARERVAELAARPVLPPLAPYYTARTAPGYLPGVLARHGLDPTGRPLPGRAAPGRPESALARLTRGALRDAARSAYRHGVQRVAPVIRRLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEJ1</accession>
    <name>A0A2G1XEJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26910</name>
        <name evidence="2" type="ORF">CYQ11_18725</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49648">
        <property type="protein sequence ID" value="PHQ49648"/>
        <property type="gene ID" value="BLA24_26910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14630">
        <property type="protein sequence ID" value="PPT14630"/>
        <property type="gene ID" value="CYQ11_18725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="70" mass="7796" checksum="B7299C77091D87F7" modified="2018-01-31" version="1">MSSPRRTCPVCAREIAVVGGRYARHDPPGRRVSYDLVSCPGSRRSAPLLATEPRLFDPEEPPMEGQQQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEM3</accession>
    <name>A0A2G1XEM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_23375</name>
        <name evidence="9" type="ORF">CYQ11_22700</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49694">
        <property type="protein sequence ID" value="PHQ49694"/>
        <property type="gene ID" value="BLA24_23375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16730">
        <property type="protein sequence ID" value="PPT16730"/>
        <property type="gene ID" value="CYQ11_22700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="494" mass="52032" checksum="722D39E9485B0C01" modified="2018-01-31" version="1">MDNAAEGANVSSPEGAAGAIETRGIEPVPDHERHGRVRELFPTWVAANISVLLLTMGAALIVFNALNFWQVLIVAACAALVSFGLVGVLSVSGKWGGAPGAMLSRATFGVRGNLFPGAILWVARFGWETINAVTGAYAVLTVLDLVLGVKSNTALIVVTLFVFVASTFLVSGMGRKALNVCNTWSTYLFGVFSVLVLGYLIANIKWDEVFSKPAGTTAMMIAGIGTIAAGGISWVPTGPDFARYLPHAASGKKIVGVTVSGAGLVMVPMVLMGGVMAVATPELADAPDPVSFLGDILPTWLAVPYLITAIVGMLLINSLSMYSAGFTAQTMGVKLPRAMAVSINAAISLIGGLLLMLVAKSFLSSFITFLILLAVSFSAWIGVYAVDMARRRSRAVRYDAEALMDTGRTSRYWYVGGYCWQAMTAWGVALVAGLCFTKCDWFSGPLASTFVGKYGLGWAATIVISAVMMAVLPVPRENGAGRVERATEREKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEN3</accession>
    <name>A0A2G1XEN3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate--2-oxoglutarate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabT</name>
        <name evidence="5" type="ORF">BLA24_23110</name>
        <name evidence="6" type="ORF">CYQ11_22965</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49683">
        <property type="protein sequence ID" value="PHQ49683"/>
        <property type="gene ID" value="BLA24_23110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16741">
        <property type="protein sequence ID" value="PPT16741"/>
        <property type="gene ID" value="CYQ11_22965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003867">
        <property type="term" value="F:4-aminobutyrate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="450" mass="47004" checksum="9ACB4B7BB08D309D" modified="2018-01-31" version="1">MTALSGGAALPQERRIVTAIPGPKSLELQARRIAAVAGGVGSVLPVFTTRAGGGVIEDVDGNSLIDFGSGIAVTSVGASAEAVVRRASAQLADFTHTCFMVTPYEGYVEVCEQLAELTPGDHAKKSALFNSGAEAVENAVKIARAYTKRQAVVVFDHGYHGRTNLTMALTAKNMPYKHGFGPFAPEVYRVPVAYGYRWPTGPENCGPEAAAQAIDQITKQIGAENVAAIIIEPVLGEGGFIEPAKGFLPSIVKFANDNGIVFVADEIQSGFCRTGQWFACEDEGIVPDLITTAKGIAGGLPLAAVTGRAEIMDAAHAGGLGGTYGGNPVACAGALGAIETMRELDLNAKAKRIEEVMKGRLSAMQEKFAVIGDIRGRGAMIAIELVKDPATKEPNPEAAGALAKACHAEGLLVLTCGTYGNVLRFLPPLVIGEDLLNEGLDIIEEAFTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XET0</accession>
    <name>A0A2G1XET0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_25435</name>
        <name evidence="6" type="ORF">CYQ11_20640</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49733">
        <property type="protein sequence ID" value="PHQ49733"/>
        <property type="gene ID" value="BLA24_25435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16693">
        <property type="protein sequence ID" value="PPT16693"/>
        <property type="gene ID" value="CYQ11_20640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="190" mass="20099" checksum="A63D6BAB18020ADD" modified="2018-01-31" version="1">MVREALAALLGLEEDIEVVVQVARGDEVLDAARRTPVDVALLDIEMPGMTGLDAALLLRGELPALKVVILTTFGRPGYLRRAMESGADAFLVKDAPAAQLADAVRRVLRGERVIDPTLAAAALAEGANPLTDRERAVLSASADGSTNAELAAALHLSQGTVRNYLSVAIQKTGARNRAEAVRIARDKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEY2</accession>
    <name>A0A2G1XEY2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26990</name>
        <name evidence="3" type="ORF">CYQ11_18645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49765">
        <property type="protein sequence ID" value="PHQ49765"/>
        <property type="gene ID" value="BLA24_26990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14616">
        <property type="protein sequence ID" value="PPT14616"/>
        <property type="gene ID" value="CYQ11_18645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="10243" checksum="2574B9A1BBF790B9" modified="2018-01-31" version="1">MVKSSGEAAPRTPATLSRPVSWFLLAFGVWSWFIWITFVKNLWKDGSGLAFDDAGEPTGYFWVHLLLAVTSFLLGTAVGLIGLRGVRALRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEY6</accession>
    <name>A0A2G1XEY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF2029 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_19285</name>
        <name evidence="9" type="ORF">CYQ11_11515</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49796">
        <property type="protein sequence ID" value="PHQ49796"/>
        <property type="gene ID" value="BLA24_19285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13428">
        <property type="protein sequence ID" value="PPT13428"/>
        <property type="gene ID" value="CYQ11_11515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="416" mass="43782" checksum="60DD6D45EB66582C" modified="2018-01-31" version="1">MSTSPASGPRPGFTPWLYGRAPRPVLCAAVLVYALSAIRSYEKARTGIDNEVVVRAARTLLEGGSPYADKRFLYLPGAVFAALPQTLCSERVLFYGVPVVTGLLVAVGAVVALRIFGVRADSRLAAGVAVGLALFLPFHSLTTLGNWTAASVVAFPAALLAARHGRWGAAGAVTGAAIALKPMLVPLLLLFVLARQWRGLAWAVGIPVAASLAAASAMPRPGLFFTRTLPFLLHGQDAYARPYDAAWPAFLPRVGVPQPLAFTLATAAATAVLYCARLRWRGGGDEGLRLVECASLLMLAAFVVFRPSFMNYALVVVPSLTASAVARGAAARSVWFWMPLVPQLGGVPWPGLESAQRHAFKDVVMFGGLAAALALAAWRRRVPHGTNGLVTAATAVTVSGGAYSLCSEFEPRPSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEZ5</accession>
    <name>A0A2G1XEZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_19315</name>
        <name evidence="7" type="ORF">CYQ11_11485</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49802">
        <property type="protein sequence ID" value="PHQ49802"/>
        <property type="gene ID" value="BLA24_19315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13422">
        <property type="protein sequence ID" value="PPT13422"/>
        <property type="gene ID" value="CYQ11_11485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="452" mass="46998" checksum="0FFB24399680E664" modified="2018-01-31" version="1">MSTATPGAAAPAGPAVPKATGRGGALGTRPWVAACFLLPALALLGALVVYPIGYSVYRSLFDASGDGFVGFGNYQEVFTDDRIRTALKNNVVWVIVAPAVATALGLIFAVLTERVRWGTAFKLVVFMPMAISMLAAGIIFRLVYEQDPDRGVANAVWVGVHDTFAAPAPYPGAHPRPNGGLAASGGGAFTTTSPVRAGAAVALPLVAVKPEDAGGAKEAIPARDVGGKVTGTVWMDFTRGGGGTAGKIDAEEKALAGVRVEAVKDGRTVASATSASDGTFTLPPAADGARLRLPASNFASAYNGVDWLGPTLVTPSIIGAYIWMWAGFAMVLIAAGLASVPRELLEAARVDGANEWQVFRRVTVPLLAPVLAVVVVTLMINVLKIFDLVYIIAPGSSLHDANVLALQLYQSSFGTDVNQGVGSAIAVFLLLLVTPVVVVNIRRIRKEREGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF95</accession>
    <name>A0A2G1XF95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR01457 family HAD-type hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19890</name>
        <name evidence="4" type="ORF">CYQ11_10900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49897">
        <property type="protein sequence ID" value="PHQ49897"/>
        <property type="gene ID" value="BLA24_19890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13327">
        <property type="protein sequence ID" value="PPT13327"/>
        <property type="gene ID" value="CYQ11_10900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="27890" checksum="B9E5A9CBF7C0FE20" modified="2018-01-31" version="1">MAERKPIESWLTDMDGVLMHEGIPVPGADSFIKRLRESGKPFLVLTNNSMYTPRDLHARLARIGLDVPVRNIWTSALATAQFLADQRPNGTAYAIGEAGLTTALHDIGYVLTDADPDYVVLGETRTYSFEALTKAIRLINNGARFIATNPDETGPSAEGALPATGSVAALITKATGRDPYFVGKPNPLMMRAGLDAIGAHSETSAMIGDRMDTDVLAGLEAGMETFLVLTGLTRPEEIDLHPFRPSRVVDSIADLVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFG5</accession>
    <name>A0A2G1XFG5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FtsK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49984">
        <property type="protein sequence ID" value="PHQ49984"/>
        <property type="gene ID" value="BLA24_20430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="306"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="331"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="680" mass="72874" checksum="34F7A7C7690903E1" modified="2018-01-31" version="1">MDDSGPVLVDRLAPVSSGPGLLDRVRDSKRLDVLPGWLKSRAEFTDAAAWLAGHVGHTVAFHAVRSPLYAAKLIGRSPAGAARIIGGRMRWVADIESEPLRQAAASAENAEEYLKLTRQRDRRVRWRGAVAVATLPVLLALTLYLVYGASLWLQLAVLAVTVCWCGILGAPADKPLSSRAVIKPEVQKLTSDMVVKAMASIGIGQIASAVAKGLDGIKFVAPITREGPGWRADIDLPLGVTVGDVADRRARLASGLRRPLGCVWPEADPAEHEGRLILWVGDRDLSKTGIVKWQLANARRHDVFKRVPFGLDPRGRSQSVPLIQHNVLIGSQPGQGKTASVRVLACGAALDPSVELWLHENKGTGDLDALACVSHRFVSGIDDESVKYAADSLKLLREEVMRRAAAIKKLPRDLCPDKRITREIADKRSLKLWPLLAVFDECQNVFAHSAYGKQAGEDAEFVIKLGRALGVILVLATQRPDKDSLPTGISGNVSIRFCLRVAGQVENDMILGTSAYKNGVRATAFRPEIDAGNGYLAGAAPLPTVVRTAYLDDPATNAIAQRALALRKGAGTLSGFALGEESETTAGPSYDLLADIAAVVPASEERVWNERIAARLAELRPDVYAGWKGENVTSALKPHGIKTTGVAGTTDDGARTTRRGIVRADLTKAIAERDGNPGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFI3</accession>
    <name>A0A2G1XFI3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_20530</name>
        <name evidence="7" type="ORF">CYQ11_10250</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50000">
        <property type="protein sequence ID" value="PHQ50000"/>
        <property type="gene ID" value="BLA24_20530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13222">
        <property type="protein sequence ID" value="PPT13222"/>
        <property type="gene ID" value="CYQ11_10250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="114"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="382" mass="39690" checksum="71C88133D0880BD5" modified="2018-01-31" version="1">MSQLPPQLTACPVCHEPLEPADNFCGGCGADLSAAPPPGDTGWRRTDTPVVRGADDHRAAPPGGAVPAQPAHGAGTGRACPACRSGMIDNDGYCEHCGQAQPHERDHMEHESAGVAAVSDRGLRHHRNEDAFTVSTTDLPDGPPVVVAVVSDGVSSAARPDEASAAACAAAHDELTTALAGGTPPREATHHAVVRAAEAVSSLAATAAEAREHDRYRQENAPACTIVSAVVTGDLLTVGWVGDSRAYWVPDDRSTQPARLTEDDSWAAQMVAAGLMSEAEAYADERAHAITGWLGADAYEVEPHTASYHPDRPGVVIVCTDGLWNYAESAEHMAAIVPPDARSRPLECARRLLAHALDGGGHDNVTVAVLPFPARPEGAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFJ3</accession>
    <name>A0A2G1XFJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_20600</name>
        <name evidence="6" type="ORF">CYQ11_10180</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50014">
        <property type="protein sequence ID" value="PHQ50014"/>
        <property type="gene ID" value="BLA24_20600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13208">
        <property type="protein sequence ID" value="PPT13208"/>
        <property type="gene ID" value="CYQ11_10180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="865"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1028" mass="108215" checksum="E9CF10B6BCBFFD89" modified="2018-01-31" version="1">MRFLGSDPCHGRAAGPGRPARPGPRRAGVTVLTAALLGGLLGNATGALAEPRPGDAAAAAGSPGTPDREAAGALPPIWPRPQSARAQGPYVRVGEDVTLMADQGTDPRTIEALRAILHALGARTVVDAQPGGTPPPSGLIVQAGGLGAEDALRALGAGPLDDLPTGGYRLATGQVDGRPTVALAGVGEDGLFHAAQTLRQLAVDHDGGKAFAGAVIRDWPGTAVRGLTEGFYGQPWSLSERLAQLDFMGRTKQNRYLYAPGDDPYRQARWRDPYPAEQRAAFRELAEGARRNHVTLGWAVSPGQAMCFSSAEDVRALKRKVDAMWALGVRAFQLQFQDVSYSEWHCGADADAFGSGPKAAAKAQAKVAGALAEHVAGKGPEAAPLSLLPTEYYQEGRTAFRRALADALDRRVEVAWTGVGVVPKTITGGELAEARAAFGHPLVTMDNYPVNDFAQDRLFLGPYTGREPAVAAGSAALLANASAQPTASRIPLFTTADYAWNPRGYRPEESWRAAVADLAGDDAASREALGALAGNDASSVLGGEESAYLKPLLDEFWAALSAADAGRLSTAADRLRAAFRTMAGAQSRLGPALGGEVRPWLEQLTRHGEAGVRAVDMLTAQARGDGAAAWQAQLDVQRLRERIRAGRATVGKGVLSPFLDRALASANGWTGVDRPVRTAGEATDGAPATAVVPRPGAPLDVRLPEPHPLTVVTLLTDPAPGVHGTAWAHDAAGGWQRLGPLSDSGWTQVPGKGVRADALRVVWEGNTAAAPPAVHEVAPWYADTPTADFELTPGTTDAEAGGRPAVLQARMINRRPEPVTEKLVVKAPQGVTVKAPAELTVARGGVATARIELSVPAGAPARDLTVPVSLGGQERTVTVRAYPPTGDTDLARGARATSSGDEAARFPASAAIDGDPRTRWSSRQRDDAWWQLELGRPVRLGRLVLHWQDAHPVRYRIQVSPDGRTWRDAAVVTDGKGGTESVRMDAPDARFVRVQGEKRATRFGYSLWTVEAYAVREPGKDGGAQQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN2</accession>
    <name>A0A2G1XFN2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20765</name>
        <name evidence="3" type="ORF">CYQ11_10015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50043">
        <property type="protein sequence ID" value="PHQ50043"/>
        <property type="gene ID" value="BLA24_20765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13179">
        <property type="protein sequence ID" value="PPT13179"/>
        <property type="gene ID" value="CYQ11_10015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="376" mass="39862" checksum="B4FA900D926B0B15" modified="2018-01-31" version="1">MSQDEDWQKDVLRSLRGLTEGPGEATEATEPPRPVAPPAGPPAQAVQPVPPARPPAGPPPRPLPTPVTMELPLPAELVKGKPLSGDSAARRTSRSLRRLVGSSATRDVEEATRTAQALQQPLTTGRQIVVTSIRGGAGKTTVTALLGRTYAHYRQDPVLMLEADAVLGTLPARLGVTKVRWTTSDLARILDPSMQLTDVVGYLVQAPGRGWLLPGSQGRVGNRLELAEYRAAMVALRRYFGVTVVDCDTLPSELSRTALSAAQARVLVTPATAEGVTSTRAVLDWMASVPRPRMLPGTVVVLTASSPHTTLDVAAASEHLRLDGVKVLALPYDRHLAGGGPVRTDLLGQGTREAVTELAAEVLTSAMSRRPSSSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN9</accession>
    <name>A0A2G1XFN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20840</name>
        <name evidence="3" type="ORF">CYQ11_09940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50054">
        <property type="protein sequence ID" value="PHQ50054"/>
        <property type="gene ID" value="BLA24_20840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13167">
        <property type="protein sequence ID" value="PPT13167"/>
        <property type="gene ID" value="CYQ11_09940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="455" mass="50335" checksum="75389C932DA3288D" modified="2018-01-31" version="1">MFSSPILLAFPFFLLLCFLLYWAGARHAYLRRPAVENGDPGAFDWHFFVPCRDEEAVVGTTVNRLRADHPDAHVWVIDDDSEDRTGAIVAGLAEEDRRVHLVRRHRPHARQGKGAALNAAYDELNDFLSKDVDRERVVVCVIDADGQLDPHALARVSGPQGFGDPGTGGVQVSVRMRNTDDPRPLGEDRGRIGNAVARLLVRMQDMEFSVSNAGMQLLRGRTGSVGLGGNGQFTRLASLDRIAAAERRPWQRGALLEDYELGLHMILSGDRISHIADTWVSQEGLPHGRRFLTQRTRWAQGNLQCVRYAPRIVSSRHYGGKGVLETLYTFLQPVAHLVTLALCAVMFAFLGLTTAREGAGEAFGGMLALWPLVVALAVVSVTPFVLWGPVYRRDRAADRSLLTALLWGLALWLYAYHLFPASARGFVRMLRGRNGWAKTRRNAESVESGPVAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG13</accession>
    <name>A0A2G1XG13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21625</name>
        <name evidence="5" type="ORF">CYQ11_09160</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50178">
        <property type="protein sequence ID" value="PHQ50178"/>
        <property type="gene ID" value="BLA24_21625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13039">
        <property type="protein sequence ID" value="PPT13039"/>
        <property type="gene ID" value="CYQ11_09160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="167"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="326"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="391" mass="41376" checksum="6314690F25343CAE" modified="2018-01-31" version="1">MPEPAARTPHPHSATLRNLEKSSGTLAAAAIARMDAQLPWYRAMPPENRSWIGLVAQAGIAAFTEWFRHPETPQAISTDVFGTAPRELTRAITLRQTVEMVRTTIEVMESAIDEVAAPGDTSALREALLVYAREIAFATAQVYAQAAEARGAWDARLESLVVNAVLSGEADEGALSRAAALGWNSPEHVCVVLGTAPNGDSELTVEAIRRAARHAKAQVLTGVLGDRLVVIAGGSDNPLQAAKALIGPFAAGPVVAGPVVGDLLAATRSAAAAAAGLKACAAWPDAPRPVLADDLLPERAMAGDPVAREQLVEEIYRPLEEAGSALLETLSVYLEQASSLEGAARMLFVHPNTVRYRLRRVTDVTGWSPSDVRSAFTLRIALILGRLADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG20</accession>
    <name>A0A2G1XG20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensor histidine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21655</name>
        <name evidence="6" type="ORF">CYQ11_09130</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50184">
        <property type="protein sequence ID" value="PHQ50184"/>
        <property type="gene ID" value="BLA24_21655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13033">
        <property type="protein sequence ID" value="PPT13033"/>
        <property type="gene ID" value="CYQ11_09130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="209"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="429" mass="45501" checksum="778C5CC59EC2FA39" modified="2018-01-31" version="1">MRQSPFLLLRDLFVPAGPPDPFLGRSRRPFVRRLPYLIAGAFVAALLPVTATLLPHEYGVNSDLAMALALAQTAPFLVAVRRPLLAWAIAFTACVAGALTLPPPLPGSTVVPWPPTAIIGMLLLMFAVGLRERLRTVAAVWVLVTVAGYLLDAGYRPRGNGSWLIPVILGGLLMLVGSALRKSSSAQQALAEQETISEAERARRTLLEERTRIARELHDVVAHHMSVITVQADSAPYRLTDLPDAAREEFASIAATARESLTEMRRLLGVLRSEEGGDGKERAPQPGVARVPQLVEATVRAGLPVELSMPGEGVPAPPQAVDLSAYRIVQEALANVVRHAPGAATRVSLSPDPGGEGLMVLVVNGASNDPDAPPLETSGTGHGLVGMRERVRLVGGTLDTGPLPDGGFRVAARLPFPHPTTTEEEPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG31</accession>
    <name>A0A2G1XG31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21710</name>
        <name evidence="3" type="ORF">CYQ11_09075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50192">
        <property type="protein sequence ID" value="PHQ50192"/>
        <property type="gene ID" value="BLA24_21710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13024">
        <property type="protein sequence ID" value="PPT13024"/>
        <property type="gene ID" value="CYQ11_09075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="191" mass="20098" checksum="D119DEF662324EB2" modified="2018-01-31" version="1">MGVTLAKGGNVSLSKAAPNLTNVTVGLGWDARSTTGAPFDLDASALLCASGRVLGDEYFVFYNNLKSPEGSVEHTGDNLTGEGDGDDESILVDLTKVPASCDKIVFPVSIHEADTRGQSFGQVSNAYIRVVNQADGSELARYDLSEDAAGETAMIFGEVYRYGGEWKFRAVGQGYASGLRGIALDFGVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG77</accession>
    <name>A0A2G1XG77_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SapB/AmfS family lantipeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21970</name>
        <name evidence="3" type="ORF">CYQ11_08815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50236">
        <property type="protein sequence ID" value="PHQ50236"/>
        <property type="gene ID" value="BLA24_21970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12979">
        <property type="protein sequence ID" value="PPT12979"/>
        <property type="gene ID" value="CYQ11_08815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045825">
        <property type="entry name" value="RamS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19402">
        <property type="entry name" value="RamS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="41" mass="4145" checksum="495D540022BC719B" modified="2018-01-31" version="1">MALLDLQSLESDESYSGGGHGGGSNASLLLCWSTASTVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGF6</accession>
    <name>A0A2G1XGF6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_22290</name>
        <name evidence="5" type="ORF">CYQ11_08495</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50285">
        <property type="protein sequence ID" value="PHQ50285"/>
        <property type="gene ID" value="BLA24_22290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12929">
        <property type="protein sequence ID" value="PPT12929"/>
        <property type="gene ID" value="CYQ11_08495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="24310" checksum="06B9FEFD8B1BCDE9" modified="2018-01-31" version="1">MSGTGTGAAPGGRPAERRGRPRSAAVDTTVVETVLRLLEEGVTVGELSMERIAREAGVGKATVYRRWADKEALLLDVLRSLDDACPELAGASVRDDLVALLEFLRRRVLAKRSSAVMRAVIAHVQTQPKLWREYHDTVVAARRQAFHAVLLRGAATGEIRPGLDAELLTDLFVSPMLSRVMLHEWRELPDGLAEQIVDTVLQGVRPQEGTAARGGPSRGNAPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGP4</accession>
    <name>A0A2G1XGP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20710</name>
        <name evidence="3" type="ORF">CYQ11_10070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50385">
        <property type="protein sequence ID" value="PHQ50385"/>
        <property type="gene ID" value="BLA24_20710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16466">
        <property type="protein sequence ID" value="PPT16466"/>
        <property type="gene ID" value="CYQ11_10070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="110" mass="11365" checksum="7D6C5BD4FB082448" modified="2018-01-31" version="1">MKFDMGSTTLSGLVSKTRGSSDDLGGLIRQLIVAAQPLEGKFNGAGKAAFDQFKSHSDEVTAALNSSLSAILGGQSGMDSSFGQGDQESADNARQQMAAANFDAARFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGQ7</accession>
    <name>A0A2G1XGQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Steroid C27-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21915</name>
        <name evidence="3" type="ORF">CYQ11_08870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50416">
        <property type="protein sequence ID" value="PHQ50416"/>
        <property type="gene ID" value="BLA24_21915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12987">
        <property type="protein sequence ID" value="PPT12987"/>
        <property type="gene ID" value="CYQ11_08870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="412" mass="45612" checksum="A0946FDA0F2E76E7" modified="2018-01-31" version="1">MPPCPALPEGFDFTDPDLYRRRVPLPEFALLRRTAPVWWNAQPYGSAGFGDDGYWVVTRHADVREVSTRPEVFSSHRNTSVIRFRPGIPSEHLDHQRLMMLNMDPPEHTRVRQIVQRGFTPRAVRALEGALRRRARAIVTAARERGSGDFVTDVACELPLQAIAELIGVPQEDRAKIFDWTNKMIAYDDPELAATEETGARSALELISYAMGLAAARAACPARDIVSRLVAAEDEGNLRSDEFGLFVLMLAVAGNETTRNAISHGMHAFLTHPEQWDLYKRERPATAAEEVVRWATPVTSFQRTATRDTRLGGADIAEGQRVGLFYASANHDPEVFDAPGTFDITRDPNPHLGFGGGGPHFCLGKSLAVLEIGLIFDAIADVLPGIRLAGEPRRLRSAWLNGIKELRVEYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX9</accession>
    <name>A0A2G1XGX9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16680</name>
        <name evidence="3" type="ORF">CYQ11_16605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50475">
        <property type="protein sequence ID" value="PHQ50475"/>
        <property type="gene ID" value="BLA24_16680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14270">
        <property type="protein sequence ID" value="PPT14270"/>
        <property type="gene ID" value="CYQ11_16605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="32065" checksum="3295AF58D1AB53F3" modified="2018-01-31" version="1">MATNESSGSVVRRILLGSQLRRLRESRGITREAAGYSIRASESKISRMELGRVSFKARDVEDLLTLYGVTDGAEREALLGLAREANVAGWWHSYGDVLPGWFQTYVGLEGAASDISIYEVQFVHGLLQTEGYAHAVIVRGQPKADAAEVERRVSLRMERQKLLFSERAPRLHVVLDEAALHRPYGGETVMRNQLQHLVDISEQPNVTLQVMPFAHGGHAGESGAFTMLRFPESDLSDVVYLEQLTSALYLDKAEDVAQYGRVMERLYADSLSPDDSREIIGRLLQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGY1</accession>
    <name>A0A2G1XGY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16795</name>
        <name evidence="2" type="ORF">CYQ11_16490</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50493">
        <property type="protein sequence ID" value="PHQ50493"/>
        <property type="gene ID" value="BLA24_16795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14252">
        <property type="protein sequence ID" value="PPT14252"/>
        <property type="gene ID" value="CYQ11_16490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="114" mass="11455" checksum="A2F5B22D5E107FE4" modified="2018-01-31" version="1">MRRSDDGYVTAETAVVLPTLTLLALALVWALMAAAAQIQCVDAARAGARAAARSDPPATAVAAARAAAPRGARVGLAREGDLVRVRVESRAAGPGPLAVSLRGEAVALAEETVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGY8</accession>
    <name>A0A2G1XGY8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16820</name>
        <name evidence="2" type="ORF">CYQ11_16465</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50496">
        <property type="protein sequence ID" value="PHQ50496"/>
        <property type="gene ID" value="BLA24_16820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14249">
        <property type="protein sequence ID" value="PPT14249"/>
        <property type="gene ID" value="CYQ11_16465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="369" mass="38064" checksum="368E3E7E7882FBDD" modified="2018-01-31" version="1">MTGSHASVRPASVDGRLAGPLIVTEDEGLLDDLLRLCAAAGAVPEVVHGMPARRGSWERAPLILVGEDCAPRLGGALRREGVVLVGRDRDDPDVWRRAVKIGALNVALLPDGEGWLVDRIADAVEGAGRPALTVGVIGGRGGAGASTLACALAVGAARAGRRTMLIDGDPLGGGLDVLLGGERAEGLRWPAFADSRGRMAGRALEEALPELHSLRVLSWDRGDCAAVPPEAMRAVLAAARRRGGAVVVDLPRRLDEAAMEAIGQLDMALLVVPAELRAVASAHRVSSTLAMMLSDLRAVVRGPCGSGLDGEEIARLLGVPLAGELPPEPGLAEALHAGKPPGGSRRSPLARFSAEFWARAFVGEGGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH23</accession>
    <name>A0A2G1XH23_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5063 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17065</name>
        <name evidence="2" type="ORF">CYQ11_16210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50532">
        <property type="protein sequence ID" value="PHQ50532"/>
        <property type="gene ID" value="BLA24_17065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14214">
        <property type="protein sequence ID" value="PPT14214"/>
        <property type="gene ID" value="CYQ11_16210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="222" mass="24197" checksum="51D540369A0EF495" modified="2018-01-31" version="1">MSDATLHDAKRDPDDFVVSVADSVESFIVAVTEVSRGDEPDSAVPFLLLELSQLLLTGGRLGAHEDFVPDERYEPDVGPEPDVDELRERFAAMLDPIDVYSELFDPYVPRSAPVACRISDDLADIITDLRHGMAHYRDGRVNEALWWWQFSYLTNWGPTASACLRALQSLVAHVRLDQPLGELDGLDTDAVGTEEQLAEEAGRLMAAEIGGAAKRASGAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK3</accession>
    <name>A0A2G1XHK3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17635</name>
        <name evidence="2" type="ORF">CYQ11_15640</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50619">
        <property type="protein sequence ID" value="PHQ50619"/>
        <property type="gene ID" value="BLA24_17635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14126">
        <property type="protein sequence ID" value="PPT14126"/>
        <property type="gene ID" value="CYQ11_15640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="194" mass="20994" checksum="BB1D769E763F8522" modified="2018-01-31" version="1">MGFLDVILGRSKPVRPDLDQLFALPSAAVTLQAGAGFSPTGLGSVCFASVEGGAFDRLQQEVRALLDADTGRGGAPVEFSRDSYGYTWLLTRQPAEDTAALVNDLHAVNTLLQDDGFGPQLLCSLMGFRGADGRSLALVYLYKRGTFYPFAPVAGRDGKRDNALELQVRALLGEDLRVEEDLSRWFPVWEAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHN1</accession>
    <name>A0A2G1XHN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18260</name>
        <name evidence="3" type="ORF">CYQ11_15015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50727">
        <property type="protein sequence ID" value="PHQ50727"/>
        <property type="gene ID" value="BLA24_18260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14017">
        <property type="protein sequence ID" value="PPT14017"/>
        <property type="gene ID" value="CYQ11_15015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="328" mass="33827" checksum="7E4ADCBDA23D9956" modified="2018-01-31" version="1">MYAITIPVPGGPEALVWAEVPDPVPGEGEVLVEVVASGVNRADIVQRQGFYDPPPGASPYPGLEVSGRIAALGPGVGGWAVGDEVCALLSGGGYAEKVCVPAGQLLPVPDGMDLVSAAALPEVTATVWSNVFMVAHLRPGETLLVHGGGSGIGTMAVQLAKAVGARVAVTAGGQDKLERCRELGADILIDYREQDFVEELRKVTGGVGADVILDIIGAKYLDRNLDALAVNGRLTIIGLQGGRTAELDLAKLLTKRAAVAGTTLRARPLTEKAAIVAAVREHVWPLIAGGRVRPVVDRTLPLRDAALAHAVLEESAHVGKVLLTTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI88</accession>
    <name>A0A2G1XI88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14140</name>
        <name evidence="3" type="ORF">CYQ11_13935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50935">
        <property type="protein sequence ID" value="PHQ50935"/>
        <property type="gene ID" value="BLA24_14140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13844">
        <property type="protein sequence ID" value="PPT13844"/>
        <property type="gene ID" value="CYQ11_13935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304662" evidence="1">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="39757" checksum="2E3BE1965E491491" modified="2018-01-31" version="1">MGERIINTTRKALAAAGVVAVIAAGTTACDPSDSLSPAAKVKQAFDKLGKQKSLSTEIGFNASADQIFKAMKDEKGFTREDADMLAGMRLAYSFGSDKALKDAESDDKSFKYGVALTLTGDKPMFEARQVDEKAYLRLDFKGLSSFVEKQQAKKGKKADAEDKAFQKLINDADQLPSSLASVKGALKGDWISLDPATFEEFAKSMDKGGDTKSAKPDPKTQKQIYEVLQRALTDNAEVKDAGKKDGIDHVKATVPAKKVAKDISEGLKPLKAKLGDKAGKLDELDRDLEKLDKKDDKNVTFDVSIKDGMLAGLTLDIGQFDTKAKGELPLSIGFKSGSGKVEAPAGAQELKPQDLMGAAMFVMGGGKDESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI99</accession>
    <name>A0A2G1XI99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPP34 family phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14385</name>
        <name evidence="4" type="ORF">CYQ11_13690</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50978">
        <property type="protein sequence ID" value="PHQ50978"/>
        <property type="gene ID" value="BLA24_14385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13800">
        <property type="protein sequence ID" value="PPT13800"/>
        <property type="gene ID" value="CYQ11_13690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="243" mass="25621" checksum="AFA6FCE7C95515A9" modified="2018-01-31" version="1">MNTDGAANLTLAEELLLLAHGPADGKKLCRPRTLEYGLAGAVLAELELRGQVTEDDGRPAVVVPALPPAPDPRLDWALASLTVPGDRPPKTHQWIRAAAKGQEEAVVMGLIERGALTVERQRFAVFRELRYPVGKTDLTNPARGRFEAARQEGFPDPRSRTLAALTDAIGITERLYPGWSGRRDRRPMRRLTRDGWIASAVHRNARSHSSDGTGSGGGDGGGHGCGGHGGHGCGGGCGGGCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XID5</accession>
    <name>A0A2G1XID5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_14435</name>
        <name evidence="7" type="ORF">CYQ11_13640</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50987">
        <property type="protein sequence ID" value="PHQ50987"/>
        <property type="gene ID" value="BLA24_14435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13791">
        <property type="protein sequence ID" value="PPT13791"/>
        <property type="gene ID" value="CYQ11_13640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="673" mass="71849" checksum="A8185CBCCF5B3435" modified="2018-01-31" version="1">MAERDAAPPAGHAAPPPVVSDRLGYRVKRLLLGPPLVTEQLTREKLSNPMALGVLASDCISSTAYGTEEILRILVPVAGIAAFSLLMPVTGAILLVLVLLTFAYRDVVSVYTRAGGSYVVARENFGPRVAQIAAVALLVDYIVTVAVQTAAGTDALISLAHLTGKGYTGIDHLKLPLTAAVVVVLMYGNLRGIREAGRAFAAPAYLFVLAIALVLAVGLARGLTGGLPRADVHAAGAVPLGSSDGGFLYGASLFMVLRAFANGGSSLTGLEAISNSVSAFRSPQGVNARRTLTVMSCVLGVMVLGVSALAHVTHAVPFEDGNPTVIAQEAHLVFGDGWAGTLGLVYVQLATALVLYTGANTPFTGFPFLASFVAEDRFLPRQLTRRGHRLAFSNGIICLTVVSLALVLVTRANVDKLVALYAIGVFTGFTMAASGMAAHYWRRRESHWKTGVNLTAAVVSALVVVIFAITKFTEGAWLVVVVFPLGVWALIRINREYRQEAEALENVPAFAAERPHWRRHVVYVLVDSLDLATIKALQYAHELRADEVRAVHFVIDETRARHLTARWDESSGTIVPLELVDCPDRRLRHAVAALAARATADGTTALTLLIPRRTYRNPLGRLLHRGTAEEMAKVLEQLPNVAVTILPLDVTSAIERLRAAREAAGESSDHHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIE9</accession>
    <name>A0A2G1XIE9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">rpoC</name>
        <name evidence="12" type="ORF">BLA24_14675</name>
        <name evidence="13" type="ORF">CYQ11_13395</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51024">
        <property type="protein sequence ID" value="PHQ51024"/>
        <property type="gene ID" value="BLA24_14675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13753">
        <property type="protein sequence ID" value="PPT13753"/>
        <property type="gene ID" value="CYQ11_13395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="11">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="962"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="972"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1299" mass="144720" checksum="2D23EBD3048B2283" modified="2018-01-31" version="1">MLDVNFFDELRIGLATADDIRTWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKVIYFAAYMITWVDEERRTRDLPSLEAHVSVERQQIEQRRDADLEARAKKLESDLAELEAEGAKADVRRKVREGAEREMKQLRDRAQREIDRLDEVWSRFKNLKVQDLEGDELLYRELRDRFGTYFMGAMGAAALQKRLESFDLDEEAERLREIIRTGKGQKKTRALKRLKVVSAFLQTRNSPSGMVLDCIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFVMKRLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILKPADGRPVTMPTQDMVLGLFFLTTDEEERKVIGEGRSFGSVAEAIMAFDARELSLQAKVDIRFPIGTVPPRGWVPPVAEEGEPEWQQGDSFRLRTTLGRALFNELLPEDYPFVDYSVGKKQLSEIVNDLAERYPKVIVAATLDNLKAAGFHWATRSGVTVAISDVVVPEAKKEIVKGYEAQDEKVQKQYERGLITKDERTQELIAIWTKATNEVAEAMNANFPKTNPIFMMVDSGARGNMMQMRQIAGMRGLVSNAKNETIPRPIKASFREGLSVLEYFISTHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREEDCGTDRGLKLAIAVKGEDGVLRKTDDVETSVYARMLAEDVVVDGKVIAPANVDLGDVLIGQLVAHGVETVKTRSVLTCESAVGTCAYCYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRVVELFEARTPKGVAPISEAAGRVRIEETEKTKKLVVTPDDGSDETAFPISKRARLLVSEGEHVEVGQKLTVGATNPHDVLRILGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDAELLPGELVERSRFESENRRVVTEGGHPASGRPQLMGITKASLATESWLSAASFQETTRVLTDAAINAKSDSLIGLKENVIIGKLIPAGTGLSRYRNIRVEPTEEAKAAMYSAVGYDDIDYSPFGTGSGQAVPLEDYDYGPYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIF5</accession>
    <name>A0A2G1XIF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14295</name>
        <name evidence="3" type="ORF">CYQ11_13780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50961">
        <property type="protein sequence ID" value="PHQ50961"/>
        <property type="gene ID" value="BLA24_14295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13817">
        <property type="protein sequence ID" value="PPT13817"/>
        <property type="gene ID" value="CYQ11_13780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="438" mass="47393" checksum="EFF40E2E176D474B" modified="2018-01-31" version="1">MGELLPFGDGLSPETRALAQALRELFAGLGISERRYAARRSYDSSTVSRYLSGQRMPSWEFVLNLLHDVAEERGTVPTAETTEMLRARHTAALKAGKSPTHKVQLLEQQLAVADQQARKVAARERWLEDTLRDREHRIRDLQMQLQAGPGPLGPEAGALGDDHVELRAEIEQLKQELARARALHRQAEERCEELERQLAEADRGEGEGAKPVGVVPEGDSVAGWTGTVIHGDVHVTTAGGWNVDEELVASATVSILTQGVLSNGLLVDRTTVVTSWASLSSVVMPAEAEVLDRWHGTRVPARVVERLPPEMGPVADSSRPYPGLAVLRLSRPWTAPTPALRLGRQPLPGSQLLVNASGGRDAETAGPYSCLLEVKGRTGSWLRVEGELVRGLWGAPAFNVATGELVGMVSSLNMTTQKGLLAPAEALLDLTTLNFTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIL7</accession>
    <name>A0A2G1XIL7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ORF">BLA24_15065</name>
        <name evidence="17" type="ORF">CYQ11_13005</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51094">
        <property type="protein sequence ID" value="PHQ51094"/>
        <property type="gene ID" value="BLA24_15065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13683">
        <property type="protein sequence ID" value="PPT13683"/>
        <property type="gene ID" value="CYQ11_13005"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="344"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="391"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ51094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT13683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="500" mass="52613" checksum="A178E5B6D3779C0A" modified="2018-01-31" version="1">MTDNVDGMPGKFAMLGLTYDDVLLLPGASEVLPNAVDTSSRVSRNVRVNIPLLSAAMDKVTEARMAIAMARQGGAGVLHRNLSIEDQANQVDLVKRSESGMVSDPITVRPDATLAEADALCAKFRISGVPVTDPAGKLLGIVTNRDMAFELDRSRQVREIMTPMPLVTGKVGISGEDAIELLRRHKIEKLPLVDDAGVLKGLITVKDFVKAEKYPNAAKDSEGRLVVGAAVGVGDEAYERAQALVEAGADFLVVDSAHGHSRGILDMIAKVKSNINVDVVGGNVATRDGAQALIDAGVDGVKVGVGPGSICTTRVVAGIGVPQVTAIYEAAQACHAAGVPLIGDGGLQYSGDIAKAIAAGADTVMLGSLLAGCEESPGEMVFINGKQFKSYRGMGSLGAMQSRGQARSFSKDRYFQDNVLSEDKLVPEGIEGQVPYRGPLSSVAHQLIGGLRASMGYVGSADVQELKDKGRFVRITSAGLKESHPHDIQMTVEAPNYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ55</accession>
    <name>A0A2G1XJ55_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16005</name>
        <name evidence="4" type="ORF">CYQ11_12070</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51253">
        <property type="protein sequence ID" value="PHQ51253"/>
        <property type="gene ID" value="BLA24_16005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13521">
        <property type="protein sequence ID" value="PPT13521"/>
        <property type="gene ID" value="CYQ11_12070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="419" mass="46454" checksum="51C33C82F2EC2F0E" modified="2018-01-31" version="1">MHTNHTPPAPPLFTWEFASDPYPAYAWLREHAPVHRTALPSGVEAWLVTRYADARQALADQRLSKNPVHHSEGAHGKGKVGIPGERSANLMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAPRVQELTDRLIDGFVARGEADLIHEFAFPLPIYAICDLLGVPAEDQDDFRDWAGMMIRHGGGPRGGVARSVKRMRTYLAELIHRKREDLGEDLISGLIRASDHGEHLTENEAAAMAFILLFAGFETTVNLIGNGTYALLRHPEQRERLQRALAEGDESLLATGVEELLRYDGPVELATWRFAVQDLVIGGQRIAEGDPVLVVLAAADRDPERFADPDTLDLARRDNQHLGYGHGIHYCLGAPLARLEGQTALATLLRRLPGMRLAAEPEDLRWRGGLIMRGLRTLPVAFEAGEPHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ56</accession>
    <name>A0A2G1XJ56_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15535</name>
        <name evidence="3" type="ORF">CYQ11_12540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51169">
        <property type="protein sequence ID" value="PHQ51169"/>
        <property type="gene ID" value="BLA24_15535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13607">
        <property type="protein sequence ID" value="PPT13607"/>
        <property type="gene ID" value="CYQ11_12540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="34306" checksum="25697101F1E20A32" modified="2018-01-31" version="1">MKGTLWLAWRQQRALVLGGGLLLALCAAWVVFQRPDAVAFVDEHHLAGCKGWDGGDEEGCDGEAFARLFDGGAGGLGALAALSVALPVLIGVFWGAPLLGREFENGTIKLALTQGVSVRRWFATRFALATVCAVTGSAVLAALVAWWWQPTANMLSGFYWHDGYIFNATGPAAVACAFFGLAAGTAAGLLMRRTLAAMGVTLAAVGGTRLLLNTFRSDWIAPTTRVTPGMTPKQPVGSAWSTGDFGYLDAAGREYPISRYCQTSGEDLRRCMAENGFVARYHKVHPVGDFWAFQWIETALFLGAAAALVAVTCLVLRRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ65</accession>
    <name>A0A2G1XJ65_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16285</name>
        <name evidence="2" type="ORF">CYQ11_11790</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51298">
        <property type="protein sequence ID" value="PHQ51298"/>
        <property type="gene ID" value="BLA24_16285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13476">
        <property type="protein sequence ID" value="PPT13476"/>
        <property type="gene ID" value="CYQ11_11790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024659">
        <property type="entry name" value="Phage_coat_Gp5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11651">
        <property type="entry name" value="P22_CoatProtein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="31707" checksum="CB4F3883CA8A2DFF" modified="2018-01-31" version="1">MVTLHDAVQDNDFAISHIVASGALSLLRGATGLANTVHRDAQEEFRGGVGDKVRIRRPEILEAKNFAGSVNAMAKPIKENTVELEITDQPLVATDLTDREMRFSIADFETQVTGPQAAGVADYLEQHIANTISARSAANALGLITMDPKNPRMAIIDAMTYLDKARVSGTRYLAVDPDVKNALMKDDNFSQVSQAGTAESLRGGVIGSAYGFVVVFSPYMKGAVAYVESAFAMAVCQPVAVRGTFSSGGSDRGYAMRWLLDFNGDTLKQRSVMDCYVGSTVLDERRSVGLALKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJM0</accession>
    <name>A0A2G1XJM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13715</name>
        <name evidence="3" type="ORF">CYQ11_01410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51448">
        <property type="protein sequence ID" value="PHQ51448"/>
        <property type="gene ID" value="BLA24_13715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16279">
        <property type="protein sequence ID" value="PPT16279"/>
        <property type="gene ID" value="CYQ11_01410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="69" mass="7840" checksum="6DA96E4A336F3D88" modified="2018-01-31" version="1">MTEATDLAQRAGDRDPRVGLRAVAALRRLLEQLEAVQVRSARIQGWSWQEIANELGVSRQAVHKKYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJW3</accession>
    <name>A0A2G1XJW3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13435</name>
        <name evidence="3" type="ORF">CYQ11_01155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51544">
        <property type="protein sequence ID" value="PHQ51544"/>
        <property type="gene ID" value="BLA24_13435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16274">
        <property type="protein sequence ID" value="PPT16274"/>
        <property type="gene ID" value="CYQ11_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="69"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="29068" checksum="89C23193B08FA6FF" modified="2018-01-31" version="1">MPPAVQETYGPADLGATPLFGGGFINFGHWQGIDLGPVLTEEDRIRSQRALYRHVLAALAPTEGLRAVEVGCGLGTGCAMALEEYGFAQVTGMDIHPQQLDRARRAQAALLADQADRLRFVQGAAESMPYGDAEFDRVYSVEAAQHFRDLDAFARETARVLKPGGRAAVTSFFVPDADPARPGQLAALLHTFATGLDVAHSIPELTGSLERSGLTDIRVTSIGAAVWHGWDRWLSTMWQPGTWPRNFLRAYDDGILDYFTVTAARPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK22</accession>
    <name>A0A2G1XK22_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12910</name>
        <name evidence="3" type="ORF">CYQ11_17270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51593">
        <property type="protein sequence ID" value="PHQ51593"/>
        <property type="gene ID" value="BLA24_12910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14386">
        <property type="protein sequence ID" value="PPT14386"/>
        <property type="gene ID" value="CYQ11_17270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="12802" checksum="CB50D485E3DCA039" modified="2018-01-31" version="1">METARHRQATEGVAVATTDTARPARPATLPAQPGTPEPPSGTIRYWAAAKAAAGTAEEPYAARTLADALAAARRRHEDEPEYARVLARCSFLVDGGPVGTRDHSTVQLAEGGTVEVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKB2</accession>
    <name>A0A2G1XKB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_12825</name>
        <name evidence="10" type="ORF">CYQ11_17180</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51579">
        <property type="protein sequence ID" value="PHQ51579"/>
        <property type="gene ID" value="BLA24_12825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14371">
        <property type="protein sequence ID" value="PPT14371"/>
        <property type="gene ID" value="CYQ11_17180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="294" mass="31796" checksum="FD49520A6639759B" modified="2018-01-31" version="1">MEDSARLLEGFEEHRPRLRAVAYRMLGSLSEAEDAVQETWLRFDRSVPAEVGNLGGWLTTVVGRVCLNMLRSRATRREDPLEAYIPDPVVSREDATDPEQEVLHADAVGLALLVVLESLAPAERLAFVLHDMFAVPFDEIAPLIERTPAATRQLASRARRRVQGQAPAPDPDPARQRAAVEAFFAAARDGDLEALVSVLHPDVVLRADGGVARARHTTVVRGARNVAAQAVTFTRFLPFVRPALVNGTAGVVVAANGRPLSVMAFAVTDGRVVAIDVIADPERLGRLSLPDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKR9</accession>
    <name>A0A2G1XKR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11660</name>
        <name evidence="4" type="ORF">CYQ11_02900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51739">
        <property type="protein sequence ID" value="PHQ51739"/>
        <property type="gene ID" value="BLA24_11660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11987">
        <property type="protein sequence ID" value="PPT11987"/>
        <property type="gene ID" value="CYQ11_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="319" mass="33223" checksum="1B0B809F902AE296" modified="2018-01-31" version="1">MDLEVRHLKVVCAIADAGSITKAAAALGASQPTLTAQLRRIERLLGGALFVRSRKGASPTALGEFVLARARSVLPSIESIQRESALHTGSTQARRPLRYVATPGPLAVGLVRELQELFPGALPTLRTEANMSTAAGLVASGQQDLAAVVEYVRSFAPGLPSGLRSATVAVEPVFVLLPATHPLAGRAAVGLAELADVEWTLPASLGNGLFESFSAACAEAGFTATVRHEAEAAAARELIADGQAVGLGQATFRGTPGVVPRPLEGMPLRVRHLLLWHGEGALAAHAPAVAARAERVYAAAVRRSPHYLDWLADHPVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL43</accession>
    <name>A0A2G1XL43_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10715</name>
        <name evidence="3" type="ORF">CYQ11_00835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51955">
        <property type="protein sequence ID" value="PHQ51955"/>
        <property type="gene ID" value="BLA24_10715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16267">
        <property type="protein sequence ID" value="PPT16267"/>
        <property type="gene ID" value="CYQ11_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="297" mass="30954" checksum="02A4EB3D464A8BA1" modified="2018-01-31" version="1">MTSSPRPPHVGGRPDPTDGTTALGGESASARGYLLDNARAEAGERFVWLAELFDGVTRGHLQRLGVRAGSRCWEVGAGGPGIPEALAAAVGPTGHVLATDIDPSWLKAGDGYEVRQHDVANDPPPEPGTFDLVHARLVLVHVPDRARALATMVAALRPGGWLLVEDADTALQPLACLDDSGPAQRRANRLRDAVRELLAGRGADLRYGRTLPRALREAGLVDVAAGGSFPVGGLACDRLEAATIRHVRGELLAAGLADGAEIDAHLAAVHAGELDLTLAPLISAWGRRPAEHPPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL74</accession>
    <name>A0A2G1XL74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_10490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000121">
        <property type="protein sequence ID" value="PHQ51977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51977">
        <property type="protein sequence ID" value="PHQ51977"/>
        <property type="gene ID" value="BLA24_10490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="143" mass="15848" checksum="140F6B4960B74AA0" modified="2018-01-31" version="1">MQGPIAKTVCRAPPAHPRGAFVPDNGGVLEMTREDFEELVAEGLDRIPQELTRLMDNVAVFVEDEPPAEAPDLLGLYEGTPLTERGEWYAGVLPDRITIYRGPTLRMCGSREEVVEEVEVTVVHEVAHHFGIDDERLHALGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL79</accession>
    <name>A0A2G1XL79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4937 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_01430</name>
        <name evidence="3" type="ORF">BLA24_10245</name>
        <name evidence="4" type="ORF">BLA24_10260</name>
        <name evidence="2" type="ORF">BLA24_30415</name>
        <name evidence="6" type="ORF">CYQ11_23510</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000113">
        <property type="protein sequence ID" value="PHQ51997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000113">
        <property type="protein sequence ID" value="PHQ51998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000022">
        <property type="protein sequence ID" value="PHQ53394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47829">
        <property type="protein sequence ID" value="PHQ47829"/>
        <property type="gene ID" value="BLA24_30415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51997">
        <property type="protein sequence ID" value="PHQ51997"/>
        <property type="gene ID" value="BLA24_10245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51998">
        <property type="protein sequence ID" value="PHQ51998"/>
        <property type="gene ID" value="BLA24_10260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53394">
        <property type="protein sequence ID" value="PHQ53394"/>
        <property type="gene ID" value="BLA24_01430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15454">
        <property type="protein sequence ID" value="PPT15454"/>
        <property type="gene ID" value="CYQ11_23510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032555">
        <property type="entry name" value="DUF4937"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16291">
        <property type="entry name" value="DUF4937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4937" evidence="1">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="22887" checksum="0D7280E3436332D5" modified="2018-01-31" version="1">MLVKWIRCTVVDRRGFERGQRKWAGLLGEPGFRGQGGGWSRARPDVVHLFGFWESRAFYDSFMARSHDRLAAAQSGTYKDIQVRLFEHRFDVKVGFQPQFTDADVVRFAHCRVREDRVEHFVLMQEKVWNPAMAGSPGMLRGVFGEAPGQEFLVLSMWNSVAEHGKYRTDRVERLGLRAQTEADVAAIGGDVIAIEPSWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL91</accession>
    <name>A0A2G1XL91_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_10195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000110">
        <property type="protein sequence ID" value="PHQ52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52005">
        <property type="protein sequence ID" value="PHQ52005"/>
        <property type="gene ID" value="BLA24_10195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1658"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3378"/>
            <end position="3453"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1693"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="3520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="3520" mass="364568" checksum="20D1F6FB7F300D7F" modified="2018-01-31" version="1" fragment="single">MGNEDKLRYFLKRVTADLEKAHERLRVMDARDQEPIAIVGMSCRFPGGVSTPEELWQLLATGGDGISDFPADRGWDLDTLFDPDPDRPGTSYVRKGGFLSAPAGFDAEFFGISPREAVAMDPQQRMLLETSWEALERAGIDPTSLRGGKVGVFAGTNGQDYAARLERSSDEVEGYLMTGGAASVLSGRVSYTLGLEGPAVTIDTACSSSLVALHLAAQSLRQGECTMALAGGVTVMGTPSVFLEFSRQRGLAADGRCKSFADAADGTGMAEGAGVLLLERLSDAQRHGHPVLAVLRGSAVNQDGASNGLTAPNGPAQRQVIEQALANARLSPEQVDAVEAHGTATTLGDPIEAHALLATYGQGRAEDRPLWLGSVKSNLGHTQAAAGVAGVIKMVMAMRHGVLPQTLHVDQPSTKVDWSAGAVRLLTEQQAWPVTGEARRAGVSAFGVSGTNAHVILEQAPAAEETDEPTPYAGPAVPWVLSARNAEALREQAARLAPLAATASPLDVGYSLATTRAALEHRAAVVAPDREGIAAGLAALAAGRPAAGVVEGVAGSGKLAVLFTGQGAQRLGMGRELIESFPAYAEAFDAVCAELDQYLDRPLREVVFGEDAESLDRTGFTQPALFAVETALFRLAESWGITPDCLAGHSIGELTAAHVAGVLSLADAAKLVAARALLMQALPAGGVMVSVAAPEADVRAATDDTHGVWVAAVNGPESVVISGDADAVTRVAESFSSAGVKTKRLRVSHAFHSGHMDGMLENFRKVAATLTYNAPRIPVVSNVTGGLATAEELCAPEYWVRHVREAVRFADGIAALSAQGVTRFLELGPDGTLSAMARECLPDPAAVLMPALRRDRPEAESLLSVLATLHVHGVDVDWRAFYEGSGARRVDLPTYAFQHQHYWPKDPVPSTGDVTAAGLNATDHPLLGAAMSLADDDGLLLTGLLSLRTHPWIADHAVMGAPLLPGTAFVELALQAADQVGCDRVEELTLEAPLVLPEHGSVQLQIHVSTADDSGRCAFTLYSRPAGAGTDEPWTRHAGGSLANGAVAGPAAELTVWPPAGAEPVALDGLYDGFAEAGLAYGPAFQGLRAAWRRGEETYAEVALPEQIASEATRFGLHPALLDAALHALGLSALAESGQARMPFAWGGVSLHAIGASVLRVRLAPAGTDTVSLTVADGTGAPVATVDSLTLRLITREQLAHGQRDSLFGVEWQSLVLAGGGAQGLVVESVASLADVSGAGGVPDVVVVPCVGAACGDVALGVREASGRVLGLVQGWLADERFASSRLVLVTRGAVAVGGEGVADLAHAAVWGLVRSAQSENPGRFVLVDADEELPADLLGAVVASGEPQVAVRAGAVRVPRLVRAVVPAGEQEPASWGGTVLITGGTGALGAVVARHLVAAGGVERLVLTSRRGPDAPGAVELRDELVALGAAEVTIAACDVADRDDLAGLLSRIEPPLSAVVHTAGVLDDGVVESLTAERLDTVLRPKVDAALNLHELTRDLDLSAFVLFSSAAGLFGAAGQGNYAAANAFLDALALQRRAGGLPAQSLAWGLWAQDGGMTGGLSEADVSRMTRAGLRPLSEAEGLALLDAARAVDDAVLAPIHLNTSVLAGQPELPVVLRGLVRAPAARRVADAGRGQESGLKERLLATPEADRERVLLDLVRTHVAAVLGHGSPDAVQPLRAFKEVGFDSLTAVELRNRLNADSGLRLPSTLVFDHPTPSAIAELLRAELLGDDLASAMPAPVSSSVAVDDDPIVIVGMSCRYPGGVNSPEDLWELVASGGDGVSPFPTDRGWELDGFFDSDPGRSGTSYAREGGFLHDAAEFDAGFFGISPREALAMDPQQRLLLETSWEALERAGIDPTSLRGSRTGVFTGVMYHDYGSRLQEIPEGLEGYLGNGSAGSVATGRISYSLGLEGPAVTVDTACSSSLVALHWAAQSLRQGECTMALVGGVTVLSTPGIFVEFSRQRALAADGRCKSFAGAADGTGWAEGVGMLLVERLSDAERNGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALESAGLAPEQVDAVEAHGTGTTLGDPIEAQALLATYGKKRAEGQPLWLGSVKSNIGHTQAAAGVAGIIKMVMAMRHGVLPKTLHVDEPSPHVDWSAGAVELLTEAVEWPETGEPRRAGVSSFGISGTNAHVIIEQAPAVTEEATAPDTDSAVPWVLSARSAEALREQAGLLASSVKDGSGSSRLDVGYSLATSRAMLEHRAAVVAADREGAVAALLALASGASAPGVVEGVADMRKLAVLFTGQGAQRLGMGRELHARFPVFAEAFDAVCAELDRHLDRPLREVVFGEDAELLDRTGFTQPALFAVEVALFRLVESWGVTPDFVAGHSIGELTAAHVAGVLSLADAAVLVAARARLMQALPSGGAMVSVAAPEADVLAAVEGVTGVSVAAVNGPSSVVVSGDEDAVLRLAGTLAESGVKTKRLRVSHAFHSGHMDGMLEEFGKVAATLTYHAPRIPVVSNVTGATAEELCAPEYWVRHVREAVRFADGIAALSAQGVTRFLELGPDGTLSAMARECVSEDALLVPALRRDRSEEQALLSALSTLHVHGTDVDWCAFYEGTGARRVDLPTYAFQHQRYWLDATKAAGDVTSAGLSSAEHPLLGAAVRLAEGDGHLFTGRLGVDTHAWLADHTVSDVIVVPGTAILEIAVRAGDQAGCRSVEELTLEAPLVLPERGAVQVQVSVSAVEDGGRCAFALYSRPEGAGTDTPWTRHASGTLAAGDTAPVAGLVVWPPENAEAVDIEGLYERFAAAGLTYGPTFQGLRAVWRRGEETYAEVALSETAASEARLFGLHPALLDSALHAMAAGDSNDSAQAHLPFSWSGVSLHATGASVLRVALSPAGTDAVSLTVADGTGQPVASVDALTIRPLSVEQLRAAAEPQQDSLFGVEWQSLVLAGGGAQGLVVESVASLADVSGAGGVPDVVVVPCVGAACGDVALGVRGAAERALGLVQGWLADERFVSSRLVLVTRGAVAVGGEGVADLAHAAVWGLVRSAQSENPGRFVLVDADGDLPADLLGAVVASGESQVAVRAGAVRVPRLVRAVVPAGEQEPASWGGTVLITGGTGALGAEVARHLVGGHGVERLVLTSRRGPDAPGAVELRDELTALGAEVEVVACDAADREALAELLGSLDSPLSAVIHTAGVLDDGVVESLTAERLDTVLRPKVDAALNLHELTRDLDLSAFVLFSSAAGLFGAAGQGNYAAANAFLDALALQRRAEGLPAQSLAWGLWAQDGGMTGGLSEADVSRMTRAGLRPLSEAEGLALLDAARAVDDAVLAPIHLNTSVLAGQPDLPVVLRGLVRAPAVRRVADAGRGQESGLKERLLATPEADRERLLLDLVRTRAAAVLGHTSQDALAPRAGFLDTGFDSLTAVELRNSLGSATGLRLPSTLLFDYPTPLALAQHLREQLFPNAGGAADVDPEEAELRAALASIPVSRFRQAGLLDVLLQLAQPESEIEEVHETGVTGLDLIDELNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL97</accession>
    <name>A0A2G1XL97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_10235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000112">
        <property type="protein sequence ID" value="PHQ52002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52002">
        <property type="protein sequence ID" value="PHQ52002"/>
        <property type="gene ID" value="BLA24_10235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04793">
        <property type="entry name" value="LanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033889">
        <property type="entry name" value="LanC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="451" mass="46928" checksum="6EE6B431470A94A3" modified="2018-01-31" version="1">MRSVVVNRGESRGGTAGIRREAAEVARAVAGRLAAFAGAAVETSGDGSAAHGSSLADGYPGIALALLHAGRTLDEPRLVDAAQALLRRSAQATAEEPLAGPGLYAGTAGFASVLLDFSVYDRRYLPSLRRIADRLGEQIAATPRLEPGAGLPVSDFDVISGAAGQLAAAVRLSTALDASPGDPVRVAAERLTEYLLRLTEPDDRRRFGWFTSPDYYPAYPGYEDQAPHGMYNLGFAHGLPGVISALCAAAAAGIGGPGPAERLAQTTAWLVENRLRDEVPGAAWPNLLRADEETGLPVAPLGQHPARAAWCYGAPGIGIALLSASKVLGDTALEATAAGALQRVVDWAPDERTVFSPNLCHGHAGLLAVYRRAHAVTGSASFRAMAEDSLSAVLSLADEARPYVVTDEPRRGEFADDPGLLNGAAGVLLALCGALAPQAAEWDELFFLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLD6</accession>
    <name>A0A2G1XLD6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Biotin synthase</fullName>
            <ecNumber evidence="2 9">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bioB</name>
        <name evidence="12" type="ORF">BLA24_09105</name>
        <name evidence="13" type="ORF">CYQ11_27715</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="2 9"/>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52074">
        <property type="protein sequence ID" value="PHQ52074"/>
        <property type="gene ID" value="BLA24_09105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16154">
        <property type="protein sequence ID" value="PPT16154"/>
        <property type="gene ID" value="CYQ11_27715"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="47"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ52074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT16154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="415" mass="43171" checksum="BE1A133B2244ABBE" modified="2018-01-31" version="1">MDLLNTLVDKGLRRELPTREEALAVLATSDDELLDVVAAAGRVRREWFGRRVKLNYLVNLKSGLCPEDCSYCSQRLGSKAEILKYTWLKPEEASEAAAAGVAGGAKRVCLVASGRGPTDRDVDRVSKTIAAIKEQNEDVEVCACLGLLSEGQAERLRAAGADAYNHNLNTSEATYGDITTTHTYADRVDTVQQAQAAGMSACSGLIAGMGESDEDLVDVVFSLRELDPDSVPVNFLIPFEGTPLAKEWHLTPQRCLRILAMVRFVCPDVEVRLAGGREVHLRSMQPLALHLANSIFLGDYLTSEGQEGKADLAMIADAGFEVEGAGTTTLPTHRADALAAAGCGSHGAGPGAGGCGSHGAAESAGGCGTGGGCGPCGDGGAVADAVAEPAPAGEARTDLVAVRRRGAGTDLPPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLI0</accession>
    <name>A0A2G1XLI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09135</name>
        <name evidence="2" type="ORF">CYQ11_27745</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52080">
        <property type="protein sequence ID" value="PHQ52080"/>
        <property type="gene ID" value="BLA24_09135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16160">
        <property type="protein sequence ID" value="PPT16160"/>
        <property type="gene ID" value="CYQ11_27745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="103" mass="11427" checksum="04D57E191D813D1C" modified="2018-01-31" version="1">MRWPPELPPLPALTRAEGELVDRYLEVLDLLGRINPARAHDTYGGLRAAQRLVVAAAELRDALTVMFERGEREVYAGTLARAMRVLDGERRAGRVALPPEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM9</accession>
    <name>A0A2G1XLM9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureC</name>
        <name evidence="13" type="ORF">BLA24_09160</name>
        <name evidence="14" type="ORF">CYQ11_27770</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. May also form a heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52174">
        <property type="protein sequence ID" value="PHQ52174"/>
        <property type="gene ID" value="BLA24_09160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16839">
        <property type="protein sequence ID" value="PPT16839"/>
        <property type="gene ID" value="CYQ11_27770"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="136"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ52174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT16839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="573" mass="60500" checksum="6C03D720BA5FCDD0" modified="2018-01-31" version="1">MSELSRVAYADLYGPTAGDRIRLADTDLLIEVEEDRCGGPGHAGDEAVFGGGKVIRESMGQSRATRAEGAPDTVITGAVVLDHWGIVKADVGIRDGRITGVGKAGNPDTMDGVHPDLVIGPETEVIAGNGRILTAGAVDAHVHFICPQAADEALASGVTTLVGGGTGPAEGSKATTITPGAWHLARMFEALEGHPLNIGLLGKGNTVSYDSMRAQLRAGAVGFKIHEDWGATPAVIDACLTVCEESGAQLAIHTDTLNEAGFVGDTLAAVAGRTLHAYHTEGAGGGHAPDIITVVSEPNVLPSSTNPTRPHTVNTVEEHLDMLMVCHHLNPAVPEDLAFAESRIRPGTIAAEDVLHDLGAISIISSDSQAMGRIGEVVLRTWQTAHVMKKRRGPLPGDGRADNLRARRYVAKYTVNPAVAQGLDHEIGSVETGKLADLVLWEPAFFGVRPHLVVKGGQIAYAQMGDANASIPTPQPVLPRPMFGALGRAPAATSLNFVTQWALDDGLPERLGLGKRFVPIRDTRGVTKADMRNNDARPRVEVDPDTFTVTIDGDPVEPRPAVELPMAQRYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMA6</accession>
    <name>A0A2G1XMA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07920</name>
        <name evidence="2" type="ORF">CYQ11_00355</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52368">
        <property type="protein sequence ID" value="PHQ52368"/>
        <property type="gene ID" value="BLA24_07920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11571">
        <property type="protein sequence ID" value="PPT11571"/>
        <property type="gene ID" value="CYQ11_00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="199" mass="22044" checksum="8090A6F152CC0DE3" modified="2018-01-31" version="1">MGADITALIVDWADLENIPVLEREGALIEAADPDVDDGGTEEGWAWLPPAPEGFPAWCARYEFASTRGSFKPHFWAGERWETVREHVAADLRSALDTFLGGLFWNLPGSEDDLQEEEDAEHWYGAMWVYCSPPDVLGLAQAWAEAGPRLEALRGPFDLHAAEPGTRVGRFEGFAMLLRGWAEVVDEAHRRGWGLVGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMF4</accession>
    <name>A0A2G1XMF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06620</name>
        <name evidence="2" type="ORF">CYQ11_26770</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52454">
        <property type="protein sequence ID" value="PHQ52454"/>
        <property type="gene ID" value="BLA24_06620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15986">
        <property type="protein sequence ID" value="PPT15986"/>
        <property type="gene ID" value="CYQ11_26770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="248" mass="25921" checksum="CBE04B396D0A3DF5" modified="2018-01-31" version="1">MPVRLDVQYQLATAPNGKAVDVHRPVTDAAVSPVALLWHGVSPDDRAMLRPLARAVAALGVLVLVPDWRSDASDGGREHLLASLEYARAHAPALGGDTDRFVLAGWSAGAPAALGIALHPELTGGWRPSAVVGVASRYDLPARTTGTAPLDDLAAAAPGTPVPVPVDLVHGTEDTLMDIGHSRRLLEALTAQRWPARLEAVRADHAGAAMTEYDPVLDRCRPSEKEEVRAAGELTALVIARAAGIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMF5</accession>
    <name>A0A2G1XMF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08075</name>
        <name evidence="2" type="ORF">CYQ11_00520</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52390">
        <property type="protein sequence ID" value="PHQ52390"/>
        <property type="gene ID" value="BLA24_08075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11593">
        <property type="protein sequence ID" value="PPT11593"/>
        <property type="gene ID" value="CYQ11_00520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="53815" checksum="3F4717E45668540E" modified="2018-01-31" version="1">MITSQDARLRAVSDLMVPATRTDAGRHEYDGLLQDLSPDGVRRGLAALGGSPVADPHDERQLSAFEHALWVRYGELELHRFDPTPHLENLDVTCYDREYAPAAERAAARRTHLAGWPDAVDAAIAALDRVPAPLAETALDTARGLAHLVTDEPPARAALDRLTTHLRHAARTGDPDPALGESALARLAGATEAVEVDLTALAARLDAERDAWRDRLIEACGRIDPAVPAEVTMAGILTDHPSPSGVLELAVELVAEVEAWTAERGLVPYLDGECRVGVTPPTDAHQVATLTMAAPYEPDGPSWFRITPPAPGWPADRSAQWLSLYNRSGLANIALHEAAPGHHAHGRALRRAAGDVRRTLHSAAFVEGWAHYCEQLAVEEGFRDGDPRFVASVARDALLRITRLACTIGFQARTMSVAEARHRFTVDALLAGPAADAAVHRVFREPLTMSYTWGKLAILDLRDRARAEWGSGFSLGRFHAALLGLGAPPLGLLDRALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMJ9</accession>
    <name>A0A2G1XMJ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07925</name>
        <name evidence="1" type="ORF">BLA24_10400</name>
        <name evidence="2" type="ORF">BLA24_10425</name>
        <name evidence="4" type="ORF">CYQ11_00360</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000119">
        <property type="protein sequence ID" value="PHQ51980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000119">
        <property type="protein sequence ID" value="PHQ51983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51980">
        <property type="protein sequence ID" value="PHQ51980"/>
        <property type="gene ID" value="BLA24_10400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51983">
        <property type="protein sequence ID" value="PHQ51983"/>
        <property type="gene ID" value="BLA24_10425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52369">
        <property type="protein sequence ID" value="PHQ52369"/>
        <property type="gene ID" value="BLA24_07925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11572">
        <property type="protein sequence ID" value="PPT11572"/>
        <property type="gene ID" value="CYQ11_00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="65" mass="7566" checksum="5E82310904306E3D" modified="2018-01-31" version="1">MGKTTMAADLSARHDFNVLPFDLTPDHQDLTHRYRTLLHQPGRLILDRCFLSELVYGPLRRGTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMK1</accession>
    <name>A0A2G1XMK1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YIP1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_06810</name>
        <name evidence="8" type="ORF">CYQ11_26960</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52485">
        <property type="protein sequence ID" value="PHQ52485"/>
        <property type="gene ID" value="BLA24_06810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16018">
        <property type="protein sequence ID" value="PPT16018"/>
        <property type="gene ID" value="CYQ11_26960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="20671" checksum="0111FE222EA5D7B5" modified="2018-01-31" version="1">MPVTTAPPPPTPAAKPRKLHWHRLIFGLWYRPVEVLDEARDRSVWGAAAFLSLLCGALGTLAKDSFWGQWDVSPVLALEAMAIGSVVMLLASLLLGAVTHAIARRLGGNGRFAPTASLFVVLFWASDLPRLALDTWLSAGSAPVRAAASVTAAFGCALATLLIRGQHHLPTHKAAASVSIQMLAAVVLLKFPPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMY2</accession>
    <name>A0A2G1XMY2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate--cysteine ligase EgtA</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthase</fullName>
            <shortName evidence="2">GCS</shortName>
            <shortName evidence="2">Gamma-ECS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">egtA</name>
        <name evidence="4" type="ORF">BLA24_06950</name>
        <name evidence="5" type="ORF">CYQ11_27100</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2 3">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52509">
        <property type="protein sequence ID" value="PHQ52509"/>
        <property type="gene ID" value="BLA24_06950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16044">
        <property type="protein sequence ID" value="PPT16044"/>
        <property type="gene ID" value="CYQ11_27100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02034">
        <property type="entry name" value="EgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017809">
        <property type="entry name" value="EgtA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035434">
        <property type="entry name" value="GCL_bact_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011556">
        <property type="entry name" value="Glut_cys_lig_pln_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378">
        <property type="entry name" value="PTHR34378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378:SF1">
        <property type="entry name" value="PTHR34378:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017901">
        <property type="entry name" value="GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03444">
        <property type="entry name" value="EgtA_Cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="45565" checksum="5686EC4F211C28B8" modified="2018-01-31" version="1">MDGLTRPVGESEADAYVRGICFKTGPPRLIGAELEWLVHDLREPTRPVAPHRLAAAAERVGALPLRSVFTVEPGGQLELSSRPAESLTACVEELSADLALARAELRGLGLALEGCGKAPWYEPPRVQSNPRYNAMEVYYDSINGAGRNVMCRTASVQVCVDAGTEEPGPMGYGRRWRMAHLLGAVLSAAFANSPLLLGRPCGWRSSRQACYARMDPGRSLAPPESHDPRAAWAAYALNANVMFVRSDGEPWAVQRGLALRQWARSGLPRPVTADDVAYHLTTLFPPIRPRGHLELRMIDAQPGEDGWIVPLAVTVALFDDPSAAETAYLTLKGLGDAPGPQRPPRNALWRRAARRGLSDPELHAAAVVCFAAAREALPRLGASPRVTEAVDAFIDRYVNRGRCPADDLLDRVAGGTGEGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XND8</accession>
    <name>A0A2G1XND8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05480</name>
        <name evidence="4" type="ORF">CYQ11_01940</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52726">
        <property type="protein sequence ID" value="PHQ52726"/>
        <property type="gene ID" value="BLA24_05480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11820">
        <property type="protein sequence ID" value="PPT11820"/>
        <property type="gene ID" value="CYQ11_01940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304745" evidence="2">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="483" mass="51541" checksum="D1FCD000C638EDA6" modified="2018-01-31" version="1">MKRSTIVQVLVWCAALVLGASACSGHGEPGGHSGTASARPLTGTQLVIATGVDVTGKNGIRKRLVDAWNELQEKENSPYRARAVILPGSADLQRSQLLAALQSGSSGYDIVNLDVTWVAEFAAAGLIRELPEEYADDGDVLAKAAATARWKGEVYAAPYNSDVGLLYYRRDYLVGGAGIDEKKSGALTTGHTMWGGVASLMDAVDAWARTDKTDKSKSYRSAWTSQLSPYEGLTVNGTEAFASAGVRLTGEDGAYAASPDELEKGVAEFRRRTENPHTLDDAFESDEAATLKDFAEGRTAFLRHWPYAYRTLHAALGDDKLGVAPLPGAAVLGGQDLAVAANPAMPEARVRKARELVRFLTDKTSERCLLDAGFAATRTSAYTDPGVTCDDHRAAPSAAASSEGSGGDMPRDRFQRPLYAKDTLLPALQAAVLRPHTPFYGAFTHAFTTELSRLHTSAKTRSMSDADVAKELDTALRKVLPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNF2</accession>
    <name>A0A2G1XNF2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52740">
        <property type="protein sequence ID" value="PHQ52740"/>
        <property type="gene ID" value="BLA24_05575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="109"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="225" mass="24011" checksum="7A3D854CCC3F4968" modified="2018-01-31" version="1">MRGGLRLSASRPVCGRGAPRTCLPRRWAPLPERAVRALAARPVPTRAGAGALLGRYLEQLAEQTGEDWPEADAARLGSAALDLATVLLGGLARADGLLAPESRQSVLRLRVKAFIRENLGSPGLTPRAIADAHGISVRHLHQLFREEDRSVSAPVRSSRLERCLADLGEPGLAHLPVAAVGARWGFTDPAAFSRAFKAAYGSPPGDCRRRRLALRRSGTRGPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNJ8</accession>
    <name>A0A2G1XNJ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05900</name>
        <name evidence="9" type="ORF">CYQ11_02375</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52793">
        <property type="protein sequence ID" value="PHQ52793"/>
        <property type="gene ID" value="BLA24_05900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11895">
        <property type="protein sequence ID" value="PPT11895"/>
        <property type="gene ID" value="CYQ11_02375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1663"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1624"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1751"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1631"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="2256" mass="232378" checksum="FF37A998C30B7F9B" modified="2018-01-31" version="1">MERTVIGVTPFGEPGARLAAAVSRAGGLGVLDLGAGGRAARDALEQLSEWAPGTFGVRVPAGCALRPEELPAPDATGPHTVLLAPGAPWRPGRAGPRTVLAEVCSLSEARAAVRAGAAGIVARGSECGGPAGRLSTYVLLQQLLADARVTVPVWACGGIGAHTAAAAVLGGAAGVVLDVQLALLDEACAPPALAELLRTLDGSETVVVDGRRILDPRRPGLPPLLREQPLPLGQDAFLARRFAERHRTAAAAVRAVRESVDRAVRAAHAPRALRPGSPMSRSLGTALPVAQGPMTRVSDQAGFAAAVAGAGGLPFIALALAGPADTRAVLAETRAALGERPWGVGILGFVPEDVRTAQLAAVRDARPSHVIIAGGRPSQAAELEADGIPAFLHVPSPGLLAQFLAAGARRFVFEGAECGGHIGPRNSFPLWEAQLAVLDDFLDARDGRAAPDPVEVLFAGGVHDERSAAMVAALAAGAGGRGVLTGLLMGTAYLFTEEAVECGAIRPVYQRQVLAAEDTTVLHNGPGHAIRCVPSPFGDTYRALKAELVERGVPESRAREELERLSLGRLRIAGKGIERVGEELVHVDERRQLDEGMFMAGEVAVLRGATTTVAALHHQVGEAAAAFYERRAAVLAEAAGAPSTTDGHARAPEPLDIAVIGMACMFPQAPDLAAFWANVLAGTDAVTEVPADRWDPALYHGEAAAAHDVTTSKWGGFLPRIPFDPLRYGIPPASLAAIEPVQLLSLEAARRALADAGYDRRDFPRDRTCVVFGAEAGSDTANATTLRAVLPSYLGRLPEELAAQLPVLTEDSFPGMLANVISGRIANRLDLGGANYTVDAACASSLAALDAACKELATGAADLALCGGADLHNGINDYLLFSSVHALSPTGRCRPFDAGADGIALGEGVACVVLKRLADAERDGDRVYAVVKSVGSAGDGRSLGLTAPRPEGQRAALERAYRQARTSPADVGLVEAHGTGTVVGDRTELATLTEVFEEAGAAPGGCVVGSVKSQIGHTKCAAGLAGLIKTALALRTGVRPPTLHVRRPNPAWRAEDSPFVFHDRALPWPGPAGRRVAGVSAFGFGGTNFHAVLGAHAGAAPPRHGHHDWPAELLVLRSPDDARELLRLTGLNDRAGRPWRLRDLALTAARRSGTQPPRAAVVADSLDALPGLLRAVLDAEPAPGVLLAGAPPADPARTPAGKVAFLFPGQGSQRPGMLADLFTAFPETQRRLRGAPAGDLFPPAAFDPGAAEAARARLADTRRAQPALGAVCLAVQDVLRTAGVRPDMAAGHSYGELVALCAAGALSPGSLMTLSIERGEAIVAAAGDDPGAMAAVAAAPDKADALLAEAGLAGRVVVANHNAPAQSVVSGPTADVERAVAVLRDTGVTARRLPVSCAFHSPVVAGAVDRFGRALATHEVRAPEIPVWSNVTAARYPLGSPDIRRTLAAQIASPVRFAEQIEAMYEAGARVFVEAGPGTVLTGLVRQVLDDRPHVAVPFEPRADAGLRGHLEALARLAVSGVPVAAARLLAGRGAVVADPEAVPARPGWTVDGHLVRTADGEPLPGALRPARRLAPAASPGPAVDTPVPVDESALVSEFLRTSREMVAAQKDVLLTYLGARAGGRATPDTPATAPLPPSTPPPAPPGTATPPKPAPEPPHAPSAAPDVLATVLAVISERTGYPVEIVEPDLDLEADLSVDSIKRTEIVGELGRRLGAATGRGLDVRAMPDAELEDLLRCRTAAAIADWLTTRLDTGPPPDTGRQDSEPAAPANAPPGRYLLRRVPLAPAPAEGSLHGQVFAVPGQDTPVARALVDRLRALGAVATRGDADPEAHPGPLDGAIHLDALAPGAEPVLPAAFPLFKALLGKKPRRLLCARPTGDPAHAAGLGGFFRTVAREHPGTLARVVALDPASPAEALADALVGELLATDPDPVVLRTPDGARYGTEPCEAPLARPAAAVPEDADPLLAEAAAAGLGPGSVVLLAGGARGIAAHLTTALAAAGCHLELLGRTVLPADPEDPALAAASDEAALRAALAARGGLRPALIGQETRRILARREVAATLAEAEALGSRPHYRAVDLRDAAAVREAVEDVHARHGRIDAVVHAAGVIEDRLLADKTPESFERVHGTKTEGARALLAALRALPEVPGLLVLFGSVAAVTGNRGQADYAAANDALATLGRQWRETTGGRALTVHWGPWAPTAAHTGMVTPELGREYARRGVGLIDPREGVLALLREIAGGDAATDEVVHTASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNT6</accession>
    <name>A0A2G1XNT6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">katE</name>
        <name evidence="17" type="ORF">BLA24_05990</name>
        <name evidence="18" type="ORF">CYQ11_02465</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52809">
        <property type="protein sequence ID" value="PHQ52809"/>
        <property type="gene ID" value="BLA24_05990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11911">
        <property type="protein sequence ID" value="PPT11911"/>
        <property type="gene ID" value="CYQ11_02465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="36"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ52809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT11911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="707" mass="77426" checksum="4F1C4E82FB8F23C3" modified="2018-01-31" version="1">MSAHHQSAGRGDPPAQDAKDQQLARFRAAPEHDALTTDQGVRVDDTDNALRAGTRGPTLLEDFHNREKLTHFDHERIPERVVHARGAGAYGYFEAYEPLTEYTCADFLAEAGRRTPVFVRFSTVQGPRGSADTVRDVRGFATKFYTREGNYDLVGNNMPVFFIQDAIKFPDFVHAVKMEPDNEMPTGGTAHDTFWDFASLQPETTHMLMWAMSDRAIPRSFRMMQGFGVHTFRFVTADGRGTFVKFHWKPKLGVHSQVWDEAQITAGRDPDYHRRDLWEAIESGEYPEWELGVQLVPEEDEFSFDFDLLDATKIIPEEQVPVRPIGRLVLDRNPQNFFAETEQVAFHTANVVPGIDFTNDPLLQGRNFSYLDTQLIRLGGPNFSQLPVNRPLADVNHNHRDGFGQQVIHPGTNYFPNSLGGGCPAHAGAGGGAGVFRHYAQRVDGEKIRVRSDSFQDHYSQAALFWNSMADWERRHIVEAFRFELGKVGSTQVRERMVGNLANVNAQLAEMVADGVGVAAPQPVSGVSTASSPALSQENLLGEGIRTRKVAVLAADGTDAGQVTAVRERLTAQGAIVEVLAAKDGSVRGSDGGGLDVDRALPTMASVLYDAVLVPDGKEAVAALAADPAAVRFVEEAYRHGKPIAVLGEGTRLLTEAKLPEEVVLGESAPDFGVLTGNGTTAPGDLADALATALGRHRFPRRPGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNX7</accession>
    <name>A0A2G1XNX7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05255</name>
        <name evidence="5" type="ORF">CYQ11_28275</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52955">
        <property type="protein sequence ID" value="PHQ52955"/>
        <property type="gene ID" value="BLA24_05255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11383">
        <property type="protein sequence ID" value="PPT11383"/>
        <property type="gene ID" value="CYQ11_28275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="25534" checksum="92F529C9E4CF772A" modified="2018-01-31" version="1">MSGALVCLPFAGGGAGFYRAWTDLPDGCPDIVPVQLPGREELFVDPPHTDAVTAAQALAPRIAELVGGYDSYALFGHSLGAVLAFEAARALSSLTGATAPDHLFVSGSPGPWSGRDDRATGLADREFLARVEQFAGYRHEALDDPEMRELLLPLLRADVEMHENYKPRSDEPLSVPVTSLRGASDTLVDAERAREWRHATTGAFRYAEIPGRHMYLVDTVAPLLETVTRVLAGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNY9</accession>
    <name>A0A2G1XNY9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04975</name>
        <name evidence="3" type="ORF">CYQ11_28555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52911">
        <property type="protein sequence ID" value="PHQ52911"/>
        <property type="gene ID" value="BLA24_04975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11428">
        <property type="protein sequence ID" value="PPT11428"/>
        <property type="gene ID" value="CYQ11_28555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304962" evidence="1">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="8178" checksum="FA909E6F77D3F410" modified="2018-01-31" version="1">MNHHFATRIAAGSVLLAVGGLACAAGTAQADDAHGRGTAPLTSRVAGLTSAGGPVGRAASLLKEEIPKEASGQVYLRSPLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPI6</accession>
    <name>A0A2G1XPI6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_01965</name>
        <name evidence="7" type="ORF">CYQ11_04325</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53136">
        <property type="protein sequence ID" value="PHQ53136"/>
        <property type="gene ID" value="BLA24_01965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12226">
        <property type="protein sequence ID" value="PPT12226"/>
        <property type="gene ID" value="CYQ11_04325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304766" description="D-alanyl-D-alanine dipeptidase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="29382" checksum="C118987E0C12D017" modified="2018-01-31" version="1">MVKLSAVCRALALPFAVLASLVSAPAAQAGPAPKAPPGFVSLAEVDPTIVQEMRYFTPHNFTGHRVDGYRRPTCLLTRPAAESLHRVQRAMLRRGLSLKVYDCYRPQRAVNDFVAWAKDLDDTRMKTEFYPRVDKSRLFADGYIAEKSGHSRGSTMDLTIVRLPALPTRPYVPGERLAPCFAPRSERFPDNSVDMGTGFDCFDTLSHTLDPRIQGRQRANRLLLKSAMEKAGFTNLAEEWWHYTLRDEPYPATYFDFPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPP4</accession>
    <name>A0A2G1XPP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_02375</name>
        <name evidence="8" type="ORF">CYQ11_04740</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53202">
        <property type="protein sequence ID" value="PHQ53202"/>
        <property type="gene ID" value="BLA24_02375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12294">
        <property type="protein sequence ID" value="PPT12294"/>
        <property type="gene ID" value="CYQ11_04740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="23769" checksum="0484A0967A379E91" modified="2018-01-31" version="1">MSALDWLSEEAFAAFGQHVIWSDMIGNCIGLAALALGWRRSVWTWPAQLLSGVVLITAYASAHLSGGVGKQLLVVTVALWGWRQWAGGRRQAQDGSIAVRFATWRERALLLGGTTVGTLAVGSLFTAVPELSWNPWPDAYIFIGTLAAMVAQARGLVEFWFAWLLVDVVGVPLAFDSGLAFSGLVYVVYLVLVLWGMRDWWLRSRTSATPATVTEGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ17</accession>
    <name>A0A2G1XQ17_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03140</name>
        <name evidence="3" type="ORF">CYQ11_05440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53313">
        <property type="protein sequence ID" value="PHQ53313"/>
        <property type="gene ID" value="BLA24_03140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12410">
        <property type="protein sequence ID" value="PPT12410"/>
        <property type="gene ID" value="CYQ11_05440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="24762" checksum="4A29B2001BE9898D" modified="2018-01-31" version="1">MSRILLKAFLGLLMRVLYRPRVEGAEHIADSGPVILAGNHTTFIDSLFLTLVLKRQVFFIGKDEYVTGKGFKGRLMAWFFSSSGMIPVDRDGGNGGVAALMTGRRVLEEGKVFGIYPEGTRSPDGRLYRGRTGIARLTLMTGAPVVPFAMIGTDKVQPSGKGLPRIAPVTVRFGEPLDFSRYEGMDRDRYVLRAVTDEVMSDVMRLSGQEYVDMYATKARAAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ21</accession>
    <name>A0A2G1XQ21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_02545</name>
        <name evidence="10" type="ORF">CYQ11_04870</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53338">
        <property type="protein sequence ID" value="PHQ53338"/>
        <property type="gene ID" value="BLA24_02545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16357">
        <property type="protein sequence ID" value="PPT16357"/>
        <property type="gene ID" value="CYQ11_04870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1691"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3774"/>
            <end position="3849"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1726"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="3925" mass="408043" checksum="6CC3B5817EF5B326" modified="2018-01-31" version="1">MTNTSGEAVVEALRDSLKEIARLRKQNERLATAREPVAIVATSCRFPGGVRTPEELWRMLAAGEDAVSGFPADRGWDLDALYDTDAGRSGTSYVRHGCFLHDVADFDAGFFGISPREATAMDPQQRLLLETSWEAFERAGIDPAGLRGSRTGVFVGSNGQEYGQIAEKAPNDELEGHVGTGSAASVASGRIAYSFGLEGPAITVDTACSSSLVALHLAVRALRDGECDLALAGGVRVLATPAPFVELSRQGALSPDGRCKAFAAGADGAGWAEGAGMLLVERLADARRLGHPVLAVVRGSAVNQDGASSGLTAPNGPAQQRVIRQALAGAGLTAADVDAVEAHGTGTRLGDPIEAQALLATYGQDRPTDHPLWLGSVKSNIGHTQAAAGVAGVIKMVEAMRHGLLPATLHVDRPTPHVDWSAGAVKLLSEPVPWRSDGRPRRAGVSSFGISGTNAHVILEEAPESEDGPAGDTGGRPAGLALSPLSARTEAALRAQAARLRQAVDADPGLAVHDVAHSLATGRTVFEQRAVVLADSRDGLLEGLAALAGDRPLPTVVQGAAEGDHRAVFVFPGQGSQWAGMAVGLLAESPVFAARMQECARALAPHVDWSLTDVLHDAGALERVDVVQPALWAVMVSLAALWRSYGVEPAAVVGHSQGEIAAACVAGGLSLEDGALVVALRSKALTALSGQGGMVSVALGEEEVRRRVRRWGERLSVAAVNGPHATVVSGAPDALEELRADCESAGVRARRIPVDYASHSAQVELIREELLALLAPVAPRTGSVAFFSTVTGETVDTATLDAGYWYRNLRETVRFGDAVLTLAGQGHEVFVEASPHPVLQAAIQEASDEVPGASLAVVGSLRRDAGGLDRFLTSVAEAHVRGVEVDRAAVFGGPGARRVDLPTYAFERRRHWAEAGPATGDVSAAGLEPAGHPLLGAAVPLPGSGGVLFTGRLSARTHPWLADHVVAGSVLLPGTAFVELALRAGEEAGCGRLDELTLAAPLVLDEEAATCVQVAVDGADEDGRRPLAVYARSADAGDEEEWTCHATGVLSPVTGHDRAAAAETSAWPPADAGPVALDGLYDRIAGTGIEYGPVFRGLRAAWRRGDEVFAEVRLPEEEHAAAARFGLHPALLDAALHAVGLGAVRDAGDGLLPFLFSGVRLHAVGSTALRVHLAPAGTDAVRLTVTDGSGLPVATVDSLVLRPVPHEKLRSRGGPRDALFRLDWPEFEPPAPGEPTAVVLGDDHLGLAGVLGLPSHPDVAALAEAAGTAPPDLAVVSFPGAGERLAESARAATARALELLQAWLADERLAGTRLAVVTRGAVAVRDGEDVPGLAAAPVRGLVRSAQAEHPGRFALVDLDGHDASPHALLAAALSDEPQTAVRAGAVHVARLARAAAAADAPPVLPEPDGTVLVTGGTGLLGGFVARHLVSAHGARHLLLVGRRGEAAPGMSELVAELRESGASVTVAACDVTDRAALTAVLAAVPAAHPLTAVVHAAGVLDDGVLTSLTPERLDAVLRPKVDAVLLLHELTREAPLSAFVLFSSATSTFGGQGQADYAAANAFLDALAQARRAAGLPARSLAWGLWEQRSEMSAHVGTADLARMGRAGALTLGREDGLALFDAALSVDEALLVPARVDLRGLRRSGGPVHPLLRALLPAPVRRAVTADGTDGGGSELVERLRGLPDAERRERLTELVRAHAAAVLGHAEADAVGPDRAFKDVGFDSLTAVELRNRLHAATGVRLPATLVFDHPTPVALAGFLTERVLGSAPRALAPVAAGSGAADGEPVAVVAMSCRFPGGVRSPEDLWQLVASDGDAMSAFPDDRGWDLAGLGGADGDGRGVEGGFLLDAAEFDPLFFGISPREALAMDPQQRLLLETSWEAVERAGIVPASLRGSRTGVFVGAMYQDYLLRLRNAPEEAEGYLGTGGSGSVISGRISYALGLEGPAVTVDTACSSSLVALHLAAQALRSGECELALAGGVAVMATVDLFTEYRRQQALSPSSRCKAFADGADGAAFGEGVGMVLLERLSDAHRNGHHVLAVIRGSAVNQDGASNGLTAPNGPSQERVIHAALTNARLTPADVDAVEAHGTGTRLGDPIEAQALLATYGQNRPTDHPLWLGSLKSNIGHAQAAAGIGGVIKMVEAMRHGTLPRTLHVDQPTTQVDWSAGAVEVLTEARPWPETGRPRRAAVSSFGVSGTNAHLILEHTPEEETAAPAEADRDGSPVPLVLSARTATGLRDQAARLHTHLTERPAARLTDVAHALATSRTHFEHRAVIPAGDRDEAVGGLEALATDGEFPGLLRARAADGQKVVFVFPGQGAYWPAMAAELLRTSPVFAEKAGECAAALEAHLDWSVLDVLSGAVEAPPAHRSDMIQPLLFAVTVSLAALWRSYGVEPSAVVGHSQGEVAAAHVAGALSLEDAARVVALRSRALLSLVGHGGMAAVAEPREELEARLERWRGRLSVAAVNSPRSATVTGSSDALDELLEELEAAGVRARRIRGADGAGHSAQVDTLRAHLLDVLAPVTPHPSAVPFYSTVYGEPVDTAGLDAEYWFLNARRPVEFERTTRALTAAGFRTFVEVSPHPLLSTPLQESADDVDVAVVGSLRRDEGGPERFLASVAEAHARGVRLDWSAVFAGQDARWTDLPTYAFERTHLWLHDGEPAGDVASVGLDPAGHPLLGAGVELPDTGGYLFTGRLSLRGHPWLADHGSPDVALLAGTAFVELALRAAERTGCSGVEELTLHQPLLLPEQDAVRLRVVVGGADDAGRRPVSVYARVEGTPADVPWTKHADGVLGRDGHGRPLDLTAWPPQGARPVDVEGLYERFADGGIVYGPSFRGLRAVWRRGDEMFAEVRLPQEERDSSDRYGLHPALFDAALHTLGLGAPVPGAGEGRNLLPFAWRGIALHATGAAGLRVRVAPDGEGGVSVHAADEAGGPVLSVDSLVLRPASAELLRPGGDALHDSLFRLTWTPVAPAEADEEAGWAVAGPDSWGLAEALRAAGTPVAGHADGRALAEAVAAGEAVPDVVLVPFPAGPDDGDDVAGTALEMTGRALALAQEWLSGERFADSRLVVVTRGAVATAPGEPAPDPVLAPVWGLLRSAQSENPGRIVLVDLDADGSSHRALPGALATGEPQLAIRAGRPLAFRLARAATSTALTLPSDTASWRLTPSADGTLEELSLGNGPDTGTPLADGEVRVAVRAAGLNFRDALIALDMYPGGDARLGSEGAGIVLETGPGVTALRPGDRVMGLLPGSFASTAIADQRTLVRIPEGWSYVKAASVPLVFLTAYYGLVDLAGLRAGESVLVHAAAGGVGMAATQLARHLGAEVYGTASRGKWDALRDLGFDDDHLGSSRDPGFEPRLRAATGGRGVDVVLNSLTGELVDASLHLLGPGGRFLEMGRADLRDPAAVAAGHDGVRYQAYDLSEAGMDRIHEMLIHVVDLLERGVLTPLPVRAWDLRHAKDAFRFLSQARHVGKMVLTVPRRLDPSGTVLITGGTGTLGGLVARHLVTRHGARHLVLAGRRGADAPGVAALAAELAGHGAELTLAACDVSDRGDVAKLLAGIPDGRPLTAVVHAAGALDDGVIDTLTPDRLDRVWYPKAEAAVHLHELTRDSDLSAFVLFSSSAGTFGGPGQGNYAAANAFLDAFAQARRAAGLPATSLAWGLWEERSEGTAALDDTDLTRIGRGGMAPLPTDEALALFDTGTDHADAVLLTARLHLAPLREQPLESVPPALRGLVRGRLRAAAGAQASEGGGTLADSLAGLPAHKQHGVLLQLVLRHVAAVLGHDSPDTVPADRSFKEQGFDSLTAVELRNRLATAVDLRMPATLVFDHPSPAALATYLRDLLVPEEPSGVETVLGELDRLATELDAFAEDDEARDAIAVRLQALTARWNATDTATATEDALESATDDELFDMVDKHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ40</accession>
    <name>A0A2G1XQ40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloride transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03030</name>
        <name evidence="3" type="ORF">CYQ11_05330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53343">
        <property type="protein sequence ID" value="PHQ53343"/>
        <property type="gene ID" value="BLA24_03030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16361">
        <property type="protein sequence ID" value="PPT16361"/>
        <property type="gene ID" value="CYQ11_05330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="76"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="36522" checksum="CA74C8FC74F3A96F" modified="2018-01-31" version="1">MHLSAMARFGGLLATDLRDVTSDPAALESTGWWAVVADFEGGLTCARFGDVRPAPAPAPGRWRGPDPRQWTSSLDHAAYTAGVRRIREHIAAGEVYQANLCRVLSAPLPDPAATDVDALTALLARGNPAPHAGTIRLPAHGVEVATASPELYLRRTGRTVESGPIKGTGRTAADLLEKDHAENVMIVDLVRNDLGRVCATGSVTVPALCAVEQHPGLVHLVSTVRGEIAPGAGWPELFAATFPPGSVTGAPKASALRIIDSLETAPRGPYCGGIGWVDADQGTGELAVGIRTFWIDREAAGGPALRFGTGAGITWGSDPEREWAETELKAARLLAIASAAHTPAEGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQE7</accession>
    <name>A0A2G1XQE7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_00595</name>
        <name evidence="9" type="ORF">CYQ11_07605</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53465">
        <property type="protein sequence ID" value="PHQ53465"/>
        <property type="gene ID" value="BLA24_00595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12770">
        <property type="protein sequence ID" value="PPT12770"/>
        <property type="gene ID" value="CYQ11_07605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131042" checksum="A37E81F8D593C284" modified="2018-01-31" version="1">MATKPPFTHLHVHTQYSLLDGAARLKDMFNACNEMGMTHIAMSDHGNLHGAYDFFHQAQKAGVTPIIGIEAYVAPESRRNKRRIQWGQPHQKRDDVSGSGGYTHKTIWAADATGLHNLFRLSSDAYKEGWLTKWPRMDKETIAQWSEGLIASTGCPSGELQTRLRLGQFDEALKSASEYQDIFGKDRYFLELMDHGIEIERRVREDLLEIGKKLGIPPLVTNDSHYTYAHEAEAHDALLCIQTGKNLSDPDRFKFDGSGYYLKSTEEMYAVDSSDAWQQGCANTRLVAEQVSTEGMFKAKNLMPKFDIPEGYTEVTWFREETMRGMARRFPGGIPEDRMRQVEYEMDTIISMGFPGYFLVVADFIMWAKKQGIAVGPGRGSAAGSIVAYALGITDLDPIPHGLIFERFLNPERISMPDVDIDFDERRRAEVIRYVTEKYGQDKVAMIGTYGTIKAKNAIKDSARVLGYPYAMGDRITKAMPADVLGKGIPLSGITDPNHPRYSEAGEVRGMYENEPDVKKVIDTARGVEGLVRQMGVHAAGVIMSSETITDHVPVWVRHSDGVTITQWDYPSCESLGLLKMDFLGLRNLTIMDDAVKMVKANKGIDIDLLSLPLDDPTTFELLQRGDTLGVFQFDGGPMRSLLRLMKPDNFEDISAVSALYRPGPMGMNSHTNYALRKNGQQEITPIHPELKEPLEEVLGVTYGLIVYQEQVQKAAQIVAGYSLGEADILRRVMGKKKPDELAKNFVFFKEGAQKKGFSDEAIQALWDVLVPFAGYAFNKAHSAAYGLVSYWTAYLKANYPAEYMSALLTSVRDDKDKSAIYLNECRRMGIKVLPPNVNESEANFAAQGDDVILFGLTAVRNVGQNVVDSIIRCRKSKGKYSSFPDFLDKVEAVVCNKRTVESLIKAGAFDEMGHTRKGLTAHYEPMIDNVVQVKRKEAEGQFDLFGGMDDESADEGPGFGLDVEFSDVEWEKSYLLAQEREMLGLYVSDHPLFGIEHVLNDKADAAISQLTGGEHADGAIVTIGGIISGLQRKMTKQGNAWAIATVEDLAGSIDCMFFPATYQLVSTQLVEDAVVFVKGRLDKREDVPRLVAMELMVPDLSNAGTNAPVVITIPTVKVTPPLVEKLGQVLSHHKGATEVRIKLQGARKTTVLRLDRHRVTPDPALFGDLKVLLGPSCLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQF3</accession>
    <name>A0A2G1XQF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00455</name>
        <name evidence="3" type="ORF">CYQ11_07465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53440">
        <property type="protein sequence ID" value="PHQ53440"/>
        <property type="gene ID" value="BLA24_00455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12745">
        <property type="protein sequence ID" value="PPT12745"/>
        <property type="gene ID" value="CYQ11_07465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="34605" checksum="8A72F1FBC4F9CE9B" modified="2018-01-31" version="1">MSDFADLARRALRDNGYSMGAAARAINYDLSYLSRVLNGKQQPSPKLAEALDQLVGAGGALSAVVLSADDRSRVSRSVERPSRLDAGTVEALGGVLAAYRRLDDALRPEAVIPATLTHVKDVTRMLKDARGPRRDQLTAVASEFAQFAGWMLAQVRRDDEAVSMLTQALELADSIEDGTLAAQALNFRGYLARQQGRQQGVARWFAAAAGTPGAHPAQRLGDLLQSAAGLAALGERDQALRAVEQAERLSDVAAAVPPPETAYWLTPEFNRLNMGLCTLALGRYDEAVDHISVGLAGLPEEQRGAAWTQEHRDALRRALAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQG1</accession>
    <name>A0A2G1XQG1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00535</name>
        <name evidence="3" type="ORF">CYQ11_07545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53453">
        <property type="protein sequence ID" value="PHQ53453"/>
        <property type="gene ID" value="BLA24_00535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12758">
        <property type="protein sequence ID" value="PPT12758"/>
        <property type="gene ID" value="CYQ11_07545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="76" mass="7681" checksum="FA218AA0DE7F3C8E" modified="2018-01-31" version="1">MSANSHGHTPAAWTGVTIAFIGFCVAGAFVVMAKPAGFLAGMAVVVLGGVVGGVMRMMGYGMVPKRGTQPQPQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQP1</accession>
    <name>A0A2G1XQP1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_01080</name>
        <name evidence="11" type="ORF">CYQ11_08090</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53554">
        <property type="protein sequence ID" value="PHQ53554"/>
        <property type="gene ID" value="BLA24_01080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12859">
        <property type="protein sequence ID" value="PPT12859"/>
        <property type="gene ID" value="CYQ11_08090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0033" evidence="9">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="461" mass="48067" checksum="E123994FB99E4D80" modified="2018-01-31" version="1">MPYFDAASAAPLHPVARQALLAALDEGWADPARLYREGRRARLLLDAAREAAAEAVGCRTDELVFTPSGTRALHDGIAGALAGRRRVGRHLVVSAVEHSAVLQSAAALDAAGGSVTEVTVDRTGRVAPDTYAAALRPDTALAVLQSANHEVGTAQPVAEVARECRAAGVPLLVDAAQTLAWEPAPEGWSLLAASAHKWGGPSGVGLLAVRKGVRFAAQGPADERESGRAPGFPNLPAIVAAAASLRAVRAEAVAEEARLRELVARVRAEVPRLVPDVEVVGDPVRRLPHLVTFSCLYVDGEVLLHALDRAGFSVSSGSSCTSSTLEPSHVLRAMGVLSEGNVRVSLPMGTAAKDVEDFLAVLPEVVASVRERAGAPAGTPAAAGGEARELVLDSLGKRCPIPVIELAKVIGDVPVGGLVTVLSDDEAARLDIPAWCDMRGQEYVGERPAERGVAYTVRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQX9</accession>
    <name>A0A2G1XQX9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000006">
        <property type="protein sequence ID" value="PHQ53591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53591">
        <property type="protein sequence ID" value="PHQ53591"/>
        <property type="gene ID" value="BLA24_00140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="109" mass="12545" checksum="2AC909BC5E988F92" modified="2018-01-31" version="1" fragment="single">EDEQQVFSVRTFYDRPHGIDEKSKLLEVIDDWNRRTLWPKVYTHTHDDGTVRLIGEAQMLIGVGVSLEHFVSSTVSWVRASIEFDKWLVEQLGLEADIESGDDKPDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X992</accession>
    <name>A0A2G1X992_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30280</name>
        <name evidence="4" type="ORF">CYQ11_23375</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47802">
        <property type="protein sequence ID" value="PHQ47802"/>
        <property type="gene ID" value="BLA24_30280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15427">
        <property type="protein sequence ID" value="PPT15427"/>
        <property type="gene ID" value="CYQ11_23375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="570" mass="59624" checksum="E320ECF08EF8E5CF" modified="2018-01-31" version="1">MDPVIVVGAGPVGLTLALALARYEVPVTVLDEASYRSAEQQEGRLARTVVLRPETAALLERLGCATTEGTRWTGWRTLHRRSVVAHVPFAAPGAGEAQRKPDETDDHEGDGDPGATPAEPSPLHLPQHALTRELCAALAGEADVRIVRDSRLTMLKQDPSGVTVHTGGDNGTQWRAGYLVGCDGARSVVRKLLGARFPGRTAVERHAVAALRAELPWPGEAVLHRSPPRGGEVTARPLPGGVWRLDWPLPPDGELVTPDALLARVNDALGVWCGEVPTYDLLDTGVHAVHHRLARRWRSGRAFLAGDAAHLLGALGTQGLDEGLKDAENLAWKLALAWHHGGSDALLDSYQAERRGAVAARLRAADRTLPAVRGQGGWRSVRRVVVPGAARGHDMVLTEGHLGRGLLGTPAVYARTPLVPAAPPASSVTVGTAIGEQVADVAVTAPDGSDTRLRDRLGGDLLVVLVAPGTGVWERRHWMGAGLMPRLAAAVSALPMAAELLVTEGYPGADAHTVLVVRPDGHLVAALAGVRPAELYACADAARGGAAGAGEAAGASEEEATAASEATANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9F1</accession>
    <name>A0A2G1X9F1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF485 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30515</name>
        <name evidence="4" type="ORF">CYQ11_23610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47848">
        <property type="protein sequence ID" value="PHQ47848"/>
        <property type="gene ID" value="BLA24_30515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15473">
        <property type="protein sequence ID" value="PPT15473"/>
        <property type="gene ID" value="CYQ11_23610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="19148" checksum="5335726374CD5FDB" modified="2018-01-31" version="1">MSPVCPSLGTRPTGSATEESSVGKREGRRAVTVQPPTGAESPHDAAGIYREVQRSAAFREVRGRYRRFVFPATVAFLLWYLAYVLAATLAPEVMARPVMGALNVAMLAGLAQFASTFLLTWAYARHARLRRDPAAMELRWAVTLETLQDTRPRRLELPAGRGPAAWRPAGGGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9J7</accession>
    <name>A0A2G1X9J7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF998 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30815</name>
        <name evidence="4" type="ORF">CYQ11_23910</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47898">
        <property type="protein sequence ID" value="PHQ47898"/>
        <property type="gene ID" value="BLA24_30815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15523">
        <property type="protein sequence ID" value="PPT15523"/>
        <property type="gene ID" value="CYQ11_23910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304755" evidence="2">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="212" mass="21981" checksum="44EB0FFC47CED1E8" modified="2018-01-31" version="1">MRARIGYAAWVAGVVQFFVAHGTVQAAWAQPYSWAANNVSDLGNAHCAMQPDPTPRYICSPEHGLMNGSFIALGTLLLLGVALTGRALWRQGRAAAAARVLLAGAGVGFVLVGLAPADVNENLHILGALLIMGTGNIGLLLAAFGLADNAPALLRRAAGLLSVLAVAAFGLFLSHHYLGLGMGGMERVALLPLLAWSFTVGLRGLLRPAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9R9</accession>
    <name>A0A2G1X9R9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31405</name>
        <name evidence="3" type="ORF">CYQ11_24445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47970">
        <property type="protein sequence ID" value="PHQ47970"/>
        <property type="gene ID" value="BLA24_31405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15594">
        <property type="protein sequence ID" value="PPT15594"/>
        <property type="gene ID" value="CYQ11_24445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="30518" checksum="74BAB9E59C1BAFBE" modified="2018-01-31" version="1">MTQSKDTDPYADPRAFYGSELKRLREGAGLTQEQLGQRVFCSASYIGQFETAVRRPQLELSQLLDDVLGSGEHLQRLCRLAHRSKVANYFADAAELEQRARTISEFSSMYVLGLLQTEAYAQAVTRSALRFVSQEARERLVSARRERAQLLEGPSAPAYWAIMHEATLRVAVGSPAVMAEQLNHLAEVVRALPNIVLQVMPFTAGAHHFLNSMVSLMHFNDAPPVVYTEGAGTGRLIEDPALVAHCQSSYDLARTEALPTAASLALIESAAKDWTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9U9</accession>
    <name>A0A2G1X9U9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31600</name>
        <name evidence="3" type="ORF">CYQ11_24650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48002">
        <property type="protein sequence ID" value="PHQ48002"/>
        <property type="gene ID" value="BLA24_31600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15628">
        <property type="protein sequence ID" value="PPT15628"/>
        <property type="gene ID" value="CYQ11_24650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="14377" checksum="DAD13A623E086510" modified="2018-01-31" version="1">MDAATPVVVRQGRRRPSGALEGEVLAALQRAGIPLTPREVQATLPGELTYSTVVTILSRLHGKEVLTRTPRGRAYAYAPLTDEAGLAARRMHKILDGRTDREVVLTRFADGLDEADAALLRQLLSDGLPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAB6</accession>
    <name>A0A2G1XAB6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5107 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32660</name>
        <name evidence="3" type="ORF">CYQ11_25710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48176">
        <property type="protein sequence ID" value="PHQ48176"/>
        <property type="gene ID" value="BLA24_32660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15802">
        <property type="protein sequence ID" value="PPT15802"/>
        <property type="gene ID" value="CYQ11_25710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033396">
        <property type="entry name" value="DUF5107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17128">
        <property type="entry name" value="DUF5107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="664" mass="71906" checksum="D175B0DD10F5175C" modified="2018-01-31" version="1">MSTTVRTAVLTLPAAPLGPENPLPPLSAPQDVHGPGAGLPDDLPPDMARQVRHGRLRSLLPVRRRDDYGRKRVPTDVTAIVVENDRLRATVLPEFGGRVHSLLHKPTGRSLLYTNPVLQPAGYALNGAWFSGGIEWNTGATGHGPLATAPLHAARLPAPDGGEMLRLWEWERLRDLPFQVDLWLPDGSDFLYAGVRVRNPHDRPVPVYWWSNAAVPEDARTRILAPADAAWSYGRERTLRRVPVPAHDGADHTYLLAGERSGDHFYDLPDGERRWVAALDGDGHGLVQTSTDLLRGRKLYAWGTAPADRRRQEWLTEPGTGGYAEVQAGLTRTQLEHVPLEAGGEFAWLEAYGPLTADPGRIHGPDWAAARAEAAGRLQAVLPRAAVDAAYAAWRPYADHAPKETLATGSGWGALEAERSGRELPGTPFPASALGDQQRPWQELLHTGVLTEDGRDPGPSLVSPHWRELLEAAEPGPYASYHLGVAQWHAGDRSQAVRSWECALRDGLDWPALRCLAAADRAAGHHERAADRYAAAARAARTGGATPAALTALTREAACALLAAGRADDAARIVEGVPAPARAHGRFRLLNARILLARGDAAGARAVFDEGFDVDDLQEGERTLADVWYAVAERLVAGPGPVTAEVRARARERHPLPARYDHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAE7</accession>
    <name>A0A2G1XAE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32685</name>
        <name evidence="2" type="ORF">CYQ11_25735</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48181">
        <property type="protein sequence ID" value="PHQ48181"/>
        <property type="gene ID" value="BLA24_32685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15807">
        <property type="protein sequence ID" value="PPT15807"/>
        <property type="gene ID" value="CYQ11_25735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038423">
        <property type="entry name" value="CAD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="427" mass="43533" checksum="39682B5E0C0A311A" modified="2018-01-31" version="1">MSVHFAEQHPAPASPAHPAGQLVAAGLGLQGQVPGILLGAKGHRIAAVAAGDYHSLAVTDDGALITAGLDDDEQVSGIFAAASGKAVFSVAAGGFHSLAVTHDGRLLAAGKDQNKQVSDILAAARGTPVAAVACAAVHSLAAARDGRILAAGWDGDGQVTGILDAARDVKVRAVAAGDFHSLAVTADGRLLAAGRDDDRQVSGILDAARGKRVVAVSAAALQSLAVTDEGELLAAGRDGNHQVSGILRAAQGLRIAAVAAGHLHSLAVTRDGRLLAVGKDSDKQVSGILAETKDKQVTAVAAGGYHSLAVLAPDGPRGRTVRVAFVAAHGPEQGVTLQFLEPEDGLDVRLYAGRPARDFAVREGVALRTAVRRDADGGEEVLGTGSVHFTYDELTGVAGLDTRASRFPSHLTCTSHGGNRFTFTWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF7</accession>
    <name>A0A2G1XAF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32930</name>
        <name evidence="7" type="ORF">CYQ11_25980</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48224">
        <property type="protein sequence ID" value="PHQ48224"/>
        <property type="gene ID" value="BLA24_32930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15851">
        <property type="protein sequence ID" value="PPT15851"/>
        <property type="gene ID" value="CYQ11_25980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="282"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="404" mass="42000" checksum="2148DB73C05A0434" modified="2018-01-31" version="1">MSTEAYVYDAIRTPRGRGKASGALHGTKPVDLVVGLIHELRRRLPDLDPAAVDDIVLGVVSPVGDQGSDIARIAAVAAGLPDTVAGVQENRFCASGLEAVNLAAAKVRSGWEDLVLAGGVESMSRVPMASDGGAWFADPMTNLDVNFVPQGIGADLIATLGGYSRRDVDSFAARSQELAAAAWKDGRFERSVVPVRDRNGLVVLDRDEHIRPGTTADTLAALKPSFAAVGEQGGFDAVALQQYHWVERIDHVHHAGNSSGIVDGAALVAIGNREVGERYGLRPRARIVSAAVSGSDPTIMLTGPAPATRKALAKAGLGIGDIDLIEINEAFAAVVLRFADEMGVGLDRVNVNGGAIAMGHPLGATGAMLLGTVVDELERRGGRFGLVTLCVGGGMGIATVVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAS0</accession>
    <name>A0A2G1XAS0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30545</name>
        <name evidence="4" type="ORF">CYQ11_23640</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48328">
        <property type="protein sequence ID" value="PHQ48328"/>
        <property type="gene ID" value="BLA24_30545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16752">
        <property type="protein sequence ID" value="PPT16752"/>
        <property type="gene ID" value="CYQ11_23640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="334" mass="35225" checksum="064EB0DD25CEFD71" modified="2018-01-31" version="1">MCLALSGCADDSSANSPGKHEEALKGDTVKIMVGGLDKVIYLPAVLTQQLGYFKDEGVNVRLLSEPAGVQATTSLVAGDVQGVVGFYDHTLDLQAKGKQVESVVQLAQTPGEVEVVSKEAAGEISSPKDFKGKKLGVTGLGSSTDFLTKYLAVKNGVQVGDVTPVAVGAGQTFISALQQGSIDGGMTTDPTVAQVVAKDLGKVLVDMRTPEGSKAALGGLYPSSSLYMNTGWVDGHKETAQKLANALVKTLKWMSEHSPEEIAAKMPEDYAKGGKELYVRSIESTLPMFTKDGVMPADGPKTVHEVLRSFNPAIKNASLDLEKTYTTEFVKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAU1</accession>
    <name>A0A2G1XAU1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48340">
        <property type="protein sequence ID" value="PHQ48340"/>
        <property type="gene ID" value="BLA24_31385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="436" mass="47295" checksum="89843E21E3DA8450" modified="2018-01-31" version="1">MSLPSVPRTGEAHGTDGPTVVAGTELVGEFEDSGYREPPHLVCRPDGQIVRLPTLLYAALRALAATPPGGGPPVMARVAEDLTRETGRTFTADHVAFLLDKKLAPLGLTTHSDGSPPPPTKKTDPFLAFRFRLAVVPEHVTWFLSGLFAWLFRPVAVVAMLGTFVACETWLWTTQNTGAALQSVLSSPANVLLVILLAVVSCAFHELGHGAACRYGGVRPGAMGCGIYLVWPAFYTDITNSYRLGRAGRIRADLGGVYFNALFVIAAGALYVATGWQLLLVAILSVHLEMIQQLLPTLRFDGYYIVADLVGIPDLFKYIAPILKRFVLRRPQDEQLRTLKRWPQIVVAVWVMFLVPVLSLQLGMVLVNLPELVQADWQRITALLANAGASGNPTLGVIAAVFQSLLLVLPVAGLALMLAQPARFLVRAAVRRLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB02</accession>
    <name>A0A2G1XB02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_28955</name>
        <name evidence="10" type="ORF">CYQ11_06520</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48414">
        <property type="protein sequence ID" value="PHQ48414"/>
        <property type="gene ID" value="BLA24_28955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12591">
        <property type="protein sequence ID" value="PPT12591"/>
        <property type="gene ID" value="CYQ11_06520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="352" mass="35829" checksum="E6F68B7E28695B32" modified="2018-01-31" version="1">MLVDSPPPPSPAPATPARRRGVSRNAARAAGLLLALGALLLVTVASVAVGAKQIPVDQVWHGLFHYAGSDTDVVVRDVRVPRTLLGLLAGAALGLAGAVMQALTRNPLADPGLFGVNAGAAAAVVSGISLLGVTSLTGYVWLAFLGAAAVSLVVYALGGTRGATPVRLALAGTAVTAALNGYIYSVELLDSAALDRMRFWTVGSLASANADLVGQVAPFVVVGVLLALALARPLNAMALGDDQARALGSRPALTRALALTAVTLLCGAATAACGPIVFVGLMVPHIVRSFTGPDLRWILPYAALLSPVLLLGTDIAGRVVVRPSELQVGVVTALVGGPLFIHLVRRRKMAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB52</accession>
    <name>A0A2G1XB52_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29385</name>
        <name evidence="3" type="ORF">CYQ11_06090</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48477">
        <property type="protein sequence ID" value="PHQ48477"/>
        <property type="gene ID" value="BLA24_29385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12525">
        <property type="protein sequence ID" value="PPT12525"/>
        <property type="gene ID" value="CYQ11_06090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="341" mass="36798" checksum="7D81100FDF915843" modified="2018-01-31" version="1">MSQANPPGLDLRRLRDHLGRARPGLVEGPLTAEVIAGGRSNLTYAVTDGTGRRWVVRRPPLGHVLATAHDMGREYRVISALRDTAVPVPGTVLLCEDAEVLGAPFYVMEHVEGTPYRTAAQLAAIGPERTRAVVRGLTGTLVRLHAVDPGAVGLGDFGRPEGFLERQLRRWGKQLEASRSRDLPGVDELCRALGAAPPASPAPTVVHGDYRLDNVLVGADDTVRAVLDWEMSTLGDPLTDLGLLMMYSEQRDVPGSPITTTREAPGHPDPAEIAEWYAAGSGRDVSALPWYTAFAYFKLAVILEGIHYRYTLGQTVGAGFDRIGQLVPLFIDSGLTTLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB55</accession>
    <name>A0A2G1XB55_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable subtilase-type protease inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sti</name>
        <name evidence="11" type="ORF">BLA24_29160</name>
        <name evidence="12" type="ORF">CYQ11_06315</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Strong inhibitor of bacterial serine proteases such as subtilisin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48445">
        <property type="protein sequence ID" value="PHQ48445"/>
        <property type="gene ID" value="BLA24_29160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12559">
        <property type="protein sequence ID" value="PPT12559"/>
        <property type="gene ID" value="CYQ11_06315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00778">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020054">
        <property type="entry name" value="Prot_inh_SSI_I16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00999">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="5 8 9" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8 9" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034593612" description="Probable subtilase-type protease inhibitor" evidence="8">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="site" description="Reactive bond" evidence="8">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="15137" checksum="370E90455E0C186B" modified="2018-01-31" version="1" precursor="true">MRYVTGGIALGAALALGGLVGIGTSASAAPTPIPPAHTQSLYAPSALVLTVGQGDSAAQAGVQRAVTLTCTPKATGSHPDASGACAQLRAAGGDFDKITTIKSGTFCTREWNPIVVTAQGVWEGKRVSYEHTFANPCEMKAGKGTVFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBG4</accession>
    <name>A0A2G1XBG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine/betaine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_29775</name>
        <name evidence="8" type="ORF">CYQ11_05700</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48541">
        <property type="protein sequence ID" value="PHQ48541"/>
        <property type="gene ID" value="BLA24_29775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12458">
        <property type="protein sequence ID" value="PPT12458"/>
        <property type="gene ID" value="CYQ11_05700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="604" mass="64341" checksum="60597361573DF42A" modified="2018-01-31" version="1">MPRINLGGWAEHAVSWLQAHLSWLFDAVNTVLSGMYDGVNATLGAPDALLMAGILAVVAWWLRGLPAAVLAFAGLALIDSFGLWDRATATLSLILVASVITLVLAVPLGIWAARDRRVSAVLRPVLDVMQTMPAFVYLIPGVMFFSIGPMPGLIATIVFSMPPGVRMTELGIRQVDAELVEAARAFGTTPRHTLTRVQLPLALPTIMAGVNQVIMLALSMVVIAGMAGAGGLGESVYAAVTQVDIGGGVESGLAVVVLAMYLDRMTGALGKRVSPLGRRASAKEAAPARGLASAKVLRYRPGTAVATVGVVVLALVAGGVQLVGGDGGRQAVAAGENVGQGQRMKLGYFPWDEAVASTYLWQNILEDRGYKPDVKQLDPGPLYTALAQGQMDVQFDAWLPTTHQQYMERYGDKLADLGAWYGPTSLELTVPSYVKDVDSLADLKGKAGTFGGKIVGIESSAGMMGKLNDKVLKEYGLDGEYKVVSSSTSTMLAELDRAIKKKQPIVTTLWSPHWAYGTYDLKKLKDPKGAWGEGEQIHAVGKKDFARDFPRVAGWLKNFKMSEADLSSLEAAVQKGGKGKEKDSARRWLDARPGLIDKLAPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBJ3</accession>
    <name>A0A2G1XBJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29940</name>
        <name evidence="5" type="ORF">CYQ11_05530</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48571">
        <property type="protein sequence ID" value="PHQ48571"/>
        <property type="gene ID" value="BLA24_29940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12427">
        <property type="protein sequence ID" value="PPT12427"/>
        <property type="gene ID" value="CYQ11_05530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="311" mass="33358" checksum="C7CE89BF0390BFA7" modified="2018-01-31" version="1">MHLPDMNLLPALDALLREGSVTGAAARMSVSASAMSRTLGRLRRVLGDPLLVPAGRGLTLTPRALELRPRVEAALVGALAALQPVQPVDIASVERRFTLRTNDGLAVVLGPALAERVAMEAPGIQLRWLPEGDEDPADLRGAIDLDIGHLPDLPHDVRSRPLARHRHVAVCRAGAPHADEPLTVERFAALPHITVTRRGRFHSVVDERLAELGLRRRVLATVPTHITACFLALRSDVLALLAAPVAARAAEAMPLVVREIPLPLPSIATGMAWHVRVDADPAHRWLRDAVAQAESPGPEDTRPAPEAAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBP7</accession>
    <name>A0A2G1XBP7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_28385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48638">
        <property type="protein sequence ID" value="PHQ48638"/>
        <property type="gene ID" value="BLA24_28385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="91" mass="9532" checksum="98407E387D912525" modified="2018-01-31" version="1">MVHPSQSERVGPAVVIGFSIALIVFSLLIMMLVLMHKGKGGGLSDMFGGGMQSSVGGSSVAERNLDRITIVIGVLWFACIVALGLLMKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBP8</accession>
    <name>A0A2G1XBP8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EstA family serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28540</name>
        <name evidence="3" type="ORF">CYQ11_06930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48663">
        <property type="protein sequence ID" value="PHQ48663"/>
        <property type="gene ID" value="BLA24_28540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12657">
        <property type="protein sequence ID" value="PPT12657"/>
        <property type="gene ID" value="CYQ11_06930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="384" mass="40166" checksum="996ABE6A28A267A0" modified="2018-01-31" version="1">MSEGIVAQGTVAEGFEAVRAEFEATLNEERAGHSAQLAAYADGQLVVDLWGGPGMAGDSLTGVFSSTKGAAHLVVALLVQEGVLELDRKVASYWPEFAAEGKGDITLRELLAHRAGLVGVEGGFTAEELADDRAIAARLAAERPYWRPGAGFGYHAYVIGALTGEVVLRATGQTMQEVYEARIRAPHGLDLYMGLPEDQEHRVLDAQPMDPTPEQKRALAEGQAGPQSLHGLAFNLNHPHPTDLQSLPNSRAVRAAGPASVGGVGSARGLARMYAAAVSGLDGKAPLLAPRTIAEFSQVHSAGQDLVFGQPNSFALGFAATSQLYRFLGARSFGHSGAAGSQAFADPGAGLAFGYNRRRFAFPGGAAPEAARLAKAVWEAVTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBQ1</accession>
    <name>A0A2G1XBQ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gap</name>
        <name evidence="11" type="ORF">BLA24_28370</name>
        <name evidence="12" type="ORF">CYQ11_07100</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48635">
        <property type="protein sequence ID" value="PHQ48635"/>
        <property type="gene ID" value="BLA24_28370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12686">
        <property type="protein sequence ID" value="PPT12686"/>
        <property type="gene ID" value="CYQ11_07100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="334" mass="36100" checksum="CCDC739467452FED" modified="2018-01-31" version="1">MTIRVGINGFGRIGRNYFRALLEQGADIEIVGVNDLTDNATLVHLLKYDSILGRLKQEVSHTDDTITVGSQTFKTMAERDPAALPWGELGADIVIESTGIFTKREDAAKHLAAGAKKVLISAPAKGEDITIVMGVNQDKYDAANHHVISNASCTTNCVAPMAKVLDENFGIVKGMMTTVHAYTNDQRILDFPHSDLRRARAAAENIIPTSTGAAKATALVLPQLKGKLDGIAMRVPVPTGSVTDLVLELDREASKDEINAAFQKAAEGQLKGVLEYTEDPIVSSDIVNWPASCTFDSSLTMVQGKQVKVVGWYDNEWGYSNRLVDLTVFVGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBT0</accession>
    <name>A0A2G1XBT0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28335</name>
        <name evidence="3" type="ORF">CYQ11_07135</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48629">
        <property type="protein sequence ID" value="PHQ48629"/>
        <property type="gene ID" value="BLA24_28335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12692">
        <property type="protein sequence ID" value="PPT12692"/>
        <property type="gene ID" value="CYQ11_07135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022118">
        <property type="entry name" value="Peptidase_C70_AvrRpt2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12385">
        <property type="entry name" value="Peptidase_C70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="25413" checksum="46F59B9BDA964819" modified="2018-01-31" version="1">MLLTRVRTRSSTTTPRHGRNAKMTRASASAPTEKSRIRGRRLSLAAIVASVLLAVPTTATAATGDQSSLLASKRLNIVMQAQQKNNWCWAASGNTIATWFGRTYSQNQFCNAAFNRQQGTECPNNQATLGNVQNALSWAGVNQGSYVSGWLRYSTVQSEINADRPVETRIQWSSGGGHMHVVYGYDDSNGWVYWGDPWPSSNRYNWASHNWYVGNDGFSWTHSLYRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC20</accession>
    <name>A0A2G1XC20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000158">
        <property type="protein sequence ID" value="PHQ48745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48745">
        <property type="protein sequence ID" value="PHQ48745"/>
        <property type="gene ID" value="BLA24_28145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="97" mass="9356" checksum="449E024DD50EB7B8" modified="2018-01-31" version="1">MTTVPAVSDVTTVVPVVTMTVAVSVVTSAVTTVARVAMTTVAASVAMTAVTTVVPVATTTAVVTVVAVPVVASALAVTMTVAVSVVTSAVTTVAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC48</accession>
    <name>A0A2G1XC48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27555</name>
        <name evidence="5" type="ORF">CYQ11_18090</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48827">
        <property type="protein sequence ID" value="PHQ48827"/>
        <property type="gene ID" value="BLA24_27555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14527">
        <property type="protein sequence ID" value="PPT14527"/>
        <property type="gene ID" value="CYQ11_18090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304568" evidence="3">
        <location>
            <begin position="29"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="351" mass="37165" checksum="699186C7C0607E57" modified="2018-01-31" version="1">MRPCLPGLAGSGIAAALIAMSVAVPAVADEGTAADTPSAFTIEDARVKESSGLAASRAHPGIYWTHNDSGDGAYVFAVDSRTGRTVARVTLEGVDPRDVEAISLGPDGNLYLGDTGDNLGGTWPEVWIYRFAEPKELKGEITVTPTRYTVRYDDGPRDAESLMVHPKTGRVYIVSKKKSGKGALYEAPETLSASGVNTFRRVADINTWATDAAFSPDGTRLVVRSYFEAREYLWKDGRPVKELGRPTVPLQRQGESVTFTLDGRYLMYGSEGARSRVTPVKLTGELLPDSAPEGDKGAGRSGRGGDQAASGDDGGGGHDRDPDLAVGAGLIAVVTALIVALRRLLRGKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC59</accession>
    <name>A0A2G1XC59_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27280</name>
        <name evidence="4" type="ORF">CYQ11_18375</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48781">
        <property type="protein sequence ID" value="PHQ48781"/>
        <property type="gene ID" value="BLA24_27280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14570">
        <property type="protein sequence ID" value="PPT14570"/>
        <property type="gene ID" value="CYQ11_18375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758461" evidence="2">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="34009" checksum="8ADE60833A366895" modified="2018-01-31" version="1">MRALPFLFSFLRPCALVRPSAALVRSTVLELAILTAHVLIYPTGILQERRPPTPPVPDTADMTVDVDTLDMLDVPSAPALRSDTPVRSDPPIRSDTPGPSDDMPGDRPPVLLLHGFIDNRSVFILLRRSLRRHGWRQVWSLNYSPLTCDVRTAAALLARHVEEVCARTGRQQVDMVGHSLGGLIARYYIQRMGGDARVRTLVTLGTPHGGTRVAPAMSAHPLVRQMRPDSEVIAELAAPAPHCATHFIAFWSELDQIMVPVETAAIDHPDLISRNVRVSGVGHLALPVHGEVAAGIRGALTAEQPAAGAAGAASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC71</accession>
    <name>A0A2G1XC71_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27660</name>
        <name evidence="3" type="ORF">CYQ11_17980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48843">
        <property type="protein sequence ID" value="PHQ48843"/>
        <property type="gene ID" value="BLA24_27660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14511">
        <property type="protein sequence ID" value="PPT14511"/>
        <property type="gene ID" value="CYQ11_17980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="21540" checksum="2B5441E69D6A2211" modified="2018-01-31" version="1">MRLFAAVVPPQAAVDELAAEVARLRAALPDRHGRLRWTEPALWHFTLAFLGEVDEALLPELGERLARAAHRHPVHELRFAAGGRFGDRILWIGATGSLETLRGLARSTRAGAGRAGVHVDDTKPFHPHVTLARTAGHVNLRPYTEELAEFRGRRWWVERVDLVRSHLPASGVPGERPRYETLTSWPLGTRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG8</accession>
    <name>A0A2G1XCG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28040</name>
        <name evidence="3" type="ORF">CYQ11_17600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48910">
        <property type="protein sequence ID" value="PHQ48910"/>
        <property type="gene ID" value="BLA24_28040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14441">
        <property type="protein sequence ID" value="PPT14441"/>
        <property type="gene ID" value="CYQ11_17600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="7938" checksum="E6373B099468CE01" modified="2018-01-31" version="1">MTTENGPGRWVWRKSSYCGSGAEGTDDCLEVADDITGLVPVRDSKNPQGPTLVFPASSWAAFLRTHKATESPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCY4</accession>
    <name>A0A2G1XCY4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23775</name>
        <name evidence="3" type="ORF">CYQ11_22295</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49103">
        <property type="protein sequence ID" value="PHQ49103"/>
        <property type="gene ID" value="BLA24_23775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15250">
        <property type="protein sequence ID" value="PPT15250"/>
        <property type="gene ID" value="CYQ11_22295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="84" mass="8808" checksum="478122773A4BA8F4" modified="2018-01-31" version="1">MSNDKQSALKKAKGFKKSKAGTYLSIGTTLFGAISVVKQAKKARGEQDTLQLVDAVVSAAAIATGVALLVRELRRMNSDDVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD52</accession>
    <name>A0A2G1XD52_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_23950</name>
        <name evidence="7" type="ORF">CYQ11_22120</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49131">
        <property type="protein sequence ID" value="PHQ49131"/>
        <property type="gene ID" value="BLA24_23950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15220">
        <property type="protein sequence ID" value="PPT15220"/>
        <property type="gene ID" value="CYQ11_22120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="5">
        <location>
            <begin position="51"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="236"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="398" mass="41670" checksum="8B9ACFF3E910F49C" modified="2018-01-31" version="1">MLPALLLGSVLTLVSACGGDDGGGKGGAKGSGKVADGPSQAVVDIAPKDGATDVATSGALKITAQKGSLTSVKVVDDKGHAVEGKIVNDGAAWEPASHLGASTKYSVDAIAKDEEGRTSAKHAAFTTLTPTNTFVGYFTPEDGSTVGVGMPVSINFSRGITDPKAVERAIKVTAEPAVDVKPHWFGNDRLDFRPEKYWAPGTKVTMAMNLNGVQGREGVYGTQTKTVKFTVGRSQVSTVDAASHTMTVERDGKVLKTVPISAGAPGHSTYNGQMVISEKYEVTRMDGRTVGFGGEYDISDVPHAMRLSTSGTFLHGNYWSGESTFGSENVSHGCVGLYDQRGGGDPSTPAAWFYDNSLVGDVVIVKNSDDKTIKPDNGLNGWNLSWAEWTKDSGGKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD89</accession>
    <name>A0A2G1XD89_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24305</name>
        <name evidence="3" type="ORF">CYQ11_21765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49192">
        <property type="protein sequence ID" value="PHQ49192"/>
        <property type="gene ID" value="BLA24_24305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15158">
        <property type="protein sequence ID" value="PPT15158"/>
        <property type="gene ID" value="CYQ11_21765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="110" mass="12590" checksum="7BF4A1957A84D6F9" modified="2018-01-31" version="1">MSPRRNRPRGGADPQTSLPRDGNSERYGLERTESWQGEEWAVRMIGGGAAAKHYRCPGCDQEIPPGVPHLVAWPRFGGGVEDRRHWHKSCWNAKDRRSARLQRSRNAPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDB6</accession>
    <name>A0A2G1XDB6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="8" type="ORF">BLA24_24465</name>
        <name evidence="9" type="ORF">CYQ11_21605</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49222">
        <property type="protein sequence ID" value="PHQ49222"/>
        <property type="gene ID" value="BLA24_24465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15127">
        <property type="protein sequence ID" value="PPT15127"/>
        <property type="gene ID" value="CYQ11_21605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="359" mass="39471" checksum="9A3298D8C5CA0DBD" modified="2018-01-31" version="1">MFEAVEELLGEHADLEKRLADPAVHADQANARKLNKRYAELTPIVGTYRAWKRTADDIETAREFAADDPDFAAEVKDLEKQREELTEKLRLLLVPRDPSDDKDVILEIKAGAGGDESALFAGDLLRMYLRYAERVGWKTEIIDATESELGGYKDVQVAVKTKGGNGATEPGQGVWARMKYEGGVHRVQRVPATESQGRIHTSAAGVLVTPEAEEVDVEINMNDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGVVASCQNEKSQLQNKEQAMRILRSRLLAAAQEKAEAEAADARRSQVRTVDRSEKIRTYNFPENRISDHRVGFKAYNLDQVLDGELDAVIQACVDADSAAKLAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDG9</accession>
    <name>A0A2G1XDG9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24815</name>
        <name evidence="4" type="ORF">CYQ11_21255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49284">
        <property type="protein sequence ID" value="PHQ49284"/>
        <property type="gene ID" value="BLA24_24815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15065">
        <property type="protein sequence ID" value="PPT15065"/>
        <property type="gene ID" value="CYQ11_21255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="15759" checksum="B85B3DB570C8413D" modified="2018-01-31" version="1">MSSKQSSSKTARKSTGGAPAAASAEPAGPRPARLSAAAALNGLEGVVLAGWGIYLLVMGLLGRPDSPQQAETGGLTVLALAALPLLAARGLWLRRRWSRGPALATQIMALPVAWMFFNGGGALIAAAVALALVAVATLALLVNPTATEALGIGPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDS3</accession>
    <name>A0A2G1XDS3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_25360</name>
        <name evidence="9" type="ORF">CYQ11_20715</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49378">
        <property type="protein sequence ID" value="PHQ49378"/>
        <property type="gene ID" value="BLA24_25360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14973">
        <property type="protein sequence ID" value="PPT14973"/>
        <property type="gene ID" value="CYQ11_20715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="28279" checksum="6A195E3F9EBC2A7B" modified="2018-01-31" version="1">MVGAPLDTTRADRGGAAAGGDRRGVLRRFRRSAAEPTSATDTADNSRAQDSATTATFATDAAPQAWTPPSWEEIVSTHSARVYRLAYRLTGNQHDAEDLTQEVFVRVFRSLSTYTPGTFEGWLHRITTNLFLDMVRRRQRIRFDALAEDAAERLPSREPSPQQHFNDTHFDADVQQALDTLAPEFRAAVVLCDIEGLSYEEIAATLGVKLGTVRSRIHRGRSHLRKALSHRSPAARAEQRAVAGVASGLPFGGEVGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE07</accession>
    <name>A0A2G1XE07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25805</name>
        <name evidence="2" type="ORF">CYQ11_20265</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49458">
        <property type="protein sequence ID" value="PHQ49458"/>
        <property type="gene ID" value="BLA24_25805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14892">
        <property type="protein sequence ID" value="PPT14892"/>
        <property type="gene ID" value="CYQ11_20265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="12764" checksum="4794CAE8B7C629D2" modified="2018-01-31" version="1">MKYPRTPEAEKAAREVVNRYVRQGDMRRADANRIMRDGLPIILNGFAEARIKGKPEAAITADLEAALAEAKQRQATARTATRRHMALLDLSTAEFAIAAWEGVRRDLANHLAAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE39</accession>
    <name>A0A2G1XE39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26050</name>
        <name evidence="3" type="ORF">CYQ11_20015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49500">
        <property type="protein sequence ID" value="PHQ49500"/>
        <property type="gene ID" value="BLA24_26050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14849">
        <property type="protein sequence ID" value="PPT14849"/>
        <property type="gene ID" value="CYQ11_20015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13779" checksum="1D62735B51DC16BA" modified="2018-01-31" version="1">MALASTGKALGAAEESAENPPVDTEGISLRTDSILAMRMGSTTREDIDEVTPAVVQHLNLLLDQDLGADEDAEVQQLVRKGLTLIDSKERPTAETPTFGAWLYARDVATLTRRLLWVYTERNGLGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XED6</accession>
    <name>A0A2G1XED6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4307 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26410</name>
        <name evidence="3" type="ORF">CYQ11_19230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49561">
        <property type="protein sequence ID" value="PHQ49561"/>
        <property type="gene ID" value="BLA24_26410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14719">
        <property type="protein sequence ID" value="PPT14719"/>
        <property type="gene ID" value="CYQ11_19230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="15000" checksum="086CFB7653DA0302" modified="2018-01-31" version="1">MAAEPQTLPEGRYGRSADERADRKLKIVGGVLLAVLLGFVGWAGVHYITKSDISAELVRRKTMSDDTVQVVLEIRKSKDSVGVCTLRSLGEDGSEVARKDVTLDRRESHFTELVTLRTTARAFATELEGCRDAPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEH7</accession>
    <name>A0A2G1XEH7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_26810</name>
        <name evidence="8" type="ORF">CYQ11_18825</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49630">
        <property type="protein sequence ID" value="PHQ49630"/>
        <property type="gene ID" value="BLA24_26810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14649">
        <property type="protein sequence ID" value="PPT14649"/>
        <property type="gene ID" value="CYQ11_18825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="23831" checksum="E07DF421CC77F1B7" modified="2018-01-31" version="1">MSSRIDRALVAGTALRLLNEVGLEGLTVRRIAKELNVQAPALYWHFKNKQELLDAVATEMFRRMAGSIAAAPRDTWQEYLAVNARGLRGFLLGYRDGAKVFGGTRFTDIDSYAAPVEQMMRVLVDAGFTPDAAARAWFTVNTYTMGYVMEEQSVFPDPATGERDPAYALDGRARRLEDYPLVDQAGHTFFGDMEKGFDEGLRAVVAGIEATLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEK7</accession>
    <name>A0A2G1XEK7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4328 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49652">
        <property type="protein sequence ID" value="PHQ49652"/>
        <property type="gene ID" value="BLA24_26930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025565">
        <property type="entry name" value="DUF4328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14219">
        <property type="entry name" value="DUF4328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4328" evidence="3">
        <location>
            <begin position="101"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="324" mass="34599" checksum="B3113C9CD25E79FA" modified="2018-01-31" version="1">MYPCGHCRAAAVGPDGRCAACGTYQQSLQAPMGAMPAAPPAYPYPGVPGGMPVGGVDLRRGVRVALIVMLSLMLPVTLLVMAARFAQADALETILDHGPLFLDRGKVEDADDFYAVAILLYFLTLAATATLWAVWFRRTRVNAEVFAPGTHRFGTGWAAGAWFTPVVNFWFPKQIANDIYRASSPTGPQNVRKGLLNAWWVLWIAATACNVVSSALYSVATNRNTYDGSDWHDNVSALKSSVNLSGLAFLLYFVAALLAILVVRQLTKMQEQRAAMGPQPMAPMGGMPYGAPAAPGFPPAPPYGAPYPPHGQPQNPFGSGPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEN6</accession>
    <name>A0A2G1XEN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3515 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23480</name>
        <name evidence="2" type="ORF">CYQ11_22590</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49697">
        <property type="protein sequence ID" value="PHQ49697"/>
        <property type="gene ID" value="BLA24_23480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16727">
        <property type="protein sequence ID" value="PPT16727"/>
        <property type="gene ID" value="CYQ11_22590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="16204" checksum="1DB5B98632650517" modified="2018-01-31" version="1">MPAVVALLFACAACSGADDEAGPAVPTPSGRQAALCRALHGALPRTVGDLERRATDPESDFTAAWGGHPAITLRCGVPKPELLRSHPGSDSAELNGVEWLPEKQSDGSVRCTTVQREAWVEVTLPKKVVGDVGAGDISVLTDLADAVSKTIPVGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XET9</accession>
    <name>A0A2G1XET9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25925</name>
        <name evidence="2" type="ORF">CYQ11_20145</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49740">
        <property type="protein sequence ID" value="PHQ49740"/>
        <property type="gene ID" value="BLA24_25925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16686">
        <property type="protein sequence ID" value="PPT16686"/>
        <property type="gene ID" value="CYQ11_20145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008841">
        <property type="entry name" value="Siphovirus-type_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05709">
        <property type="entry name" value="Sipho_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="262" mass="28136" checksum="C3AD4A5BF8A58A5A" modified="2018-01-31" version="1">MTGFGFQATAGMTGRGLPAVDVQWLSGAGDGARWRGQRVQPRDLDIPLDILGRDRSHLSELVSRLAQAVAGECQLVLVDDQGVRWSTSVYRTGGGDITDDGTSSLQTVITFRAPDPYFVASSVSTQSVGGDPGKRPFLSSLASLPLAASQAIGDVQLDNTGDVPAYPVWEVYGPGRDLTVMAPTGETLRWQGTLAIGERLIVDTRNGSVRDGKNVNRYADLAAAPRFWTVPPGTSTASVRMLDTTADSRIVCSWRPRKWMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEX3</accession>
    <name>A0A2G1XEX3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">raiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="4" type="ORF">BLA24_19215</name>
        <name evidence="5" type="ORF">CYQ11_11585</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49782">
        <property type="protein sequence ID" value="PHQ49782"/>
        <property type="gene ID" value="BLA24_19215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13442">
        <property type="protein sequence ID" value="PPT13442"/>
        <property type="gene ID" value="CYQ11_11585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="24946" checksum="B91148F5706C31A7" modified="2018-01-31" version="1">MDIVVKGRKTEVPERFRKHVAEKLKLDKVQKLDGKVISLDVEVSKEPNPRQSDRSDRVEITVRSRGPVIRAEAAATDPYAALDLAAAKLEARLRKEHDKRHDRRGNGRIPASGVAATVIGAAGINASGELTTEQGEGEVPVTHIGPLEIRGEGPLVVREKTHSAAPMTLDQALYEMELVGHDFYLFVDSETKMPSVVYRRHAYDYGVIHLNADPLFEGEPGGAGGELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEY3</accession>
    <name>A0A2G1XEY3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_19245</name>
        <name evidence="2" type="ORF">CYQ11_11555</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49788">
        <property type="protein sequence ID" value="PHQ49788"/>
        <property type="gene ID" value="BLA24_19245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13436">
        <property type="protein sequence ID" value="PPT13436"/>
        <property type="gene ID" value="CYQ11_11555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="17651" checksum="7938DEF4786500DD" modified="2018-01-31" version="1">MRVYVPLTLPGLAEAYEAGELGPAPLDAYAVTPALREWYVSDDIEELEYAALSRAAQGSLRMLAGDPAAARRRVVVAVDVPDRLVAADPDRALDQSALGEVRLADPVPLKKAASVHVDSDDAEEDVAAAAAALGAADQGDDDAQFTVDGAEDHELMWFGVQEIPNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEZ8</accession>
    <name>A0A2G1XEZ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19345</name>
        <name evidence="5" type="ORF">CYQ11_11455</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49808">
        <property type="protein sequence ID" value="PHQ49808"/>
        <property type="gene ID" value="BLA24_19345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13416">
        <property type="protein sequence ID" value="PPT13416"/>
        <property type="gene ID" value="CYQ11_11455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304915" evidence="3">
        <location>
            <begin position="33"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="29048" checksum="2F26BC99D018BFC6" modified="2018-01-31" version="1">MTKKTRLRVARIAAGAVIAAGASLTAAGAASAAGVDVEVPGVGIKAGVNVDGPTTGPTTGPTEIPQPTNPGTTGGTTTGGTTTGGSTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGATTGGTTTGGATTGGETTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGSGSTGGDHGTTGGSGTTGGGDHGSTGGSGATGGGDHGTSGGSGSTGGDQSGSAATGGNGGDSGDDVRTCPVDTDGNCNTGTDNAGSQPVQQAKPKEELAHTGELAETGAGQTTFLLVGAATMIAGGIGFRMLPRLINRNTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFA4</accession>
    <name>A0A2G1XFA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_19990</name>
        <name evidence="2" type="ORF">CYQ11_10800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49913">
        <property type="protein sequence ID" value="PHQ49913"/>
        <property type="gene ID" value="BLA24_19990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13312">
        <property type="protein sequence ID" value="PPT13312"/>
        <property type="gene ID" value="CYQ11_10800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="121" mass="13409" checksum="2174E4BE28DDBC83" modified="2018-01-31" version="1">MCEPRQAPGAADSGPRRLKPAQLLFEPPEAVADPEHFFDLESIEDPRELLARSTELALAFRAAADRATEYQAVAAAQLADPRRFDRLPTAVIAERAEWSEDYAKKMVEFGRDLLRGGSPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFA7</accession>
    <name>A0A2G1XFA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19815</name>
        <name evidence="3" type="ORF">CYQ11_10975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49885">
        <property type="protein sequence ID" value="PHQ49885"/>
        <property type="gene ID" value="BLA24_19815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13339">
        <property type="protein sequence ID" value="PPT13339"/>
        <property type="gene ID" value="CYQ11_10975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="30919" checksum="A3CD3B669D2CDE0E" modified="2018-01-31" version="1">MRLLRVGPAGAERPALLEEDGTLRDLSALVRDVDGALIGDEAALSRIRAAAGARILPALDPHGLRIGPPLGRIGKIVGIGVNYRDFVATARMATPAEPVLFLKAPDTVVGPDDTVLVPRGSEKTDWEIELAVVIGRTARSLRTDDEAMAAVAGYALVNDVSEREFQNERGGQWDKGKNCETFNPLGPWLVTADEIRDPQDLRMRLWVNGALMQDSSTAEQIFPVAFLVRYVSRFMTLYPGDVINTGTPAGVAVSRPAPKPYLRAGDVMELEIEGLGRQRQQVKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB7</accession>
    <name>A0A2G1XFB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19875</name>
        <name evidence="4" type="ORF">CYQ11_10915</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49895">
        <property type="protein sequence ID" value="PHQ49895"/>
        <property type="gene ID" value="BLA24_19875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13329">
        <property type="protein sequence ID" value="PPT13329"/>
        <property type="gene ID" value="CYQ11_10915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="147"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="369" mass="38777" checksum="3CFDFD2E8280A1C1" modified="2018-01-31" version="1">MDDDTTGTPRTPLRVGLIGYGLAGSVFHAPLVAATDGLVLDTVVTANPERQQQALAEHPQVRTADTADALLARAGELDLVVIASPNRTHVPLARAALEAGLPVVVDKPLAATAAEAEELAALAEARGLLLSAFQNRRWDNDFRTVRGLVADGTLGRVQRFESRFERWRPHPKGGWRESGDPAEIGGLLYDLGSHLVDQALTLFGPAVTVYAEADVRRPGAEADDDTFIALTHANGVRSHLWMSATTAQLGPRFRVLGDAAGYVKYGLDPQEAALREGLRPGGTQDAWGVEPPASWGRLGAGESPLTGGGEPVPTLPGDYPAYYAAVAEALRTGGRPPVTAAEAAAALRVLEAAKVSAAEGRTVTLKEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD3</accession>
    <name>A0A2G1XFD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20175</name>
        <name evidence="3" type="ORF">CYQ11_10615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49943">
        <property type="protein sequence ID" value="PHQ49943"/>
        <property type="gene ID" value="BLA24_20175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13280">
        <property type="protein sequence ID" value="PPT13280"/>
        <property type="gene ID" value="CYQ11_10615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="194" mass="21166" checksum="B1A6ADC82703173F" modified="2018-01-31" version="1">MRKLTYFISTTLDGCIAGPGGEYDFMYPVLDEDFTAALVASHPDALPGHVRPHLGLGDENRDFDTVIMGRGTYEPGLKAGFTSPYPHMKQYVVSESLAESPDPAVTVFSGDPLELVRELKAQEGKGIYLCGGGNLAGQLREEIDELVVKIYPFVAGDGIRLFSGEFAPERYELKDSHTFKNGAIVARYAKVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFI2</accession>
    <name>A0A2G1XFI2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20320</name>
        <name evidence="4" type="ORF">CYQ11_10465</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49965">
        <property type="protein sequence ID" value="PHQ49965"/>
        <property type="gene ID" value="BLA24_20320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13258">
        <property type="protein sequence ID" value="PPT13258"/>
        <property type="gene ID" value="CYQ11_10465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="297" mass="32522" checksum="3EC8CC99844D80D9" modified="2018-01-31" version="1">MQLQQLRYFATVAEARHFTRAAEALHVAQPSLSQQIRALERELGAELFHRARGNITLTDAGEALLPLAHRILADTETARREVQEVAQLRRGRVRLGAPPSLCASLVPDVLRTFHARYPGIDLHVDEGGSQDLVRTLAVGGLDLALVITPLGVGAPALATTELIHEDLVAVTSPDVPALTRRRRLRVAELRDRPMVMFRRGYDLREITTAACRAAGFDPSFTVEGGEMDAVLGYVRAGLGLAVVPGMVAARSGLRVTPFEDDRMRRTIAVAHRKDTAPPRAARELRRVLLEHLGVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFJ5</accession>
    <name>A0A2G1XFJ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_20545</name>
        <name evidence="8" type="ORF">CYQ11_10235</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50003">
        <property type="protein sequence ID" value="PHQ50003"/>
        <property type="gene ID" value="BLA24_20545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13219">
        <property type="protein sequence ID" value="PPT13219"/>
        <property type="gene ID" value="CYQ11_10235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304853" evidence="5">
        <location>
            <begin position="36"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="82"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="33903" checksum="44478FD268660CEB" modified="2018-01-31" version="1">MGGRSGGAVAAAVRAAPCAVAVVAAAVLWPVPADAGGAHRAAPAAARPPAGPASAACADPEASLRPRTTDGPAVRRIKDRGRLIAGVDQNSYRWGYRDPATRELSGFDIDLVRAVAKAVLGDPDKVTFLAIPTNQRIPALEKGKVDIIARTMTINCDRIKQVAFSTAYFEAGQQVLAPKGSPVTAFDDSLKGKKVCTAKGSTGESELRHESHGASVLTVPNQLDCLVRLQLGQVDAVITDSALAAGQAAQDPSVRLVGKPFTTESYGVAMNLGDEDLVRRVNAVLEDYRRGGDDSPWMLAYRKWLAADLKGITAPPQPKYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFM5</accession>
    <name>A0A2G1XFM5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20750</name>
        <name evidence="4" type="ORF">CYQ11_10030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50040">
        <property type="protein sequence ID" value="PHQ50040"/>
        <property type="gene ID" value="BLA24_20750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13182">
        <property type="protein sequence ID" value="PPT13182"/>
        <property type="gene ID" value="CYQ11_10030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="191" mass="21097" checksum="00B3762C6D60166F" modified="2018-01-31" version="1">MATPPQPQPFSQPQPFQAPQQPGFPQQQQPGFAPQQQGIAQQQGFPPQHGMPPQPGFAQHDSHTYCRICGGFPAVRTTVRGHQGILIMMRFLHLDGPFCRNCGMSVWRDMTGKTMLQGWWSPLSLVLITPLTLLWSLVVRAKLTKLPPPVPGQPGPQLDPGVPLRKRPAMFGLLLPVAWVLFIVFQAARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN7</accession>
    <name>A0A2G1XFN7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">malQ</name>
        <name evidence="9" type="ORF">BLA24_20605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50015">
        <property type="protein sequence ID" value="PHQ50015"/>
        <property type="gene ID" value="BLA24_20605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="703" mass="75663" checksum="9CE7C235161964A5" modified="2018-01-31" version="1">MDRARLAAAHGVATSYESAPGRSVPVPEDTVVAVLAALGVDASTPRAVRDALEARERAERTRLLPPTVVLRPGGERLPALPEGTTLRVDTEDGRALAWDGAAPLPLGGHVLRAHAPDGRSASAPLIVAPGRLPAPPERAHGFLVQLYSLLSARSWGMGDLADLAELAAWSGRAFGSDFVQINPLHAAVPGPPTDPSPYRPSSRRFPDPVHLRVTEVPEFAHLSGEARAEADRLLARAAGLRDAVLRDGALIDRDAVWELKRRALELVRAVPLGPGRRAAYDAFLAERGQALDDHSTWCALAEVHGPDWRAWPGALKDPRSARTARARGELLDRVDFHCWLAWLTDGQLAAAQRAAREAGMRIGLVHDLAVGVHPSGADTWAQQDAFAAGMSVGAPPDAFSPRGQDWGLPPWRPDALAATGHAPYRELLRALFRHAGALRVDHVMGLFRLWWVPQGCEPGRGTYVRYDAEAMLGVLALEAHRAGAVVVGEDLGTVEPGVREALAERGVLGTSVLWFERSYGTGEKGEEGGDEPLPPERWRPGALATATTHDLPSTAARLTGDHVALRHRLGLLTRPLAEEQREDAAAVAQWLALFGRLGLLPEGPGDEEAAVRAVHRFLLLTPARLIGVWLPDAVGDRRPQNLPGTWDQYPNWRLPLADSAGRPLSLEELAASPRLHALMEEVRGPGDADRPPRTRAARGGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFZ9</accession>
    <name>A0A2G1XFZ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21540</name>
        <name evidence="4" type="ORF">CYQ11_09245</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50162">
        <property type="protein sequence ID" value="PHQ50162"/>
        <property type="gene ID" value="BLA24_21540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13054">
        <property type="protein sequence ID" value="PPT13054"/>
        <property type="gene ID" value="CYQ11_09245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304835" evidence="2">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="189" mass="19607" checksum="72FEE4B379478820" modified="2018-01-31" version="1">MSPSRRTRFPALALLLLVPAVLLAACAPGGGTDKVIGGPASAEEPSRILIPAIGVDSPLIRLGKGKDENVQVPPPEKVMTAGWYTGGARPGEPGAAVIVGHHDGRGGKGVFHDLHKVTEGTAIDVRRGDGTVLHFTVTGTETVRRNAFPTRKVYGPTGEKALRLVTCAGELDADGHAAENLVVYAALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG76</accession>
    <name>A0A2G1XG76_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50139">
        <property type="protein sequence ID" value="PHQ50139"/>
        <property type="gene ID" value="BLA24_21380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="170" mass="18218" checksum="648F551F2B18B3D6" modified="2018-01-31" version="1">MASLTRQRFKEHPPHALPPRPLQFVGLTWVDRGPAYWLRRAGTTLFWFLAAAVTGAMAVAVIVTSIPDGTTVLAVALGVYALLCGGAACIVTRHIHTVDRFGTTGAGSREQAGLDGRRSVVARAATALTPVFMVLAIPLALGAVLPFFIRSFGRYSVGERYERRRAGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGB5</accession>
    <name>A0A2G1XGB5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">map</name>
        <name evidence="6" type="ORF">BLA24_22230</name>
        <name evidence="7" type="ORF">CYQ11_08555</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50274">
        <property type="protein sequence ID" value="PHQ50274"/>
        <property type="gene ID" value="BLA24_22230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12940">
        <property type="protein sequence ID" value="PPT12940"/>
        <property type="gene ID" value="CYQ11_08555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="48"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="31091" checksum="2580807372C2F8D0" modified="2018-01-31" version="1">MSGQSLLVPGTLSPARPVPSSIARPEYVGKPAPTPYDGPEVQDAETIERMRIAGGIAARAMAEAAKHIAPGVTTDELDRVAHEYMCDHGAYPSTLGYRGFPKSLCASVNEVICHGIPDSTVLRDGDIVNLDVTAYIGGVHGDNNATYLCGEVDEESRLLVERTREALNRAIKAVKPGRRVNVIGRVIESYAKRFGYGVVRDFTGHGINSSFHSGLIVPHYDSPYHDTLIEPGMTFTIEPMLTLGTHDYDMWEDGWTVVTKDRKRTAQFEHTLVVTDTGAEILTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGF4</accession>
    <name>A0A2G1XGF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_22265</name>
        <name evidence="7" type="ORF">CYQ11_08520</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50281">
        <property type="protein sequence ID" value="PHQ50281"/>
        <property type="gene ID" value="BLA24_22265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12933">
        <property type="protein sequence ID" value="PPT12933"/>
        <property type="gene ID" value="CYQ11_08520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1160" mass="123370" checksum="15274E1032F17C36" modified="2018-01-31" version="1">MRYGILGTTQAFSDDGSPLAVGGVRLRALLAALALHPGRVRGADALIDDVWDGEPPADATGALQALVGRLRRALGHETVASEAGGYRLCAEPDDVDLHRFERLAGEGERALADGDAEKAAVLLDDALALWRGRPLADLPGGAFHAVRHEARHLAARRARLAASVALGQAARSLPELAELSEAHPLDEPLQALHLRALRDSGRPAEALAAYGRVRAVIAGRLGTEPGPELRALHAELLNPEPAGAPAGPGRDTAAPSAPRPGADAPRDTGAEPAAGPTAARAGGADTAAAQAPASSAAPAAAPPRGNLRARLTSFVGREDDLARIRADLAGHRLVTLLGPGGAGKTRLSQEAAESAATAGGHWPDGVWLAELAPVDDPQNVPEAVLTALGARETVVRATAAEGLRAAGDVAGADPLTRLAEHCAPRRMLLVLDNCEHVIDAAARLAETLLAGCPGVTVLATSREPLAVPGELVRPVEPLPDPVALRLLADRGAAARPGFRVDDDPEACAEICRRLDGLPLAIELAAARLRLLTPRGLADRLDDRFRLLTSGSRTVLPRQQTLRAVVDWSWDLLDASERAVLRRLSVFSGGCDLAAAEDVCADGADGAGDVGSWDVAALLGSLVDKSLVVAAPAGDGQMRYRLLETVGEYAGEQLDAAGERAAVERRHLVAYRELARTADPLLRGPEQRVWLDRLELEHDNLRSALRRAVAAGDEQEVLCLVLSLNWFWQLRDHVPDGRAWSKAAAALGPDPFAEPVVPAPPLLGACTDTPPPMTPEVLEEARRQVRLVMLSHLESDMRMVESPEMQRMLHGIVTAYGDGQPQNCRVPGMMWFYARMLTAALDELHRAVDMAVERCRRLGYTWELANALQLRAKLLNDSLDRADQGILDADESLEIFRRLGDSWGVAEALSGRAEAREKRGQFASAAEDYREAIERVRELGSNGQVPLLRSRLVEVLQESGEIDLAEAERMLREALADAERLPPDAAIFPRLQLGVCLGRSGDLRQAREIFEGLLDDFAGRAIALFDGLMNGLGAWVDVLEGRPQEALPKIRVALEMGRHPVSLMVAPQMVAAQLLQGAHAYAVLSCDGAGDGRGAEHARTAAVLLGAYAALRPAGFHASTLEREVREQAETRARALLGRGDFEQACAEGARLSLVEASALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGW0</accession>
    <name>A0A2G1XGW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_16705</name>
        <name evidence="5" type="ORF">CYQ11_16580</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50478">
        <property type="protein sequence ID" value="PHQ50478"/>
        <property type="gene ID" value="BLA24_16705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14267">
        <property type="protein sequence ID" value="PPT14267"/>
        <property type="gene ID" value="CYQ11_16580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7477" checksum="6414457ED2D0D568" modified="2018-01-31" version="1">MPPTVRRLAAQRELGHQPRDASVTRVRNRDAADGRPRGCLRAFGLSRVNLRKQAHAGHLPGVRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX5</accession>
    <name>A0A2G1XGX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type III polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_16725</name>
        <name evidence="7" type="ORF">CYQ11_16560</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50482">
        <property type="protein sequence ID" value="PHQ50482"/>
        <property type="gene ID" value="BLA24_16725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14263">
        <property type="protein sequence ID" value="PPT14263"/>
        <property type="gene ID" value="CYQ11_16560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="5">
        <location>
            <begin position="212"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="369" mass="40232" checksum="E637836DF9BDD5A4" modified="2018-01-31" version="1">MATLCRPAIAVPEHVITREETLDLARTLHADHPQLELALRLIGNTGVQTRHLVQPIEETLKHPGFTVRNARYEREAKARIPEVVLRALDHAGLTARDIDMIVYVSCTGFMMPSMTAWLINTMDFRAETRQLPIAQLGCAAGGAAINRAHDFCQAYPQANVLIVACEFCSLLYQPTDLGVGNLLSNGLFGDALAAAVVRGEGGTGVRIERNGSHLVPDTEAWISYGVRDTGFHFILDKRVPGTMAMLAPAMRDMAEPHDWDVSDLDFYIVHAGGPRILDDLGRYLGLAPETFRYSRATLTERGNIASAVIFDALERLFVDGGAPRDARGVIAGFGPGITAEIALGTWTEEGAEPKDTAERPLRQEARLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX8</accession>
    <name>A0A2G1XGX8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="7" type="ORF">BLA24_16750</name>
        <name evidence="8" type="ORF">CYQ11_16535</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50486">
        <property type="protein sequence ID" value="PHQ50486"/>
        <property type="gene ID" value="BLA24_16750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14259">
        <property type="protein sequence ID" value="PPT14259"/>
        <property type="gene ID" value="CYQ11_16535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Thymidylate_kin" evidence="6">
        <location>
            <begin position="517"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="856"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="519"/>
            <end position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1160" mass="122113" checksum="1449DE7C231BB538" modified="2018-01-31" version="1">MTRAEQPTGQTPTSGALAADSRERAVRALLRFRPLRRLWSAQFAGSTGDALAVLVLMVLALQAAVVSGSFGGGYRGASFAVAAVIGARLLATVLFGAILLDPLSSLFAPAGPLDRRWTMIGADGVRLALLAVAPTWIDWTQPKALAWLLVTAFLIGVAERVWTVAKDGAAPALLPVPPPEGAAVRPLPDHYDALRRLSLRTTFVALPLAAAALVVITLFGNLLGSGIDWFHLHQVALASYLAAGLFAASAAILYLLQLPGLPAGAKAPRMRSPLEGLRRPKAVDGTPDKGRTGAIPVLVLACGAIAAAVAAAVGVAALQAVDLGGGPVGFGLLVLALTGGPVIGIRGARKVLPGFSRRRLLALALALSGLALLAAGLVPDPTTVLLLVLLAGVSAGVVANTGHSLLDQETEEGRRARTTEHLHAVVRLGIAVGAVAAPVLAAAIGPHRLESGSFVFAHGGAAFTLMLVGALLLPVGALVLGRTDDRHGVPFHRDLLDVLRGGDPAEGQSGSGFFIAFEGGDGAGKSTQVRAVAEWIRAKGHEVVVTREPGATAIGKRLRAILLDVSSAGLSDRAEALLYAADRAEHVDSVVRPALERGAIVITDRYIDSSVAYQGAGRDLSPTEIARISRWATDGLVPHLTVLLDVSPETARERFTEAPDRLESEPAEFHQRVRTGFLTLAAADPARYLVVDAGQEPEAITKVVRHRLDQLLPLSAAEIEAREAARKAAEEEARRKAEEEAARKAEEERLERERQEQLAKLRAEEEERKRREAEEARLREEARLAEEARQRAEEARRKAEEERKRREAEERARAAEQERLRKQAEEEARLRAEAEERRLEKQRKAEEALLRAERARLAAEAAAAAEAETSSAAASSAEASGVEPAVASSAPADAPTVETPALGVEETAPTQALRPGSPPAEPVGTPSGQPLPGDEAKAGAEGEAGNDAVGEAKTVEQPRIDADPRTMVMGAVAPGAEDETAVLPPVRPTGPPPGPLDQRVTWGVEPKKPAGPKSAAGASQAAESPRAPKAPRTRKTAETPEAPEAPTAPEAPRTPDASASEETAVLPKPPVRPENPADRVPTWLFRPQDEEAPAGTGAGGEAGADVERTREMPPVDAGPASGQPDRPLRRARRRPEWADDSTLADELLGPREDDEGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH00</accession>
    <name>A0A2G1XH00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16815</name>
        <name evidence="4" type="ORF">CYQ11_16470</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50495">
        <property type="protein sequence ID" value="PHQ50495"/>
        <property type="gene ID" value="BLA24_16815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14250">
        <property type="protein sequence ID" value="PPT14250"/>
        <property type="gene ID" value="CYQ11_16470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="57"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="40764" checksum="14F3B67189A7159B" modified="2018-01-31" version="1">MSAALLDAVRLRLAESGAEPTPARVAEALRREGRLLGDAEVLGVVATLRSELVGTGPLEPLLAEPEVTDVLVTAPDRVWVDRGRGLELTSVTFPDAAAVRRLAQRLAAVAGRRLDDARPWVDARLPDGTRLHAVLPPVAVGSTCLSLRVVRPRAFALDELEAAGTVPPGGQRLLRAVLDARLSFVISGGTGSGKTTLLSSLLGLVAPHERIVLAEDSAELRPDHPHVVRLETRPANQEGTGLVTLRDLVRQALRMRPDRLVVGEVRGPEVTDLLAALNTGHEGGCGTLHANAAPDVPARLEALGSTAGLDRAALHSQLAAALSLVIHLVREPTGRRRIAEVHVLDRDRAGFVTTVPAAVWGPAGFERAPGWERLTTLCERGGSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH36</accession>
    <name>A0A2G1XH36_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">nhaA</name>
        <name evidence="9" type="ORF">BLA24_16855</name>
        <name evidence="10" type="ORF">CYQ11_16430</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50501">
        <property type="protein sequence ID" value="PHQ50501"/>
        <property type="gene ID" value="BLA24_16855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14244">
        <property type="protein sequence ID" value="PPT14244"/>
        <property type="gene ID" value="CYQ11_16430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="465" mass="49215" checksum="26A80DCCBAD488FF" modified="2018-01-31" version="1">MAAPKNRRSVFLGRLPLPERNYLADALRTETVGGVLLLAAAVAALIWANTPLRDSYESVRSFHLGPGSLGLDLSLEHWAADGLLAVFFFVAGIELKRELVAGELRDPKAAILPVVAAVCGMAAPALVYFTTAASGGGSLGGWAVPTATDIAFALAVLAVIGTALPSALRAFLLTLAVVDDLFAILIIAIFFTSKINFAALGFAVVGLAVFWLLLRKGVRGWYFYVPLAVVNWALMYNSGVHATISGVAMGLMLRCTRRDDERQSPGERIEHLVRPLSAGLAVPLFALFSAGVAISGGALSDIFHRPETLGVVLGLVAGKTIGVFGGTWAAARFTRAELNPDLKWPDVLAVATLAGIGFTVSLLIGELAFSDDPVLMGEVKAAVLVGSLIAAVLASTLLKLRDNKYKKLCAEEDRDDDENGIPDIYEQDTPEYHLRMAAKYEAKAAAHRKLAEVAGHGTTDDDGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH37</accession>
    <name>A0A2G1XH37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17160</name>
        <name evidence="8" type="ORF">CYQ11_16115</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50546">
        <property type="protein sequence ID" value="PHQ50546"/>
        <property type="gene ID" value="BLA24_17160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14200">
        <property type="protein sequence ID" value="PPT14200"/>
        <property type="gene ID" value="CYQ11_16115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="115"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SPASM" evidence="6">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="43951" checksum="EAB6585B4AAD8CB5" modified="2018-01-31" version="1">MLPDMLQTSPYLTHVDPGADPPITYWTDTFGPAFPEGDTPAADAAFGIVGLDRRLVWESDREMLAMLRACAAEPQAAEPLVTQYGASRVTAAAARNWLQAPEDLCRAYRLVSGEIEVTAHCNWGCRYCPVATDPKPRRTMPMDLFEEIVAKLTAVGTIDYVTFQFFNEPTLDKHFNDRVTVLAEHGMQLALYSNASALTQDKIDTLKRHDVLRHLIVNMPSADPDEFAQLTGSRSYPHTVRNLRAAIDAGLRTQIVVNGVAEDLARNLDGVTRRYQPLGVEVFPSLTCDRAGDVGGPYAQDVHVEGRLTGCGWPVQHANISVTGDLFLCCNDYYQREVFGNIRDGSIDELMTSDAAVGLRRRVFGVADAPDDFLCRRCHNQAPDFPNRDFRPIATFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHB4</accession>
    <name>A0A2G1XHB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flotillin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Flotillin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_17715</name>
        <name evidence="9" type="ORF">CYQ11_15560</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50634">
        <property type="protein sequence ID" value="PHQ50634"/>
        <property type="gene ID" value="BLA24_17715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14111">
        <property type="protein sequence ID" value="PPT14111"/>
        <property type="gene ID" value="CYQ11_15560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="6">
        <location>
            <begin position="28"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Flot" evidence="7">
        <location>
            <begin position="360"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="545" mass="56016" checksum="5B3F5AD24E735593" modified="2018-01-31" version="1">MVIGIVAGVLLAAVIIVVALFKLMWRVAEPNEALIISGSKHRTDGLEEGMGFRIVTGRGTLVLPGVQAVRKLSLDLNEADLNVDCVTKQGIPLKVHGVVIFKVGDDFVSIANAARRFLDQQKFMGDRVHNVFAGHLRSIVGGLTVEDMIRDRERLTGETRAASGTEMEKLGLIIDSLQIHEIQDPTGYIKNLAAPHAAAVQRDARIAEAEADRLATEAEQQAKARMSQAQRDSEILQAGYQAERDSAAAKARQAGPLAQAAAQQEVVVQETRVAELAARRREQQLQADVRKPADAAAYEKRTLAEAERDARISAAQAKARETELAAAAEATRVKTAAAAEAEATTARGTAAATATRATGEAEAEAARAKGLAAAEASRAQGLAEAEAIKARASALAENQEAVVAQQLAEQWPEIVRAGAQAFGSVDHMVLLNGADGVSDLFAKALTMGGTGLGLARQLLAAMGTADGPGAGTRAGTGPVAGAGGIGAGTGDAGGRDGGGRAGSGGHGRGDGPPAGGPAAGPPRAAPRVERVPVEEDGGIPGAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHE4</accession>
    <name>A0A2G1XHE4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsR</name>
        <name evidence="6" type="ORF">BLA24_17820</name>
        <name evidence="7" type="ORF">CYQ11_15455</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004950692.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50652">
        <property type="protein sequence ID" value="PHQ50652"/>
        <property type="gene ID" value="BLA24_17820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14093">
        <property type="protein sequence ID" value="PPT14093"/>
        <property type="gene ID" value="CYQ11_15455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="78" mass="8945" checksum="D1DED1C1CE0FFA04" modified="2018-01-31" version="1">MAKPPPRKPKKKVCAFCKDKTAYVDYKDTNMLRKFISDRGKIRARRVTGNCTQHQRDVATAVKNSREMALLPYTSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHG7</accession>
    <name>A0A2G1XHG7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase FabG</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17380</name>
        <name evidence="2" type="ORF">CYQ11_15895</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50579">
        <property type="protein sequence ID" value="PHQ50579"/>
        <property type="gene ID" value="BLA24_17380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14166">
        <property type="protein sequence ID" value="PPT14166"/>
        <property type="gene ID" value="CYQ11_15895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="243" mass="24385" checksum="9DD6CB97370A8094" modified="2018-01-31" version="1">MDGKAALVTGGSRGVGAAVALRLAAQGADVAITYVADEAAAREVVRTIEAEGRRGLAVRADAGDAATAAAAVQRTAEAFGRFDVLVNNAGVGVLGPLEQLTLADVDRVLAVNVRGCFLAAQAAVPLMRHGGRIITIGSCMTQRVPGPGGTLYAMSKAALTGLTKALAREVGDRGVTANIVHPGPTDTDMNPAGGPYAAGQSAMTAVGRFGTPEEVASMVAYLASDEARYVTGAEISVDGGHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI64</accession>
    <name>A0A2G1XI64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17430</name>
        <name evidence="3" type="ORF">CYQ11_15845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50881">
        <property type="protein sequence ID" value="PHQ50881"/>
        <property type="gene ID" value="BLA24_17430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16591">
        <property type="protein sequence ID" value="PPT16591"/>
        <property type="gene ID" value="CYQ11_15845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="15927" checksum="460407803F92FC92" modified="2018-01-31" version="1">MQNPAAVIPETMPAILSVMKAAEKGGVPRKTLELVHLRASQINGCGHCVDSGVRSARKGGETDERLFAVAAWREAPYFTDAERAALALAESVTRLSDSADPVPDAVWNEAAQHYDERRLAGLLLWIATSNFFNRLNVPTKQIAGAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI66</accession>
    <name>A0A2G1XI66_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_14185</name>
        <name evidence="6" type="ORF">CYQ11_13890</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50942">
        <property type="protein sequence ID" value="PHQ50942"/>
        <property type="gene ID" value="BLA24_14185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13837">
        <property type="protein sequence ID" value="PPT13837"/>
        <property type="gene ID" value="CYQ11_13890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="205"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="305" mass="33038" checksum="BEEA6FE7EA398F3A" modified="2018-01-31" version="1">MDVLSDAIAAIRTGRPHSSRTVKHAPWGVRFPASDGAGFHVVLQGTAWLLPPDGAEPVRLGAGDVVFLAHGYGHGLADRPDTPLEDARLEPDGSWPTLRHRGPVHGDDTLMLCGAYQLDKARAHPLLTDLPPFVHIPARVGSHDRLRSAIDLLGAELEDPQPGSDAIVPALLDTLLLYLLRTWWLTERPDGPTGWAGALKDPAVTAALQAVHGDPARPWTVEELGARAGLSRAAFARRFTALVGQPPLAYLTWWRMTTAGRLLRTADAPLRTVAEQCGYASEFAFAKAFKREYGVAPGQYRRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIA8</accession>
    <name>A0A2G1XIA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_14420</name>
        <name evidence="8" type="ORF">CYQ11_13655</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50984">
        <property type="protein sequence ID" value="PHQ50984"/>
        <property type="gene ID" value="BLA24_14420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13794">
        <property type="protein sequence ID" value="PPT13794"/>
        <property type="gene ID" value="CYQ11_13655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="29689" checksum="6E4844FE397D470A" modified="2018-01-31" version="1">MSRAEAPAGRAVAGRLGLSLLRSEVGTTFRRWRTLALLGVLAAVPVLVGIAVKVETGDGGTVGSAEGPAFIGQVTNNGLFLVFTSLAATLPFFLPLAVGVVAGDAVAGEAGSGTLRYLLVAPAGRTRLLLAKYVTVVTFCLVATLVVAASALAVGALLFPVGEVTLISGTTVSFGEGLLRALLIAGLVAASLTGLAALGLFVSTLTGSGVAAMATTVGLLIAVQIMDQFPQLDAVRPYLFPHYWLSFADLLRSPVSWDQLLRNLELQGWYVAVFGSAAWAGFTGRDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIH0</accession>
    <name>A0A2G1XIH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-type cytochrome biogenesis protein CcsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ccsB</name>
        <name evidence="8" type="ORF">BLA24_14105</name>
        <name evidence="9" type="ORF">CYQ11_13970</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50929">
        <property type="protein sequence ID" value="PHQ50929"/>
        <property type="gene ID" value="BLA24_14105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13851">
        <property type="protein sequence ID" value="PPT13851"/>
        <property type="gene ID" value="CYQ11_13970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="136"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="38302" checksum="B879C29CDE7542C7" modified="2018-01-31" version="1">MTLAAATNENLAHVSNVLIYSAMAVYTLAFLAHIAEWVFGSRSAVGRTAAALTAEAPARPAVTVKKAGGTAVLERPEVITRAAPGSRDVPDGPGAAGTSEKGDLYGRIAVSLTVLAFALHAGGVLTRALSVQRAPWGNMYEFSTTFGMTAVAVYLGLLAAKKNVRWLGLPLTTSILLDLGLAVSVLYTDSDQLVPALHSYWLWIHVSCAIISGAALWVGATSTLFYLFRDGHEVRLAEGRATGAWDNALSRLPSAATLDKFAYRINATVFPLWTFTIIAGAIWAEAAWGRYWGWDPKEVWSFITWVAYACYLHARATAGWKGRKAAYLALLAFACYLFNYYGVNILLSGKHSYAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIS6</accession>
    <name>A0A2G1XIS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15300</name>
        <name evidence="4" type="ORF">CYQ11_12770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51136">
        <property type="protein sequence ID" value="PHQ51136"/>
        <property type="gene ID" value="BLA24_15300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13642">
        <property type="protein sequence ID" value="PPT13642"/>
        <property type="gene ID" value="CYQ11_12770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304717" evidence="1">
        <location>
            <begin position="32"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="512" mass="53748" checksum="3D7D823ACF5116C9" modified="2018-01-31" version="1">MHRRDVLKMTATAIAGAASVLTLEGVSFARADGSARTAGEETRHVTGRLPAGAPDFVHLPVEVPSGVREIAVSYTYDRPAVPSGTPGNACDIGVFDERGTELGGAGFRGWSGGARTEFAISAERATPGYLPGPVRPGTWHIALGPYTVAPQGMAYDVTVTLRYGAPGLTPAPVYPPRRARGRGRAWYRGDNHLHSVHSDGLRTPAEIAAAARAAGLDWITTTEHNTTSSHAAWQGLWGDDLLILTGEEITTRNGHVLALGTAPGTFLDWRYRARDHAFGRIARTVRRAGGLVVPAHPYGTCVGCNWKFGYEDADVVEVWNGLWTPDDEMAVATWDAMLAAPAREGGAWLPAMGNSDAHREPQVVGLPQTVVLADDLSHDALLAGLRAGRSWIAESSAVALTFGATDGRGGHAGIGERLRVGPDAEVTVRLDVRGAPVTGCTVSFVTDQGVLLTTPVPADGRVEWHTTAARSAYVRAEVRRPPAGGGGDGGGSGLPGAMVALTNPVFLGRAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIV0</accession>
    <name>A0A2G1XIV0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15450</name>
        <name evidence="4" type="ORF">CYQ11_12625</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51157">
        <property type="protein sequence ID" value="PHQ51157"/>
        <property type="gene ID" value="BLA24_15450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13620">
        <property type="protein sequence ID" value="PPT13620"/>
        <property type="gene ID" value="CYQ11_12625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="252" mass="27672" checksum="BE5BFC70411F6513" modified="2018-01-31" version="1">MGSKPWLRRHPAQGPDALARLVCFPHAGGTAATFQGWPARLPPGVETLVVQYPGRQERMAEPCIEDMAETADRVAEELAPHLDLPLTFFGHSMGSGLAYEVARRLERDHAVVVTRVFVSARTAPHHVHGEKRHLLPDEELVASMRALGGPDAEVYDHVQLLPLILPPLRADLRLLDAYRPDRESLPRIQAPVTACGGDSDHTCPTADLSLWQELTTADCEVRVYPGGHHFLRINEADVVGVVSKHLATVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ21</accession>
    <name>A0A2G1XJ21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/galactose cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_15850</name>
        <name evidence="9" type="ORF">CYQ11_12225</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51227">
        <property type="protein sequence ID" value="PHQ51227"/>
        <property type="gene ID" value="BLA24_15850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13549">
        <property type="protein sequence ID" value="PPT13549"/>
        <property type="gene ID" value="CYQ11_12225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="556" mass="58534" checksum="D3AE514FA1655172" modified="2018-01-31" version="1">MRCLAAGLRLPVNALDYTILALYFAVVLGIGVAARRSVRTSLDFFLSGRALPAWITGLAFVAANLGATEILGMAANGAQYGAATVHWYWIGAIPAMVFLGLVMMPFYYGSKVRSVPEFLLHRFGPSSHLLSSVIFAVSSVLIAGVNLYAMALVLQALLGWPQWVAIVVAGLFVLAYITLGGLSSAVYNEVLQFFVILAALIPLTVVGLKRVGGWGGLSDALAARHGDDFLTAWGGTGIGHPNPLGANWLTIALGLGFVMSFGYWTTNFAEVQRALSAKDLSAARRTPLIAAFPKMLIPLVVVLPGLIALVMEPALGAPGGDLSYNDAIPVLMADLLPNGVLGVAVTGLLAAFMAGMAANVSSFNAVFTGDIWAAYARPGRDDAYYLATGRAVTVVGVLAGMGTAFIASSFSNIMNYLQTLFSFFNVPLFVVFVIGMFWKRTTAAAGFWGLLSGTVAAMVNYFALYKRGVIGIPSDQGANFVSAIVAFAVGAVVMVVVSLLTKPRPVEELAGLVYGTRSPGADGPPAEGDDAWYRRPALLGWGALVLASVCYLPFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJA3</accession>
    <name>A0A2G1XJA3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16045</name>
        <name evidence="6" type="ORF">CYQ11_12030</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51261">
        <property type="protein sequence ID" value="PHQ51261"/>
        <property type="gene ID" value="BLA24_16045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13513">
        <property type="protein sequence ID" value="PPT13513"/>
        <property type="gene ID" value="CYQ11_12030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="PKS_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_MT" evidence="4">
        <location>
            <begin position="162"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="446" mass="49262" checksum="C027A8E646E8DC87" modified="2018-01-31" version="1">MAEAARRLTALAEQVLGTPLPVRLRAWDHSESGPPGGPVLVVRRRRALRRLLWRPGELGLARAWVAGDVDVDGDLYEALDLVAGTFWELGERSGRRSRPAALAGALRDPGVRAAAIELLRLSGPWTPPSPPPEEARRTGGPLHTLRRDRQAISHHYDVGNAFYERVLGPSMVYSCAYWPDPGATLEEAQRAKLDLVCRKLALRPGQRLLDVGCGWGSMALHAAREYGVVVVGVTLSREQAAYARKRVAEAGLTDRVEIRVQDYREIPDGPFDAISSIGMAEHVGSARYAEYAADLYGLLVPGGRLLNHQISRRPLDDEATYEVDRFIDRYVFPDGELAPLGRTAAQLEEAGFEVRDVEALREHYALTLRRWVANLEAHWDEAVRLTSPGRARVWRLYMAACALSFERNRIGVNQVLAVRTPESGASGLPLRTRAWLADGRTAAKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJC4</accession>
    <name>A0A2G1XJC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_16425</name>
        <name evidence="8" type="ORF">CYQ11_11650</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51323">
        <property type="protein sequence ID" value="PHQ51323"/>
        <property type="gene ID" value="BLA24_16425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13451">
        <property type="protein sequence ID" value="PPT13451"/>
        <property type="gene ID" value="CYQ11_11650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="33775" checksum="A768789E1195AE1B" modified="2018-01-31" version="1">MSASGGTKAIVAALGANLAIAVAKFVAFAFSGSSSMLAEGVHSVADSGNQALLLLGGKKAKKEATEEHPFGYGRERYVYGFLVSIVLFTIGGVFALYEGYEKIKEPHELEHWYWPVGVLVFAIIAEGFSFRTAIRESNELRGKQTWGSFIRTAKAPELPVVLLEDFGALVGLALALAGVTLTLATGDSVWDGIGTMCIGTLLVLIALVLAAETKSLLLGEAAGPEQVARIRAAAVDGTTVTRVIHMRTLHLGPEELLVAAKIAVPGGDTAAQVARAIDEAEVRIREAVPIARVIYLEPDIYSEEAAAAGLDPKATPGGPGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJH0</accession>
    <name>A0A2G1XJH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15245</name>
        <name evidence="3" type="ORF">CYQ11_12825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51350">
        <property type="protein sequence ID" value="PHQ51350"/>
        <property type="gene ID" value="BLA24_15245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16526">
        <property type="protein sequence ID" value="PPT16526"/>
        <property type="gene ID" value="CYQ11_12825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="376" mass="41875" checksum="503AB9EFD19FAFED" modified="2018-01-31" version="1">MEFGIFVQGYVPASRSRTDPAAEHHALMEEAEYVVQADRSGFKYAWVTEHHFLEEYSHLSANDVFLGYLAHATDHIHLGSGIFNPLPQVNHPVKVAEKAAMLDHLSGGRFEFGTGRGAGSHEILAFLPGTTDMNATREIWEETIAEFPKMWCQEEYEGFRGKHWSLPPRKVLPKPYGPSHPAMWYAAGSPSSYAMAARKGLGVLGFSVQKVSDMEWVLDSYKSVIGEAEPVGGFVNDNVMVTSTAICAETHQKAVEIAASGGLNRLQSLLFRYHDTFPRPEGIPEWPELLPEYTEDIIELLIAEELMICGDPDEVLRQCERWERAGADQLVFGLPVGIPYEDTITTLQLIGEHVIPKIDTDPVHRTTRFRRAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJH5</accession>
    <name>A0A2G1XJH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14215</name>
        <name evidence="4" type="ORF">CYQ11_13860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51331">
        <property type="protein sequence ID" value="PHQ51331"/>
        <property type="gene ID" value="BLA24_14215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16545">
        <property type="protein sequence ID" value="PPT16545"/>
        <property type="gene ID" value="CYQ11_13860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="359" mass="38958" checksum="9AF8903B2C15CC7B" modified="2018-01-31" version="1">MYQSQNRRQSRRGKRWLIVVATIAVLGLIAAGVLNYFKIGPFSDKGKPVSFGQDKDGGQAGGANAQKPDSKVSMPTGPKAEFKNTSTLSDGTQVAVTTLDGKKSGFKGKVWVWAPKAYSDPKFKDHGFPVLVALPGGPGFPNNYWMDDGGLHLESSITKWYNEGKGKPFILAMPVLNPKPDDGGLYWDGSDIPGQPKMGTWLTEDVPDLMKANFRTIKSRDGWAFMGSSSGAFSGLKAVLKHPDKFKAVIASGPDIVPDSPLWKGHEKEKAENNPEVLAKDLIARKGPDVYLAFQYGTKESSVIPHVDKFIATYGNKGPVHTRLQKIEGGKHNAKTYIEGMDAGSMQWISEHMAGPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJM4</accession>
    <name>A0A2G1XJM4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_13975</name>
        <name evidence="12" type="ORF">CYQ11_01670</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51435">
        <property type="protein sequence ID" value="PHQ51435"/>
        <property type="gene ID" value="BLA24_13975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11776">
        <property type="protein sequence ID" value="PPT11776"/>
        <property type="gene ID" value="CYQ11_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT11776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="235" mass="25117" checksum="C16ADD56447B7452" modified="2018-01-31" version="1">MDRQELRKRFAALTTAHVADACVRAGAEVRCAPPSVRTAVPGGRLAGRVAPARHTGSVDVFLEAFESTAPGDVLVVDNGGRLDEACVGDLAALEAQAAGLEGIVVWGLHRDTAEIRAIGLPVFSMGATPPGPRRLDERPHDALTAATVGDWTVGRDDVVLADDDGVLFVPLGQVGELFDLAETIRDTEHRQAERIRAGVSLREQVRFGTYLADRRRTPSLTFRAHLRSVGGAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJY1</accession>
    <name>A0A2G1XJY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_13460</name>
        <name evidence="5" type="ORF">CYQ11_01180</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51510">
        <property type="protein sequence ID" value="PHQ51510"/>
        <property type="gene ID" value="BLA24_13460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11692">
        <property type="protein sequence ID" value="PPT11692"/>
        <property type="gene ID" value="CYQ11_01180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="408" mass="45078" checksum="F0DE6D06D8716C91" modified="2018-01-31" version="1">MTAPHAPASEEAPHDQPLPHYPFSTRGDRLAPELGELRSRCPVARVSTNSGDQAWLVTGYELTQHVLRDRSFARSVLAEADSPGQDAPILAPELLDAMNHLQKAGLREEVLKALGRDQPELPADWVAAVTGEGLDAMVREGGPGDLQHHFAEWVAAQCMCRLLGLPFEDREWLAVRADLDLTMVTPTHEELARNWEEIRVYMDEHMAARRPGEPRGLADRLADLNAAHQGLTDQQLSNIVSVLFVSGYEDFASFLGVAAFNLLQHPEVMSAVRARPETMPQCVEELLRCSVVLGNAIPRFVTKETELGSAQVKEGDMILLSLDAVNYDSAAFSDPETFDPARSPNPHLRFGYGRHHCPGAHLVRRQSDVAFRVLLDRLPGIRLAVPPAEVPWHPNRMAIMPAGIPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK05</accession>
    <name>A0A2G1XK05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12860</name>
        <name evidence="5" type="ORF">CYQ11_17215</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51584">
        <property type="protein sequence ID" value="PHQ51584"/>
        <property type="gene ID" value="BLA24_12860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14376">
        <property type="protein sequence ID" value="PPT14376"/>
        <property type="gene ID" value="CYQ11_17215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758496" evidence="2">
        <location>
            <begin position="27"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="64"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="348" mass="37331" checksum="C0AC2D0A50944333" modified="2018-01-31" version="1">MRTSRIALALLAAVTLTSCGAKVSDAPDDKQGGGQGGTQQAGGHYPVTVENCGVKKTFDKAPRRVVTNDVNMAEIMFALGLEDHMAGYVAPDYRTSRDDKGEAPWKSGYDKVKWLSKKEINKELVLEAKADLVFAGWNYGFGEGAGFTPDALKKVGVDSYVLTESCRNGATGGSRGVMPPLEALYTDLENLGKVFDAEDRARELVAGFKKQVADARARVPGGGRAPRVFLYDDGRDKPLTSGAYAGPHDIITKAGGDHVMKDLKDSWVPVGWETVVARDPEVIVINNYGDVSAAEKKKFLMSYPPLAGVSAVKNDRVFVLDYVDLVESPRNPAAVAALAGYLNGVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK74</accession>
    <name>A0A2G1XK74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12475</name>
        <name evidence="2" type="ORF">BLA24_28120</name>
        <name evidence="4" type="ORF">CYQ11_17560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000157">
        <property type="protein sequence ID" value="PHQ48753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48753">
        <property type="protein sequence ID" value="PHQ48753"/>
        <property type="gene ID" value="BLA24_28120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51643">
        <property type="protein sequence ID" value="PHQ51643"/>
        <property type="gene ID" value="BLA24_12475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14433">
        <property type="protein sequence ID" value="PPT14433"/>
        <property type="gene ID" value="CYQ11_17560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="15375" checksum="B9B2C7F37984C075" modified="2018-01-31" version="1">MDTPPTSATLPDTPQKRHLPLGAGIAALLVPVVTALGVISSLYVQVIHEDWVDRQQAACRIMARPQMEFVVAWGGPALGVAAVILCVLLARRTRRRHGVRLGETWPGLIAYLSVGANALAILLELFMLYAAFSSDGSGSVLGDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKG8</accession>
    <name>A0A2G1XKG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_11500</name>
        <name evidence="8" type="ORF">CYQ11_02735</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51710">
        <property type="protein sequence ID" value="PHQ51710"/>
        <property type="gene ID" value="BLA24_11500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11959">
        <property type="protein sequence ID" value="PPT11959"/>
        <property type="gene ID" value="CYQ11_02735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="199"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="388"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="608" mass="65819" checksum="F0DBAACD7E1082E0" modified="2018-01-31" version="1">MTDQVSDYILARLREWGVERVFGYPGDGINGLLAAWARAGDQPRFIQARHEEMAAFEAVGYAKFSGRLGVCAATSGPGAIHLLNGLYDAKLDHVPVLAIVGQTARSAMGGSYQQEVDLHSLFKDVASDFVETVTVPEQLPNVLDRAVRTAYARRAPTAVIVHADVQELDYTPPTHAFKMVPSSLDRSGWQAVPSDDALSRAAEILNAGEKVAILAGQGAAGARHEVEQVAEILGAGVAKALLGMDVLSDELPYVTGSIGLLGTRPSYEMMRDCDTLLTIGSNFPYSQFLPDFGKARAVQIEIDPHRAGLRYPYEVNLIGDARATLLRLVPLLERKDKRGWQSRIIAGVEQWEEMLQRRAEVSADPVNPELVARALSPLLPDDTILTSDSGSVANWYARHIRMRGTMRGSLSGTLATMGAGVPYAIGAKFAHPNRPVVALVGDGAMQMNGMAELITVAKYQHQWEDPRLVVGVWNNRDLNQVTWEMRAMSGSPQFLPSQELPDVSYAEFARSLGLTGVRVEKPDDVVDAWREALAAKGPAVVEFVTDPAVPPIPPHADWDQIEATAAAIVKGDTDRKAMIRQGFKAKIQEFLPGGHKKPGAGPSEGQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKH2</accession>
    <name>A0A2G1XKH2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11625</name>
        <name evidence="4" type="ORF">CYQ11_02865</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51732">
        <property type="protein sequence ID" value="PHQ51732"/>
        <property type="gene ID" value="BLA24_11625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11980">
        <property type="protein sequence ID" value="PPT11980"/>
        <property type="gene ID" value="CYQ11_02865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="60"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="18753" checksum="CAD39BF5929D4EEE" modified="2018-01-31" version="1">MGRVRRVLGRPIVIGLLAVGIMAGAAGLYWFQPWKLWVDDTVREAAPAAAAGDARGGGPRTLATGKLISHEHETSGSVRILELPDGTRTLRLENLDTSNGPDLRVLVSDAPVKEGRAGWYVFDDGAHVSLGKLKGNKGDQNYALPADLDLGRYRSVSIWCDRFDVSFGAAALSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL80</accession>
    <name>A0A2G1XL80_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000106">
        <property type="protein sequence ID" value="PHQ52014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52014">
        <property type="protein sequence ID" value="PHQ52014"/>
        <property type="gene ID" value="BLA24_10120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="243" mass="25864" checksum="B18B80822D9A1816" modified="2018-01-31" version="1">MLIVLDNAAGAEQVRLLLPGGSRSAVLITARALASMPATLRLPLEGLSGTDAFTLLSRLAGPGRMEREPQSAAALATTCGRLPLALRVTAARLAARPSWSVAEMVTRLSDEVRLLRELRVQDLSVEAAFELSFAQLDPEQSRAFMMLSLPHSLDWCVPSAAAVLCLPELETETVLESLVDAALLETPAPGRFRYHDLVGVYARAKACAGLPRASASTPSSGRSTTRRPASSAPCGPPIRWAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLH9</accession>
    <name>A0A2G1XLH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF4352 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09225</name>
        <name evidence="6" type="ORF">CYQ11_27835</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52095">
        <property type="protein sequence ID" value="PHQ52095"/>
        <property type="gene ID" value="BLA24_09225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16175">
        <property type="protein sequence ID" value="PPT16175"/>
        <property type="gene ID" value="CYQ11_27835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304779" evidence="3">
        <location>
            <begin position="34"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="100"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="209" mass="21464" checksum="B81F5E5E32EFB41C" modified="2018-01-31" version="1">MNTSKATPHGGTILRRQLATAAVVLTLAVTATACNDGDGTDNNSPDPAATAAQSPASQGQGKDKPAPGGDRNVTVGGTITVTAKNGAKVAVTLKNWVDPAKSNNKFMTPKPGKRWVAAQLEISNTGQSVYDDSPANGVKVLDEGTEPWTHSIGETTSGPNMPATVKLKPGEKALGYVVVSVPEQSKPKAVTFAPDSGFSSDIAQWAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLU8</accession>
    <name>A0A2G1XLU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08765</name>
        <name evidence="2" type="ORF">CYQ11_04025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52244">
        <property type="protein sequence ID" value="PHQ52244"/>
        <property type="gene ID" value="BLA24_08765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12177">
        <property type="protein sequence ID" value="PPT12177"/>
        <property type="gene ID" value="CYQ11_04025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="32241" checksum="32A3C6C63B5DC09E" modified="2018-01-31" version="1">MPASSDRQVVEVEGHRLSLSHLDRVLFPESGYTKAQVLRYYARVAPVMVPHVQGRPASFVRAPEGPRGESWVAKNPPPGSPTWVSVVPVKHREGTTQQIVVDSTAALVAMANLGAYEVHVPQWKADAGPGAHDRLVLDLDPGPGTDLVVCARVAQRLRQLLDDDGLTAHPVVSGSKGLHLYAPVHPASGRAVSGYAKELAARMMGEHPGLVVVSMARIERRGKVLIDWSQNASAKTTAAPYTVRLRETPGVAAPVTWDEVAACREPGQLAFDPEQVLDRVAEYGDLLAPLTTDATRGHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM20</accession>
    <name>A0A2G1XM20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000091">
        <property type="protein sequence ID" value="PHQ52292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52292">
        <property type="protein sequence ID" value="PHQ52292"/>
        <property type="gene ID" value="BLA24_08395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="65" mass="6592" checksum="F932642934545053" modified="2018-01-31" version="1">MRVLLRLGHDHFTTAVPSSDGRFATGTNVSTTADTQVSCGAGDGNYTLVPLLSGVKALNLASGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM64</accession>
    <name>A0A2G1XM64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07645</name>
        <name evidence="4" type="ORF">CYQ11_00075</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52327">
        <property type="protein sequence ID" value="PHQ52327"/>
        <property type="gene ID" value="BLA24_07645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11530">
        <property type="protein sequence ID" value="PPT11530"/>
        <property type="gene ID" value="CYQ11_00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015378">
        <property type="entry name" value="Transposase-like_Mu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009004">
        <property type="entry name" value="Transposase_Mu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09299">
        <property type="entry name" value="Mu-transpos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="145"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="543" mass="59619" checksum="D93F97FC13E72882" modified="2018-01-31" version="1">MPAVSVRALRGPAVRRLLVLRREGKLTTGRVRSAADVLGVRERAVWRWLAAAERDEAAARAPGERAAYSGRFTVTDEVRALLGLWKGNVAAVHRELAARAARGEGDPPPSIPTLHRAIRRDLSPGERAGLVGGERAARKHDVFLARSRGWRNKVWETDHMQVPVLVDVDGKPRRPWITWFTDCATNAITGVAVTPVHPSRESVLAALRSAVLREDPYGPFGGLPEKVQVDRGKDFLSRTVTAAFDLLDVTVEDLPAYTPHLKGTVEGLNRTVESMFLAALPGYARQPRPGKRPSRPKDEVLLSFEDFTARLLAWTRWWNTEHRPAPLRGRTPLEAWQDDPTPLRDVSAADLWTFTLEDAGSRTLTTRGIRFKKRDYVGAWMTGQAGIQVRVRFMPHHDHRIEVYHAATGRYLGPADLADQATEEQVSAVRRARAARSRRLKKDLEASQRERYAAVTQAEAPQRLGALTTAQAEAELAQAAGTDLSALAMPDLIPPAAPPADWRTPPSLVTRTAPGRPAPVPSEPAPGRVPGSTAQTTEDGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMG1</accession>
    <name>A0A2G1XMG1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07595</name>
        <name evidence="4" type="ORF">CYQ11_00025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52406">
        <property type="protein sequence ID" value="PHQ52406"/>
        <property type="gene ID" value="BLA24_07595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16251">
        <property type="protein sequence ID" value="PPT16251"/>
        <property type="gene ID" value="CYQ11_00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015378">
        <property type="entry name" value="Transposase-like_Mu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09299">
        <property type="entry name" value="Mu-transpos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="252"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="707" mass="78278" checksum="68DF1DEA398EAE28" modified="2018-01-31" version="1">MVEVGAHVAYRGQTWQVAALQGQQVYLLQGGGIETRLLLGRLFADPGFEVVGARAPAAVPQWGLFETVPVAAQQRALAWLPHIREVETGWPHPEGGRDGQTMRPEYDPDRWTLAQRDAAKAQELAALGFARVTRTTVQRMRHVYRKQGLWGLVDKRAVPARGRHPTGYADERVVAAVLEAMRRQRGRSKGTVKGLQVLVGQILEDTHGRGVVEMPSRSTFYRLVSVLADPADRPGRPARTATAPARASSAPVVLRPGEQVQIDTTRLDIMAVLEDGSLGRPELTIAVDVATRSILAAVLRPHSTKAVDAALLLAEMAVPHPARPTWPQSLHLSRAEVPYERMLSLDERLEGAAARPVVVPETIVVDRGKIYLSQGFVAACETLGVSVQPAPPRRPQAKAVVERTFGAINDLFCQHVAGHTGSNPQRRGVATEAEARWTIPQLQDFLDEWITCGWQNRPHDGLRHPVLPKTVLTPNQMWAALITISGYVPVPLTGADYLELLPVRWQPITERGIRLDYRTYNHDILDPHRGQRSPVASKDGKWEVHHNPHDARQIFVRLTDGQLHEIPWIHRDHVHQPFNDALWRHIQTEVEQRGDRETHEADLADALDQLLRRTRSTAGMEHEASPRKRSRARGADVRLPDLPGQRRPLEAENAPAPEPDWSESLDDLIGTDPVTEPGTGDLDGTSAAPAEAGGYGLWDAEAEAEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMG3</accession>
    <name>A0A2G1XMG3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lant_dehydr_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06560</name>
        <name evidence="3" type="ORF">CYQ11_26710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52442">
        <property type="protein sequence ID" value="PHQ52442"/>
        <property type="gene ID" value="BLA24_06560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15974">
        <property type="protein sequence ID" value="PPT15974"/>
        <property type="gene ID" value="CYQ11_26710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="35135" checksum="54065772D08B51E8" modified="2018-01-31" version="1">MDMTTTAPDARTEAAGDRWTAWHLHLATHRPEHHDRLIHEVVAPVVADGGHQWFHIRYWNRGPHVRLRVADLGPGEADALERDLGRRLAAFLPGCPREVDAAAYAESSRHAAAFDRTDTASPGAFREPGVHRDRYVPETVRYGGAALLPLSHELFHRASRVALAAWPPPAGGGSRLTTGLQAMTAGLAALGGPEAVSRYLDRSLVMMTELHRASPVPVDRLVAAAERQAAAPAAAGIARALAAGRYAQVWEPWAGRLGEALAVWRAHGGGVVPPEAILASHLHMMANRLGVTPHQELQLVALLRSVLTRRQDAAVRHSTKGQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XML1</accession>
    <name>A0A2G1XML1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07705</name>
        <name evidence="2" type="ORF">CYQ11_00135</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52411">
        <property type="protein sequence ID" value="PHQ52411"/>
        <property type="gene ID" value="BLA24_07705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16255">
        <property type="protein sequence ID" value="PPT16255"/>
        <property type="gene ID" value="CYQ11_00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046275">
        <property type="entry name" value="DUF6308"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19827">
        <property type="entry name" value="DUF6308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="231" mass="24558" checksum="730F41F798C11854" modified="2018-01-31" version="1">MSVPHATSGVCGGALSPLGQRLRVLLSSERVVGDLRRYFGIGMPPGAVAFTGSRFEYLAGGGGRPEFADRITGEGMVAVQTLSVTVPAPVALDILEGRLGVRMSGLLEGIPRDIDMADAEVSVLADGSPAGQAWSLLCEQYGVNWVIAGKVLARKRPRLLPVYDRSVRCAVGRPPSFWLALHAALREDDATLHRQLLELRQAAGLPGTVSALRVCDVAVWMSHRALGHACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XML4</accession>
    <name>A0A2G1XML4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06825</name>
        <name evidence="2" type="ORF">CYQ11_26975</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52487">
        <property type="protein sequence ID" value="PHQ52487"/>
        <property type="gene ID" value="BLA24_06825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16020">
        <property type="protein sequence ID" value="PPT16020"/>
        <property type="gene ID" value="CYQ11_26975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="6940" checksum="B2139D7B6650EA19" modified="2018-01-31" version="1">MSDTDADPLRRIAATIDREREPSSRVCLSCGGPALVVVTEEPAGNSPPVISVRKECAHRRCEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR5</accession>
    <name>A0A2G1XMR5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07120</name>
        <name evidence="4" type="ORF">CYQ11_27275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52537">
        <property type="protein sequence ID" value="PHQ52537"/>
        <property type="gene ID" value="BLA24_07120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16075">
        <property type="protein sequence ID" value="PPT16075"/>
        <property type="gene ID" value="CYQ11_27275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304921" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="77"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="530" mass="56697" checksum="52061B2791DDCA3F" modified="2018-01-31" version="1">MTARSIRGVAATAMAGVLAAGAVACAAPGGGREGGAGDSLVVGLANEPETLSPLLGYGKDGNSKIFDGLLRRDAGMKLRPALAAELPKVTDDGRTYTYKLRQGVKFSDGEPFTARDVVFTYRTILDEKTNNAAKGELDAIDEVTAQGDDTVVFALKYPYAPFAERTVLPIAPEHAAKGQDVNTGSFNTAPIGTGPYVLTGWSKGEKLTFKANPGYWGGEPKVKKLTMAIIKDDDVRATRLRSGDLDGAVLPPNLVKGFKGDKDKVTLTARTTDFRGVTLPTAGKVTGDPAVRRALDLAVDRAAMVDKLLEGAGRAGYGPVPTDSEWFAEGTERPHDLEKAQRLLDDAGWRPAAGGVREKDGQRASFTLWFPAGDKLREEHALAFASDAKKAGIEVKVQSGTWEVIEPRMKDDAVLAGGGNPADPDFDLYNLLHSSLALDGFNNMAAYASPDVDKALEEGRRSGDKSARKAAYDKVQQGLADNPGYVFLTDVDHLYVVNDAWQDLTTQVEPHDHGLGAGPWWNVEDWQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMZ2</accession>
    <name>A0A2G1XMZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_07465</name>
        <name evidence="5" type="ORF">CYQ11_27615</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52598">
        <property type="protein sequence ID" value="PHQ52598"/>
        <property type="gene ID" value="BLA24_07465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16135">
        <property type="protein sequence ID" value="PPT16135"/>
        <property type="gene ID" value="CYQ11_27615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304735" evidence="2">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="17285" checksum="7C73306D5A3573F8" modified="2018-01-31" version="1">MTATASAPSAPLAPAAPSPVLAVPPAAPEAAAAYFAARLAFHTDVADVHAALAAGTADFVVVDSRSTASWDQGHIPGAVHLPTAQIPELAARVLDPAVPVVVHCWGPGCDGATRAALALARLGYRVKEMLGGIEYWIREGYAVETWEGRRQSPPDPLTAPVDADDCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN17</accession>
    <name>A0A2G1XN17_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07490</name>
        <name evidence="3" type="ORF">CYQ11_27640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52603">
        <property type="protein sequence ID" value="PHQ52603"/>
        <property type="gene ID" value="BLA24_07490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16140">
        <property type="protein sequence ID" value="PPT16140"/>
        <property type="gene ID" value="CYQ11_27640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="276" mass="29355" checksum="A78297E2C894C6E4" modified="2018-01-31" version="1">MTEKISFAVDTPSGQRTTEVHYERLGDGEPLVLLHGIGHHLQAWDPVVGVLAAERDVIAVDLPGFGASPALPDGVAYDLRGVTPVLRAFFEALGLDRPHVAGNSLGGILALALGHEKLVRSVTALSPGGFWTEAERRWAFGMLTGMRQGALRLPERAVAALARTAAGRAALVSTIYTRPGRRSPDAVVAETRALREATGFEATLAAGRAVRFTHDVPDMPVTIAWGTGDRLLLPRQGVRAKKVIPGARLVRLPGCGHVPMSDDPALVARVILDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNG1</accession>
    <name>A0A2G1XNG1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05645</name>
        <name evidence="3" type="ORF">CYQ11_02105</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52750">
        <property type="protein sequence ID" value="PHQ52750"/>
        <property type="gene ID" value="BLA24_05645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11848">
        <property type="protein sequence ID" value="PPT11848"/>
        <property type="gene ID" value="CYQ11_02105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="92" mass="9556" checksum="AB83C6DF97CE6A3B" modified="2018-01-31" version="1">MKEHEPECCSREVTAGPGGAMTDEVGVVTGDLTLKVMRRPDGLTDVRVQYTGAEEWYTLTGGPVRVPPGGLEGLCEATAAAVRAGGAAEVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNP3</accession>
    <name>A0A2G1XNP3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04600</name>
        <name evidence="4" type="ORF">CYQ11_28930</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52857">
        <property type="protein sequence ID" value="PHQ52857"/>
        <property type="gene ID" value="BLA24_04600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11487">
        <property type="protein sequence ID" value="PPT11487"/>
        <property type="gene ID" value="CYQ11_28930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758523" evidence="2">
        <location>
            <begin position="30"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="42907" checksum="51D1A88EAE9262BF" modified="2018-01-31" version="1">MPRPRLTGRLFTAVLSLTLLTAATAPATAAQGPPRAGRDPAGRCALPGRTGYTDEGHDTDPVQFRRPLGTLRLAMVFVDFPDAPATGPTGDVAAQLLPGANWLRDASYGKVRLAVTPARSWVRMPKPSTAYGFERGLSHEQHERYVRDAVTAADPYTDFSRYDMVYVVPPRNAPAISFSPAYLFDPAASGVVADGTRIKWAVTFGQDMWRWGPRLVGHETAHLFGLPDLYAFDGSDVHRYVGGWDVMGLVSGAAPHYSGWHAWKLGWLDDDQVACRATPGTDTVRLTPVEYRGGGTKAAVVRTSPTTAYVVESRRAVAADARACSTGVLVYRVDSATPTGHGPVRVQDARPDATPPAGCGQLDDAAYRAGQSFTDPASGVRVDVLDSRDGSDTVRITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP05</accession>
    <name>A0A2G1XP05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sirohydrochlorin chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04695</name>
        <name evidence="4" type="ORF">CYQ11_28835</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52968">
        <property type="protein sequence ID" value="PHQ52968"/>
        <property type="gene ID" value="BLA24_04695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11518">
        <property type="protein sequence ID" value="PPT11518"/>
        <property type="gene ID" value="CYQ11_28835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="21928" checksum="B402E4901D481AD3" modified="2018-01-31" version="1">MARVRSLRPCLEVRCGFLGLAAPGLAEVLARTAGRAVVVPLLLGTGYHVRVDIPAAVGAAGHLRTRTAGPLGPHPLLAEALGDRLGEAGWTGAPGGAVVLAAAGSRDPAAGAATGRMARMLAARLGAPVEPAFVGGASPTPAAAVAALRARGHGRVAVVPYLLAPGDFARRAAQPCGADVVGAPLGPHDAVARLVLRRYDEEAARVPVPECVAAGAGGGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPU1</accession>
    <name>A0A2G1XPU1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ORF">BLA24_02795</name>
        <name evidence="10" type="ORF">CYQ11_05090</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53258">
        <property type="protein sequence ID" value="PHQ53258"/>
        <property type="gene ID" value="BLA24_02795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12351">
        <property type="protein sequence ID" value="PPT12351"/>
        <property type="gene ID" value="CYQ11_05090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="546" mass="59649" checksum="2A3C4FE6070286BF" modified="2018-01-31" version="1">MTEYGRGSGSQPWHPEDPLYGDRGYDGQQYAQPQPPYGQQQHYPEQQQYGWDPSHTAGGQYAGNAGDPYAAQHTGGYGDGQQDPYGAPGGYPQAEHPQAQHPQSPQHPQAQQQTPYVGEQRQGQHEQLRQPQAPAGPAGDEWRTEPDEEKLSFFDDDPADHGPDAEDDAEAADEPRGRGRERRGKGKGKKNKRRSGTACLLVAVVLVGVVGGGGYLAYDYWQSHFGPAPDYEGEGDGQVQVEIPKGSSLTQMGQALEKAGVVKSVGAFTEAAAKKSIQPGTYTLRKEMSGAAAVAMMTDSGNFLTLREGIRAADVYAAIDKKLELKAGTTKEVAKSQVKNLGLPDWAGGDPNLKDPLEGFLFPSQYSAGKGTKPEDILRQMVARAKKNYDEQDLAGKAKDLGLKSPLQVITVASLVQVEGKYKHDFDKISRVIYNRLKPDNKETYGLLDFDSTVNYARSQSTLDTGAVSDLRKFKDPYNTYNVKGLPPGPISNPGMDALKSALEPTPGPWYYFVSVNENETLFAVTNEEHNKNRQRYEQEHKKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPU5</accession>
    <name>A0A2G1XPU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02845</name>
        <name evidence="3" type="ORF">CYQ11_05140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53267">
        <property type="protein sequence ID" value="PHQ53267"/>
        <property type="gene ID" value="BLA24_02845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12361">
        <property type="protein sequence ID" value="PPT12361"/>
        <property type="gene ID" value="CYQ11_05140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="24707" checksum="0EAA2D3AEB3677ED" modified="2018-01-31" version="1">MLIAGFPAGAWGTNCYLVAPAAGEECVIIDPGHQAAQGVEEALKKHRLKPVAVVLTHGHIDHVASVVPVCGAHDVPAWIHPADRYMMSDPGKALGRSIGQQLMGELTVGEPDDVRELSDGSRLDLAGLEFTVAHAPGHTKGSVTFRMPESSDVPSVFFSGDLLFAGSIGRTDLPGGDHSEMLQSLARVCLPLDDSTVVLSGHGPQTTIGHERATNPFLREVAAGPGAGHPAPRRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ28</accession>
    <name>A0A2G1XQ28_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02745</name>
        <name evidence="3" type="ORF">CYQ11_05040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004948690.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53249">
        <property type="protein sequence ID" value="PHQ53249"/>
        <property type="gene ID" value="BLA24_02745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12342">
        <property type="protein sequence ID" value="PPT12342"/>
        <property type="gene ID" value="CYQ11_05040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16837">
        <property type="entry name" value="BldD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038099">
        <property type="entry name" value="BldD-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037664">
        <property type="entry name" value="BldD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="166" mass="18143" checksum="E05F4345811F73BD" modified="2018-01-31" version="1">MSSEYAKQLGAKLRAIRTQQGLSLHGVEEKSQGRWKAVVVGSYERGDRAVTVQRLAELADFYGVPVQELLPGTTPGGAAEPPPKLVLDLERLAHVPAEKAGPLQRYAATIQSQRGDYNGKVLSIRQDDLRTLAVIYDQSPSVLTEQLISWGVLDADARRAVQHEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQE9</accession>
    <name>A0A2G1XQE9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2252 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00590</name>
        <name evidence="2" type="ORF">CYQ11_07600</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53464">
        <property type="protein sequence ID" value="PHQ53464"/>
        <property type="gene ID" value="BLA24_00590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12769">
        <property type="protein sequence ID" value="PPT12769"/>
        <property type="gene ID" value="CYQ11_07600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="441" mass="48497" checksum="CC4A6D290D6B7521" modified="2018-01-31" version="1">MALEHDRSAQRGEEILAVFDTAFGELLAADPAAFRVKFRKMAASAFAFYRGTACLFYADLQHERDAGPYLDERTGRVWIHGDLHAENFGTYMDANGRLVFNVNDFDEAYVGPFTWDLKRFAASVALIGYTKALSDEKITELVRTYAAAYRERIHALATGAQDDDLPPFTLDTADGPLLDALREARAQTRFGLLATMTEIRDFERRFLEDGGAVELDAATRYKILAAFDGYLETLPDTSLTRPDSYRVKDVVGRRGVGIGSAGLPSYNILLEGNSDALENDVVIYMKQGQTPAVSRHITDPAVRGYFQHEGHRTVISQRALQAHADPWLGWTELDGAGQLVAEVSPYAVDLDWSDIDDPAQIAAVVADLGRATATMHAAADDQSGHSLVPFSTERAIDAVIAADEEGFADLLVDFAHTYGARARADHQIFVDLFRNGRIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQM2</accession>
    <name>A0A2G1XQM2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00970</name>
        <name evidence="3" type="ORF">CYQ11_07980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53534">
        <property type="protein sequence ID" value="PHQ53534"/>
        <property type="gene ID" value="BLA24_00970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12839">
        <property type="protein sequence ID" value="PPT12839"/>
        <property type="gene ID" value="CYQ11_07980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="27664" checksum="A40DF992186064E9" modified="2018-01-31" version="1">MRVHVVSDVHGNAEGLARAGEGADALVCLGDLVLFLDYADHSRGIFPELFGVEAADRIVELRTARRFEEARALSRGLWAGIDRESAVEQAVRKQYAELFAAFPTPTYATYGNVDVPPLWPEYARPGTTVLDGERVEIGGLVFGFVGGGLISPMRTPYEIPEEAYAAKLAALGDVDVLCSHIPPDVPELCYDTVARRFERGSSALLETIRAVRPAYALFGHVHQPLARRMRIGATECVNVGHFASTATPWVLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQP6</accession>
    <name>A0A2G1XQP6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Export ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00605</name>
        <name evidence="6" type="ORF">CYQ11_07615</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53565">
        <property type="protein sequence ID" value="PHQ53565"/>
        <property type="gene ID" value="BLA24_00605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16414">
        <property type="protein sequence ID" value="PPT16414"/>
        <property type="gene ID" value="CYQ11_07615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="33821" checksum="832D9588CBF1F6E7" modified="2018-01-31" version="1">MCAVRGLVKTYPAARGRRGGGAADVRASDGIDLDVRGGEIFGLLGPNGAGKTTLVRQLTGLLRPDEGSVDLLGHDLVRHPERAARLVGYLGQESTALDELTVALAAETTGRLRGLSLAAARAERDDVLDELGLGPLAGRPLKKLSGGQRRLACFAAALVGERPLLVLDEPTTGMDPAARRAVWAAVDRRRAEKGTTVLLVTHNVIEAETVLDRVAVLERGRIIACDTPAGLKELVGDEVRVDLVWRAEPPLDVPEVAALRGAARETGRRWSLRLAPAEARAAVAAVTGGPAFAALDDFTLATPSLEDVYLALGGGLAQGLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQT3</accession>
    <name>A0A2G1XQT3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000002">
        <property type="protein sequence ID" value="PHQ53596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53596">
        <property type="protein sequence ID" value="PHQ53596"/>
        <property type="gene ID" value="BLA24_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="12"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="265" mass="27820" checksum="B278268AB0D40B5C" modified="2018-01-31" version="1" fragment="single">VVETAARLGTRMHILHLSSAGALPVIAAAKARGVPVTVETCPHFLTLTAEEVPDGATEFKCCPPIREAANQDALWAALAEGTIDCVVSDHSPCTTDLKVPDFGRAWGGIASLQLGLPAVWTEARCRGHTLDDVARWMATAPAALAGLRHKGAIEAGRDADFAVLAPDETFTVDPAALHHRNPVTAYAGRTLHGVVRSTWLRGRRIATHGEPVGRLRGGWWSGERRRDSRPVLGGLGLGSGRALAGAREGRAGVRPGSACLGLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9P1</accession>
    <name>A0A2G1X9P1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31240</name>
        <name evidence="3" type="ORF">CYQ11_24280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47942">
        <property type="protein sequence ID" value="PHQ47942"/>
        <property type="gene ID" value="BLA24_31240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15566">
        <property type="protein sequence ID" value="PPT15566"/>
        <property type="gene ID" value="CYQ11_24280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="36166" checksum="21D865DAD834953D" modified="2018-01-31" version="1">MKYRELGAQGPEVSAIGLGCMGMSVAYGVPDEEESQHTLDRALELGVTLLDTADAYGQGLNEELVGRWLRRHPGDRDRMVVATKFGLRHDAATGRVGDVDTSAAYVPVACRASLRRLGVDHIDLYYAHRRNPATPVEETVGAMSRLVDEGLVRHIGLSEVSTATLRRAHAVHPVSAVQVEYSLFTRSVVEDELLATCRELGIAVVAYSPLGRGMLTGALASREDLGPQDNRRRWPRFADDNIDRNLALVRAVGDVAARLGCTPAQAALAWLLAQGDDVVPIPGTKRRRYLEENAGAVDLRLTPGDLDLLRAAVPEEAVAGERYPVQALERLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9W9</accession>
    <name>A0A2G1X9W9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ORF">BLA24_31700</name>
        <name evidence="6" type="ORF">CYQ11_24755</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48020">
        <property type="protein sequence ID" value="PHQ48020"/>
        <property type="gene ID" value="BLA24_31700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15646">
        <property type="protein sequence ID" value="PPT15646"/>
        <property type="gene ID" value="CYQ11_24755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="177"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="708" mass="79609" checksum="DBCFB2A13F384ADB" modified="2018-01-31" version="1">MQVWPGQAYPLGATYDGAGTNFAVFSEAAERIELCLLHDDGSETAVELRESDAFVRHAYLPGVMPGQRYGFRAHGPYEPERGQRCNSAKLLLDPYAKAVSGAVDWGEAVYGYHFGRPDKRNDMDSAPHMMTSVVVNPYFDWGDDRLPRTDYHRTVIYEAHVKGLTMLHPALPEEVRGTYAALAHPAVIEHLTELGVTAIELMPVHQFVNDHRLVDAGLANYWGYNTIGFFAPHNAYASWGDRGQQVLEFKSAVRALHAAGIEVILDVVYNHTAEGNHLGPTLSFRGLDNCSYYRLADDPRYYMDTTGTGNSLLMRSPHVLQLIMDSLRYWVTEMRVDGFRFDLAATLARQFHEVDRLSSFFDLVQQDPVVSQVKLIAEPWDVGDGGYQVGNFPPLWTEWNGKFRDTCRDLWRGEPATLAEFASRLTGSSDLYQEDGRRPLASVNFVTCHDGFTLHDLVAYNDKHNEANGEHNQDGESHNRSWNCGTEGASDDPAVLELRERQMRNFIATLMLSQGVPMLSHGDEFARTQHGNNNAYCQDNELSWVRWPSTADESSATARRMLRFTRSLVWLRRDHPVFRRRRFFHGRPIQGTGDDLSDIAWFTPEGEEMRDGDWQAAHAKSLTVFLNGGAISEPGPRGEPIVDDSFLLMFNAHDQPLDFVVPVDHGRQWQIVLDTARADGVTADGPKVQAGDRLTLTGRSLAVLQRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA03</accession>
    <name>A0A2G1XA03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_31880</name>
        <name evidence="10" type="ORF">CYQ11_24935</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48052">
        <property type="protein sequence ID" value="PHQ48052"/>
        <property type="gene ID" value="BLA24_31880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15678">
        <property type="protein sequence ID" value="PPT15678"/>
        <property type="gene ID" value="CYQ11_24935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="28401" checksum="A7A8C29CC846445C" modified="2018-01-31" version="1">MAFVNEWALAANIGAGLGFGAIIGLERQWRARMAGLRTNALVAAGSALFVLLSTYGFSSATSTSGYDGSRVAAQIVSGIGFLGAGVIMRDGLSVRGLNTAATLWCSAAVGALAGTGLYVLAALGTVGVVAANTLLRPLARGLDRGPHGGAEVSTDYHFEVVCTEPEEAHVRTLVVQAVARPGFRLRSVHSRDAETAGKVTVSAELTTERRDDSLLEEAVSRLSLEPAVSAVSWTVLQGPDDDDDDDADGGPDSGYGRGRRARRRVRNLFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAB2</accession>
    <name>A0A2G1XAB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32630</name>
        <name evidence="4" type="ORF">CYQ11_25680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48170">
        <property type="protein sequence ID" value="PHQ48170"/>
        <property type="gene ID" value="BLA24_32630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15796">
        <property type="protein sequence ID" value="PPT15796"/>
        <property type="gene ID" value="CYQ11_25680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="25409" checksum="8C21AD58C15CF0CA" modified="2018-01-31" version="1">MRLRVIGRDPLPEAWTPQGAPHVWLLRIDDRAPWRPEEYERVLDAQERTRAAGFVRPLHRERYVASHMALRQLLGAYTGTSPEAVALVREPCPGCGELHGRPAVAGSPPRLHFNLSHAGDLALLAFADTPVGADVERRQPDSVVADVSRLLHPKETEELDALPPARRAPAFARCWTRKEAYLKGTGTGLSEAPSVTYVGTGPAPVSPPGWTLTDVAVGEGYAGALAVRERADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAG0</accession>
    <name>A0A2G1XAG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dGTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32945</name>
        <name evidence="2" type="ORF">CYQ11_25995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48227">
        <property type="protein sequence ID" value="PHQ48227"/>
        <property type="gene ID" value="BLA24_32945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15854">
        <property type="protein sequence ID" value="PPT15854"/>
        <property type="gene ID" value="CYQ11_25995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13371" checksum="D238328708FD2764" modified="2018-01-31" version="1">MAARATTLKARATVREFALSLPGAGEEFPWGDSAVVKVNKKIFVFLGEEGNAENPAISLKLRDEEIHGHALAVPGAAPTGYGLGRSGWVTVPLTGADTPLEVLCDWVEESYRTVAPKRLVAQLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAJ1</accession>
    <name>A0A2G1XAJ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial collagenase</fullName>
            <ecNumber evidence="4">3.4.24.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_32735</name>
        <name evidence="16" type="ORF">CYQ11_25785</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.</text>
            <dbReference type="EC" id="3.4.24.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.3" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48189">
        <property type="protein sequence ID" value="PHQ48189"/>
        <property type="gene ID" value="BLA24_32735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15815">
        <property type="protein sequence ID" value="PPT15815"/>
        <property type="gene ID" value="CYQ11_25785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013661">
        <property type="entry name" value="Peptidase_M9_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08453">
        <property type="entry name" value="Peptidase_M9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758448" description="Microbial collagenase" evidence="13">
        <location>
            <begin position="31"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M9_N" evidence="14">
        <location>
            <begin position="137"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ48189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT15815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="782" mass="84497" checksum="DC33AB324BF4DA83" modified="2018-01-31" version="1">MNALRTARKGLLAATLAACLALPAAQAAAAAPGKPPTRPPVTATDVPGTPHDTPHKDPRTDVDRLAVAPEHRVEPPAPGGGKVSPGRIPGDLAEGKAGRPDGVAQGGAVPCTLDGITGLNPDRLADFLTDPAVTADGCLRGLIWTWDARLAPVMSRAHVQAVARRAASLAPSHGGTDATHLYELFTYLHAVVYHDFSRTEIDVTDAPTVDAMRRAIAAFGGAARTFDPTKQNADTLREALTTGSAPGLRQHQLGLISRVLDTLGPKAATATDPSWGGAALAALSTNYLGIYPGNNDTAFRNAVAANSAYRAGFRAFARHVHLKGTANAWAVRDALSEYGRFGQIDSLRTAIVGDLGALLKTAEGNFGDLSAPWASLASWLNFFEDCKRFNVCKPQIEARVFPRTYTYDKGGIEVRTALDRSTVDQLYYASKQVKAHFLRVLGTDAPLAGDPNATLHIHLYASRADYEVLHPLLTGMGTKNGGVYIEEGATFYTYQRRVPQDSQLTLEELFRHEYTHYLNGRWAVPGMFGDSRWFANDLTTAMDEGTAEFFDGATRDEGIKVRKSLVKGIIRDTAGGGPRMTVNRLLHSTYDGDGFRFYDYAGTFFEFLWEHHPSLLREMYGYQRADDPKGFDDWRTRTGADAGLQREYDAFLDEHIAKVDDLYVPATTFTPVGSLKLSRPTDVATAFASATQITPACTGNGDTGGKPRFTCTGRITANLTDSHDADQVFVDMTETVDYFILHRSESAANNFADMNCSFSSPEIWSTGSAATSSFSCEGPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAK3</accession>
    <name>A0A2G1XAK3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitosanase</fullName>
            <ecNumber evidence="1">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_33140</name>
        <name evidence="5" type="ORF">CYQ11_26190</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48258">
        <property type="protein sequence ID" value="PHQ48258"/>
        <property type="gene ID" value="BLA24_33140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15888">
        <property type="protein sequence ID" value="PPT15888"/>
        <property type="gene ID" value="CYQ11_26190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00978">
        <property type="entry name" value="chitosanase_GH46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.386.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000400">
        <property type="entry name" value="Glyco_hydro_46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023099">
        <property type="entry name" value="Glyco_hydro_46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01374">
        <property type="entry name" value="Glyco_hydro_46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036551">
        <property type="entry name" value="Chitosanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304863" description="Chitosanase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036551-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="297" mass="32129" checksum="68E950B24638C050" modified="2018-01-31" version="1">MPTRHTTGAATHVAARSTKKTTRVALLGMALALPASLAITGVGQAVPAGAAPLAAAARIQGAGLDDPHEKDIAMQLVSSAENSSLDWRKQFTYIEPYDDGRGYTGGIIGFTSRTGDMLELVERYTKAKPGNPLATYLPALRKVNGTDSHAGLGKPFEAAWHKAAEDKAFQDAQEAERDRVYFNPSVGLAKKDGLRTLGQFVYYDAIVMHGPGDDGDSFGGIRKAALAKAKSPAQGGDEKTYLNAFLDARKKVMKKEEAHSDTSRVDTEQRVFLNDGNFDLRPPLKWKVYGDSYRIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAL9</accession>
    <name>A0A2G1XAL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4255 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33225</name>
        <name evidence="3" type="ORF">CYQ11_26275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48270">
        <property type="protein sequence ID" value="PHQ48270"/>
        <property type="gene ID" value="BLA24_33225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15900">
        <property type="protein sequence ID" value="PPT15900"/>
        <property type="gene ID" value="CYQ11_26275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="22746" checksum="0B68EC4F0A7C2517" modified="2018-01-31" version="1">MIDLVDQALKSRVQHDVTWLPPGIPVTFQPPGRDGALGEAVGAETVGIYLYDLREDMDRRQTGTVYQYDRGTMGLPDRKSAEFDPPRYARLSYLIAAWAPDALSAHRILGELFVGFAKSRVFPVPLPPELQEMELSALLDVGHPPAEDRALTELWSAVGHTLVPALNVTVTVPLLSFLPDGYTHWVTGPPVVREVLKPGPGTDEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAQ2</accession>
    <name>A0A2G1XAQ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33435</name>
        <name evidence="3" type="ORF">CYQ11_26485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48306">
        <property type="protein sequence ID" value="PHQ48306"/>
        <property type="gene ID" value="BLA24_33435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15937">
        <property type="protein sequence ID" value="PPT15937"/>
        <property type="gene ID" value="CYQ11_26485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1192" mass="127018" checksum="F1EA4899764313FB" modified="2018-01-31" version="1">MSTLETVRVLRGVDLLDLTFRFVGLAFAEHSAGRRLVRADPRQEGLLVVVLGPQHVTEHAVAEGEPREVPVGSLVAGRTVLVFEVGPQDVIEYSEAGLLEAMRSLPPHVVDAAREADPPAPAPRPGLSRQLPAAVDDPAGRALVLARLLSAQAQLDARYGAAASAPATAAPQRVPQDPFADPASPRTGVELPYRLLLSPSQQARWSHRDAAGEPASGGRVELWHTRLSRTTVRAVWNRDRAPGTGQPEVSRLPLTAQDRTEIVELTSRDGLLTPQGQPCPPQPVDVEQLLLSAAGGWLDSSGQWPRRPRGISLSDWRHRATLGRDHYVRVMREGFLCPFGHRATLVKVTERTFAAPRAAFLSQRFFVVVRQRSRTYDPHEELPASTTDPTADLTNLLFPFTSVRLDTLVTPDLAPEPPTGAAFFPGTAAETPFRFRATAVDHEGRVVEFRTPLLFVPEELSTGAQLARIVDDYNAKSRPPTAAAGVAPDDELELTRAALQGQSVALAPSVQPDDTSVEVADLFWSVAAPPALADPGHAAPGEAAFLPQLSWANATLPAIGALSGGDRVVPVVYAPRYALSGFAHATSGGRTGNPGEVLLHVLASGDDALTMDFHGQAERSGGLLTPSFDVAGLSRKTGPVAGAAAGAEALNKIADGTFDPGDFFHPSEIIRNLDVNLLGVLSLADIVQKIEDATALPALHVPAFLTETVNAVTGFLTGLRRAGDFVANTSTGLPPAAGRVTETARNLARLVGDYLSQHLPGPPAAPPVTLEQIDAAFAAFSTALTDLLTALPRAADPGLRALLDRLRQEAGTWTAAAGQAPALRDALQAAAQGVKLPQTVQTRLEWNPAIQQWPSTDPLFAPHPDGRLSLVADLRGSLRPDVPPGADVSCSLENFDLVLVPPFKAMRLTFRHVRVTQRAGRKPDIDVALEDVAFIGALSFVQTLRRLIPLDGFSDPPGIQVTPAGITARYAMPLPNLAIGVFSLENIRLDAYLDLPFIGRPLEVGFSFCSRQAPFRLTVSMLGGGGFFGIVLTPKRVAVLEAALEFGAAVSMDFGVASGSLSVMAGIYFRLELDTGECRLTGYFRARGEVDVLGIVSASVELCLELSYDVDSGTVYGRARITVSVHIGFWSQSVSIECEKRFLGSGPAAAALAAEAPRPPTFAEMMSPYTDPVTGLRRDPVDEYCTAFAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB64</accession>
    <name>A0A2G1XB64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29390</name>
        <name evidence="3" type="ORF">CYQ11_06085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48478">
        <property type="protein sequence ID" value="PHQ48478"/>
        <property type="gene ID" value="BLA24_29390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12524">
        <property type="protein sequence ID" value="PPT12524"/>
        <property type="gene ID" value="CYQ11_06085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="33173" checksum="0283FCA5B81737B5" modified="2018-01-31" version="1">MTTTNPQAPAGEAVPDSPYTVPLAPGVHAYIQPDGGWCLNNAGFVTGAGRTLLIDTAATERRALALREAVLASGAPLPTTVVNTHHHGDHTYGNCVFTPEATVIGHADCRRETIAAGLQLHLAWPTVDYGAVEVTPPTLTFTDALTLHVGDIEVRLLHPGVAHTVGDTIAWLPEQGIVFTGDLVFNGGTPFIMMGSLSGSLRALETLRALDAHTVVPGHGRVTDPGAYDAVESYLRFVEDLARTSHAAGLTPLEAARRADLGEFAALPESERLVANLHRAYVELDGLPLGTPLDLVTVLGDMMVMNGGRPVACHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBB5</accession>
    <name>A0A2G1XBB5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Glycerol-3-phosphate dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_29595</name>
        <name evidence="10" type="ORF">CYQ11_05880</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48512">
        <property type="protein sequence ID" value="PHQ48512"/>
        <property type="gene ID" value="BLA24_29595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12489">
        <property type="protein sequence ID" value="PPT12489"/>
        <property type="gene ID" value="CYQ11_05880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="35"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="421"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="535" mass="57643" checksum="0941E97525F1A5BB" modified="2018-01-31" version="1">MTTPQSVPTLGTHPAAGINPGRAETRERLSNATYDLLVIGGGILGTSVAWHAAQSGLRVAMVDAGDFAGATSSASSKLVHGGLRYLQTGAVKLVAENHHERRVLAKDVAPHLVNPLTFYLPVYKGGPVGAAKLGAGVFAYSALSAFGDGVGKVISPAKAKADNPGLRTDNLKAVAVYYDHQMNDSRVAVMTVRAAVESGAVVLNHAEVTGLRFTHGKVTGAELKDRVDGTEFGIDARVVLNATGPWVDHLRKLEDKGAAPSIRLSKGAHIVMKRKSPWKAAMATPIDKYRITFALPWEDQLLLGTTDTQYEGDPADVRATEEDIQQILDEAAFSIQDADLDRDLMTYAFAGLRVLPGGPGDVAQAKRETVVSEGKGGMLSVAGGKWTTYRHIGRTVMSKLAKVPGSPLTEDMEPVSSLVRRTPLPGVANPNAVAHRLLVDREPGSRMDPLTARHLATHYGSLSFDIARLVNEDPELGERIHPDGPEIWAQVVYARDHEWAETVDDVLRRRTTLTIRGLDDENVRTRVKDMLNAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBK1</accession>
    <name>A0A2G1XBK1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ald</name>
        <name evidence="14" type="ORF">BLA24_01555</name>
        <name evidence="13" type="ORF">BLA24_29025</name>
        <name evidence="15" type="ORF">CYQ11_06450</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000026">
        <property type="protein sequence ID" value="PHQ53382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48581">
        <property type="protein sequence ID" value="PHQ48581"/>
        <property type="gene ID" value="BLA24_29025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53382">
        <property type="protein sequence ID" value="PHQ53382"/>
        <property type="gene ID" value="BLA24_01555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16382">
        <property type="protein sequence ID" value="PPT16382"/>
        <property type="gene ID" value="CYQ11_06450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="11">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ48581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ53382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT16382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="371" mass="39239" checksum="C28AD11927E213CC" modified="2018-01-31" version="1">MKVGIPREVKNNEFRVAITPAGVHELVRNGHQVFVEKGAGLGSSITDAEYVEAGAAILDTADDVWATADLLLKVKEPIAEEYHRLRKGQTLFTYLHLAASRECTDALLQSGTTAIAYETVELANRALPLLAPMSEVAGRLAPQVGAYHLMRSAGGRGVLPGGVPGTHAGKAVVIGGGVSGWNATQIAVGMGFHVTLLDRDVNKLREADKIFGTKVQTIVSNAYELEKAVVEADLVIGAVLIPGAKAPKLVTNELVAKMKPGSVLVDIAIDQGGCFEDSKPTTHAEPTFQVHDSVFYCVANMPGAVPNTSTYALTNATLPYIVELANRGWQEALRRDAALAKGLNTHEGQVVYGPVAEAHGLPQVELSSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBK7</accession>
    <name>A0A2G1XBK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28365</name>
        <name evidence="5" type="ORF">CYQ11_07105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48634">
        <property type="protein sequence ID" value="PHQ48634"/>
        <property type="gene ID" value="BLA24_28365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12687">
        <property type="protein sequence ID" value="PPT12687"/>
        <property type="gene ID" value="CYQ11_07105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758388" evidence="2">
        <location>
            <begin position="28"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="788" mass="83974" checksum="4C229D584A39939B" modified="2018-01-31" version="1">MRRRAQSVLALASLLLGGLAAAPAAQARPGPAAPPAGADALTAWTAQVTTEQVPLLLEAGVDGRELGERPAAGRPARVEVQLTGAQAEGLRAKGVDLVEKRLPQRTRERLKAAGDGVFRPYGGKNGLSQEIADTGRAHPRLTKVVSIGKTVRGQDILAVKVSKDARTTRDGARPAVLYMSNQHAREWITPEMTRRLLHHYLDRYGKDERITRIVDRTELWFVLSANPDGYDYTFQSPATRLWRKNLRDNDGDGKIAPGDGVDLNRNFPYKWGYDNEGSSPRPASETYRGPAPASEPETRALDAFQKQHDFTYAVNYHSAAELLLYGVGWQVATPTPDDVLYKALAGTPGNSAIPGYRPQLSSELYTTNGEADGHAANVNGTMMFTPEMSTCETASAVDPADRWDPSDCPSIFTFPDDEKLIQGEFAKNVPFALAVAETAGHPDRPSSPVGVDAPDFTPHAFATSYARGKDQTVAVTARKSLGDKRLNYRVDGGRTHSAPLAAWGGGDRYGGDDNLRFDQYRATVEGARPGSTVSVWFTGRTREGGRTASRPFTYKVAEQPRADTLVIADEGGGTPARQADDYVRALAADGREAVVWDVARQGAPPALGVLSHFDTAVWYSGTASPDGATLLAVRDFVNEGGKLVAAGVRAGGSSRVGDADTDDFAQYYLGAGSRTSYAAPSRFTGAGELTGTTAALGTPVAGAYTPVSDLLPPETFPRFRSAAAGEYTPAARTASPQSVTLREEGGGRRLAAAVTTRDTALLGFGLEHVPDARQRAVLIGAALRAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBW5</accession>
    <name>A0A2G1XBW5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28710</name>
        <name evidence="2" type="ORF">CYQ11_06755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48691">
        <property type="protein sequence ID" value="PHQ48691"/>
        <property type="gene ID" value="BLA24_28710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12628">
        <property type="protein sequence ID" value="PPT12628"/>
        <property type="gene ID" value="CYQ11_06755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="12921" checksum="C8378D7E3AC3BB83" modified="2018-01-31" version="1">MSFPCLLVDGDGWVMPCEDDAELQALTEPDFIDDIVAAFDATARPLKLHLVGEGHVIALRPTEEPRPDELAAHVRAYFHHWTDQEAPEAAQPMRLDVRSIADAVHATPTRRRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC14</accession>
    <name>A0A2G1XC14_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_28765</name>
        <name evidence="9" type="ORF">CYQ11_06700</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48699">
        <property type="protein sequence ID" value="PHQ48699"/>
        <property type="gene ID" value="BLA24_28765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12620">
        <property type="protein sequence ID" value="PPT12620"/>
        <property type="gene ID" value="CYQ11_06700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758392" evidence="6">
        <location>
            <begin position="35"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="176"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="515" mass="52369" checksum="BC66D79B867A391A" modified="2018-01-31" version="1">MAHLRSRRRHALLAAPIGLALTASLGFLPGTASAAAPGTGTKAAVTADGPLLSYVVNTGTDRATLAKVKKAVGQAGGTIVASYDRIGVIVAHSKNPAFGTTLRAVPGVQSAGATRTAPLKSAATTDYGKPEKLKLDKAGALAAARSAADGKEPLEGLQWDLGAIGADQAAKVNPGSKKVTVAVIDTGVDDTHPDLAPNFSASQSASCVTGKADTTPGAWRPNDPAEDYHGTHVAGTIAAARNGSGVAGVAPGVKVSGIRVSTPDKNSFFYAESVVCAFVFAADHGVSVTNNSYFVDPWMFNCPDNADQKAIADAVGRAAKYAEGKGIVNVASAGNSNFDLAAKEIADGGSPNDTTPQPRKIDPKQCLDVPAQLPGVVTVSATGVKSQKSFYSNYGLNAVDVAAPGGDSLQVPELPAKDGRILSTMPGGDWAYLQGTSMAGPHVAGVAALMKSAHPKSSPQEIQWLLKAQAKNPGCPTAAYDPDGTGKYKAACTGTQHVNSFYGFGIVDALAAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC25</accession>
    <name>A0A2G1XC25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28820</name>
        <name evidence="5" type="ORF">CYQ11_06645</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48709">
        <property type="protein sequence ID" value="PHQ48709"/>
        <property type="gene ID" value="BLA24_28820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12610">
        <property type="protein sequence ID" value="PPT12610"/>
        <property type="gene ID" value="CYQ11_06645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304790" evidence="2">
        <location>
            <begin position="41"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="24668" checksum="A216432F3D1E42E2" modified="2018-01-31" version="1">MRSAISGYSRLTKVHKLSAAGVAAVGAAALAFAVIPDASAGTEAHSVAVKPVAWNTNSFGETQQEELNKQSETAVKKAQADAEAKKKAEADAKAKADKERAEKAAASRSEERKPVQAAPAPAPAKKTYANNLDGWIKEALDIMKAKGIPGSYNGLYRNIIRESSGNPNAINNWDSNAAAGIPSKGLLQVIDPTFKAYHVDGTSWNIYDPVANITAACNYAAKVYGSMDNVNSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC29</accession>
    <name>A0A2G1XC29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27285</name>
        <name evidence="4" type="ORF">CYQ11_18370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48782">
        <property type="protein sequence ID" value="PHQ48782"/>
        <property type="gene ID" value="BLA24_27285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14569">
        <property type="protein sequence ID" value="PPT14569"/>
        <property type="gene ID" value="CYQ11_18370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="451"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="555" mass="58265" checksum="B6C0FEC905E7496B" modified="2018-01-31" version="1">MNDRHPSAGSGPTVPAPDGSYGHYGPYGQQSSQQTYAGYDGHAGYDTGQWAAPGASDTSGQWDTAAQWGVAGHTQTWDFSGHDLGAHDTGQHDLGTYGDQAPTGHGHDHHHSGQWDTSGAHSGQWDTGAWSAAGSAAGSYDTSGQGYQSGPWDTGAYDQAQHQGWNSTGQYAATAWNTVDQSAQPGGPSGQSDPSGQWDISTQQTQMWDTSAYASMDDHRPQSAAEPRHTATVPHTPTLMVDLSEAGLSDAGLPDAEPALAAQAPGARSVADAETRTMSVVEAEEAERDTAPSHQRETAPAPGRSARRKSNAPSRAGYRPRRKALLTVAVPSVAVMGVAGIAAASVVSGGDKEAPKATAAAAPDTSVKLSAANSQLDTQLAGLSRGADDFATRANRTQERIDLKARQDEERKRKAEEAARKERERPKFSLPVTQHGLSAMYGQAGVNWMSVHTGIDFPVSYGTPVMAATDGTVRTQYNVAYGNMAIVTAPDGTETWYCHLSSTKVRSGSVKAGDVIAYSGNSGNSTGPHLHFEVRPGGSAVDPLPWLRSHDLDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB5</accession>
    <name>A0A2G1XCB5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3027 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27750</name>
        <name evidence="3" type="ORF">CYQ11_17890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48858">
        <property type="protein sequence ID" value="PHQ48858"/>
        <property type="gene ID" value="BLA24_27750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14495">
        <property type="protein sequence ID" value="PPT14495"/>
        <property type="gene ID" value="CYQ11_17890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="296" mass="31178" checksum="D6652530091487B9" modified="2018-01-31" version="1">MRSRTPDRLCAEAVELARTAAEEAARPGKIGEHVEVAADGDRVVTHYFTCEDPGYRGWRWAVTVARASRAKVVTLDETVLLPGPDALLAPEWVPWSERLRPGDMGPGDLLPTEADDLRLEPGWTGEDAPPPNSAVSQEMAELAEAEDAEVSAGPPSAQPVAPARGSLSAVAEELGMRRARVLSRYGLHTAADRWDETHGAKTPMAQAAPASCVSCGFLVPIGGSLGQAFGICGNEFGPADGHVVSLSYGCGGHSEAAVMPKPPRPAPPVIDETLVEPLSLRTPDDEDADAEDLGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCD0</accession>
    <name>A0A2G1XCD0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28025</name>
        <name evidence="4" type="ORF">CYQ11_17615</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48907">
        <property type="protein sequence ID" value="PHQ48907"/>
        <property type="gene ID" value="BLA24_28025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14444">
        <property type="protein sequence ID" value="PPT14444"/>
        <property type="gene ID" value="CYQ11_17615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="164" mass="17973" checksum="B75B03A2FFFD150F" modified="2018-01-31" version="1">MSRSTNGADDTTNASSVPVPGAAQAGPISHAIFRVSRLHRMLAGQLLRRVGLHIGQELVMMQLWELGAQRQTDLVRLLDSDAATMTRTVQRLENAGFVRRRPCPGDRRAVLVEPTPASQALRQEVERLWAELEADATAGLTADERTETLRLLERIEAGLARATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCD6</accession>
    <name>A0A2G1XCD6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="3">4.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnD</name>
        <name evidence="4" type="ORF">BLA24_27725</name>
        <name evidence="5" type="ORF">CYQ11_17915</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48855">
        <property type="protein sequence ID" value="PHQ48855"/>
        <property type="gene ID" value="BLA24_27725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14498">
        <property type="protein sequence ID" value="PPT14498"/>
        <property type="gene ID" value="CYQ11_17915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="30682" checksum="5775E6BF9A605990" modified="2018-01-31" version="1">MSQPQEPGRPVRIAYSPCPNDTFVFDAWAHGRVPGAPALDVTFADIDVTNGMAERGEGDVLKVSYAVLPWVLDEYALLPCGGALGRGCGPLVLTREAGEPAGLAGKTVAVPSERSTAYLLFRLWAAAEVPGGVGDVVVLPFHEIMPAVRDGKVDAGLVIHEARFTYRDYGLSRLADMGEHWEDTTGLPIPLGAIIAKRSLGAARLRELAEAARTSVRMAWDDPAASRPYVLAHAQEMDPAVADQHIGLYVNEFTADLGEDGYAAVRGLLTRAAAEGLVPALGPDALTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCD9</accession>
    <name>A0A2G1XCD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12450</name>
        <name evidence="2" type="ORF">BLA24_28055</name>
        <name evidence="4" type="ORF">CYQ11_17585</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48913">
        <property type="protein sequence ID" value="PHQ48913"/>
        <property type="gene ID" value="BLA24_28055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51638">
        <property type="protein sequence ID" value="PHQ51638"/>
        <property type="gene ID" value="BLA24_12450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14438">
        <property type="protein sequence ID" value="PPT14438"/>
        <property type="gene ID" value="CYQ11_17585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014078305" evidence="1">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="118" mass="12641" checksum="D0CD809AF0E2422E" modified="2018-01-31" version="1">MKLRMWPLCAVSALAMLFPVTAAQAAPAAAAPACPGGSVCFYSGSDYSGKSWEWTANSGYRDLPPALHDHVGSFVANTDACFIAYQPTEKRAVHNGDWRRDYRGDFGGRMDGVGPGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCI7</accession>
    <name>A0A2G1XCI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27445</name>
        <name evidence="3" type="ORF">CYQ11_18200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48930">
        <property type="protein sequence ID" value="PHQ48930"/>
        <property type="gene ID" value="BLA24_27445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16641">
        <property type="protein sequence ID" value="PPT16641"/>
        <property type="gene ID" value="CYQ11_18200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18561" checksum="671722BD7C8E4A7F" modified="2018-01-31" version="1">MAVQGSEKSSRRGRRSTTMDGMPFNDMPWWRWRANVRSALHMLSDPVFQTECWLAGHEGYGDVTDAVYRLVEDTWLDNWSAEKYVGTVFRDSGEAALVDVAVLRVLRIMHQVGADAPVSAYLEHHGWAEAVRAAREAHVRLALNDGDDPEARPRPLAVLARLTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCK6</accession>
    <name>A0A2G1XCK6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27300</name>
        <name evidence="6" type="ORF">CYQ11_18355</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48925">
        <property type="protein sequence ID" value="PHQ48925"/>
        <property type="gene ID" value="BLA24_27300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16649">
        <property type="protein sequence ID" value="PPT16649"/>
        <property type="gene ID" value="CYQ11_18355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758319" description="NlpC/P60 domain-containing protein" evidence="3">
        <location>
            <begin position="42"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="241"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="37489" checksum="F1CFA0E1452E6D0B" modified="2018-01-31" version="1">MASHRKPKQNPFTGSTAARTAVTLALAGAATATALDGTGHAAPAPTPTQLKAQVARYYQEAEVATDRYNGVKERADRARAALDRLTDEAARKTERLNAARNALGSYATAQYRSGGVPVGVRLLLSDSPDRFLRDASLADRAGDRQAIAVARVRDELRDVRRVRTTADARLAELKGEQAALAAHKHIIETRLEEARRLLEKLPSEERAAVEGGDTGAAPVAHVADTAHAAVDSVQAAVPAPSSRAAQAVAYAYSAIGKPYVWGATGPSAFDCSGLTQAAWQAAGVSLPRTTYTQINAGRRVARSQLAPGDLVFFYSGISHVGLYVGHGQMIHAPHPGAPVRVAPISEMPFAGASRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM5</accession>
    <name>A0A2G1XCM5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23155</name>
        <name evidence="3" type="ORF">CYQ11_22920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49004">
        <property type="protein sequence ID" value="PHQ49004"/>
        <property type="gene ID" value="BLA24_23155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16739">
        <property type="protein sequence ID" value="PPT16739"/>
        <property type="gene ID" value="CYQ11_22920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="14"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="241" mass="25422" checksum="F1D411E6366FB484" modified="2018-01-31" version="1">MATSDPTAGAFASFTAVAHRGDPYVHRENTLPSVRSALRAGAGAVEIDVRLTRDGVPVLLHDATLGRLWGVDRPLAAFSADELREVTGGGVPTLREALAEAAAAGTGRLFVDLPDPSAAAAAVAEVHASGATERVYYCGGPAAMLNVRRADPDAEIALTWTTLAPPRAALLAGVRPHWLNYRFGLVTPELVARDHANGLRVSAWTADTRRTMRRLLRAGVDSITTNRIGTLRALLPAPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCS6</accession>
    <name>A0A2G1XCS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23495</name>
        <name evidence="4" type="ORF">CYQ11_22575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49057">
        <property type="protein sequence ID" value="PHQ49057"/>
        <property type="gene ID" value="BLA24_23495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15297">
        <property type="protein sequence ID" value="PPT15297"/>
        <property type="gene ID" value="CYQ11_22575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="27906" checksum="02219531C0E73628" modified="2018-01-31" version="1">MSRHRIGFWYRFTAVLAKPPLVVLFKRDWRGTEHIPVDGGFITAVNHNSYLDPLSYAHFQYNTGRVPRFLAKAALFKGSFVGTLLRGTGQIPVYRESADAATAFRAAVDAINKGECVAFYPEGTLTRDPDMWPMEGKTGAARVALLTRAPVIPVAQWGANEAMPPYAKEKKLRLFPRKTLKVMAGPPVDLSAYYGQEPTAEVLREATDTIMRAITDLLAELRGEPAPAEPYNLKKARAAARREAGSPEGDDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT4</accession>
    <name>A0A2G1XCT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_23530</name>
        <name evidence="6" type="ORF">CYQ11_22540</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49064">
        <property type="protein sequence ID" value="PHQ49064"/>
        <property type="gene ID" value="BLA24_23530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15290">
        <property type="protein sequence ID" value="PPT15290"/>
        <property type="gene ID" value="CYQ11_22540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="71"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="242" mass="25359" checksum="3A64E5E533D28905" modified="2018-01-31" version="1">MDNSSGASSGVGVLDKAALVLSALESGPATLAGLVTATGLARPTAHRLAVALEHHRMVARDMQGRFILGPRLSELAAAAGEDRLLATAGPVLTHLRDVTGESAQLYRRQGDMRICVAAAERLSGLRDTVPVGSTLPMKAGSAAQVLMAWEEPERLHRGLQGARFTATALSGVRRRGWAQSIGEREPGVASVSAPVRGPSNRVVAAVSVSGPIERLTRHPGRMHAQAVLDAAIRLTEALRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD32</accession>
    <name>A0A2G1XD32_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_24055</name>
        <name evidence="6" type="ORF">CYQ11_22015</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49146">
        <property type="protein sequence ID" value="PHQ49146"/>
        <property type="gene ID" value="BLA24_24055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15203">
        <property type="protein sequence ID" value="PPT15203"/>
        <property type="gene ID" value="CYQ11_22015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="239" mass="25277" checksum="058D5736C5A77CC1" modified="2018-01-31" version="1">MSTSPGQAPAIRVLVVEDDPVAAAAHALYVGRVPGFTVAGVVHSRGDASQFLKRSAADGRPAVDLLLLDLYLPDGHGLALVRSLRTAGHGADVIAVTSARDLAVVREGVSLGVVQYVLKPFTFATLRDRLVRYAEFRAAAGEASGQEEVDRALAVLRAPQPVALPKGLALDTLQAITETLRAAGDEGISSGAAATAMGISRITARRYLEHLVGTGRAVRAPRYGQVGRPELRYRWLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDG3</accession>
    <name>A0A2G1XDG3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24730</name>
        <name evidence="4" type="ORF">CYQ11_21340</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49268">
        <property type="protein sequence ID" value="PHQ49268"/>
        <property type="gene ID" value="BLA24_24730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15080">
        <property type="protein sequence ID" value="PPT15080"/>
        <property type="gene ID" value="CYQ11_21340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="23845" checksum="1B1FF19BEBA6796C" modified="2018-01-31" version="1">MIVYLLPAIPGLMTLGALAMVAGAVLRRRRLKAAWSGGIAVQGRCLRTYVTTTVWRRGHHESASSSLSHVYEFTDQDGRTRRFEEDGRGTVFEGDAVVVRYPPGRPDRATALEPDDPRARAKTRLQMGFGVFATLLCVAATAVFLTATSVFQSAKDEVDDFRKRPPAEQRQEPRQPSATGWPAELPAPPVTLPTDLPVPPGPPMPSDPPMPPGFPAKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDI8</accession>
    <name>A0A2G1XDI8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HD-GYP domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_24935</name>
        <name evidence="6" type="ORF">CYQ11_21135</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49304">
        <property type="protein sequence ID" value="PHQ49304"/>
        <property type="gene ID" value="BLA24_24935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15045">
        <property type="protein sequence ID" value="PPT15045"/>
        <property type="gene ID" value="CYQ11_21135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304904" evidence="3">
        <location>
            <begin position="32"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="218"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="447" mass="47113" checksum="D1DD5578D9157AC6" modified="2018-01-31" version="1">MWALPAAARAYIACAVLAAAVCALPAVRAGAAVPWGPVLLLAGVCVVCERLPRCPLTLPVLLAGAFLLPPGAAGLVAVPGALAGRVAQRPAWLRRLWHAAQSSLAANAASYVYGRGAPRVVTAPDFPHALVPALVAALVLALVVTALDGGVLVTAEGRSPRTAWRGPLPAALVPPLAHGPTGLMTAVLWHSPYGPPAALLVLLPMAVSSWVQGRCRRERAAHQATVRALVQAVDLKDRYTRGHSERVGRASVLIARELGISGDRLEALRFAGTLHDVGKLGVPTRLLRKDGPLTPEERRVIELHPEYGHEMVRGIGFLDEARAAILHHHERLDGTGYPYGLKGCQIPEFARVVSVADAFDAMTSTRSYSRARPVPVALDELHRCSGTHFDPAMVAALARALDRHGWHPAFAPDPQEPAVPVSRNVPLDHCSAPGAPAGTDARPGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE51</accession>
    <name>A0A2G1XE51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26085</name>
        <name evidence="3" type="ORF">CYQ11_19980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49506">
        <property type="protein sequence ID" value="PHQ49506"/>
        <property type="gene ID" value="BLA24_26085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14843">
        <property type="protein sequence ID" value="PPT14843"/>
        <property type="gene ID" value="CYQ11_19980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045733">
        <property type="entry name" value="DUF6087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19565">
        <property type="entry name" value="DUF6087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="10911" checksum="106744BCAFB18CFF" modified="2018-01-31" version="1">MNDEPLEEWAERREAKIGRLRAVPIVTGDGPRGAHLNPDAPRAIERWNGYSWEPYAFAASLAEAKRILYPEAQTSPSTTPSPARQPLAPGTGRHRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XED1</accession>
    <name>A0A2G1XED1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate/guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26525</name>
        <name evidence="5" type="ORF">CYQ11_19110</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49582">
        <property type="protein sequence ID" value="PHQ49582"/>
        <property type="gene ID" value="BLA24_26525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14699">
        <property type="protein sequence ID" value="PPT14699"/>
        <property type="gene ID" value="CYQ11_19110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032026">
        <property type="entry name" value="Ad_Cy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16701">
        <property type="entry name" value="Ad_Cy_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="208"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="41427" checksum="F150853E2147066B" modified="2018-01-31" version="1">MTADETGSAAPGAAEEGPPDEAARGRGDAGDPAAREVEEDFDEEEGDPLALRLESLILGAERRYTPFQAARAAGVSMDLAARFWRAMGFADIGQAKALTEADVLALRRLAGLVEAGLLSEPMAVQVARSTGQTTARLADWQIDSFLEGLTEPQEPGMTRAEITYPLVELLLPELEEFLIYVWRRQLAAATGRVVQAQDDAEMVDRRLAVGFADLVGFTRLTRRLEEEELGELVEAFETTAADLVAAHGGRLIKTLGDEVLYAADDAGTAAEIGLRLIETLSHDETMPELRVGIAFGTVTTRMGDVFGTTVNLASRLTSIAPKNAVLVDGALAEELTRSGDAPKSEADAAAAEDHPAYRFALQPMWQRPVRGLGVVEPWLLTRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEG1</accession>
    <name>A0A2G1XEG1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26720</name>
        <name evidence="3" type="ORF">CYQ11_18915</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49616">
        <property type="protein sequence ID" value="PHQ49616"/>
        <property type="gene ID" value="BLA24_26720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14664">
        <property type="protein sequence ID" value="PPT14664"/>
        <property type="gene ID" value="CYQ11_18915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19487" checksum="63E3767D9C6E6DEF" modified="2018-01-31" version="1">MYVMTTATAPVSVPAPLWARRAAHAIALCALPSGLWRVAMASGVYVGYSEQVLRDVFAIPGWGIAYVVGLSVLSEAAALFPLLLVSDRWRPLRPRTLARLAWTASAVLVLAALWQVVVAFTVESRTYMTSGTAHTVWAFVFAPLFAIPALMTAVTWSYAKRQRAHGRAVSERCLTSPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEM7</accession>
    <name>A0A2G1XEM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_26925</name>
        <name evidence="9" type="ORF">CYQ11_18710</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49651">
        <property type="protein sequence ID" value="PHQ49651"/>
        <property type="gene ID" value="BLA24_26925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14627">
        <property type="protein sequence ID" value="PPT14627"/>
        <property type="gene ID" value="CYQ11_18710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="24845" checksum="2EDEA86469F099BE" modified="2018-01-31" version="1">MVQDVGVQGDDAELTVAVRAAQDGDETAFRTVYRSVHPRLLGYVRTLVGEADAEDVASEAWLQIARDLERFTGDADRFRGWAARIARNRALDHIRMRGRRPAIGGDESELAGRAADADTAREALESLGTGQTLALIAQLPQDQAEAVVLRVVVGLDAKSAAGVLGKRPGAVRTAAHRGLRRLAELVTGGGTGAGRGRQAVAEGIPGRRQSHTEPDGTNASAGVTQLRPRTQKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XES6</accession>
    <name>A0A2G1XES6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25710</name>
        <name evidence="4" type="ORF">CYQ11_20360</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49737">
        <property type="protein sequence ID" value="PHQ49737"/>
        <property type="gene ID" value="BLA24_25710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16689">
        <property type="protein sequence ID" value="PPT16689"/>
        <property type="gene ID" value="CYQ11_20360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="270" mass="30030" checksum="67ABC61151B39818" modified="2018-01-31" version="1">MIESAVKEKRIAENPAVGVKIARTSSIAVDEDEIPTLEEVDLLAHHIAQQYRLTIYLMSGAGLRPSEALAFASECRRTEFIRVRWQVSAKANAGDCRTTFVPLKHRAEGEYRDIPIALFLEEEIDAHVEQWEPIPVTFQNKAGKDKQLEVFFAPRDRGKGTMPTASTFGYHFKKACKAAGLVDANGKPKYTPHSLRHFFASTALANGIPIHEVSRWLGHKSIKITADVYGHLVPGAWHRCREVMQNAMRPVPLDVESPASKEAEGYGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFR6</accession>
    <name>A0A2G1XFR6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20775</name>
        <name evidence="4" type="ORF">CYQ11_10005</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50045">
        <property type="protein sequence ID" value="PHQ50045"/>
        <property type="gene ID" value="BLA24_20775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13177">
        <property type="protein sequence ID" value="PPT13177"/>
        <property type="gene ID" value="CYQ11_10005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="41349" checksum="E6067316008452FA" modified="2018-01-31" version="1">MSPTATPATVATAPLSRPAEAPAGTPTPAARDPFFDNAKYLAIVLVVLGHAWQPLTYTSRAATALYMLVYAFHMPAFILISGYFSRGFDMSPAKVKRLMTSIVVPYVIFEVAYTWFQHWGEDAPPEPISLLNPYYLNWFLAALFVWRLTTPVWKVLRWPVPVAFVIAVLAAVCPDLGADFDLQRVFQFLPFFVIGLRMKRSHFELVDRRWVRIAAVPAFAAALGAAYWLAPTWDDGWLFHNYSVQELHAPLWMAPVMVFALFGVAAVLTAGFLAWVPRRTTWFTALGGGTLYGFLLHGFLIKLSRWQEWYEAADWIRSPAGLVVVTVLAVTMISVLCSAPVRRVFRYVVEPRMDWAFRAEAGRKPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFR9</accession>
    <name>A0A2G1XFR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease E/G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50067">
        <property type="protein sequence ID" value="PHQ50067"/>
        <property type="gene ID" value="BLA24_20935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="585"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="964"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="1227" mass="129946" checksum="2DE1853B49EE4E3B" modified="2018-01-31" version="1">MEAAVEPAEAAEAPAEAAAPVRARRRATRRASAPAGAPQAAEPLAAAEEEEVEAPEAAAEPAEAAAPVRARRRATRRASAPAGAPQAAEPLAAAEEEEVEAPEAAAEAAEAAAPVRARRRATRRASAPAGAPQAAEPLAAAEEEEVEAPEAAAEPAEAAAPVRARRRATRRASAPAGAPQAAEPVTEPVEAEEAEALEAAAEPAAAPEAPAAKPARTRRRATRAVSAPTGEPLAAEPTVAETTEAVAEAAPVIARGAEEAPAAKPARRRRATRQAGTAEAAAPEAPAAEPAPAEGGRGRRRAVRPPTAVFQAPVFAEPMFQTPETAAAAAAAATVAEEEREEEAPAAEAAQPAAGRRRRRRRGEPAEIVAEPAAEAVEEEPEAAEEEPEGALAEDEDQGERTSRRRRRGGRRRRRGEAAEAEGGEEEPSYTEEAAEAAEEEAEEEAEEAGASASAGSRRRRRRRRRSGETAETEPGTDEPERTVVKVREPRKREEREPGTGFDEVQSIKGSTRMEAKKQRRREGREQGRRRVPIITEAEFLARREAVERVMVVRQHGDRTQIGVLEDNVLVEHFVNKEQATSYVGNVYLGKVQNVLPSMEAAFVDIGKGRNAVLYAGEVNFDALGMGNGPRRIETALKSGQSVLVQVTKDPIGHKGARLTSQVSLPGRYLVYVPEGSMTGISRKLPDTERARLKQILKKIVPEDAGVIVRTAAEGASEDELRRDVERLQAQWEEIQKKSKQISTSSPSLLYGEPDMTVRVVRDIFNEDFSKVIVSGEQAWETIHGYVSHVAPDLADRLQKWTSDVDVFATYRIDEQLMKALDRKVWLPSGGSLVIDRTEAMVVVDVNTGKFTGQGGNLEETVTRNNLEAAEEIVRQLRLRDLGGIIVIDFIDMVLESNRDLVLRRLLECLGRDRTKHQVAEVTSLGLVQMTRKRVGQGLLESFSEQCVHCNGRGVIVHMDQPAAVGGGGGKRGKKKGKGAVEAQPAAEAVTEEVVDEAPEAPELEPVAVTEAELEPSVGGDEEWFGSPAEAEAAASRRGGRTRRRATRKVSAPAGSPKAAEAVEPEIVVPAVPVEAAPEPEPAPAPAEPEAVEPVAEAVVATESAAPARPRRRATRKASAPAGAPAGAEEAAVVVVSAPVAEPAAEPAAEPAAEPAPVLTEEAEEAAPAKKTARKTAAKKAPAKKAATAKKTAAKKTTAKKATAKKAATKKAPAKKTAKKAAASSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFT2</accession>
    <name>A0A2G1XFT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21125</name>
        <name evidence="3" type="ORF">CYQ11_09660</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50098">
        <property type="protein sequence ID" value="PHQ50098"/>
        <property type="gene ID" value="BLA24_21125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13122">
        <property type="protein sequence ID" value="PPT13122"/>
        <property type="gene ID" value="CYQ11_09660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="350" mass="35939" checksum="04A3857F92AC896A" modified="2018-01-31" version="1">MAPLTGLFEHPIVQAPMAGASSPVLAAAVSDAGGLGFLAAGYRTPAAMREQITRLRALTARPFGVNLFMPQPPVTDPAAVDAYAGRLADESARYATPLGDWDQSTDDAYDAKLAVLLDDPVPVVSFHFGCPDRDVLHALAAAGTVTMVTATSATEALAAQEAGAAAVCVQGVEAGGHQGTHRDDPRADGTGRGLLELLAEVRASVTIPLVAAGGLMRGDHIATALAAGACAAQLGTAFLPCPESDANPLHKRALTDPAFARTELTRAFTGRPARGLVNRFIREHGPAAPAAYPQLHHLTSGLRKAAAAAGDPQAMALWAGEGHRLARALPAGELVAVLAAELDRARKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG10</accession>
    <name>A0A2G1XG10_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ORF">BLA24_21605</name>
        <name evidence="15" type="ORF">CYQ11_09180</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50174">
        <property type="protein sequence ID" value="PHQ50174"/>
        <property type="gene ID" value="BLA24_21605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13043">
        <property type="protein sequence ID" value="PPT13043"/>
        <property type="gene ID" value="CYQ11_09180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="8"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ50174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="420" mass="43407" checksum="EC811F3A0D56CF17" modified="2018-01-31" version="1">MNSTNRTVVVTGIGATTPLGGDSASTWEGLLAGRSGVKPLESERFADLPVRIAASAAVDPEDVLPRPLVRKLDRSAQFALIAAREAWADAGFTGKAGDDSAIAPERLGAVIASGIGGVTTLLDQYDVLKEKGARRVSPHTVPMLMPNSPSANVGLEVNARAGVHTPVSACASGAEAIGYAYEMIRSGRADIVVAGGTEAAIHPLPVAAFASMMAMSKNNDDPTRASRPYDKGRDGFVLGEGAGVVVLESAEHAAARGARVYCEVLGQGLSADSHHIAQPEPTGRGIAAALQNLLDSTDLKPAEVVHLNAHATSTPQGDAAEIKALRKVLGDDLDHVAVSATKSMTGHLLGGAGGIETVMSVLALYHRTAPPTINVDELDEDIDADIVRDEPRQLPEGSIAAINNSFGFGGHNVVLALRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG80</accession>
    <name>A0A2G1XG80_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22020</name>
        <name evidence="4" type="ORF">CYQ11_08765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50243">
        <property type="protein sequence ID" value="PHQ50243"/>
        <property type="gene ID" value="BLA24_22020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12972">
        <property type="protein sequence ID" value="PPT12972"/>
        <property type="gene ID" value="CYQ11_08765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="290" mass="29760" checksum="1D5CFF0877FF74C3" modified="2018-01-31" version="1">MNIRSLTRGDGVVIGAAVLLFIASFLSFHSYDCGPSPIGAMGCPKEPTGWKPDLFPVLPSIFLAGIIAAALVIAARFQPEGRKLVGLSLDQWGIALSVFAAWSSLWTIFGGPDSDRVSPGVGQILALIATLVLAAVSALTPRVPALKAPLLSAPQPAPAPYGAQPGQGYGYPAPGGMQPGAPYGAQQQPSFGGAPQAGPTQVQPQQGPEAAQPAAAGQPAAPAGGDFTPFWFAVPVNRPLFPEDGSQTPIAELAPGTWYLAVDQRGPALVAQTQDGRRGVLQDTTGIQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGC7</accession>
    <name>A0A2G1XGC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22330</name>
        <name evidence="3" type="ORF">CYQ11_08455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50293">
        <property type="protein sequence ID" value="PHQ50293"/>
        <property type="gene ID" value="BLA24_22330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12921">
        <property type="protein sequence ID" value="PPT12921"/>
        <property type="gene ID" value="CYQ11_08455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="29787" checksum="CF8D74037219A6BF" modified="2018-01-31" version="1">MLRVGGVALHVVREGSGPVCVLSAGLGMGWFDWEPVVPLLTPHRTVVRFDRPGLGFSAPALEPPTATAEADRIAGVLDALGLPGQATVVGHSLAAFHAEAFARLHPDRTAGLVLADPGVLEEDARPVPGLGLRTAAAQARGAAFAAAGLPRALGPALRRLSARSASLARRDPAPAELVRRVYGSGRVARAVLMENARYRDVAAELADLRGRHALPPVPVTVLAASTGTGSWLERRWLTRQRALAERLDGRFEAVAPAGHLLMYDRPQAVAAAVLATPFLRGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGJ4</accession>
    <name>A0A2G1XGJ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22665</name>
        <name evidence="4" type="ORF">CYQ11_08125</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50347">
        <property type="protein sequence ID" value="PHQ50347"/>
        <property type="gene ID" value="BLA24_22665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12865">
        <property type="protein sequence ID" value="PPT12865"/>
        <property type="gene ID" value="CYQ11_08125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="437" mass="45114" checksum="90EEF8205D150A18" modified="2018-01-31" version="1">MTSLAATGLARPHRWLRAHPLAADTLPAAAVLAVILLGVYVSPRGGPQRPPDALFLLSAAAACAALVARRRAPRAVVAITSALTVLVTVVPREGPPRTHVALAVAVALYTVASRTERPTAWRIVAGTVAALTGTVMLFGPPPWYAQEYFGLVAWTGMAGAAGDAVRSRRAYVAAIEERAVRAERTREEEARRRVAEERLRIARELHDVVAHHIALVNVQAGVAAHIMDSRPEQAKEALAHVREAGRSALEELRATVGLLRQYGDPEAPTEPAPGLGVLDQLVDGFARVGLRVEVNVASSLPGGPGASASAAEAAGVVGPLPGAVDLTAYRVLQEALTNVHKHAGPGARAQVAVVRSPRSLVLTVLDDGAGGGDGPSVDLIGGPAGGHGLIGMRERAVALGGTCEAGPRGRGTPGFQVRAVLPLQSRAEAAVPAPGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGP7</accession>
    <name>A0A2G1XGP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50309">
        <property type="protein sequence ID" value="PHQ50309"/>
        <property type="gene ID" value="BLA24_22425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="42" mass="4927" checksum="9C31DC4C6968D22A" modified="2018-01-31" version="1">MAGYQNTSTGRDDLEPFWPSRQHHDFDRVCCRASFTRAHSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT0</accession>
    <name>A0A2G1XGT0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_16500</name>
        <name evidence="5" type="ORF">CYQ11_16785</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50448">
        <property type="protein sequence ID" value="PHQ50448"/>
        <property type="gene ID" value="BLA24_16500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14300">
        <property type="protein sequence ID" value="PPT14300"/>
        <property type="gene ID" value="CYQ11_16785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="197"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="398" mass="42405" checksum="51C9AD63133BB5FB" modified="2018-01-31" version="1">MQRLYDFLRRHPTGVDSFWALLLLGISGLSIAEGAGSGSRAVLVLTTLTLCLVIALRRRFPEKMLLLATAAGLVQLACDISANVADFAMLVIIYTVASGGTRWASRYALVGGLAAPAIASLRWPDGHQSVGQAIVATAFVTVPFVLAWVLGDSVRTRRAYWAQLEEKARRLEKEREQQAQIAVTAERARIARELHDVVAHNVSVMVVQADGAAYVLDASPEQAKQALETISGTGRQALAEMRRLLGVLRTEEGGEGGSYVPQPDVEQIGELVEQVRGAGLPVDFQVEGAPRPLPSGVELTAYRIVQEALTNTRKHGGPDVGASVRLTYFDDGLGLLVEDDGRGAQHELYESGGADGMGHGMIGMRERVGMVGGTLDAGPRPGGGFRISALLPIKPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGY4</accession>
    <name>A0A2G1XGY4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_16530</name>
        <name evidence="7" type="ORF">CYQ11_16755</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50451">
        <property type="protein sequence ID" value="PHQ50451"/>
        <property type="gene ID" value="BLA24_16530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14294">
        <property type="protein sequence ID" value="PPT14294"/>
        <property type="gene ID" value="CYQ11_16755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="239" mass="25250" checksum="F3D34F01D6CC326D" modified="2018-01-31" version="1">MAHQNCLITNDWICGAYVRTRSQELTDATLQHIGITLASVAIGLLVAFPLALVARRWKVVAGPVLGATTVLYTVPSLAMFSLLVPVFGLSAAVVVTGLVLYSLTVLVRNILAGLAAVPEETREAARGMGYGPVRLLFGVELPLALPAVMAGLRITTVSTVSLTTVGAIIGYGGLGNLLYDGMRSYFKAQVLTASVLCVALAVLADLALLLVQRLLTPWTRTRRRAGKRGRVVVEKAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH42</accession>
    <name>A0A2G1XH42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17225</name>
        <name evidence="2" type="ORF">CYQ11_16050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50558">
        <property type="protein sequence ID" value="PHQ50558"/>
        <property type="gene ID" value="BLA24_17225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14188">
        <property type="protein sequence ID" value="PPT14188"/>
        <property type="gene ID" value="CYQ11_16050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18035" checksum="1C4B2AAFDCE92228" modified="2018-01-31" version="1">MLLSDADGLFAALAAMDLPKGDYVVCGSAALYVRGLRPRMGDLDVLARGAAWERALTLGEPEATVSGYGRRVVHPTADIEIMDRWTPGWSVDRLIDDADVIDGVPFMRLGDVLRWKIAASRPKDLPDIAAIRRLYGVWAGRNEPPLFTAPAPEAAPPEHHDHQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHA8</accession>
    <name>A0A2G1XHA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17310</name>
        <name evidence="4" type="ORF">CYQ11_15965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50571">
        <property type="protein sequence ID" value="PHQ50571"/>
        <property type="gene ID" value="BLA24_17310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14175">
        <property type="protein sequence ID" value="PPT14175"/>
        <property type="gene ID" value="CYQ11_15965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="7529" checksum="11B6DD8E3D1EF746" modified="2018-01-31" version="1">MANPHQQSPEGAYDPAGNTQMFRAFVDEGPTGRRTPAAPASSRARASSGPRPGMIIGVIVALAVVAGAVWLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHD8</accession>
    <name>A0A2G1XHD8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17780</name>
        <name evidence="4" type="ORF">CYQ11_15495</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50646">
        <property type="protein sequence ID" value="PHQ50646"/>
        <property type="gene ID" value="BLA24_17780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14099">
        <property type="protein sequence ID" value="PPT14099"/>
        <property type="gene ID" value="CYQ11_15495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="27674" checksum="C4A8383A6CE639F8" modified="2018-01-31" version="1">MAPRSASSSPSWVPAPRRADARRNRVLVMQAARSAFEEAGLAVPLGEIARRAGVGAGTVYRHFPSKEALFRATVVDRVRLFTDTARELATAEQPGVVFFRYLAAVVRLSVRNKGLCDALEGNFEPSPGVEEGFRAALCVLLERAQQAGAVRKDVAIDDVMALLLGCLSMEQRRGPGVAPGRMTALACDSLRPGRRVTKLPQNPRATRNETVCAVCGGPVAAARTGRPARYCGGACRQKAHRERARARAGSEVVLEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHQ2</accession>
    <name>A0A2G1XHQ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18475</name>
        <name evidence="4" type="ORF">CYQ11_14805</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50762">
        <property type="protein sequence ID" value="PHQ50762"/>
        <property type="gene ID" value="BLA24_18475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13980">
        <property type="protein sequence ID" value="PPT13980"/>
        <property type="gene ID" value="CYQ11_14805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="233"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="434" mass="46043" checksum="F8B34567D88BE104" modified="2018-01-31" version="1">MGIRSLLRNAFGRSRTTGRDEPSLPQQSAGPDSTPAATVSVPAQPTAETADRVGQSAPEAASEQVVETVPEQVAAAAAERVAEDVPGPAGATVPDPGPLGPIPIPGPPRPEPVPEPEPEPTPMPQPKPVPQPEPTPRPDPNPVPEPPPGPDPEPAPAMETAPVETAPTAPPGTEPLPEPDPVPTPVPDPEPEPEGAPAISLEKVRATAPALVSLYKTAGVSLKKQGLAGRRAAVYLVLDRSGSMRNYYKDGTVQHLAEQALGLAAHLDDDGVVPVVFFSTDVDGTAELDLTDYEGRIQELHASYGHMGRTNYHWAIEAVVDHYKKSGATDPAFVIFQTDGAPYSKAAAEKALCEAAKLPIFWQFVGFGDPEGKGFDFLRKLDDLAVPEKRVVDNAGFFHAGREPKLLSDGELYKELMVEFPEWLEEARAAGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHR7</accession>
    <name>A0A2G1XHR7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_18280</name>
        <name evidence="11" type="ORF">CYQ11_14995</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50731">
        <property type="protein sequence ID" value="PHQ50731"/>
        <property type="gene ID" value="BLA24_18280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14013">
        <property type="protein sequence ID" value="PPT14013"/>
        <property type="gene ID" value="CYQ11_14995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="37"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="528" mass="54964" checksum="7264845A63E4D6A6" modified="2018-01-31" version="1">MAQTQSAQGPDPDANGGGMPDVPEMWGNGGLVGDGRYRLTHRLGRGGMAEVFAAEDVRLGRTVAVKLLRADLAEDPVSKARFTREAQSVAGLNHHAVVAVYDSGEDTVGRNVVPYIVMELVEGRTIRDLLLNAEAPPPEQALIIVSGVLEALAYSHQHGIVHRDIKPANVIITNTGAVKVMDFGIARALHGAASTMTQTGMVMGTPQYLSPEQALGKTVDARSDLYATGCLLYELLALRPPFTGETPLSVVYQHVQDIPVPPSQVQGSVPPELDGLVMRSLAKDPDDRFQSAEEMRGLVQYALQMLHEAGSHTGAWDTGPIEHAAAATQVMGAMGAGATTAMPHPHGNTSQQPLLPPRRGDDGGFDGYNGGGRGAGGAGKNKLWLVAVLAVVAVAVGAFFLLKPDNTSSKGTNPKPDKQSSSPSSPTPSTSKSPSSKHNGSATARPGAGDDDTSDRDDTGWQTREPSDESTRRHTKQPSQGPSGEASGPPKPSTDPTSKPSDDPKPQSPPPASPGAAAGGNTVMGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHT1</accession>
    <name>A0A2G1XHT1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">BLA24_18640</name>
        <name evidence="11" type="ORF">CYQ11_14640</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50790">
        <property type="protein sequence ID" value="PHQ50790"/>
        <property type="gene ID" value="BLA24_18640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13952">
        <property type="protein sequence ID" value="PPT13952"/>
        <property type="gene ID" value="CYQ11_14640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="157"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="223"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="157"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="390" mass="40447" checksum="86B01ED097DD08EB" modified="2018-01-31" version="1">MSLSRDLLEKDLYKVLGVPKDATEAEIKKAYRKLAREFHPDANKGDASAEERFKEISEANDVLADPKRRKEYDEARALFGNGGFRPGPGGAGGSFNFDLGDLFGGAQGGAGAGGFGGGLGDVFGGLFNRGTTTRTQPRRGQDVESEVSLSFAEAVEGATVPLRMSSSAACKACSGTGDKNGTPRVCPTCVGTGQVSRGAGGGFSLTDPCPDCRGRGLIPEHPCDVCNGSGRAKSSRTMQVRIPAGVLDGQRIRLRGKGAPGERGGPAGDLYVIVHVGSHPVFGRKGDNLTVTVPVTFVEAALGGEVKVPTLGGPPVTLKLPPGTPGGRTMRARGKGAVRKDGTRGDLLVTVEVAVPQSLGDKAREALETYREATAGEDPRAELFQAAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHZ0</accession>
    <name>A0A2G1XHZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19010</name>
        <name evidence="3" type="ORF">CYQ11_14270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50845">
        <property type="protein sequence ID" value="PHQ50845"/>
        <property type="gene ID" value="BLA24_19010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13897">
        <property type="protein sequence ID" value="PPT13897"/>
        <property type="gene ID" value="CYQ11_14270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="100" mass="9868" checksum="F13376973D42E61E" modified="2018-01-31" version="1">MTGVPTPLVAASGLVGGYAVARWTRKRPLGGVALAAAGAVAARQWRDVAGSGAAASLTGLYVAAFAGSHPLAKKIGAWPSVFAVAGGVALASWAVERRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIE8</accession>
    <name>A0A2G1XIE8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein BLA24_14555</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14555</name>
        <name evidence="3" type="ORF">CYQ11_13520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51006">
        <property type="protein sequence ID" value="PHQ51006"/>
        <property type="gene ID" value="BLA24_14555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13772">
        <property type="protein sequence ID" value="PPT13772"/>
        <property type="gene ID" value="CYQ11_13520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="162" mass="17978" checksum="30C64AD9D5AA8656" modified="2018-01-31" version="1">MADSSFDIVSKVERQEVDNALNQAAKEISQRYDFKGVGASIAWSGEKIEMRANAEERVKAVLDIFETKLVKRGISLKSLDAGEPQASGKEYKIFASIEEGISQENAKKVAKIIRDEGPKGVKAQVQGDELRVSSKSRDDLQAVQQLLKGKDLDFAIQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIR4</accession>
    <name>A0A2G1XIR4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15045</name>
        <name evidence="4" type="ORF">CYQ11_13025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51090">
        <property type="protein sequence ID" value="PHQ51090"/>
        <property type="gene ID" value="BLA24_15045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13687">
        <property type="protein sequence ID" value="PPT13687"/>
        <property type="gene ID" value="CYQ11_13025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="303" mass="32376" checksum="1D40F08A05CC1041" modified="2018-01-31" version="1">MIEARHLRVLRAVATTGSFSAAARELGCTQPAVSQQMKALEQSTGTPLLIRTGREMRLTEAGEALVRHATGILAGLTAAEEEIAAIAGLRAGRVRLVSFPSGSSTLVPTALAEMRAAHPGTRVSLVEAEPPRSVEMLREGECEIALAFRYPDVRGADPAAAAEWDDLVVRPLLTDRLIGVVPEGHRLAGAERIGIAELEREPWIAGCPRCRRHLVEVCESAGFTPRIDFATDDYPAVFGLVGAGLGVAVMPELALESVRPKGARTVPVEPVVQREIVALTLPDLARVPAVAAMLDRLEETARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIT0</accession>
    <name>A0A2G1XIT0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ORF">BLA24_14815</name>
        <name evidence="14" type="ORF">CYQ11_13255</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51049">
        <property type="protein sequence ID" value="PHQ51049"/>
        <property type="gene ID" value="BLA24_14815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13728">
        <property type="protein sequence ID" value="PPT13728"/>
        <property type="gene ID" value="CYQ11_13255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="437" mass="47495" checksum="33C60E9575756354" modified="2018-01-31" version="1">MLTAFARAFKTPDLRKKLLFTLGIMVLFRLGAHVPVPGVDYRNVQTCMDQSKSGQGLFGLVNMFSGGALLQITIFALGIMPYITASIILQLLTVVIPRLEALKKEGQSGQAKITQYTRYLTVALAVLQGTGLVATARSGALFGGCSVGNQIVPNQSIFTTVVMVITMTAGTSLIMWLGELITDRGIGNGMSILMFTSIAAGFPGALWAIKLQGKLMGGWLEFGLVILCGLAMVALVVFVEQAQRRIPVQYAKRMIGRRSYGGTSTYIPLKVNQAGVIPVIFASSLLYIPALLVQFTGSKAGWANWVQSNLVKGDHPIYMVTYFLLIVFFAFFYVAISFNPEEVADNMKKYGGFIPGIRAGRPTAEYLSYVLNRITWPGSLYLGLIALVPTVALVTLNANQNFPFGGTSILIIVGVGLETVKQIESQLQQRNYEGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIW0</accession>
    <name>A0A2G1XIW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15645</name>
        <name evidence="3" type="ORF">CYQ11_12430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51188">
        <property type="protein sequence ID" value="PHQ51188"/>
        <property type="gene ID" value="BLA24_15645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13588">
        <property type="protein sequence ID" value="PPT13588"/>
        <property type="gene ID" value="CYQ11_12430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="29180" checksum="2C760DEBCC1D20BD" modified="2018-01-31" version="1">MTTDAKDILVLGGTGKTGRRLVRVLRAAGETVRAASRSGEVRFDWNEPETWRPALAGASAVYLVAPDDPAPVADFVALAVASGVGRFVALSGRGIEQVGPGFGEGMAAAEQAVRASGAAWTILRPNNFHQNFDEDLWHGPLRDGRLALPIGEVPEPFVDADDVAEVAAAVLTGDDHDGQVYELSGPRALTFAQAVEVIARAAGRPMRYEEISAEAYAAQLRAAGTPESFVVALGALFAMHREGHSAELADGVRRVLGREPRDLADYAARAAAAGAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIZ7</accession>
    <name>A0A2G1XIZ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15835</name>
        <name evidence="4" type="ORF">CYQ11_12240</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51224">
        <property type="protein sequence ID" value="PHQ51224"/>
        <property type="gene ID" value="BLA24_15835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13552">
        <property type="protein sequence ID" value="PPT13552"/>
        <property type="gene ID" value="CYQ11_12240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="622" mass="63578" checksum="B37DE4568FA82C97" modified="2018-01-31" version="1">MSQPPKPPQPPQGPPVPPGGGFGAPQDPPPGFGAPPPAAPPQAPTPTQVSPAVQPGYGYPQTPPPPGAAPQTPPPPAGPPQTPPPPPGAPAAPAGYGYPAQPPAPDMATQAFGAATPPPAPGPYGAYPPPQYPGGPYPGAPTPGGPGGGAAKKRMAVIVSAAVALVLVVGGGVWFATKGGDDKKSEAKNSSGTGAKGGAQGGGGEVKAPQTIDAKLLFSVDQPKVDDLITVKGQWATDQVYAKADVYKVVGYGLSGGQKWEIPLDGEICWSSKQTTSDGKTAVLVKAGKPDAEHKYGGPCSQVVALDLNSGKKLWQKTAKAGDQDIRFDEVTVGGGTVAAGGTSGGAAWSLADGKELWKPKPGDDCRDDGYGGGGKLVAVRRCGDYSRPQMQVQTVNPATGAIQSAYKVPPGLNYVHVASTDPLVIAVDAGDSTGSAASDFLVIDDSAKEGKLRSKISTENGKFTPKCPSTEVEGCFKLAISKDTLYLPSEEHQSGNAQQVGRVNEIVGFDLATGQSKGKADGMAGSELVPLGLDKDGYPIGYQEPTYKAGGQVVRVDPKTFKTDVLMRNPAATAESERRISPTIHQGLWAQNRLFLSANYANKPSSFSLGKEYLAMAFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ90</accession>
    <name>A0A2G1XJ90_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">BLA24_16435</name>
        <name evidence="10" type="ORF">CYQ11_11640</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51324">
        <property type="protein sequence ID" value="PHQ51324"/>
        <property type="gene ID" value="BLA24_16435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13450">
        <property type="protein sequence ID" value="PPT13450"/>
        <property type="gene ID" value="CYQ11_11640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="242"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="350"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="484" mass="52275" checksum="7E7FCAC452EDA46B" modified="2018-01-31" version="1">MTTTTGQDFKVADLSLAAFGRKEITLAEHEMPGLMSIRKEYAEAQPLAGARITGSLHMTVQTAVLIETLVALGAQVRWASCNIFSTQDHAAAAIAVGPNGTPDDPQGIPVFAWKGETLEEYWWCTEQALTWPGTPTGGPNMILDDGGDATLLVHKGVEFEKAGAAPDPATADSEEYAQILTLLNRTLTENPQKWTQLASEIRGVTEETTTGVHRLYEMQQAGTLLFPAINVNDAVTKSKFDNKYGCRHSLIDGINRATDVLIGGKVAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQAAMDGFQVTTLDDVVGIADIFVTTTGNKDIIMASDMAKMKHQAIVGNIGHFDNEIDMAGLAKVPGIVKDEVKPQVHTWTFPDGKTIIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPEAYPTDVYVLPKHLDEKVARLHLDSLGVKLTTLRPEQAAYIGVQVEGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ94</accession>
    <name>A0A2G1XJ94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16270</name>
        <name evidence="2" type="ORF">CYQ11_11805</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51295">
        <property type="protein sequence ID" value="PHQ51295"/>
        <property type="gene ID" value="BLA24_16270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13479">
        <property type="protein sequence ID" value="PPT13479"/>
        <property type="gene ID" value="CYQ11_11805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23979" checksum="69811017B638E97A" modified="2018-01-31" version="1">MPAQHNIDVERELWDTYAESTKGDVFDAEPVFRWTQYADHGPGTELLGTPASVLEIGCGTGRALAHLARQGVKATGLDLSPVMTANTTERWGPLGARFVCGEVLEHLRSSTETYDAVYSIFGAVWFTDPVKLFPLVAERLNPGGVLVFSQPPAIPGAYGPQGMYKGGFAGKAMYTYRYSYTPRKWENLLLQAGFEKAEAQVLDAPEPDHIGTLIARAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJF2</accession>
    <name>A0A2G1XJF2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14180</name>
        <name evidence="3" type="ORF">CYQ11_13895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51330">
        <property type="protein sequence ID" value="PHQ51330"/>
        <property type="gene ID" value="BLA24_14180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16546">
        <property type="protein sequence ID" value="PPT16546"/>
        <property type="gene ID" value="CYQ11_13895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="341" mass="35060" checksum="4276A0A021F0F95D" modified="2018-01-31" version="1">MTTPSATRAISGGTTTKAVLFHELGGPEVLRVEDVPLVGPGPGEVAVRVEAVGLNRAEALFRSGTYYYQPTLPGSRLGYEAAGVVEAVGEGVSAFAPGDAVMAAANFDFGVHGVYGERVVLPQESVVRGPDGADAVTAAAMWLTYSTAYGGMVETGGLAPGDHVVITSASSGVGTAAIQTALRVGAVPIAVTRGEAKRAGLLDLGAEHVITTDSQDLVKEVKRITGGQGARLAFDAVGGPRFAALGDALTPGGTTVIYGTLDRRPAQLSLNWPLTVHAYSNGALSRQEGFRRRAGAFIGSGLASGALKPVIAETFDGLERITDAHRLMESNSHLGKIVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJU1</accession>
    <name>A0A2G1XJU1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13420</name>
        <name evidence="3" type="ORF">CYQ11_01140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51503">
        <property type="protein sequence ID" value="PHQ51503"/>
        <property type="gene ID" value="BLA24_13420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11685">
        <property type="protein sequence ID" value="PPT11685"/>
        <property type="gene ID" value="CYQ11_01140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13689" checksum="3B2EDCF8BC73A7A1" modified="2018-01-31" version="1">MRIGELAERTGVSERSLRYYEKQGLLAAERTPGGHRAYGEWAVDRVIRIQALFAAGLNSAKIAVLLPCMRDADGGPSARATGRLVAELTEERRRIDGLITDLLLSRDVLDEAIGAASLSRREPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKI4</accession>
    <name>A0A2G1XKI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11750</name>
        <name evidence="3" type="ORF">CYQ11_02990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51753">
        <property type="protein sequence ID" value="PHQ51753"/>
        <property type="gene ID" value="BLA24_11750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12001">
        <property type="protein sequence ID" value="PPT12001"/>
        <property type="gene ID" value="CYQ11_02990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="19098" checksum="BE58996BABD154DF" modified="2018-01-31" version="1">MAHETDAGGGDGTAGGAGIATAEQAANDGLVLAFGRLQGAANRLEYILGRAIEEECGISHLMFEVLLILGRAGEAGLPMRSIAQERVLSTGGVTRLVDRMEAAGLVVRDTDPDDRRGRLVRLTAVGEETVVRAARVHRENIRRFFLEPLPPEHRERFAEDLRTLSHAARDALPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKK4</accession>
    <name>A0A2G1XKK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11930</name>
        <name evidence="2" type="ORF">CYQ11_03170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51784">
        <property type="protein sequence ID" value="PHQ51784"/>
        <property type="gene ID" value="BLA24_11930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12031">
        <property type="protein sequence ID" value="PPT12031"/>
        <property type="gene ID" value="CYQ11_03170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="20915" checksum="C89A159D1E0024BE" modified="2018-01-31" version="1">MTLRVILISPASGSALREVRFDDDGPLEEAGLRGARAVAGTLPRASLVLTAPSTRCRLTASALGLDPRVAPELRDLDAGSWRGRTLDEVFAAEPEAVAAWLADPGAAPHGGESVTELVGRAGAWLDERSGDAGRVLAVAEPAVVRAVLVHALGLPPAAFWRLDVPPLTATELTGRAGRWNLRCGRPLTGAATPEEPTTGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL8</accession>
    <name>A0A2G1XKL8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11825</name>
        <name evidence="3" type="ORF">CYQ11_03065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51766">
        <property type="protein sequence ID" value="PHQ51766"/>
        <property type="gene ID" value="BLA24_11825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12013">
        <property type="protein sequence ID" value="PPT12013"/>
        <property type="gene ID" value="CYQ11_03065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="73"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="49807" checksum="D8FD6CB017D481D8" modified="2018-01-31" version="1">MHSARASVIFRGLRKDTLPVIRRRRGARRESPFRVRGVACQQGRREGTLFPDVVGRGAEEIAVTLRRTDDLCIGAVVPRTGRLARLGDPLAFALERLAPRLARPGRGNRRRTFRLAWRDSQSDPDGARRAVAELVRDEGARMVVTLGGTRVLPAVADACEVLGIPCLSTGFPWQAYVFGRGGDPARPFRWTYHFAWGLDDIATVFAELWEHLGPGRTVGCLWNTGPQGQLLRDPRHGFAPVAAARGHTLVDPGGYREPATCFEGHVHRFKEAGVEVVTGAATAGDMALFHRQAREAGLRPRLITCSRWLTHPGEGGVPDGLAEADVATLVYWTPRHPFRSSLDGTTTAGLAEEYQRTTGRPWLQPLGLAHALLEVAAHALATADDPMDRHAVAAALGRTRLATVAGLLDFTAGPTPNIALVPLIGGQWRSGRRRGHELTLVTNARLPKVAPNAELSVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKM7</accession>
    <name>A0A2G1XKM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3291 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11910</name>
        <name evidence="4" type="ORF">CYQ11_03150</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51780">
        <property type="protein sequence ID" value="PHQ51780"/>
        <property type="gene ID" value="BLA24_11910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12027">
        <property type="protein sequence ID" value="PPT12027"/>
        <property type="gene ID" value="CYQ11_03150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="2">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="192" mass="21084" checksum="85649F6B189D5583" modified="2018-01-31" version="1">MPHLALYTFGVLKSPLADPARLTQEFYESGEAVYREIGQHPGYIAHAEPAEHSRGALFGSDWGAWGEFAVPAWYGKGRTAETTALAATLSLWTDLGSAIDAVYTGLHRVALNRRHDWFERTGHPSHVSWWVADGAIPTWQDGVTRLEHLHDHGYAPHAFTFHHSFDPAGTPARLKGIGPKGDMSVPDSPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKY4</accession>
    <name>A0A2G1XKY4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_11210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000134">
        <property type="protein sequence ID" value="PHQ51876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51876">
        <property type="protein sequence ID" value="PHQ51876"/>
        <property type="gene ID" value="BLA24_11210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="4">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="221" mass="24316" checksum="9B009EA54FF0D92C" modified="2018-01-31" version="1">MVNRAVLAHRLFTGLSRRHFACLVEELAVPWQAGLGGRRHAARGGARKRAAGAGARHQLVFVDRLVATLIHLRHDLPHAVLALLFGVDRSTVTRAIGEIRILLAERGCAVPDRPGLRLRTLADVFAYAHAEDIELRLDATEIQVRRPPAGRGGWCAFVSGKKKQNTMKATVIADWRGRTLWTDSLRPGRMHDATAARTEGIAVCFQHFPDVEVSWTTATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL86</accession>
    <name>A0A2G1XL86_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_10850</name>
        <name evidence="6" type="ORF">CYQ11_00700</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51941">
        <property type="protein sequence ID" value="PHQ51941"/>
        <property type="gene ID" value="BLA24_10850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11615">
        <property type="protein sequence ID" value="PPT11615"/>
        <property type="gene ID" value="CYQ11_00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="132"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="445"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="547" mass="57770" checksum="DA64FF1340EB6A00" modified="2018-01-31" version="1">MAEDSSGPIGLSSAPENGRPTRARTESRCARRRPGSVLTGVAAGTAALVFLAAPGPAPSSAASPLPGEPRPAVPSRYVPAPCPAPPQPIAALRTARCGFLEAPENRSRPGRRTVRLAVAVIPAKSARPAADPVVFMAGGPGGDAFDDIPFLVDSGLNKDRELIVMAQRGNLYSQPNLACPEMDRFNAQAVGLRYGARSTERLLLRAVKECRDRLTAGGVDLSAYNTAENAADFADLRKALGIAQWDVYGYSYGTDLALTYLRRHPDGIRAVALDSLTPPRTATLPWTWSSAQEGIGTIFEACAAEPRCKNRYPDPALTLTQQVRRLEAQPLTLDASPPSGGKPVKVVLDGGALLDLLVGNALPAKDVPAALEELSHGHPERFAQARAAGSVQDVGAFAHGLTQSVACSEWAPGYSESDVLKAGRRAFPGWPDTVLAQPPQLPFQYAACRVWDVPNRASSQRVATVSSVPALVVSGTFDTKTGASWARDAARNLSRSTAVRIPGIGHWVVPQSPCAQRVLASFLARPTAPDTGCADGLKPQPFTITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL92</accession>
    <name>A0A2G1XL92_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000118">
        <property type="protein sequence ID" value="PHQ51986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51986">
        <property type="protein sequence ID" value="PHQ51986"/>
        <property type="gene ID" value="BLA24_10395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="111" mass="11361" checksum="C152FE98240DBBAC" modified="2018-01-31" version="1" fragment="single">LAGSAGGPRPRTLPRSALYRALRDEATRRGIPVEYGKRLVATGTGPRGTVTALFADGSRAEGDLVVGADGIHSRTRTLLDPPRPAPATPASSPSAAAPATPATRRPRTPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLD5</accession>
    <name>A0A2G1XLD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000099">
        <property type="protein sequence ID" value="PHQ52058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52058">
        <property type="protein sequence ID" value="PHQ52058"/>
        <property type="gene ID" value="BLA24_09710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="123" mass="13083" checksum="CEBE6C462D36B79E" modified="2018-01-31" version="1">MSLDGDCDDAGEGVADPSDLVLLALRPRQCVAADGLSALEAVQDVGRVSSATATVRSWRERRRRRTVRVVKATTATTSRRAAPLAATSRTTWSSSCAARSSAWASSSFSSLSSRVSNWPEKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLG0</accession>
    <name>A0A2G1XLG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_09110</name>
        <name evidence="5" type="ORF">CYQ11_27720</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52075">
        <property type="protein sequence ID" value="PHQ52075"/>
        <property type="gene ID" value="BLA24_09110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16155">
        <property type="protein sequence ID" value="PPT16155"/>
        <property type="gene ID" value="CYQ11_27720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="33"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="383" mass="38737" checksum="281E70B1AC3D26FF" modified="2018-01-31" version="1">MPQDPFDWIDAQHERLRAAGLVRTLRPRSAGADLVDLAGNDYLGLTRHAEVVEGAAEAARRWGAGATGSRLVTGSTALHATLERELADFCGFEAALVFSSGYAANLAAVTALSGPVGSGTLLVSDEGNHASLIDGCRLARADKAVVPHADPEAVRKTLAAHGGRALAVTDSVFSVDGDAAPLAALAGVCREHGAALLVDDAHGLGVLGRGGRGALHAAGLAGARDVVATVTLSKSLGSQGGALLGPARVISHLVSTARTFIFDTGLAPAAAGAALASLAVLRREPGRAERVRAVATGLYERLTAAGLTAVRPDAAVVSVRAPSPEAAVRWAADCRERGLAVGCFRPPSVPDGVSRLRLTARADLSDEQLAGAAATIVATAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLK6</accession>
    <name>A0A2G1XLK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-aspartyl-peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Isoaspartyl peptidase/L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_09395</name>
        <name evidence="7" type="ORF">CYQ11_28005</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52125">
        <property type="protein sequence ID" value="PHQ52125"/>
        <property type="gene ID" value="BLA24_09395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16205">
        <property type="protein sequence ID" value="PPT16205"/>
        <property type="gene ID" value="CYQ11_28005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304949" evidence="5">
        <location>
            <begin position="37"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="362" mass="37438" checksum="8DF6707DDFA43F09" modified="2018-01-31" version="1">MRPLSRPWTVPALALLVAAAAALPGLPQRPAGHAQAAAATAARTATDGGPRPEAHDVVLAVHGGAGSALRREDTDARTERAYRDGLADALRAGQRVLRRGGDSVSAVEEAVRALEDNPLFNAGKGAVFTEDAGHELDASIMRGSDLRAGAVTGVRHVRNPVSAARLVMERTPHVLLAGEAADTFAVRQGLTPVTQDYFWTQQRWDELMRAKKARSGDGRRDAVVTGTVGAVAVDASRSLAAATSTGGMTNKMAGRVGDSPVVGAGTYAKNGNVAVSATGQGEVFLRGAAAATISHLVEFGGRDLAAAAYEVVVERLPRLGGKGGVIALDDRGTYAAPRSSDGMLHGYATADGRIVTKVFPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM8</accession>
    <name>A0A2G1XLM8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07880</name>
        <name evidence="2" type="ORF">BLA24_10000</name>
        <name evidence="4" type="ORF">CYQ11_00315</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000104">
        <property type="protein sequence ID" value="PHQ52029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52029">
        <property type="protein sequence ID" value="PHQ52029"/>
        <property type="gene ID" value="BLA24_10000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52361">
        <property type="protein sequence ID" value="PHQ52361"/>
        <property type="gene ID" value="BLA24_07880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11563">
        <property type="protein sequence ID" value="PPT11563"/>
        <property type="gene ID" value="CYQ11_00315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="19028" checksum="D449B4F46B78FBBA" modified="2018-01-31" version="1">MDHLSSASPTVVRLTRYTKTEQTEILGDGADPFGVADTGLTWLPKEDHFGVKLDGRLVAHTGLLRVPISIGAVETEVVGVGGVAVAPDVRGRGLARKVLAAALEHARTMGPRHGLLFCRPPLVPLYQRLGWRVLNQDVHVEQHEGPVIMPLASMWTPLHGDADWPAGAVRLLSFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLW7</accession>
    <name>A0A2G1XLW7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52171">
        <property type="protein sequence ID" value="PHQ52171"/>
        <property type="gene ID" value="BLA24_09660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="40"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="263" mass="28262" checksum="0991C48FB7DCB25E" modified="2018-01-31" version="1">MAGPAPSAPHHAGPHRTRCPPRGAARVPHGDEEALPEPLPFREFVTQARLGVSREEHERYFAALLGDVTETTAPYGLLDVHGDGSASVRARMRVEDALAQRVREAARSWGVSPATVFHLAWARVLATVSGRDDVVFGTVLFGRMNAGAGADRIPGLFMNTLPVRVHVDGTGVGDALRSMRSLLAELVAHEHVPLTLVQAAAVCPAAARCSPRSSTTGTAPRPDPSRTTWTTCSKASRPSTPVSTRTSLWTSPWTSTRRVHDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLW9</accession>
    <name>A0A2G1XLW9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_08635</name>
        <name evidence="5" type="ORF">CYQ11_03890</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52223">
        <property type="protein sequence ID" value="PHQ52223"/>
        <property type="gene ID" value="BLA24_08635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12156">
        <property type="protein sequence ID" value="PPT12156"/>
        <property type="gene ID" value="CYQ11_03890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="2">
        <location>
            <begin position="70"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Lant_dehydr_C" evidence="3">
        <location>
            <begin position="803"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1078" mass="116062" checksum="86951FBE4E0AEF3D" modified="2018-01-31" version="1">MSVTRRNAETSDRKSGRDRTYVARDFFLLRAPALPTRGMTDLLAAGARTPGADPAGWEARYLRGLLEMWARPGVRSAISLAAPDLARAVEGVDALSARDRRRAMMSLGRYLNRMSMRPTPLSTVAGVAVGAFPGPAPAAPPGRPDTPAGTLLGVPAIVDAVARPDMGWVLHLFKSVIDAPRARPELELRTNDLIHRSRGRAWLSTADAYGEGSRRSVSVRWSPAVGLVLESARTPKTFGALRDELTQRYPAVPPEKVTALLDQLVELAFLITAHRPVLLEGAEQPPLSARLATACDDEAVAALASVEDAVAAFNAAGDVAALEALQEEIAPSARQVSADYGGPLLRVDARLNVPARPVLPAEVQTLAEDAAGILTTVGDVYQYPLRLRDYATAFTERYGAQAEVPVLEVLSEETGLGPPAGYLNPPRSFELQPTTTSDRSRQDRDAVLQRFAADAISRGGLEAVLDERWTAELRQHDDRPLRPAIDVHLQLAPPTAPGSGWHGVVTAVAYGGRTFARFHDVLGEEGRRDLAELAAAEAALLPGVAVVELTYLPEKARATNVAVRPAVRTLELPLNVAPGRPAHQVIALEDVVVGVRQGRLYLHSPVLGCDLHVTQHTMLNPLMAPNVGRFLLDVSSAAFRDVSPFDWGSLTNSMPFLPRVVWRDLVLRRARWLLSASGLPASCTGSPAAFTAAVTAWRAQWNVPRHTVLTQGDNTILLDLESAPSLEELRLAAARDADFTLRIEEALPGPEEGFLRDEAGAPFAAEVVVPVLRRQPAPAPRAVAAARRPVTDAERLRPVGGPWVYAKLYVENDAQDALLVEEVTALTRSLAERRLAGHPFYLRYGDPAPHLRLRFPAADPARAAELLGEVATWGHGLVVGGRIVDVSFATYRREVERYGGPELIDAAEELFRADSAATLALLRHLAAPAPAGEVPLDRAALTVLSLEAVGRSLVPDFAERHDLVRSMAGPRAGGAEYRAVARRLWQGHTAPGAEAAVLGQVSEAWRDAGAGYAARVAELAAAGALWSDREDILRSLFHMHSNRMGLRREQEDAAYGMWRRLLDRVAAAGDAPAAGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY2</accession>
    <name>A0A2G1XLY2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">CPBP family intramembrane metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_08945</name>
        <name evidence="3" type="ORF">BLA24_09890</name>
        <name evidence="5" type="ORF">CYQ11_04200</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52052">
        <property type="protein sequence ID" value="PHQ52052"/>
        <property type="gene ID" value="BLA24_09890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52274">
        <property type="protein sequence ID" value="PHQ52274"/>
        <property type="gene ID" value="BLA24_08945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12206">
        <property type="protein sequence ID" value="PPT12206"/>
        <property type="gene ID" value="CYQ11_04200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="283" mass="29382" checksum="935D2FE8F1F7F1D7" modified="2018-01-31" version="1">MTSGREATVRQDAQGIGGGTETAADGGPPAGDGLSRRTLRTEMLLVLALSLGASAVSSLISFIGSLTRPGGLKHQAATLNASHAPGRPWLDLAWQVFGIATALVPVLLVAHLLTREGAGMRSIGFDRTRPGPDVARGALVAAAIGGTGLLFYLAARAAGFNLTVVPENLPDVWWRIPVLIGSAVQNAVLEEVVVVGYLLRRLGQLGWTPTAALAASALLRGSYHLYQGVGGLIGNMVMGVVFVLLYRRWGRVGPLVAAHALIDTVAFVGYALLAGKVGWLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM57</accession>
    <name>A0A2G1XM57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08875</name>
        <name evidence="3" type="ORF">CYQ11_04130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52261">
        <property type="protein sequence ID" value="PHQ52261"/>
        <property type="gene ID" value="BLA24_08875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12193">
        <property type="protein sequence ID" value="PPT12193"/>
        <property type="gene ID" value="CYQ11_04130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="18418" checksum="ED2D2833BCD0922D" modified="2018-01-31" version="1">MTGTQRRGRGAMMSPAELDAFLTGQRTCRAATTGRDGRPHVSALWFAWDGRALWLYSLTRSRRWADLRHDPRLAVVVDDGLAYGELRGAELSGAVAFVGEVPRTGEPCPELAAPERLFAAKYFGAGDLPHDGRHAWLRLVPESVVSWDFRKLALPPGARAERPRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMC6</accession>
    <name>A0A2G1XMC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06455</name>
        <name evidence="4" type="ORF">CYQ11_26605</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52424">
        <property type="protein sequence ID" value="PHQ52424"/>
        <property type="gene ID" value="BLA24_06455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15956">
        <property type="protein sequence ID" value="PPT15956"/>
        <property type="gene ID" value="CYQ11_26605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="28168" checksum="C483133CA189FECD" modified="2018-01-31" version="1">MTDTTGQEYETILVERKGRTALVTLNRPKALNALNLQVMNEVVAATEALDRDPDVGCVVLTGSERAFAAGADIKEMRPRSYMDMYLSDWFTAWDRLGQLRTPTVAAVSGYALGGGCELAMLCDILLAADTAVFGQPEIKLGVIPGIGGSQRLTRAVGKAKAMELCLTGRTMDAAEAERAGLVSRIVPAAELLPEALAVAETVAGMSAPVAMMAKEAVNRAFETTLAEGVRFERRLFHAVFATADQKEGMSAFVDKRPPEFTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XME4</accession>
    <name>A0A2G1XME4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000088">
        <property type="protein sequence ID" value="PHQ52309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52309">
        <property type="protein sequence ID" value="PHQ52309"/>
        <property type="gene ID" value="BLA24_08305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="103" mass="11117" checksum="95D639395C3F4E03" modified="2018-01-31" version="1">MDGELQVLGVFEGLFELALRCFQLFGQSVEHRAYQPALGVDVVVVLAQRVELRHGLVGRFALLRVVQLGGYLVVYTSPGSAGPTADISPPVSSLLELRALEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMG0</accession>
    <name>A0A2G1XMG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_08035</name>
        <name evidence="7" type="ORF">CYQ11_00475</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52418">
        <property type="protein sequence ID" value="PHQ52418"/>
        <property type="gene ID" value="BLA24_08035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16262">
        <property type="protein sequence ID" value="PPT16262"/>
        <property type="gene ID" value="CYQ11_00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="201"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="50707" checksum="B55801F050C13319" modified="2018-01-31" version="1">MRIAFLLNNAYAIGGTTRTTFNLAASLAERHDVRLVSVFRHRAAPLLEAPPEVPLTALVDRRQGTADMADPRTRQPGVHFPAGDSRASLYHRLAEQRIIDWLAETDADAVISTRTGLNVLLARFGPRDALRIGQEHLTHDTHPHRLRRELQRWYPHLDALVTMTRADARAHRTGLRLPYEMIEAIPNSVPATTLPPADCTAKVVVAAGRLTRVKRYHMLIEAFARISAQRPDWTLRIYGGGPEKDRLAADIDRRGLHDRVRLMGAVTPLDPEWANGSIAAVTSAQESFGMTITEAMRCGLPVVSTDCPHGPREIIRDGVDGLLVPRDDVHAYSAALLRLMDDQQLRTRMGAAARERVASAFAPQDAARRYDELLTALRARRSSLPSDTPGLREGPRLLGAAALYRATGALLAHGALRRLRRLRRTPLGARVGAKRRHVQWSFALFAAVATLVFLAGVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMG8</accession>
    <name>A0A2G1XMG8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ORF">BLA24_06480</name>
        <name evidence="14" type="ORF">CYQ11_26630</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52428">
        <property type="protein sequence ID" value="PHQ52428"/>
        <property type="gene ID" value="BLA24_06480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15960">
        <property type="protein sequence ID" value="PPT15960"/>
        <property type="gene ID" value="CYQ11_26630"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="13"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="441"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ52428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="774" mass="83136" checksum="E31C4011716179A5" modified="2018-01-31" version="1">MTSTTAAAAARATVYGYPRQGQGRELKKAVEGYWKGTVTAAALRDTAAGLRRATWRQLAGAGVHEVPTGDFSYYDHVLDTSVMVGAVPARHRAAVEADALDGYFAMARGTQEVAPLEMTKWFDTNYHYLVPELGPDTVFTADSAKQVGELGEALALGLAARPVLVGPVTYLLLAKPAPGVAEGFEPLTLLDRLLPVYAEVLADLRAAGAEWVQLDEPALVQDRTPAELNAAARAYRDLGRLTDRPKLLVASYFDRLGEALPVLAKAPVDGLALDFTRAAAANLAALAAVGGLPGKRLVAGVVDGRNVWIDDFEQSLSILGTLLGLADRVDVAASCSLLHVPLDATAERDLDPQVARWLAFARQKTTEVVTLARGLAQGTDTIAAELAANRADLASRAGSALTRDPAVRARAAAVTAADARRSQPYPERTAAQRAHLGLPPLPTTTIGSFPQTGELRAARAGLRAGRLDEAAYEQRVEAEIREVVAFQEKAGIDVLVHGEPERNDMVQYFAEQLTGYLATQHGWVQSYGTRYVRPPILAGDVSRPEPMTLRWTRYAQSLTRRPVKGMLTGPVTMLAWSFVRDDQPLADTARQVALALRDEVDDLEAAGTAVIQVDEPALRETLPLREADRPAYLAWATEAFRLATAGVRPDTQIHTHMCYAEFGDILTAIDDLDADVVSLEAARSHMQVAGELAGAGYPREVGPGVYDIHSPRVPDAREAASLLRTGLKAIPAERLWVNPDCGLKTRAWPEVRASLENLVAAAREVRGELPGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMK0</accession>
    <name>A0A2G1XMK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52433">
        <property type="protein sequence ID" value="PHQ52433"/>
        <property type="gene ID" value="BLA24_06515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="83" mass="8541" checksum="2EB18D9D408D97B7" modified="2018-01-31" version="1">MRRPPPGGGRTGQALPGGAGGPAPRTRRTMTVLRPGSSCASPAPAWARPVRDRARHPSAQHHVPSPSPSPSPSPSPWSRATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMM4</accession>
    <name>A0A2G1XMM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06885</name>
        <name evidence="4" type="ORF">CYQ11_27035</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52497">
        <property type="protein sequence ID" value="PHQ52497"/>
        <property type="gene ID" value="BLA24_06885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16031">
        <property type="protein sequence ID" value="PPT16031"/>
        <property type="gene ID" value="CYQ11_27035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="208" mass="22463" checksum="32A318201F921F37" modified="2018-01-31" version="1">MVVSGDEYGAWRNHFIALLDRLPIPIAICHANGEVTVANPAMATEWGMAPGQVRGRNLLELFRPRAAEQIERLTEALRLGNRSRYTIDVCWPAGHGDALREGELLVDPVGEPTRTYPMLLAVLRVREAPEPAPVVGVSEVEGRILALAAAGSTTAAIGKAVGLTVDGVNYHLGRLSRRWRVPNRTALVAKAYVLGVLVPGRWPPEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMV9</accession>
    <name>A0A2G1XMV9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07380</name>
        <name evidence="4" type="ORF">CYQ11_27535</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52582">
        <property type="protein sequence ID" value="PHQ52582"/>
        <property type="gene ID" value="BLA24_07380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16120">
        <property type="protein sequence ID" value="PPT16120"/>
        <property type="gene ID" value="CYQ11_27535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="205" mass="22645" checksum="714323919B6BF1A6" modified="2018-01-31" version="1">MSPRSAAVNEELRRRSCERLLQATVELVGERGYEATTLADIADRAGAARGLVSYYFPGKRQLLQSAVHRLMHRELASFLGREPLTEDGHELLARAIDAVLGLARERPLLMRTHMAHILTAEGFIQCPEQQRLAFLLRDTVARYGSPDPDTDYRLLRALLMGAVVAILLPGAPMPAERLRAELFQRYGLAWELGVPPAAEPAAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMY5</accession>
    <name>A0A2G1XMY5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06660</name>
        <name evidence="2" type="ORF">CYQ11_26810</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52612">
        <property type="protein sequence ID" value="PHQ52612"/>
        <property type="gene ID" value="BLA24_06660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16823">
        <property type="protein sequence ID" value="PPT16823"/>
        <property type="gene ID" value="CYQ11_26810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="384" mass="42239" checksum="2C4A9F45475107AE" modified="2018-01-31" version="1">MPLSARDHAAEGARPGRRRVLFAPVPITPTKPLTPSHIKGLLWADVISRATAVLADVDHLHSHTVAVANAQTLGFWAHLDAHHPGLDFSGLDEEHIGSLYVEFQRRRDGGAFGDLSAYHEAVARDGWLHPASSRVLDLWTRRWAELGMRDPGLTARRPPPATADEVLDLLARRGLCIDHRPSGGPVYLDATRHGLPLRQIMSAGRHANYLLGLLRELAPLVGSYDSVVLACDREAVPDYTLLAKVLTDLGAAVTLVGIGRVRLGGDLKSSRHGGWEGRTAAHLAEEFLPRVGPAIYRLGVRLYYIAVLGQGDREPFRPQLLWRCMARAKRLLDRPATGTGADLPEFLARHARPHPHVDPYRLTTALLTRNRPAPGRELLEKVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN10</accession>
    <name>A0A2G1XN10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ROK family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07505</name>
        <name evidence="4" type="ORF">CYQ11_27655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52606">
        <property type="protein sequence ID" value="PHQ52606"/>
        <property type="gene ID" value="BLA24_07505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16143">
        <property type="protein sequence ID" value="PPT16143"/>
        <property type="gene ID" value="CYQ11_27655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="40126" checksum="C9172404021741FD" modified="2018-01-31" version="1">MGRLTGGDPSLLRRINSAVVLHALRAAEAPTFTDLVKMTGLSRPTVEGVVEGLIGSGLVVEAAADEGAARRQGRPARRFRFRVEAGHLLGVEIGPHRIAALLADLGGRVTGSAHVEVPHTAPADERLEQVRVAVADLLARSGVPRGSLRAVGVATPGIVEADGTVRLGTALPGWTGLRLGERLRRSFRCPVLVENDANAAAVAEHWKGAATGSDDVVFVLAGLSPGAGSLIGGRLHRGFGGAAGEIGALHLLGREATPEEVLSTTGEPLHPLDEAQVANVFARAGQGDARARAAVERYLRRLVHDVAALVLALDPELVVVGGWAAGPAGVLEPLRTELARYCLRPPQVAQSLLGEAAVATGALRLALDHVEEQLFAVESTVTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN36</accession>
    <name>A0A2G1XN36_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06055</name>
        <name evidence="3" type="ORF">CYQ11_03580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52665">
        <property type="protein sequence ID" value="PHQ52665"/>
        <property type="gene ID" value="BLA24_06055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12099">
        <property type="protein sequence ID" value="PPT12099"/>
        <property type="gene ID" value="CYQ11_03580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="534" mass="56471" checksum="2766E1A8672713CA" modified="2018-01-31" version="1">MNRYDAVVVGSGHNALVTAVYLARAGWSVVVLEGNDRPGGLVRTDEVTVPGFRHDVYSSAHPLFTSGPAYAELGPELAACGLTYRDSPFSIGVSMPGAESAVFSTDAAANVAEADRLAPGDGAALAALLADFAPYAGPVFALFAADLADPGPTRIVHGLMRDDGHCSTFAQRFLRTSRDLLEHRFSSPVLRGLLAPWALHLGRGPDEANSAFWTLLTLVAVTTAGMPTPEGGSEQLARALTTLTERHGGRVETGRWVERVLVRDGLATGVRTADGEVVTAARAVVASVNPDQLYLKLLAHEDGVVPPVIRQQADEYRYGRGCVQLHLALSEPPRFEDERLTRTGLVHLTRGLDALSRSVNEAARGLLPARPTIAFDTPSTADPTRCPPGAAVARLQILDVPLRLRGDAAGEIDTRAGWTDDVKNAFADRVIGLAARHTPNLPGAIVGRHVIGPDDLARFNPNCGPGDPYGGSHELAQSYLLRPLPGQPSHRTVVPNLFMVGAATWPGHGVNGASGYIVADKLLTSGARTASRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH9</accession>
    <name>A0A2G1XNH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05970</name>
        <name evidence="3" type="ORF">CYQ11_02445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52805">
        <property type="protein sequence ID" value="PHQ52805"/>
        <property type="gene ID" value="BLA24_05970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11907">
        <property type="protein sequence ID" value="PPT11907"/>
        <property type="gene ID" value="CYQ11_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="70" mass="7773" checksum="19DAD2D13A3B89AC" modified="2018-01-31" version="1">MPNDDLKRFLAALSPASREKVQQLPQERQDQLAAAWRTELRDDTDLDALDELSPAAGASEAAERVVRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNL6</accession>
    <name>A0A2G1XNL6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05860</name>
        <name evidence="4" type="ORF">CYQ11_02335</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52828">
        <property type="protein sequence ID" value="PHQ52828"/>
        <property type="gene ID" value="BLA24_05860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16303">
        <property type="protein sequence ID" value="PPT16303"/>
        <property type="gene ID" value="CYQ11_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758419" evidence="1">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="29"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="28320" checksum="33CD50BB7DFBB1F2" modified="2018-01-31" version="1">MAAALLLFACATGPALATAAEPPAVRYVAMGDSAAAAALVPPQTSLSCLRSGENYPHLVARELHLASFADVTCSGARTTTLGPQLAALSPETTLVTLTIGANDVGIVQALALCSLLGAARPHGHPCRDTYRHDGRDGLEQRADAAGPQVGAALDAVHRRAPSALVLLVGYLDVFPAPPHGCRPRETFADGDLAHLDAVENRLDATLSRTARAHHAVFVGLHPASAGHDFCARDGVRWSEALVPTRPTAPFHPNHLGEQAMARETLTALRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN2</accession>
    <name>A0A2G1XNN2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05630</name>
        <name evidence="5" type="ORF">CYQ11_02090</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52749">
        <property type="protein sequence ID" value="PHQ52749"/>
        <property type="gene ID" value="BLA24_05630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11846">
        <property type="protein sequence ID" value="PPT11846"/>
        <property type="gene ID" value="CYQ11_02090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="749"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="843" mass="89552" checksum="C578B60940114468" modified="2018-01-31" version="1">MASEFSTLLRRLRREAGMTQEALAERAGVGVRTVRGLETGERADPRVTTVRLLADALGLAPEEREELLAAVVRRTGPGDEPDTPDDAAERVAPVAGRPGPADRVAPSAGHQGEGPADGAEPVGGYPHDGSAERVAPVAAHPGDGSAARAAPVTEPRGPVSHGTLADVAEQLAQAVAARWQREEEQRQVHDPYPLPVRWRPALEELTDHWANIRRLPAGAVPGPLDLSGRLDAIVEVYRRVPSGRLVVLGRPGSGKTVLAVRFVLEQVKSRGRTGTVPVIFSIGSWDPTAITLRDWLIAQLTRDHPGLAAPGPGGSSLAAALVETGRVLPVLDGFDEIAGGLRRPALEALNSTVLPLLLTSRPSEYAAAVAETDVLTSAAAVQLTDLTPGDLADYLPRTTRKAGGGDPAATAWDPVLRELRDRPDSRAGANLAAVLTTPLMVMLARAVYSDTSGHDPAALLDTRRFGSAEELEEHLLDKFTTTVYRPRPEHRPGGGPRRSFDPERARQWLGHLAHHLTRLDTPNLEWWRLGSGTRRSTRTLVTAVAVALTVGLVDAVVGTLFDPVGFQLADGLVAGLLAGLMFGITYWFLIASRGAAVAPSGVRLKMFGRAGGTGRRTAHRLAVGLLCGVVFGSGYGFVRGVLNGVVRHCGLLVTLRVGLDDGVVYGLVFALATGPTFGVLSLLETPLDVRSAVNPVGLLRTNCRTVVAQLLIWAPTFGLLVALGAWGAMRILPALLGPLVWNTTATLKLGLISGLGGALAYALALTGWGQWLVFGRFWLPLTGRLPWSVVTFLEDAYERGVLRQAGAVYQFRHARLQDHLARAHRTSRGSQRPAGPGGAEPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR7</accession>
    <name>A0A2G1XNR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_04750</name>
        <name evidence="7" type="ORF">CYQ11_28785</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52878">
        <property type="protein sequence ID" value="PHQ52878"/>
        <property type="gene ID" value="BLA24_04750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11463">
        <property type="protein sequence ID" value="PPT11463"/>
        <property type="gene ID" value="CYQ11_28785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="10076" checksum="357B20F870F1C5AE" modified="2018-01-31" version="1">MSGRVELDEETVERDLVRLVLTVVELLRQLMERQALRRVEQGGLTEEQEERIGLTLMLLARRTEELCGRYGLDPEDLNLDLGPLGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNY0</accession>
    <name>A0A2G1XNY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hydrogenase expression protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_05040</name>
        <name evidence="13" type="ORF">CYQ11_28490</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52920">
        <property type="protein sequence ID" value="PHQ52920"/>
        <property type="gene ID" value="BLA24_05040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11419">
        <property type="protein sequence ID" value="PPT11419"/>
        <property type="gene ID" value="CYQ11_28490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="10">
        <location>
            <begin position="29"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="11">
        <location>
            <begin position="220"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ52920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT11419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="37800" checksum="C3AED4FB2B4267E7" modified="2018-01-31" version="1">MGAPSTTTPASGTAFDEVHILWTSEGMSCDGDTVSVTAASLPSLEDVLLGAIPGVPKVHLHNKVLAYETGDDFMAAFHQAARGELEPFILVVEGSIPNENINGDGYWTAMGNDPETGEPITLNEWLDRLAHRAWAVVAIGTCAAYGGIHAMAGNPTGCMGLVDYLGADFRSAGGLPVVNVPGCPVQPDNFMETLLWVLHQAAGLAPVIPLDEQLRPTWLFGKTVHEGCDRAAYYEQGDFAKDYNSPKCQVKVGCWGPVVNCNVTKRGWMDGVGGCPNVGGICIGCTMPGFPDKFMPFMDEPPGGSLSSGLMSVYGPLVRSLRSVTNSAANREPKWRHNRDALTSGYEPRWGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP31</accession>
    <name>A0A2G1XP31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000068">
        <property type="protein sequence ID" value="PHQ52998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52998">
        <property type="protein sequence ID" value="PHQ52998"/>
        <property type="gene ID" value="BLA24_04415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013901458" evidence="2">
        <location>
            <begin position="46"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="375" mass="38231" checksum="A71E710AEADD8FF5" modified="2018-01-31" version="1">MKFRRTLATAAVMAAVGPVALLAAPGAVLTSLGPLSQLVASPAHAAEHAPAADGKPAASAAPSAAPSPIGRPGEETRPSTGPGSGTTDGSRPAPSAKPSAAPSTPSAEPSKAPQVTPSPSFSRSGSCSPIFDEDRGKTGLRGLPSKIVAGSGWHEFTYRVTNVSKVTVVEADVSLMLGTADPKLDDIAQLDVTVEWYNPATRSWKAIEGGGAGALDNYDFATVKNIKPGEYADAKMRIKAGDKAQAGTGYFFTIGHSFGADGKCGSDGISQFDFTVLTPGSKPGKVGDAKASRGSRAASSRPTRPSRPLPGTRPPPRASAPRSPSPASSRRPVRPPPCPWSRASAVPPWSRAGLRSSSSSAARATPRRNPATSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPH3</accession>
    <name>A0A2G1XPH3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIMPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03985</name>
        <name evidence="3" type="ORF">CYQ11_07330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53049">
        <property type="protein sequence ID" value="PHQ53049"/>
        <property type="gene ID" value="BLA24_03985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12721">
        <property type="protein sequence ID" value="PPT12721"/>
        <property type="gene ID" value="CYQ11_07330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="26017" checksum="779D1C0F65B9426F" modified="2018-01-31" version="1">MTTPHPAPLPYGTPDAPRVAVRGEARLEVDPEIAHLGISISARGTDRRTTLDDLTRRNNHTLELLRSYGQAIEKIETGSFTITPQLNDKGRHERVHAYHGHVHHTATVTDFTTLGELVTRLSENDLIRINGPWWSLRPDSPAHREARQKAVREAVQRAREYADALGSRLVALVELADTGAEHTLPTAPAGPPAAPGGMMRSGFGGAPPTPPPTLDLEPRRQTVHAHVNARFTMTPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPL7</accession>
    <name>A0A2G1XPL7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_02255</name>
        <name evidence="9" type="ORF">CYQ11_04615</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53184">
        <property type="protein sequence ID" value="PHQ53184"/>
        <property type="gene ID" value="BLA24_02255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12276">
        <property type="protein sequence ID" value="PPT12276"/>
        <property type="gene ID" value="CYQ11_04615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="21192" checksum="3A47EF4653920433" modified="2018-01-31" version="1">MRDDEKVTAWALAARAGDGDAVERFIRATQSDVRRYVARLSNDPQGADDLVQETFLRALRSLPRFEGRSSARTWLLSIARRTVVDRLRFQAARPRLSDTDDWLSAAERAQSAALPGFDEGVALSQLLDRLPYERREAFVLTQMLGLPYAEAAVVAGCPVGTVRSRVARAREALIGQLETAERAAAARVPALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPM8</accession>
    <name>A0A2G1XPM8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">BLA24_02355</name>
        <name evidence="15" type="ORF">CYQ11_04720</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53198">
        <property type="protein sequence ID" value="PHQ53198"/>
        <property type="gene ID" value="BLA24_02355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12290">
        <property type="protein sequence ID" value="PPT12290"/>
        <property type="gene ID" value="CYQ11_04720"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ53198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="30696" checksum="E0632F454535033B" modified="2018-01-31" version="1">MLRIAVPNKGSLSEPASAMLHEAGYRQRKDRRELVLVDAENEVEFFFLRPRDIAVYVGSGKLDIGITGRDLLLDSGSRAEEIMQLGFASSTFRYATRPGTAKDVSEFGGMTIATSFSGLVTKHLADNGVDASVVHLDGAVETAIQLGVAEVIADVVETGTTLRNAGLEIIGEPILKSEAVVIRRVGAPADDPKVQQFLRRMQGVLVARRYVMMDYDIRVEQVERAVALTPGLESPTVSPLHHEGWVAVRSMVPAKDAQRVMDELYELGARAILTTGIHACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ22</accession>
    <name>A0A2G1XQ22_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_03215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53326">
        <property type="protein sequence ID" value="PHQ53326"/>
        <property type="gene ID" value="BLA24_03215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="72" mass="7264" checksum="E7E99C62D4E8EC55" modified="2018-01-31" version="1" fragment="single">TVTGDPGEGLAVEVRNAAPAPGAGTAVPGAGQGLLGLAERAGIAGGRLEHGRDEADFRLRAWLPWPARRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ37</accession>
    <name>A0A2G1XQ37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YncE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02950</name>
        <name evidence="3" type="ORF">CYQ11_05250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53342">
        <property type="protein sequence ID" value="PHQ53342"/>
        <property type="gene ID" value="BLA24_02950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16360">
        <property type="protein sequence ID" value="PPT16360"/>
        <property type="gene ID" value="CYQ11_05250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="41163" checksum="1492B49470DC7593" modified="2018-01-31" version="1">MFTAVGALLVAGCGGPSKDEAADQQPHGAQGAARGVPQGLPGMPPLLDPNDLYAADRPNALSPVVKDFPSRVYVPNTESDSVSVIDPKTYKVIETIPVGEQPQHVVPSWDLKTLWVNNDRGHTLTPIDPATGKAGKPVDVHDPYNLYFTPDGKYAVVMASMDRELVFRDAHTMKRMKTEHVDCLGVNHADFSPDGRYFIVSCEFSGELLKVDTARMKVIAKQKLPFDGAMPQDVKISSDGKTWYVADMMADGLWVLDGDKFTEPSLMPTGKGAHGLYVSRDSKSMYISNRGEGSISVLDLPSRKLVKKWELPEGGSPDMGGVSADGKVLWLSGRYNSEVYAIDTEDGHQIAKIPVGAGPHGLAVYPQPGRYSLGHTGIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQB7</accession>
    <name>A0A2G1XQB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00420</name>
        <name evidence="4" type="ORF">CYQ11_07430</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53434">
        <property type="protein sequence ID" value="PHQ53434"/>
        <property type="gene ID" value="BLA24_00420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12738">
        <property type="protein sequence ID" value="PPT12738"/>
        <property type="gene ID" value="CYQ11_07430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="42426" checksum="A17D58F347A2808A" modified="2018-01-31" version="1">MSPNVISTPVRAMLVLGTRPEAIKLAPLARAMAASPLFDPLVVTTGQHREMLQQMLALLKVPARVELDVMRDRQELSKLTARLIDGLGDVVREQRPDLVVVQGDTTSALTGALAAFYEHVPVAHVEAGLRTGVLDNPFPEELNRRLIGRVARWHFAPTPRAAGHLTAEGVPAAEVFVTGNTVIDNLLWVLEEGTGANLFESDLRRVLVTLHRRENQGDKMRAMGKALRQLADRGDVEIVLPLHKSPAVREALLPELSGHARIRVVEPLDYVDFSATLAGCDLVMTDSGGIQEEAPSLGKPALVLRTTTERPEAVEAGAAALVGTEPHAVLDAAVRLLDDAAAYERMATAGNPFGDGRATERIVAQLAEDFGADAGVLPAPTTLIAPQPDGPGSYSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQH4</accession>
    <name>A0A2G1XQH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_00570</name>
        <name evidence="5" type="ORF">CYQ11_07580</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53460">
        <property type="protein sequence ID" value="PHQ53460"/>
        <property type="gene ID" value="BLA24_00570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12765">
        <property type="protein sequence ID" value="PPT12765"/>
        <property type="gene ID" value="CYQ11_07580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="91"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="30744" checksum="5E956AF27DB1D770" modified="2018-01-31" version="1">MSNRNNPQNKAAARERLRAERERQAKKDKLRRQLLVGGGALAVLAAAVGIGVVVSNATNGSKNTKVSSEDWEAAAKKTEFKQPANSTGDKGTTVVMGKQDAKNTLEVFEDMRCPVCSDFEQNAGETVLKDVKDGKYKVQYKIGTFLDRNPMIKGSGSKNALSALGAALNVGPDAFLDYKKALFAAKNHPNEQDDAFSDDEKLIGIAQQVKALKGNSAFEKDVKDGTFDKWALEMSDAFDKVVGQGKDIQGTPGFKLDGKVLADEQGRTPRTGEQFTALVDKALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQN0</accession>
    <name>A0A2G1XQN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">MoxR family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00790</name>
        <name evidence="4" type="ORF">CYQ11_07800</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53501">
        <property type="protein sequence ID" value="PHQ53501"/>
        <property type="gene ID" value="BLA24_00790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12806">
        <property type="protein sequence ID" value="PPT12806"/>
        <property type="gene ID" value="CYQ11_07800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="240"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="332" mass="36535" checksum="EE66700E4B08D55E" modified="2018-01-31" version="1">MTTYDERASLSDLTSTVERVRRSVESVIEGKPEVVRLALTVLLAEGHLLIEDVPGVGKTMLAKALARSVDCSVRRIQFTPDLLPSDITGVSVYDQQRRDFEFKPGAVFAQIVIGDEINRASPKTQSALLESMEERQVTIDGQTYELPSPFMVVATQNPVEMEGTYPLPEAQRDRFMARVSMGYPSPEAELRMLDVHGGTSPLDDLQPVAHAHEIVKLVDAVRTVHVSDTVRRYAVDLVAATRHHPELRLGASPRATLHLLRAAKAAAALTGREFALPDDVQSLAVSVLAHRLLPTSQAQLNRRTAEQVVVDILQRTPLPDPFGQQPPGVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X980</accession>
    <name>A0A2G1X980_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30240</name>
        <name evidence="5" type="ORF">CYQ11_23335</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47794">
        <property type="protein sequence ID" value="PHQ47794"/>
        <property type="gene ID" value="BLA24_30240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15419">
        <property type="protein sequence ID" value="PPT15419"/>
        <property type="gene ID" value="CYQ11_23335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="282"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1587" mass="168788" checksum="76E425F9A90E5266" modified="2018-01-31" version="1">MGGMANDKAAQAAEDPAAALASFSPATRAWFTGAFTAPTTAQAGAWRAIDAGSDVLVVAPTGSGKTLAAFLASLDRLASSPPPAERQKRCRVLYVSPLKALAVDVERNLRSPLTGIRQESVRLGLPEPEIRVGIRSGDTPAAERRALITRPPDILITTPESLFLMLTSAAREALTGVETVILDEVHAVAGTKRGAHLALSLERLDTLLARPARRIGLSATVRPVDEVARYLSPQRKVEIVQPPSGKEFDLSVVVPVEDLGELGGSPVQEGGDGKERPSIWPHVEERIADLVQAHRSTIVFANSRRLAERLCNRLNEIAHERATGEPLPENHAPAQLMGGSGPAKGAPAVLARAHHGSVSKEQRALVEEDLKAGRLPAVVATSSLELGIDMGAVDLVVQVESPPSVASGLQRVGRAGHQVGAVSTGVVFPKYRGDLVQAAVVTERMRQGAIESLRVPANPLDVLAQQIVAMVSMDPWDVDELLAVVRRAAPFAALPESAYTGVLDMLAGRYPSDAFAELRPRLVWDRVAGTVTGRPGAQRLAVTSGGTIPDRGLFGVFLAGADPKKGGGRVGELDEEMVYESRVGDVFTLGTTSWRIEDITRDRVLVTPAPGTPGRLPFWKGDQLGRPLELGRALGSFLREVGGLTPEAARRRLTAAGLDAWAADNVLSYLDEQRQACGHVPDDRTIVVERFRDELGDWRVVVHSPFGAQVHAPWALALAGRLSERYGMDAQVMHADDGIVLRLPDADLMGLDLLDGDLARQGTEYDTEQSPVGATDVVFDKGEVDRVVTDQVGGSALFASRFRECAARALLLPRRNPGKRTPLWQQRQRASQLLQVAGEFGSFPIVLEAVRECLQDVFDVPGLTELMGDIEARRVRLVEVTTPEPSPFARSLLFGYVAQFLYEGDSPLAERRAAALSLDSRLLAELLGQAELRELLDPEVLTELERELQWLTEDRRVKDAEGVADLLRLLGPLTDAELAERGAEPQWARELADARRALSVRVAGRDHWAAIEDAGRLRDALGTALPVGVPEAFTEPVRDPLGDLLARFARTHGPFTSAEAAARFGLGTAVTDGALHRLAAGGRIVQGEFHPSGIGQEWCDAAVLRRLRRRSLAALRHELEPVPPATLAAFLPQWQHVGSHGLRGTDGLVRAVEQLQGAPVPASALEKLVLPGRVTDYSPAMLDELTASGEVVWAGAGALPGKDGWVSLLLADAAPLLLPAPHPLELSPVHQAVLDALSGGYGLFFRQIAERVRAASPVFEDSAGTDAQIVEALWDLAWSGRLTNDTLAPLRSLLGSGRTAGSTAHRARRPVPRGRYGAALTARTGLASASRSTASRGGPPTVAGRWSLLPEREPDPTLRAHALARTLLDRHGVVTRGAVAAEGVEGGFSAAYRVLSVFEESGQARRGYVVEGLGAAQFAMEGAVDRLRAVGTARERSGPAPEAPWDPRPAAPRATRRTVVLAAADPANAYGAALPWPEPPAGAAHKPGRKAGSLVVLLDGALALYVERGGKTVLAWPQQEGAETPGSDDPGLREAAEALASAARAGALGTVTVERINGSAALTSPLGALLEAAGFHATPRGLRLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9N7</accession>
    <name>A0A2G1X9N7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31015</name>
        <name evidence="2" type="ORF">CYQ11_24115</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47933">
        <property type="protein sequence ID" value="PHQ47933"/>
        <property type="gene ID" value="BLA24_31015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15558">
        <property type="protein sequence ID" value="PPT15558"/>
        <property type="gene ID" value="CYQ11_24115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="463" mass="49714" checksum="607F2B946035AB39" modified="2018-01-31" version="1">MIDWHAAGAYVTALTGADAAGLELFHQRVARGPEFRNKEFPLSPLPLLLTEREAAAYARQLESYGRLLDRIVDLYRSKPAVRAWFSLGPTAEQLVLADTGLDGHVVVCRVDGYLTQGTETPVVLENNADAPAGTLFTARVNNTVHDGLDAMGVYDARGVCGSTAVAPPLSPLTYTDEHALLAALRSCDARRGGTGIEHLAVLQPAGGSNRESVLMAESFRTAGLDAYLADPRDLRLSHGRVFFGDKPADACWNKVNTTGWCALVEADEALAGRWLRAVSDTGFVNVNPFGARYVAENKLALALPQEPDFAALFTDGERALAATLLPWARRLAPGTPGRTSYALLTDELLDQQHAYVLKEPYDIRGDGVTVGRAVSRSTWEKAVARGLAEGHLVQEYVAPVPYPVLRDGGTPAVVPMATSLDGYVMNGEFRGFGAKASLQARVNVFQGGQKLAVHVLGERARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9U7</accession>
    <name>A0A2G1X9U7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_31505</name>
        <name evidence="5" type="ORF">CYQ11_24550</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47985">
        <property type="protein sequence ID" value="PHQ47985"/>
        <property type="gene ID" value="BLA24_31505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15610">
        <property type="protein sequence ID" value="PPT15610"/>
        <property type="gene ID" value="CYQ11_24550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="195"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="363" mass="39824" checksum="3E90641897B156F9" modified="2018-01-31" version="1">MSRKKTTSRKKAAGPARRRTLHALVVLGLLGTSAYLTVELRDRQQEKAPPVQSVGRPEGAAAGKAVPSGERRFERLAGPARTVVRAADGSVLATFTDNARTAVLTGPSRTFTEPNFTEAKVTSDSWVRLLPQQWKEGAEKSAWFKDWFERYLGSQEPDVLAFSMEYLDGAPQKKDVHGLVYAGDAQFGPVNPNGSQAGDLRLEQSDFYDYLGIPYTFRDGTVERPEPQRLRAIDCSGFVRTVFGYRARYPLLGKDVKGDGLPRTADGMARLSPGVPVLELTGKRPENIDKLQPGDLVFFEIDKRTGERLDHVGIYLGLDTDGKPRFVSSREEANGPTFGDKGGTARLDGNGFYAAGLRSAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA11</accession>
    <name>A0A2G1XA11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-3-oxopropionate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32030</name>
        <name evidence="5" type="ORF">CYQ11_25085</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48074">
        <property type="protein sequence ID" value="PHQ48074"/>
        <property type="gene ID" value="BLA24_32030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15700">
        <property type="protein sequence ID" value="PPT15700"/>
        <property type="gene ID" value="CYQ11_25085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006398">
        <property type="entry name" value="Tartro_sem_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01505">
        <property type="entry name" value="tartro_sem_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="171"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="30052" checksum="B404AECA88778695" modified="2018-01-31" version="1">MLADTALPSVAWIGLGIMGAPMAENLLKAGYSVTGYTLEEHKLDRLAAAGGTPAGSVADAVRDADVVVTMLPADAQVAAVAHGDEGVLARARPGALFIDMSSVTPRISRALAEAGAARGLRVLDAPVSGGEAGAVEGVLSVMVGGHPDDFAAAEPLLRVLGTTVVLTGPHGAGQTVKAANQLIVAVTLQACAEAVVFLEKSGVDLAAALDVLGGGLAGSAVLTRKKHAFLARDFTPGFRVDLHHKDMGIVTDAARAVGAAVPVGALVAQLVAALRAQGDGGLDHSALLRGVERLSGGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA61</accession>
    <name>A0A2G1XA61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32185</name>
        <name evidence="7" type="ORF">CYQ11_25240</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48101">
        <property type="protein sequence ID" value="PHQ48101"/>
        <property type="gene ID" value="BLA24_32185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15726">
        <property type="protein sequence ID" value="PPT15726"/>
        <property type="gene ID" value="CYQ11_25240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="30224" checksum="57B54E051E9CAB7E" modified="2018-01-31" version="1">MGPQAGGGEQVSALVKLTDVSKYYGNIRALEGVSLEVHAGDITCVLGDNGAGKSTLIKIIAGLHQHDAGVFEIEGEETKLASPREALDRGIATVYQDLAVVPLMPVWRNFFLGSEPTKGKGPFKRLDVQQMRETTRAELLRMGIDLRDVDQPIGTLSGGERQCVAIARAVYFGAKVLVLDEPTAALGVKQSGVVLKYVAAARDAGLGVVLITHNPHHAYLVGDRFVLLKRGAMAGSHAKSEIALDELTRQMAGGSELDQLSHELERAPGPDVIGGKKIEATEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD2</accession>
    <name>A0A2G1XAD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32655</name>
        <name evidence="3" type="ORF">CYQ11_25705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48175">
        <property type="protein sequence ID" value="PHQ48175"/>
        <property type="gene ID" value="BLA24_32655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15801">
        <property type="protein sequence ID" value="PPT15801"/>
        <property type="gene ID" value="CYQ11_25705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="474" mass="49235" checksum="5CD49B052D5BC356" modified="2018-01-31" version="1">MIKRSTDALEHVWAALGGDPALTAAVVTDGPGGALQARLPVREMARSTVAACALAAAELAAARRGGGTLPAVRVCDGAVATAFVSERHVRVDGRAATSFAPLSRFWRTADGWLRTHANYPHHRARLLAALGVPDSGADEALVPSVAAALARREAARTEEEVHAAGGLAVAVRTPHEWAVHPHGAAVLQRPLLSLERFADGPVRTLGGLPGGASGALPAGGLRVLDLTRVLAGPVATRTLALLGADVLRVDTPALPESQDLHDDTGLGKRSTVLDLARRADRAAFEELLAGADVVVTGYRPGALDRHGLSPQALAERRPGLVVGQVSAWGTYGPWGDRRGFDSLVQAACGIAATEAGDDARPGALPAQALDHGTGYLLAAAVLRALTRQRTEGGTHLARLALAQTAAWLARDVARDAGEPAAGDVHDPGPWLTERPGPLGRVRHALPPVTFDGGPRDWARPAGRWGADEPAWRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD9</accession>
    <name>A0A2G1XAD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32815</name>
        <name evidence="4" type="ORF">CYQ11_25865</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48204">
        <property type="protein sequence ID" value="PHQ48204"/>
        <property type="gene ID" value="BLA24_32815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15830">
        <property type="protein sequence ID" value="PPT15830"/>
        <property type="gene ID" value="CYQ11_25865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="45"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="513" mass="55051" checksum="0F374DB3D15CD9B8" modified="2018-01-31" version="1">MAPTLILRPGTEWATAWQRCQALAPEAFRDDRVLNLWNGLWQADGRPLPATTPVDGTPIAGPPRLDAATAHHAVRASLDQHRAWRDVPLAERKAMVGATLDALAEHRDLLALLLVWEIGKPWRLARADVDRAIEGVRWYVAEIDRMTAGRVPLPGPVSNIASWNYPMSVLVHAMLVQALAGNAVIAKTPTDGGLACLTLACALAAREGLPVTLVSGGGADLSEALVRAPEVGCVSFVGGRDTGARVATAVADLGKRHILEQEGLNTWGVWNFTDWDALAPQIRKTFDYAKQRCTAYPRFVVQRSAFADFLAHYLPAVRSVTFGHPLAVATADEDLPALDFGPLINAAKAKELNDQVAEAVDRGAIPLHRGELSAGRFLPGQDTSAYVPPVTLLSPPSTSPLHHAEPFGPVDTIVLVDTEAELLSAMNASNGALVATLSCDDRAAYERLAPQIRAFKVGHGKPRSRGDREELFGGFGASWRGAFVGGELLVRAVTQGPADERAPGNFPDYHLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF1</accession>
    <name>A0A2G1XAF1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32840</name>
        <name evidence="4" type="ORF">CYQ11_25890</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48208">
        <property type="protein sequence ID" value="PHQ48208"/>
        <property type="gene ID" value="BLA24_32840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15834">
        <property type="protein sequence ID" value="PPT15834"/>
        <property type="gene ID" value="CYQ11_25890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="45004" checksum="E01F94E175DC2DD1" modified="2018-01-31" version="1">MTGPLPAPFRTADVHLPDPYPLYRRYREADPVHWAGDGWYLFRHDDVAHVLTSRRYGRGALPARLPQECPHLRRTTANWMVFMDPPEHTRVRALVAKSFTPRIVRELRPRVRRLATDLVAELGAKATEDATADLVGGFAAPLPILVISELLGVPREDRPWFRAQAVDLQQATSSRVARRADAFAVADAAARELDAYFRAELARRRARKEGFGPDLIGAMLRAEEELPLGEDALVGTCIHLLTAGHETTTNLLAKGLLALFAHPDQLAVLRERPELMPGAVEELVRYDSPVQMISRWAREDDRIDGRAIPRGAKVTLVLGAANRDPGHFPDPDRLDVHRDARRHSGFGMGIHYCVGAPLARVEAEIGLSELLRGLPGLAPADGEAVRYAEDLVFHGPERMMVRIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAK6</accession>
    <name>A0A2G1XAK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33245</name>
        <name evidence="3" type="ORF">CYQ11_26295</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48274">
        <property type="protein sequence ID" value="PHQ48274"/>
        <property type="gene ID" value="BLA24_33245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15904">
        <property type="protein sequence ID" value="PPT15904"/>
        <property type="gene ID" value="CYQ11_26295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="719" mass="76879" checksum="10C655E60A9ABC9B" modified="2018-01-31" version="1">MADPPPPERSALPEALSDASGVPVPGLDDLSFQPLVDAAKRALPQRAPEWTDHNVSDPGVTLIEACAERTDQLLYRVNRMTDRQRSALLRLMGITPLPASPARITVAFARTDARTGLREIPAGTEVRTEGEQPVVLATTAPLVLAENQSTGVVAALEQLVPVAEVLGTSDGRPGGRFATRHRPWRPGTPVAEPPFGPGLTVQVGDSVWPAVRTFAEAGRGDRVHWWDDASCEVVLGPAVPAEGVPEQHGDVPPEGTRISAEYHVYRGRKGSLPIGTPLTVVSQAGLSATADGVLAPAEDAEDWRQALERAGLGLTPLRRAVTAADHEQIIGEHVAGLARVRVTTLTRPTDSRVPIALTQPPRPSEILACAVAAREPVRAVHYFADGESITPLPLPLGGPGESNDDEAVPGPVADAKCLDAVIRTGEGEPRLWFYGTQCLWDGEGASPQDIGSAFPDLPEDFSSQLDAVTVLADPASDDAYELFFFKGETFYHRAYTSTDRAFVPQAESRGVRSLISEAFPGLSPQCQVSPDAVVVIGGVFFFMKGTRTEPALWRREDDPLHVLLVPLFEGDPAQAPPGDAFDVPPDVLDSVVGVVEASRLLGERLRVGTPRYHRFGIAATVRPWSSAAADQERTRRATERALRRFFHPTAGGPDGRGWPWGRRVHAGDVFTVLEAVPEVRGTTEVSLFVGDGAVPSVEVSDGGLVLVDDMVINVDITEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAT8</accession>
    <name>A0A2G1XAT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31715</name>
        <name evidence="3" type="ORF">CYQ11_24770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48348">
        <property type="protein sequence ID" value="PHQ48348"/>
        <property type="gene ID" value="BLA24_31715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16774">
        <property type="protein sequence ID" value="PPT16774"/>
        <property type="gene ID" value="CYQ11_24770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="40"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="290" mass="31186" checksum="A4F5699FAFCF7EC6" modified="2018-01-31" version="1">MDAAFTEQRARALLALTDAAGSAADAELLALGENAVFAVGGLVAKVGRDASLVPRARRELRVGAWLEDCGVPAVRPAASEVLIADGHPVTLWHRLPQAVRPASPADLAKLLRRLHALPAPGFGLPRRDLLGGVERWLRLAGDAVDPADADYLRERRDGFAAATAALTPHLEPGPIHGDALPRNVHVGPDGPVLVDLETFAVDLREHDLVVTALSRDRYGLDPEAYAAFVRAYGWDVREWEGCAVLRGARETASCAWVAQHAPGNPAALAEFRRRVASLRDGDPAVRWYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB09</accession>
    <name>A0A2G1XB09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28950</name>
        <name evidence="4" type="ORF">CYQ11_06525</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48413">
        <property type="protein sequence ID" value="PHQ48413"/>
        <property type="gene ID" value="BLA24_28950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12592">
        <property type="protein sequence ID" value="PPT12592"/>
        <property type="gene ID" value="CYQ11_06525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="67"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="342" mass="36007" checksum="EEBCB3ED2A5EE681" modified="2018-01-31" version="1">MSTPRTFTVSRRGLLAAGGALGVGALLTACGGGGSKGSSDASDGGKGGPWTFKDDRGQTVKAAGTPRRIVAFTGTAAALHDFGVECVGVFGPTRLENGKPDPQAGDLDVDKVTVLGNTWGEFRVEKYAALKPDLLVSNMFEPDALWYVPEESKKKILGLAPSVGLTSARVSMLEPIKRYAQLAESLGADLGAKKVTDAKARFEQAAETLRKAAKANPVKVLAASGSADLFYASNPAVNADLMYFRELGVDLVVPEKLDKGGYFESLSWENADKYQADLILLDSRTSALQPKDLAAKPTWGKLPAVKAGQVAPWLSEPRFSYAGCAPLLEGLAAAIEKAEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB57</accession>
    <name>A0A2G1XB57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29190</name>
        <name evidence="3" type="ORF">CYQ11_06285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48450">
        <property type="protein sequence ID" value="PHQ48450"/>
        <property type="gene ID" value="BLA24_29190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12554">
        <property type="protein sequence ID" value="PPT12554"/>
        <property type="gene ID" value="CYQ11_06285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="53"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="223" mass="24785" checksum="B1D2CBDA8980A219" modified="2018-01-31" version="1">MPHPPLTPAEYWDLYKPYRGGGAQPAPEPGQFEWTQFPGHGPGPELLGTPRTVLELGPGEGADAVYLARRGAQVTGVDFSAFQTERARRWWANEPGVTFIHADVCDFLVTEATEYDAIYSMWGAVWFTDPEQLLPLVAKRLAPEGVFIFSHAEPGPDAYGPQQMRGKWLEGRERQLTVLRWQYPPQTWADLLKRSGFTDIDARIVPPPGDETLGTLLVRAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBF4</accession>
    <name>A0A2G1XBF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29900</name>
        <name evidence="2" type="ORF">CYQ11_05570</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48563">
        <property type="protein sequence ID" value="PHQ48563"/>
        <property type="gene ID" value="BLA24_29900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12435">
        <property type="protein sequence ID" value="PPT12435"/>
        <property type="gene ID" value="CYQ11_05570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="445" mass="47932" checksum="8E7455BC47EE436C" modified="2018-01-31" version="1">MEPNTLLDAILDEAGISHAGLAAHINAAGRARGLALRYEHTAVARWLKGQRPRGQVPDLICEVLGERLHRALTLDDIGLGTPGTPRASGTPLSGFVERATALWRSDEQQREHVVRAPAVTGTPAVIPVWEWENPPEDADVSRRGLTRVSMDDIAMLRAARTHYEQMYRKAGGIATRTRVVGFLNAEAAPLLRGSYSDAMGRQLHRATGGLVAVAGICAYDSDAHGLAQRYFHQALRLAKASGDRGLGAYVIALLVNQSLFTGEYRQAVAFAESALRAGHNDLTPALAADLYAMQAKAYARLGDGAGALACIRRAESAAERIHRGQEPAETGYVQPGLVNVQVAEALLSLGDLGPAREHADRAVDTPAHDRGRVHRLAMLTHIELRQGDADKAVATAREMTEQARGMESQRLRDRLRAVREHLIESGCAATAEAAEMIDGALRVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBF5</accession>
    <name>A0A2G1XBF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29875</name>
        <name evidence="3" type="ORF">CYQ11_05595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48558">
        <property type="protein sequence ID" value="PHQ48558"/>
        <property type="gene ID" value="BLA24_29875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12440">
        <property type="protein sequence ID" value="PPT12440"/>
        <property type="gene ID" value="CYQ11_05595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="29636" checksum="4DE32687393AE9F8" modified="2018-01-31" version="1">MGTPELISPRSPRVIAARRLAKRSFRVKERRFIAEGPQAVREAIDHRSAGEPTLVELFATVEAAERHAEIVGAARAAGVRFHLATDDVIADLSQTVTPQGLVGVCRFLDSPFEEILAARPKLVAVLAHVRDPGNAGTVLRCADAAGADAVVLTDASVDLYNPKSVRASVGSLFHLPVAVGVPVEQAVRGLGDAGVRILAADGAGERDLDGELDEGTMGGPTAWVFGNEAWGLPEETRALADAVVRVPIHGKAESLNLATAAAVCLYASARAQRASGGCRSVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH0</accession>
    <name>A0A2G1XBH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_29365</name>
        <name evidence="6" type="ORF">CYQ11_06110</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48594">
        <property type="protein sequence ID" value="PHQ48594"/>
        <property type="gene ID" value="BLA24_29365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16371">
        <property type="protein sequence ID" value="PPT16371"/>
        <property type="gene ID" value="CYQ11_06110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="472" mass="48801" checksum="43F67709077550A3" modified="2018-01-31" version="1">MSNHDGMYIGGSWRPAAGRGVTEVVNPADEQVIATVPAGDGEDVDAAVRAARAALPAWSATAPARRGEHLVALRDALDARREEIAATVTAELGSPIGFARRVHVGLPVAVTASYAELAATYAFEERVGNSTVLHEPVGVVGAITPWNYPLHQIVAKVAPALAAGCTVVLKPAEDTPLTARLFAACVAEAGLPAGVFNMVTGLGPVAGRALAEHPGVDLVSFTGSTAVGRQVGAVAAGAVKRVALELGGKSANVILPGADLPKAVTVNVADVMRNAGQSCNALTRMLVHADRYEEAVALAAEAAASYVPGDPADPETRLGPVVSRAQRERVVGYIRKGVAEGARLVTGGPEAPEGREKGHWVRPTVFADVTGDMTIAQEEIFGPVLSVLRYETEEEALALANGTPYGLGGAVWAADDATAAAFARRMDTGQVDVNGGRFNLLAPFGGHKQSGVGREMGVHGLTEYLQTKSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBL4</accession>
    <name>A0A2G1XBL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29695</name>
        <name evidence="5" type="ORF">CYQ11_05780</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48600">
        <property type="protein sequence ID" value="PHQ48600"/>
        <property type="gene ID" value="BLA24_29695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16366">
        <property type="protein sequence ID" value="PPT16366"/>
        <property type="gene ID" value="CYQ11_05780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758456" evidence="3">
        <location>
            <begin position="25"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="412" mass="41811" checksum="B528F9296338B830" modified="2018-01-31" version="1">MLKTRHAARLLTGTLVGRLPNATAALAIVLFVRAEGGSYTLAGALSAVYGVANAVGQPLLGRAVDLYGQPRVILPSAVMTALGMAVFTVVGLDPLPLTYTAMIVAGFFAPPLEGGLRALWPSVLKNEDDLHAAYSLDAIAQELIYVVGPLIVTRIVAIWSEAAALNALHLMGVAGALAVVTSPPSRSWRSAPREAHWLGALRSRGLLVLLGTFFFIGSALGSIAVAAVAYGDAHGGGNISGWLLSALGVGALIGGSVHGARQWPGSPEQRLRVLVGGLALLYVPLVLVPGVVAMTVLAGVAGLFLAPCLATAFVVVDRHAPRGTVTEAFSWLVTSFGVGAAIGTAFVGPAVQSGGARSGFLVAVGGGAAALAVIVAARRALRAPEVPSTVVARSENDRSGAVEPGFSAGHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC24</accession>
    <name>A0A2G1XC24_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_04395</name>
        <name evidence="5" type="ORF">BLA24_04410</name>
        <name evidence="3" type="ORF">BLA24_27355</name>
        <name evidence="6" type="ORF">CYQ11_18295</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000068">
        <property type="protein sequence ID" value="PHQ52996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000068">
        <property type="protein sequence ID" value="PHQ52997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48793">
        <property type="protein sequence ID" value="PHQ48793"/>
        <property type="gene ID" value="BLA24_27355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52996">
        <property type="protein sequence ID" value="PHQ52996"/>
        <property type="gene ID" value="BLA24_04395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52997">
        <property type="protein sequence ID" value="PHQ52997"/>
        <property type="gene ID" value="BLA24_04410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14558">
        <property type="protein sequence ID" value="PPT14558"/>
        <property type="gene ID" value="CYQ11_18295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="104" mass="11158" checksum="3EF0BAE0867823AE" modified="2018-01-31" version="1">MSATESPAATATRRPAATGAHTDEAVDVITDARGRIDDLDGRIIGLVQERMAVSAVIQRERIASGGRRVSLSREMEVLGHYSEQLGRPGTALAMTLLELCRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC49</accession>
    <name>A0A2G1XC49_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_27320</name>
        <name evidence="8" type="ORF">CYQ11_18335</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48788">
        <property type="protein sequence ID" value="PHQ48788"/>
        <property type="gene ID" value="BLA24_27320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14563">
        <property type="protein sequence ID" value="PPT14563"/>
        <property type="gene ID" value="CYQ11_18335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="527" mass="55836" checksum="29F7E3DC4B7A13D4" modified="2018-01-31" version="1">MGTVWRAEDELLARQVALKRLHVPLGLEEDELATLYERTRREARSAARINHANVVVVHDVVEDGGLPCIVMEYVPSTTLGDLLKRGTVSPDEAARIGRGMVAALRAAHAAGVLHRDVKPGNVLLGHDGRVVLTDFGIAHSTGTSTLTKTGEMVGSIDYIAPERVKGAKPGPAADLWALGATLYQALEGRPPFRKDTAVETAYSIAMDPLVPPRNAGPLTKLVETLLAKDPALRPPAELVEQILREPAAEPATASMRPPAASRGGVTAAGPPPGPPAGAGAGTATGTTAAVPTAATTAAPTTTSPTATATAATPRTPAKRRRAGWIATAATVVALVLAAGAYVLSKDGGADEEADAAPPSATPAPSRSSDAPAPPPVPKGYHLVEEKKVGVSFPVPDGWRREKIEENDSIVYVDPSGLVGLRVSVLDLASTDPLQHWKDDEAKSQAEGKLPGYRQLRMQSTTYRGRPAAIWEFTFKGRARDFRAADLGFGRPGEKEYAIYLSAPKAEWDRHKKVFDDVRDGFRMPEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC58</accession>
    <name>A0A2G1XC58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_27390</name>
        <name evidence="9" type="ORF">CYQ11_18255</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48798">
        <property type="protein sequence ID" value="PHQ48798"/>
        <property type="gene ID" value="BLA24_27390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14552">
        <property type="protein sequence ID" value="PPT14552"/>
        <property type="gene ID" value="CYQ11_18255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="30"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="488" mass="48870" checksum="137171462963C535" modified="2018-01-31" version="1">MPTGTSPARTAPGRVPVPPPAPGSRSAAAVLAIACAAQFMVILDVSIVNVALPSMRAELHLSGAGQQWIVNAYTLGFAGLLLLGGRMADLIGTRRAFLGGLTVFTLASLAGGFATNGAWLIGARAAQGVGGAVLAPATLTLIMTTFTEPAARTRAMGAWSAVMAAGGAAGAVVGGVLTQYAGWRWVLFVNVPLGAVLLAAALVCVRAGAVREGGLRRLDLPGAVTVTAGLTSLVYGIIASETHGWGSLAVWGPVAAAVVLLAAFVAVEARAAHPLVPLAIFRRRTLATANMVVVAISAAMFSMWFLLSLYLQQALGYSAVRAGLCFLPGSLAIIVASRIATRLLGRTGARPLLLTGLALSTAGFAWLSLVGGHGSYATDVVAPFVLAAFGTGLATMPTTVTATSGTAPGEAGLASGLVNTSRQVGGALGLALLGTIASHTTAARLAAHPGDVRDALAAGYGRGLLVAAVCTAVAALIGLALPRRRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCA5</accession>
    <name>A0A2G1XCA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27545</name>
        <name evidence="3" type="ORF">CYQ11_18100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48825">
        <property type="protein sequence ID" value="PHQ48825"/>
        <property type="gene ID" value="BLA24_27545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14529">
        <property type="protein sequence ID" value="PPT14529"/>
        <property type="gene ID" value="CYQ11_18100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="954" mass="100863" checksum="D12CAE1960CB47AE" modified="2018-01-31" version="1">MADHERRDGDLSRALARALRPVVRGEVAFDAGSRALVTMDASNYRRVPLGVVAPRDADDVAAALAVCRAHGVPVVPRGGGTSVAGQATGEGVVLDFTRHMNTLVRVDPEAHTAVVQPGLVLDGLRAAAAAHGLTFGPDPSTHGRCTLGGMIGNNACGSHSVAWGTTADNVCALEVLTYGGEHARLSRGTEGLPPRLADGLRALTAENLALLRTRFPRLPRRISGYALDALLPERGTDVARAFTGGEGTLGVVTEATVRLVEAPPARALVVLGYPDEGAAADAAPSLLPHGPLTVEGMATDLVGRVAGLPEGGAWLFAEVGGATPAEAADRAAALVRAARDGGPTGHLVLTEPGAQRALWRVREDAAGFATRLPDGGEAWPGWEDCAVPPERLGAYLRDFRALLGRYGLRGAPYGHFGDGCVHVRLDVDLLTSEGVRRYRRFSGDMADLVVAHGGSLSGEHGDGQARAELLPRMYGPQAVALFERFKDLWDPLGGLNPGMVVRPYPLDANLRFAVLPGKPVDVEFGYRDDGGDFGAAVRRCVGVAKCRQTTVDTGVMCPSYRVTGEERHSTRGRARLLHEMLAGEVVTGGWRSQEVREALDLCLACKGCRSDCPVGVDMATYKAEFLHHHYAGRVRPAAHYALGWLPLWLRAAAAVRAAPVLNAAARTPLAALAKRLGGLAADRTIPELPGEPFTRWWRARGPGRPAGDGVPVVLWPDTLTTHLSPETGRAAVAVLEDAGLRVIVPPRPVCCGLTWVSTGQLTRARAVLRRTLDVMAPALAAGLPVVGLEPSCTAALRTDLPELLPDDPRAARLAAAVRTFARTVEEYAPHWTPPRVGRPVAGQTHCHQHAVLGDAAERRLREKAGLTGPLSGGCCGLAGDFGFTRGHEEVSRACAEEQLLPSLRQAPEGAEILADGFSCRTQIGQLAGVRARHLAEVLAQALRERNDPAPPGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCC3</accession>
    <name>A0A2G1XCC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_27705</name>
        <name evidence="9" type="ORF">CYQ11_17935</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48851">
        <property type="protein sequence ID" value="PHQ48851"/>
        <property type="gene ID" value="BLA24_27705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14502">
        <property type="protein sequence ID" value="PPT14502"/>
        <property type="gene ID" value="CYQ11_17935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="343" mass="33842" checksum="D6CF77017FE32084" modified="2018-01-31" version="1">MPAAVPTSSPGPSTVRRRVGWTAAAVVALLAAVLLSLAVGARPVAPGHVLHALFHDGTDADTAVVRTMRVPRTLVGLMVGAALAMAGTVLQGITRNPIADPGVLGISQGAAVGVVLAIAVAGVHTLTGYVWFAFAGAAAAGVAVYAVATRGRGGASPVKLALAGAAVHALLVSVVNGVLTTRASALDEFRFWQVGSLAGRDGAIAAQIWPFLLAGTVLVLAVARGLDALALGEDVARGLGSNVGAVRIVGGLGAVVLTGAGVAAAGPIAFLGLAVPHLARALVGTSHRWVLPTAALLGPVILLGADVAGRVVFAEGEVPAGVMTALIGVPFLVAMVRRKAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCE3</accession>
    <name>A0A2G1XCE3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_27815</name>
        <name evidence="9" type="ORF">CYQ11_17825</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48871">
        <property type="protein sequence ID" value="PHQ48871"/>
        <property type="gene ID" value="BLA24_27815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14482">
        <property type="protein sequence ID" value="PPT14482"/>
        <property type="gene ID" value="CYQ11_17825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="212"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="233"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="713" mass="76398" checksum="021357559070249E" modified="2018-01-31" version="1">MPGGPAVPAFPPADPSVTDTPTPVTDTADATDTADAAGPLARERAHLASSRAALRAMRADVEALDIKDVAANWVNAQVLRRQIDERITALADLAHTPLFFGRLDYLHAPGAERAEGAGGEQFYIGRRHVHDAAGDPMVIDWRAPVSQPFYRASKKEPMDVRLRRRFGYTGGELTAYEDEDLTDTTSDDRASRLLQSEIERPRVGPMRDIVATIQPEQDEIVRAGIGGTVCVQGAPGTGKTAVGLHRVAYLLYAHRERLARTGTLVIGPNRSFLRYIEQVLPALGELNVAQATVDDLVAHVEVRGTDDPVAARLKGDARMAEVLRRAVRSGVTMPVEPVIVVRGSRRWRVPAYEIEEMVRELLARDMRYGAAREALPQRIAHAVLVRMEEAGEAPDDRVQDAVARNAAVKAAVKAIWPAVDPAKLVLRLLSDAEFLAEHAAGVLDEDEQRAVLWAKPARGVKSAKWSSADAVLVDEASDLVARTPSLGHVVLDEAQDLSPMQYRAVGRRCTTGSATVLGDLAQGTTPWATTSWAEALAHLGKPDAAVEELTQGFRVPREVIAYASRLLPAIAPGLAEATSVRESAGDFSVREVAPEALDAAVLGACREALGREGSVGLIAADDRIPVLTGVLTAAGLPFLAPGEETSADSRLTLVPASLAKGLEYDYVVLDEPAAVVAAEPDTRTGLRRLYVALTRAVSGLAVVHARPLPEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCH3</accession>
    <name>A0A2G1XCH3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27995</name>
        <name evidence="3" type="ORF">CYQ11_17645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48901">
        <property type="protein sequence ID" value="PHQ48901"/>
        <property type="gene ID" value="BLA24_27995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14450">
        <property type="protein sequence ID" value="PPT14450"/>
        <property type="gene ID" value="CYQ11_17645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="39"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="20939" checksum="512849D3E3B474D7" modified="2018-01-31" version="1">MRPGGAAASVRRVFQTTSPTGTAIAHPEGVTADEFRAALARLAAGVVLVTAHDPEDGPRGEDVGMTATAFLSVSLEPPLVMVSVRNGSRMDDLLERQPLWGVSVLAESQRHVAGRFAMKGRLSDRLLFEDLAYERGTSTGAPLIRGALALLECRTEQRVAAGDHTLVIGRVLRAEAPSTEGGPLTYFRGRYRFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCP2</accession>
    <name>A0A2G1XCP2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Type VII secretion-associated serine protease mycosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mycP</name>
        <name evidence="15" type="ORF">BLA24_22975</name>
        <name evidence="16" type="ORF">CYQ11_23100</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48971">
        <property type="protein sequence ID" value="PHQ48971"/>
        <property type="gene ID" value="BLA24_22975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15384">
        <property type="protein sequence ID" value="PPT15384"/>
        <property type="gene ID" value="CYQ11_23100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304843" evidence="13">
        <location>
            <begin position="41"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="14">
        <location>
            <begin position="83"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ48971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT15384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="417" mass="43356" checksum="8B9A8C357ACF99E6" modified="2018-01-31" version="1">MRTPPVTTLRRAPLRAALVLLTAAALTTAAAPAPLGPATGLTLAGSGQCTYPAKPIKGTPWSLQRVILDQLWQDTKGRNAKGRPVRVAVIDTGVDVSNPQLKDAVDTKSGADLLSDAKDQNKGQTNDVVGHGTKVAGIIAARPQADTGFVGIAPESVVISIRQNDEKGTGTSKTLAQGIAKAVADGADVINISQDTAKPLRPDSDLELAVKDALAKDVVVVASAGNDGLDGTVKETYPAAYKGVLAVAASDRNNERAVFSQPGDFVGVAAPGVEMVSTVPKGGQCVDNGTSFSAPYVAGVAALLRAKHPDWKQHQIVAQIEQTAERPGNAHDRYIGWGVVDPVRALTEDDHPIDAVTVDKNPARDVRPPTLPALALGETPQERKERLATYALGGGGVLVALIAGVAVVIRDRKRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCR9</accession>
    <name>A0A2G1XCR9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="12" type="ORF">BLA24_23340</name>
        <name evidence="13" type="ORF">CYQ11_22735</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49033">
        <property type="protein sequence ID" value="PHQ49033"/>
        <property type="gene ID" value="BLA24_23340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15321">
        <property type="protein sequence ID" value="PPT15321"/>
        <property type="gene ID" value="CYQ11_22735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="99"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="100"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="515" mass="55336" checksum="73E7DCC649CC480E" modified="2018-01-31" version="1">MFDTLSDRLAATFKSLRGKGRLSEADIDATAREIRIALLEADVALPVVRAFIKQVKERALGSEVSQALNPAQQVIKIVNEELVGILGGETRRLRFAKTAPTVIMLAGLQGAGKTTLAGKLGRWLKAQGHSPLLVACDLQRPNAVNQLSVVAERAGVGVYAPQPGNGVGDPVQVAKDSIEFARAKQYDIVVVDTAGRLGIDAEMMQQAADIRDAVQPQEILFVVDAMIGQDAVNTAEAFRDGVGFDGVVLSKLDGDARGGAALSVAHVTGKQIMFASNGEKLDDFDAFHPDRMASRILGMGDMLSLIEKAEQTFSQDEAEKMAAKLAKGPKEFTLDDFLSQMEQVRKMGSISKLLGMLPGMGQIRDQINNLDERDVDRTAAIIKSMTPAERQDPTIINGSRRARIAKGSGVDVSAVKNLVERFFDARKMMSRMAQGGGMPGMPGLPGMGGGAGRKKKQQKQAKGKRQSGNPMKRKAEEQAAAERREQAQAGNPLGLPAGQDAEKFELPDEFKKFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD48</accession>
    <name>A0A2G1XD48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_24065</name>
        <name evidence="7" type="ORF">CYQ11_22005</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49148">
        <property type="protein sequence ID" value="PHQ49148"/>
        <property type="gene ID" value="BLA24_24065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15201">
        <property type="protein sequence ID" value="PPT15201"/>
        <property type="gene ID" value="CYQ11_22005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="290" mass="31847" checksum="AA1FC95C2E26CA39" modified="2018-01-31" version="1">MTRARAHRTALRWLPLAPATTLLLLFLAGPIAYCVWLAFTDTQLTGQASASFVGLANFRRAFADDGFRNAVLLTLVFTVLSSLVGQNTLGFALAALMRRASKPVRTLTGAVVIAAWVLPEIVAAFLLYTFFNRRGTLNAVLEWLHLPQQNWLFTLPILAVSFANVWRGTAFSMLVYSAALAEIPQDVTEAAEVDGASGLRRLWHITLPMIRRSIGTNLMLNTLQTLSVFGLIWAMTRGGPGDRSQTLPVFMYDQAFLKSLIGYGTAIALLLLLVGAVFSAVYVRLLREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD74</accession>
    <name>A0A2G1XD74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23815</name>
        <name evidence="4" type="ORF">CYQ11_22255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49109">
        <property type="protein sequence ID" value="PHQ49109"/>
        <property type="gene ID" value="BLA24_23815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15243">
        <property type="protein sequence ID" value="PPT15243"/>
        <property type="gene ID" value="CYQ11_22255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758322" evidence="2">
        <location>
            <begin position="31"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="14858" checksum="E4343BA6178C19E7" modified="2018-01-31" version="1">MKLRHIRTAAISGIALVALAGTSGCGGQSAEQDSGSAATPAADTATSADAAREALREVKVSDCAYAGKQGVTAQLSATNSSATATYSYKVTVKFTAPDGTALATQTPSMPFVRPGRTDTLDIATPYAPKAGASTGGVKCEVAGVERTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD80</accession>
    <name>A0A2G1XD80_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24040</name>
        <name evidence="2" type="ORF">CYQ11_22030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49145">
        <property type="protein sequence ID" value="PHQ49145"/>
        <property type="gene ID" value="BLA24_24040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15205">
        <property type="protein sequence ID" value="PPT15205"/>
        <property type="gene ID" value="CYQ11_22030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="82" mass="9380" checksum="4FC77B3A5104BA7A" modified="2018-01-31" version="1">MSVFIKLVENRPPKEYANERRADISYDDTVEENSEITYQYDVLASGALRILRVTRGEEAVIHAVYAPGLWFRVEGLCRGTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD93</accession>
    <name>A0A2G1XD93_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">BLA24_24170</name>
        <name evidence="13" type="ORF">CYQ11_21905</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49165">
        <property type="protein sequence ID" value="PHQ49165"/>
        <property type="gene ID" value="BLA24_24170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15185">
        <property type="protein sequence ID" value="PPT15185"/>
        <property type="gene ID" value="CYQ11_21905"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="341" mass="36433" checksum="2D17F1D2864AA06C" modified="2018-01-31" version="1">MRIGVLTAGGDCPGLNAVIRSVVHRAVVGHGDEVIGFEDGFKGLLDGRHRKLDLDAVSGILARGGTILGSSRLERARLREACESSKELAREYGIDVLIPIGGEGTLTAARMLSDAGLPVVGVPKTIDNDISSTDRTFGFDTAVGVATEAIDRLKTTAESHQRVMVVEVMGRHAGWIALESGMAGGAHGICLPERAFDPADLASMVEERFARGKKFAVICVAEGAHPAEGTMDYKKGAIDQFGHERFAGIGTKLAGELERRLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAAHRGDFGKMTALKGTDIRMVPLAEATTELKRVPENRMDEAESVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDA6</accession>
    <name>A0A2G1XDA6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ORF">BLA24_24410</name>
        <name evidence="15" type="ORF">CYQ11_21660</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49212">
        <property type="protein sequence ID" value="PHQ49212"/>
        <property type="gene ID" value="BLA24_24410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15137">
        <property type="protein sequence ID" value="PPT15137"/>
        <property type="gene ID" value="CYQ11_21660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="153"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="383"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ49212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT15137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="523" mass="56548" checksum="89554C689F036863" modified="2018-01-31" version="1">MAELTIRPEEIRDALENFVQAYKPDAASREEVGTVSVAGDGIAKVEGLPSAMANELLKFEDGTLGLALNLEEREIGAVILGEFSGIEEGQPVQRTGEVLSVAVGEGYLGRVVDPLGNPIDGLGEIATEGRRALELQAPTVMQRKSVHEPMETGYKAVDAMTPVGRGQRQLIIGDRQTGKTALAVDTIINQRDNWRTGDPKKQVRCIYVAIGQKGSTIASVRAALEEAGALEYTTIVAAPASDPAGFKFLAPYTGSAIGQHWMYQGKHVLIVFDDLSKQADAYRAVSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDEMGAGSMTGLPIVETKANDVSAFIPTNVISITDGQCFLESDLFNAGQRPALNVGISVSRVGGSAQHKAMKQVSGRLRVDLAQFRELEAFAAFGSDLDAASKSALERGKRMVELLKQSQYAPYSTEDQVVSIWAGTTGKMDDVPVEDIRRFERELLDYLHREHKGLMTSIVEGGKMSDDTLQAVGDAIASFKQQFETSDGKLLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC7</accession>
    <name>A0A2G1XEC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26555</name>
        <name evidence="4" type="ORF">CYQ11_19080</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49587">
        <property type="protein sequence ID" value="PHQ49587"/>
        <property type="gene ID" value="BLA24_26555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14694">
        <property type="protein sequence ID" value="PPT14694"/>
        <property type="gene ID" value="CYQ11_19080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304600" evidence="2">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="16909" checksum="B40356C34D5CB9E5" modified="2018-01-31" version="1">MIKRIAAAAALAGAALSMSSAATVVADPLAPTPVPPPSSSAGPLKVTAPPKPAPAPSKSAPAKTAPAKSAPAKAAPAQGAQAKAAPAKPTPAKSASPAKPVPVKPAPAKPAPAKAGPKGMYAQGAPAGVQPPKGVPAAPEHELPETSLYPGVVNGLGKLDQLGQLKEVGSATSALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEG0</accession>
    <name>A0A2G1XEG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26730</name>
        <name evidence="3" type="ORF">CYQ11_18905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49618">
        <property type="protein sequence ID" value="PHQ49618"/>
        <property type="gene ID" value="BLA24_26730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14662">
        <property type="protein sequence ID" value="PPT14662"/>
        <property type="gene ID" value="CYQ11_18905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="224"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="395" mass="43317" checksum="45003CCF40F75208" modified="2018-01-31" version="1">MTEPDFLTTVRTFYDAVAVDYADRYRDQLAAKPLERAMLAGFADLVRGGGGGPVADLGCGEGRVTAHLHALGLSVRGIDLSPRMIELARRDRPGLRFDVGSMLALDLPDGALAGALAWYSIIHTPQERLPDLFAELHRVLAPGGHALIAFQVGDEPLHLEGPFGHDVSLDFHRRRPDRIAELLGEAGLDVTARMVREPEDGVEKVEQAFLIARKAPEPHRFDLVQIADGDDVTPELRRQLTDCWTEVTNAGGAAGFPFPPVGHGEVAPAVEKLAGRLDARNSRLVLARVGDALAGWVFLSRDPDRLVAHWGTLHHLQTHPDFRGRGIGSALVRRARDVARDELGLEQLRLAARGGEGLEAFYERLGWRETGRWPSALRFTPDDTRDEVLMTLAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI7</accession>
    <name>A0A2G1XEI7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_26565</name>
        <name evidence="13" type="ORF">CYQ11_19070</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49589">
        <property type="protein sequence ID" value="PHQ49589"/>
        <property type="gene ID" value="BLA24_26565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14692">
        <property type="protein sequence ID" value="PPT14692"/>
        <property type="gene ID" value="CYQ11_19070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="119"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="505"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="584" mass="61652" checksum="72204E61BEBDEAB6" modified="2018-01-31" version="1">MRKVLIANRGEIAVRVARACRDAGIGSVAVYADPDRDALHVRAADEAYALGGDTPATSYLDMTKVLAAAAESGADAVHPGYGFLSENADFAQAVIDAGLTWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTADPVSGAEEVVAFAEEHGLPIAIKAAFGGGGRGLKVARTLEEVPELYDSAVREAVAAFGRGECFVERYLDRPRHVETQCLADKHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLNDEQNAELYRASKAILKEAGYEGAGTCEFLVGQDGTISFLEVNTRLQVEHPVTEEVTGIDLVREMFRIADGEELGYDDPPMRGHSFEFRINGEDPGRNFLPAPGTVTAFTPPSGPGVRLDAGVESGSVIGPAWDSLLAKLIVTGATREQALQRAARALAEFQVEGMATAIPFHRAVVTDPAFTADPFRVHTRWIETEFENTIPPFAGQGAEEDEEAAGRETVVVEVGGKRLEVSLPASLGMTLARTAAAGGAKPKRRAAKKSGSAASGDALASPMQGTIVKVAVEEGQEVNEGDLIVVLEAMKMEQPLNAHRSGTVKGITAEVGASVSSGAVICEIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEM0</accession>
    <name>A0A2G1XEM0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cysC</name>
        <name evidence="3" type="ORF">BLA24_27080</name>
        <name evidence="4" type="ORF">CYQ11_18550</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49676">
        <property type="protein sequence ID" value="PHQ49676"/>
        <property type="gene ID" value="BLA24_27080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14601">
        <property type="protein sequence ID" value="PPT14601"/>
        <property type="gene ID" value="CYQ11_18550"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="181" mass="19169" checksum="A57F009BA005E7E7" modified="2018-01-31" version="1">MSGTTPGATVWLTGLPSAGKTTIARALAGRLRGVGGRVEVLDGDEVREFLSAGLGFSREDRFVNVERIGFVAQLLASHGVLVLVPVIAPYADAREAVRERHRVRGTGFVEVHVATPVEVCAVRDVKGLYARQAAGRLSGLTGVDDPYEVPVAPDLRIAAHEQSVAESAEAVHDLLRGRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFA2</accession>
    <name>A0A2G1XFA2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19350</name>
        <name evidence="3" type="ORF">CYQ11_11450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49809">
        <property type="protein sequence ID" value="PHQ49809"/>
        <property type="gene ID" value="BLA24_19350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13415">
        <property type="protein sequence ID" value="PPT13415"/>
        <property type="gene ID" value="CYQ11_11450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="6623" checksum="B7651A2009CC5C9D" modified="2018-01-31" version="1">MTCDRLVCANCAAPVSEGRCPVCRASRERLQHQEGAFGALTPAALIALLVVLLAVALLARGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFG6</accession>
    <name>A0A2G1XFG6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding protein</fullName>
            <ecNumber evidence="6 7">1.3.5.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">BLA24_20330</name>
        <name evidence="7" type="ORF">CYQ11_10455</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6 7"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49967">
        <property type="protein sequence ID" value="PHQ49967"/>
        <property type="gene ID" value="BLA24_20330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13256">
        <property type="protein sequence ID" value="PPT13256"/>
        <property type="gene ID" value="CYQ11_10455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="47"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="513"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="648" mass="71481" checksum="22668B0E7A9C5C83" modified="2018-01-31" version="1">MSAYTHYTVGEPLADTKAPTGPVAERWDRRRFEAKLVNPANRRKHTVIVVGTGLAGAAAGATLAEQGYRVVQFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSVHRLFYDTVKGGDFRARESNVHRLAQVSVEIIDQCVAQGVPFAREYGGLLDTRSFGGVQVSRTFYARGQTGQQLLLGAYQALSRQIGAGNVEMHARTEMLDLIVVDGRARGIVARDLITGRVDTHLADAVVLASGGYGNVFHLSTNAKNSNATAVWRAHRRGAHFANPCFTQIHPTCIPRSGDHQSKLTLMSESLRNDGRIWVPKAKGDTRPPAGIPEGERDYYLERMYPSFGNLVPRDIASRAAKNVCDEGRGVGPGGQGVYLDFADAIARMGRDAVEARYGNLFEMYERITAENPYEVPMRIYPAIHYTMGGLWVDYDLQTTVPGLFAVGEANFSDHGANRLGASALMQGLADGYFVLPSTINDYLARHPHDEIAPGHRAVTEAVDAVTDRLSRLLAADGDRTPESFHRELGELLWDECGMARTETGLRKALDRIPALREEFWRRVKVPGTGEELNQQLEKANRVVDYLELAELMCLDALHRTESCGGHFREESQTADGEAARDDEAFAYVAAWEFTGEGTAPVLHKEDLRFEYVHPTQRSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG07</accession>
    <name>A0A2G1XG07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21500</name>
        <name evidence="5" type="ORF">CYQ11_09285</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50157">
        <property type="protein sequence ID" value="PHQ50157"/>
        <property type="gene ID" value="BLA24_21500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13059">
        <property type="protein sequence ID" value="PPT13059"/>
        <property type="gene ID" value="CYQ11_09285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="239"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="478" mass="49262" checksum="15742F326705856B" modified="2018-01-31" version="1">MGIVAGLDSSSESTRIVVCDADTGTVLRQGYAPHPPSSPEGDPQAWLISLGEAAAGGLLEGVQAIGVSAQQHGLLTLDAGGVLVRPALLGNDKRVQAAAADLTEALGGRTAWAEAVGAVPQAAQPLAKLRWLARNEPESAARVAAVLQPHDWLVWQLLGRPLRRTTDRGDASGTGFWSAATESWRPDLVELALGRQTSLPDVLGPAEPAGHTPEGLLISAGTGETMAAAFGLGLGLGDAVISLGASGSVFAVHHSALADSSGTITSFADATGMHLPVVHTLNAVRVLRGTAELLGTDLPGLSDLALASSPGSYGMVMLPYLEGERTPHLPHTAGSLTGLRRESMKREHLARAAFEGMLCGLTDALDVLRGRGVDVRRVFLLGAAAELPAVQATAPSLFGTQVVVPQPADYAALGAARQAAWSLGVQQGVLSPQQPPLWPAAATQVFEPTGDELAVGHAVRQQYTTVREQTHPGAFGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG17</accession>
    <name>A0A2G1XG17_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21570</name>
        <name evidence="3" type="ORF">CYQ11_09215</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50167">
        <property type="protein sequence ID" value="PHQ50167"/>
        <property type="gene ID" value="BLA24_21570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13049">
        <property type="protein sequence ID" value="PPT13049"/>
        <property type="gene ID" value="CYQ11_09215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="261" mass="27768" checksum="651D0460711FA6AD" modified="2018-01-31" version="1">MRDLVAGMTYLVKGQRWVGRNRRQWGFGLLPGLITLAGYAAAVVALVLWSDDAVAWATPFADGWGSPWLGLFRGALTAVFFGGCLLLALISFTAVTLLVGQPFYEALSERVDAAEGGEAPASGLPLWRELWISARESLAVLVRVAVWGVLLFALGFVPVLGQTVVPAIGFCVSGFFLAEELTAVALQRRGVPLRERLRMLRSRKLLTLGFGVPLALLFLVPLVAVFVMPGAVAGATLLVRDLTGEAEAPLPRAGAGELTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG86</accession>
    <name>A0A2G1XG86_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03710</name>
        <name evidence="1" type="ORF">BLA24_21450</name>
        <name evidence="3" type="ORF">CYQ11_09335</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000051">
        <property type="protein sequence ID" value="PHQ53091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50149">
        <property type="protein sequence ID" value="PHQ50149"/>
        <property type="gene ID" value="BLA24_21450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53091">
        <property type="protein sequence ID" value="PHQ53091"/>
        <property type="gene ID" value="BLA24_03710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13068">
        <property type="protein sequence ID" value="PPT13068"/>
        <property type="gene ID" value="CYQ11_09335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="309" mass="33303" checksum="A345AB0AB6C91233" modified="2018-01-31" version="1">MNGWTVSDIPGQSGRIAVVTGANSGIGYVTARELARQGARVVLGCRDVTRGKAAEELMREQVPGADVRLAVLDLADLASVRAFAAELPEERLDLLVNNAGVMALPQRRTVDGFEMQFATNHLGHFALTGLLLPRLRAAGPGARVVTVSSGLHFLGTVDPRDLQMDHRYRRWIAYGRSKSANLLFTHELSRRLTAEGSAVVAAAAHPGYAATNLQTAGLRMEERAVAERAVELLNRTVAQSAEDGALPSLYAATAPGVRQDDFIGPRVLLWRGSPTRSVRARWTLDDRASAGLWAASERLTGVTYAWNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGG1</accession>
    <name>A0A2G1XGG1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="11" type="ORF">BLA24_22320</name>
        <name evidence="12" type="ORF">CYQ11_08465</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50291">
        <property type="protein sequence ID" value="PHQ50291"/>
        <property type="gene ID" value="BLA24_22320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12923">
        <property type="protein sequence ID" value="PPT12923"/>
        <property type="gene ID" value="CYQ11_08465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="331"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="584" mass="63140" checksum="9FE40338B3DDC7C3" modified="2018-01-31" version="1">MAQLRLALNQIDSTVGDIAGNAESIVRWTRHSAEQGAHLVAFPEMALTGYPVEDLALRSSFVEASREALHALAARLREEGLGELPVVVGYLDRSEEARPRLGRPAGAPRNAAAVLHRGAAVLTFAKHHLPNYGVFDEFRYFVPGETMPVVRVRGVDVALAICEDLWQEGGRVPGAREAGAGLLLTVNASPYEREKDDTRLELVRKRAQEAGCTTAYLAMTGGQDELVFDGDSIVVGADGSVVARAPQFRETCVVLDLDLPAAPAKAPSGVVADGLRIDHVTLSAEPLPAYEPRFPGVVTEALDDDEEVYEALVTGLRAYVTKNGFRSVLIGLSGGIDSALVAAVACDAVGAEHVYGVAMPSRYSSDHSIADAEDLARRTGLHFRTVPIAPMFDAYMGALGLTGLAEENLQSRLRGTMLMAISNQEGHIVLAPGNKSELACGYSTLYGDSVGAYGPIKDVYKTGIFRLARWRNRAAVERGETPPIPENSITKPPSAELRPGQVDTDSLPDYDVLDRLLELYVDRDQGRAAIVAEGFDAELVTRVLRMVDTAEYKRRQYPPGTKISAKGFGKDRRLPITNRWREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGN2</accession>
    <name>A0A2G1XGN2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">BLA24_20960</name>
        <name evidence="11" type="ORF">CYQ11_09820</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50393">
        <property type="protein sequence ID" value="PHQ50393"/>
        <property type="gene ID" value="BLA24_20960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16460">
        <property type="protein sequence ID" value="PPT16460"/>
        <property type="gene ID" value="CYQ11_09820"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="277"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="214"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="370" mass="38303" checksum="B49C58EEB05220E1" modified="2018-01-31" version="1">MRQEVVGARRIVVKVGSSSLTTAGGGLDADRVDALVDTLAKASGDKEIVLVSSGAIAAGLAPLGLDRRPRDLARQQAAASVGQGLLVARYTASFARYGRRVGQVLLTTDDTSRRAHYRNARRTLDQLLAMGAVPVVNENDTVATDEIRFGDNDRLAALVAHLVRADLLVLLSDVDGLYDGDPSLPGTSRIAEVQGPADLEGVSIGSAGKAGVGTGGMVTKVEAARIAAAAGIPVVLTSATHAADALGGRATGTLFHRTGRRSADRLLWLAHASTPRGALTLDEGAVRAVIEGSASLLPAGIAAVEGEFSAGDPVELRDTGGRAVARGLVAFDAAEIPRLLGRSTRDLARELGPGYEREVVHRDDLVVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGS2</accession>
    <name>A0A2G1XGS2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">BLA24_16475</name>
        <name evidence="7" type="ORF">CYQ11_16810</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50444">
        <property type="protein sequence ID" value="PHQ50444"/>
        <property type="gene ID" value="BLA24_16475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14304">
        <property type="protein sequence ID" value="PPT14304"/>
        <property type="gene ID" value="CYQ11_16810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="288" mass="30778" checksum="59127FDB00BA9175" modified="2018-01-31" version="1">MTIQLSREAAELHALPRGGRRAVVMTMGALHEGHATLVREARRLAGEDGQVVVTVFVNPLQFGPGEDLDRYPRTLEADLLIAERAGADVVFAPSVEEVYPGGEPQVRVTAGPMGERLEGASRPGHFDGMLTVVAKLLHLTLPDLALFGQKDAQQLALIRRMVRDLNFPVEIVGVPTVREGDNLALSSRNRYLSDADRATALEISRALLTAADAAEKGAAPVRRSARAVLDDAAGMEPPLRLDYVALVDPADFTEVPDDYTGEAVLAVAAKVGATRLIDNLPLTVGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGS6</accession>
    <name>A0A2G1XGS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22615</name>
        <name evidence="3" type="ORF">CYQ11_08175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50339">
        <property type="protein sequence ID" value="PHQ50339"/>
        <property type="gene ID" value="BLA24_22615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12872">
        <property type="protein sequence ID" value="PPT12872"/>
        <property type="gene ID" value="CYQ11_08175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="245" mass="26574" checksum="275AFE733282F5E8" modified="2018-01-31" version="1">MGHWLARNIVDPGKLPLLLALTSFVLTFLVTRVITRLIRAGRGPFRNIRPGGLHVHHVVPGVVLMVVGGFGAVAEGQHGVGAAVSAVLFGAGAGLVLDEFALVLHLDDVYWTEQGRKSVEIVVLTAALVTLLLAGFLPFGVNELTPDELHDRGIVVANVSVNFLIALFALAKGKPRMALIGAVVPFVALVGAVRLARPGSPWARRFYRNRPRARRRSRVRAYRHDARWAAVRNRLHDLVAGAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGW7</accession>
    <name>A0A2G1XGW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16700</name>
        <name evidence="3" type="ORF">CYQ11_16585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50477">
        <property type="protein sequence ID" value="PHQ50477"/>
        <property type="gene ID" value="BLA24_16700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14268">
        <property type="protein sequence ID" value="PPT14268"/>
        <property type="gene ID" value="CYQ11_16585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="84" mass="9016" checksum="CA20FA376810635E" modified="2018-01-31" version="1">MAGLAAGHRQRVGPSNAALAAALDRPSERGGRGRRLTFTSPGADGYGLRSLPESCLLRGEKYAAEPDTWRRLSHAFDRLPDPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH32</accession>
    <name>A0A2G1XH32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_17170</name>
        <name evidence="6" type="ORF">CYQ11_16105</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50548">
        <property type="protein sequence ID" value="PHQ50548"/>
        <property type="gene ID" value="BLA24_17170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14198">
        <property type="protein sequence ID" value="PPT14198"/>
        <property type="gene ID" value="CYQ11_16105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="256" mass="27770" checksum="4088BB484E3A59EA" modified="2018-01-31" version="1">MLLGDMTWPDFHHRAQDGYALVPVGAVEPHGPHLPLASDTMISDYFATRLAGTLGSFVTPSIGYGIATEPYRLGGTFPGVISISGTTFINLIQDVLSSLADNGVRKFVIVNSAIDNTGFLCEAVRSFTERAPDARVVIVAWWDVVDEQFRDDLAAETGIARRDDHHAAMVESSLVMHIAPDSTRPDQLTAAPSTSRAPRRMHYHVYPLPSEAATESGIVYTADKASAALGERVADQVTRQLEAAIRLEFNDPPHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH97</accession>
    <name>A0A2G1XH97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin VapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03440</name>
        <name evidence="2" type="ORF">BLA24_17245</name>
        <name evidence="4" type="ORF">CYQ11_16030</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000042">
        <property type="protein sequence ID" value="PHQ53107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004929488.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50561">
        <property type="protein sequence ID" value="PHQ50561"/>
        <property type="gene ID" value="BLA24_17245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53107">
        <property type="protein sequence ID" value="PHQ53107"/>
        <property type="gene ID" value="BLA24_03440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14185">
        <property type="protein sequence ID" value="PPT14185"/>
        <property type="gene ID" value="CYQ11_16030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014447">
        <property type="entry name" value="UCP006909"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006909">
        <property type="entry name" value="UCP006909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="11379" checksum="19FF7C32872740ED" modified="2018-01-31" version="1">MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKQQLDLETLLAEDSTFYGDLFAHVVKWRGDLYLEDGLHRAVRAALQQRQVLHARVLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHB3</accession>
    <name>A0A2G1XHB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17620</name>
        <name evidence="3" type="ORF">CYQ11_15655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50617">
        <property type="protein sequence ID" value="PHQ50617"/>
        <property type="gene ID" value="BLA24_17620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14128">
        <property type="protein sequence ID" value="PPT14128"/>
        <property type="gene ID" value="CYQ11_15655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="185" mass="19766" checksum="41E399CC4CF978E3" modified="2018-01-31" version="1">MNYLRGFIPWIAFAIVPSADWQWGAVLGLAVGIALLAKDQKAGVAAESLILERSTVVYFAVLTAVAFAVPHSPLSHYSGALSLGWLAVTAWATLAVGRPFTTGIAKRQAPPEVWNTPVFRRINVVITAVWAAAFTLTAATLSAVYAAGLDSTVSIPVQVVGFALPAMFTARYPDRVRARLQQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHB9</accession>
    <name>A0A2G1XHB9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage holin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17735</name>
        <name evidence="3" type="ORF">CYQ11_15540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50638">
        <property type="protein sequence ID" value="PHQ50638"/>
        <property type="gene ID" value="BLA24_17735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14107">
        <property type="protein sequence ID" value="PPT14107"/>
        <property type="gene ID" value="CYQ11_15540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13494" checksum="09074E976EDFA758" modified="2018-01-31" version="1">MKNFVVKTIANAAALAVAVWLLKGITLSGENTARKVVTLFLVALVFGAVNFLVKPVVKLLSFPLFILTLGLITLVINALMLLLTSWLAGRLDLAFHVGGFWAALVGGVIISIVAWAMHVILPDEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHI4</accession>
    <name>A0A2G1XHI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17865</name>
        <name evidence="4" type="ORF">CYQ11_15410</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50661">
        <property type="protein sequence ID" value="PHQ50661"/>
        <property type="gene ID" value="BLA24_17865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14084">
        <property type="protein sequence ID" value="PPT14084"/>
        <property type="gene ID" value="CYQ11_15410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017815">
        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
        <property type="entry name" value="mycothiol_INO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="191"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="360" mass="39498" checksum="D027DD5A3A87E6FF" modified="2018-01-31" version="1">MGSVRVAIVGVGNCAASLVQGVEYYQDADPNGRVPGLMHVQFGDYHVRDVEFVAAFDVDAKKVGLDLADAIGASENNTIKICDVPATGVTVQRGHTLDGLGKYYRQTIEESDEAPVDVVQVLKDKQVDVLVCYLPVGSEDAAKYYAQCAIDAKVAFVNALPVFIAGTKEWADKFTEAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVILDRTMQLNVGGNMDFKNMLERDRLESKKISKTQAVTSQIPDRDMGEKNVHIGPSDYVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGVGGPILSASSYFMKSPPVQYFDDEARENVEKFIKGEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL4</accession>
    <name>A0A2G1XHL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18215</name>
        <name evidence="5" type="ORF">CYQ11_15060</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50720">
        <property type="protein sequence ID" value="PHQ50720"/>
        <property type="gene ID" value="BLA24_18215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14026">
        <property type="protein sequence ID" value="PPT14026"/>
        <property type="gene ID" value="CYQ11_15060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041040">
        <property type="entry name" value="3HCDH_RFF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18321">
        <property type="entry name" value="3HCDH_RFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="190"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_RFF" evidence="3">
        <location>
            <begin position="352"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="418"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="505" mass="53879" checksum="65C543CB57E4C8A8" modified="2018-01-31" version="1">MTAIDPGRTVAVVGTGTMGQGIAQVALAAGHLVRLYDAVPGRAEEAARAIAARLGRLVDKGRLDAAGRDAALARLRPAARLAELADSALVIEAILEQLDVKQKLFGELEPVVSEDCLLATNTSSLPVTAVAGALRRPGRFVGLHFFNPAPLLPLVEVVRGFATDEADLERARATVAAWGKTPVTCADTPGFIVNRIARPFYAEAFRVYEERGADPATIDAVLRECGGFAMGPFELTDLIGQDVNNSVTRSVYEAFFHDPKFTPSFAQGQLVQAGLLGRKTGRGWFDHGEGAVRPEPSTAEPCDPPAEISWHAKAPGVCAPLHEMIEEAGVKVVRDRTPQSEWYIGLPDGAMLTLTGGEAATPQCGGTYIYFDLALDYRSCTRVALAPSEKASAADVRAAVGLFQALGKKVSVVGDVPGLIVARTVAMLVDFAEDAAGRGVADREDVDTAMRLGVNYPRGPLEWGEEIGLSRVRNILWGLSQDYPGGRYEPSLSLRRRAAVRESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHM3</accession>
    <name>A0A2G1XHM3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_18275</name>
        <name evidence="12" type="ORF">CYQ11_15000</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50730">
        <property type="protein sequence ID" value="PHQ50730"/>
        <property type="gene ID" value="BLA24_18275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14014">
        <property type="protein sequence ID" value="PPT14014"/>
        <property type="gene ID" value="CYQ11_15000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="499"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="573" mass="59184" checksum="88D781EE348D08E1" modified="2018-01-31" version="1">MSQDGAQGRYAGRSVGGGRYQLRDLLGEGGMASVHLAHDTVLDRNVAIKTLHTELGRESSFRERFRREAQSVAKLTHTNIVSVFDTGEDDLDGSTMPYIVMEYVEGQPLRSVLDADVAQYGAMPADKALKITADVLAALEVSHEMGLVHRDIKPGNVMMTKRGVVKVMDFGIARAMQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGIMLFELLTGRLPFDADSPLAIAYAHVQEEPPVPSSINRSIPPAIDALVARALKKNPNERFPSAEAMRDECARVAGTAQGAPSPIIIAGGPPARSGAGVGSAVFPPVDSSQASVPGPHSVQTPYQPQQAPQGPYNGGYGPSTPPPAYPTPAPAYQTGPSTPAYATPAATSPMPGVPGGSGSSGGRNSKSVLIGSAAVAVLAVLGVIAAIALNGKSGSDDEAGGGKASPAASVAPGGGAGTSGGGAGTASGGTTGGGTQAKHKDGDKSKTIDKEKCTKAYDVYNDKTKKSAPDFRYVYIDSVKECLQAAGWKYRVDQQNENTWGQGTVMSQTPEAGDPFDPKSPSQLFVLTVSTGDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHU1</accession>
    <name>A0A2G1XHU1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">(Fe-S)-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_18625</name>
        <name evidence="8" type="ORF">CYQ11_14655</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50787">
        <property type="protein sequence ID" value="PHQ50787"/>
        <property type="gene ID" value="BLA24_18625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13955">
        <property type="protein sequence ID" value="PPT13955"/>
        <property type="gene ID" value="CYQ11_14655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="762" mass="83792" checksum="3E240E395438075C" modified="2018-01-31" version="1">MQLAAIIVSLVLIAVGVALFGRAILQIYRFVRLGQPVPAGTRTDDPAGRTVTVAKEFLGHTRMNRWGVVGVAHWFVAVGFFSLLLTIVNAIGQLFKADWLLPVIGEWAPYNVFVEFLGTMTALGILTLIVIRQLNRPDKPGRKSRFAGSNTGQAYFVESVILIVGVCIFMLHALEGAQHHVDGYEASFFISYPVVSWLEGVDTSTLQNLTYFFAGLKIATSFIWMITVSLKTDMGVAWHRFLAFPNIWFKREASGDVALGALQPMTSGGKPIDFEDPGEDDVFGVSKVEEFSWKGILDFSTCTECGRCQSQCPAWNTGKPLSPKLLIMTLRDHAHAKAPYLLAGGGKDAEGNEKATEEQLKDVPAAALAEAERPLIGTLEENGVIDPDVLWSCTTCGACVEQCPVDIEHVDHIVDMRRYQVMIESSFPSEAGTMLKNLEKKGNPWGLAKKQRLAWTKEVDFEVPVVGKDIEDLTEVEYLYWVGCAGALEDRAKKTTKAFAELLHMAGVKFAIMGGDENCTGDSARRLGNEFLFQQLGQQNVEMLNMAFGEDADEGVKVEKAKKKIVATCPHCFNTIANEYPQLGGEYEVIHHTQLLQHLVDEGKLVPVTPVEGLITYHDPCYLGRHNKVYTPPREIIAKVPGLRNEEMHRHKERGFCCGAGGARMWMEERIGKRINNERVDEALSLNPDIVSTACPFCLVMLTDSVNGKKNDGKAKESIQVVDVAQLLLESVKTPAAPENGDDGDGDGEPADAPKPDPEPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHV0</accession>
    <name>A0A2G1XHV0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">kynU</name>
        <name evidence="7" type="ORF">BLA24_18735</name>
        <name evidence="8" type="ORF">CYQ11_14545</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50805">
        <property type="protein sequence ID" value="PHQ50805"/>
        <property type="gene ID" value="BLA24_18735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13937">
        <property type="protein sequence ID" value="PPT13937"/>
        <property type="gene ID" value="CYQ11_14545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="121"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="403" mass="42693" checksum="CD6D4C517138DAB5" modified="2018-01-31" version="1">MSDLDLAQEARRLDAADALRAKREEFALDDHDTTVYLDGNSLGALPRAVPARLADVVEREWGRLRIRSWTESGWWTAPERVGDRIGRLVGAAPGQVVAGDSTSVNVFKAVVAAARLAADGDGGRDEILVDAATFPTDGYIAASAARLTGCRIRAVDAGDVASAAGPRTAVALVNHVDYRTGRLHDLPGTTAAVHAAGGRVVWDLCHSAGALPVALDADGVDLAVGCTYKYLNGGPGSPAYLYVRRELQPRFDSPLPGWNSHADPFGMSPQYAPADGAVRGRVGTPDILSLLALEAALDVWDGVAVEAVRAKSLALTDFFLRCVAAYVPGGRLECVTPTAHDERGSQVSLRCADADEVMAELVRRGVVGDFRRPDVLRFGFTPLYTGFADAERAARVLAEVLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHV4</accession>
    <name>A0A2G1XHV4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ORF">BLA24_18890</name>
        <name evidence="12" type="ORF">CYQ11_14390</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50828">
        <property type="protein sequence ID" value="PHQ50828"/>
        <property type="gene ID" value="BLA24_18890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13914">
        <property type="protein sequence ID" value="PPT13914"/>
        <property type="gene ID" value="CYQ11_14390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="505" mass="53896" checksum="F05A324377924726" modified="2018-01-31" version="1">MPRGDGRLNHDLLPGEKGPQDACGVFGVWAPGEEVAKLTYFGLYALQHRGQESAGIAVSNGSQILVFKDMGLVSQVFDETSLGSLQGHIAVGHARYSTTGASVWENAQPTFRATANGSIALGHNGNLVNTAELAEMVAALPRENGRANQVAATNDTDLVTALLAGQTDDDGKPLTVEQAAAKVLPGVKGAFCLVFMDEHTLYAARDPQGIRPLVLGRLERGWVVASETAALDICGATFVREIEPGEMIAIDENGLRTSRFAEAKPRGCVFEYVYLARPDTEIAGRNVYLSRVEMGRKLAAEAPVDADLVIPTPESGTPAAVGYAEASGIPYGTGLVKNSYVGRTFIQPSQTIRQLGIRLKLNPLKEVIKGKRLVVVDDSIVRGNTQRALVRMLREAGAAEVHVRISSPPVKWPCFFGIDFATRAELIANGMTVDEIGKSLGADSLAYISLDGMVEATTIAKPNLCRACFDGEYPMELPDPELLGKQLLETELAGGSDAADALRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI33</accession>
    <name>A0A2G1XI33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1906 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17415</name>
        <name evidence="2" type="ORF">CYQ11_15860</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50880">
        <property type="protein sequence ID" value="PHQ50880"/>
        <property type="gene ID" value="BLA24_17415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16592">
        <property type="protein sequence ID" value="PPT16592"/>
        <property type="gene ID" value="CYQ11_15860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="27993" checksum="5FDCECBAEE8437EB" modified="2018-01-31" version="1">MAALAQVVAHAVPVTAAPASGPLVFRGKGFDTCQAPPLTTLSAWGHSGYGAVGVYYGGRGRACPNQKYLSHRWLTGARDLGWRVLPIFVGSQSPCVLAESKRGYPIGDYPEDQGTDEGREAVRAASALGITSGSPLYLDMEAYDYGDEDCGGTTLAYIRSWSAAVDRRGYVPGFYSSAESGVRHMELSRRAGVSDLPDILWFARWRVPASTDHERALSSGAWQPHRRIHQYAGNVSETYGGRKLTIDRNLIDAPVASIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI56</accession>
    <name>A0A2G1XI56_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate octaprenyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">4-hydroxybenzoate polyprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiA</name>
        <name evidence="5" type="ORF">BLA24_14135</name>
        <name evidence="6" type="ORF">CYQ11_13940</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50934">
        <property type="protein sequence ID" value="PHQ50934"/>
        <property type="gene ID" value="BLA24_14135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13845">
        <property type="protein sequence ID" value="PPT13845"/>
        <property type="gene ID" value="CYQ11_13940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="306" mass="32526" checksum="0BB40A74BBD0C98D" modified="2018-01-31" version="1">MTSAAEGVLSPGPAPSSGKVKAFLRMVLIEHSVFALPFAYIAALTAMFQLDGNIHWIRLLLVTVAMVGLRTFAMACNRIIDREIDARNPRTAGRELVTGAVSVRSAWTGAGVAVFFFLGAAALLNPLCLALAPIAVVPMVVYPYGKRFTNFPHAILGLAQAMGPVGAWLAVTGEWSWDAVILGLAVGVWIGGFDLIFACQDVAADRAHGVKSTPARFGVPAALYGSRACHAVTTGLLVWYALAAHAGVFFWTGLVVVAGAFLYEHSIVKPRDLSRLNRAFFTVNGFIGIALFVCALLDLLVRGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIB4</accession>
    <name>A0A2G1XIB4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ORF">BLA24_14375</name>
        <name evidence="9" type="ORF">CYQ11_13700</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50976">
        <property type="protein sequence ID" value="PHQ50976"/>
        <property type="gene ID" value="BLA24_14375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13802">
        <property type="protein sequence ID" value="PPT13802"/>
        <property type="gene ID" value="CYQ11_13700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="181"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="551" mass="56838" checksum="D38E1E6FDE88BD64" modified="2018-01-31" version="1">MSHAASVHSLWTIAAAEAPKKIPAPHIEYAQLSPTLIVLGAALVGVLVEAFLPRRARYHAQVALAALAMAAAFAAVVVLAAGGYASDKAHIAAMGAVAVDGPALFLQGTVLLVGLVAVFTFAERRLDPAAHGRPVDSFAAQAAAVPGGESERKAVRAGLTTTEVFPVLLFAVGGMLVFPAANDLLTLFIALEVFSLPLYVLCALARRQRLLSQESAVKYFLLGAFSSAFLLFGVALLYGYAGTVTYAGVADVVSGTVRSVDPALAATMGNDALLLIGGAMVLMGLLFKVGAVPFHMWTPDVYQGAPTPVTGFMAAATKVAAFGALLRLLYVVLPGMRWDWRPVMWGVAIVTMLVGAVVAVTQTDVKRLLAYSSIAHAGFILAGVIAVTPDGVSSVLFYLGAYSFVTLGAFAVVTLVRDADGEATHLSKWAGLGRRSPLVAAVFAVFLLAFAGIPLTSGFAGKFAVFKAAAQGGAGPLVVVGVISSAIAAFFYVRVIVLMFFSEPKADGPTVAVPSPLTSTAIAIGVAVTLVLGVAPQYFLDLAGQAGTFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XID3</accession>
    <name>A0A2G1XID3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17760</name>
        <name evidence="2" type="ORF">CYQ11_15515</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50889">
        <property type="protein sequence ID" value="PHQ50889"/>
        <property type="gene ID" value="BLA24_17760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16583">
        <property type="protein sequence ID" value="PPT16583"/>
        <property type="gene ID" value="CYQ11_15515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="210" mass="22818" checksum="9146E6527CCAC722" modified="2018-01-31" version="1">MSRLHLFDLDGTLIHGSAAAVEISRQLGLEPEIAELERAFAEGRLTPPRFAELAVQLWAELTEAQVTAAFEGAPWLAGIRDVWARIRERGERCAVISLSPGFFVERLLDWGADAAHGSLWPAVPFREPLDPAGILDASAKVRIADGLCERFGLSRADCVAYGDSMSDALLFAAVPMSVAVNADHHVRDIASHAYNGRDLREAYELVGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIT8</accession>
    <name>A0A2G1XIT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_15485</name>
        <name evidence="8" type="ORF">CYQ11_12590</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51162">
        <property type="protein sequence ID" value="PHQ51162"/>
        <property type="gene ID" value="BLA24_15485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13615">
        <property type="protein sequence ID" value="PPT13615"/>
        <property type="gene ID" value="CYQ11_12590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="501" mass="51538" checksum="8C38CC61402BCF4B" modified="2018-01-31" version="1">MPDLTTSPDPRRWKALIFIALAQLMVVLDATIVNIALPSAQTDLGISDGNKQWVITAYALAFGGLLLFGGRISDLWGRKRAFVVGLIGFAAASALGGAAVNTGMLLGARALQGVFGALLAPAALSLLAVLFTEAKERAKAFGIFGAIAGAGGGVGLILGGLFTEYLNWRWTFFVNIPFAVVAAAGAIAVIHEPEGSRNPSKLDIPGVVLATLGLVSLVYGFTRAESAGWTAGSTLAMFAASAVLLFAFVLVERKVKAPLLPLRVLTDRNRGGVYVSLGLAAIAMFGLFLFLTFYLQVVRGYSPVKTGLAFLPMIATMIAGSTQIGARLMTRVPARWLMGPGFLLAAAGMTLLTQIDLDTSYTTVVLPGLMLMGLGMGTAFMPAMSLATHGVQPRDAGVASAMVNTSQQVGGAIGTALLNTIAASATTDYLKSHAAGAADPKLLTFQSLVHGYSTAVWWAVGILVVAAGIAVSFITAGHQGGAAVASGDGAGAEEAVPVMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIT9</accession>
    <name>A0A2G1XIT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15355</name>
        <name evidence="4" type="ORF">CYQ11_12720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51143">
        <property type="protein sequence ID" value="PHQ51143"/>
        <property type="gene ID" value="BLA24_15355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13634">
        <property type="protein sequence ID" value="PPT13634"/>
        <property type="gene ID" value="CYQ11_12720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="663" mass="71695" checksum="954F9C0EE39FF363" modified="2018-01-31" version="1">MTTVGPARAGQPQPQPGEPGGEDDGARSADTAGRGAAPARTLTQGRPGWRRPSWALKPDHRRRGRLAVLTGTVPVTLLVAAVLHLVWVLVFANSGGDLAAQDAWAEFALQHPSSAYNLAWYGGMHPVSYSVISPYLMALLGVRSTMMVAGTVSAGLIALLLIRSRAVKRPLWPSLYGAFALTCNAISGRVTFGLGMMFGLAALAAVFAWPVRWRRERRFRWGRAVLAAVMAGLATASSPVAGLFVGVVAAALWLSRRRPAAYALGLTPVLVVALSAWLFPFSGQQPMDFVQAVLPLVSGIFGLLVPRSWRTVRMVAALYTLGVLLVWLIPSQIGTNISRLGMVFGGVVLVAALTGMERPKNWSEVTAAVRAVGSPKKIKEWWAAGDGGPGGAVRLWTVTALALVTVTAWQTATSVGDIVHTTPAASWARELAPLVDRLQRVDAARGRVEVVPARSHREASALAPYVNLARGWNRQADRERNPLFYEDGLLTPDSYRAWLSRWAVHYVVLPTDEPDKAAVGEAKLVGQGQPYLREVWSDDHWRLYQVKDPTPLAEPPAVVDHVDADRLTVTVREAGVVRVRIPYSPWLALVDEKGKPVQPPKAGAHGEPPVNVHGCLTKLVQPQTEDEPEDDWTLLRAPRAGTYRIASPYKLPRGTGCPDDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIW2</accession>
    <name>A0A2G1XIW2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15330</name>
        <name evidence="2" type="ORF">CYQ11_12745</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51140">
        <property type="protein sequence ID" value="PHQ51140"/>
        <property type="gene ID" value="BLA24_15330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13638">
        <property type="protein sequence ID" value="PPT13638"/>
        <property type="gene ID" value="CYQ11_12745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="376" mass="39383" checksum="D1105045AD09FC94" modified="2018-01-31" version="1">MNEHGSTTVGTALWGRAEQQEFRGRVRGCLLGGAIGDALGAGIEFDSLAAVRAAHGPAGVTGYVPAYGRRGAVTDDTQMTLFTAEGLIRAHVRRDTGAWHPPTDIHGAYLRWAATQRDWGPDERVADAGWLAREEWLYARRAPGNACLSGLADTAMGTPEAPKNPDSKGCGAVMRSAPFGLLVGWEPRQVFRLAADCAVQTHGHPTGRLAAGAFAAVVHGVVRGETLEGAVRGALALLAAHAGHEETTAALLRALDAVRQGPPTAERLESLGEGWVAEEALAMGVYCALVAEDVRHGLLLAVNHGGDSDSTGSICGNILGALHGETVLPPGWVVELEGRSTILELADDFAMELTQGPALHGRDAASAAWLARYPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIY5</accession>
    <name>A0A2G1XIY5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_15415</name>
        <name evidence="8" type="ORF">CYQ11_12660</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51151">
        <property type="protein sequence ID" value="PHQ51151"/>
        <property type="gene ID" value="BLA24_15415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13626">
        <property type="protein sequence ID" value="PPT13626"/>
        <property type="gene ID" value="CYQ11_12660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="17"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="438" mass="45021" checksum="E82B193AA241CD0F" modified="2018-01-31" version="1">MTGHLLTDFFIALAIALAAAQTGGALARRVGQPPVVGEIFAGILASPTVLTASVSQHIIPGTVRPLLEGLANIGLAVFMFTVGYEIDFALLRGRTRAALTLATGSVVVPLTAGTLLALPLAGRYAPGDRTGFVLFLGVAMSVTAFPVLARILTDRGLNRKPLGGIALAAAAVGDLAAWIALAAVVAFCGASGQWHVMLLPVYALLLVVVVRPLFRRLTQGAGRGDVMPAALFPALVVGLMLSCAATEWMGVHFIFGAFAFGAVMPKAGPEGLRARLIEQMENTGSHFLLPLYFIVAGTKVDLSGFGAGTLGTLLAVIVVAVASKAVGAYAGARVSGTGHRVALPIAVLMNTRGLTEIVIVTVGLQMHLIDERFYSIMIVMAVVTTAMTGPLLNLVREGTREDAGAEEPVPAAAAPKPAPEPVTSPSSAPEAAAGTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ14</accession>
    <name>A0A2G1XJ14_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">moaC</name>
        <name evidence="7" type="ORF">BLA24_15600</name>
        <name evidence="8" type="ORF">CYQ11_12475</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51181">
        <property type="protein sequence ID" value="PHQ51181"/>
        <property type="gene ID" value="BLA24_15600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13595">
        <property type="protein sequence ID" value="PPT13595"/>
        <property type="gene ID" value="CYQ11_12475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="17276" checksum="3B0BAE9102EECED2" modified="2018-01-31" version="1">MSSAQEHLTHLDDTGAARMVDVSAKEVTARTARASGRVLVSPRVVELLRGEGVPKGDALATARIAGIMGAKRTPDLIPLCHPLAVSGVTVELAVADDAVEIRAAVKTTDRTGVEMEALTAVTVAALTVVDMVKAVDKAAVITDVRVEEKTGGKSGDWARPEAGEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ32</accession>
    <name>A0A2G1XJ32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16065</name>
        <name evidence="3" type="ORF">CYQ11_12010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51264">
        <property type="protein sequence ID" value="PHQ51264"/>
        <property type="gene ID" value="BLA24_16065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13510">
        <property type="protein sequence ID" value="PPT13510"/>
        <property type="gene ID" value="CYQ11_12010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="30615" checksum="A672A5C5A170CECA" modified="2018-01-31" version="1">MRSSNPVFSRRGFSRDNGYAGFGAGPQAGAANPYAANPYAGSPYAQPGNPYAANPYAQGGPDLAQGYPQAPVQTAGRMTIDDVVSRTAITLGLVILAAGAAWALELPVGLGFGAGIVAMVLGLIQSFKAKPTPALILAYAVFEGLFLGVLSQAYNDIARGAPMQAVIGTTAVFAGVLIAYRTRIIRVDRRFTRFVVGASIGFILLMMVNMMFAAFGGGDGLGFRTGGLGILFGVIGVVLGACFLALDFKQIEDGVQYGAPREESWLAAFGLTLSLVWIYTELLRLISILNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK1</accession>
    <name>A0A2G1XJK1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13790</name>
        <name evidence="3" type="ORF">CYQ11_01485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51403">
        <property type="protein sequence ID" value="PHQ51403"/>
        <property type="gene ID" value="BLA24_13790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11743">
        <property type="protein sequence ID" value="PPT11743"/>
        <property type="gene ID" value="CYQ11_01485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305585" evidence="1">
        <location>
            <begin position="33"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="19299" checksum="7BD35408D7A5AB00" modified="2018-01-31" version="1">MSVVRSRLAAVIGTIALITAALTGAATGTASAAADTANASGRWSCSGAPVPDGYVITAYDRNGCNGAGAWYQQPVRDGIWTCSGSPIVTGYVISNYDRNGCSGIGAWYHQLVRDGIWTCAGSPIVSGYVVTNYNRSGCNGIGSWYHQLVRNGIWTCPGSPIPPGYRSTTYNAGGCGGIGAWYTVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL1</accession>
    <name>A0A2G1XJL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51432">
        <property type="protein sequence ID" value="PHQ51432"/>
        <property type="gene ID" value="BLA24_13960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="202" mass="22291" checksum="B1DED112E21A2CFB" modified="2018-01-31" version="1">MESRLTPQEVESRLRRVLGTATPVPAPDRPAEPVMPSFGSQAQWAAYGYHVVRRWLSAVATGRHRAHLSADEIDELAVETTARALNSFRDQARQPIAEPRAAAPELKTAFLTECVRHLPYAHRNRLHTAEHVPFVEFENTDEADLVGMLWGRATTDQAEALRHVACGQDEDVDTDEVVALTPLAIRAAALRYPEAVDPASIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJN0</accession>
    <name>A0A2G1XJN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS fructose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BLA24_16430</name>
        <name evidence="17" type="ORF">CYQ11_11645</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51381">
        <property type="protein sequence ID" value="PHQ51381"/>
        <property type="gene ID" value="BLA24_16430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16497">
        <property type="protein sequence ID" value="PPT16497"/>
        <property type="gene ID" value="CYQ11_11645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="14">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="15">
        <location>
            <begin position="119"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="13">
        <location>
            <begin position="489"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ51381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT16497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="635" mass="64627" checksum="6BF0AFCD454B684C" modified="2018-01-31" version="1">MAAERLTQAAEALGHEMKVETQGSIGAENVLSDNDVGRADGIIIAADKDVDRSRFAGKRVLVVGVAEGIHHPEQLIERVRDAPVYEGDGGTGRGGGGADAGGAAPKGGPGGRGGARGVVYRALMNGVSYMIPFVVVGGLLIAVSLALGGHTTPEGLVIDSSFWRSVNDIGVIGFKLMVPVLSGYIAYAIADRPALVPGMIGGWIANTGELYDSKAGAGFIGAIATGFLAGYVVLWIKRIRVPRFVRPVMPIIVIPVVATTAVGLFFIYVLGKPISWVFEHLTSWLGGLTGASAALLGVVLGLMIAFDMGGPVNKTAFLFGAGLVSGNPEVMGMCAAAIPVPPLGQGLATLLRRGLFTQQERETGLAALFMGFFGITEGAIPFAAARPARVIPANMLGGAVAGAVAGLAAVTDSVPHGGPIVAVLGAVGGVPMFFVAVALGSVVTALATVTLMAVGEGPPARAPRVPVPAGPVGPPAPAGPRRPEEVLSGYLTGRTVKVELAAGRKDEAVRELAELLAVTGRVTDVDALVAAALAREEVGTTGLGEEIAIPHAKTDAVSAPVVGFARSSEGVEWGALDGTRARLIFMIAVPEAAAGDEHLRILALLARKLLDAGFRGRLLAAADTEAVMGVLGEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJT8</accession>
    <name>A0A2G1XJT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13215</name>
        <name evidence="3" type="ORF">CYQ11_00935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51470">
        <property type="protein sequence ID" value="PHQ51470"/>
        <property type="gene ID" value="BLA24_13215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11652">
        <property type="protein sequence ID" value="PPT11652"/>
        <property type="gene ID" value="CYQ11_00935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6415" checksum="3D190527D2C12CF8" modified="2018-01-31" version="1">MTVVLGENDSLSGRGTGPPQDLVVRGGMSAAAEEVALATARRTAPRPVPMLRASRVRDRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJW4</accession>
    <name>A0A2G1XJW4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13495</name>
        <name evidence="3" type="ORF">CYQ11_01215</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51517">
        <property type="protein sequence ID" value="PHQ51517"/>
        <property type="gene ID" value="BLA24_13495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11699">
        <property type="protein sequence ID" value="PPT11699"/>
        <property type="gene ID" value="CYQ11_01215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="293" mass="32863" checksum="A184A9554015EC5E" modified="2018-01-31" version="1">MSPVIDLGAFLRTRRARLRPEDVALPDLGGRRRVAGLRREEIAQLAGVSVDYYIRIEQGRAANPSSDVLNALARALRLDEDETRHLHRLAQPRAVTRPAPRARPGQQQPRPMLLRLLEELRDVPAVVMGRRMDVLAWNAAASALLGDYASLEPSERNIPRITFLDPASRQLFTDWRACARENVAYLRWEAGRYPDDPQLARLIGELSARSEDFRRWWAEHPVQDKTSGTKRFHHPVVGDLALTYDTLRAADDPDQALITYAAAPGTPSHDALKMLLAWAAPTATTTPHPARPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK63</accession>
    <name>A0A2G1XK63_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="12" type="ORF">BLA24_12365</name>
        <name evidence="11" type="ORF">BLA24_12590</name>
        <name evidence="10" type="ORF">BLA24_13085</name>
        <name evidence="13" type="ORF">CYQ11_17445</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000138">
        <property type="protein sequence ID" value="PHQ51670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51622">
        <property type="protein sequence ID" value="PHQ51622"/>
        <property type="gene ID" value="BLA24_13085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51660">
        <property type="protein sequence ID" value="PHQ51660"/>
        <property type="gene ID" value="BLA24_12590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51670">
        <property type="protein sequence ID" value="PHQ51670"/>
        <property type="gene ID" value="BLA24_12365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14415">
        <property type="protein sequence ID" value="PPT14415"/>
        <property type="gene ID" value="CYQ11_17445"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="16719" checksum="5204BD5E98B63DBD" modified="2018-01-31" version="1">MDSEPLRPVLPLVGVGTDVHAFEEGRELWCAGLLWEGASHGLAGHSDGDVAAHAACDALFSAAGLGDLGAHFGTDRPEWSGASGATLLAEAARIVREAGFEIGNVAIQVIGVRPKIGKRREEAQKALSAAVGAPVAVSGTTTDGLGLTGRAEGLAALATALVYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK89</accession>
    <name>A0A2G1XK89_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neutral metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_12505</name>
        <name evidence="14" type="ORF">CYQ11_17530</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51647">
        <property type="protein sequence ID" value="PHQ51647"/>
        <property type="gene ID" value="BLA24_12505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14429">
        <property type="protein sequence ID" value="PPT14429"/>
        <property type="gene ID" value="CYQ11_17530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033837087" description="Neutral metalloproteinase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="12">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="10">
        <location>
            <begin position="217"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="11">
        <location>
            <begin position="363"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="538" mass="56316" checksum="0E13DA1B78B07030" modified="2018-01-31" version="1">MRSVTSTSRKNSVRAAALVASAAMVVIGVQTGSASAAVDSADSGQQLALSAGQRASAIQDAQGVASSTAAKIGLGGKEKLVVRDVVKDADGTVHTRYERTYEGLPVLGGDLVVHEKKNGARDVTKATDADIAVPTTTPSVAPSQAKKSALGVAADNKNSKADGQTPRKVVWAAKGKPVLAYDTVVTGVQKDGTPSKLHVVTDANTGKTLFQDETIETGTGTSTYSGNVSLTTTKSGSGYSLTDGSRGGHKTYDLNQGTDGTGALFTNSSDVWGAGRQKAGVDAHYGAAVTWDFYKNVLGRSGIKGDGKGAYSRVHYGNGYVNAFWDDDCFCMTYGDGENNAHPLTSLDVAAHEMSHGVTSATANLRYSGESGGLNEATSDIFGTAAEFYAKNSTDPGDYLIGEKIDINGDGTPLRYMDKPSKDGGSKDYWTSSLGNLDVHYSSGPANHFFYLLSEGSGSKVIDGVSYNSPTYNNSKITGIGRDKATKIWYKALTTYFTSTTDYKAARTATLKATADLYGSTSNEYKTVAATWSAINVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKN3</accession>
    <name>A0A2G1XKN3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12000</name>
        <name evidence="3" type="ORF">CYQ11_03240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51798">
        <property type="protein sequence ID" value="PHQ51798"/>
        <property type="gene ID" value="BLA24_12000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12044">
        <property type="protein sequence ID" value="PPT12044"/>
        <property type="gene ID" value="CYQ11_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="337" mass="37838" checksum="6ADA89C0ED042C21" modified="2018-01-31" version="1">MAETMELTVGERTVRLSNPGKVYFPRRGFTKYDLAHYYLSVGDGILRALRDRPTTLERYPDGVEGESFFQKRAPKNLPEWIPTGRIAFPSGRYADEICPTEVAAVLWAANLGCVTFHPWPVRRADTDHPDELRIDLDPQPGTGYADAVRAALELREVLDGLGLTGWPKTSGGRGLHVFVPIRPEWTFVQVRRAAIAVARELERRAPERITTAWWKEERGEKIFVDYNQTARDRTIASAYSVRPRPNATVSAPLHWREVADAVPEDFDLATMPARFAEVGDPHAGMDARPCGLEAALDLAARDEREHDLGDLPYPPEHPKMKGEPKRVQPSRARKGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKR8</accession>
    <name>A0A2G1XKR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl--CoA ligase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12205</name>
        <name evidence="4" type="ORF">CYQ11_03445</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51833">
        <property type="protein sequence ID" value="PHQ51833"/>
        <property type="gene ID" value="BLA24_12205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12081">
        <property type="protein sequence ID" value="PPT12081"/>
        <property type="gene ID" value="CYQ11_03445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="397"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="467" mass="51288" checksum="3A195B83745EA317" modified="2018-01-31" version="1">MSAKIFARDAVRTLPEFERDALLVAQVLRERGVGPGDRVTLKAGNSAAWVASLLALMHIGASVVLVDQQEHLEETRRIILRTGTKLVLCDEDAPLDDEQEAIHVYELLVAAAGRVPTEERLSFDAWRERPDGLIMWTSGSTGSPKGVVKSGGKFLKNLERNADQVGHREDDVLLPLLPFAHQYGLSMVLIAWIRQCSLVIAPYRRLDHSLLMAAQSGATVIDATPASYRSMLNLVTRKPSLRPALADARMFCVGAAPLDTPLVDQYIQEFGMPLLDSYGSTELGNIAFATLDNPVACGQVMDGIRLRVVDDEGRDVAAGQAGELEVDTPDGMEGQLAEDGSLVPTPAGWQRTGDLGYLDAVGNLYVLGRKYAVHRMGYTLYPELIERSVAAKGCSARIVALPDERRGAQLVFFVEDGEGLGVAHWRDRLREMLAAYERPDRVLVLDRFPLNRNGKPDKRQLERLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKT4</accession>
    <name>A0A2G1XKT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_12250</name>
        <name evidence="11" type="ORF">CYQ11_03485</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51842">
        <property type="protein sequence ID" value="PHQ51842"/>
        <property type="gene ID" value="BLA24_12250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12088">
        <property type="protein sequence ID" value="PPT12088"/>
        <property type="gene ID" value="CYQ11_03485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1686"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3222"/>
            <end position="3297"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4984"/>
            <end position="5059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1721"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3257"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="5019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="5143" mass="537217" checksum="B360E476F1E7E54F" modified="2018-01-31" version="1">[encoded data, 5143 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU7</accession>
    <name>A0A2G1XKU7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11140</name>
        <name evidence="3" type="ORF">CYQ11_16855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51884">
        <property type="protein sequence ID" value="PHQ51884"/>
        <property type="gene ID" value="BLA24_11140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14313">
        <property type="protein sequence ID" value="PPT14313"/>
        <property type="gene ID" value="CYQ11_16855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="24971" checksum="D46284F895BD07D9" modified="2018-01-31" version="1">MAESPPPRPPRPRRRWRQWYECVLGWPTAPATAVRPMGLLTGVRFDALGVPEEAGFAVLGRVPATGPVALDRRAGRMWFLTAQGSADELPELLGWLDWGGVALGLTALGTGGRIVAPAPWEGRSAAGRRQEALEGPGAVEAVWVRPPEPGCEVERTLPETGLGGDVGAPDLVRLVSTAATECHRSRLLRAGRARRDQPPENRPGGPGDQAQDQALAFSYASRISAGTRPRSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL62</accession>
    <name>A0A2G1XL62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10520</name>
        <name evidence="2" type="ORF">BLA24_13910</name>
        <name evidence="4" type="ORF">CYQ11_01605</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000122">
        <property type="protein sequence ID" value="PHQ51975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51422">
        <property type="protein sequence ID" value="PHQ51422"/>
        <property type="gene ID" value="BLA24_13910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51975">
        <property type="protein sequence ID" value="PHQ51975"/>
        <property type="gene ID" value="BLA24_10520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11763">
        <property type="protein sequence ID" value="PPT11763"/>
        <property type="gene ID" value="CYQ11_01605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="294" mass="30506" checksum="A11EA4102425B973" modified="2018-01-31" version="1">MDTNVSVLGLGRMGAALAGAFLAAGHRTTVWNRTAGTADTLVEKGAVKAGSAAEAVAASPVTVVCLASYEAVLEVLDPLAGELAGRSLVNLTSGSPPHARERAAWARRYAAEYLDGVVMTTSSSVGNGDHLVLYSGSRAAFDDHRDVLAALAEPVHLGTDAALASVYDTALLGLMCSTLTGWLHGVALVGADGPGGNETATAYTDVATRWMRSVGGLMTAYARQIDAGRYPGGDLTLDLHRSTTDLLVHASELRGVETGLPRLLRDLTGRATAAGHGDDSYARLIEFMRTDDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLH0</accession>
    <name>A0A2G1XLH0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="5" type="ORF">BLA24_09165</name>
        <name evidence="6" type="ORF">CYQ11_27775</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52085">
        <property type="protein sequence ID" value="PHQ52085"/>
        <property type="gene ID" value="BLA24_09165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16165">
        <property type="protein sequence ID" value="PPT16165"/>
        <property type="gene ID" value="CYQ11_27775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="25203" checksum="1FD545DFEF41CA70" modified="2018-01-31" version="1">MVTTTGLAAAPPLPEGSAPAPGPAAEAPVAGDGHALAALLVLADGRFPAGGHAHSGGAEAAVKAGRITDGASLAAFCGGRLHTTGLTAAALAAAAAAGLDPLGLDAAADARTPSSALRTASRRLGRQLTRAARATWPSAALDALAAARPRGAHQPVVLGLVARAAGLSPLAAAYAAAYESVSGPATAVVRLLSLDPFEASAVLARLAPDLDEVARTAAEAARRALDEGPHVLPAASAPLLDITAEQHAAWPVRLFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMA0</accession>
    <name>A0A2G1XMA0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07945</name>
        <name evidence="3" type="ORF">CYQ11_00380</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52372">
        <property type="protein sequence ID" value="PHQ52372"/>
        <property type="gene ID" value="BLA24_07945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11574">
        <property type="protein sequence ID" value="PPT11574"/>
        <property type="gene ID" value="CYQ11_00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="30948" checksum="AEAAF2CDD35CBB10" modified="2018-01-31" version="1">MIETSDEQTPLTPVTVLGLGPMGRALASAFLNAGHQVTVWNRTSGKAGDLLDHGAVAAGSVQEAVRAGQVIIVCLIDYDAVQATLEPSQADWENRCLVNLTSGEPAQARQMSEWASSRGIDYLDGAILTPTPAIGTPSAAVLFSGAHDVYEAVQETMSAVGGAAVHLGDDPGQASAYEVALLDIFATSVNGIVHAFALASAEGIEPERFAAFATGIGGLLPEMITRFARQIQTGHYPGDRSTIASAASGITHIINTATTHGIDVGMLTAAKGIIDQAVADGYGTQGLARLSTMLHTRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMA2</accession>
    <name>A0A2G1XMA2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07915</name>
        <name evidence="3" type="ORF">CYQ11_00350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52367">
        <property type="protein sequence ID" value="PHQ52367"/>
        <property type="gene ID" value="BLA24_07915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11570">
        <property type="protein sequence ID" value="PPT11570"/>
        <property type="gene ID" value="CYQ11_00350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7795" checksum="B2A9CFEEDA132DF6" modified="2018-01-31" version="1">MLVRKMHEAGVRSEHAYMAAMASIGLSFLSWATSAKTESAGIDRADRWGIFVGEWAPTFFGLGLALAQYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMI9</accession>
    <name>A0A2G1XMI9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07870</name>
        <name evidence="2" type="ORF">CYQ11_00305</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52359">
        <property type="protein sequence ID" value="PHQ52359"/>
        <property type="gene ID" value="BLA24_07870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11561">
        <property type="protein sequence ID" value="PPT11561"/>
        <property type="gene ID" value="CYQ11_00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="352" mass="38687" checksum="17C9B4FDDED2FE72" modified="2018-01-31" version="1">MARDGINKRELNKWARNLVKETNKSVERAQRRNPLCVSAQLNSTASVIPAGEVTESSGNQARLLLWLDEQARQNPSRYIDVTRFVEEQQLHDEDTSVLAFELEQRDLVTIARTFGGTPEVHLTDAGRAAIHRLKKLRLDRAARLRYTMDAFHQWLFATAGDQKPINPALFLDTPAAYFAGSEITGTELHEALAHLSQHKLIEHIDTEPATVAITPQGVSCAPAGGSVQDHVNQPRPGTTYNNYMPNAKGVIIGEQQHLTQNNTDGVDPTLFAQLTGYIGQVSTTLGMSETDRVELERVAQDLHAEAASGNPEPGRLRQFATQLKDKLLEADTTIAATMGVQMADQALAALVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN37</accession>
    <name>A0A2G1XN37_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_06040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52662">
        <property type="protein sequence ID" value="PHQ52662"/>
        <property type="gene ID" value="BLA24_06040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="124"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="560" mass="60684" checksum="8DDC54B5D389596D" modified="2018-01-31" version="1">MVASRTRYDLRSGLKYRAPLPDSAMSRHAPSGGRRAHRKPLQVEESVTTTSRPTGKSLPTEGQPDDPAQAEAASGLPPLAWKPVTAVAAVLGLLLLATSGRWGYQGDELYFLGASEHLSWGYADNPPLLPLLAGAMDSLFGGSLVGLRLPSTILAATGTLFAALIARELGGETKAQLRTAVAWAAVPLVMIVGHALSASTVDLFAWTAVTWLLVAWVRRQDDRLLLWIALVSVVSMQAKYSIVFLWVAVGISALAVGPRRLLRRPMLWVGAAVVFATVIPGLLWQADHGWPQLHMADVFRRESAGPVAYVGVALFLAGLLLVVLSAHGLWQLLRSPDLRPYRFLGWSFVGLFVFFLVTGGRPTYVAGLFPLLWAAGAVRMQRGTPAKWWRWAVSWPVFGLVAALSIVTSLPVLPRSDDDPPVAGTDNNPQAAETVGWDDLVTAVEKATQSVPAGEREHAAIVTEYYTEAGALEHLGRGEDLPKVYSAHRGYWYFGGPSDDATTTIFVGSDREELLKRFSDVREAATTAGKGNAVAGTKVWICKGNRQPWSQMWPDMGHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN46</accession>
    <name>A0A2G1XN46_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07315</name>
        <name evidence="2" type="ORF">CYQ11_27470</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52569">
        <property type="protein sequence ID" value="PHQ52569"/>
        <property type="gene ID" value="BLA24_07315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16107">
        <property type="protein sequence ID" value="PPT16107"/>
        <property type="gene ID" value="CYQ11_27470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="18746" checksum="297D154DA23C13F3" modified="2018-01-31" version="1">MTVYQVLLVGGCSGVGKTTVAWEVSALLQAEGVAHCLVEGDFMDQIHPAPAGDLDRSLITERNLAAVWANYAALGQRRLIYTNTVSILEGGLIRRAMGGRPLDVTRVLLTAEHAVVAERLRLRETGSQLAPHLERSAKAALRLDREAPPGTVRVATDGRTVGDVARRVREASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN82</accession>
    <name>A0A2G1XN82_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000077">
        <property type="protein sequence ID" value="PHQ52641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52641">
        <property type="protein sequence ID" value="PHQ52641"/>
        <property type="gene ID" value="BLA24_06350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4240" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="172" mass="19498" checksum="D528B07D5AC0A6CE" modified="2018-01-31" version="1">MMDETEFWELIDTARDAAEETPDQADVLVESLTQLEPEDVLDFARHFESRYNRAYLWDLWGAAAVLLNGASDDVFDYFRCWLIGQGREVFEGAVHDPDQLAELLDDFDDEVDGDGEDLGYAADEAYEQLTGTETPDLGLAPQPAEPLGTPFDLEDEAALAERFPRLWERFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNE5</accession>
    <name>A0A2G1XNE5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1996 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05780</name>
        <name evidence="5" type="ORF">CYQ11_02255</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52774">
        <property type="protein sequence ID" value="PHQ52774"/>
        <property type="gene ID" value="BLA24_05780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11875">
        <property type="protein sequence ID" value="PPT11875"/>
        <property type="gene ID" value="CYQ11_02255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758887" evidence="2">
        <location>
            <begin position="37"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="220"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="462" mass="47939" checksum="11F961851C8AE584" modified="2018-01-31" version="1">MTPTTRHGHKRRVPVKVRALLATAALLLGGGGTALVAADASAGGTHRPAAGGAQEQAAATATTIACPDVGDRLQDVPAPARQQVSAGLAELDAQIARAYEKAAAPGGDSGAVLGELKQQRSTTIGRMADAIGEKSARPAELTELSACRTQQVRTDAARGASGAPVLGRPMPGGPSPADFADIRTAPARPRPATRAGGSAGTFTSACGRNENGHFNSDNVIVTPGVSNGAHHTHDYVGNLSTNAFSTDASLAAAGTTCTNGDLSTHYWPVLRLLDGKAAPDADKPGGGHDGNMGKVLRPSSVTLQFRGSPVAKVSAMPRFLRVITGDAKAFTSGPANANASWSCVGFEERQFKDKYPICPRGAEVVRTLAFQSCWDGRSTDSANHRTHVAFARQDGSCPRGFRAVPQLVQRITYQVPSGTPFAVDSFPEQLHKPVTDHGDFINVMPDALMAKAVACVNSGRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNP1</accession>
    <name>A0A2G1XNP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04735</name>
        <name evidence="2" type="ORF">CYQ11_28800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52875">
        <property type="protein sequence ID" value="PHQ52875"/>
        <property type="gene ID" value="BLA24_04735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11466">
        <property type="protein sequence ID" value="PPT11466"/>
        <property type="gene ID" value="CYQ11_28800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="8685" checksum="67E516AAF68F5905" modified="2018-01-31" version="1">MTYRIRMDPSLHHTYKGLPDEARRDFAVCLLDTLTDPIAHSAPYGIDDGIMRTIARGRVAGVILVGQDTVTLVQLTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR3</accession>
    <name>A0A2G1XNR3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_04590</name>
        <name evidence="7" type="ORF">CYQ11_28940</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52856">
        <property type="protein sequence ID" value="PHQ52856"/>
        <property type="gene ID" value="BLA24_04590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11488">
        <property type="protein sequence ID" value="PPT11488"/>
        <property type="gene ID" value="CYQ11_28940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="332" mass="36265" checksum="2BA0A53EE659FC49" modified="2018-01-31" version="1">MSTPPAVRTATALLRAEDLVKRYPVRHGLTRRLAGHVAAVNGVSLEVRAGETLGLVGESGCGKSTLGRMLTRLIEPTSGSVCFDGRELCGLGDDALRPVRRELQMIFQDPFSSLNPRQTVRQILTAPFRYQHLPPGEPVEALLERVGLRPEHARRHPHEFSGGQAQRIGIARALALRPRLVVCDEPVSALDVSVQAQILNLLADLQDELGLAYVFIAHDLGVVRQISTRIAVMYLGTIVEIAGRDALFARPAHPYTHALLAAVPLPDPDAERNRERVVLRGDPPSPLQPPSGCPFRTRCPRADERCAAEKPVLRDLAPGHRVACHHPEETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNX1</accession>
    <name>A0A2G1XNX1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_05115</name>
        <name evidence="12" type="ORF">CYQ11_28415</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52932">
        <property type="protein sequence ID" value="PHQ52932"/>
        <property type="gene ID" value="BLA24_05115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11407">
        <property type="protein sequence ID" value="PPT11407"/>
        <property type="gene ID" value="CYQ11_28415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03914">
        <property type="entry name" value="UDG_fam_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="51"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT11407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="226" mass="23317" checksum="F9CC32214F1063E1" modified="2018-01-31" version="1">MARAGQADGAEPEPYDAGPFVPAGGDLRALREAAAGCRGCPLHRAAGQTVFGSGDASARVVLLGEQPGDQEDRQGRPFVGPAGGVLMRAVDEAGIDPALTYVTNAVKHFKFEPSPRGKRRIHKAPNLREISACKPWLAAELRLVGPEVVVTLGATAGKALFGSSFRVAEKRGAALPMPPVDGQESPGTALVATIHPSAVLRADDAGRAAAYAGLVSDLKVAARLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP08</accession>
    <name>A0A2G1XP08_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05105</name>
        <name evidence="5" type="ORF">CYQ11_28425</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52931">
        <property type="protein sequence ID" value="PHQ52931"/>
        <property type="gene ID" value="BLA24_05105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11408">
        <property type="protein sequence ID" value="PPT11408"/>
        <property type="gene ID" value="CYQ11_28425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="461" mass="48739" checksum="015FCE37FB982223" modified="2018-01-31" version="1">MSLPGPGSRRTAPEAPGAVTDTLVVGAGMAGLYAARELHRAGRDVVVLEVRDRVGGRVWSDRWEGGTIDLGASWIHGVEGNPVADLAREAGAGTLVNNAGTLDYGVRAGAVHYGADGRRLTPAECRERQRDHEAVSAGLFALARTADPDESLASGLRRALADSGLTPARALRVLHARCRMAEDDWGAGAEELCLSGLVTGQDHEGDEVVFPDGYGQLTRHLATGLDVRLGHRVTRVEHGDGGVTVHIDGQGVLTARRALITLPLGVLKEGSVTFDPALPEPKLRAVERLGMGLYDKLFLRFPRPFWDESEVIGQEGTPHGAFANWYDLRHVVGAPVLLALNGGPVARRLQDLDDTAVVRAALNCLRGLYGERVEEPSAHRVTRWGTDPYARGAYSYPAVGSLPGDHDALAAPVGGRLHFAGEATSADHSSTVHGAVLSGLREARRILGTDGGTGGSADTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP20</accession>
    <name>A0A2G1XP20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000068">
        <property type="protein sequence ID" value="PHQ52995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52995">
        <property type="protein sequence ID" value="PHQ52995"/>
        <property type="gene ID" value="BLA24_04390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="220" mass="22398" checksum="6E1C0983E5C70431" modified="2018-01-31" version="1">MNSCQPEPATILLGRPRSPVLPRSSSKIGEQEPERLNEGDGVTCGALEGSAEGVDGAAEGLADGAGRLPSVVPLPGPVDGRVSSPGRPIGEGAAEGAAEAAGLPSAAGACSAAWAGEATSCDRGPREVRTAPGAASRATGPTAAMTAAVARVRRNFIDPLPEANDYAYMTGRSRERLWLTEKCRAPCERTHCRPAEGLRRDHGEGPRAGSAGACGRPRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP44</accession>
    <name>A0A2G1XP44_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000065">
        <property type="protein sequence ID" value="PHQ53007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53007">
        <property type="protein sequence ID" value="PHQ53007"/>
        <property type="gene ID" value="BLA24_04310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="287" mass="31657" checksum="739E94E1A63E5A9D" modified="2018-01-31" version="1" fragment="single">MPPLLDPNDLYAADRPNALSPVVKDFPSRVYVPNTESDSVSVIDPKTYKVIETIPVGEQPQHVVPSWDLKTLWVNNDRGHTLTPIDPATGKAGKPVDVHDPYNLYFTPDGKYAVVMASMDRELVFRDAHTMKRMKTEHVDCLGVNHADFSPDGRYFIVSCEFSGELLKVDTARMKVIAKQKLPFDGAMPQDVKISSDGKTWYVADMMADGLWVLDGDKFTEPSLMPTGKGAHGLYVSRDSKSMYISNRGEGSISVLDLPSRKLVKKWELPEGGSPDMGGVSADGKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPA2</accession>
    <name>A0A2G1XPA2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_03900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000056">
        <property type="protein sequence ID" value="PHQ53067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53067">
        <property type="protein sequence ID" value="PHQ53067"/>
        <property type="gene ID" value="BLA24_03900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="136" mass="15742" checksum="AA998F90A5105913" modified="2018-01-31" version="1" fragment="single">MCGRYAASRRPEDLAGLFGVEKWEPEETLAPDWNVAPTKSVHAVLERPLKDAADRRPVRQLRTLRWGLVPSWARSPEGAAKMINARAETVHEKPSFRRAFESRRCLLPADGYYEWVTGAQERELEEQGRRKRTRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPC2</accession>
    <name>A0A2G1XPC2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_03780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000052">
        <property type="protein sequence ID" value="PHQ53087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53087">
        <property type="protein sequence ID" value="PHQ53087"/>
        <property type="gene ID" value="BLA24_03780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="240" mass="25001" checksum="C20E5CD4CB767A3F" modified="2018-01-31" version="1" fragment="single">MAENPRRRAGRDPCGLLPPTGAHGASFAGWRAALPAGTALALVAPPGRGSRMDEEPVTGMAAYADAVAAGLRTAARGRRLVLVGVSLGALLAYETCRRLLDADVPVARLCVVAGQTPGDFHGDGGELTADDARAFVLRTGLTDPELLADPDFEDVLLPRSSPTCACPAATTAGTRPRCPCGCGRCGPPTTSTSAPGRGEVGRLDHPRLRRDRRRGRSLRPPGGARGGRRRLPGRARPHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPC3</accession>
    <name>A0A2G1XPC3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000052">
        <property type="protein sequence ID" value="PHQ53082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53082">
        <property type="protein sequence ID" value="PHQ53082"/>
        <property type="gene ID" value="BLA24_03765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="202" mass="22170" checksum="E744DE823427983E" modified="2018-01-31" version="1">MGRAAGRPARGQGHRTRLPRRPGGRPRTRRCRRSARRPQDRRRLPGTGPGDPRAAPAAHDRGGRAARRPGRTGSRPVPHPRRAPRPPRPPHRGTATPGPAREPDEDDLFHIVYTSGTTGNPKGVRISRRSVRNRLEWMWRDHPFTEGAVLAVQKSVALVASPGSCWAACSRASPRWSSAATRCSTRRCSPPPSPGRRSPTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPJ4</accession>
    <name>A0A2G1XPJ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AA_permease_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_03870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000055">
        <property type="protein sequence ID" value="PHQ53069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53069">
        <property type="protein sequence ID" value="PHQ53069"/>
        <property type="gene ID" value="BLA24_03870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease_C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="107" mass="11247" checksum="F92C9A261165B3EF" modified="2018-01-31" version="1" fragment="single">VLSVLASLWLMLNLPAETWARFAVWMLLGVVVYFVYGRRNSRVRQGGAAGAAGSLTATPRPSGRPRPTRDAGGRLAPGPRGPTGARTAAPPPRRPAPSPARAAPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT5</accession>
    <name>A0A2G1XPT5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">BLA24_02370</name>
        <name evidence="16" type="ORF">CYQ11_04735</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53201">
        <property type="protein sequence ID" value="PHQ53201"/>
        <property type="gene ID" value="BLA24_02370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12293">
        <property type="protein sequence ID" value="PPT12293"/>
        <property type="gene ID" value="CYQ11_04735"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="227"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="159"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="221"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ53201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT12293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="431" mass="46496" checksum="A3E749CA0BB6F9D4" modified="2018-01-31" version="1">MTAVQSWYPFGDGEADVLALDSVERAVADIAAGRPVVVVDDADRENEGDLVVAAEKITPEIVAFMMSECRGLICVPMEEADTDRLDLPQMVDHNTESMRTAFTVSVDASRAHGTDTGISAADRAATIRLLADPAAVPADFVRPGHVFPLRARPGGVLVRNGHTEAGVDLARLAGLRPAAAIVEIAGEDGAMLRLPELVPFARKHGLSIISIEDLIAYRKSSEPTVRREAETRLPTAHGDFRAYGFRSTVDGVEHIALVAGDLGDGEDVLVRVHSECLTGDVFGSLRCDCGPQLQASLERVSVEGRGVVLYLRGHEGRGIGLLPKLRAYELQEDGRDTLDANLELGLPADARDYACGAQILADLGVRSLRLMTNNPDKTAALIRHGLKVTGREPMPVQAGEHNLRYLRTKRDRMGHDLPWLETERGSACGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPU8</accession>
    <name>A0A2G1XPU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02430</name>
        <name evidence="3" type="ORF">CYQ11_04795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53211">
        <property type="protein sequence ID" value="PHQ53211"/>
        <property type="gene ID" value="BLA24_02430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12303">
        <property type="protein sequence ID" value="PPT12303"/>
        <property type="gene ID" value="CYQ11_04795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="21347" checksum="7C4F408DD79648B7" modified="2018-01-31" version="1">MSSPHLLLTGDRLALGMPREAMLAEYHKWETDPGTILGRGSRFPQAWEAHAEEWDRQLDDRDHARFEIVRLKDKQAIGLTALRVHPRERRAEFTIFLAPPQRGKRFAEEATRLTLDWAFHLGALRAVWLKVLEPNRAGITAFEKAGFRPAGRFRRSGHWLGQPVDEVLMDALLEDFPGPSAMCTALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPY1</accession>
    <name>A0A2G1XPY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yajC</name>
        <name evidence="10" type="ORF">BLA24_02880</name>
        <name evidence="11" type="ORF">CYQ11_05175</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53273">
        <property type="protein sequence ID" value="PHQ53273"/>
        <property type="gene ID" value="BLA24_02880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12368">
        <property type="protein sequence ID" value="PPT12368"/>
        <property type="gene ID" value="CYQ11_05175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758436" evidence="9">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="163" mass="17301" checksum="F839A990DDBA1A0E" modified="2018-01-31" version="1">MNIVTLLPFIVLIGAMFLMTRSAKNKQRQAAQMRNEMQPGTGVRTIGGMYATVKEINEDTVLLEVAPGVHAIYAKNAIGAVLEDAEYNRIVHGLEPEDAPVVPDDASSLTDADAPAEKKIDLGKDAAPAAADEAGKADKADEKSAEAEAQPKDVKRDGDTDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ49</accession>
    <name>A0A2G1XQ49_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl carrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methoxymalonate biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02635</name>
        <name evidence="4" type="ORF">CYQ11_04930</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53340">
        <property type="protein sequence ID" value="PHQ53340"/>
        <property type="gene ID" value="BLA24_02635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16358">
        <property type="protein sequence ID" value="PPT16358"/>
        <property type="gene ID" value="CYQ11_04930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="9946" checksum="B25D9425A6FA1912" modified="2018-01-31" version="1">MTTTAPVTAEVIESALLDFLESRTKATVEKDQDLFSSGLVSSMFAMELVVHLEGAYGIAIVGPDLKLDNFRTVRGMSALVLRLRAEAAADSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ68</accession>
    <name>A0A2G1XQ68_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="13" type="ORF">BLA24_02965</name>
        <name evidence="14" type="ORF">CYQ11_05265</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53289">
        <property type="protein sequence ID" value="PHQ53289"/>
        <property type="gene ID" value="BLA24_02965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12385">
        <property type="protein sequence ID" value="PPT12385"/>
        <property type="gene ID" value="CYQ11_05265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="274"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="658" mass="74333" checksum="7729A88DD89CCB5A" modified="2018-01-31" version="1">MSDVRVIIQRDSEREERVVTTGTTAADLFAGERTVVAARVAGELKDLAYVVADGQEVEPVEISSEDGLNILRHSTAHVMAQAVQELFPEAKLGIGPPVKDGFYYDFDVEKPFTPEDLKLVEKKMQEIQKRGQRFSRRVVTDEAAREELADEPYKLELIGLKGSASHDDGADVEVGAGELTIYDNLDAKTGELCWKDLCRGPHLPTTRFIPAFKLMRNAAAYWRGSEKNPMLQRIYGTAWPSKDELKAHLEFLAEAEKRDHRKLGNELDLFSIPEQIGSGLAVFHPKGGIIRRVMEDYSRKRHEEEGYEFVYTPHATKGKLFETSGHLDWYADGMYPPMQLDEGVDYYLKPMNCPMHNLIFDARGRSYRELPLRMFEFGTVYRYEKSGVVHGLTRARGFTQDDAHIYCTREQMGEELDRTLTFVLDLLRDYGLNDFYLELSTKDPEKFVGSDEAWEEATETLRKVAEKQGLELVADPGGAAFYGPKISVQAKDAIGRTWQMSTIQLDFNLPERFDLEYTAADGTKQRPVMIHRALFGSIERFFAVLLEHYAGAFPAWLAPVQAVGIPIGDAHVEYLQDFAAEAKKKGLRVEVDASSDRMQKKIRNAQKAKVPFMIIVGDDDMSAGTVSFRYRDGSQENGVPRDEALAKLVDVVERRVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQF2</accession>
    <name>A0A2G1XQF2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2752 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00530</name>
        <name evidence="4" type="ORF">CYQ11_07540</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53452">
        <property type="protein sequence ID" value="PHQ53452"/>
        <property type="gene ID" value="BLA24_00530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12757">
        <property type="protein sequence ID" value="PPT12757"/>
        <property type="gene ID" value="CYQ11_07540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="15407" checksum="775B6A63B1A503B3" modified="2018-01-31" version="1">MRDHVRAEAVGGPPRAASTSTARRLAAPLGVAAGVGAAVAWVAAVDPGRPGHYPVCPLLSWTGLYCPGCGGLRGLHALAHGDPVAALGANALAVAAYAAFAVLWVRWLVAAVRTGGGMPVVPRARHWWLLGGILFVFTVVRNLPLGAALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X990</accession>
    <name>A0A2G1X990_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA starvation/stationary phase protection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30220</name>
        <name evidence="5" type="ORF">CYQ11_23310</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47791">
        <property type="protein sequence ID" value="PHQ47791"/>
        <property type="gene ID" value="BLA24_30220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15416">
        <property type="protein sequence ID" value="PPT15416"/>
        <property type="gene ID" value="CYQ11_23310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="156" mass="16699" checksum="FC40075703FD37F4" modified="2018-01-31" version="1">MSVVKSPLSEQDRKIVGDSLQGALVDLVDLSLVAKQVHWTVVGPRFRSVHLQLDDVVASARKHADTVAERASALGITPDGRAETVAKTSGIGAVGGGWTKDTEAVRTLVEALGAVITRMRERVQATADPDPVTQDLLIGLTGDLEKHHWMFQAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9A7</accession>
    <name>A0A2G1X9A7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_30300</name>
        <name evidence="6" type="ORF">CYQ11_23395</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47806">
        <property type="protein sequence ID" value="PHQ47806"/>
        <property type="gene ID" value="BLA24_30300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15431">
        <property type="protein sequence ID" value="PPT15431"/>
        <property type="gene ID" value="CYQ11_23395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ47806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="28256" checksum="B174D5EBAD084D3E" modified="2018-01-31" version="1">MSEVSVTKDAAPAADALVVLDKVNKHFGALHVLQDIDLTIARGEVVVVIGPSGSGKSTLCRTINRLETTDSGSISIDGKPLPQEGRELARLRADVGMVFQSFNLFAHKTVLENVTLGQVKVRRKDRKEAEKTARALLDRVGVGAQADKYPAQLSGGQQQRVAIARALAMDPKVMLFDEPTSALDPEMINEVLEVMQQLARDGMTMVVVTHEMGFARSAANRVVFMADGRIVEEARPDQFFNNPRSDRAKDFLSKILHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9J1</accession>
    <name>A0A2G1X9J1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ISAs1 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30810</name>
        <name evidence="5" type="ORF">CYQ11_23905</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47897">
        <property type="protein sequence ID" value="PHQ47897"/>
        <property type="gene ID" value="BLA24_30810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15522">
        <property type="protein sequence ID" value="PPT15522"/>
        <property type="gene ID" value="CYQ11_23905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032806">
        <property type="entry name" value="YbfD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13808">
        <property type="entry name" value="DDE_Tnp_1_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758309" evidence="1">
        <location>
            <begin position="34"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1_assoc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="98"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="39627" checksum="7F96568EEB7C27FB" modified="2018-01-31" version="1">MPDPRARRGIRHPWTALLTAAAAAVLAGATSMAAVGDWVTDAPQRVLARLGFCPDPLTGLIRPPHPTTIRLVLAAVDGDALDRAIGRFLQRRNGPPTSRPVIAVDGKTLRGSRAKDQPATALIAAMTHQGDVLAQMHLDAKSNEIPAFAPLLDGIDLTEAVITADALHTQHEHAAYLHERGAHYLAVIKRNHPTLHERVRRLPWRDIRLDHIERGRAHHRDEIRRLKTAAFAHLDYPHARQALQVVRWRRDLGSGKLTIARIHLVTSLPPGAATGEQLATWIRGHWKIENQLHHVRDRTFREDASKIRTRHLPRTMASLRNLAIGVHRQDGHTNIAAALRRTGRDYQRPLTTLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9L1</accession>
    <name>A0A2G1X9L1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30935</name>
        <name evidence="3" type="ORF">CYQ11_24035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47917">
        <property type="protein sequence ID" value="PHQ47917"/>
        <property type="gene ID" value="BLA24_30935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15542">
        <property type="protein sequence ID" value="PPT15542"/>
        <property type="gene ID" value="CYQ11_24035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1845" mass="205461" checksum="8C95885C15494892" modified="2018-01-31" version="1">MTYDSLINHGDYLSAHYLAEVLPKDLKAKDGLLARWAETEEQARRAHAAAVAEAKAEGRDPAAVPPRARTPREGLRALHGPYFASRADFARDAEALAEPDAPVPADWSKRLTELHLATLHALGYADAHEQAVAVHRAGHDHTVQALHVEPGLVAVACGWTAEPDAALDPDGAGRLLHPVALEASARLTDAKALADFLFECEEPPRYVLLLVGGVIVLADRLAWHEGRYLAADLDAALNRRDDRNGGELDTIAALFGADSLRVPEEGGTAPLASFVDKSGKHAVGVSTELREGLRLSVEWIANEVLARLRDQGVTPQQLDDPARLAKELSRESLRYLYRILFLLYAEAQPSLGILPADDPEYARGYGLQRLGDLVVRDLVGERSRRGFHLYESLDLLFRQVEEGHRQYGSEPEDLAAEAADRAATEAEREAAALLASGDISRDEYTERVREADRSRKAAARSADMGLRFEPLRSELFQKDAVRLISADRIENPSYEEGSGQPEFLDTRLRNETLHKVLRRLMLTKGKGRERGGFISYAQLGINQLGAVYEGLMSYTGFIAEEDLYEVAKGGDPSGGSWMIPASRVQDYPDEVFVQRPHEETGRPLRVVHPRGSFVYRLAGRDRQTSASYYTPKSLTEVTVELALKHRLDQDGTTTPARELLEWKICEPALGSGAFLNEAIDQVAAEYLRRREEELGRRVDPEQRQIELQKVKAYVALHNAYGVDLNATAVELAEVSLWLNSMHPGMRAPWFGLHLRRGNSLIGAGRKVYAADALPDGLWLSKKAPLAPTELPFRDGDLPEGAVHHFLLPAVGWGAVAGESEAKKLAEQQALALGKWRRGIQKAPKAPKPFEERDDEPQEKRQKRYDRWAKAASKTELVRLQRVARRAEFLWSLVAKRLELSERKVSRRIDVWGADWLTPSEEAADKQKILDDLTVPGTPYWRLKTVMDAWCALWFWPLDQVELLDGSAPEYGPGGGVLRDVAALLAGGTPAESSSAAAPVPSGPAPGDLIWQAAGLFDDPDGEQGELDGLAADDEAGLRTKARGRTAGRKAQIAEDLWRPVIPLKTFADWLDFLEAMLGTKDAEDGSFLDGLDGLPVDEALPLLEAYERSLDGVLGMDRTFNLPVRFPWLNVVEDIAGTTERDIKAEDGHGFFHWELHFAHVFRGSGGGFDLQVGNPPWVRPRWEEDTVLAELEPWFKLAEKPSVTAWRERKSEVLAEQGATPYFLGELGSNAAMAQWLGSPVTYPVLTGTQPDLYRAFMCRAWENLGTKGMAGLVHPDTHLGGTKDGKIRGAAYPRLRLRAGFVNVGNWAFEASRTAEFGVHIYGSSQRTIRFDSLSGLYGVEPLLSSLSHDGQGEVPGMKHCGAWDLRPHRSRVITVDEAMLTEWQRLEGETGIPPGQVMLLQPLTTAEQGAIAALSEVKARFGTYGPRVSQGFHEKTGKDDGFISWNTRQPASISELVIQGPHIGIATPFSKQPNMQCRGTHDWESFDLTELPGGAVPRTNYARPGSCSLKCYEETKDRWLDYSRLKNDWEPSPEQWANREEVLSEEELELSEDEQRGLLRRRMWWFRPYTQFYRLAWRKMIPFNTERSLFPALIPPGPTHIHGVLSAALGDNRLTALNAGFWASLPLDYRLRITGKANLEPGEAQKLPAADPAHPLATPLLLRTLRLNCLTNAYAPLWAELYDMTWPGYEDWAVKWPRLAPLARHLKPDWEYATPLRTEYERRAALVEIDALVAAWLGMSADELVAIHKARYAILADRESQMWFDAKGRQLAQDPYAHGHGQTKEHYEHFLAYDKGKRPNPPEGYTAPFYKANREKEMRAAHAVFEKRLQDAIDKGEWDPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9P5</accession>
    <name>A0A2G1X9P5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31245</name>
        <name evidence="4" type="ORF">CYQ11_24285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47943">
        <property type="protein sequence ID" value="PHQ47943"/>
        <property type="gene ID" value="BLA24_31245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15567">
        <property type="protein sequence ID" value="PPT15567"/>
        <property type="gene ID" value="CYQ11_24285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="402" mass="43738" checksum="951F3C01DAD54D60" modified="2018-01-31" version="1">MHDVKAVVFPACAALCALAFLYKLRDVRHQRDDPALRALLVAFSCKGVSFTLSTPLVARKVDDALGVRDLGALGIHLFGGVASSAAFLTAIVYWVYPREEARRRALARLGAAAVVAVVMFSLWIAAKSGVQQRSAHYLLQNAHRPVVAAYLLLYVSAFGSGMIEIIRLCGRYGRVAGRQWLRRGLHTTAIGASACLVYCLNRALSVVTVQLGLDPLEWELLTPVANGTGIFFLVAGLTMPSWGPRVSDARRLARNFVTYQRLHPLWHALSTAIPDIALNPQSDNRLTHLLPGDINYRLYRRVIEIQDGLLALRPYTDPDVVAAAERSGHEAGLSGDRLHARVQATSLAAALRAKRDRQQPGGEPVPLRPDATGGGGYADEVAWLLKVARAYTALPSAERTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Y0</accession>
    <name>A0A2G1X9Y0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LysE family translocator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_31720</name>
        <name evidence="7" type="ORF">CYQ11_24775</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48023">
        <property type="protein sequence ID" value="PHQ48023"/>
        <property type="gene ID" value="BLA24_31720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15649">
        <property type="protein sequence ID" value="PPT15649"/>
        <property type="gene ID" value="CYQ11_24775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="22195" checksum="EC8B6A17DBE21A8F" modified="2018-01-31" version="1">MTTAMLGFALFSLLVTMAPGPDTLLVLRNCLRGGRRTGSATALGAAVGSLAWGVAAAFGLAAALQRWDAAFTVVRLAGAAYLVFLGAQALWAQRRAARAAAGPQEAYGAQEPAGRAPGLGEAFRQGLLSCLLNPKVGVFFVAVVPQFLPEGGSPLGATLLFGVVDAVIAAAWMLLVAVCAARMLTWLRRPRVHRNLERATGGVLVALGVGTAAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA45</accession>
    <name>A0A2G1XA45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyphosphogluconate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32165</name>
        <name evidence="3" type="ORF">CYQ11_25220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48098">
        <property type="protein sequence ID" value="PHQ48098"/>
        <property type="gene ID" value="BLA24_32165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15723">
        <property type="protein sequence ID" value="PPT15723"/>
        <property type="gene ID" value="CYQ11_25220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="21407" checksum="3140AE55B1730E38" modified="2018-01-31" version="1">MYRWEITRAVLAQRVVAVVRGDSYDRATVAAGHLLSAGITGLEISLTTPFALEAVTTLCREVGDEAVIGAGSVLDGTSARMAVDAGARFLASPAVDAAVIRTGHRYGVPVLPGVATATEVVRAMELGADALKVFPAAGRRPAWLAELRAELPQAALVPGGGISVDEAPAWIAAGAVACAVGGELAEGDRDSVAKRVADLLGRLAEAAGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA74</accession>
    <name>A0A2G1XA74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32370</name>
        <name evidence="3" type="ORF">CYQ11_25420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48128">
        <property type="protein sequence ID" value="PHQ48128"/>
        <property type="gene ID" value="BLA24_32370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15754">
        <property type="protein sequence ID" value="PPT15754"/>
        <property type="gene ID" value="CYQ11_25420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="214" mass="23094" checksum="ECE71D1324869310" modified="2018-01-31" version="1">MKLTKHSHACVRLEKDGRTLVIDPGAFSERDAAVGADAVLVTHEHLDHFDEDRLRAALEANPAAELWTLRSVAEKVSAAFPGRVHTVGEGDAFTAAGFDVQVHGQMHAVIHPDIPRITNVGYLVDGSVFHPGDALTLPGQPVETLMVPVMAPWNKVSEIIDYVREIKPRRAIDIHDGLLADLARPVYDRMLGPDGPGVAGADHSRMAAGESVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA83</accession>
    <name>A0A2G1XA83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32440</name>
        <name evidence="2" type="ORF">CYQ11_25490</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48140">
        <property type="protein sequence ID" value="PHQ48140"/>
        <property type="gene ID" value="BLA24_32440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15766">
        <property type="protein sequence ID" value="PPT15766"/>
        <property type="gene ID" value="CYQ11_25490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17443" checksum="F29C812BF3EBB0E2" modified="2018-01-31" version="1">MTHRHQRAAAAKLVARLPELPRPWDVEALCRALAEMRGRPLTLHPMDLPAMPFGLWFDDGTGDRIVYRSSATGYYRDHIVLHEICHMLAGHGALPEHGAIQADPAGGAQEPVSGKPCSNAEEELAETFSTMVLKTAGQLRPKKVSAVERRAEELLGAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA89</accession>
    <name>A0A2G1XA89_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate--protein ligase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Lipoate--protein ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32480</name>
        <name evidence="3" type="ORF">CYQ11_25530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48146">
        <property type="protein sequence ID" value="PHQ48146"/>
        <property type="gene ID" value="BLA24_32480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15772">
        <property type="protein sequence ID" value="PPT15772"/>
        <property type="gene ID" value="CYQ11_25530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="128"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="351" mass="38350" checksum="231A3113EC99A49F" modified="2018-01-31" version="1">MHGEYKVPGGKLVVVDLDVVDGALRDVRVAGDFFLEPDEALFDINRALEGANADLPAPELAGRIDAALPEGTVMFGLTSEAVGVAVRRALANATDWHDYDWQLIHTGPQSPALHMALDEVLTAEVAAGRRAPTLRVWEWESPAVIIGSFQSLRNEVDMESAERHGMTVVRRISGGGAMFVEPQSTITYSLYVPDSLVQGLSFADSYAYLDDWVLAALGDMGIKAWYQPLNDIATDAGKIAGAAQKRMVGENGAVLHHVTMAYDIDADKMLDVLRIGKEKLSDKGTKSAKKRVDPLRRQTGLPRAEVIDRMIASFRNRYGCSVGEVTEQELSRAQELAQTKFSSPEWTARVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAB4</accession>
    <name>A0A2G1XAB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein meaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_32540</name>
        <name evidence="11" type="ORF">CYQ11_25590</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48155">
        <property type="protein sequence ID" value="PHQ48155"/>
        <property type="gene ID" value="BLA24_32540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15781">
        <property type="protein sequence ID" value="PPT15781"/>
        <property type="gene ID" value="CYQ11_25590"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="9">
        <location>
            <begin position="531"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="670" mass="72961" checksum="DBCEF5C7708EEE6E" modified="2018-01-31" version="1">MTERQKDRPWLMRTYAGHSTAEASNELYRRNLAKGQTGLSVAFDLPTQTGYDPDHVLARGEVGRVGVPVAHLGDMRRLFQDIPLEQMNTSMTINATAMWLLAMYQVVAEEQGADVAKLQGTTQNDIVKEYLSRGTHVFPPGPSLRLTTDMITYTVAHIPKWNPINICSYHLQEAGATPVQEISYAMSTAIAVLDAVRASGQVPEEKFGDVVARISFFVNAGVRFIEEMCKMRAFGRIWEHITRERYGIDNPKQRRFRYGVQVNSLGLTEAQPENNVQRIVLEMLAVTLSKDARARAVQLPAWNEALGLPRPWDQQWSLRIQQVLAHESDLLEYDDIFAGSHVVEAKVDALVTECLAEIERIQEMGGAMAAVESGYLKSQLVSSHAERRARIEAGEEKIVGVNCYEGTEPNPLTADLDTAIMTVDPANEARVVAALHRWRDDRDETRAQEALSVLKKTAAGSENLMAATLECVRAGVTTGEWSWALRDVFGEFRAPTGVSGAPLAVTAEAGTPLAAVREKVARTAQDLGGGRLRLLVGKPGLDGHSNGAEQIAVRARDAGFEVVYQGIRLTPEQIVSAAVAEDVHCVGLSILSGSHAELVPDVLTRLRGTGADDVPVIVGGIIPSADAAALRAAGVAAVFTPKDFGITEIIGRIVDEIRKANRLDPLEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD4</accession>
    <name>A0A2G1XAD4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32740</name>
        <name evidence="3" type="ORF">CYQ11_25790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48190">
        <property type="protein sequence ID" value="PHQ48190"/>
        <property type="gene ID" value="BLA24_32740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15816">
        <property type="protein sequence ID" value="PPT15816"/>
        <property type="gene ID" value="CYQ11_25790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="56"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="16208" checksum="2CC87AD5008CB8C4" modified="2018-01-31" version="1">MLAAMGEHGVDTLDALLEKLRIRYGRQEWGSQSWEGCRRRVHERRPPIPQANPDADPDGLLYGRSVCITGTLTSMTRAEAQALLAEAGAQATGSVSHRTDILVVGVADPSRFAPGMALSSKHRRAQELLDAGHDIEVITEADLREQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAM9</accession>
    <name>A0A2G1XAM9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_33280</name>
        <name evidence="2" type="ORF">CYQ11_26330</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48280">
        <property type="protein sequence ID" value="PHQ48280"/>
        <property type="gene ID" value="BLA24_33280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15910">
        <property type="protein sequence ID" value="PPT15910"/>
        <property type="gene ID" value="CYQ11_26330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="173" mass="17709" checksum="8F9D27F4FF703789" modified="2018-01-31" version="1">MGFAVAEDVSVARRVPERPRHGDLAWSPRVLSGYRTGRRAGDERLTPDSVVRVALRAQRTAGPSGGLVPAVLRAPRGTGFVGFAQGPSALITPSVARGPRRAGLGRYRTLRGAGPVVGPAPGSSVRAASLPRGEAGFLNGSALMPGAHPVLARSSVDMPRAHRGNGGEVPGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAT1</accession>
    <name>A0A2G1XAT1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Insulinase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30570</name>
        <name evidence="5" type="ORF">CYQ11_23665</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48330">
        <property type="protein sequence ID" value="PHQ48330"/>
        <property type="gene ID" value="BLA24_30570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16754">
        <property type="protein sequence ID" value="PPT16754"/>
        <property type="gene ID" value="CYQ11_23665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="185"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="455" mass="48017" checksum="9DF6A8F03C8868BF" modified="2018-01-31" version="1">MEFHPQPQPGLPSPWDFPAPERGQLPNGLTVLRCHRPGQQVVAVEVVLDAPLDAEPEGLDGVATIMARAFSEGTDKLSAEDFTAELERCGATLDAHADHPGVRVSLEVPASRLPKALGLLADALRAPAFPDNEVERLVLNRLDEIPHELANPARRAAMALAAELFPAGTRMSRPRQGSQETVERIDAAAVRAFYEAHVRPAAATVVVVGDFTGVDLDHALAESLGAWTGGPAEPRPMPAISTEDAGRVVIVDRPGAVQTQLLLGRVGTDRHDRAWPAQVLGTYCLGGTLTSRLDRVLREEKGYTYGVRAFCQALRSAPDGTGLGMVAVSGSVDTPNTGPALEDLWGVLRTLAAEGLTEAERDVAVQNLVGVAPLKYETAAAVAGTFADQVEQYLPDDYQAGLYERLAETGTVEATAAVVNAFPADRLVTVLVGDAAEIAEPVKALGIGPVTVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB65</accession>
    <name>A0A2G1XB65_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29420</name>
        <name evidence="3" type="ORF">CYQ11_06055</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48484">
        <property type="protein sequence ID" value="PHQ48484"/>
        <property type="gene ID" value="BLA24_29420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12519">
        <property type="protein sequence ID" value="PPT12519"/>
        <property type="gene ID" value="CYQ11_06055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="327" mass="35581" checksum="76F3ACBB30C71733" modified="2018-01-31" version="1">MTPPPPLGRPRNKDGPAFDPALDDTALAAARDALARGRWADARQLLARTGDDWDRRGHRLVALGRPPTAAAWAREWQLAEPDSPDAAALLAFATVFRALGGKDAPDAARALCLAAGRMAPRDPTPWLGALVLARRTGTDDERVRAFDQVRARHRDHHHAHHLMAACLAEHQDGDRDDPLHEVYDFAAWAAEQAPADSPLAVLPVVAHAERYRVLARAGLEPGDPARSGHWRTRRARQVMKSAFDWWLEWDVDEDAADAPDTAGSSHPRRKVDLNFLAHAKLHEGRTAEAAALLTRIGPHATPAPWSYPGQDPGAAFRAARRAALGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB68</accession>
    <name>A0A2G1XB68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29270</name>
        <name evidence="4" type="ORF">CYQ11_06205</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48460">
        <property type="protein sequence ID" value="PHQ48460"/>
        <property type="gene ID" value="BLA24_29270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12545">
        <property type="protein sequence ID" value="PPT12545"/>
        <property type="gene ID" value="CYQ11_06205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="878"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="911"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1203" mass="128812" checksum="2477294EA57A6BCD" modified="2018-01-31" version="1">MSDTSTRTEERAVEPAARRLRLPGRGGGSPLFRNAFALMLNTGISAVLGVGFWLVAARYYTEESVGQGSAAIAAMKLLAGLTAVTLTGALARFIPVAGRTTGRLVLGTYAGSSALVAVAAGVFLLTLDLWGPSYAFLHGVLPGLGFAAAVVAWSLLTLQDGVLTGLRSALWVPVGNTVFSAVKLALLVGLAATLPVSGVFVSWVVSIAVSVVPLGWLVFRRLVPAHVRATEESAQPASYREMGRFLAGDCTGSLFSLAVVYLVPVIVAAQVSSADNAYFYITSTIGGTVNLLAINMGASLTVEGSHDPARLAENCRAALRRMAKIMVPVCVLLFVLAPHVLRVFGQGYADAATPLLRWFAVGAALRVVMEVYFAVLRAQSRTAGLAYLQGLLCFLVLGLTLLLLPRMGLTGAGVAEICSLTVIVSIAAVKLRAVLKAARVPASPAAPVTTETPPDGDLADLAVHGDRRDDADGERETTRLGTRRALRKVLDADTVPLGVRVDIDHLERRPDVRPAGEAAERAPAPPGPDEAAVSPARPRWRTPEAAVWLLLAAALALYWLPLKAVGEVSLDGMGGLGLVSVLPVATLVGAALLVLAFASALWLDRPRTWLLLTILLLTVVSLHAVPALLEDRPRFATAWQHLGFLDYIDRTGTAVPDLDARWSWPGFFALVAFAARACGVHDLTEVLRWWPTAVQLLCLAPLALLLRAVRAGWRAKWTALWLFALCGWVGQDYFSPQSLNYLFYLLFVAVLLVWFRWPGQLRGKLLPGEREVARAGRGELTALLALLLALFTASVTSHQLTPFVMLGVLTALVLVRRSALTGLPLLCGVILAVWVGFLAEPYWSGHFDELFGGLGSLGGNVSSSVSGRIEGGSQTHKLVLSIRVALACGVLACAALGWWRRRRAKVGDRSLLVLTAVPFLAFGMQSYGGEVALRVFLFALPGACVLAALALFPKTTTGPGRTYRGPVAVLLTGVVLVFGFLVARWGNESFERVRAGEAAAMDYVYRHDEPTVRLLWMSSDTVNDVTPSMPWGARDMERVLYEPTLAPRDPAQVPDLVQALRRAGPRAYLMVSRGQSVYLEMSAGYAPDWEQRTRRALDGRPELRRVLVNADAALYELKDKPAGAAPEPRPGPAGPRVTWNPVSVVGGLAAVALLVLLTVRELVRVGAGPGVRQLRWVRGAFWFAVPLLVVVLGSLVWRMATMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBU8</accession>
    <name>A0A2G1XBU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28660</name>
        <name evidence="3" type="ORF">CYQ11_06805</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48681">
        <property type="protein sequence ID" value="PHQ48681"/>
        <property type="gene ID" value="BLA24_28660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12638">
        <property type="protein sequence ID" value="PPT12638"/>
        <property type="gene ID" value="CYQ11_06805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="139" mass="14682" checksum="0960967823D04FDB" modified="2018-01-31" version="1">MTETVSQTSQPPAERGRTTIADGVVEKIAGLAARDVVGVHALGSGLARTFGAVRDRVPGGGRSVTRGVKAEVGEVQTALDLEIVVDYGVAITDVAHSVRENVILAVERMTGLEVVEVNIAVSDVKLPDEEEEEPEPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC16</accession>
    <name>A0A2G1XC16_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28790</name>
        <name evidence="2" type="ORF">CYQ11_06675</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48741">
        <property type="protein sequence ID" value="PHQ48741"/>
        <property type="gene ID" value="BLA24_28790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16387">
        <property type="protein sequence ID" value="PPT16387"/>
        <property type="gene ID" value="CYQ11_06675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="97" mass="10648" checksum="8CC3AF4A578ED40C" modified="2018-01-31" version="1">MLLLTAAAVLTAAATPRAPDPRREAECHTRVRGSHVTASCYNGNATTDRVQLHVTCARWWDPAMDTAVVDVGPARRADLAQRCWLEVRDAWVTHDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC51</accession>
    <name>A0A2G1XC51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase carboxyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27535</name>
        <name evidence="4" type="ORF">CYQ11_18110</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48823">
        <property type="protein sequence ID" value="PHQ48823"/>
        <property type="gene ID" value="BLA24_27535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14531">
        <property type="protein sequence ID" value="PPT14531"/>
        <property type="gene ID" value="CYQ11_18110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="276"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="532" mass="56219" checksum="739804503DFC4E10" modified="2018-01-31" version="1">MTVLASALDTAGPGYAANRAAMLDKLAAIEAEHAKAVAGGGERYTARHRARGKLTARERVELLLDPDTPFLELSPLAAWGSEYPVGASLVTGVGVVEGVECVVTANDPTVRGGASNPWTLKKALRANEIAFANRLPVVSLVESGGADLPGQKEVFIPGGGLFRDLTRLSAAGIPTVAVVFGNSTAGGAYVPGMSDHVVMVKERAKVFLGGPPLVKMATGEESDDESLGGAAMHARVSGLADHFAVDEPDALRQARRVVARLNWRKAHPAPGPFADPLYDPEELLGVVPGDLKVPFDPREVLARVVDGSDFDEFKPLYGPSLVTGWARLHGYPVGVLANARGVLFSAESQKAAQFIQLANQRDIPLLFLHHTTGYMVGRDYEQGGIVKHGAMMINAVANSRVPHLSVLMGASYGAGHYGMCGRAFDPRFLFAWPSAKSAVMGPQQLAGVLSIVARASAAAKGRPYDEEADAGLRAMVEQQIEAESLPAFLSGRLYDDGVIDPRDTRTVLGMCLSAVHTAPVEGTRGGFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC73</accession>
    <name>A0A2G1XC73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Succinate-semialdehyde dehydrogenase (NADP(+))</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gabD2</name>
        <name evidence="6" type="ORF">BLA24_27370</name>
        <name evidence="7" type="ORF">CYQ11_18275</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48795">
        <property type="protein sequence ID" value="PHQ48795"/>
        <property type="gene ID" value="BLA24_27370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14555">
        <property type="protein sequence ID" value="PPT14555"/>
        <property type="gene ID" value="CYQ11_18275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="48"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="540" mass="57141" checksum="271EB7F05B5310E0" modified="2018-01-31" version="1">MTDPQDTGTVTDGNSRNPAVPAGARGAADVVTPGLVDRLTRCVVSTGGTTTSRTPLTGDVLAELPVSTPEDVAGAFARARQAQRAWAATPVRRRAAVLLRFHDLVLARQSEVLDLIQLETGKARLHAHEEVQAVAVAARHYGHAAPALLRPKGHTGVLPLLTKATELRRPRGVVGQIAPWNYPFELSVGDALPAFAAGNAVVMKPDTQTALTALWARRLLVEAGLPEGVWQVVLGDGPVVGPAVVAHADYVSFTGSTRTGREVARGAAARLVGCSLELGGKNAMLVLRDADVEKAAAGAVRACFSSAGQLCVSIERLYVHSSLADDFLRRFTARTKAMRLGTALAYGADMGSLISARQLETVTRHVEEAVAKGATVLAGGRPRPDVGPFFHEPTILDGVEPPMAVCAEETFGPVVSVYRFDDEDEAVRRANATPYGLNASVWTTDGRRGRALAARLDAGTVNVNEGYAAAYGSARAPMGGMGDSGLGRRHGSEGLLKYTEAQTVAHQRIMPLAPAFGLDDEQYARVMTRGLRLLKAVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCN7</accession>
    <name>A0A2G1XCN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23245</name>
        <name evidence="4" type="ORF">CYQ11_22830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49017">
        <property type="protein sequence ID" value="PHQ49017"/>
        <property type="gene ID" value="BLA24_23245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15338">
        <property type="protein sequence ID" value="PPT15338"/>
        <property type="gene ID" value="CYQ11_22830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="185" mass="19754" checksum="F4F2FC5AD4AB9DBB" modified="2018-01-31" version="1">MAEHRTMQRAALLDAARSLLSEGGTEALTFPALAERTGLARSSVYEYFRSRAAVVEELCAVDFPVWAAEVEAAMERAGTPEGKIEAYVRQQLALVGDRRHRAVVAISAGELDAGAREKIRAAHGGLIAMVVEALLALGHEQPRLTAMLLQGVVDAAVRRIELGAAEEPDRITEAAVGMALRGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCR2</accession>
    <name>A0A2G1XCR2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ORF">BLA24_23305</name>
        <name evidence="18" type="ORF">CYQ11_22770</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49026">
        <property type="protein sequence ID" value="PHQ49026"/>
        <property type="gene ID" value="BLA24_23305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15328">
        <property type="protein sequence ID" value="PPT15328"/>
        <property type="gene ID" value="CYQ11_22770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ49026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT15328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="29818" checksum="EF406CD512F5F243" modified="2018-01-31" version="1">MRLDVVTIFPEYLEPLNVSLVGKARARGQLDVRVHDLREWTHDKHNTVDDTPYGGGPGMVMKPEPWGEALDSIIESGEGQPTIVVPTPSGKPFTQELAVELSEKPWLVFTPARYEGIDRRVIEEYAERVDVREVSIGDYVLAGGEAPVLVMVEAVARLLPGVLGNAESHRDDSFAPGAMADLLEGPVYTKPPEWRGRGIPEVLLSGHHGKIARWRRDEAFRRTAVNRPDLLERADPGAFDKKDREMLSILGWAPGADGRFGRLGQDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD69</accession>
    <name>A0A2G1XD69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24315</name>
        <name evidence="2" type="ORF">CYQ11_21755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49194">
        <property type="protein sequence ID" value="PHQ49194"/>
        <property type="gene ID" value="BLA24_24315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15156">
        <property type="protein sequence ID" value="PPT15156"/>
        <property type="gene ID" value="CYQ11_21755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="14481" checksum="61E36FC409509DDE" modified="2018-01-31" version="1">MSLDVSPALLEQAERGEVDEAEFVDCVRTSLPYAWEMISSLVDRLQADGGEFADNRTPPPDEQARGQLLRALASDAIRGALQRHFGVRLAFQNCHRVAVFPLDASVDQRLARFTSIRGQLLNQSPELRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD78</accession>
    <name>A0A2G1XD78_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24085</name>
        <name evidence="4" type="ORF">CYQ11_21985</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49151">
        <property type="protein sequence ID" value="PHQ49151"/>
        <property type="gene ID" value="BLA24_24085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15198">
        <property type="protein sequence ID" value="PPT15198"/>
        <property type="gene ID" value="CYQ11_21985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="20970" checksum="DCF639C931E98264" modified="2018-01-31" version="1">MAGRRTDTRKRAQRVALQLFSEHGYDGTSLRMIAEQLNITKAALYYHYKSKEEILAAVLADFSAAVAELTDWGKQQPAGPETRRELLRRYAELTAGGITAAARFVQDNEPALRNQPLAAEVQQHVMTLFELLAGPGALSGDGDPAASLRVRLAITALHLAGDEADRAENGGPELIDAALGIACDLIDPPSPRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDA5</accession>
    <name>A0A2G1XDA5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpD</name>
        <name evidence="13" type="ORF">BLA24_24400</name>
        <name evidence="14" type="ORF">CYQ11_21670</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49210">
        <property type="protein sequence ID" value="PHQ49210"/>
        <property type="gene ID" value="BLA24_24400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15139">
        <property type="protein sequence ID" value="PPT15139"/>
        <property type="gene ID" value="CYQ11_21670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="158"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ49210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="480" mass="52093" checksum="1E122AA09E48B529" modified="2018-01-31" version="1">MTTTVETAAATGRVARVIGPVVDVEFPVDAMPEIYNALHVEVDDPAEEGGRKTLTLEVAQHLGEGLVRAISMQPTDGLVRQAAVTNTGTGITVPVGDVTKGKVFNTLGQVLNDDPSVTADAERWAIHRKAPAFDQLESKTEMFETGLKVVDLLTPYVKGGKIGLFGGAGVGKTVLIQEMIMRVAKLHEGVSVFAGVGERTREGNDLMVEMEEAGVLDKTALVFGQMDEPPGTRLRVALAGLTMAEYFRDVQKQDVLFFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGLLQERITSTRGHSITSMQAIYVPADDLTDPAPATTFAHLDATTVLSRPISEKGIYPAVDPLDSTSRILDPRYIAQEHYECASRVKGILQKYKDLQDIIAILGIDELGEEDKLVVHRARRVERFLSQNTHAAKQFTGVDGSDVPLDESIAAFNAICDGEFDHFPEQAFFMCGGLEDLKKNAKELGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC3</accession>
    <name>A0A2G1XDC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24555</name>
        <name evidence="5" type="ORF">CYQ11_21515</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49237">
        <property type="protein sequence ID" value="PHQ49237"/>
        <property type="gene ID" value="BLA24_24555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15111">
        <property type="protein sequence ID" value="PPT15111"/>
        <property type="gene ID" value="CYQ11_21515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="239" mass="25219" checksum="C6CA4896FEABEFF1" modified="2018-01-31" version="1">MDSADSDEKDVVTGTDGAVAAGAADAVADAVADAGDPAPDEQARGWQLDLSRAPNATKIVIAGGFGVGKTTFVGSVSEITPLRTEAVMTTAAEDVDDLTAVPDKATTTVAMDFGRITLDADLVLYLFGTPGQKRFWFMWDDLVRGAIGAVVLVDTRRLADCFPALDYFESGGLPYVVAVNHFDGATRHAPEVVREALALPADVPVVTMDARRRITVVETLLTLVGRALAVTDTGPQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDL5</accession>
    <name>A0A2G1XDL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis protein MoeE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25040</name>
        <name evidence="2" type="ORF">CYQ11_21030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49322">
        <property type="protein sequence ID" value="PHQ49322"/>
        <property type="gene ID" value="BLA24_25040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16699">
        <property type="protein sequence ID" value="PPT16699"/>
        <property type="gene ID" value="CYQ11_21030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="154" mass="16144" checksum="874807F9BAD25A75" modified="2018-01-31" version="1">MGAMSHPHHPGELAAPDPVRLLAVRDTPLSLDEVFAAVGDDAAGGTALFVGTVRDHDGGADVAGLGYSAHPSAEAELRRVAQKVVDDFPVRALAAVHRVGELAVGDLAVVVAVSCPHRAEAFAACRRLIDDLKSEVPIWKHQNFADGTEEWVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE97</accession>
    <name>A0A2G1XE97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26390</name>
        <name evidence="5" type="ORF">CYQ11_19250</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49557">
        <property type="protein sequence ID" value="PHQ49557"/>
        <property type="gene ID" value="BLA24_26390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14723">
        <property type="protein sequence ID" value="PPT14723"/>
        <property type="gene ID" value="CYQ11_19250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="210" mass="23515" checksum="CD27E688CC224473" modified="2018-01-31" version="1">MLTMASAQTSPTAQPGSRLGLRERKKIQTRQAIRRAAYRLFAEHGYDSTSVDRIAEAADVSPSTVFRYFPTKEDIVLTDEYDPVLEAAIRARPAQESPVEAIRQGVLDSMRQIIEHDLVELRERTRLVRDVPALRGRSAEGMGESARMLCKVLAERTGRDADDLELRIVITAVLASMQEAMMYWVEQGQTEDVVALIDRTLDVLGRGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC6</accession>
    <name>A0A2G1XEC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxypeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26355</name>
        <name evidence="5" type="ORF">CYQ11_19285</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49551">
        <property type="protein sequence ID" value="PHQ49551"/>
        <property type="gene ID" value="BLA24_26355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14728">
        <property type="protein sequence ID" value="PPT14728"/>
        <property type="gene ID" value="CYQ11_19285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304598" evidence="1">
        <location>
            <begin position="30"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="443" mass="47858" checksum="89E7D2DC2F6ECFA8" modified="2018-01-31" version="1">MRPSLPHPRKNIGRWATAALAATLSLAFAAPASSGGEEHSARSYEVTGPRTAAQRTAVAATGASVDAVRGGSVVITASRDQADRVRGMGYTVRALPGPPDRDDGRTATPFDFPPADANYHNYKEAMAEIDADVAAHPSLMSKQVIGKSHEGRDIIAVKITNSAKGAAPGGAAKPEVLFTHHQHAREHLTVEMALYLLKEFGSQYGKDARVTKMLDSRVIWVVPDVNPDGGEYDVATGTYRGWRKNRQPNSGSSSRGTDLNRNWNFKWGCCGGSSGSTGSETYRGAAPESAPEVKVVADFVRSRVVDGRQQIKAAIDFHTYSELVLWPFGWTYDDTAPGMTRDDRDTFAAIGKSMAASNGYTPEQSSDLYITDGSIDDWLWGTQKVFAYTFEMYPDASGSGGGFYPPDEVIARETARNREAVLQLLEAADCPYRAIGKEGQYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEJ5</accession>
    <name>A0A2G1XEJ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26625</name>
        <name evidence="2" type="ORF">CYQ11_19010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49599">
        <property type="protein sequence ID" value="PHQ49599"/>
        <property type="gene ID" value="BLA24_26625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14681">
        <property type="protein sequence ID" value="PPT14681"/>
        <property type="gene ID" value="CYQ11_19010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23311" checksum="762DB454C83AAE97" modified="2018-01-31" version="1">MRTNASHWCPVTSLLPSARVILLTGPSGSGKSSLAARTGLPVLNLDDFYKEGDDPSLPLLTDGGTDWDSPRSWDADAAVAAIDSLCRTARTTVPVYDISTSSRVGESALDIGRTPLFIAEGIFAADIIDRCRDLGHLADALCLRGRPSTTFRRRLLRDLREARKPVPTLVRRGLRLMRSERAIVARQTALGAFACGGQTAMGRIAAAAAGHRETVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEK4</accession>
    <name>A0A2G1XEK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26835</name>
        <name evidence="3" type="ORF">CYQ11_18800</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49635">
        <property type="protein sequence ID" value="PHQ49635"/>
        <property type="gene ID" value="BLA24_26835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14644">
        <property type="protein sequence ID" value="PPT14644"/>
        <property type="gene ID" value="CYQ11_18800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="496" mass="51481" checksum="5CFD8E572848E311" modified="2018-01-31" version="1">MTETTGTAGTTGRAGTTGALGAVVTGGGGLTAQVRALAEGTVSSRALTEETLRRIAATQPTLNAFRVVRAEAALQEAEEADRRLAAGESGPLLGVPVAVKDDMDVAGEPTAFGCAGAFPPKPADSEAVRRFRAAGAVIVGKTNTPELGQWPVTNGPAFGVTRNPWSLAHTPGGSSGGAAAAVAAGLVPAALGSDGAGSVRIPAAWTHLVGIKPQRGRISTWPEPEAFRGLTCYGPLARTVADAALLLHAASGPHERDLHRPASVDLLAAAGREPGRRLRVALSFRPAFAAVRHRLDPVVRDATVRTAELLESLGHEVVEEDPPYGPVGLTFVPRSMSGVRDWARRAPDRTLLDARTHANAQGGLLFGGGVLRVARAAEAPLRRRVGEMFGRYDVILTPTNAVPPLRADELAGLGSRETNARMIAACPYAWPWNVLGWPAVSVPSGFTAGGLPMGAQLLGPAGGEPLLISLAAQLEAVERWYERWPEQAAEGEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEP6</accession>
    <name>A0A2G1XEP6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24925</name>
        <name evidence="3" type="ORF">CYQ11_21145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49724">
        <property type="protein sequence ID" value="PHQ49724"/>
        <property type="gene ID" value="BLA24_24925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16704">
        <property type="protein sequence ID" value="PPT16704"/>
        <property type="gene ID" value="CYQ11_21145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="328" mass="35767" checksum="6B845C690554E03C" modified="2018-01-31" version="1">MRIFGKVRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADMEPWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDREAGAPDWWNVGIAATALQDWPLARRAWQAYGLKVPGEGGPAGEPAGMELGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPLPSSGRRWGEVVLHDGVPHGERVTAAGPSYPVFDEIELWAPSPVPTWVVLLEAATEADRDALERLAADAGFAAEDWSSSVRLLCRTCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHRTAGSGSLWVPERECGIAAPAGLVRGLLDGWVADSPDTREWRDLEEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XES9</accession>
    <name>A0A2G1XES9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25880</name>
        <name evidence="2" type="ORF">CYQ11_20190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49738">
        <property type="protein sequence ID" value="PHQ49738"/>
        <property type="gene ID" value="BLA24_25880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16688">
        <property type="protein sequence ID" value="PPT16688"/>
        <property type="gene ID" value="CYQ11_20190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="347" mass="37936" checksum="53A4BF9A421DFAB1" modified="2018-01-31" version="1">MNTAIGMLEQELLVPNLFTKEGVDRFKGAKNDTINVTVEGVLPFHDYEWRSGSAGSSTPGARQRVVFDEYAERTIPVTFGGNVYNGVKLTDEQADFDIHQWGKLLRPQVKAIARGLARRAVKTLVDQPYAVTVGNAEKSMRKAIIEARRVMNKFNVPEGNRYMVVGSDFETVLLSDPDLNLASNVGDGQAESALVNATLGNRYGFRFIVDQTIPADSAFAFAQSGFIFASAAPSVPQSVPFGATTSFEGLALRWLRDYDSEYFQDRSIVNCYQGFRSVKDVLVGWDPAKEKEVISTQEHFVRGIKLQLDGKSDYPEVGSELATITGVSAAKVFTPTGPAAETDPANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF25</accession>
    <name>A0A2G1XF25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19510</name>
        <name evidence="3" type="ORF">CYQ11_11285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49833">
        <property type="protein sequence ID" value="PHQ49833"/>
        <property type="gene ID" value="BLA24_19510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13392">
        <property type="protein sequence ID" value="PPT13392"/>
        <property type="gene ID" value="CYQ11_11285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="298" mass="30248" checksum="2D4D14026DCDEACB" modified="2018-01-31" version="1">MTTHAPQAAHTVTLPGSLDEAVAALSAMPTAVPVAGGTDLMAAVNRGLLRPAALVGLGRISEIRGWQYQDGAALLGAGLTHARMGRPDFAALIPALAAAARAAGPPQIRNAGTLGGNIASAQPTGDALPVLAALEASLVIAGPGGARREVPVGRLLAGLDMLRPGELIGYVRVPLLHAPQTFLKATGRTGPSRAIASVAVVLDPARRSVRCAVGAVAPMPLRPFDAERWVSSIVDWDGERTLAPDACAAFGDYVAAACIPDPVPGPGDAEPGTLPPAVLHLRRTVATLARRALGRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF80</accession>
    <name>A0A2G1XF80_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19865</name>
        <name evidence="3" type="ORF">CYQ11_10925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49894">
        <property type="protein sequence ID" value="PHQ49894"/>
        <property type="gene ID" value="BLA24_19865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13330">
        <property type="protein sequence ID" value="PPT13330"/>
        <property type="gene ID" value="CYQ11_10925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024029">
        <property type="entry name" value="Pyridox_Oxase_FMN-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04025">
        <property type="entry name" value="PPOX_FMN_DR2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="209" mass="23101" checksum="D8AD7F7D5F811A9A" modified="2018-01-31" version="1">MTTAEIVEVTSEAELRDMLGPPVPAAAQKVRRRLDEIDKQWLASSPFLLVATAAADGSCDVSPKGDPAGSTLVLDDTTVVVPERPGNRRVDGFLNVLSNPHVGLLYVIPGRGDTLRINGRARVVRDAPFFDDLVVKGHRPRLALVVDVEEVFYHCSKAFLRSALWKPETWTPDAAPSRARISKALERPEDSLEELEQYYGTSYADKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD5</accession>
    <name>A0A2G1XFD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20140</name>
        <name evidence="3" type="ORF">CYQ11_10650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49937">
        <property type="protein sequence ID" value="PHQ49937"/>
        <property type="gene ID" value="BLA24_20140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13287">
        <property type="protein sequence ID" value="PPT13287"/>
        <property type="gene ID" value="CYQ11_10650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="111" mass="12290" checksum="D5C1164784B77C00" modified="2018-01-31" version="1">MDHSDATRPLEALPEIEEAAAAELLSQLKTSLGTYQQLLDDLQAQRIDFDSFRRQAFRAGLIMRDNGALLLDLSTATWYWYDGIRLRTMGSFRDQEPPADRAAGGSAAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFI7</accession>
    <name>A0A2G1XFI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20560</name>
        <name evidence="9" type="ORF">CYQ11_10220</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50006">
        <property type="protein sequence ID" value="PHQ50006"/>
        <property type="gene ID" value="BLA24_20560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13216">
        <property type="protein sequence ID" value="PPT13216"/>
        <property type="gene ID" value="CYQ11_10220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="190"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="417" mass="44684" checksum="B080A6026B4E9760" modified="2018-01-31" version="1">MKLAVVGGGSTYTPELADGFARLRDALPVTELVLVDPVADRLELVGALARRIFARQGHPGRVSWTGDLDAAVDGADAVLLQLRVGGQAARDKDETWPLECGCVGQETTGAGGLAKALRTVPVVLGIAERIRRRNPGAWIVDFTNPVGIVTRALLTAGHRAVGLCNVAIGFQRKFARLLGVAPEEVSLDHVGLNHLTWERAVLVGGEDVLPRLLAEHGDAVAADLRMPRGLLDRLGAVPSYYLRYFYQHDEVVRELKGRPSRAAEVAEMEKRLLALYADPALDEKPELLARRGGAFYSEAAVALTSSLLTGAGDVQVVNTFNSGTFPFLPDDAVIEVPAAVDARGAHPLPARPLEPLYAGLVAHVTAYEQLALEAALKGGRDRVFEALLAHPLVGRIAQADQLTDSLIAHNREHLAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFV1</accession>
    <name>A0A2G1XFV1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21235</name>
        <name evidence="3" type="ORF">CYQ11_09550</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50113">
        <property type="protein sequence ID" value="PHQ50113"/>
        <property type="gene ID" value="BLA24_21235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13106">
        <property type="protein sequence ID" value="PPT13106"/>
        <property type="gene ID" value="CYQ11_09550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="29188" checksum="9EE41285E816C397" modified="2018-01-31" version="1">MAEPGGPDPTQARDAAALVALMRELRERSGLTYRRLQQRAAEQGMALPRSTVSAVLARDAVPRAEVLKAFVVACGDGARLGAWLEARERAAAAGPVPDDAGRAAPRAGARSRLLWLPALAAVLGLACWGFAVAAHRAGGGERSRGASPAASATPGRAGGFSLFEGRSTKGATIASVGYRYWDTGDGWYGVEYVMPYSRDDREAYDDGWGGRLLMHYEDRHGRHTAVLADHPDRGQRAGRDAVHYGVKNVWFEVCDCDGDALRGCQRLRKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFX5</accession>
    <name>A0A2G1XFX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21190</name>
        <name evidence="2" type="ORF">CYQ11_09595</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50105">
        <property type="protein sequence ID" value="PHQ50105"/>
        <property type="gene ID" value="BLA24_21190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13114">
        <property type="protein sequence ID" value="PPT13114"/>
        <property type="gene ID" value="CYQ11_09595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="91" mass="10804" checksum="860215A3C5E3CC5A" modified="2018-01-31" version="1">MTWSEAEYVEYLQSERRLYAWVMRRHGNLTLPESWAAALAAYPYEPDGTPHRGLVFHDEPWHWAMLDLHGERYTVEHPELVHPPVEYTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG14</accession>
    <name>A0A2G1XG14_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21010</name>
        <name evidence="2" type="ORF">CYQ11_09775</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50079">
        <property type="protein sequence ID" value="PHQ50079"/>
        <property type="gene ID" value="BLA24_21010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13140">
        <property type="protein sequence ID" value="PPT13140"/>
        <property type="gene ID" value="CYQ11_09775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23265" checksum="64321DA2C602004E" modified="2018-01-31" version="1">MNGSGGGRGRRIVLWRHGQTAWNIERRFQGTTDIELTGTGVAQARRAARLLAALRPDAIVASDLKRARATAAELASVTGLEVAAHAELRETYAGVWQGLTHEEIIERHGAEYAAWKRGEPVRRGGGELETEVADRAAPVVLSHAEKLPDGGTLVVVSHGGTIRTTIGRLLGLEPYSWEALGGLTNCCWSVLGEGARGWRLLEHNAGTLPEPVLGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG99</accession>
    <name>A0A2G1XG99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22200</name>
        <name evidence="2" type="ORF">CYQ11_08585</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50268">
        <property type="protein sequence ID" value="PHQ50268"/>
        <property type="gene ID" value="BLA24_22200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12946">
        <property type="protein sequence ID" value="PPT12946"/>
        <property type="gene ID" value="CYQ11_08585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="335" mass="35101" checksum="040BC03B3D49C3A2" modified="2018-01-31" version="1">MFPAAALTAAALLTATGCVTVHGERAVVPAVTRAEAAKALGRFTDGYTEAYRRLDPALVDRVETGALAEIGRADLAAQRAATPGGNPGYPALKLDDARFTVPAMAGWPKFFLADTRSNRDRNRWLVVFTRAGAGKPWKAAYLSLLGEGKVPAFALDGDGHAEAVPAAGVTGTASGAKGGAKGGASKPAPVLAPGAVSGRYTDYLRTGDGNVFAPGGSTTLLREERARLARTPNFWTDYIDSPEKEPDFPAFGLRTADGGALVFFTAHHREKRTMAEGVRPTVTDPRTKALLSGDLRHAVTYTRVSESAVAVPPRTAGGQVVFLNRIESLTAAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGA2</accession>
    <name>A0A2G1XGA2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lantipeptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21965</name>
        <name evidence="4" type="ORF">CYQ11_08820</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50235">
        <property type="protein sequence ID" value="PHQ50235"/>
        <property type="gene ID" value="BLA24_21965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12980">
        <property type="protein sequence ID" value="PPT12980"/>
        <property type="gene ID" value="CYQ11_08820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="238"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="889" mass="94396" checksum="1677E2E1A1B4F18F" modified="2018-01-31" version="1">MEKRYEVYCLADRHFYEIPDRLSAPAGTGAGTALFETARRPVPDGWKSTRSGDWLQLTPVDATGAPRPGQPAQGWKIHVSATAESADKTAAAVWDYCVPRGIPFKFVPAPHLLHLRNSKYAARDASGKFVTVYPADEDQLHTVLTELHETVGGAPGPYVLTDLRWHEGPLYVRYGAFARRYCTDAHGALVPAVEDPDGTLVPDLRNPAFQTPAWVRLPAFLEPHLAARNATTVGELPYSIEKALHFSNGGGVYRGTDTRDGSAVVLKEGRPHAGLAADGADAIARLERERDALEKLAGLGVAPGFRDWFAVGDHRFLVMDFVEGRPLNSFFAERHPLLAPDADPGAVADYTAWALRIHRAVEDAVERVHARGVVFNDLHMFNIMVAPDERSVTLIDFEAAAPASESGRQVVAHPGFVAPPDRTGTDVDRYALACLRLALFLPVTTLLAVDRSKAAHLAGVIAERFPVPREFLDEAVTEITRDTGTSGRPARAAGGTAARGTPPAGGGAAALPEPGDWPAARDSMVRAILASATPDRDDRLFPGDIAQFSDGGGLGLAHGAAGVLHALAETGAERYEQGEQWLLDHTRSAPPGTPLGLYDGLAGVAHVLHGLGHVERAMDLTGALLAEKWQRLSSGLRGGLAGVGLALDHLAEATGDLSLRDHAVQAAQVLADRLAADQAAPSGRRRAGLMHGATGPALLFLRLHERSGAPALLDLAGAALRADLAQCVRTPIGSLDVNEGWRTMPYLGDGSVGIGAVLDDYLAHRADEDLQEARSGILLAARSGFYAQPGLFQGRAGMIWHLARTTAPDATAGHLAAQISALSWYAMPYEGELAFPGHQMMRLSMDLATGTAGCLLALGAALGGDQPARLPFLPPLGAPQSRLRLAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGK6</accession>
    <name>A0A2G1XGK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19805</name>
        <name evidence="4" type="ORF">CYQ11_10985</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50364">
        <property type="protein sequence ID" value="PHQ50364"/>
        <property type="gene ID" value="BLA24_19805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16487">
        <property type="protein sequence ID" value="PPT16487"/>
        <property type="gene ID" value="CYQ11_10985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045635">
        <property type="entry name" value="DUF6412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19950">
        <property type="entry name" value="DUF6412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305522" evidence="2">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="97" mass="10146" checksum="0807DBFD8B680990" modified="2018-01-31" version="1">MSVLLYVLAELFLAQSTLSGLMSAVAFAAATSVVTAAALLLSAVAAARTGSGPLTPTRIRTAIRDRELRTAFLAQRDPDAQGRRRPRAPGRPLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGQ1</accession>
    <name>A0A2G1XGQ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22075</name>
        <name evidence="4" type="ORF">CYQ11_08710</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50424">
        <property type="protein sequence ID" value="PHQ50424"/>
        <property type="gene ID" value="BLA24_22075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16432">
        <property type="protein sequence ID" value="PPT16432"/>
        <property type="gene ID" value="CYQ11_08710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="279" mass="31033" checksum="74930A77509C99CE" modified="2018-01-31" version="1">MGPAHPRLAYGHRPLDRPRGVVRPQPLTRSPQINAAPADQIRLLDLQALDVRLTQLAHKRKSLPEHAEIVTLEGDLTQHRDLLVAAQTEESDCAREQAKAEQDVDQVRQRAARDQQRLDSGAGMSPKDLENLQREVASLAKRQGDLEDVVLEVMERRETAQERVKELTSRVESVQGKVNDAVARRDAATEVLDTEAATVTKEREIVAGSIPADLLKLYDKLRAQSGGVGAARLYQRRCEGCQLELNITELNEVRSAAPDTVVRCENCRRILVRTPESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGU2</accession>
    <name>A0A2G1XGU2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">folE</name>
        <name evidence="7" type="ORF">BLA24_16575</name>
        <name evidence="8" type="ORF">CYQ11_16710</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50460">
        <property type="protein sequence ID" value="PHQ50460"/>
        <property type="gene ID" value="BLA24_16575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14285">
        <property type="protein sequence ID" value="PPT14285"/>
        <property type="gene ID" value="CYQ11_16710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="22405" checksum="A5C1CC914DB461BE" modified="2018-01-31" version="1">MTDPVTLDAERSIGVFDEKRAENAVRELLIAVGEDPDREGLRETPARVARAYREIFAGLWQEPEDVLTTTFDLGHDEMVLVRDIEVYSTCEHHLVPFHGVAHVGYIPATTGKITGLSKLARLVDVFARRPQVQERLTTQIADSLMEILEPRGVIVVVECEHMCMSMRGIRKPGAKTLTSAVRGQLRDPASRAEAMSLIMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGZ7</accession>
    <name>A0A2G1XGZ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21430</name>
        <name evidence="3" type="ORF">CYQ11_09355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50409">
        <property type="protein sequence ID" value="PHQ50409"/>
        <property type="gene ID" value="BLA24_21430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16446">
        <property type="protein sequence ID" value="PPT16446"/>
        <property type="gene ID" value="CYQ11_09355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="246"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="335" mass="36289" checksum="05DE2E2FD3A8DF33" modified="2018-01-31" version="1">MLRVHFTGLDLARLRLAGDPDVLWETVLSLHRLRDKQGESIFGDWRSETRPRLNGETRLLAPLVPPRGYFPDFLTPAEGLLGLESGMEALRATPADRVHRELSRLSTVRTLPAWIRSLAEGDVRAFGKLIGALHAYHEAAIAPYWSHIQAQIEADRAVRGRALLDGGADALLSSLPPTMRWRAPVLEVDYPVDRDVHLDGRGLVLLPSFFCRRTPVTLQNPELTPVLVYPARTMSESAPVVPAAPRSLGKLVGHTRSAVLGSIGGGCTTSELARRVGVSAASASQHAGVLREAGLVLTLRNGSAVMHTLTPLGAALLRGGHRNPQSRARARSATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH10</accession>
    <name>A0A2G1XH10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50517">
        <property type="protein sequence ID" value="PHQ50517"/>
        <property type="gene ID" value="BLA24_16965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="178" mass="19977" checksum="68A9FD1138DA7C1D" modified="2018-01-31" version="1">MKEETRLRVEAAIAELGYVRGRGVPGQHAAHWRRSGFATWLFQPAATGWYPKKAPQVARPVPLLTDPWPGVPARGRNAASRAEMCWVPIAQGLTPHGLRHTNKKIMRDLRTPPKLMDERLGHLDGSVQARYDHITPGMRRRLMEGLTEVWEAALATRRAMCPTSPVRVLDELLRAPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH64</accession>
    <name>A0A2G1XH64_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_17285</name>
        <name evidence="5" type="ORF">CYQ11_15990</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50567">
        <property type="protein sequence ID" value="PHQ50567"/>
        <property type="gene ID" value="BLA24_17285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14179">
        <property type="protein sequence ID" value="PPT14179"/>
        <property type="gene ID" value="CYQ11_15990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="13062" checksum="1566663FD1E3C941" modified="2018-01-31" version="1">MGVYELAFTMRRRVVEGAVVVELLGEIDILAEQVLGPRLEDVAGRRRGDLVVDLRGVTFLDASGVRLLLRARRRALRCGARLRVVRGGPMISKVIRIAGVEPAFTWLDAFPPSAVGSVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHB8</accession>
    <name>A0A2G1XHB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Thiol reductant ABC exporter subunit CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_17665</name>
        <name evidence="12" type="ORF">CYQ11_15610</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50625">
        <property type="protein sequence ID" value="PHQ50625"/>
        <property type="gene ID" value="BLA24_17665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14120">
        <property type="protein sequence ID" value="PPT14120"/>
        <property type="gene ID" value="CYQ11_15610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="term" value="P:glutathione transmembrane transport"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
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        <location>
            <begin position="332"/>
            <end position="567"/>
        </location>
    </feature>
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        <location>
            <begin position="612"/>
            <end position="894"/>
        </location>
    </feature>
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            <begin position="926"/>
            <end position="1161"/>
        </location>
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            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <begin position="960"/>
            <end position="967"/>
        </location>
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    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="PHQ50625.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1187" mass="124448" checksum="DB1C75BDBE0D5701" modified="2018-01-31" version="1">MKPVDPRLLKHASATRFFLAASVVLGLAGAGLVIAQAMLIAEVVTGAFRNGLGTGDLVRPLGLLAAVALGRAAVAWLTELAAHRASAAVKSQLRTRLLAHAALLGPGVRNTGELTNLATRGVDALDGYFARYLPQLGLAAVVPVAVLARIVSADWLSALVIVLTLPLIPLFMALIGWATQSRMDRQWRLLSRLSGHFLDVVAGLPTLKVFGRAKAQAESIRQITSDYRRATLRTLRLAFLSSFALELLSTLSVALVAVGVGMRLVHGELDLRTGLLVLILAPEAYLPLRQVGAQYHAAAEGLAAADEVFAVLETEPAPAGTLPAPDARDAVITVDRLVVRHEGRDVPSLAETSFEVRPGETVAVTGASGVGKSTLLSVLLGLERPTGGRVSVGGADLSSLSPESWRDQVAWVPQRPHLFAGTVAENVRLTRPDATDTQVREALRAAGALEFVSMLPHGTDTRLGEDGAGLSAGQRQRVALARAFLADRPVLLLDEPTANLDGETEAAVVAAVRRLAEGRTVVLVVHRPALLAVADRTVRLGGRPAGARPAGAEPADRSGGREERPAAPRGAPTEAPLVAGAGTPGQPAPDRPAGALSRVRAAGRPLRGRFTLALVLGALALGSAVGLMAVSGWLISRASQQPPVLYLMVAVTATRAFGIGRSVFRYTERLVSHDAVLRVLAGLRVSVYRRLERLAPAGLRETRRGDLLARLVADVDTLQDYFLRWLLPLGSAVIVGVASVGFTAWLLPEAGAALAVGLLVAGPGAAVLAVTFARRAERQLAPARGELAGHVVELMTGTAELTVAGALPGRLERLRRADRTLTRIARRTSAATALGAGVSALACGLTVAAAAWAGVGAVRDGRLGGVWLAVVVLIPLAAFEAVAGLPLAVQYRRRVQRSAERVYEVLDAPEPVREGTGPAPRSPFPLRLAGLTARHPGQSVPALDDVGMELTAGRRIAVVGRSGSGKTTLAQVLLRFLDAEAGAYTLGGEDTAGMDGDGVRRLVGLCAQDAHLFDSSVRENLRLARPGADDEALREALRAARLLDWVDGLPQGLDTLVGEHGARMSGGQRQRLALARALLADFPVLVLDEPAEHLDLETADALTADLLSATEGRTTVLITHRLTGLEAVDEILVLERGRVVQRGAYETLAGAPGPFRRMLDREAAADAERVAAARPEARVDPVAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHC4</accession>
    <name>A0A2G1XHC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17695</name>
        <name evidence="4" type="ORF">CYQ11_15580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="PPT14115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50630">
        <property type="protein sequence ID" value="PHQ50630"/>
        <property type="gene ID" value="BLA24_17695"/>
    </dbReference>
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        <property type="protein sequence ID" value="PPT14115"/>
        <property type="gene ID" value="CYQ11_15580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
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            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="29844" checksum="E4474A11ADCFDD73" modified="2018-01-31" version="1">MHMNSAPHLLAEDRPEFERVLDHALRTANHDPELATAIGQRLNTEQLRTMALSAMAAISACATAEYENFVTVREELRARSSAPGDGDGGSDDTPSPAMAGPEDPGAGAGAVVAVLAPVLAGIAAFLFLLIGYVMRLVGAGEGAADSMITVGWWFGGFTVAGVLVAMAGMLLTALRNGPHPEEAPPADLLAAEADRAREAWRQALLERGVRPFLREALANGSGPPRSSYAARHQEGPGRTPQLGYSRPGFSSPDNRADTSNRPRYTSPDYTSPDFGNTDHRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHE7</accession>
    <name>A0A2G1XHE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanine--glyoxylate aminotransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_17785</name>
        <name evidence="5" type="ORF">CYQ11_15490</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50647">
        <property type="protein sequence ID" value="PHQ50647"/>
        <property type="gene ID" value="BLA24_17785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14098">
        <property type="protein sequence ID" value="PPT14098"/>
        <property type="gene ID" value="CYQ11_15490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="79"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="375" mass="38667" checksum="CC235CA7255586CB" modified="2018-01-31" version="1">MTANTAPDLLDLPPLGAGHFARIEDKVAALMRTRETVVTMQGEALLPLEACIRSAVRPGSTALNVITGPYGETFGGWLRSCGAEVITVTAPFSGAVTPEQVAEALRAHPAIDFVSLVHAEAATGNTNPVAGIAEVVREHGALLMLDAVASVGAEPLLTDEWGVDLCVIGGQKAMAGPAGVSVVSVSARAWERIAANEQAPRRSYLSLLDWKERWIDGGRAALPHAPAQLEMLALEQAADRVERAGLDAVIARHRAAAAATRAGVRVLGGVTPYVVRDEDAAPVATTLRAPEGTDARDIVAAALAADACVPVQAAGGALAKEMVRVNHYGLEADREVVLATVSALAEGLRALGVPVAEPGEAVVAAGKAWDAVIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHH4</accession>
    <name>A0A2G1XHH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17440</name>
        <name evidence="3" type="ORF">CYQ11_15835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50589">
        <property type="protein sequence ID" value="PHQ50589"/>
        <property type="gene ID" value="BLA24_17440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14156">
        <property type="protein sequence ID" value="PPT14156"/>
        <property type="gene ID" value="CYQ11_15835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044058">
        <property type="entry name" value="Lipoprotein_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18966">
        <property type="entry name" value="Lipoprotein_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23181" checksum="154EB90303F5E188" modified="2018-01-31" version="1">MSTVLALGVLTGCSSAGDKDGGAPQAVEASAGTAEEGVKPKASAKPTETARPKAAPKDGRIGDAGTTCVLPVSFEAPKEWKLTGVSDEDAELFRKVFGHPTLKGACELSARPTGVIGFIRVWTTDRPDASPRQVLEEFVAEEKGVSDPEYSELTLGGLPAVEVVYTQRSVLLDEPTRRRDIAVKAPKGVTVLHVDGVESEDAKVVIPGYELVKKTMRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK0</accession>
    <name>A0A2G1XHK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18140</name>
        <name evidence="4" type="ORF">CYQ11_15135</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50706">
        <property type="protein sequence ID" value="PHQ50706"/>
        <property type="gene ID" value="BLA24_18140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14040">
        <property type="protein sequence ID" value="PPT14040"/>
        <property type="gene ID" value="CYQ11_15135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="158" mass="16504" checksum="88427004629D4B19" modified="2018-01-31" version="1">MASSEWSSEAVETDLTQTEGLPSQRGRSVDDGGIADALRAATDDASSREVSEVEVSSLFQTPLFRFEGKFRTNGEESSPANRSIAAALVVVLAMAGGLAFAWIFLGAVDAGVVMTWTLVIIAAGFVLAWRLGHERPESKSPGAGEPPAGPRGEGPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHN7</accession>
    <name>A0A2G1XHN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18355</name>
        <name evidence="4" type="ORF">CYQ11_14925</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50743">
        <property type="protein sequence ID" value="PHQ50743"/>
        <property type="gene ID" value="BLA24_18355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14000">
        <property type="protein sequence ID" value="PPT14000"/>
        <property type="gene ID" value="CYQ11_14925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="27598" checksum="2F6CC1BB28D4115F" modified="2018-01-31" version="1">MRASLIQFEVRPDDPVAARRERAAELVRRQRGSDLVVLPELWPVGAFAYESFAAEAESLDGPTAAAMAAAARDAGVWLHAGSVVERAADGTLYNTSLVFSPSGELAAAYRKIHRFGFDKGEAVLMGAGAEPVTVRLPDTTLGLATCYDLRFPELFRALVDAGAQVFVVPAGWPERRRDHWTLLARARAVENQAYVLACGTAGTHAGVGQAGHSVVVDPWGEVVAQAGAGEEVLVADLDPARVGKVREDFPALKDRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHS3</accession>
    <name>A0A2G1XHS3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrilase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18655</name>
        <name evidence="3" type="ORF">CYQ11_14625</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50792">
        <property type="protein sequence ID" value="PHQ50792"/>
        <property type="gene ID" value="BLA24_18655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13950">
        <property type="protein sequence ID" value="PPT13950"/>
        <property type="gene ID" value="CYQ11_14625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="134" mass="14536" checksum="EF88218BECF469F3" modified="2018-01-31" version="1">MAIDPRNPDPAYAAFWRERHVCTLTTPRPDGSPHVVPVGVTYDPATGTARVITGKDSRKVANVQAAGPDGARVAVCQMEGKRWATLEGRAVVRTEADVVADAVERYAVRYGRTPRPNPDRVVIEITVTRAMGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHV6</accession>
    <name>A0A2G1XHV6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50709">
        <property type="protein sequence ID" value="PHQ50709"/>
        <property type="gene ID" value="BLA24_18155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="270" mass="29485" checksum="9EE39EA39D9E5BE5" modified="2018-01-31" version="1">MTNPEADISEEPGTERLAAAVRAAEQALIEFEIAVETFRVEVENFSRLHHQRLGPMYARLDELEARIAEAVAARTGDAEDLRRAREARALVQPLPGVEELFGGWMDDQGLSPEASAMLTERPVSPPKRVRPSEEARRAYRDLVRKAHPDLALDEADRLRREAFIVRVNAAYGDGNAALLAELAGEWAAGPVPGQRRASRSEELYARLEWLAERKELLSAVAAELEASAIGAMIKMAPEDPDGLLAEISDGLLAQIAEREAHLAELLGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHZ7</accession>
    <name>A0A2G1XHZ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protease PrsW</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">PrsW family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19020</name>
        <name evidence="4" type="ORF">CYQ11_14260</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50847">
        <property type="protein sequence ID" value="PHQ50847"/>
        <property type="gene ID" value="BLA24_19020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13895">
        <property type="protein sequence ID" value="PPT13895"/>
        <property type="gene ID" value="CYQ11_14260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="458" mass="49995" checksum="21A5579DD48C33C8" modified="2018-01-31" version="1">MHDSPPPLPQHQPPSPPTAWQHYKPRRALWDTLWDNKAVRAGGVFLLLALCGLIILALVREQTGTQGFLVGLGLAVLPVPLLIAAFRWMDRVEPKPWRNLIFAFAWGACAATLVALLANGYATKWLLNTVDVAREDDASAWGATFVAPVVEESGKAAAVLLLYLFRRRDFNGIVDGVVIAGITATGFAFTENILYLGNAYASDQSFGYSGLPSTTAATFFLRVLMSPFAHPLFTSLTGLGFGIAATLAPRRRVLRCVVPVLALLTAMLLHGIWNGSASLPGAGFMAVYILFMVPVFGVLTWLTIWSRQNELRTIRSHLPAYQAAGWLTPPEPFALSSMRARGIARDVARRSGGSASARTVAEYISFATSLAFLRERAYRGAPDPDFTAREQELLHHLWQRKDTAQPALAQAIAATPRPPTPHPFYVPPTHPWPAQPWPTQPTPPAPGPGWPQTPGQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI19</accession>
    <name>A0A2G1XI19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17260</name>
        <name evidence="3" type="ORF">CYQ11_16015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50876">
        <property type="protein sequence ID" value="PHQ50876"/>
        <property type="gene ID" value="BLA24_17260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16596">
        <property type="protein sequence ID" value="PPT16596"/>
        <property type="gene ID" value="CYQ11_16015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="9701" checksum="C2CF78E97A1C6E5E" modified="2018-01-31" version="1">MKKARAPREPEGPAARGKPARPERMEKPEDGSESSEDRRRRRAQFLRELNEAKELRDRVQPRRARAARMRQQMRMRTFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI95</accession>
    <name>A0A2G1XI95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19030</name>
        <name evidence="4" type="ORF">CYQ11_14250</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50849">
        <property type="protein sequence ID" value="PHQ50849"/>
        <property type="gene ID" value="BLA24_19030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13893">
        <property type="protein sequence ID" value="PPT13893"/>
        <property type="gene ID" value="CYQ11_14250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758483" evidence="1">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="39"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="34809" checksum="7FFDE07FF6EA4419" modified="2018-01-31" version="1">MRLRMRRRLRSGHRPRARARLLTALAVGAALTGGCSPARGGSDEVVPAAQVAEPARGARNGWRLVWSDEFQGAAHSRPDRRTWVFDRGGEPQWGNHEWQYYTDRPGNASLDGRGDLVLTARRERLRGMVCSVGPCNITSGRMTTKGRYARAYGRFEARIRVPRGQGLWPAFWMLGANSDKVRWPGNGEIDVMEVVGRQPGTVHGSVHGPGYVKQGIEKHTALAHGRSLADGFHTYRVDWMPDRIVWYLDDKPYGVARSGRLRRGQKWVFDHPHYLLLNLAVGGDWPGPPDRKTPFPARMVVDYVRVYAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIH9</accession>
    <name>A0A2G1XIH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4229 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14160</name>
        <name evidence="3" type="ORF">CYQ11_13915</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50939">
        <property type="protein sequence ID" value="PHQ50939"/>
        <property type="gene ID" value="BLA24_14160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13840">
        <property type="protein sequence ID" value="PPT13840"/>
        <property type="gene ID" value="CYQ11_13915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025323">
        <property type="entry name" value="DUF4229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14012">
        <property type="entry name" value="DUF4229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="10779" checksum="AA1C0F1E5F0AD39C" modified="2018-01-31" version="1">MSTASSHKYASLRYTASRIGLLVACFAVVWVLCYAHLIPIGVNGSNIFWMLLLALVISGPLSFVLLRKQRDAMSVQISHRVDRAKERFAANAGQEDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIN0</accession>
    <name>A0A2G1XIN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15030</name>
        <name evidence="2" type="ORF">CYQ11_13040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51087">
        <property type="protein sequence ID" value="PHQ51087"/>
        <property type="gene ID" value="BLA24_15030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13690">
        <property type="protein sequence ID" value="PPT13690"/>
        <property type="gene ID" value="CYQ11_13040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="26338" checksum="150943D3695727D4" modified="2018-01-31" version="1">MTFLQVIDCKTSRFDDMDRLMDDWVTATEGKRTATHSIVGRDRSAGDHYVEIIEFPSYEEAMKNSNLPETNRIFEEMVALCDGLPSFTDLDVVRDEQLNKATARRFFEDVAVRGDLELVDELCTADYRDHDVAKAEETVVGCEALKEDVAGWRAAFDFAFSLHCQLAEGDQVSTHWSWRGTHQGDFMGLQPTGQEVTMDGVTIHRFRDGRIAEGWWIFDMLGLMRQLGAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIY9</accession>
    <name>A0A2G1XIY9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BLA24_15770</name>
        <name evidence="17" type="ORF">CYQ11_12305</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51212">
        <property type="protein sequence ID" value="PHQ51212"/>
        <property type="gene ID" value="BLA24_15770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13564">
        <property type="protein sequence ID" value="PPT13564"/>
        <property type="gene ID" value="CYQ11_12305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="14">
        <location>
            <begin position="81"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="15">
        <location>
            <begin position="393"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ51212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="587" mass="64999" checksum="5941388BE01A082E" modified="2018-01-31" version="1">MSSDTATQARQGRTAAEQPPPWQRRLRRFGYAGRPAHPDVRERLVPPYPEPGTRLWAAAGAGPGLARLLARSMGWLGPLLVALFAGLIRFWHLGSPKAVIFDETYYAKDAWALWKYGYEVNWPKEANDQIVAGHTDVADAAAYVVHPPVGKWVIGAGEWLFGLDPFGWRFMVALLGTLSVLMLCRIGRRLFRSTFLGCLAGGLLAVDGLHFVMSRTSLLDSVLMFFVLGAFGCLLVDRDKARARLAAALPEGPDGTVPPDARAGDGTRLGLRPWRLAAGVLLGLAFATKWNGAVYLAAFGLMAVLWDVGSRRLAGARRPWLSTLRRDVPWAFLATVPVALGVYLASWTGWFVNSGTYDKTAGWQHSGYLRHYAETEGGQSADGLLAGILNPLRSLWHYEKQVWEFNTHLTSPHTYQSNPWSWLVQSRPVSYFYESPAAGQDGCPADAADKCAREVLALGTPLLWWAACFALVYLLYRWALRRDWRAGAVLGAVAAGYLPWFLYQERTIFVFYAVVFVPFLCLAVALLIGALLGPPGSSERRRVAGAVGAGTLVLLIAWNFIYFFPIYTGQAIPMDAWRNRMWFDTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIZ9</accession>
    <name>A0A2G1XIZ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">galT</name>
        <name evidence="16" type="ORF">BLA24_15855</name>
        <name evidence="17" type="ORF">CYQ11_12220</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51228">
        <property type="protein sequence ID" value="PHQ51228"/>
        <property type="gene ID" value="BLA24_15855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13548">
        <property type="protein sequence ID" value="PPT13548"/>
        <property type="gene ID" value="CYQ11_12220"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="197"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ51228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="348" mass="38926" checksum="E2D4F8CD7E395C15" modified="2018-01-31" version="1">MKKTATRLADGRELLYYDSRDDVVRTAADRRPLPPAASTGEIRRDPLLGDDVVIASHRQARTYHPPPGECPLCPSRDGRTTEIPADDYEVVVFENRFPSLAGDTGRCEVVCFTADHDASFAALDEDRAALVLAVWTDRTAALAALDTVEQVFCFENRGHEMGVTLGHPHGQVYGYPFVTPRTATTLARAAAHRERTGGRNLFDDTVAAERADGRRIVLEGAHWTAFVPHAARWPYEVHLHPRRRVPDLLALDDAARTEFPQIYLELLRRFDRIFGPGRPPTPYVSAWHQAPLQHPHRTEFALHLELFTIRRTAGKLKFLAGSESGMNVFINDVPPETAAERLREVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ03</accession>
    <name>A0A2G1XJ03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_15725</name>
        <name evidence="10" type="ORF">CYQ11_12350</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51203">
        <property type="protein sequence ID" value="PHQ51203"/>
        <property type="gene ID" value="BLA24_15725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13573">
        <property type="protein sequence ID" value="PPT13573"/>
        <property type="gene ID" value="CYQ11_12350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758866" evidence="7">
        <location>
            <begin position="41"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="194"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="734" mass="75949" checksum="90B66042CA1C00F8" modified="2018-01-31" version="1">MATFLYKLGRLAFRRRWYVALTWVLLLVLAGAGAATASKATDNFSIPGTEAQRAFDLLEKRMPDMKADAATARIVFKAPGGQKITDPGNKAAVDKVVGALGGPQVAAVADPFAGDGVSKNGDIAYASVTYKVKANELTDDTRDKLKAAPDAGRDAGLTVETGGSALQAMPEGGSTEIIGIAISAVVLLITFGSLVAAGLPLLTAIIGVGIGVSSIAAVASALDLGNNTATLATMIGLAVGIDYALFIVSRYRAEIAEGREREDAAGRAVGTAGSAVVFAGLTVVIALAGLAVVNIPMLTKMGVAAAFTVAIAVLIALTLIPALLGFAGRKVLARKVRKAEGTDVSAEQKPNMGTRWARLVLRRPVVVLLAGVLGLGAIAVPAGSLMLGLPDEGSQPQSTTQRKAYDLLSEGFGPGFNGPLMLVVDAAHSKDHQAAAESVVNTVKGLDDVAVVTPAHFNEAGDTAIITVVPKSKPSGSETEDLVHAIRDKGRAAGSEAGAEVLVTGTTAVNIDVSQKLNDALLPYLALVVGLAFLLLMVVFRSVLVPLKAALGFLLSVVAALGAVVAVFQWGWLGGLFGVEETGPIMSMMPIFMVGVVFGLAMDYEVFLVTRMREAYVHGERPGEAVVTGFRHGARVVTAAAVIMISVFAGFIGSSEPMIKMIGFGLAIAVFFDAFVVRMAIVPAVLALLGRSAWWLPGWLAKALPNVDVEGEGLQKSLKAPAAESDEDREPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ11</accession>
    <name>A0A2G1XJ11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_15655</name>
        <name evidence="7" type="ORF">CYQ11_12420</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51190">
        <property type="protein sequence ID" value="PHQ51190"/>
        <property type="gene ID" value="BLA24_15655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13586">
        <property type="protein sequence ID" value="PPT13586"/>
        <property type="gene ID" value="CYQ11_12420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="PTHR12872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304891" evidence="2">
        <location>
            <begin position="27"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU_N" evidence="4">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU" evidence="3">
        <location>
            <begin position="130"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU_C" evidence="5">
        <location>
            <begin position="459"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="727" mass="81068" checksum="9EA35E6BCCDCA1EE" modified="2018-01-31" version="1">MHIARRTLLGALAGSAALGAVGAAPAAGAPAAPGGAAAAALARLLPRHHRQVVFRPLPRRDGDDAFRVSGQEGRVTVEGSTPAVQLTGFHWYLRQTADAHFSWCGEQTALPDKLPGLRAPLVRNANVRHRFALNDTNDGYTGPYHGWDYWEREIDVLALHGFNEVLVYAGADAVYHRTFIEHGYSDADVRRWVPGPAHQPWWLMQNMASFGGPVSRELLDRRVALAQRIVRRLRELGMTPVFPGYYGTVPPDFERRNEGARVIAQGDWQGFPRPGWLDPRTPHFTRVARTFYRVQQELYGPTSMYKMDLLHEGGSPGDVPVGDAARAVEKALRTAHPAATWAILGWQKNPRREIVEAVDRSRMLVLDGIPDHYPNVTDREADWDGTPYAFGTIWNFGGHTVMGANTRDWADLYHRWRTKDGSALSGIALMPEAADNNPAALALFGDLAWTDGPVDLADWFGHWPRYRYGGADANAVRAWEVLRRTAYGCTRADGWGEQADGLFGARPDLAVNRAGSWSPRTLRYDPDEFDRALPALLAVAPALRGSSAYRHDLMDVARQSVANRSRLLLPRIKAAYDARDRGRLGELTRQWLDWMGLLEEVVATDERHLLGRWLADARAWGSTPAERDRLAVDALSLLTVWGPRASANGGKLHDYANREWSGLVGGLYRLRWKTYFAELDASLAAGRKPRQIDWYALEERWTRQPPAVRTKPSGDVVRIARTVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJS8</accession>
    <name>A0A2G1XJS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51460">
        <property type="protein sequence ID" value="PHQ51460"/>
        <property type="gene ID" value="BLA24_13155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="64" mass="6263" checksum="12DEF2F3095B57DD" modified="2018-01-31" version="1">MANGRLPLFGEAAVFAGRSSARAVEPPGPGAAPTSSPAASRAEAKVGADRAGRTSGRRDGGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK49</accession>
    <name>A0A2G1XK49_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13505</name>
        <name evidence="4" type="ORF">CYQ11_01225</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51519">
        <property type="protein sequence ID" value="PHQ51519"/>
        <property type="gene ID" value="BLA24_13505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11701">
        <property type="protein sequence ID" value="PPT11701"/>
        <property type="gene ID" value="CYQ11_01225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="275" mass="30956" checksum="801D776423D51828" modified="2018-01-31" version="1">MPKNPHQRRELGAFLRSRRERTTPEQVGLPRSSRRRTPGLRREELALLAGISATWYTYLEQGRDIRASDQVLDALASTLRLDRNERAHLRQLAGHAPAVEIEEPEQLTAAVAAVPLLLQPNPAYVIDGTYDVLSLNPAADELFPHLTSAGDRRANMARWVFLEPAAREVLADWEAEARGLLARLRTLAGRHHDDTRYTTLIDELTAASPEARTWWPRHDVQARHSGRKRLRRPGHGVTTFAYTAFHVAERPEHTLVIYTSEQEATPTGGRAADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK87</accession>
    <name>A0A2G1XK87_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12640</name>
        <name evidence="5" type="ORF">CYQ11_17015</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000142">
        <property type="protein sequence ID" value="PHQ51636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51636">
        <property type="protein sequence ID" value="PHQ51636"/>
        <property type="gene ID" value="BLA24_12640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14340">
        <property type="protein sequence ID" value="PPT14340"/>
        <property type="gene ID" value="CYQ11_17015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="291"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="393" mass="41811" checksum="F3AFFA662B6D70BC" modified="2018-01-31" version="1">MPRSFLRRLRTSGPWAVDALITVVVQAAVTIPFVVPRSADVPPATWAAYGMTTLGVLPLLWRSRAPLGSLLGITVAGLAYLPLDGPGQPMPYAPLVALFTVAAQGGLWQRRVTIGLGLPLVAVAVALRTNTAREYLFAFFLFSMVYVLGVLTRTRQAYTEAVELRAAELEKARQVEAERAAERERARIAREMHDVLSHAVSLMIVQAEAGPLVVRSDPDRAEAAFDAIAGAGRDAMVQLRRMLGVLKDEPGGTRSPQPTLEDLDDLVAEVRRTGLRVDLVARGEPRALGPDVQVTVYRVVQEALTNVLKHAVAASVDVRLTWLPDRLEVSVEDDGEKEAGAPAAAGGGGRGLVGIRERAAAHGGTAVFGPGPGGLGFRVAVELPLVVCSPAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKD6</accession>
    <name>A0A2G1XKD6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cysteine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11400</name>
        <name evidence="5" type="ORF">CYQ11_02635</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51692">
        <property type="protein sequence ID" value="PHQ51692"/>
        <property type="gene ID" value="BLA24_11400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11941">
        <property type="protein sequence ID" value="PPT11941"/>
        <property type="gene ID" value="CYQ11_02635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="344" mass="36535" checksum="AF6EF9FBC3F34E45" modified="2018-01-31" version="1">MNEALIRPAVVSRVSELIGHTPLFELCRTPEGSRLLLKLEMYNPTGTAKIRMARQMVLDAEERGALRPGGRIIESTSGNTGLGLAVVAAERGYSFTAVVDHHACSDKLRTMRALGAELVYVTGDGTGELATAAREELAEELARGQDNAVFTEQHNNPANAVGYHPVAHELHQALDGRVDVLIGAVGTGGGLCGTARELRGLLPDVRTVGVEPKGSIAFGGPAHDYYQSGTGTPEGAEIGALVDFDLIDEGVKVGDVEAFATARAVARTGLLVGGSAGGVVYEALRRLPALPPGTTVVALVNDGGEKYLDTVFHDEWMKERDLLDPVLEHEIHGIVTGWRGDRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKE8</accession>
    <name>A0A2G1XKE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Type 1 glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11530</name>
        <name evidence="4" type="ORF">CYQ11_02765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51715">
        <property type="protein sequence ID" value="PHQ51715"/>
        <property type="gene ID" value="BLA24_11530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11964">
        <property type="protein sequence ID" value="PPT11964"/>
        <property type="gene ID" value="CYQ11_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="182" mass="19379" checksum="205AF131DD886EB0" modified="2018-01-31" version="1">MKVAFLVAPEGVEQIELTSPWKAVQDAGGTAHLVSTKPGKVQAFHHLDRGDAFPVDTVVGEVGAPDYDALVLPGGVANPDFLRMDERAVAFVRDFFTSGKPVAAICHAPWTLVEADVLRGRTLTSWPSLRTDVQNAGGSWVDEQVKVCASGPNTLITSRKPDDLKAFCEAFVEEFGKAGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKK3</accession>
    <name>A0A2G1XKK3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11820</name>
        <name evidence="3" type="ORF">CYQ11_03060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51765">
        <property type="protein sequence ID" value="PHQ51765"/>
        <property type="gene ID" value="BLA24_11820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12012">
        <property type="protein sequence ID" value="PPT12012"/>
        <property type="gene ID" value="CYQ11_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304965" evidence="1">
        <location>
            <begin position="29"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="722" mass="77380" checksum="F6B5EFD1AF913254" modified="2018-01-31" version="1">MGRTTRLVAAWATTVFLAMALPSAEAGAADAAPRIDLRLLVVDDGGPAVEAIRAELDGDGTPYTRVDLDAAGRPRIDEAFLSDTVEGRPRAKFQGVILPNDNPFGSAAESEALAGYEKRFGIRQVDAYTYARPAVGLNVPADGGYAGPLDGQTAQVTQAGAAGPFGYLRRNVPFEDNDGTVNESYGYVAVPLERQADGASYTSFVDAPVPGRSGRGSLIGQYTHDGRSELVVTFVANQYQTQFRLVARGIVEWVTQGVHLGAARNYFGVHADDVFASDDRWDTKRKCTPGDVDCPGNPSPDSPPIRMTAADAQYAKEWSRSHGLTLDLAYNGVGSEEYRSEHGGLPDPLLQQLLADQKSYRWINHTYTHAFLGCEQNTTVVPWKCATDLFGRTRWVSGPTIGYQVDENLRWAARQGLALDKDELVTGEHSGLKTLPQQTVDNPELAPVLSRSGVSWIASDTSRERQQRPVGTALTVPRYPMNVYYNVGRAAEQTDEYNWLYTKKADGGSGVCEKYPETTTCLKAPLDVRTGFASYIAPLESRIALGHALANDPRPHFMHQSNLSEERIGYTVLEKVLADYSGLFADNTPLVNLRMRDIGAELAKRASWTSALAAGKVTAYRIGNAVTVTTPAGVQAGLTLPDGTVEQGTGTAFGSPYAGARSGWAAPGAGQAQLALTLPAAAPAAPVLTGKAARVQAPAAALPVPRGVTHRVPYGPSDTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKZ9</accession>
    <name>A0A2G1XKZ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10805</name>
        <name evidence="4" type="ORF">CYQ11_00745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51934">
        <property type="protein sequence ID" value="PHQ51934"/>
        <property type="gene ID" value="BLA24_10805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11621">
        <property type="protein sequence ID" value="PPT11621"/>
        <property type="gene ID" value="CYQ11_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="296"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="39093" checksum="4EC4F2FBE9676A64" modified="2018-01-31" version="1">MNSAPTRVVVVGAGLGGLALARVLQLHGRSVTVFESEASNGARPQGGSLDIHAATGQAALRAAGLLDRFRALARPNAQEWRVLDPVTATAVPFPGPVHDDDSPEIDRGQLRGLFLESLAEGSVRWGRTVTGATPLGDGTWRLLLDDGTSEDADLVVGADGAWSRIRPALSDATPSYTGVTFIETGFDDCDTRHPALARMVGNGTLLAAADSKALLAQRNSNGHLRVYIAFRAPQDWRTAAGLELHDTAAVRAHLLKMFDGWDESLLYLLRHHDGGFVDRPVFVLPVPHTWDHVPGITLLGDAAHLMPPVGLGANLAMLDGTDLAHALVTESSIDDAVRAYESRMLPRSAQAAEDCAKALDSLIPPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLI3</accession>
    <name>A0A2G1XLI3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09300</name>
        <name evidence="3" type="ORF">CYQ11_27910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52108">
        <property type="protein sequence ID" value="PHQ52108"/>
        <property type="gene ID" value="BLA24_09300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16188">
        <property type="protein sequence ID" value="PPT16188"/>
        <property type="gene ID" value="CYQ11_27910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="414" mass="43793" checksum="2D4A884495675430" modified="2018-01-31" version="1">MYIQIITAGTTGSVAPYTGLAHRLAAEGHDVEIVTHAKFTELVSCCGMRMRPLAADPFEELIGAHGRFRDAGRSPAALRGFVRATERAALSLVDGILAAVDPKADLLLLSSIAAPIGQVVARYHGIPSMGAFLQPDAPTAAFPPCTMPLRPPGFGNRLRGAAANAVLDALYAAAHRSLHVRLGLARRGGHRLRRERERGRWPIWHGFSPSVVPRPADWRPGLRVAGYWWPHECPTWQPPALVGEFLAAGPPPVFVGFGSMMPGDPDRLAGITARALRRAGLRGVVQSGWAGLSVMNDDVITVGPLPHGWLMPRMAAVVHHAGAGTTAAGLRAGVPAVPVPVFTDQPWWAARLVRLGVSPEALPLAGLTAERLAGALGRATGEPRFARRAVELAGRLGREDGAGTVARAVAEMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLI7</accession>
    <name>A0A2G1XLI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09115</name>
        <name evidence="4" type="ORF">CYQ11_27725</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52076">
        <property type="protein sequence ID" value="PHQ52076"/>
        <property type="gene ID" value="BLA24_09115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16156">
        <property type="protein sequence ID" value="PPT16156"/>
        <property type="gene ID" value="CYQ11_27725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="8414" checksum="D1547B84737F6233" modified="2018-01-31" version="1">MAAKPRYVPSGSAPPALRGARWHRSSHSTGMNNCVEAARVGRTLAVRDSKRSAGPVLLFSPAAWSAFLAGLRGPHGCARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLQ8</accession>
    <name>A0A2G1XLQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL family lipase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09070</name>
        <name evidence="4" type="ORF">CYQ11_27680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52173">
        <property type="protein sequence ID" value="PHQ52173"/>
        <property type="gene ID" value="BLA24_09070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16838">
        <property type="protein sequence ID" value="PPT16838"/>
        <property type="gene ID" value="CYQ11_27680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="29452" checksum="CC370B9CF71E3FCD" modified="2018-01-31" version="1">MGASYTHPYTSFVAIGDSFTEGMSDGLPDGSYRGWADLLAARLAERTAGFRYANLAVRGKLIGQIADEQAAPAAAMGADLVTLVGGLNDVLRPQCDVDLVCARLAEAADLLAPSCRQLVLMRSPGRRGPVLERFRPRMEQLFGFVDELAERHGALVVDLFSAEALGDSRLWADDRLHLNAEGHRRVAEAVWQALGHAPESDWREPLPPLVRPGWAVRRTADLRFAREHLVPWIGRRLTGRSSGDGRPPKRAELLPYEPLPLPQNGSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLS5</accession>
    <name>A0A2G1XLS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_09275</name>
        <name evidence="9" type="ORF">CYQ11_27885</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52177">
        <property type="protein sequence ID" value="PHQ52177"/>
        <property type="gene ID" value="BLA24_09275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16842">
        <property type="protein sequence ID" value="PPT16842"/>
        <property type="gene ID" value="CYQ11_27885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="428" mass="43395" checksum="C5CBC0EDA70B039D" modified="2018-01-31" version="1">MAVSLTGTRVSAVALPWFVLVSTGSATRTGLVAFCEMAPYVVVQALSGPLVDKAGPRRVSWNADLLSAVAAAFVPALHVLGLLPFWLLLGLVAVIGVVRGPGDLAKTVMVPEAAERGGLPVERATGLAGVTERLASTVGPAVAGALVALVGPLAGLAVNAACFALGSLVVGVLMPRDVGRATETGDGTRQTREPAGYWRRLGEGFSFLRGDRLLLGITVTVGVTNLLNTAFSSVLLPVWAKESGGGPAVIGLTGSVAGVAAVCGSLIAAAVAHRLRRRLVFFAGFLLDGAPRFLILACGAPMWAVAAVFAVSGFGGGFLNPILGAVLYERVPRGLLGRVKALGSALAWAGIPFGGLLAGAAVTTAGLVPALVAGGAAHAVTISLSGLRPEWKAMDRSRRSRSTGGEEPPRESAEDEATGRQPEAPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLT4</accession>
    <name>A0A2G1XLT4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52170">
        <property type="protein sequence ID" value="PHQ52170"/>
        <property type="gene ID" value="BLA24_09655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="154" mass="17389" checksum="364C5949A125CD8C" modified="2018-01-31" version="1">MADQDSGDVYVLPFALAFDTRERLDGFLTALQWVVDRHDIYRTAIVWEGLREPVQVVARHVDLPVTEIVLDEEGPEPVDQLLQAAGSWMDLRCAPLLRMTVAAEAGADGRWLALLRLHHIMQDHTALDVLLGELRAFLTGTRRRCRSRCRSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM14</accession>
    <name>A0A2G1XM14_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08550</name>
        <name evidence="3" type="ORF">CYQ11_03805</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52278">
        <property type="protein sequence ID" value="PHQ52278"/>
        <property type="gene ID" value="BLA24_08550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16333">
        <property type="protein sequence ID" value="PPT16333"/>
        <property type="gene ID" value="CYQ11_03805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="130"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="29580" checksum="6FDF9825048EEF75" modified="2018-01-31" version="1">MTMAVVSAVHCYPVKSMAGCAPGEAAVEPWGLAGDRRWMLAGPDARVLTQRQEPRLTLASARPLPGGGVRLTTPGAAPLDVRVPTADGQGGTLTVELFRDKVETVPAGAAADAWLSAFLGTDARLVYMDDPARRRPVDPEHSLPGDTVSFADGYPLLITATASLEALNSLIAEGDRAAEGPLPMDRFRPNVVVDGTPPWAEDGWRRVRLGEVTFRVAKPSGRCVVTTTDQRTAVRGKEPLRTLARHHRIGAKAVFGQNLIPEHTGVVRVGDAFEVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMC0</accession>
    <name>A0A2G1XMC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_07895</name>
        <name evidence="9" type="ORF">CYQ11_00330</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52363">
        <property type="protein sequence ID" value="PHQ52363"/>
        <property type="gene ID" value="BLA24_07895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11566">
        <property type="protein sequence ID" value="PPT11566"/>
        <property type="gene ID" value="CYQ11_00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="22634" checksum="8CE74370DF07DBBB" modified="2018-01-31" version="1">MNQRFTWPDERLIKAAQDGDVTSLTTVVMESQPHVRRFAISLCSSPQDAEDAAQEALIILYRKIGTLRATGALASWMFRIVRNECLRQVRLLVSQNDEATAEPQATAEPSAEDAVLHRLEAERIAAAVSALPRDQRQVLIMRDVQGLPSKTVAHSLGLSSAAMKSRLHRARAALRHSLAVTDQPLGQAADEARDQAIDQPVGGVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMF0</accession>
    <name>A0A2G1XMF0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07635</name>
        <name evidence="3" type="ORF">CYQ11_00065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52408">
        <property type="protein sequence ID" value="PHQ52408"/>
        <property type="gene ID" value="BLA24_07635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16253">
        <property type="protein sequence ID" value="PPT16253"/>
        <property type="gene ID" value="CYQ11_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="359" mass="39403" checksum="64271B170F52EE78" modified="2018-01-31" version="1">MVIDRDDDVIHTHTALAAHHPPSGRITLHPGPGTTSETGLAHDLLAALGKPPLLTGRFPAGRQPAWEAAAAWMTALPVTRLTVLRAHRLTTRRTIRLLELRALTGIHLTLVCHRLHLPAALHQALRTVDYSLTTDLDAARRHYYGTPVTEPPPADEPAGPAGRWLTLSALERLISYDSPRPCTDPCTPPSIAWRHRPPPVPLTAHTAQRIAHRLHAATAHPRLAAAIAATLFTGASLQQLATARPRDYDTAAATLALHDRARYTDGCAAHPVPPWASVFLRAAACFTRLVSGEDQELLAAPGDRAHLLRVAETARLRPPQPPAERRKGPVGQVDWDWRERQEAERYEAMPANRVRPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX4</accession>
    <name>A0A2G1XMX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_07265</name>
        <name evidence="10" type="ORF">CYQ11_27420</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52560">
        <property type="protein sequence ID" value="PHQ52560"/>
        <property type="gene ID" value="BLA24_07265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16098">
        <property type="protein sequence ID" value="PPT16098"/>
        <property type="gene ID" value="CYQ11_27420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="37"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="334"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="602" mass="63128" checksum="C9CEB26709F18A05" modified="2018-01-31" version="1">MQIRDLPYADPGRPDVRSGPRFLYWLGRNQLGGQLRSLFWGVVHSGSVALFPLAVGMGVAAVVDRSGARLAAAGGLLLLLGALTALGDTMLHRTAVTNWITAAARVQQLLARKTAELGSALTRRVAAGEVVAVSTGDVEKIGWFVEALSRFVAAAFTTLVVCVALLVYQPALGAVVAAGVPLMALAVLPLLPPATKRADEQREKAGRATELASDTVAGLRVLRGIGGEELFLSRYRSASQEVRRAAVRSARMWALIAAVQVVLPGLLMIAVVWYGALLARDGRIGVGELVTVYGVVTFLLFPLRQFEEIAMAYSFSRPSAQRAAKVLALRRTAVPADDVEAVAGDLKGDLYDPATGLLARSGELTAVVVGDPDAAGRLADRLGGHAAEGAGDSPSVLLGGVALDEVPLDVARTAVLVQDKDPVLLSGTLTELLDVPSSGAVTADAALTAARCDDVLASLAQASPDGSGDPLRTRITERGRSLSGGQRQRLTLARSLVTDPEVLVLDEPTSAVDSHTEARVADGVRALRAGRTTVVFSSSPLLLDRADRVVFLREGTVAAVGAHEDLVRSNPVYRAVVTRQTDEEPDKELVESGKSEPIGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMZ1</accession>
    <name>A0A2G1XMZ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07335</name>
        <name evidence="3" type="ORF">CYQ11_27490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52573">
        <property type="protein sequence ID" value="PHQ52573"/>
        <property type="gene ID" value="BLA24_07335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16111">
        <property type="protein sequence ID" value="PPT16111"/>
        <property type="gene ID" value="CYQ11_27490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="510" mass="53341" checksum="230A667C0DA093E3" modified="2018-01-31" version="1">MSKGREAVLKRAFVAPDPGRLRLRTAARAVLGTGLAVAAAVLAGLPLPATILGGLAALLALFTVGDPTVRRQAVTTALLPAVGFPVLALATALHGRPLIRDAAFLAVVFCGVYARRWGARGQALGIFGFMMFFATQFLHAVPAQLPQLYAAEALALAACGLVRFGLWCVERRTPPPAVPAPPAARGLARPTTRQAFQNTFACALALGVGQMVSDERWYWAVGTAWWIFVNTASRGETLVRGFRRVVGTVAGIGVGLVVAVPLHGAPLPTIALVAVCVFGIFYTAAPSYSWMMFFVTVMAGLLYGLLGVLHPGLLALRLEQTLVGAAGAALAVALVLPVTTHAATDAWVQRALLAVRECTAVSARRLAGDEAADPAPHVAELELLLARVRTSLAPLLHPLSPLRTRGDRAREVLVHLDDCARQARGLAEVAADPDASHDARLTAACQRVETALHALVATGETPGAATAPDAAPHHHPGAERALAHLHDLEAALASLATPLRSGRRGVFAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNL8</accession>
    <name>A0A2G1XNL8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_04475</name>
        <name evidence="5" type="ORF">CYQ11_01735</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52837">
        <property type="protein sequence ID" value="PHQ52837"/>
        <property type="gene ID" value="BLA24_04475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11786">
        <property type="protein sequence ID" value="PPT11786"/>
        <property type="gene ID" value="CYQ11_01735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304959" evidence="3">
        <location>
            <begin position="29"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="192" mass="20033" checksum="B2FEEA8793D253AA" modified="2018-01-31" version="1">MRHRAALPAVTALTALALALTAAPAAHAHGDTLKVEVTGQVQGHVTTDVTWENDNDPVDENVAATVNAVSPDGDRTVGPWKLQRDPAKAGRYTTAETLPAGQWKVTVEVGFPALGRGEKELTVDPAAEPAPLSSPTAAGPPVPERKTSPEKPATRPQAEPGHEGGGWWIAAAGAALALLAGAGAFWWRRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNS7</accession>
    <name>A0A2G1XNS7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B/F/G family RNA polymerase sigma-70 factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_04810</name>
        <name evidence="8" type="ORF">CYQ11_28720</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52888">
        <property type="protein sequence ID" value="PHQ52888"/>
        <property type="gene ID" value="BLA24_04810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11453">
        <property type="protein sequence ID" value="PPT11453"/>
        <property type="gene ID" value="CYQ11_28720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="294" mass="33235" checksum="931376CF9C5D9A4E" modified="2018-01-31" version="1">MTSISAAKPATAEPSGTDKSEPLEGALPLLEDAGSVDPKDARALTKIFLDRLGALEEGTHEYQYVRNTLIEMNLSLVRFVAGRFRTRAEQMEDIVQVGTIGLIKAIDRFDLMREVEFTTFAIPYVTGEIKRFFRDTSWAVHVPRRLQELRVELAKATDELSGHLGRSPSVRELAEVMDLSEEEIIEAQIASNGYRANSLDMRAESAPHHQLSSRSWDERIGTVDENLEKVENLHVLKRLLPELDDRERRILGMRFGQEMTQSQIGAELGISQMHVSRLLSRTLGRLRTHMLAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW9</accession>
    <name>A0A2G1XNW9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04970</name>
        <name evidence="3" type="ORF">CYQ11_28560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52910">
        <property type="protein sequence ID" value="PHQ52910"/>
        <property type="gene ID" value="BLA24_04970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11429">
        <property type="protein sequence ID" value="PPT11429"/>
        <property type="gene ID" value="CYQ11_28560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="26728" checksum="886E112A333CC90E" modified="2018-01-31" version="1">MNDIRRPATADVPPEEPSARLRPRGLVDLRGRHDPPAVLLYPPGAVVVVSGLPGSGKSTLMRRWSACAATVDPRVVHEACQSVMPERLPYAVYRPWARLTYARWLRTEARGGAPLLVHDCGSRSWMRRWLARTAGRQGRELHLVLLDVGVAEALAGQAVRGRRAPGRVFAKHRRGLGRLLGTLSAAAGAPGDRLPGAVLPVPDAVAEAASVVLLDRTSREHVAAVEFGSGTGRAGPEPGVTQPSASGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNZ2</accession>
    <name>A0A2G1XNZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05120</name>
        <name evidence="4" type="ORF">CYQ11_28410</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52933">
        <property type="protein sequence ID" value="PHQ52933"/>
        <property type="gene ID" value="BLA24_05120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11406">
        <property type="protein sequence ID" value="PPT11406"/>
        <property type="gene ID" value="CYQ11_28410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="424"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="515" mass="55569" checksum="1070B38F2A0F5F56" modified="2018-01-31" version="1">MQATATTAFVHPVEDTLNAFAAFPEREVLVHQDRRITAGEFRALVHRLARALEGEGLGRGDGVTLLSGNLPEIIAARYAANLIGCRVNHLYGKLSAEAQAAIVHDVETRALIVDPRCADRAAEVTAATAVDKVLVLGPAKEGTDLLEAAAGYPDEPLPARGEPDDIWSIRHTGGTTGRPKGICMSFGQMSAFQRMGAEKPLSHERRQLVCTTIAHASGMFADSTLRGGGTVVLLDEFEPGAVLAAIERERITDVFLLPPLLYQLLDHPDAATTDTSSLRGLMYGGCQASPARIADAVRRFGPVLVQFYGQSEAGGISVLPADAHDLKHPERLRSAGTALPGVEVSIRDEAGRPLPTGERGEICVRSRSLMQGYWKQPELTAEVLRDGWLHTGDIGFLDDEGFLTVADRLKDMIIVVGGHVYTSELEDLLNSHPQVLQSAVFGVRDADSMERVHAVVVPRAGADVDERQLRALVRRERGEMYEPARITFAAALPLTETGKPDKKELRRAAEEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP10</accession>
    <name>A0A2G1XP10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dispase autolysis-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52985">
        <property type="protein sequence ID" value="PHQ52985"/>
        <property type="gene ID" value="BLA24_05150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="355" mass="36441" checksum="CF349EC3C7B52246" modified="2018-01-31" version="1">MLVQSPAAVAAAPAGWTVPSCDRVTGDGSVTFTSDDGASLAPTTGTLKPVSYTHGLVALDTPNTLLATRNSELQRSTDAGCTWTRVATLGSGITRLTAAPGGRAFAWEVNGGFLARVDGRKVTRLTSPAADIVGVGADRNRPGHVRLAGADGQLYDSTDAGASWRSVGTKAFGGGTNLYAVSFDPANIDHAVAGGMVNGGSVTTDGGATWTASTGLTTAGGTANLFQAAVSPADSSVVYALGIDLVEAAPSSGAEGRHLYRSADGGRTFAKVVDDTRDTELTNSTLLAPSPADANVLYFEYGTYFQAYGTDLYRLDASTGKVTKNHNAHDGISAIAFNPVQPKVMYLGLEEVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPI1</accession>
    <name>A0A2G1XPI1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02035</name>
        <name evidence="6" type="ORF">CYQ11_04395</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53148">
        <property type="protein sequence ID" value="PHQ53148"/>
        <property type="gene ID" value="BLA24_02035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12238">
        <property type="protein sequence ID" value="PPT12238"/>
        <property type="gene ID" value="CYQ11_04395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="27"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="28692" checksum="6573AA97C2EA9306" modified="2018-01-31" version="1">MPVNALTVVRAGALTTVQDLGRPGYAHLGVPRSGALDEPAHRLANRLVGNAARCATLETTVNGCALRTGAAVTFAVTGAPCPVRVDGRPGAWGAPVRAPAGAVVEVGPASAGLRSYLAFAGGVAVPPVLGSRSRDLLSGLGPEPLVDGASLPLGPVCGPPGAADAVPCAAPPTAELVLPLVPGPRDDWFTGDALRTLAGGGFRVSPASNRVGLRTEGPALRRAREGELPSEGVVLGAVQVPPDGRPVVFLADHPTTGGYPVVGVVPAPALAGAAQAVPGVAVRFVPVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPI4</accession>
    <name>A0A2G1XPI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000059">
        <property type="protein sequence ID" value="PHQ53059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53059">
        <property type="protein sequence ID" value="PHQ53059"/>
        <property type="gene ID" value="BLA24_03955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="57" mass="6456" checksum="4D806651AD669ED3" modified="2018-01-31" version="1" fragment="single">MTQSKDTDPYADPRAFYGSELKRLREGAGLTQEQLGQRVFCSASYIGQFETAVRRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPL1</accession>
    <name>A0A2G1XPL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02180</name>
        <name evidence="2" type="ORF">CYQ11_04545</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53172">
        <property type="protein sequence ID" value="PHQ53172"/>
        <property type="gene ID" value="BLA24_02180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12264">
        <property type="protein sequence ID" value="PPT12264"/>
        <property type="gene ID" value="CYQ11_04545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="109" mass="12033" checksum="1A8A0745B4A8F2B8" modified="2018-01-31" version="1">MAGQLWDLARVDLEPARAALARLHERGRPVGPCLLARAARATWWLLPLGTGYRLLGTGGVTLLPVGHELHVPPPTRYVRDRVWLVPARNGSFTHPEDLREALEAVASCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPM7</accession>
    <name>A0A2G1XPM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02215</name>
        <name evidence="4" type="ORF">CYQ11_04575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53176">
        <property type="protein sequence ID" value="PHQ53176"/>
        <property type="gene ID" value="BLA24_02215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12268">
        <property type="protein sequence ID" value="PPT12268"/>
        <property type="gene ID" value="CYQ11_04575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304768" evidence="1">
        <location>
            <begin position="29"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="61"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="353" mass="37101" checksum="667323B3B2ADB811" modified="2018-01-31" version="1">MRPRAWCGVLAAVALAATACGGGGTEKADDAGASAGSRAGFPVTVGDCTGAKTTFDSAPRRIVTSNAAGLELLMWLGAGDKVVGTGFPPGSGVLPGQYAESGAKVPVLGKTVIPKEKLLGSGADLYVDSFSSMKNMGKMGDAPTAEEFKAAGIKHVFLKSTACASMSKAPRTDLSGVEADVEEMGRITGTSQRAAELVAAMRKKTGEVRDALKDVPADKRPTYFLFDYDAGTKQPMAVCNRQVANAVITQAGGRNVFADCDGDFKPVGWEDVVAKNPDWIQLAVRNRGSEDADRKAFEEAEKFLREFPATAGLDAVKEGRFLRVASERTTIGGVRSADTVREIAHALHPDRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ05</accession>
    <name>A0A2G1XQ05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_03135</name>
        <name evidence="5" type="ORF">CYQ11_05435</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53312">
        <property type="protein sequence ID" value="PHQ53312"/>
        <property type="gene ID" value="BLA24_03135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12409">
        <property type="protein sequence ID" value="PPT12409"/>
        <property type="gene ID" value="CYQ11_05435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304767" evidence="2">
        <location>
            <begin position="36"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="55"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="388" mass="42667" checksum="E18CF2D62A4E9B94" modified="2018-01-31" version="1">MQQEQRPGRRTVLGAAAALGAGAVALGGGASPASAAPRGAEAHGDGGSYKNLPVPTVIGHRGACGYRPEHTFGSYEYALANGADVIEQDLVPTKDGHLVCRHENDITATTDVASRPEFASRKTTKTVDGEAHTGWFTEDFTLAELKTLRAKERIPGNRQHNTPYDGRWQVPTFEEVLKWADEQGRKRGRRIWLHVETKHPTYFRKAGLGLEERLAKLLRRYGRSGRNGYTFIQSFEPGSLQRLNKLGVDCPKVLLLDDLPTRPWDFVEAGDPRTVADLITPKGLAWVSGFAQGIGPWLNLIIPRDKDEKLTKPTTLVRDAHAAGLILHPYTMRNENSFLPADFRRGSDPNGYGDAFAAFKTYFATGIDGIFSDNCDTAALARADFVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ11</accession>
    <name>A0A2G1XQ11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03155</name>
        <name evidence="4" type="ORF">CYQ11_05455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53316">
        <property type="protein sequence ID" value="PHQ53316"/>
        <property type="gene ID" value="BLA24_03155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12413">
        <property type="protein sequence ID" value="PPT12413"/>
        <property type="gene ID" value="CYQ11_05455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="191" mass="21069" checksum="F44192D5680EAB5C" modified="2018-01-31" version="1">MSHSGYRRLMSLDRERVLTAAAALLTRKATASMDEIAKAAGISRATLHRHFAGRDALVRALEQLGIEQFERALDEARLEEGDAAEAVRRLIARAEPVAGLLSFLYSENQLFEGEMDEGWNRLDARVHALFARGQEQGAFRIDLSPAWLTDALYGLIASGAWAVHDGRVAAKDLTRMVSELLLGGALRRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ30</accession>
    <name>A0A2G1XQ30_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03075</name>
        <name evidence="3" type="ORF">CYQ11_05375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53301">
        <property type="protein sequence ID" value="PHQ53301"/>
        <property type="gene ID" value="BLA24_03075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12398">
        <property type="protein sequence ID" value="PPT12398"/>
        <property type="gene ID" value="CYQ11_05375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="29641" checksum="4206AA4980442A4B" modified="2018-01-31" version="1">MAELITIDDPGDPRLHDYTGLTDVELRRRREPAEGLFIAEGEKVIRRAHQAGYAMRSMLLTAKWVEVMRDVIDDADAPVYTVTPELAEQVTGYHVHRGALASMQRTPLPDAGELLRDARRVAVLESLVDHTNIGAIFRSAAALGMDAVLLSPDCADPLYRRSVKVSMGAVFSVPYARLESWPRDLETVREAGFRLLALTPDEKATSMDEAAPHRLERAALMLGAEGDGLSARALRAADDWVRIPMAHGVDSLNVGAAAAVAFYAVTTGRPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ36</accession>
    <name>A0A2G1XQ36_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000035">
        <property type="protein sequence ID" value="PHQ53346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53346">
        <property type="protein sequence ID" value="PHQ53346"/>
        <property type="gene ID" value="BLA24_01910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="71" mass="7366" checksum="9C61B3A63F1CE0AE" modified="2018-01-31" version="1">MDGVSTYLALTFGTLLSSQGTDASFVLTLSGFPPGASLRCSNLTRSVFRSVSGSHSVSGPLLERGFSRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQG5</accession>
    <name>A0A2G1XQG5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_00705</name>
        <name evidence="12" type="ORF">CYQ11_07715</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53485">
        <property type="protein sequence ID" value="PHQ53485"/>
        <property type="gene ID" value="BLA24_00705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12790">
        <property type="protein sequence ID" value="PPT12790"/>
        <property type="gene ID" value="CYQ11_07715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="389" mass="40722" checksum="0C3D457F5A5EA429" modified="2018-01-31" version="1">MPLSPEDVRNKQFTTVRLREGYDEDEVDAFLDEVEAELTRLLRENEDLRAKLAAATRAAAQNQQQNMRKPEPQDQRPGAPVPAAISGPQPVPPNQQQMGGPPQLPGGAPQLPAGPGGHGHGPQGPHGPGPMGQNGPMGGPMGGPMGQNGPMGQNPMQQNGPMGQNGMGQNGPMGGPQLPQPGQGPGGDSAARVLSLAQQTADQAIAEARSEANKIVGEARSRAEGLERDARAKADALERDAQEKHRVAMGSLESARATLERKVEDLRGFEREYRTRLKSYLESQLRQLENQADDSLAPPRTPAAASLPPAPSMSGSMASTGAGMGGHSMGGNQSMGGHGGPSTAAPSYGGQQQMSPAMTQPMAPVRPQGQQPMQAPSPMRGFLIDEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQG9</accession>
    <name>A0A2G1XQG9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ileS</name>
        <name evidence="11" type="ORF">BLA24_00700</name>
        <name evidence="12" type="ORF">CYQ11_07710</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53484">
        <property type="protein sequence ID" value="PHQ53484"/>
        <property type="gene ID" value="BLA24_00700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12789">
        <property type="protein sequence ID" value="PPT12789"/>
        <property type="gene ID" value="CYQ11_07710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="684"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="597"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116015" checksum="4EC602C55D5424F9" modified="2018-01-31" version="1">MTQYRQVPAQVDLPALEHAVLEFWREQKTFARTLEQSEGRPEWVFYEGPPTANGMPGAHHIEARVFKDVFPRFRTMQGYHVARKAGWDCHGLPVELAVEKELGFSGKQDIEAYGIAAFNDKCRESVTRHTDAFAELTTRMGYWTDLDGAYRTMDPDYVQSVWWSLKEIFTKGLLVQDHRVAPWCPRCGTGLSDHELAQGYETVVDPSVFVRFPLTSGPLAGEASLLVWTTTPWTLVSNTAAAAHPDVTYVVATDGNEKLVVAEPLLEKALGEGWTATGRSFTGREMERWAYRRPFDLVELEDASFVVNADYVTTEDGTGLVHQAPAFGEDDLRTCRAYGLPVINPVRPDGTFEEGLGLVGGQFFKKADEKLVADLSERGLLFKHVAYEHSYPHCWRCHTALLYYAQPSWYIRTTAVKDRLLEENEKTNWFPDSVKHGRFGDWLNNNIDWALSRNRYWGTPLPIWRCEENHLTCVGSLAELSELTGTDQSGLDPHRPYIDDVTFTCTADGCSHRAVRVPEVIDAWYDSGSMPFAQWGYPYKNKELFEQRYPAQFISEAIDQTRGWFYTLMAVGTLVFDKSSYENVVCLGHILAEDGRKMSKHLGNILQPIPLMDQHGADAVRWFMAAGGSPWAARRVGHGTIQEVVRKTLLTYWNTVAFQALYARTSGWAPGASDPAPAERPLLDRWLLGELNTLVGQVTEAMEAYDTQRAGKLLSAFVDDLSNWYVRRSRRRFWQGDAAALRTLHEVVETVTRLMAPLVPFITERVWQDLIVPVDPQAPESVHLATWPKADTALVDPALSQQMLLVRRLVELGRATRAESGVKTRQPLSRALVAAAGFEALGEELRAQIAEELNVSSLASLSEVGGSLVDTTAKANFRALGKRFGKGVQAVAKAVAAADAAALSLALREGTASVVVDGETVTLAPDEVIITETPREGWSVASDSGATVALDLEITPELRRAGLARDAIRLIQEARKNSGLDVADRIALRWTATDEETVTALTEHTGLIADEVLATDFATGEADDSYGEPFVDEGLGLTFRLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQU9</accession>
    <name>A0A2G1XQU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000003">
        <property type="protein sequence ID" value="PHQ53593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53593">
        <property type="protein sequence ID" value="PHQ53593"/>
        <property type="gene ID" value="BLA24_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="70" mass="7875" checksum="A8DBAB8C4B78D3A6" modified="2018-01-31" version="1">MPPAGWNRTQQSPSDVTYTSKDGAVELSAKQGRTTEDLLTHWQRFEEGFHGTPGTARSGWSARRTPETRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9H8</accession>
    <name>A0A2G1X9H8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside 2'-N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30715</name>
        <name evidence="3" type="ORF">CYQ11_23810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47882">
        <property type="protein sequence ID" value="PHQ47882"/>
        <property type="gene ID" value="BLA24_30715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15507">
        <property type="protein sequence ID" value="PPT15507"/>
        <property type="gene ID" value="CYQ11_23810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19360" checksum="29C62B7BA4B0EE35" modified="2018-01-31" version="1">MTELRTAHTSALTAAELAAVRALMDDAFEGDFTDEDWDHTLCGVHALVHDAGELIAHGSLVQRRLLHGGRALRTGYVEAVAVRADRRRQGHGSTVMAALERVLRDGGYQLGALGASDEAVPLYTGRGWRLWRGPASVLAPTGVERTAEEDGCIYVMPVPGVDVDLDGELTCDWRPGDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Q9</accession>
    <name>A0A2G1X9Q9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_31435</name>
        <name evidence="5" type="ORF">CYQ11_24480</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47974">
        <property type="protein sequence ID" value="PHQ47974"/>
        <property type="gene ID" value="BLA24_31435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15599">
        <property type="protein sequence ID" value="PPT15599"/>
        <property type="gene ID" value="CYQ11_24480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="570" mass="60295" checksum="377390B236F277BF" modified="2018-01-31" version="1">MCPHRRGKRSNRLRFPRIAPVGQAPHTSQGKSDMTVRRPRATWVTGFLLTAVTASTLTAAPAHALAGDTVNSSFGFTAKLDIGVGDDKRSCSAALVAPQWLVTAASCFVKDPTQGTKAPTGPLAPTLKTTATIGRTDLSKENGSVTDVVELVPRDDRDLVLAKLAKPITGVTPTAVSLNAPIEGQDLWLTGYGRTKTEWVPDRLHYATFTVGSVKSTTIGLTAKTEKAAVCQGDTGGPAFREVGGGYELVGINSRSWQGGCIGTDEKETRTGAIDTRVDDIAAWIREQVEPKAPEPRGDAPVDSNIDINGDGKADYLVLDDDGSVRAWANNSDDAKDDWISQGVIATGTGAPASKIRFADIDGDHRTDYLVVDDRGGIRAYINNSRVAKDSWIDRGVIATGTGTVASKIRFADINADGKADYLVVEDNGSVHAYVNNGGDTNGGWINRGVIATGTGAAGHKVRFADINADGKADYLVVEDNGSVHAWINKSSGTKDDWQDRGVIPTGTGAPGHKVRFADINADGKADYLVVEDNGSVHAWINKSSGTKDDWQDRGVIATGTGAPGHKVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9X7</accession>
    <name>A0A2G1X9X7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_31850</name>
        <name evidence="6" type="ORF">CYQ11_24905</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48047">
        <property type="protein sequence ID" value="PHQ48047"/>
        <property type="gene ID" value="BLA24_31850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15673">
        <property type="protein sequence ID" value="PPT15673"/>
        <property type="gene ID" value="CYQ11_24905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="322"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="499"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="558" mass="59566" checksum="0763F52CBEAC950F" modified="2018-01-31" version="1">MRLRALLETEALGLRLLGGEDELDRTVRGVMTTDLRDPSRYLSGGELVLTGLAWRREPEDSERFVRILTAAGVAGLAAGEAEIASTPDDLIEACARHRLPLFSVNEDVSFASVTEHVVRQVSSERAGDLAAVVDRHRRLMTGGPAGGGPEVVLDLLGSDLDLRAWVLSPTGRQIAGSSLADAGAALPAQVGAALAGEHLAASRSGRRGPHRVTAGGGTYSLFPVRSSGRAASARDVRETVLSDWLLAVEADAGEWPEERLDLLHGVTQLIAVERDRRDAARTVRRRLAQEVLELVQAGAAPAEIAARLRVAAPVLLPGLGTAPHWQVVVARVEWADGEIPGGPVAQSLLEEVLVDPDASGPEPSDRIAVAHTGDEAVALVPLPSVAAAPGESSAGLDADALLATVREPLTRGLADDGRVTFGVSAAVHSAEGLRGALEEARHARRVAAARPGPVCAAGHQELASHVLLLPFVPDDVRRAFTARLLDPLRDYDRRHRAELIPTLEAFLESDGSWTRCATRLHLHVNTLRYRVGRIEQLTGRDLSRLEDKLDFFLALRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA28</accession>
    <name>A0A2G1XA28_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32020</name>
        <name evidence="3" type="ORF">CYQ11_25075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48073">
        <property type="protein sequence ID" value="PHQ48073"/>
        <property type="gene ID" value="BLA24_32020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15699">
        <property type="protein sequence ID" value="PPT15699"/>
        <property type="gene ID" value="CYQ11_25075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="25686" checksum="50F3D632D9212F1C" modified="2018-01-31" version="1">MAKSVPVHCPTCRREHSFTPPTFPCACGAPLTVPVLPDADPELLAHRTWRDSWVAVRCPACDRQGQWPRPEFGCSCGAVVRLPVQPSCDVAPRGPDDDGSRRGAVTPPPFRPVAIRTERDAVMAAERYLRWLGFTGVRRPGSCPAPAASGVDLRAEGLVVRVDPTTLPTTLRDVECLWLHGLLESSDSACFSLAGYAGDARTRADDLRLPLFVLDLTGLPRALNDWADELVRRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA52</accession>
    <name>A0A2G1XA52_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32270</name>
        <name evidence="7" type="ORF">CYQ11_25325</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48114">
        <property type="protein sequence ID" value="PHQ48114"/>
        <property type="gene ID" value="BLA24_32270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15739">
        <property type="protein sequence ID" value="PPT15739"/>
        <property type="gene ID" value="CYQ11_25325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23591" checksum="7DA77AB638967885" modified="2018-01-31" version="1">MQHVILVVEDDHALRDVLLRGLRDEGFATVPAQNGAGALRLAGDSVDAVVLDVGLPDADGRDVCQAMRANGFLSPVIFLTAHHRLADRLGGFSAGGDDYLPKPFHLAELAARLRAALKRTGRPAPASTGDLVLDPVRHGLSVRGCEVALTPTEFRLLAALMASRGDVVSRRALVRAGWPEGAQVSDNTLDQYLSRLRRKLREAGSDLTVRTARGIGHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA68</accession>
    <name>A0A2G1XA68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32420</name>
        <name evidence="4" type="ORF">CYQ11_25470</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48137">
        <property type="protein sequence ID" value="PHQ48137"/>
        <property type="gene ID" value="BLA24_32420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15763">
        <property type="protein sequence ID" value="PPT15763"/>
        <property type="gene ID" value="CYQ11_25470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304804" evidence="1">
        <location>
            <begin position="34"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="314"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="530" mass="55815" checksum="F959F36B98A5B729" modified="2018-01-31" version="1">MRLTRQALRSTAAGAVCVALLAGGALGTPSAQAAPRAVAAGTAAADMVFTDIPGSGGITLKGNVLSPAHADGSRRYPLIVLPTSWAMPQIEYVAQARKLADAGYVVVSYTARGFWLSGGEIETAGPPDVADASKVIDWALAHTPADPGRIGMAGVSYGAGISLLAAGADRRVRAVVALSGWADLIESIYSGRTQHVQATGLLGGLGAVTGRPSPQMRRMLDEFLGPDVVAKEPELMAWGAGRSPATHLSDINAGGAAVMLGNAWGDSVFPPNQYVKFYENLTGPKRLELRPGDHATAEGTGLLGLPNDTWTNARRWFDHHLRGADNGIDREAPVQLKSRSDGGYEAYPDWASVERTRRTVPLTGSRTVRTGVDSGADGGVVLLSNTLDQFLKLPPLVSVPLLPRAYAAVWQSGPYDRPQRVRGTVRLHTTLTSDKESGTAVAYLYDVGPLGVGRLVSHAPYTFHGRTPGQSFGVDLDLFSTAYDVPAGHRLALVVDSVDPLYVQHNPVGARLTFSSPAADPSVLSVPVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAE1</accession>
    <name>A0A2G1XAE1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32785</name>
        <name evidence="5" type="ORF">CYQ11_25835</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48198">
        <property type="protein sequence ID" value="PHQ48198"/>
        <property type="gene ID" value="BLA24_32785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15824">
        <property type="protein sequence ID" value="PPT15824"/>
        <property type="gene ID" value="CYQ11_25835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758455" evidence="3">
        <location>
            <begin position="32"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="352" mass="36695" checksum="D09D1981F880A714" modified="2018-01-31" version="1">MARLRLPVDPYIAALLGTVLAATLLPVRGSAATVAEGASTGAVALLFFLYGARLSTREALAGLRHWRLHLTVLACTFAVFPLLGLAAHGLVPYVLTPQLHTGLLFLCLVPSTVQSSIAFTSLARGNVAAAICAGSFSSVVGILLTPLLASALLGGSTGGFSFDSLLSVVLRLLVPFLAGQLLRPHLGGLLKRRGSVLGLVDRGSILLVVYVAFSQGVVKGVWHQVTPWRLLALAAVEAVLLAVMLTLTMRGSQWLGFDREDRIAITFAGSKKSLAAGLPMGTVLFGAQASLALLPLMLFHQMQLMVGAVLAKRFGRKSDVPPADTDVPSVDTPAGRPSPAGTIRTADAADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAG6</accession>
    <name>A0A2G1XAG6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32900</name>
        <name evidence="6" type="ORF">CYQ11_25950</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48218">
        <property type="protein sequence ID" value="PHQ48218"/>
        <property type="gene ID" value="BLA24_32900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15845">
        <property type="protein sequence ID" value="PPT15845"/>
        <property type="gene ID" value="CYQ11_25950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="545" mass="58041" checksum="1F177F9C80D9A390" modified="2018-01-31" version="1">MSATLVAKDLAAGHGDRTLFSGLDLVVAPGDVIGLVGANGAGKSTLLRLLAGLATPDEGTLRLSPPTATVGHLPQEPERREGETVGAFLARRTGVAAAQAALDTATQALVDGAPGADDAYAVALERWLDLGGADLDERAEEVVDSLGLAVGLDRHMTGLSGGQAARAGLASLLLSRYDVFLLDEPTNDLDLDGLDRLEAFVTGLRAGTVLVSHDREFLSRTVGKVLELDLAQQQVNLYGGGYASYLEERETARRHARDAYEDYADTRAGLEARARTQRNWMDKGVRNARRKSTDNDKIGRKFRAESTEKQAAKARQTERLIERLDVVEEPRKEWQLRMEIAAAPRAGAVVATLRGARAQRGAFAFGPVDLQIDWADRVAITGANGSGKSTLLAALLGRLPLEAGSASLGPGVVVGEVDQARALFFGTETLLDAFGAVVPELAPADVRTLLAKFGLKADHVMRSAVTLSPGERTRAALALLQARGVNLLVLDEPTNHLDLPAIEQLESALASYDGTLLLVTHDRRMLDAVAVTRRIEVAAGRVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP7</accession>
    <name>A0A2G1XAP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_33330</name>
        <name evidence="4" type="ORF">CYQ11_26380</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48285">
        <property type="protein sequence ID" value="PHQ48285"/>
        <property type="gene ID" value="BLA24_33330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15916">
        <property type="protein sequence ID" value="PPT15916"/>
        <property type="gene ID" value="CYQ11_26380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="13"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="558" mass="59839" checksum="C3CCA565EC14295D" modified="2018-01-31" version="1">MNRSEAAGEGEHRTPVLVVGGSLVGLSTSLFLGRLGVPHTLVERHAGTSTHPRGRGNNVRTMELFRVAGIQRRIEEAASVLAANSGILQTPGLVGDAGEWLFREIDPGGGLARFSPARWCLCSQNDLEPVLLTCARELGGDLRYSTELMSFDQDPEGVTARVKSVETGEHTTIRADYLVAADGPRSPVRERLGIGHTGPGDLFHNVSITFVSRDLASVVGDRRFIICYLTNPEADGALLPVDNRERWVFHAPWHPERGETLEEFTDERCREHIRRAVGVADLHVEVTGRAPWHAAERIAERFAHGRVFLAGDSAHEMPPTGAFGSNTGIQDAHNLAWKLSAVLGGWAGPGLLDSYDAERRPVAEQTSVRASARSVEHSHPGYAPEPGAGGGPGGKKGILNVVLGHRYPHGAVQGADPTTPVVPDGLRLTGEPGSRAPHLWLNRAGTRVSTLDLYERSMVLLSSAGTHAGWHTAAAHVARELGMPLDSYRIGEGPDAELSPAGDEDWAQLYGVTADGAVLVRPDGFVAWRSEGAPENPASALRSALVAVLAREDVHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP9</accession>
    <accession>A0A346M2I3</accession>
    <name>A0A2G1XAP9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BcmR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">bcmT</name>
        <name evidence="9" type="ORF">BLA24_33505</name>
        <name evidence="10" type="ORF">CYQ11_26555</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <title>Biosynthesis of biocyclomycin.</title>
            <authorList>
                <person name="Meng S."/>
                <person name="Pan H.-X."/>
                <person name="Tang G.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MG018995">
        <property type="protein sequence ID" value="AXQ04971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48317">
        <property type="protein sequence ID" value="PHQ48317"/>
        <property type="gene ID" value="BLA24_33505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15949">
        <property type="protein sequence ID" value="PPT15949"/>
        <property type="gene ID" value="CYQ11_26555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="11"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AXQ04971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="473" mass="47267" checksum="49CE1B050F67DE2C" modified="2018-01-31" version="1">MLKGPPGQRRALAAVALGVFCIQLDAFALNLALPSIGHDLGASTGSLQWAVSAYLLSTGTLMLGAGRLSDLWGRRRLLVVGLALFGASSLACATAPSLPLLVGARVAQGAGASLIMPVGLALLTNVYPADQRGRATGWALGMGGVATACGPFVGGALTEAASWRVIFWINVPLAVAAAVWASRTPGSRDTAAAPAVDWRGLAFATAALAAVAVFVERGPVWGWTSPRDGLVLAAAAVLLVAFVRHEGRVADPLVNLGLFRNGPFVVLTVAGAVANAATVLFLFVVPLALQGSWGLTAFAAGVAFLAPAAMMAVAGPLAGRVTPGAAVNVMALLLALAGGMLCAAPAIGALPVHLATMTVCGGVLGLANALTLIATQAVIRPERAGEASGVTKTVITVAAGLGVALSGAVADPDGRPASSAAADHALTATGLAALAAGLLLGVWSAARARADRTGRTRPEAGRTRRAMARTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAV1</accession>
    <name>A0A2G1XAV1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31855</name>
        <name evidence="3" type="ORF">CYQ11_24910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48350">
        <property type="protein sequence ID" value="PHQ48350"/>
        <property type="gene ID" value="BLA24_31855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16776">
        <property type="protein sequence ID" value="PPT16776"/>
        <property type="gene ID" value="CYQ11_24910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="31432" checksum="5ADAF917D985D85A" modified="2018-01-31" version="1">MDFLRPASWEDALAAKAEHPAAVPIAGGTDVMVEINFDHRRPEHLLDLGRVAELHAWETDGRDVRLGAAVPYARVIEHLRRELPGLARAAHTVGSPQIRNRGSVGGNLGAASPAGDSHPALLAAGAEVEAESVRGTRLIPVEEFYTGVKRNALAPDELIRAVRIRKATGPQQFSKVGTRNAMVIAVCAFGIALHPGSRTVRTGIGSAAPTPLRARAAEEFLDAALEEAGLWESRRAVPAPVAAQFAELAAGACNPIDDVRGSAAYRRRAVGVMARRTLGWVWEEYTTGERSAPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAV5</accession>
    <name>A0A2G1XAV5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">lysA</name>
        <name evidence="7" type="ORF">BLA24_32005</name>
        <name evidence="8" type="ORF">CYQ11_25060</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48356">
        <property type="protein sequence ID" value="PHQ48356"/>
        <property type="gene ID" value="BLA24_32005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16782">
        <property type="protein sequence ID" value="PPT16782"/>
        <property type="gene ID" value="CYQ11_25060"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="52"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="305"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="441" mass="45893" checksum="DBF54F9BC0C1B6FB" modified="2018-01-31" version="1">MPVPAEEPTPAPAPVWPASARVLPSGDLAVGGVALAELADRFGTPSYVIDEDEVRARARAWRAALPDAGVAYAGKAFLCRALVRWIEEEGLGLDACSAGELELAALAGFPPERIVLHGNAKSPDDLRTALRLGVGRVVIDGTGEIARLAALVPPGARQRVMVRVVPGVAAGAHAAVRTGVEGQKFGLSVASGEAEEAVARVLGQPRLELVGLHCHLGSQIASTGPYIAAVRRLVPLLGRLRDRHGVIFPELGLGGGFAIAYREGDPALDPRGYAERVGGELESLCGRQGLPVPRLTVEPGRWITGPAGVALYRVLAVKSAGDRMFVAVDGGMSDNPRPALYGARYTVRLVGRAAGAPPRPVTVVGRHCEAGDVLAEDVPLPADVRPGDVLAVPASGAYQLSMASVYNLVGRPPVAAVSGGRARLLVRRETAADLRSRDVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB74</accession>
    <name>A0A2G1XB74_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29490</name>
        <name evidence="4" type="ORF">CYQ11_05985</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48494">
        <property type="protein sequence ID" value="PHQ48494"/>
        <property type="gene ID" value="BLA24_29490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12507">
        <property type="protein sequence ID" value="PPT12507"/>
        <property type="gene ID" value="CYQ11_05985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="207"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="447" mass="48383" checksum="DE9F40072E20A1D8" modified="2018-01-31" version="1">MSESKPAGTGTPGYAGNADQEVVDLCRDLIRIDTSNYGDHSGPGERVAAEYVAEKLAEVGLEPRIIESHKGRASTVARIEGADPSRPALLIHGHTDVVPANAADWTHHPFSGEIADGCVWGRGAVDMKDMDAMTLAVVRDRLRSGRKPPRDIVLAFLADEEAGGTYGARYLVDKHPDLFEGVTEAIGEVGGFSFTVNENLRLYLVETAEKGMHWMRLTVDGTAGHGSMTNKDNAITELCEAVARLGRHEFPVRVTKTVRSFLDELSDALGTPLDPEDMEATLVKLGGIAKMIGTTLRNTAAPTMLGAGYKVNVIPGQAVAHVDGRFLPGYEEEFLADLDRILGPRVKREDVHADKALETSFDGRLVEAMQSSLRAEDPIARAVPYMLSGGTDAKSFDDLGIRCFGFAPLQLPPELDFAGMFHGVDERVPVEGLKFGARVLDRFLDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBA6</accession>
    <name>A0A2G1XBA6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29600</name>
        <name evidence="4" type="ORF">CYQ11_05875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48513">
        <property type="protein sequence ID" value="PHQ48513"/>
        <property type="gene ID" value="BLA24_29600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12488">
        <property type="protein sequence ID" value="PPT12488"/>
        <property type="gene ID" value="CYQ11_05875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758465" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="40"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="145"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="346" mass="37912" checksum="E9E858E6595A83F2" modified="2018-01-31" version="1">MNRPKTRRRLTRKRVLLRIALALALLVLAPLVTAGSALRASYAGAPADDAVTRGRDAVWLGHAWVDGRHGPAELARLRERTAGTGIRDLYVHAGPLEHDGTLPPTAYRNAKWLIDSVHREFPGVRVQAWLGDKLVGRGQDGGLWLGSPAARSAVVESARQVLRAGFEGVHLDVEPVRTGDRHFLALLDSLRPAVRSQGGVLSVAAQQIDPLPSMHTASGMLGSPKWWTQSYFGKVARRVDQIAVMSYDTALPWENLYGGYVARQTALALQVTPEETDLLMGVPFYHTDNLGHQSRAETAAAAVRGSRLGLSREDRHRQRFGLALYVDFAATEADWRAYRAGWGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBA9</accession>
    <name>A0A2G1XBA9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29565</name>
        <name evidence="2" type="ORF">CYQ11_05910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48506">
        <property type="protein sequence ID" value="PHQ48506"/>
        <property type="gene ID" value="BLA24_29565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12495">
        <property type="protein sequence ID" value="PPT12495"/>
        <property type="gene ID" value="CYQ11_05910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="524" mass="56474" checksum="AC9F0CED7BBC240E" modified="2018-01-31" version="1">MEVDRRLGADDAFLSDPSGMDAVLARGRPFGDSGYLREQTQAAFTFRLEKMAAFLPVARPLLTALERAGEPARYRVLGDPLVRYALQQLLTRFVTGRRAALAFEVCEAVLAETAHRLTAGATSGPLRDGSPEARHVGDASRTPWIWGEGPRDDMCARAFRHVVAHEYGGAPCAPSAGDVVMLRKATRLLGEILPETSRSALGHAHVVGVTPGVGAWRGKSSSSQFRLAGAVFLNRRMFRNPWWVAEALLHECLHQKLYDFRHAHSLLARDARGTGGGTAGGLLDELRKVVALWNSPGLEAGNLWDAQRAVAAFHVYVHVALFSTLAERRAPELRAVYGPPDAPCAMTPSRTAFERAHYLGEGLRSVCWAELGPAGRRMVDWLSSVLGAVDPAPPPPGSSLHLLLDRYLAEARRIEKVPPAGALVQRLAALREAEVDSTRAVLTGLGAQEQLDVLGCVPAQPSAQDEGAAFAETRRLIADTLLRLAPDGYSLNSLCPAARVPPDEMVRQMVEASSRELAVAGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBE4</accession>
    <name>A0A2G1XBE4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pup</name>
        <name evidence="7" type="ORF">BLA24_29670</name>
        <name evidence="8" type="ORF">CYQ11_05805</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48525">
        <property type="protein sequence ID" value="PHQ48525"/>
        <property type="gene ID" value="BLA24_29670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12476">
        <property type="protein sequence ID" value="PPT12476"/>
        <property type="gene ID" value="CYQ11_05805"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="ARC ATPase binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="Deamidated glutamine" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="72" mass="8003" checksum="1E7F8EDD3B0E0F64" modified="2018-01-31" version="1">MATKDTGGGQQKATRSTEEVEEQAQDAQVSEDLKERQEKLSDDVDSVLDEIDDVLEENAEDFVRSFVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH6</accession>
    <name>A0A2G1XBH6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">BLA24_29885</name>
        <name evidence="16" type="ORF">CYQ11_05585</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48560">
        <property type="protein sequence ID" value="PHQ48560"/>
        <property type="gene ID" value="BLA24_29885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12438">
        <property type="protein sequence ID" value="PPT12438"/>
        <property type="gene ID" value="CYQ11_05585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="133"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ48560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT12438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="374" mass="41328" checksum="D11D626F6E74B06E" modified="2018-01-31" version="1">MSAPNKSYDPVEVEALKPEEIERMRDEALAAFAAAADLDALREAKAAHMGDRSPLALANREIGALPPQAKADAGKRVGMARGAVNKALAARQAELEAERDARVLVEEAVDVTLPYDRTPAGARHPLTTLCERIEDVFVAMGYEVAEGPEVEAEWFNFDALNFEPDHPARAMQDTFFVQGEDKKAAESGVVLRTHTSPVQVRSMLDREPPVYVVCPGRVYRTDELDATHTPVFHQVELLAIDEGLTMADLKGTIEHMVRSLFGEGLTTRLRPNYFPFTEPSAELDMECYVCRGESVGDPEKACRTCSSEGWIELGGCGMVNPRVLVAAGIDPEKYSGFAFGFGIERMLMFRHNVEDMRDMVEGDVRFTRPFGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBU7</accession>
    <name>A0A2G1XBU7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_28450</name>
        <name evidence="7" type="ORF">CYQ11_07020</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48649">
        <property type="protein sequence ID" value="PHQ48649"/>
        <property type="gene ID" value="BLA24_28450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12672">
        <property type="protein sequence ID" value="PPT12672"/>
        <property type="gene ID" value="CYQ11_07020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="34045" checksum="F22087AC5018C3A2" modified="2018-01-31" version="1">MRSVFPGDGPAGPPPSGGTPAVEVRGLVKRYGPKTAVNGLDLTVDTGTVTAVLGPNGAGKTTTVETCEGYRRPDAGTVRVLGLDPVADSAALRPRIGVMLQSGGVYAGARAEEMLRHTASLHAHPLDVDALVERLGLGDCGRTTYRRLSGGQQQRLSLAMAVVGRPELVFLDEPTAGLDPQARHATWNLVRELRADGVTVVLTTHYMDEAETLADDVAIVDAGKVIAQGSPEELCRGGAENTLRFTGRPGLDLVSLLKALPADSAAAEPAPGSYRVDGKVDPQLLATVTAWCAQHGVMPDRITVERHTLEDVFLELTGKELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC35</accession>
    <name>A0A2G1XC35_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YbhB/YbcL family Raf kinase inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28875</name>
        <name evidence="3" type="ORF">CYQ11_06590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48719">
        <property type="protein sequence ID" value="PHQ48719"/>
        <property type="gene ID" value="BLA24_28875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16385">
        <property type="protein sequence ID" value="PPT16385"/>
        <property type="gene ID" value="CYQ11_06590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19123" checksum="CE9D9299F3D5E2BD" modified="2018-01-31" version="1">MSEQKRRPLPHDFHPPVPSFTVASDDVTDGARLKSDQVHAGGNVSPHLRWEGFPEDAKSFAVTCFDPDAPTGSGFWHWVLFDIPAGVTELPAGAGSGGMKELPEGAVHVRNDYGTRDFGGAAPPPGDGPHRYVFTVYAVDREKLGPDADASPAVVGFHLRFHALARAQLIGEYEVPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC46</accession>
    <name>A0A2G1XC46_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27410</name>
        <name evidence="3" type="ORF">CYQ11_18235</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48802">
        <property type="protein sequence ID" value="PHQ48802"/>
        <property type="gene ID" value="BLA24_27410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14548">
        <property type="protein sequence ID" value="PPT14548"/>
        <property type="gene ID" value="CYQ11_18235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025644">
        <property type="entry name" value="DUF4344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14247">
        <property type="entry name" value="DUF4344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="366" mass="39053" checksum="FC7A5289EC7CD924" modified="2018-01-31" version="1">MRSPDLTSCSSSTTATRITARSLFPWSPEPPAASLTPPACRTGGAKRSLSLHPWQGPPPPTGGGRPGPTTDFRTSVPTGRVLSMLHHAGTGPRITARAWRARALVAAGVLAATVLATGCGPGSQAAASPTRGGLSVSYEAPEGGGAGERAARAFLTDRRLAEQVAQDVNASVRLPKGVEIVGRSCDKDDTPEYHPQTGRIALCYGFVGEVRRMFAADPSSGAGDPDERTAGVITETLYHEAAHALLDKLDLPFTGREEDVADQFAAYRLLRQGKKGRAALLAAADNYDQYARESGPDDFDPSDEHAPDSVRSVNYRCYLYGSAPDASRDMVGRQGLTEERAELCEEEYDALRRGWNTLLRPYATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB4</accession>
    <name>A0A2G1XCB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27645</name>
        <name evidence="3" type="ORF">CYQ11_17995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48841">
        <property type="protein sequence ID" value="PHQ48841"/>
        <property type="gene ID" value="BLA24_27645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14513">
        <property type="protein sequence ID" value="PPT14513"/>
        <property type="gene ID" value="CYQ11_17995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="324" mass="35022" checksum="348C9E5D46FCBB25" modified="2018-01-31" version="1">MDYTQLGRTGLKVSRIVLGTMNFGPGTDEGDSHAIMDAALDAGINFFDTANVYGWGENKGRTEEIIGSWFAKGGGRRDKVVVGTKVFGAMNPGGEPWPNEDRLSALNIRRSVEGSLKRLRTDHIDLYQFHHVDRSTPWDEIWQAIDVLVQQGKIVYAGSSNHAGWHIARANEAARRRGTLGLVSEQCLYNLAERRAEMEVIPAAEAYGLGVIPWSPLAGGLLGGAIRKAAAGGRSAEALANTTVREQVQAYEDLVAKYELEPGEVALAWLLTRPGVTGPIVGPRTSAQLDSAVRAGRLKLPEELLKALDEVFPGPGPAPEAFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB7</accession>
    <name>A0A2G1XCB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Flavodoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28010</name>
        <name evidence="3" type="ORF">CYQ11_17630</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48904">
        <property type="protein sequence ID" value="PHQ48904"/>
        <property type="gene ID" value="BLA24_28010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14447">
        <property type="protein sequence ID" value="PPT14447"/>
        <property type="gene ID" value="CYQ11_17630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="21412" checksum="9D05F9D179C1FFB0" modified="2018-01-31" version="1">MADAGAAQGLEGRSFLFLLGSARTDGNTETLARRAAEQLPAGVEQRWLRLSELPLPAFEDRRHGGGHGGEGPAGNERTLLDATLEATDLVVASPLYWYSVSAATKLYLDHWAGWLNARELHFRDRMRGKTMWAVTTTSHEDAAKADPLLGTLRLSADYMGMSWGGALVGHGNRPGDVEGDADVLRDAEALFRPAARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCE1</accession>
    <name>A0A2G1XCE1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27940</name>
        <name evidence="4" type="ORF">CYQ11_17700</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48892">
        <property type="protein sequence ID" value="PHQ48892"/>
        <property type="gene ID" value="BLA24_27940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14460">
        <property type="protein sequence ID" value="PPT14460"/>
        <property type="gene ID" value="CYQ11_17700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304775" evidence="2">
        <location>
            <begin position="31"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="26335" checksum="4B829D1FE327FA36" modified="2018-01-31" version="1">MPIAPRWAVLTAATTVIVLTAAGCSSDSGGDDKTDAKGTKAGQSAAPPPTGPAPGTPSGTASPGGPSGGTADGTIPAGPGPQPAYTVQQQPAPGTCAYRYTADKQPLPDPKCTPGATNPKVTQATLKTTICRGGYTAGIRPPTNITGREKTANAASYGYKGSLKDAEYDHLISLQLGGDPNDPRNLWVQPPSPGHKAGAGPNNPKDVVESKVKAAICAGKTDLVTAQRAIAKDWTTALSVLGVSTDKKAPKEEQKDEDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCH2</accession>
    <name>A0A2G1XCH2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27595</name>
        <name evidence="3" type="ORF">CYQ11_18045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48933">
        <property type="protein sequence ID" value="PHQ48933"/>
        <property type="gene ID" value="BLA24_27595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16636">
        <property type="protein sequence ID" value="PPT16636"/>
        <property type="gene ID" value="CYQ11_18045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="112" mass="12590" checksum="40197CADE4BA1DBD" modified="2018-01-31" version="1">MTTLNRPGAPGGHVCGIDTAMEVIGGKWKVLILWALHEHPHRRFGELRRLLPGVTEKVLASHLREMESDGVVHRFSYDEVPPRVEYSLTEDGTRLNAALEPLAAWGRERRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCP8</accession>
    <name>A0A2G1XCP8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">BLA24_23075</name>
        <name evidence="6" type="ORF">CYQ11_23000</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48990">
        <property type="protein sequence ID" value="PHQ48990"/>
        <property type="gene ID" value="BLA24_23075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15365">
        <property type="protein sequence ID" value="PPT15365"/>
        <property type="gene ID" value="CYQ11_23000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="40577" checksum="50946BE833B48948" modified="2018-01-31" version="1">MTAISLGMPSVPTKLADRRVSRKIQVGSVAVGGDAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIKQFDDKVKEIAKAASDAGTPIRIGVNAGSLDRRLLQKYGKATPEALVESALWEASLFEEHGFRDIKISVKHNDPVVMVNAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPAEEIKVGIQILESLNLRQRRLEIVSCPSCGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAEQMEKDGVASGEPTISVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCQ2</accession>
    <name>A0A2G1XCQ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4190 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_23145</name>
        <name evidence="5" type="ORF">CYQ11_22930</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49002">
        <property type="protein sequence ID" value="PHQ49002"/>
        <property type="gene ID" value="BLA24_23145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15353">
        <property type="protein sequence ID" value="PPT15353"/>
        <property type="gene ID" value="CYQ11_22930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="25526" checksum="36C493144FD969A5" modified="2018-01-31" version="1">MSDRDDAQPELLDGDTWAPPGTPVPLDKPAAPSLPPVPPVAPAVPAPPAGQPAPLPMPPVAPVPPARAGVPPVPPVPLAPTGPGTPSAYQGEAHGLTWPAPPAQAFGTGPYAQGPYGPTAYATGAYGYPGPSYGPGWPGMTPAPNNGFGVAALVLGIIGTVLSWTIVFGVICSVLAIVFGAIGRSKVSTGEGTNGGQALAGLILGGVGLLATACFLAFYITHDDGDDDPDYDGGDDTYGAYMAAPPGPAPLVFAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCS0</accession>
    <name>A0A2G1XCS0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_23140</name>
        <name evidence="5" type="ORF">CYQ11_22935</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49001">
        <property type="protein sequence ID" value="PHQ49001"/>
        <property type="gene ID" value="BLA24_23140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15354">
        <property type="protein sequence ID" value="PPT15354"/>
        <property type="gene ID" value="CYQ11_22935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="45"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="203" mass="21424" checksum="692175924019DA3F" modified="2018-01-31" version="1">MGSGASTADGPRSVAELTAAVAAGEQVGYVHFWGHRPRRDGSVGPGCFSQWWPSPFSVDGTVYATAEHWMMAGKARLFGDAEAEARVIAAGDPQQAKEAGRSVRGFDEEEWRRHRFGLVVEGSVHKFARHPELGACLLGTGSRVLVEASPLDRVWGIGLAAGDEAAADPARWRGLNLLGFALMEARQRLAAKTSGAGPGGAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCV3</accession>
    <name>A0A2G1XCV3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23410</name>
        <name evidence="3" type="ORF">CYQ11_22660</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49042">
        <property type="protein sequence ID" value="PHQ49042"/>
        <property type="gene ID" value="BLA24_23410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15312">
        <property type="protein sequence ID" value="PPT15312"/>
        <property type="gene ID" value="CYQ11_22660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="141" mass="15757" checksum="F50B5575F850612F" modified="2018-01-31" version="1">MTTNHGIGTETSGCGGDEQLPFDVFARNCPSRETLANVTGRWGSLTLGALHEDTLRFNELRRRVEGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYRLTALGREVTGRLMGLIALLEERMPEILAARGRYDTERGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCV8</accession>
    <name>A0A2G1XCV8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ORF">BLA24_23300</name>
        <name evidence="9" type="ORF">CYQ11_22775</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49025">
        <property type="protein sequence ID" value="PHQ49025"/>
        <property type="gene ID" value="BLA24_23300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15329">
        <property type="protein sequence ID" value="PPT15329"/>
        <property type="gene ID" value="CYQ11_22775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="116" mass="13152" checksum="C1A72226DC88AF33" modified="2018-01-31" version="1">MSSLLDNVNAASLRTDVPAFRPGDTVNVHVRVIEGNRSRIQQFKGVVIRRQGAGISETFTVRKVSFSVGVERTFPVHSPIFEKVELITRGDVRRAKLYYLRELRGKAAKIKEKRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD14</accession>
    <name>A0A2G1XD14_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_23965</name>
        <name evidence="11" type="ORF">CYQ11_22105</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49133">
        <property type="protein sequence ID" value="PHQ49133"/>
        <property type="gene ID" value="BLA24_23965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15218">
        <property type="protein sequence ID" value="PPT15218"/>
        <property type="gene ID" value="CYQ11_22105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304581" evidence="8">
        <location>
            <begin position="34"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="9">
        <location>
            <begin position="638"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="758" mass="78604" checksum="A3BA3DBE61ED457D" modified="2018-01-31" version="1">MRPTPHHRAVAGGALVAVTALIAVGMQSGAASARTDDAKAAPGTLVAKADPGAMPAKLSPSQRAELIREANATKAETAKTLGLGTSEQLVVKDVVKDVNGTVHTRYERTYEGLPVLGGDLVVDATKGGQVKTVAKANKARLAVATSAPSFAAATAERDAVKAAQAKGSQATKAERAPRKVVWAAQGTPVLAYETVVGGLQEDGTPNELHVITDAKTGQKLFEFQGVKQGTGNSQYSGTVTIGTTPSYTMTDGTRGGHKTYNLNHGSSGTGTLFTDSDDVWGNGTNSDPATAGVDAHYGAQLTWDYYKNVHGRTGIKGDGKGAYSRVHYGNSYVNAFWSDDCFCMTYGDGSNNAKPLTSIDVAAHEMTHGVTSATANLTYSGESGGLNEATSDIFAAAVEFWANNPTDLGDYLVGEKIDINGNGTPLRYMDKPSKDGRSKDAWYSGLGGIDVHYSSGPANHWFYLASEGSGQKEINGVKYDSPTSDGLPVTGIGRDNAAKVWFKALSQRMQSNTNYAGARDATLWAAGELFGVGSETYNNVANAWAGIGVGSRASTGVSVTSPGDQTSIVNTAVSLQIKASSSTTGSLTYSATGLPAGLSINSSTGLISGTPTATGTSTVTVTVKDSSGKTGTATFKWTVNTTGGGSVFENTTPVAIPDAGAAVTSPVVVTRSGNGSSALKVDVNITHTYRGDLQIDLVAPSGKTWRLKDSDSWDSAEDVKESYTVDASAESATGTWKLKVQDLYSADSGTINSWKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD66</accession>
    <name>A0A2G1XD66_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pyk</name>
        <name evidence="17" type="ORF">BLA24_24185</name>
        <name evidence="18" type="ORF">CYQ11_21890</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49168">
        <property type="protein sequence ID" value="PHQ49168"/>
        <property type="gene ID" value="BLA24_24185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15182">
        <property type="protein sequence ID" value="PPT15182"/>
        <property type="gene ID" value="CYQ11_21890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ49168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT15182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="51277" checksum="35F560DAE43B87FE" modified="2018-01-31" version="1">MRRSKIVCTLGPAVDSFDQLKTLIEAGMNVARFNMSHGTHSEHEERYHRLRKASEETGRAVGVLADLQGPKIRLETFADGPVELVRGDEFVITTEDVPGDKTICGTTYKGLPGDVVKGDQVLINDGNVELRVTEVDGARVKTIVIEGGVISDHKGINLPGAAVNVPALSEKDIEDLKFALAMGCDMVALSFVRDAADVRDVHRVMDEVGRRVPVIAKVEKPQAVENMAEVVMAFDGVMVARGDLAVEYPLERVPLVQKRLIEMCRRNAKPVIVATQMMESMITNSRPTRAEASDVANAILDGADAVMLSAESSVGAYPIETVKTMSRIVEAAEQELLSKGLQPLVPGKKPRTQGGSVARAACEIADFLGAKSLVAFTKSGDTARRLSRYRAAQPILAFTTDASTRNQLTLSWGVETYVVPHVDNTDAMVDLVDAELLKLQRYNAGDTMIITAGSPPGVPGTTNMVRVHHLGGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF1</accession>
    <name>A0A2G1XDF1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24670</name>
        <name evidence="3" type="ORF">CYQ11_21400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49258">
        <property type="protein sequence ID" value="PHQ49258"/>
        <property type="gene ID" value="BLA24_24670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15090">
        <property type="protein sequence ID" value="PPT15090"/>
        <property type="gene ID" value="CYQ11_21400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="161"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="290" mass="29552" checksum="817784F92ADF0FF8" modified="2018-01-31" version="1">MPDQSEWSLATPQKLTFDAPVTDLSVRIVGGTVNVVGTDSGPARLELTRIDGPPLLVSHKAGVLTVGYEDVPWQNFLKWFDRKGWKRTASATLTVPTATRVEVGVVSATAVVSGIGGATEVRGVTGDTTLVGVTGAVRAETVSGGLEAQALGGDLRFGSVSGDLTLIESSGGTVKADSVSGDMTLDLAALPPSDASRPAVALSSVSGEIAVRLPHSADTEVHANTTSGKVSCAVEGLRVEDQWGARRITGTLGSGQGLLKITTVSGAVALLRRPPVQDAPAGAPAQGKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDS4</accession>
    <name>A0A2G1XDS4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyldiaminopimelate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dapC</name>
        <name evidence="2" type="ORF">BLA24_25415</name>
        <name evidence="3" type="ORF">CYQ11_20660</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49387">
        <property type="protein sequence ID" value="PHQ49387"/>
        <property type="gene ID" value="BLA24_25415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14963">
        <property type="protein sequence ID" value="PPT14963"/>
        <property type="gene ID" value="CYQ11_20660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="39060" checksum="04562CBC0AFFA596" modified="2018-01-31" version="1">MSAVSSRLPVFPWDRLEPYKATAAAHPDGIVDLSVGTPVDPVPAVIQRALADAADSPGYPTVWGTAALRDALTGWAGARLGARDLEHVNVLPVVGSKELVAWLPTQLGLGAGDKVAYPRLAYPTYEVGARLAGAEPVVYDDPTELDPAGLRLLWLNSPSNPTGRVLSKEELRRAVAWARSHGILVVSDECYLELGWEAEPVSVLHPDVCGGSYEGLVAVHSLSKRSNLAGYRSAFLAGDAAVLGELLQIRKHGGMMIPAPVQAATVAALGDTAHVAEQRARYARRRAALRTAFEGAGFRIEHSEASLYLWATRDEPCWDTVGDLSKRGILVAPGDFYGEAGGRFVRIAFTATDERVEAAVRRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDZ8</accession>
    <name>A0A2G1XDZ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25680</name>
        <name evidence="3" type="ORF">CYQ11_20390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49435">
        <property type="protein sequence ID" value="PHQ49435"/>
        <property type="gene ID" value="BLA24_25680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14915">
        <property type="protein sequence ID" value="PPT14915"/>
        <property type="gene ID" value="CYQ11_20390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="27128" checksum="8A7B45C64CED2545" modified="2018-01-31" version="1">MAFGDQPAYLRVAGDLRQKIVAGELPPHTRLPSQARIREQYGVSDTVALEARKVLMAEGLVEGRSGSGTYVREQPVPRALVRTGYRAAGESTPFRQEQADDRVKGTWESRSEQGVADAAVARRLRIAPGDRVMRTDYLFRSQGEPCMLSTSWEPLALTGRTPVMLPEEGPLAGRGVVERMAAIDLIVDNVTEEVGARPGLAEETLALGGVPGHCVLVVSRTYFAGGCPVETADVITLAERHRVAYHLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE93</accession>
    <name>A0A2G1XE93_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_26335</name>
        <name evidence="6" type="ORF">CYQ11_19305</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49548">
        <property type="protein sequence ID" value="PHQ49548"/>
        <property type="gene ID" value="BLA24_26335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14731">
        <property type="protein sequence ID" value="PPT14731"/>
        <property type="gene ID" value="CYQ11_19305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="571" mass="58235" checksum="338500B5C4B88BDE" modified="2018-01-31" version="1">MTIRILPAVGEPETARAIGGLLAQLPGVEPLQTVGDSARLLDTLAVLAASSVGDLPEVVLVHERVGPVPALELVREVALRFPATGVVLVTADAGPALYAAAMDSGARGIAVLPLSYEELGTRVQAAAHWATGVRRHLGAAGDGLPAGGGHGGTLVAVVGAKGGVGTTVTAVQLALAAQAAGRSVALADLDLQSGDVASYLDVRFRRSIADLAGISDISPRVLQDAVFPHPTGLGLLLAPAEGERGEEIGDLAARQITAALRGRYEVVIADCGTQVTAAGAAVIETADVALLVTTPDVVSVRAAKRMVRLWERLQIRKAEETTTVVNRHTRGAEIQPALVARATGTTAARTTVPAGYKDLQGAVDAGRMQDLDARSGVRQALWALAAEIGLGTPGGRAPAQGGDRGGPSADRPAGTGLHRRRAIGAAPPPPGGGTGPDQLAPVPSGSPAPLGRFRRRGGRFGDRGQVAVEFVGVLPLILVALAVVWQCVLVGYTYSLAGHAADKGARAGAVGRDCVAAAVSDLPAAWRSEPDCGPDGGVYRASVRVRVPVLFPGSVNWPWTVESTAGVARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE2</accession>
    <name>A0A2G1XEE2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4034 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26465</name>
        <name evidence="3" type="ORF">CYQ11_19175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49571">
        <property type="protein sequence ID" value="PHQ49571"/>
        <property type="gene ID" value="BLA24_26465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14710">
        <property type="protein sequence ID" value="PPT14710"/>
        <property type="gene ID" value="CYQ11_19175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025115">
        <property type="entry name" value="DUF4034"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13226">
        <property type="entry name" value="DUF4034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4034" evidence="1">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="346" mass="38188" checksum="88FCDE2F7ECC440D" modified="2018-01-31" version="1">MLLSLLLVIAVPAFFWIRQKRRAAQSAAQLAAEGWLPPERQNTERSFPDPEADAVVAALARGDWQPAAQALAATGTDWERRSALVGIVAGEAAKDDAWLRAWEAARPGDPAAAVVKASAKVTVAWDIRGAAWAKDTTAEQFAGFHRMLAEAREDFDRAVSLAAPEDPTPYAAQIALYKGLGAPHEEMRKLWAEVTARAPYHFGAHRSALLYWYPRWHGSDELVREFAWGAARTAPPGHLMTLLPLLHWHDHLDDDAPDVAYRSVDLTIMVDAALMDVAACRPDHPRLAEARHFLAFILTTQERYAEAVEQFRRVDGHVGAEPWAYAPEPAEAFCQVRDAAIAGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE5</accession>
    <name>A0A2G1XEE5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26710</name>
        <name evidence="3" type="ORF">CYQ11_18925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49614">
        <property type="protein sequence ID" value="PHQ49614"/>
        <property type="gene ID" value="BLA24_26710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14666">
        <property type="protein sequence ID" value="PPT14666"/>
        <property type="gene ID" value="CYQ11_18925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="8558" checksum="B098A37CBAFCE976" modified="2018-01-31" version="1">MPQLVWRKSSYSVGQDGDCVEVAPHPGGLIRVRESDDPDFILTASPAAFAGLLRDLKRDIKAKTAPAAHHEAPRRAAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEG8</accession>
    <name>A0A2G1XEG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26450</name>
        <name evidence="5" type="ORF">CYQ11_19190</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49569">
        <property type="protein sequence ID" value="PHQ49569"/>
        <property type="gene ID" value="BLA24_26450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14712">
        <property type="protein sequence ID" value="PPT14712"/>
        <property type="gene ID" value="CYQ11_19190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="381" mass="39909" checksum="DEAEBDEB7FA1995A" modified="2018-01-31" version="1">MSDQHSFETLAIHAGQDPDPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALEGGARGLAFASGLAAEDCLLRTLLAPGDHVVIPNDAYGGTFRLFAKVVARWGVEWSVADTSDPAAVRAAIRPQTKAIWVETPSNPLLGITDIAALAGIAHEAGVKLVVDNTFASPYLQQPLALGADVVVHSTTKYMGGHSDVVGGALVTADAGLAEELAFHQNAMGAIAGPFDSWLTLRGIKTLAVRMDRHSANAERIAELLVAHPKVTQVFYPGLPGHALHEVAAKQMRAFGGMVSFRVEGGEEAAVELCNRTELFTLGESLGGVESLIEHPGRMTHASVAGSALEVPADLVRLSVGIESADDLIADLTQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEH8</accession>
    <name>A0A2G1XEH8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26855</name>
        <name evidence="4" type="ORF">CYQ11_18780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49638">
        <property type="protein sequence ID" value="PHQ49638"/>
        <property type="gene ID" value="BLA24_26855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14641">
        <property type="protein sequence ID" value="PPT14641"/>
        <property type="gene ID" value="CYQ11_18780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="373" mass="39814" checksum="706468D04AFD41A4" modified="2018-01-31" version="1">MQKTIAIVGAGLGGLTLARVLQAHGVSATIYEGEASATTRTQGGLLDIHEETGQVAVRAAGLYDEFLTLVRPGEDAKRVVDRHGTILFDMPADPGSARPEVDRGELRRLLIDSLAPGTIRWGHKLASVRHRVEGGYVLTFAEGSATRADIVIGADGAWSKVRPLLTPAKPVFSGTCFIEIALASGSQECRASVAAIGSGTLMAVAPGKGIIAHRYADGHVRGYVALNKPEEWMRSIDFGDPSAGLRHLADEFDGWSPLLTAFVTQSDVEPWLRPIYALPVGLKWDRVPGVTLVGDAAHLMSPFAGEGANLAMYDGADLASKLVEQPDIEVALTAYEERLFPRSGDAASRSAQNLEMFFGQEAPQSVVTLFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEJ0</accession>
    <name>A0A2G1XEJ0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_26900</name>
        <name evidence="8" type="ORF">CYQ11_18735</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49646">
        <property type="protein sequence ID" value="PHQ49646"/>
        <property type="gene ID" value="BLA24_26900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14632">
        <property type="protein sequence ID" value="PPT14632"/>
        <property type="gene ID" value="CYQ11_18735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="195"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="718" mass="77977" checksum="E9ACDFC05E93541C" modified="2018-01-31" version="1">MNPLTTSAFDLPATLSAKADPTLIDGDEQHFAAIAECLEQSIADLTDRLDALLRAPGGLGQQAMERDTEIHRLTGRLRALRRFGLDLCLGHMVGADHPEPVYVGRLGLKDSAGRRLLLDWRSPAAEPFFGATHANPMGLASRRRYRWTRGRISDYWDEVFTADGFAGHAALDDQSAFIASLGGNRSPRMRDVLGTIQADQDAIIRAGSRGALVVDGGPGTGKTVVALHRSAYLLYSDPRLAQRRGGVLFVGPHQPYLSYVADVLPSLGEEGVQTCTLRDLVAEGAAATVETDPDVARLKSSAGMVKAIEKAVGIYEEPPTEAMTVTTPWSEIRLGADDWAEAFDAAAGTPHNEAREQIWEELVAILLDRCEAEDVSPEQFRRSLRHDKELVGTLNRAWPLLEATDLVGDLWSVPAYLRLCAPWLSPDEVRKLQRKDAPDAWTVSDLPLLDAARQRLGDPEAARRKVRHKAAVAAERARMATVIDNVIASDDDGEGAVTMLRGRDLQDALVDEAALPGAAPDRLAGPFAHVVVDEAQELTDAEWQMLLLRCPSRSFTIVGDRAQARHGFTESWQERLERVGIDRIDLAALSVNYRTPEEIMAEAEPVIRAALPDANVPTSIRSGGVPVVHGSTAELSSVLDTWLAAHDEGTACVIGDPTFRPTSRVRSLTPELSKGLEFDLVVLVDPEAFGDGVEGAVDRYVAMTRATRQLVILTSAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEK8</accession>
    <name>A0A2G1XEK8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">BLA24_27010</name>
        <name evidence="8" type="ORF">CYQ11_18620</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49663">
        <property type="protein sequence ID" value="PHQ49663"/>
        <property type="gene ID" value="BLA24_27010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14613">
        <property type="protein sequence ID" value="PPT14613"/>
        <property type="gene ID" value="CYQ11_18620"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="404" mass="43080" checksum="81E965F391B90CC0" modified="2018-01-31" version="1">MTATERNIAAADQHSAHNYHPLPVVVATAEGAWMTDVEGRRYLDMLAGYSALNFGHGNRRLINAAKEQLERVTLTSRAFHHDRFGEFCSALAQLCDMEMVLAMNTGAEAVETAVKTARKWGYRVKGVPDGRAKIVVAAGNFHGRTTTIISFSTDPEARADFGPYTPGFEIVPYGDLAAMEAAVDDDTVAVLLEPIQGEAGVLVPPAGYLPGVRRLTRERGVLFIADEIQSGLGRTGRTFACEHEGVVPDVYVLGKALGGGVVPVSAVVSSREVLGVYRPGEHGSTFGGNPLACAVALEVVAMLRTGEYQERAARLGEHLHHELGLMTGSGAVTAVRGRGLWAGVDIAPEVGTGREISERLMARGVLVKDTHGSTIRIAPPLVITKEDLNWGLEQLRAVLGDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEK9</accession>
    <name>A0A2G1XEK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26980</name>
        <name evidence="2" type="ORF">CYQ11_18655</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49660">
        <property type="protein sequence ID" value="PHQ49660"/>
        <property type="gene ID" value="BLA24_26980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14618">
        <property type="protein sequence ID" value="PPT14618"/>
        <property type="gene ID" value="CYQ11_18655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="8221" checksum="08FB4FB844AD0D6A" modified="2018-01-31" version="1">MELQPWRLPASPGEPPYYTTDTCAGCGAVVHGIHGRWTCAACGACSPYQEPPEGWATEITPEELATNTVGYDSLPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL3</accession>
    <name>A0A2G1XEL3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26895</name>
        <name evidence="3" type="ORF">CYQ11_18740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49645">
        <property type="protein sequence ID" value="PHQ49645"/>
        <property type="gene ID" value="BLA24_26895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14633">
        <property type="protein sequence ID" value="PPT14633"/>
        <property type="gene ID" value="CYQ11_18740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="1">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="407" mass="42579" checksum="9FCE19749954995C" modified="2018-01-31" version="1">MRVLLLAYGSRGDVEPMVGLATQLRAVGAEVQVCAPPDFAELLDGAGLPLVPLGQSVREMATKAVTGTQPMPAKSLPQRAAEMFAATYASVAAVAEGCDAVVATGLLPAAAAARAVAEKLGVPYVFVAYFPTYLPSPHHPPLVWPGRPVPPEVTDNRVLWDLNADTMNELFGEAINTHRATIGLPPVGDVRDHVFTDRPWLAADPALSPWLETADLDVVQTGAWIRPDERPLPAGLEAFLDAGPPPVYVGFGSMPLRDAQDVTRAAVEAVRAQGRRVLLSRGWADLALTDDQDDCFAVGEVNQQALFGRVAAVVHHGGAGTTTTAARAGTPQVVVPQMADQPYWAGRVADLGIGAAHDGPAPTFESLSAALKTALTPETRARAQAVAGTIRTDGAAVATKLLLDAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEP7</accession>
    <name>A0A2G1XEP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26915</name>
        <name evidence="5" type="ORF">CYQ11_18720</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49649">
        <property type="protein sequence ID" value="PHQ49649"/>
        <property type="gene ID" value="BLA24_26915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14629">
        <property type="protein sequence ID" value="PPT14629"/>
        <property type="gene ID" value="CYQ11_18720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="9"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="531" mass="58059" checksum="FA5706368FC4C3E6" modified="2018-01-31" version="1">MTRPTPRSTESGLPVDPVLGPEALAGWNPAEKLGAPGSYPFTRGVYPTMYTGRPWTMRQYAGFGTAAESNARYRQLIEHGTHGLSVAFDLPTQMGHDSDADLASGEVGRVGVAVDSVEDMKVLFDGIPLGEVSTSMTINAPAALLLLLYQLVAEEQGVAAEHLTGTIQNDVLKEYVARGTYIFPPKPSLRLTADIFQYCRREVPRWNTISISGYHMAEAGASPVQEIAFTLANGIEYVRTAVAAGMDVDDFAPRLSFFFVSRTTLLEEVAKFRAARRIWARVMKEDFGARNPKSQMLRFHTQTAGVQLTAQQPEVNLARVTVQGLAAVLGGTQSLHTNSFDEAIALPTAKAARLALRTQQVLAYETDVTATVDPFAGSYVMESLTDDVEAAVLELMDEVEGRGGAVAAIEQGFQKAEIERNAYRIARETEAGERVVVGVNRFRIEEEEPYEPLRVDPTIEARQRERLERLRAERDRAAVESALTALRKAAAGTTENVLAPMKEALRARATVGEVCEALREVWGSHVPTEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEU5</accession>
    <name>A0A2G1XEU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26205</name>
        <name evidence="4" type="ORF">CYQ11_19435</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49746">
        <property type="protein sequence ID" value="PHQ49746"/>
        <property type="gene ID" value="BLA24_26205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16674">
        <property type="protein sequence ID" value="PPT16674"/>
        <property type="gene ID" value="CYQ11_19435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="738"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="775" mass="82074" checksum="ADC3CC5AEC195722" modified="2018-01-31" version="1">MGVRFTVTGGREAWFRTALTALGVGLGVALLMIAASVPQMMAQRQHREAARAPHVAEEGDEPVGRGPGTLILQRADTDFHDKPVAGVLLRPEGPKAPVPPGLREIPAPGEMVVSPALGRLLASADGAVLRERFPHRIVGTIGSSGLIGPSELSYYAGDDRITLDGPHGPGIHDTPARVDAFGTAEEKEPISPVLLVLAIMTCVVLLLPVAVFMATAVRFGGERRDRRLAALRLVGADARTTRRIAAGEALAGAVLGLGAGVTLFLLLREFAADVTIRDSSVFPSDMVPRPALVALIAVTVPAMAVVVTLFALRGVTIEPLGVMRDTGPRRRRLWWRLLFPVAGVALLFPLFGRASMDPWGDPLNTSQVAGGAVLLLVGITLLLPWVLQVLVDRLRGGAPAWQLAYRRLQLGSGPAARAVSGVTVAVAGAIAVQMLFAGVRGGYELPGDEASHSSMSGVFRAASAAETHDYAERFRATRGVVNAAVVVEEYATRDGRADRTTAISVGDCAELRRIARLDSCRDGDVFVADSPGGIRESDHFPPGSKLTMSEYLDPGSTREPRTYRWTVPDSARIVRTLPGPGEEFRGGVLATPSAIDTAAMPTASTRVRVQARPDDPDALERIRNTAAAIDPALRVWRDGGVVKDANYAMIERGLLIGTVGTLGLIGAGILVSTLEQLRERRRTLSALAAFGTPRSTLGWSVLWQTAIPVVLGMVLATGGGISLGWVMLQVVDGTVRDWFAFLPVTGAGAGVIALVTLASLPPLWRMTRPDGLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEX6</accession>
    <name>A0A2G1XEX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_19220</name>
        <name evidence="7" type="ORF">CYQ11_11580</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49783">
        <property type="protein sequence ID" value="PHQ49783"/>
        <property type="gene ID" value="BLA24_19220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13441">
        <property type="protein sequence ID" value="PPT13441"/>
        <property type="gene ID" value="CYQ11_11580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="27479" checksum="7ECD66DFCC6C2395" modified="2018-01-31" version="1">MAERFGPVLVPGDDDDEGARCADRGGGTTREEPIRVLVVDDHALFRRGLEIVLAQEEDILVVGEAGDGAEAVDKAADLLPDIVLMDVRMPKRGGIEACTSIKEVAPSAKIIMLTISDEEADLYDAIKAGATGYLLKEISTDEVATAIRAVADGQSQISPSMASKLLTEFKSMIQRTDERRLVPAPRLTDRELEVLKLVATGMNNRDIAKELFISENTVKNHVRNILEKLQLHSRMEAVVYAMREKILEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF35</accession>
    <name>A0A2G1XF35_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative sulfate exporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_19575</name>
        <name evidence="10" type="ORF">CYQ11_11220</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49843">
        <property type="protein sequence ID" value="PHQ49843"/>
        <property type="gene ID" value="BLA24_19575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13381">
        <property type="protein sequence ID" value="PPT13381"/>
        <property type="gene ID" value="CYQ11_11220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="391" mass="39231" checksum="158BFAE606619CCC" modified="2018-01-31" version="1">MALLGSHTKNSHTKNSRTKGSRPDEARTGGRPPGAGAPSATGPSAADRPRQPAGKSTRNLPGLAFAAVGVALAWAVHRLVPAVPMLTAAVVLGIAAAHVPGIRARVRGAGKPGLTLAGKRLMRVGIVLLGLKLSLDDVLGLGWATAAMVVAVVVATFFGTLWLGRRLGLRGDQPLLIATGYSICGASAIGAVSEVSGSDEEDVATSVALVTLCGTLAIAVLPLLHHPLGLDDAQFGRWAGASVHDVGQVVATAQTAGSAALGDAVLVKLMRVALLAPLVAAVAVSARHRRRSGGQAAGASGTSGKRPPLVPLFVVGFLAAVALRTTGWVPGSCLEAAQHAQELLLAAALFGLGSAVHLPSLVRTGGRVAALGLCSWVVVAGVSYGGVLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFH1</accession>
    <name>A0A2G1XFH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20460</name>
        <name evidence="2" type="ORF">CYQ11_10325</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49990">
        <property type="protein sequence ID" value="PHQ49990"/>
        <property type="gene ID" value="BLA24_20460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13233">
        <property type="protein sequence ID" value="PPT13233"/>
        <property type="gene ID" value="CYQ11_10325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="183" mass="19818" checksum="1F116090118954C8" modified="2018-01-31" version="1">MFDIRIICDSRDVDAITRRLSGAFDISAMSRPYPARGGDRVRLYITADHSQCVTVDRASAASVAQDWPDAETAYKGAPPVLKEMNNVLGLSLQLGRPGGRTPAAEREQRLRKAALLDRIALDEAATYAPDVAANAVEAAEAAALAFARADHEPGCGEQPMGHEGEASYRGYVRQAYARWRTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFK4</accession>
    <name>A0A2G1XFK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TIGR03767 family metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20635</name>
        <name evidence="5" type="ORF">CYQ11_10145</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50020">
        <property type="protein sequence ID" value="PHQ50020"/>
        <property type="gene ID" value="BLA24_20635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13202">
        <property type="protein sequence ID" value="PPT13202"/>
        <property type="gene ID" value="CYQ11_10145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042281">
        <property type="entry name" value="GpdQ_beta-strand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022506">
        <property type="entry name" value="Metallophosphoesterase_PPA1498"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03767">
        <property type="entry name" value="P_acnes_RR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304682" evidence="2">
        <location>
            <begin position="45"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="114"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="573" mass="62133" checksum="A155808C882B5FE4" modified="2018-01-31" version="1">MHRRSRRTAASHLDRRAFLAAAGAVTTAAGLDLAVGAGSSPAAAAPAGPDPDPAAAQAAAPTGAGTTLASVAAPRGSGGYRRLGDGPGWPRLVRSELAEARRGREDRRTTLASFVQFTDLHLTDVQHPLRYEFFRSGEPGAWRPHEALTLPGVVSLVERVNRVRRGPATGTPFGFVITTGDNGDENAKIEVEWFLTALSGGRMNPDTGDPNHYEGVQDSGLKLYWHPESALRDQDKALGYPRIDGYLAAARRRVTSPGLNVPWYSTFGNHDLLSGGCYPAAGSFIADVCVGNRKLQYIPPAEAKWLMEGEAAGADPKGKRIQDMLKAHRREMRTVTADPGRVPLTPRQYVAAHLDPRYTGRGPVGHGYSKANLDSGTLYYSFRISDRVIGVSLDSTDPGGHYQGSLGSAQFTWLDRTLAAHKDQYAIIFSHHPSWSMSNTVPDPGRPSEKRHGGDEVLALLGRHNNVLAWVNGHSHRNRIRPRGSFWEIATASHVDYPQLARIIEVTDNHDGTISLFTTLIESAAPYRTDFHDLSQTGLAALYRELAFNSPGADTSLAGDPTDRNTELVLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFK5</accession>
    <name>A0A2G1XFK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_20565</name>
        <name evidence="8" type="ORF">CYQ11_10215</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50007">
        <property type="protein sequence ID" value="PHQ50007"/>
        <property type="gene ID" value="BLA24_20565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13215">
        <property type="protein sequence ID" value="PPT13215"/>
        <property type="gene ID" value="CYQ11_10215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304656" evidence="5">
        <location>
            <begin position="28"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="31796" checksum="6D836524F52A38DE" modified="2018-01-31" version="1">MTTRRRSGRTTRGRVLHWIAVHTTAVAAALFFLLPFVFVFLTSVMSDEQAMSGELWPRGWHWSNYEAVLDAPGFLDWWRNSLIYAGLGTLFAVCSSLPVAYALAKFRFRGRRPAVLLVVATMMLPPQVVVVPMYLVWAQQLHLSGSLWPLIVPLAFGDAYSIFLLRQFLLTIPREYLESAKVDGCGELRTLTRIVVPMAKPGIAAVALFQFFFCWNDYFGPQIYAAQNPGAWTLSYGLESFKSAHGVNWNLTMAATALVMAPVVLVFFFAQKAFVEGVTLTGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFW8</accession>
    <name>A0A2G1XFW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21365</name>
        <name evidence="4" type="ORF">CYQ11_09420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50136">
        <property type="protein sequence ID" value="PHQ50136"/>
        <property type="gene ID" value="BLA24_21365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13083">
        <property type="protein sequence ID" value="PPT13083"/>
        <property type="gene ID" value="CYQ11_09420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="309"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="41540" checksum="48850AE06238B34A" modified="2018-01-31" version="1">MRITPLLRPFDGAGRTAAFLAAGVLVQLAAALVLAVPWLDGGPTRALSCLLALLAGFAVLGAATPVLTRMQRARFLGRRGVGIPAPGRRWSWRQVSYHLLFGPLLALGGACVLTLWAAAGAAASVYVWIWVLPPETRLGQAGYTTQAAYATVAGAAGLYAAAWLSSALQELDVRVAGARLGPSRTEQLARRVEDLTARRSEVVAATDAERRRIERDLHDGAQQRLVSLAVNLGLAKVTLGDLPDDARKVIDDAHREAKEAIEELSDLVRGLHPAVLEDRGLDAALSGLADRAPLPVGVRVDLPARPAPAIEAVAYFVVSEALANVVKHAEAARADVSVERRGGILLVVVSDDGVGGADFTGGTGLAGLAKRVASVDGTFSISSPAGGPTVVTVELPCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFZ1</accession>
    <name>A0A2G1XFZ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">BLA24_20870</name>
        <name evidence="6" type="ORF">CYQ11_09910</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50059">
        <property type="protein sequence ID" value="PHQ50059"/>
        <property type="gene ID" value="BLA24_20870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13162">
        <property type="protein sequence ID" value="PPT13162"/>
        <property type="gene ID" value="CYQ11_09910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="15014" checksum="EF4AE344E273A758" modified="2018-01-31" version="1">MSQRTLVLLKPDAVQRKLVGEIIARIERKAGWTISALELRTLDRATLEQHYAEHVGRDFYEPLMGFMSSGPVVAMVVEGERVIEGVRALAGPTDPIAAAPGSIRGDFGTITRENLIHASDSEESAQREIKIFFPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG32</accession>
    <name>A0A2G1XG32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21740</name>
        <name evidence="2" type="ORF">CYQ11_09045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50198">
        <property type="protein sequence ID" value="PHQ50198"/>
        <property type="gene ID" value="BLA24_21740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13018">
        <property type="protein sequence ID" value="PPT13018"/>
        <property type="gene ID" value="CYQ11_09045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024197">
        <property type="entry name" value="UCP030802"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030802">
        <property type="entry name" value="UCP030802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="28911" checksum="912B93309D6CC6DE" modified="2018-01-31" version="1">MTTAPTLVTSDLDRTLIYSTAALALSMPDAQSPRLLCVETYEHKPLSYMTEAAAAGLAALARTATFVPTTTRTPEQYARVRLPGPAPRFAICANGGELLVDGEPDPHWRAVVRRRLAAECAPLAEVEERLVRTADPAWLLKRRTAADLFAYLVVDRPLLPEAWVKDLADWAAGRGWTVSLQGRKVYAVPGPLTKSAAAAEVARRTGAGRTLAAGDSLLDADLLLAADRAWRPGHGELADVGWSAPHVTALQTRGVAAGEEIIEAFTAAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG42</accession>
    <name>A0A2G1XG42_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21760</name>
        <name evidence="4" type="ORF">CYQ11_09025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50202">
        <property type="protein sequence ID" value="PHQ50202"/>
        <property type="gene ID" value="BLA24_21760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13014">
        <property type="protein sequence ID" value="PPT13014"/>
        <property type="gene ID" value="CYQ11_09025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="187"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="320" mass="33296" checksum="11195A4D643897DD" modified="2018-01-31" version="1">MRPQWNDSLHGPPRVRANPAPGPAAPSTGRTWGYPHPGSGRSPDPGRRHASVESAQPARHRPETETPMTPRPVRIPALVGGVLLAGLTLGGCGSSNADDATPEERTFSISGRELTVDSDNSAIELVPGGDGKDVKVVRRFDGWALGGSAGVSWEMRGDTLKLRLTCKGISMGCEAKHRIEVPRGVAVTVKEDNGSVTARDLETPLAITTSNGSIDVRNAKGPLELRTSNGAVKARGLGSRTVSVTTSNGSVEVGAEQVPDHVETRTGNGATRITLPRAGYKVAAHSDNGGTKVDVPRDDAAGHAVTARSGSGRIDIRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGB2</accession>
    <name>A0A2G1XGB2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_22220</name>
        <name evidence="9" type="ORF">CYQ11_08565</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50272">
        <property type="protein sequence ID" value="PHQ50272"/>
        <property type="gene ID" value="BLA24_22220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12942">
        <property type="protein sequence ID" value="PPT12942"/>
        <property type="gene ID" value="CYQ11_08565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04213">
        <property type="entry name" value="HtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304930" description="GRAM_POS_ANCHORING domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="550" mass="54616" checksum="BCAECB2AEE8789B4" modified="2018-01-31" version="1">MTVTARRAALTALATATALGAAALTVPAHAAVAGAQTDGPPSGAALKDATLEWGVSKAFREYVAGVGQGRIEAGDGVRQADGNGALTFPGGTGAPAAAYPATTTFKGSVRFLARPVDAGKWQFDLTFTDVKFVADPKGGTAGSITADVTTADGRLQDDVALASVDLAGLTPKPGEGGARVYAGIPAKLTGKGAEVLSYDGTPLRQGAEIDPVTLALPAAPNGQQQRPADPAHPEGSAGDPSKGGATRPTGGVTQPTGTTPQPAGGTTQPTGDTTQQKNNGTPTGTTASGKVYDGRLDWGLLKSFRDYVTGPAKGKAELSGDAVKSGDGYRFTKGTGTYDAARPSLSDVTFSGQLLFTGRDGELDLRFGNFKVQAAGVSGKITADVATKNKATGTTTKVQDMPLAELALGTADALKAKDGLVSLSAVPATLTKEGAELLTQQGKASYKEKAALDPVSLALTVDEKVKLPDGSGTSGTGTTTTTTTSTDTGGSADTGTGTTGPASGTGSGGDATLAATGATTPTGPLLGTAAALMAAGGTAVYGARRRRARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGD3</accession>
    <name>A0A2G1XGD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21745</name>
        <name evidence="5" type="ORF">CYQ11_09040</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50199">
        <property type="protein sequence ID" value="PHQ50199"/>
        <property type="gene ID" value="BLA24_21745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13017">
        <property type="protein sequence ID" value="PPT13017"/>
        <property type="gene ID" value="CYQ11_09040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="23829" checksum="2A8B93F5BBB13125" modified="2018-01-31" version="1">MPEIKSAPLTPELYAYVLAHNPPLDPVQRALVASTRELFPDHAIKQVAQEQAPLLAFLVRLTGARHVVEVGTFTGLSALAMAQALPAGGRLIALDISEEWTAHAREAWARAGVADRIDLRIAPALDSLRALPAEPHVDLAFLDANKDGYVDYWEELVPRLRPGGLIVADNVLFMGQAADPSVTSGPGAHVRVFNEHVAADKRMESVMLTVADGLTLARRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGE2</accession>
    <name>A0A2G1XGE2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron uptake system protein EfeO</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Peptidase M75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_22215</name>
        <name evidence="7" type="ORF">CYQ11_08570</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EfeM/EfeO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50271">
        <property type="protein sequence ID" value="PHQ50271"/>
        <property type="gene ID" value="BLA24_22215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12943">
        <property type="protein sequence ID" value="PPT12943"/>
        <property type="gene ID" value="CYQ11_08570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14656">
        <property type="entry name" value="Imelysin-like_EfeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034981">
        <property type="entry name" value="Imelysin-like_EfeO/Algp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758505" evidence="3">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="5">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M75" evidence="4">
        <location>
            <begin position="140"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="40601" checksum="A18B67CBCC74755F" modified="2018-01-31" version="1">MRVLRSSAVTAVAAAAALTVVSGCAEKSDGKGSDAIKVAASDDKCEVSKTTFPSGHVKIAVENKGSKVTEVYVYGEGDRIVTERENIGPGTKTEITATIKAGSYEIACKPGMKGDGIRQKITVTGGGGAAKKTDPELDKAVAAYRAYVQQQADETVSAAQKFADAVKNGDLEEAQKNYALSRVGWERTEPVAESFGDIDPKVDVREDGLEKDQQWTGWHKLEKSLWETKQIGDDDKKLADQLMTDLKDWQKRVGTAEITPTSMANGAKELLDEVATRKVTGEEERYSHTDLTDFQANVEGAEKAYELLKPVAAKNDAALAKELDTQFANLKKLLGDYRDGDGFKSYDAVGKDDRKKLSDAVNALSEPLSKLAGAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGG7</accession>
    <name>A0A2G1XGG7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="12" type="ORF">BLA24_22555</name>
        <name evidence="13" type="ORF">CYQ11_08235</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50330">
        <property type="protein sequence ID" value="PHQ50330"/>
        <property type="gene ID" value="BLA24_22555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12883">
        <property type="protein sequence ID" value="PPT12883"/>
        <property type="gene ID" value="CYQ11_08235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="35"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="29656" checksum="111B5D0FE8E5B4E5" modified="2018-01-31" version="1">MSELRFVHLGFGADSVEYQEAWQEQRRVHAARFADEIPDTCLLLEHPAVYTAGRRTEDSERPLDGTPVIDVDRGGKITWHGPGQLVGYPILKLPRPVDVIAHVRRLEEALIRTCAELGLETTRVEGRSGVWVLGDPVDQRPAIPGLNLDFDPRLTDEEFDPRLNGPEYAPSNAGQRREDRKLAAIGIRIAKGVTMHGFSLNCDPDNTWFDRIVPCGIRDAGVTSLSNELGRRVTVGEVVPLVEKHLREILESEAPLPREVEPAQVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGP8</accession>
    <name>A0A2G1XGP8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21175</name>
        <name evidence="3" type="ORF">CYQ11_09610</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50402">
        <property type="protein sequence ID" value="PHQ50402"/>
        <property type="gene ID" value="BLA24_21175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16453">
        <property type="protein sequence ID" value="PPT16453"/>
        <property type="gene ID" value="CYQ11_09610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="7090" checksum="96F72A049DB0205A" modified="2018-01-31" version="1">MATRYGWQKSSFSGEGNACLYLAATEAIHLRESDAPNIIITATPRRLRRLISSIKSGALDRPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHB6</accession>
    <name>A0A2G1XHB6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_17655</name>
        <name evidence="5" type="ORF">CYQ11_15620</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50623">
        <property type="protein sequence ID" value="PHQ50623"/>
        <property type="gene ID" value="BLA24_17655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14122">
        <property type="protein sequence ID" value="PPT14122"/>
        <property type="gene ID" value="CYQ11_15620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304877" evidence="2">
        <location>
            <begin position="41"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="260"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="39691" checksum="8117AAEFDD142852" modified="2018-01-31" version="1">MRHTLRCSYRRYRTHRRGRAALCALCAVVSPLLVPEPSAAVKTPEKLVRVSSEVLRLARETGRVRQRYEREARAAKEQKKQADRLAQQLRGRRVVSDVLREDAGAVARAQYRTGGFTATGSPALAEDPLELLELQERDMARRERLGRMLLASEGERRALMADSLSTTASWQALDADAARLRTEKRDLEGRLANARGELNGMAQAAVSSGHCVPVDVGDLQDGQSVADRRAEVSADGWTRPLVSYELTAGFGGSGVHWSGGHTGQDFAAPTGSPVRAVGAGTVISTGCGGPFGISVVVRHAGGWYSHYAHLAAPLAVPGHKVRAGEWIGLSGTTGNSTGPHLHFEIRTTPEFGSAVEPVGWLRKRGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHF3</accession>
    <name>A0A2G1XHF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17860</name>
        <name evidence="4" type="ORF">CYQ11_15415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50660">
        <property type="protein sequence ID" value="PHQ50660"/>
        <property type="gene ID" value="BLA24_17860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14085">
        <property type="protein sequence ID" value="PPT14085"/>
        <property type="gene ID" value="CYQ11_15415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="22553" checksum="2CF0B273C1DAAA0B" modified="2018-01-31" version="1">MSRRSGILEFAVLGLLRESPMHGYELRKRLNTSLGVFRAFSYGTLYPCLKSLVANGWLVEEPGSAPEDARAASLAGRRAKIVYRLTAEGKEHFEELLAHTGPDTWEDEHFAARFAFFGQTSRDVRMRVLEGRRSRLEERLEKMRASLARTRERLDDYTLELQRHGMESVEREVRWLNELIESERAGRDKRNGPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHH0</accession>
    <name>A0A2G1XHH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17895</name>
        <name evidence="4" type="ORF">CYQ11_15380</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50667">
        <property type="protein sequence ID" value="PHQ50667"/>
        <property type="gene ID" value="BLA24_17895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14078">
        <property type="protein sequence ID" value="PPT14078"/>
        <property type="gene ID" value="CYQ11_15380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="558" mass="59904" checksum="80EB3D6B5A21FC4C" modified="2018-01-31" version="1">MAERSTTAVDVADNSGDQPLTAEADQATTDGAETGEKAGKQDDTERAESKSPARDAQPPDLHSGHKLARRYRLEECVTRLEGFSSWRAVDEKLRRAVGVHLLPADHPRARPVLAAARSAALLGDPRFVQVLDAVEENDLVYVVHEWLPDATELTPVLASGPLEPYDAYQLVSQVSQAMAAAHREGLAHLRLNPGSVLRTETGQYRIRGLAVMAALRGITSEHPQRTDTEAIGALLYAALTQRWPYEGNAHGLSGLPKGVGLIAPDQVRAGVHRGLSELAMRALVNDGATASRQEKPCTTPEELAKAVAVMPRIRPPESTYATPPTYPRAQPAVHGGAPAQAVPVAPPPPLQSRTGKALKWSVSALLIAALGLGSWQLADTLLKDGESDTPHSQSSSDDSPTEVESKPIKIEGAHEYAPDGKFQHPGQVRDSYDGDPETSWRSLTFNDGPKLAPYKDGVGIVYDLGEKKQIDGASVKLLYGGDHTTVTLYAANSPSASLDSMKKLAHGQTSTTESTISLKEPRETRYVLLWITEMPYSDSAHFSGAGYKQGVVDVQFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHN6</accession>
    <name>A0A2G1XHN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18485</name>
        <name evidence="4" type="ORF">CYQ11_14795</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50764">
        <property type="protein sequence ID" value="PHQ50764"/>
        <property type="gene ID" value="BLA24_18485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13978">
        <property type="protein sequence ID" value="PPT13978"/>
        <property type="gene ID" value="CYQ11_14795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="457" mass="49202" checksum="D0D62A76FDFC6AC5" modified="2018-01-31" version="1">MGLTSRSLLYTVVFAAVLCVGLTVWVWPRLAGRGVLPVLGRLGSILMTQLAIVAALMLAVNSWGEFYGTWNQLLGRVDKAPVNVNEMGKGGPYATVGSSKDGLVQPAGPQGLDKVGGIPRGAADKEGKVQSVRIVGQRSRAVNPAFVYLPPQYFQKQYERHRFPVMVVISGYPGGIMNLAQHLQVPQTAGKLLSENKMQPTVIVMVRPTIAPPRDTECVDVPDGPQAETFFTKDLPDALKSTYRVGADPSAWGVLGYSSGGTCALQLAMRQPDVYPAAAALSGDYKVGNDLTTGNLFGSGEAAKQKQREHDLVWRLQHMPVPRVSVLVTSSKKGEKNYGETEKFLKAVKEPMTASSIILPEGSHHFTTWRREIGPVLEWMSQQLTFPQDTADKPKPPEKKPQEGKKPEPGTSEEPRPESAGGGEEKAGGSAGDEPGEPSARPEGKGTGDRPDEEAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI61</accession>
    <name>A0A2G1XI61_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnE</name>
        <name evidence="8" type="ORF">BLA24_14155</name>
        <name evidence="9" type="ORF">CYQ11_13920</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50938">
        <property type="protein sequence ID" value="PHQ50938"/>
        <property type="gene ID" value="BLA24_14155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13841">
        <property type="protein sequence ID" value="PPT13841"/>
        <property type="gene ID" value="CYQ11_13920"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="52"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="387" mass="44287" checksum="6ADFFDEA2794245D" modified="2018-01-31" version="1">MDAGLKRELEEKVFAGERLTREDGVALYESDDLAWLGGLAHHVRTRKNGDVVHFNVNRHLNMTNVCTASCAYCSFQRKPGEKDAYTMRIEEAVRLAKAMESENLTELHIVNGLHPTLPWRYYPRSLRALKEALPNVSLKAFTATEIQHFEKISGMPAEEILDELIDAGLESLTGGGAEIFDWEVRQHIVDHDTHWEDWSRIHRLAHSKGLKGPATMLYGHIEEPRHRVDHVLRLRELQDETGGFHVFIPLRYQHDFVDMKDGKVRNRLQARTTMATGTEALKTFAVSRLLFDNVPHVKVFWVMHGVQTAQLALQHGADDMDGSVVEYKITHDADNYGTPNKLTRDDLLDLIREAGFRPVERNTRYEIIREYPGPDASLRESPQPMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI79</accession>
    <name>A0A2G1XI79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinone biosynthesis decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14130</name>
        <name evidence="3" type="ORF">CYQ11_13945</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50933">
        <property type="protein sequence ID" value="PHQ50933"/>
        <property type="gene ID" value="BLA24_14130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13846">
        <property type="protein sequence ID" value="PPT13846"/>
        <property type="gene ID" value="CYQ11_13945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="485" mass="53824" checksum="434E68719DBC59FD" modified="2018-01-31" version="1">MAYDDLRSFLRALERDGDLKRIKAEVDPYLEIGEIVDRVNKAGGPALLFENVKGAAMPLAMNVFGTDRRLLKALGLGSYDEISEKIGGLLKPELPQGFVGVREAFGKLGAMAHVPPKKVKSGDAPVQEVVLTGDDVDLEQLPALFTWPEDGGSFFNLGLTHTKHPETGVRNLGLYRLQRHDKRTIGMHWQIHKDSRNHYQVAAKRGERLPVAIAFGCPPAVTYASTAPLPGDIDEYLFAGFIQGKRIEMVDCKTVPLQVPANAEVVVEGWLEPGEMLPEGPFGDHTGFYTPQEPFPALKIDCVTMRRRPLLQSIVVGRPPTEDGPLGRATERFFLPLLKIIVPDIVDYHLPESGGFHNCAIVSIDKKYPKHAQKVMHAIWGAHMMSLTKLIVVVDADCDVHNLHEVSWRALGNVDYARDLTVVEGPVDHLDHASYQQFWGGKAGIDATAKWPEEGYTRDGGWPHMVESDPEVADRVTKRWKEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIK3</accession>
    <name>A0A2G1XIK3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_14595</name>
        <name evidence="7" type="ORF">CYQ11_13480</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51011">
        <property type="protein sequence ID" value="PHQ51011"/>
        <property type="gene ID" value="BLA24_14595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13767">
        <property type="protein sequence ID" value="PPT13767"/>
        <property type="gene ID" value="CYQ11_13480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="15300" checksum="135A9FF769CBD7FB" modified="2018-01-31" version="1">MAAKISYADVETGAELPAQSFPVTRATLVEYAGASGDFNPIHWNEKFAKEVGLPDVIAHGMFTMAEAIRVVTDWVGDPAAVVEYGVRFTKPVVVPNDDEGAVIEVSAKVAAKLDDEARTVRVDLVAKSAGQKVLGMSRAVVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIN1</accession>
    <name>A0A2G1XIN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Pimeloyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15170</name>
        <name evidence="4" type="ORF">CYQ11_12900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51112">
        <property type="protein sequence ID" value="PHQ51112"/>
        <property type="gene ID" value="BLA24_15170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13664">
        <property type="protein sequence ID" value="PPT13664"/>
        <property type="gene ID" value="CYQ11_12900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="534"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="741" mass="78203" checksum="5ACE7463B14609C4" modified="2018-01-31" version="1">MLGSTHGSLTTTSRPARVVACGERPGPAVHGMAASDRDVDVSGRPLHCDVPDLDRLFRPETVAVIGASETEGRPNTGITRRLVSWAERVGARLHPVHPTRTTVFGLPCHPSVHDLPEQIDLAVLLVGDPAPVLEELAVCKVRFAVVFASGFAETGPEGAAAQARLAATVRHSGTRLLGPNTNLNAFEHFRDDLDGPAIALITQSGHQGRPVFALQELGIRLSHWAPTGNEADLECADFISYFATRPEVGAIAAYVEGLKDGRSFLLAADRAARNRVPVVAVKVGRTETGARTAASHTGKLTGADDVVDAAMRQFGVIRVNGLDELQDTSALLARARPPRATGVAVYSISGGTGAHFADMATAAGLEIPPLSAAKQGELHQWVPEYLSVANPVDCGGHPVGDSRGRKIIDALLADPSIGVLVCPITGPFPPLSDKLAQDLVDAAEETDKLVCVIWGSPVGTEDAYRRTLLGSSRVATFRTFANCATALRAYFGHHRFTAGYRSPFDDAPRSLSPSARKAEALLRPGEQLSEHAAKQLLRAYGIRVPREQLVTSAAAAVRAAAQVGYPIVMKASGPQLAHKSELGLVKIGLTSASQVRDAYRELTEIARCEGLPLDGVLVCQLIERGVEMAVGMAHDALFGPTVAVGLGGVLVEVLDDATVRVPPFGEDQARAMLGELRGRALLDGVRGASPADVDALVETVLRVQRMAVELGDRIAELDINPLVVLGQGQGAVALDALAFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJB1</accession>
    <name>A0A2G1XJB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LytR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16235</name>
        <name evidence="6" type="ORF">CYQ11_11840</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51290">
        <property type="protein sequence ID" value="PHQ51290"/>
        <property type="gene ID" value="BLA24_16235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13484">
        <property type="protein sequence ID" value="PPT13484"/>
        <property type="gene ID" value="CYQ11_11840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="191"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="437" mass="47075" checksum="452E6961BF317913" modified="2018-01-31" version="1">MNDWPDGRTEDRRERYGRGSTGARPEGVRAMPHVQRPAPPQQYRPPQGYDSPDRHPGPPPQAAAPDDGYNTGQVYGRGSGHPQGPGGPGGPDGPGGGLRGGGRSPRTGTPDWGKRIKIGAIAFVVTVLAVSVGTYFWADGKMRREVDLGQLQERPPAGEGTNYLIVGSDSREGLSDQDKKDLHTGSADGKRTDSMMIVHTGDNGTTMLSLPRDSYVTIPAFTGKKSGKKFPAATHKLNQAYADGGPELLAQTIEFNTGLRIDHYAEIGFGGFRNLVDALGGVEMCLDKPLQDRDSGADFKAGCQELNGAQSLAFVRQRHQEADQDLGRMRNQQKFLNTLAKQAASPATILNPFRLYPVIGSGLDTLIVDKDMELWDLASMFWAMKGVTGGDGQQLTVPISNPNLPTRGDGVAVKWDTAKAKQLFEQLKKDEKVTAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJB4</accession>
    <name>A0A2G1XJB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16120</name>
        <name evidence="3" type="ORF">CYQ11_11955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51271">
        <property type="protein sequence ID" value="PHQ51271"/>
        <property type="gene ID" value="BLA24_16120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13503">
        <property type="protein sequence ID" value="PPT13503"/>
        <property type="gene ID" value="CYQ11_11955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="20891" checksum="1224A1304C13A683" modified="2018-01-31" version="1">MGRGAYALARVAVIVRAPARWLWWLGLLSAGIGVLMPGLTGRRIGVSAGAALFIVGGALAFRVHQRRYAELARGASRAGRAVFLQDRAVTLRSWRRGRRWWLLAAFPVALASSLLVPAAAGLALAGLGAGLWAKALWLGGLERREGALLWVRPEWVKGSPAGPSVRGYLTTGLAAGDALPGGARRRGGAAKAGGTAVSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD5</accession>
    <name>A0A2G1XJD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit E</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit NuoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_14330</name>
        <name evidence="9" type="ORF">CYQ11_13745</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51333">
        <property type="protein sequence ID" value="PHQ51333"/>
        <property type="gene ID" value="BLA24_14330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16544">
        <property type="protein sequence ID" value="PPT16544"/>
        <property type="gene ID" value="CYQ11_13745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="28580" checksum="C47340A4CD69760C" modified="2018-01-31" version="1">MPQLPAPDYPADVRARLEADAKDVIARYPDSRSALLPLLHLVQAEEGYVTRTGIRFCAEQLGLTTAEATAVATFYTMYRRKPGGDYQVGVCTNTLCAVLGGDAIFDALKSHLGVGNGETTADGKVTLEHIECNAACDYAPVVMVNWEFFDNQTVESATRLVDDLREGRTARPTRGAALCTYKETARILAGFPDQRPGAVEESGGAGPASLAGLRLAKGETGPARVGPPRGEPPQDERPPEHPSSHDAPQQTSASDPQHPSGPVTEEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJH8</accession>
    <name>A0A2G1XJH8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_13680</name>
        <name evidence="9" type="ORF">CYQ11_01375</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51387">
        <property type="protein sequence ID" value="PHQ51387"/>
        <property type="gene ID" value="BLA24_13680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11727">
        <property type="protein sequence ID" value="PPT11727"/>
        <property type="gene ID" value="CYQ11_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="340" mass="37895" checksum="BAC8E730AE26302C" modified="2018-01-31" version="1">MRHLGTDVTHVTRQGVTVSGRAVSTRSTRFAEEGDGYVGWALSEGQDFAECRPLLFTIAYEILGSAADAEDVVQDSYLRWHGVSREDVEHPRAYLVRTVTRQALNHLRTTRRRREDYVGPWLPEPVRTGPDVGEDAVLAESVSMAMLLVLETLSPDERAVFVLREVFGYSHREVADMVGKTEATARQIAHRAREHVRARRRRFHHDPRTAEEVVGRFLHAAGTGDVAALMSMMAPGVVHISDGGGRVSAARRPVRGREKVARFVAGVSRTSGPVTLLEFANYNALPAVQFRSGDRVDYVLLFEIADGLIHGMYAVRNPDKLSTAVVPRPLARRKDDPWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJI3</accession>
    <name>A0A2G1XJI3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16290</name>
        <name evidence="3" type="ORF">CYQ11_11785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51299">
        <property type="protein sequence ID" value="PHQ51299"/>
        <property type="gene ID" value="BLA24_16290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13475">
        <property type="protein sequence ID" value="PPT13475"/>
        <property type="gene ID" value="CYQ11_11785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="13937" checksum="1130EAC44C8CF7BF" modified="2018-01-31" version="1">MLLNLYDPVRGKSRRKDLGLSVPQLAALCGVSSMAVYKYESGELRPSFLTFIKLAHHLRISVASLVEQAGPLCQAKDADGWNVLVKAIYAAEALRHREQGTGRILMTKADARAAAEADRAGICSGAAQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJU9</accession>
    <name>A0A2G1XJU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Rifampin monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13280</name>
        <name evidence="3" type="ORF">CYQ11_01000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51480">
        <property type="protein sequence ID" value="PHQ51480"/>
        <property type="gene ID" value="BLA24_13280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11662">
        <property type="protein sequence ID" value="PPT11662"/>
        <property type="gene ID" value="CYQ11_01000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="485" mass="52249" checksum="10892652E313BF1C" modified="2018-01-31" version="1">MIDVIIAGGGPTGLMLASELRLHGVRVVVLEKLTEPTAQSRGQGLHARSVEMMDQRGLLDRFLATSEKFSVGGLFGGIVKPWPDRLDTAHPYGVATPQPVTERLLNERALELGAEIRRGCEVVGLSQDEDGVTVELAGDGGVAGGGGALVRSRYLVGCDGGRSTVRKLLGVGFPGEPAKVETLVGQMEVTEDPATIAVVVKEVNRTQLRFGVTAPDADGVVRVVAPADGVAEDRATEPTLDEFKQQLRAYAGTDFGVHSPRWLSRFGDATRQAERYRVGRVFLAGDAAHVHPPTGGQGLNLGVQDAFNLGWKLAAAVNGWAPEGLLDSYHTERHPVGAAVLDNTRAQITLMGTEPGPTALRELFSKLMDFEEVNRYVTGMITAVEIRYDFGEGHELLGRRLRDVTLKQGRRLYELMHGGRGLLLDQTGRLSVEGWADRVDHVVDVSDELEASAVLLRPDGHVAWVGDDQQDLLGQLPKWFGAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK59</accession>
    <name>A0A2G1XK59_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13570</name>
        <name evidence="3" type="ORF">CYQ11_01290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51529">
        <property type="protein sequence ID" value="PHQ51529"/>
        <property type="gene ID" value="BLA24_13570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11712">
        <property type="protein sequence ID" value="PPT11712"/>
        <property type="gene ID" value="CYQ11_01290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="231" mass="25132" checksum="945FABDD90B3335B" modified="2018-01-31" version="1">MMRIMFVGDSMTIGSAGDLTWRYRMWQHLCASHGGPFRIVGPRRELYDPAAGAPVSLDYAAADFPERAQAHLAGWGEGWHHMAPVIGEAVRAHRVDTLLISLGLIDLGFYTDAGQTAENVRRFVAAARDASPHVSAVLLPVIPNIRAREEPAFAAEVECFNELLAKAVAELDAPGSELLLASEPPGWDLDRHTYDGTHPNAEGEHRIAEAFATAMHQAWDMGGPYQRAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK78</accession>
    <name>A0A2G1XK78_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12510</name>
        <name evidence="2" type="ORF">CYQ11_17525</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51648">
        <property type="protein sequence ID" value="PHQ51648"/>
        <property type="gene ID" value="BLA24_12510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14428">
        <property type="protein sequence ID" value="PPT14428"/>
        <property type="gene ID" value="CYQ11_17525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="164" mass="18919" checksum="902B9D411BB0F279" modified="2018-01-31" version="1">MIDLGYSLSRRFPDPPQTDYRTADVHALRHDLFCGDVYLADVKTDRELSTAWGWVPVLDFAWALCDVIETIDQDPRGNRSAATQFAELDFTESTDCMVFERRFGWVDVTADWAPDEPPLTFNHRALRREARDFLQDLIADLADMHEGLADNPVVWDLQSRFPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKJ7</accession>
    <name>A0A2G1XKJ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11870</name>
        <name evidence="3" type="ORF">CYQ11_03110</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51774">
        <property type="protein sequence ID" value="PHQ51774"/>
        <property type="gene ID" value="BLA24_11870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12021">
        <property type="protein sequence ID" value="PPT12021"/>
        <property type="gene ID" value="CYQ11_03110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="467" mass="48307" checksum="9A22E61811C25739" modified="2018-01-31" version="1">MDDALRYLDTAGLRRLYAARQLSPVEFTEDTLALIADLDPALGAFVTVAADRALAEAARAEERVLRLGEAAWEGRPLLGVPLSVKDLTATEGIRTTRGSLALRDAVPGQDAPAVARLRRAGAVVLGKTTTSEGGWSAGTVNRLGPAAANPWDLSRSAGGSSGGAGAAVAAGLGIAGTGTDGAGSIRIPAAFCGVVGFKPTHGRVPYVPHCPDRLAHLGPLARTVDDAELLLRVMAGPDARDPDSLLPPHDPPAGDGPLRIAWIEGLTAPGSTGPADRQRAAVERLAAAGHHVEEIPPPFGDAYPALVTLLAAAEAAASPAADEALADPARLAVVRHGRTLSAVQLVRAEAERAELTGKLASCLERFDVLAMPTVPVPPFAVDAWHPDAPAYDDPLAWLSWAPAAFPFNMAGLPAVSVPAGFGPEGLPVGLQLAAARHHDALVLRVAKEVERANPWRDAHPGKDRDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKM0</accession>
    <name>A0A2G1XKM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11895</name>
        <name evidence="3" type="ORF">CYQ11_03135</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51777">
        <property type="protein sequence ID" value="PHQ51777"/>
        <property type="gene ID" value="BLA24_11895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12024">
        <property type="protein sequence ID" value="PPT12024"/>
        <property type="gene ID" value="CYQ11_03135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="31874" checksum="A364919E4F855474" modified="2018-01-31" version="1">MTKIKAVAFSDYGPADVLRLVDVDMPVAGPGQVRIAVRAAGVNPLDHKLRGGGLAEVFPLALPHIPGVEAAGVVEAVGEGVAGVQAGDTVLGRTLTGAYAEQALARADELVVKPVSLCWERAAALPVAAETAWRTLAELGVGEGETLLIHGAAGGVGTLAVQLARSRGVRVIGTASRFNHEYLRGLGAIPVEYGEGLADRVREAAPEGVAAALDAVGKGDAVGVSVELTGDPGRVVTIADAGGAARHGVRFSSGAPAAPDGASTTAVPALTAALALHDAGILQLPIHRKYPLAEAAEAHRASEHGHLTGKIVLTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKQ3</accession>
    <name>A0A2G1XKQ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12120</name>
        <name evidence="4" type="ORF">CYQ11_03360</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51818">
        <property type="protein sequence ID" value="PHQ51818"/>
        <property type="gene ID" value="BLA24_12120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12065">
        <property type="protein sequence ID" value="PPT12065"/>
        <property type="gene ID" value="CYQ11_03360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="420"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="518" mass="56035" checksum="7B2B000DF3259FEC" modified="2018-01-31" version="1">MPQPPNGFWAQATADPGRVVLVAPDGEGWTAHRLHAAANRLVHGLRAAGLRRGDAFAVVLPNGPEFLTAHLAATQAGLYLVPVNHHLVAPEIAWIVADSGAKALIAHARWAATVTAAADEAGLPADHRYAVGDIAGFRPYAALLDGRPDTPPEGRTLGWVMNYTSGTTGRPRGIRRPLPGKPPEEAHLGGFLGIFGIKPFDGNVHLVCSPLYHTAVLQFAAASLHIGHRLVLMDKWTPEEMLRLIETHRCTHTHMVPTQFRRLLTLSPDVREAYDVSSMRHAVHGAAPCPDHVKRAMIRWWGTCVEEYYAASEGGGAFATAQDWLRKPGTVGKAWPISELAVLDDDGKPLPAGQTGTVYMRMTTGGFAYHKDADKTESSRVGDFFTVGDLGYLDEDGYLFLRDRKIDLIISGGVNIYPAEIEAVLLAHPAVADAAVLGVPHEDWGEEVRAVVEPAEGHEPGAGLAADVLAHCARHLAGYKRPKSLDFVATMPRDPNGKLYKRLLREPHRDQGPDAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL67</accession>
    <name>A0A2G1XL67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10735</name>
        <name evidence="3" type="ORF">CYQ11_00815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51921">
        <property type="protein sequence ID" value="PHQ51921"/>
        <property type="gene ID" value="BLA24_10735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11634">
        <property type="protein sequence ID" value="PPT11634"/>
        <property type="gene ID" value="CYQ11_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="18367" checksum="E2BD7A0F2E74F24F" modified="2018-01-31" version="1">MAVMKSKTEGAEEDRRKAEGAAEGQLEAERLAGDEVDDRLAGPRSSRAVLSLTGADEGIATLTARDGNAIPKGIRVVDASGTLIAAYIALALDDLSVAKSARSAVTTALARSLDTTDHGDEAKAESPSGVITGQTGEDVPVELTPAEFRDRTVTLYASELIDLSREIRGSTTGPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLD2</accession>
    <name>A0A2G1XLD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09850</name>
        <name evidence="3" type="ORF">CYQ11_04240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52045">
        <property type="protein sequence ID" value="PHQ52045"/>
        <property type="gene ID" value="BLA24_09850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12214">
        <property type="protein sequence ID" value="PPT12214"/>
        <property type="gene ID" value="CYQ11_04240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="17029" checksum="8AD71AF9C0FD344A" modified="2018-01-31" version="1">MNELDVVGVRVEMPSNQPIVLLREVGGDRYLPIWIGPGEATAIAFAQQGMAPARPLTHDLFKDVLEAVGQQLAEVRITDLREGVFYAELVFASGVEVSARPSDAIALALRTGTPIYGSDGVLDDAGIAIPDEQEDEVEKFREFLDQISPEDFGSSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLJ4</accession>
    <name>A0A2G1XLJ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09325</name>
        <name evidence="3" type="ORF">CYQ11_27935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52113">
        <property type="protein sequence ID" value="PHQ52113"/>
        <property type="gene ID" value="BLA24_09325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16193">
        <property type="protein sequence ID" value="PPT16193"/>
        <property type="gene ID" value="CYQ11_27935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304720" evidence="1">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="103" mass="11168" checksum="C4AE9192B0CD0BA6" modified="2018-01-31" version="1">MRHPLAALGAVLLAGVLTLFAPLGARAATGTFSYFTDRGVTAHELANPVDGRCYPVGYAHGVTGNETDRDAYLYDTPDCRGAAAYFPKGFYRLETFQSVVFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM4</accession>
    <name>A0A2G1XLM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Beta-ketoacyl-[acyl-carrier-protein] synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09500</name>
        <name evidence="6" type="ORF">CYQ11_28110</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52143">
        <property type="protein sequence ID" value="PHQ52143"/>
        <property type="gene ID" value="BLA24_09500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16224">
        <property type="protein sequence ID" value="PPT16224"/>
        <property type="gene ID" value="CYQ11_28110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="6"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="407" mass="41946" checksum="BC24EF4D99323AB3" modified="2018-01-31" version="1">MTVREVAVTGIGLVTPAGIGREATWAGLLTGTGLGAHDEDLAGLPVDFSCKVPGFDGGALLGRRITWRNDRFIQLAMVAAREAVADAALDTAAWDGPRVAIVIGSASNGGDRWPAEYRHLAEGRVDAISPTALLRSLPNMVAGEVSTDLRALGPCLTTSTACASGATAIGVARDLLRSGACDIALAGGTDCARVPMGSATFHRMQALSRRRHDPAGASRPFDADRDGFVLSEGAAVLVLERPDSARARGARVRGLLSGYGASSDGYHATRPDPDGSGARRALVAALSDAGAGVSDVHHVNAHGTSTPLNDRVEADVLRGVFRSAPPVTSLKGAIGHSLGAAGAVDAACTVLSLERQLIPPTANLGRLDDGMDLDVVTKVPRRHRMEGAISNAFGFGGQNAVLFFRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLU9</accession>
    <name>A0A2G1XLU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-protein synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09545</name>
        <name evidence="3" type="ORF">CYQ11_28155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52151">
        <property type="protein sequence ID" value="PHQ52151"/>
        <property type="gene ID" value="BLA24_09545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16232">
        <property type="protein sequence ID" value="PPT16232"/>
        <property type="gene ID" value="CYQ11_28155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047474">
        <property type="term" value="F:long-chain fatty acid luciferin component ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007534">
        <property type="entry name" value="LuxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04443">
        <property type="entry name" value="LuxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LuxE" evidence="1">
        <location>
            <begin position="76"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="43156" checksum="056E4B08A00192B1" modified="2018-01-31" version="1">MNPINPHLAPVDVPDPAALAAVQELCDLTDPYAGGPAVDELFAAAMAESHAWHAERSPFFRSLYERTSPAEPFRAPLVHANFFKRHEVLSIPRDDVHLHLTSSGTTGQKSQMFFDQWTIRSAQRMVARIFERNGWIIPDQPVNYLLYSYEPARDLKLGTSFTDNYLCDFAPARQVEYALRHTGKGHEFDPFGCVAALRRFEQDDAPVRILGFPAFLWFTLERMRAMGLPPLRLPEGSLIVLGGGWKGHTDQQIGKDELYARVTEQLGIPSERIRDTFGSVEHCIPYIECDRHRLHAPVWSRVFIRSTRTLEPLPYGETGYLHLVSPYITSVPAQSVVMGDLASLHPGEECGCELNTPWFTLHGRAGVSRNKSCAVAAAELMKGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLV8</accession>
    <name>A0A2G1XLV8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_09600</name>
        <name evidence="7" type="ORF">CYQ11_28210</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52161">
        <property type="protein sequence ID" value="PHQ52161"/>
        <property type="gene ID" value="BLA24_09600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16242">
        <property type="protein sequence ID" value="PPT16242"/>
        <property type="gene ID" value="CYQ11_28210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="825" mass="87020" checksum="B6F3B7572B07D58F" modified="2018-01-31" version="1">MKGHAVAAPAALTLADYADLARRGMDAAVWDFLAGGAGEERTLAANLAAFGRVRLLPRVLTGAGRPVTMTRILGRDWAAPVGIAPLAYHTMADPEGETATARAAGRAGLPLIVSTFAGRTLEDVAAAAAGAPLWLQVYCFRDRDVTRRLVERAERAGFEALVLTADAPHLGRRLRDLRNGFRLPAGIGPANLEGAGFASPRDHSLMEFDPGLDWSAVAWLRSVSSLPVLVKGVLTAADACRAVEAGAAGVVVSNHGGRQLDGAVATLDALPEITAALAGACPVLLDGGVRRGVDVLAALALGADAVLLGRPVLDGLAVDGASGVARVLDILVGELTDAMSLSGLGSVADATPGLVRLATGTAAPEPPPPAPARSADDPEAPRTGDLRGEDLHGSLRDPVLDTMNFLNEITHRYPEAVSFAPGRPYDRFFDVEQVFTSLRRYCDHLAEQGQTPEQIRDALFQYGPTSGRIRGLIADWLRADEGIDVPAESIVVTVGCQEAMVLALRALVQGPRDALLVASPCYVGITGAARLLDIDPTPVAEREDGFHPADLEAVVRAERARGRRPRAFYVVPDHANPSGNTMSLEARHELLELAGRLDLLVLEDSPYRLVSPGIQLPTLKSLDRDRRVVHLGSFSKTLFPGARVGFAVADQTVTDRAGATRLLADELSKLKSMVTVNTSPLSQAAVAGMLLAAGGRASQLNAGTAAHYGEAMRATLRRLDACFAEPRRAGLKVRWNKPDGGFFLVVKVPFVADNAALARSAQDFGVIWTPMAYFYPQGGGEHEIRLSVSYLSLAEIDEGVGRLAAFIEHESETASGASADAVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM16</accession>
    <name>A0A2G1XM16_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08525</name>
        <name evidence="3" type="ORF">CYQ11_03780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52277">
        <property type="protein sequence ID" value="PHQ52277"/>
        <property type="gene ID" value="BLA24_08525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16332">
        <property type="protein sequence ID" value="PPT16332"/>
        <property type="gene ID" value="CYQ11_03780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="172" mass="18364" checksum="31B1DF750821D246" modified="2018-01-31" version="1">MPALWTGRATNRVQWLLAAAGAACVALGVELAVDSAWTSGLAPLVMAVVGCVAAGLLMLYGTVAFVHVAVRVDKDSLEVRCGHIGVPRTRIPLDHVVGADFAPRVTPRQWGGWGYRWRPEQGTAVVVRRGEGFVVRLGDGRTFTVTVDDAEAAVRVIRDRLRRLGAGRPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMK9</accession>
    <name>A0A2G1XMK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06710</name>
        <name evidence="4" type="ORF">CYQ11_26860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52468">
        <property type="protein sequence ID" value="PHQ52468"/>
        <property type="gene ID" value="BLA24_06710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16001">
        <property type="protein sequence ID" value="PPT16001"/>
        <property type="gene ID" value="CYQ11_26860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305608" evidence="2">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="20110" checksum="B8731FE4040901E7" modified="2018-01-31" version="1">MRAARPVPRVLLVCAGAFLACTTLTARALPPPPDPLPAPRASDGHDGLHGGMSGGLSGGLSGEIPGDPGGPGDAPVTLVARTVGTGPARCVRRTGPEHAVLHCRMERATLTDAVVTVRTGDRPTTARIAHAALSGALEVDLVRLGGRLAGLLPVRVTADLPLPVAVAPALELTDVTLAADRVSVEGGRVRDSVLLIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMQ9</accession>
    <name>A0A2G1XMQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06665</name>
        <name evidence="2" type="ORF">CYQ11_26815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52461">
        <property type="protein sequence ID" value="PHQ52461"/>
        <property type="gene ID" value="BLA24_06665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15993">
        <property type="protein sequence ID" value="PPT15993"/>
        <property type="gene ID" value="CYQ11_26815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045754">
        <property type="entry name" value="DUF6182"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19680">
        <property type="entry name" value="DUF6182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="22956" checksum="7AC9981563DD1E1C" modified="2018-01-31" version="1">MCATGSGGGVAAIAVLHEVVPEEFASSVLEFTAALSEEERRCWLGEHTRTRYLVGNPANLAGRLPPTTAHRDGRVAWYREDPRTGHRELRLLLRALRGELPADPPPYVLHVPRGLPEPDRARSPRSWRITVDVRDLTLPGYLVHLGHTLSEPAITGVLRAGDRIAVHHTRRLTPPAGGHAYLRVHRDTDDPRRLRAYAVLADESAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX5</accession>
    <name>A0A2G1XMX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_07485</name>
        <name evidence="5" type="ORF">CYQ11_27635</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52602">
        <property type="protein sequence ID" value="PHQ52602"/>
        <property type="gene ID" value="BLA24_07485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16139">
        <property type="protein sequence ID" value="PPT16139"/>
        <property type="gene ID" value="CYQ11_27635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304955" evidence="1">
        <location>
            <begin position="36"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="157"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="525" mass="57382" checksum="CE81CF3C991E3BCC" modified="2018-01-31" version="1">MAKAYGSGLAVGRRTVLRGTVAAAGAAALPPLAAAAPALALSGRPDAGWGVQTGDVTASSGLVWVRSDRPARMVVETSATESFRTVRRWAGPLLGPGTDFTGRTALRGLPPGERIHYRVLLADPDDPRRTGRPVYGTFRTAPARREGVRFVWSGDLAGQGWGINPDLGGYRIFARMRELDPDFFLCSGDTIYADNPIPATVALPGGGTWRNVTTEEKSKVAETLAEFRGAFRYNLMDEHLREFNAHVPVVAQWDDHEVHNNWYPGQLLDDARYTEKRADVLAARSLRAFSEYFPLSTRRPDADGRIYRVLRHGPLLDVFVLDMRAYRDANSPGRQPDDARGILGERQLRWLKRELTRSRAVWKVIASDMPLGLVVTDGAVNFEAVAQGDPGAPLGRELQIADLLRHIKHQRVTGTVWLTADVHYTSAQHYDPARAAFTDFAPFWEFVTGPLNAGGFPAVKLDGTFGPAQPFVKAPAAANVPPGQDSQFFGEVAIDGESGELTVRLRDERGGVLFTKVLQPGRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XND6</accession>
    <name>A0A2G1XND6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_06075</name>
        <name evidence="5" type="ORF">CYQ11_03600</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52669">
        <property type="protein sequence ID" value="PHQ52669"/>
        <property type="gene ID" value="BLA24_06075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12103">
        <property type="protein sequence ID" value="PPT12103"/>
        <property type="gene ID" value="CYQ11_03600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="38"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="345" mass="38579" checksum="9675ACAFC51435D2" modified="2018-01-31" version="1">MTTPTEPPSTARPEWELAEGKPATMLVPRFDTITDACAWLASVESELRSALHEHGAVYLRGLPLTGVEDFARVRDVLLPRRTPYREKATPRSSFGNDVYSSTDLPPAQAIRMHNENSYTLTFPGLLMFACLTAPEEGGATPVADVREVLRRVPAELVARMRAMGWVLKRHYSEHISVSWQNAFATERHSDVEKYCADNLIGWEWSDDGDLKTSQLRPGIIRHPKTGAEVWFNHLAFWSSWSLDEELRETLVDEFGADGLPFETGFGDDLPFTRQELDSINAAYEAATVRRAWQVGDLMLVDNILTSHGRDPFRGDRKIVVAMGDPVELIDCLPTVAPAGRTEQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNG8</accession>
    <name>A0A2G1XNG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05680</name>
        <name evidence="3" type="ORF">CYQ11_02145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52756">
        <property type="protein sequence ID" value="PHQ52756"/>
        <property type="gene ID" value="BLA24_05680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11855">
        <property type="protein sequence ID" value="PPT11855"/>
        <property type="gene ID" value="CYQ11_02145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304981" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="16544" checksum="0337C5F55D23BF75" modified="2018-01-31" version="1">MVAASLAALVHAAPDTSAHASHAAAAVSCAGNNTVSFSPGLSLAARRTRIGGSGAYSCLSTDPALRSGTSSISGGGRNGCFFSDATTVERITWNTGERTTVAYHGGNVQQVAGQAVVLVVGRVVKGRFKGRAVASPGPQVTVDPLRRASKGGVQLITGPSTLVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP06</accession>
    <name>A0A2G1XP06_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04815</name>
        <name evidence="3" type="ORF">CYQ11_28715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52889">
        <property type="protein sequence ID" value="PHQ52889"/>
        <property type="gene ID" value="BLA24_04815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11452">
        <property type="protein sequence ID" value="PPT11452"/>
        <property type="gene ID" value="CYQ11_28715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="12661" checksum="CE61EB7EA0243781" modified="2018-01-31" version="1">MRPGDVPYGEGTDYGGPSLRAALCVGLLVERPGLRMAGEVSLSTHPTWEGALESLPGLGKDPCLELAAVTFIDVAGATALACMAQRLGSGRRVIVDRPPPSLRRTLETFWSELAAIEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP14</accession>
    <name>A0A2G1XP14_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_04915</name>
        <name evidence="6" type="ORF">CYQ11_28615</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52977">
        <property type="protein sequence ID" value="PHQ52977"/>
        <property type="gene ID" value="BLA24_04915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11510">
        <property type="protein sequence ID" value="PPT11510"/>
        <property type="gene ID" value="CYQ11_28615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904382">
        <property type="term" value="P:mannose trimming involved in glycoprotein ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="PTHR45679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="SSF48225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="478" mass="53557" checksum="2813CCB2DBA83B91" modified="2018-01-31" version="1">MFYALAAAGGVTLAGGPAGQPRAVAGPYGAGADPRRLPGRTAAPAGAGKPEPAKAREIRSEFLHAWRGYKRFAWGHDEVEPVSGGYREFFADGQPVGLSIVEALDTHCVMGLDDETDLCLRWIDDRLDFDIDAGFQVFEATIRLVGGLLAGYLATRRRSLLDLCVDLTDRLLPAFTKSPTGMPYRFVNLRTGRVSGTVLPLAEIGTHILEFGLLSELTGDARYRRAAKRALRAVVQRRSSLGLLATSMNVETGQWADRSAVAVNPPADSFYEYLWGAWVMFDDEECRDWFRTLVDAFVRHQSERVDGLLWFKRVDFRTGALLARRQSSLGVAVLPVGGDNALAADYYRSWTAVLDAYAVIPEEIDYRRLTVLDARNELRPEYANCAFELYWQTGDPVYRTTAWRYFENLRRHHRVPHGYTVVTDVTRRPMPKGDHCPAYVFAENFKWLYLTFAGTGRFDYDRGYLSTEGKILRGSRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPC5</accession>
    <name>A0A2G1XPC5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANTAR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_04005</name>
        <name evidence="6" type="ORF">CYQ11_07310</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53051">
        <property type="protein sequence ID" value="PHQ53051"/>
        <property type="gene ID" value="BLA24_04005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12719">
        <property type="protein sequence ID" value="PPT12719"/>
        <property type="gene ID" value="CYQ11_07310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="4">
        <location>
            <begin position="143"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="23919" checksum="1ACA0CCE39A7522D" modified="2018-01-31" version="1">MTAAEPQPPVDDEPQHTPPHITRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGETAVALAREHRPDLVILDVKMPVLDGISAAERIAGESIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRFTELRALEQEVADLSQRLETRKLVDRAKSVLQTQYGLTEPAAFRWIQKTSMDRRMSMQQVAEAVIEDAQEKKQAKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPJ5</accession>
    <name>A0A2G1XPJ5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_03310</name>
        <name evidence="10" type="ORF">CYQ11_16980</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53111">
        <property type="protein sequence ID" value="PHQ53111"/>
        <property type="gene ID" value="BLA24_03310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14337">
        <property type="protein sequence ID" value="PPT14337"/>
        <property type="gene ID" value="CYQ11_16980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="741" mass="77071" checksum="DF554962CCAC6BB5" modified="2018-01-31" version="1">MPPLRGAGAGAEADDPRYAGRYRLEGRLGSGGMGVVHLARSASGLRLAVKVVHAEYAADPEFRARFRQEVAAARRVSGAFTAPVVDADPDGERPWMATLYIPGPTLSERVKRRGPLEAEAVRRLAAGLAEALRDIHRAGVVHRDLKPSNVLLAEDGPKVIDFGISRPYDSELHTETGKLIGTPPFMAPEQFQRPREVGPAADVFALASLLVHAATGRGPFASDSPYLVAYQVVHDEPDLTGVPVDLVPLIRACLAKEPADRPTPDAVMAMLSQPAADGDGEDRAVPVPSRERPVAAVEAAFTARPRPRPAAAGPSGPTGISRTPVPAPAAVPPPRPRRRLPRRHWLAVAAAVVVALAAGATWAVGRAGDVRQPSQARPTPAGAAWHPWEASVAEDAAGSGEVRAGFCSYAGGALYCSARGVQAARVEVATGKVAWRRTAAVPSPFSGSLSAPVVSGGLVHALSMDGRKLSALDPATGEPRWTRDVAAYDGRVYHAGDTVLLVAGDGTVTAVDGATNAERWRRRLPGGTKPVFSYFGGGPAFGVTISPDGRRTHVVAVDVARGATLWEWQAEGNLTAVGADSGDALYLSESDSLNHVSAVVRYAPGIGRERRVPLATRVQATSVVARGDTVYVLSSDGGLTAVGTGGAKSAGPLWRLDTSVANASPLLAADDRLYFSSGDGRLLAVDTARGALLGTTSPRLAKAGRGFLELLPAPVAAEGKVFGAAPDGSVFAVNANPAGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPY6</accession>
    <name>A0A2G1XPY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02420</name>
        <name evidence="4" type="ORF">CYQ11_04785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53209">
        <property type="protein sequence ID" value="PHQ53209"/>
        <property type="gene ID" value="BLA24_02420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12301">
        <property type="protein sequence ID" value="PPT12301"/>
        <property type="gene ID" value="CYQ11_04785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07576">
        <property type="entry name" value="R-amidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044083">
        <property type="entry name" value="RamA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="28502" checksum="0577C6553550C3AC" modified="2018-01-31" version="1">MTPLRTALYQGPSGIPSSTADTLDALARAARRAADAGARLLLANELYLTGYALGRAVRDLAEPADGPGAQAVARIAAEHGLAIGYGYPERDGDAVYNSLQVIGPDGAQLAHYRKTHLFGAYENTHFTPGQELVVQADLDGVRLGLLICYDVEFPEAVRAHALAGTELLLVPTALMRPYEIVPQTIIPARAWESQLYIAYVNRCGAERSFTFAGLSCLASPDGTVRARAGAGEDLVIADVDPQLLKASRAENTYLVDRRPELYPPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPZ2</accession>
    <name>A0A2G1XPZ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ORF">BLA24_03160</name>
        <name evidence="9" type="ORF">CYQ11_05460</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53317">
        <property type="protein sequence ID" value="PHQ53317"/>
        <property type="gene ID" value="BLA24_03160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12414">
        <property type="protein sequence ID" value="PPT12414"/>
        <property type="gene ID" value="CYQ11_05460"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="482" mass="51690" checksum="C9D7F59BF9CC4C9A" modified="2018-01-31" version="1">MTSGPQSQAAGGDVRLWGGRFADGPAEALAKLSASVHFDWRLAPYDIAGSRAHARVLRKAGLLTDDELQRMIEGLGLLEADVAAGTFVGTIADEDVHTALERGLLERLGPELGGKLRAGRSRNDQVATLFRMYLRDHARVIGGLVADLQEALVGLAEAHPDVAMPGRTHLQHAQPVLFAHHVLAHVQALSRDAERLRQWDERTAVSPYGSGALAGSSLGLDPEAVAADLGFERGSSGNSIDGTASRDFVAEFAFITAMIGVDLSRIAEEVIIWNTKEFSFVTLHDAFSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKALPLAYNRDLQEDKEPVFDSCDQLEVLLPAFTGMMATLTVHRARMEELAPAGFSLATDIAEWLVKKGVPFRVAHEVAGECVKECEARGIELDGLTDEQFAKISPHLTPEVRTVLSVPGALASRSGRGGTAPSAVAVQLQEVKADLAVQRQWADARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQK4</accession>
    <name>A0A2G1XQK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00395</name>
        <name evidence="6" type="ORF">CYQ11_07405</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53429">
        <property type="protein sequence ID" value="PHQ53429"/>
        <property type="gene ID" value="BLA24_00395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12733">
        <property type="protein sequence ID" value="PPT12733"/>
        <property type="gene ID" value="CYQ11_07405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304777" evidence="3">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="42"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="27032" checksum="771E2E29ADE2B0E3" modified="2018-01-31" version="1">MRNYLKALKRCTAVGAIALAGFSLQPGSAQAADPGPRPGPGVVGGTRAAQGEFPWMVRLSMGCGGALYTRQIVLTAAHCVNGSGANTSITATAGVVDLNSSQAVKVKSTQVLQAPGYNGTGKDWALIKLAKPVDLPTLKIADTPAYNQGDFTIAGWGAASEGGGQQRYLLKATVPFVDDATCQGAYGGSLTPAEEICAGYLDTGGVDTCQGDSGGPMFRKDDSGAWTEVGIVSWGQGCARPGYPGVYTEVSTFASDIKSAAASLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQL5</accession>
    <name>A0A2G1XQL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00975</name>
        <name evidence="3" type="ORF">CYQ11_07985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53535">
        <property type="protein sequence ID" value="PHQ53535"/>
        <property type="gene ID" value="BLA24_00975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12840">
        <property type="protein sequence ID" value="PPT12840"/>
        <property type="gene ID" value="CYQ11_07985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="598" mass="64280" checksum="29682E7D091F0E55" modified="2018-01-31" version="1">MREFSLPALYEVPADGNLTDLIRRNAALHPDVAVIGRKVDGRWQDVTAAGFLDEVRAAAKGLMASGIRPGDRVGLLSRTRYEWALLDFAIWSAGAVTVPVYETSSPEQIQWILGDSGAVACLVETPDHEAAVESVRDRLPELANIWQIERGAVERLRAAGESLTDEQVDERSALATADSPATIVYTSGTTGRPKGCVLTHRAFFAECGNAVERLKPLFNTGDSSVLLFLPAAHVFGRLVEVAAVLAPIRLGLVSDIRNLTDDLQGFRPTLVLGVPRVFEKVYNGARAKAQADGKGKVFDKAAETAIAYSRALDTPSGPSFGLRIKHKVFDKLVYGKLRAVLGGRATHAISGGAPLGERLGHFYRGIGFTVLEGYGLTESCAATAFNPWDKPRIGSVGQPLPGSVVRIADDGEVLLHGEHLFTGYWNNEAATAEALSDGWFHTGDLGTLDEDGFLRITGRKKEIIVTAGGKNVAPAVIEDRIRAHALIAECMVVGDGRPFVGALITLDEDFLPRWLEQHGKPAGLTASELSDDADLLAAVQKAVDDGNAAVSKAESVRKFRILPAQFTEESGHVTPSLKLKRNVVAKDFADEIEAIYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQM5</accession>
    <name>A0A2G1XQM5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_01035</name>
        <name evidence="10" type="ORF">CYQ11_08045</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53545">
        <property type="protein sequence ID" value="PHQ53545"/>
        <property type="gene ID" value="BLA24_01035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12850">
        <property type="protein sequence ID" value="PPT12850"/>
        <property type="gene ID" value="CYQ11_08045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="8">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="541" mass="60474" checksum="C2AB76C91E725BD0" modified="2018-01-31" version="1">MSTAADNRRKAPAGERVADWADGRLGIYSLAKANMRKIFPDHWSFMLGEVCLYSFIIIILTGVYLTLFFHPSMNEVVYHGSYAPLQGMRMSEAFKSTLDISFDVRGGLLIRQIHHWAALIFLAGMFVHMMRVFFTGAFRKPREVNWLFGFLLFVLGMFTGFTGYSLPDDLLSGTGVRFMEGAILSFPIVGTYISMFLFGGEFPGSDFVPRFFSIHVLLLPGIMLGLLVAHLILVFYHKHTQFPGPGRTNKNVVGMPLLPVYMAKAGGFFFLVFGVIAAIAAIASINPIWSIGPYRPDQVSTGAQPDWYMGFAEGLIRVMPGWEINVAGHTFVLGVFIPMMIFPLVLAAIAVYPFIESWVTGDKREHHLLDRPRNAPTRTAFGVAWLTAYMVMMVGGGNDLWATHFHLSINAITWFVRIGFFVGPVIAFVATRRICMGLQRRDKDKVLHGRESGIIKRLPHGEFVEVHEPLSQQQLHTLTAHEQPRPLELEPEVDENGVARKAGAGQRLRVKLSKGFYGEGTHIPKATAEEYQEITSGHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQP9</accession>
    <name>A0A2G1XQP9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4129 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transglutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_00800</name>
        <name evidence="5" type="ORF">CYQ11_07810</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53568">
        <property type="protein sequence ID" value="PHQ53568"/>
        <property type="gene ID" value="BLA24_00800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16417">
        <property type="protein sequence ID" value="PPT16417"/>
        <property type="gene ID" value="CYQ11_07810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="486"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="805" mass="83950" checksum="76F857418D6A100F" modified="2018-01-31" version="1">MSGRTRVAVFGAVATLAAACAMLPLVDKASWLVQAALLLAVQTAAGVVARRVPLSRPLTVAMQALVALLLLTVVFARAQAVGGFLPGPDVWREFGQLLREGADDVGRYAIPAPATSAIRLLLVGGVLVVGLVVDAVAATFRTAAPAGLPLLALYSIGAGLAQGGSGWLWFLAAAGGYLLLLLAEGRDRLSRWGRVFGGGEPGGPRSAAGFAAAGTGPALAPVRTGRRIGALALGVALAVPAVLPSIGGGLLRPDNHGDGPGGDGGGTISAVNPLVSLQNSLNQPQNREVLRYRTSAGTTEDLYLRIIALDRFDGATWSASERRVTDVPVPLPAPAGLAPGVRTEEVTTSVAAAETYGQTYLPLPYPATSVRFTGQWRYEPEGRTIVGDHGQTTKGLRYQVSSLLVTPTAQQLAAAPAPPGELLREYTRVPATLPKVVSATARQVTAGSANAYQQAVKLQDWFSTGGGFRYDTEVRSGSGPDAIARFLEEKRGFCIHFSFSMAAMARTLGIPARVAVGFTPGSPQTEGAMSIGSKDAHAWPELYFEGAGWTRFEPTPSRGTPPEYTIAQTPAVPDPGAPSAQPGRPTARPTAPSVDDGCTGRQKKLEGCPGAAQQTGGGSSGGGPSPAQLTGTAAAALVALALPLLPMLWRRRLRARRLGRDGRDARDAGERVLDAWHETTDSAWDHGIPPDESLTPRAAVARLVRSGRLNAPAAEAAGRLASAVEQVLYAPSPRTPGDPAADAELVRAGLRASAGRRGRVRAELAPRSAVRVRWAWGRCWSAVRERLLARLRAAGRLLPRSRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X956</accession>
    <name>A0A2G1X956_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4115 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30195</name>
        <name evidence="5" type="ORF">CYQ11_23285</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47787">
        <property type="protein sequence ID" value="PHQ47787"/>
        <property type="gene ID" value="BLA24_30195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15412">
        <property type="protein sequence ID" value="PPT15412"/>
        <property type="gene ID" value="CYQ11_23285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4115" evidence="3">
        <location>
            <begin position="191"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="28272" checksum="64459515AF2EE46F" modified="2018-01-31" version="1">MSIGNSPESPEDDRPSVGRILHQARISAGLTVDDVSSTTRVRIPIVHAIEQDDFTRCGGRVYARGHIRTLAHAVGLDPGPLVAQYDAEHGGRPVPTPAAPLFDAERIRPEPRRPNWTAAMVAAIVAVVGFVGFTLFNGGGKSGPVTADPASAKPSAAPSRKAGSTKASSDPKAEASASAIAGVPANKVTVKLTAENGQTWMSAKDHNGKLLEEGVLKQGDSKTFTDSKRIDLVLGNAGAVQLFVNGKEVKNVGEEGQVQRLSYTRGDPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9G5</accession>
    <name>A0A2G1X9G5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_30655</name>
        <name evidence="12" type="ORF">CYQ11_23750</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47870">
        <property type="protein sequence ID" value="PHQ47870"/>
        <property type="gene ID" value="BLA24_30655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15495">
        <property type="protein sequence ID" value="PPT15495"/>
        <property type="gene ID" value="CYQ11_23750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="215"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="426" mass="46117" checksum="16940D24B1289F46" modified="2018-01-31" version="1">MPPAPTPPTPPAPQAGAGTTLPPKPTWDPRQPVVRPFPWLRPTIRIRLTLLYGGMFLMAGVLLLTIIYLLAANALNDGSHPLIRLVEGSQVQVNGNSCPGLASTSLTRDDANRILGDCMADQRARALESLLRRSLMALMGLAVIAFAFGYAMAGRVLSPLGKITRTARRVAGTDLSRRIELGGPDDELKELSDTFDEMLDRLERAFTAQQRFVANASHELRTPLAINRTLLEVTLSDPGASPELQQLGKTLLATNERSEQLVEGLLLLARSDNEIVDRKPVDLAEVASRALDQTRSEAQTKGVELRGTRQPAVVQGNGVLLERIALNLVQNAVRYNTPDGWVEVTTQTQPGQAVLVVENTGPVVPAYEVDNIFEPFRRLRTERTGSDKGVGLGLSIVRSVARAHGGRITAEPREGGGLVMRVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9T5</accession>
    <name>A0A2G1X9T5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsule biosynthesis protein capC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31510</name>
        <name evidence="3" type="ORF">CYQ11_24555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47986">
        <property type="protein sequence ID" value="PHQ47986"/>
        <property type="gene ID" value="BLA24_31510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15611">
        <property type="protein sequence ID" value="PPT15611"/>
        <property type="gene ID" value="CYQ11_24555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008338">
        <property type="entry name" value="Capsule_biosynth_CapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14102">
        <property type="entry name" value="Caps_synth_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01759">
        <property type="entry name" value="CAPSULEPROTC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17054" checksum="2214A75DEDE959C5" modified="2018-01-31" version="1">MIPAVLTPEIAAIGIALGLLFSLVCYLTTNLSPGGMITPGWLALTLVEDLQRAAMVVGITVLTYLGTLLLQRYVILYGKRLFAAVVLTGVVLQATLYVVLQQQFPLMYANQTLGFIVPGLIAYQLVRQPRGATLLATATVSLANYVVLTAGILLGFMPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9U0</accession>
    <name>A0A2G1X9U0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_31535</name>
        <name evidence="7" type="ORF">CYQ11_24585</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47990">
        <property type="protein sequence ID" value="PHQ47990"/>
        <property type="gene ID" value="BLA24_31535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15616">
        <property type="protein sequence ID" value="PPT15616"/>
        <property type="gene ID" value="CYQ11_24585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="275"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ47990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="406" mass="42913" checksum="781B51483AFD118C" modified="2018-01-31" version="1">MPRTARDVVFVDGVRTPFGKAGPKGIYHETRADDLVVKCIRELLRRNPDLDPARIDEVAIAATTQIGDQGLTLGRTAGILAGLPQSVPGYSIDRMCAGAMTAVTAVSGGVALGAYDIALAGGVEHMGRHPMGEGVDPNPRFVSEKLVDESALFMGMTAENLHDRLPHLTKQRADEYAVRSQEKAAKAYADGKIQADLVPISVRRTSPEGGELGWGLATADEPMRPGTTLANLAGLKTPFRPHGRVTAGNAAGLNDGATASLIAAEDVARELGLPVKMRLVSYAFAGVEPEVMGIGPVPATEKALAKAGLSIDDIGLFEINEAFAVQVLSLLDHYGIADDDPRVNQYGGAIAFGHPLASSGVRLMTQLARQFEEQPHVRYGITSMCVGFGMGGTVIWENPHFDGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA13</accession>
    <name>A0A2G1XA13_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31935</name>
        <name evidence="4" type="ORF">CYQ11_24990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48062">
        <property type="protein sequence ID" value="PHQ48062"/>
        <property type="gene ID" value="BLA24_31935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15688">
        <property type="protein sequence ID" value="PPT15688"/>
        <property type="gene ID" value="CYQ11_24990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="750" mass="79552" checksum="23950EB8F818142F" modified="2018-01-31" version="1">MSTPWLRIHDDAQDGTLVVCFPPTGAHGASFAGWRAALPAGTALALVAPPGRGSRMDEEPVTGMAAYADAVAAGLRTAARGRRLVLVGVSLGALLAYETCRRLLDADVPVARLCVVAGQTPGDFHGDGGELTADDARAFVLRTGLTDPELLADPDFEDVLLPPVLADLRLSGGYDGRHAPALPVRLRAVWATDDEHVPRRAVEKWAAWTTLDCVVTAVEGGHYVHQEAPGAVVAACLDEHVPTAGGPSRRTLLGAGVTAVAGAVLTPGTATAARGRAAAPAPHPFEGDPTDPLALAVAMIRQNTSNPGDGAVTRPHALLLQGVFEAAGVATEIVPTPKQDNVHFLARVPAARPGGKKPLLLLGHSDVVPATGDTWTVEPFAGLVKDGMLYGRGALDMKGVTAAFVAALLRHVKEGTRFDRDVVLWSDCDEEQGPHGVRWFLSEHPDKVDPGVVLTEGGWVLGQRDGKTPMIAALTCNDKRSLLLRLETASYATHTSKPFTGQAVTRLGQALERLGGWRAHIRPNALSRQYFTELARATADPALAAAVRAMLDARTEAVRDRAGDEVVRLSDTPELHNAMLRTTAAFTATSAGYYPSIVPGTATAEFRVAFLPGGDDPGRTVAELRLLAGDGATLRVVGNPGETEEQAIDRLRGYLSVPDSTADTDVFRAWQEAVRQTHPGIRASACQFEAVTSAVPFRERGVPVYGIYPFTVTRDMLRRMHGTDEHIDVAALRQGTETVYQLLGRLRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP6</accession>
    <name>A0A2G1XAP6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_33090</name>
        <name evidence="4" type="ORF">CYQ11_26140</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48249">
        <property type="protein sequence ID" value="PHQ48249"/>
        <property type="gene ID" value="BLA24_33090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15879">
        <property type="protein sequence ID" value="PPT15879"/>
        <property type="gene ID" value="CYQ11_26140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="465" mass="51155" checksum="8256F4C6DB04BB41" modified="2018-01-31" version="1">MTADGTEGFDLAALLRRRGGERYELHARHLNHQLPRMLHTIGFDKVYERAEGAYFWDADGRDYLDMLAGFGVMGLGRHHPVVRKALHDVLDAQLPDLTRFDCPPLPGLLAERLLTHAPHLDRVFFGNSGTEAVETALKFARYATGKPRVLYCAHAFHGLTTGSLSVNGEEGFRRGFAPLLPDTAVPLGDLEALERELERGDVAGFVIEPIQGKGVHMAPPGYLRAAQDLLRRHKALLIADEVQTGVGRTGEFFAYQHEPGVEPDLVCVAKALSGGYVPVGATLGRDWIFKKVYSSMDRVLVHSASFGSNAQAMAAGLAVLAVMEDERIVANARDTGELLRSRLAALVGKYELLHEVRGRGLMIGIEFGRPSSLGLRSRWAMLQAARKGLFAQMVVVPLLQKHRILTQVSGDHVEVIKLIPPLIIKEREVDRFVDAFTAVMDDAHSGGGLLWEFGRTLVKQTVTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAR9</accession>
    <name>A0A2G1XAR9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_31045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48334">
        <property type="protein sequence ID" value="PHQ48334"/>
        <property type="gene ID" value="BLA24_31045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="182" mass="19549" checksum="067B5AAE2A606270" modified="2018-01-31" version="1">MELRPASEEELGGATPSGDAVAAGPQRPAQIRRAAEPEPQEAAVSLVQRLAACSEEEQEELLLELVRDQIALVLGHTDGTLVDPERGLLEMGFDSVAAVRLRNQLAQETQLSLPSQLVFEHPTAVALARHLREEMLPDDAAAAILVLEELNKLDDSILGLDPSSAARIRIAGLLQGLSAKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAW0</accession>
    <name>A0A2G1XAW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32075</name>
        <name evidence="2" type="ORF">CYQ11_25135</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48360">
        <property type="protein sequence ID" value="PHQ48360"/>
        <property type="gene ID" value="BLA24_32075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16786">
        <property type="protein sequence ID" value="PPT16786"/>
        <property type="gene ID" value="CYQ11_25135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="8771" checksum="8A003C4BB2256765" modified="2018-01-31" version="1">MRLRVEFTTEPFDLDEPPRHAVVAREVVQAAELDAVDVGPFGNTVEGGSDAVLAALDQLLRRSLAAGATRVSLQVNVVEADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB34</accession>
    <name>A0A2G1XB34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29035</name>
        <name evidence="3" type="ORF">CYQ11_06440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48426">
        <property type="protein sequence ID" value="PHQ48426"/>
        <property type="gene ID" value="BLA24_29035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12578">
        <property type="protein sequence ID" value="PPT12578"/>
        <property type="gene ID" value="CYQ11_06440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="18773" checksum="C9E134A6B8C92D0D" modified="2018-01-31" version="1">MSRRVSLPGADELFRTTGGMGLQSSSPRRKANGEKPPRVPGPGDAPDGERPGKGTEHDGHATAPAAAGQEQDAERRPTTADRATAPRAAEPATGKRRGRSGGRRPSGRERHDEKITVYVSAEELMDLEHARLVLRGEHGLAVDRGRIVREAVAVVLADLESRGDASILVRRLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH1</accession>
    <name>A0A2G1XBH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29070</name>
        <name evidence="3" type="ORF">CYQ11_06405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48583">
        <property type="protein sequence ID" value="PHQ48583"/>
        <property type="gene ID" value="BLA24_29070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16380">
        <property type="protein sequence ID" value="PPT16380"/>
        <property type="gene ID" value="CYQ11_06405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="20702" checksum="9BD7D9B41D4C50F0" modified="2018-01-31" version="1">MYGLWKPRVLGAWRVPAAGPVIMAVNHTHNIDGPMLMGTAPRPVHFLIKKEAFVGPLGPFLRGIGQLEVDRTGTDRTAVTGALQLLEQGGVLGIFPEGTRGEGDFASLRAGLAYFAVRSGAPIVPVAVLGSGERSSRVIRALPPLRSGVDVVFGDPFEAGDGSGRRTRKALDEATVRIQRHLGAHLADAKRLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH8</accession>
    <name>A0A2G1XBH8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
            <ecNumber evidence="2">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pafA</name>
        <name evidence="4" type="ORF">BLA24_29700</name>
        <name evidence="5" type="ORF">CYQ11_05775</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48529">
        <property type="protein sequence ID" value="PHQ48529"/>
        <property type="gene ID" value="BLA24_29700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12472">
        <property type="protein sequence ID" value="PPT12472"/>
        <property type="gene ID" value="CYQ11_05775"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="453" mass="52175" checksum="474E7BB49F658C1D" modified="2018-01-31" version="1">MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDSVTELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLLCGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDITGRRKVRLASGREASALEVQQEYYEKAVDFCERRGIRTGTVERVLELWGRSLEAIRDEDLDRISTEIDWVMKYQLIERYRAKNNITMSHPRIAQIDLAYHDIHRRRGLYYLLEKRGQAARVCNDLKIFEGKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVEKLIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBM3</accession>
    <name>A0A2G1XBM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28225</name>
        <name evidence="4" type="ORF">CYQ11_07250</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48610">
        <property type="protein sequence ID" value="PHQ48610"/>
        <property type="gene ID" value="BLA24_28225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12709">
        <property type="protein sequence ID" value="PPT12709"/>
        <property type="gene ID" value="CYQ11_07250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="29334" checksum="4034FE2EC49F8701" modified="2018-01-31" version="1">MTEEHEPAATRRETGETESSRASRGWWDRNADEYQTEHGGFLGDDRFVWGPEGLDEADAALLGPASALKGLDVLEIGAGAAQCSRWLAARGARPVALDLSHRQLQHALRIGADFPLVEADAGALPFADGSFDLACSAYGAVPFVADPVRVMREVHRVLRPGARWVFSVTHPVRWAFPDEPGPEGLSVAASYFDRTPYVEQDETGRAVYVEHHRTVGDRVRDIVAAGFRLVDLVEPEWPAWNTQEWGGWSPLRGHLIPGTAIFVCERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBN9</accession>
    <name>A0A2G1XBN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose biosynthesis protein CelD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29290</name>
        <name evidence="3" type="ORF">CYQ11_06185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48589">
        <property type="protein sequence ID" value="PHQ48589"/>
        <property type="gene ID" value="BLA24_29290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12541">
        <property type="protein sequence ID" value="PPT12541"/>
        <property type="gene ID" value="CYQ11_06185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="160"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="40629" checksum="C1B3EC8FD0A138E4" modified="2018-01-31" version="1">MDISVYRPGELTAADRTAWSAMQVRAVEDGSPQLTNPFLAPEFALAVGRCRRGARIAVVREEGAPVAFFPYQRSSLGVGRAIGMGVSDAQGLVHRPGFQWDTRELLQACGLSLWEFDHLVEGQKPFEVVASGSYASPVIDVDQGFDRYLSALRKQSPKFTRTTLAKERKLGRDAGEVRYVHDERDPGVLRALIGWKSAQYRRTGRADRFARPWITQLVEQLFHTRTETFSGLLSVLYAGGRPVAAHFGLRSTTVLACWFPAYDPEFARYSPGLVLHLRMAEGAAAEGMAYLDLGRGGKAYKDSLKTRELSVSEGWVTRRHPVALGYRARRAPVRALRNTVLSRPELFEPADRLLKRVGSLRESGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBX8</accession>
    <name>A0A2G1XBX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27180</name>
        <name evidence="3" type="ORF">CYQ11_18475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48764">
        <property type="protein sequence ID" value="PHQ48764"/>
        <property type="gene ID" value="BLA24_27180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14588">
        <property type="protein sequence ID" value="PPT14588"/>
        <property type="gene ID" value="CYQ11_18475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="542" mass="59245" checksum="5F7C5BE76D5DCC11" modified="2018-01-31" version="1">MSHSVPQDSPTEATRLLCAGTYLDIEFRRRVIEELVEHAERPVAPSLGVDAVPVLTHALRARGQDTLTALIMLALWVGFISVDVASTPEGAEAPVPIWSTAYAVVCFMHWTAQAAAGRGSSVYVVDKSTLRQALKGSGGLRALRVLLPVGPPLLAIAYWVFTFWALSQGADNWVGIIFPLLLVLPVWMHRARVAAVMRTELSREAFRRRPRAYPSSSYHRRIAQAIDREQYSGLTIYDPSRPFIGMGVPYEPWSFALELKRRKGADGADGNAPGTPPFTGRTVVELIRPRLEALRKAAAETSRDRLKDLEIEEFVYLPVGPPRPRVAYDDHTVSRHLAESVNEGGEARRYFLRVRVGAWDEQVVVSVLVRVHTQGGMLVLEVVPHILTPVRPEFRAVDVIAARGEDDLLRDGVRALLSAPAAGFAAAVSTIRSAVSGFRTWLADPRRAVPDGPAHSVRELAGVPEVSLFQEMDISRYVKTVQDRIASGVREALRSQGFETDRFEQQIVQISEGGIYIGSMSGGAVAQGAGAEAKNLTGSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC08</accession>
    <name>A0A2G1XC08_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000157">
        <property type="protein sequence ID" value="PHQ48748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48748">
        <property type="protein sequence ID" value="PHQ48748"/>
        <property type="gene ID" value="BLA24_28090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase_6" evidence="2">
        <location>
            <begin position="149"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="326" mass="36355" checksum="5B98937D6393E0DE" modified="2018-01-31" version="1" fragment="single">IQDGRAVGAYSGAAPVGPNIPQNVRDDYKKEQGHISEVNDLIDEALRQASQADKKASAELDKLATKINVSDTNVAHNYIETETAHLEIDMIRGSIPVGKDPHLVRAWWDGLTPEQHKALMLADPVTIADLTGLPDDVGKEIRGRDGKIDRVEMVRYALDHWNKPDDLKFENNCANFASSALEAGGMQKKFDTWLGPRGDNTWGRESGIGIDWWDQRAYHSRSWASAKYLRNFLTDNGGEEVPRSQARPGDLIFYEQVAEDPGKGGEPQGETYHAAVVTSVTPDGDIKLSQHTGEWQNVSLEAREHVATRNHGEQRIHIVRPHPNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC32</accession>
    <name>A0A2G1XC32_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TetR_C_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48755">
        <property type="protein sequence ID" value="PHQ48755"/>
        <property type="gene ID" value="BLA24_27125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_31" evidence="1">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="112" mass="12115" checksum="67D549624E3ADAD7" modified="2018-01-31" version="1" fragment="single">AEATAGERYEAVWSEVVRTFSTHRPLWLASVEAFVQAEHAPELRRQIAAGHTEGRRVLAAQLLGTPQEDVPDGTAHTLGTVLLALLQGVMMQSLADPAAHRRRPTSPRGCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCY5</accession>
    <name>A0A2G1XCY5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23515</name>
        <name evidence="2" type="ORF">CYQ11_22555</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49061">
        <property type="protein sequence ID" value="PHQ49061"/>
        <property type="gene ID" value="BLA24_23515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15293">
        <property type="protein sequence ID" value="PPT15293"/>
        <property type="gene ID" value="CYQ11_22555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="81" mass="9154" checksum="75F958435CC785E8" modified="2018-01-31" version="1">MERDSQLELYRLVADQLKEAHTRVRTLQVPEGVRMALSRQLLAITASAKHDLSGAARRLDRLMNDLDEGRFPQEPGTGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD24</accession>
    <name>A0A2G1XD24_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24030</name>
        <name evidence="3" type="ORF">CYQ11_22040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49143">
        <property type="protein sequence ID" value="PHQ49143"/>
        <property type="gene ID" value="BLA24_24030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15207">
        <property type="protein sequence ID" value="PPT15207"/>
        <property type="gene ID" value="CYQ11_22040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="10118" checksum="6A8A8F7CD0DCABFC" modified="2018-01-31" version="1">MEIAVTLALILGLIAAGALLIHRLNAQHDERIANFRYSGVLPWRDSRSRKRPRSAIDPAGPLLARNRREQPHGDRGRRRVFSGRRRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD85</accession>
    <name>A0A2G1XD85_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24145</name>
        <name evidence="4" type="ORF">CYQ11_21930</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49161">
        <property type="protein sequence ID" value="PHQ49161"/>
        <property type="gene ID" value="BLA24_24145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15189">
        <property type="protein sequence ID" value="PPT15189"/>
        <property type="gene ID" value="CYQ11_21930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="142" mass="15776" checksum="B29C8101DEABD229" modified="2018-01-31" version="1">MTKAKDIMHPGAQWITRDETLSRAAQVMEMLDVGALPVSDENSRLCGIVTDRDIVVKCLARGRDPAKVTAGELCEGTPRWIDADADVQEVLNEMERHRIRRLPVVENKRLVGMISEADVVRQLPDDQVAEFTSAIYSSPTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD97</accession>
    <name>A0A2G1XD97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_24375</name>
        <name evidence="6" type="ORF">CYQ11_21695</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49206">
        <property type="protein sequence ID" value="PHQ49206"/>
        <property type="gene ID" value="BLA24_24375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15144">
        <property type="protein sequence ID" value="PPT15144"/>
        <property type="gene ID" value="CYQ11_21695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="165"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="235" mass="24631" checksum="2A1295A321B2E00E" modified="2018-01-31" version="1">MTGGSGERAVGAEGGGRIRVVVAEDQAAVRSGLVLILRSAPGIEVVGEAGDGEEAVRLARELRPDLVLMDVQMPRLDGVSATRMVSEGGFADVLVLTTFDLDEYVFGALRAGAAGFLLKDSEAAELVEAVRTVARGEGLISPAVTRRLIAEFARPAPVRPANAPDPGMLDALTRREREVLVCLGEGLSNAEIAGRLSMAEATVKTHVSRLLAKLGLRSRVQAAVLARELGLVQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDE2</accession>
    <name>A0A2G1XDE2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">BLA24_24405</name>
        <name evidence="11" type="ORF">CYQ11_21665</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49211">
        <property type="protein sequence ID" value="PHQ49211"/>
        <property type="gene ID" value="BLA24_24405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15138">
        <property type="protein sequence ID" value="PPT15138"/>
        <property type="gene ID" value="CYQ11_21665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="306" mass="33028" checksum="64BCB87EA041988D" modified="2018-01-31" version="1">MGAQLRVYKRRIKSVTATKKITKAMEMIAASRIVKAQRQVAASTPYASELTRAVTAVATGSNTKHALTTEVENPVRAAVLLVTSDRGLAGGYSSNAIKAADQLTTRLKAEGKEVVTYIVGRKGVAYYSFRERPVVQSWTGFTDSPTYADAKKVAGPLIEAVQQDTAEGGVDELHIVFTEFVSMMTQTPVDKRLLPLSLETTVEESEAVKDKILPLYDFEPSDEGVLDALLPRYVESRIYNALLQAAASEHAARRRAMKSATDNAEELIKSFTRLANAARQADITQEISEIVGGASALADATAGSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE25</accession>
    <name>A0A2G1XE25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25970</name>
        <name evidence="2" type="ORF">CYQ11_20095</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49487">
        <property type="protein sequence ID" value="PHQ49487"/>
        <property type="gene ID" value="BLA24_25970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14862">
        <property type="protein sequence ID" value="PPT14862"/>
        <property type="gene ID" value="CYQ11_20095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="9723" checksum="748C2CF52A24E744" modified="2018-01-31" version="1">MTHDWPVAATEDEAIRTVELVSLPGVTLHVDHDDWDYHITVSPDHAPGHLRRIIAAAQSRGLDLLDQDACVPVLLADDSVRLYLQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE36</accession>
    <name>A0A2G1XE36_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25905</name>
        <name evidence="2" type="ORF">CYQ11_20165</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49475">
        <property type="protein sequence ID" value="PHQ49475"/>
        <property type="gene ID" value="BLA24_25905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14875">
        <property type="protein sequence ID" value="PPT14875"/>
        <property type="gene ID" value="CYQ11_20165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="246" mass="25195" checksum="813EFC91D127215C" modified="2018-01-31" version="1">MALNDNATLVVGNGNYLTAPVGTAMPGDLLVPTSPWQNVGHTSLEDVFGITSEGGEATTIGTLQNKSLRTKYSARTESITFTLNQFDTAALRLYFGANAPLLPDGSIGVPADPQPTQAAFMAIFIDGESHFAVYAPKAEIYRADDMAIGDTESLAGLPLGVKPMVYGANSWTYAVTPLGGTVATGASAGTPGSFIPTGAVAPADLAALASVIATPTAKWATGQYVSLGDSSKAFWDGSKWVAGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE56</accession>
    <name>A0A2G1XE56_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_26150</name>
        <name evidence="14" type="ORF">CYQ11_19490</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49517">
        <property type="protein sequence ID" value="PHQ49517"/>
        <property type="gene ID" value="BLA24_26150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14763">
        <property type="protein sequence ID" value="PPT14763"/>
        <property type="gene ID" value="CYQ11_19490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="53"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="336"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ49517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="560" mass="60736" checksum="F5BAC3D415A1331C" modified="2018-01-31" version="1">MSAPSARSGFAYTDLLPLGEDTTPYRLVTSEGVSTFEADGRTFLKVEPEALRKLAAEAMHDISHYLRPAHLAQLRKILDDPEASANDRFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQNVLTEGEDEKALSHGVFDAYTELNLRYSQMAPLTMWDEKNTGSNLPAQIELYATDGGAYKFLFMAKGGGSANKSFLFQETKAVLNEASMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEYALKTAKYASAHYLDELPEEGSPLGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVRVVRLPRHGASCPVAIAVSCSADRQALAKITAEGVFLEQLETDPARFLPETTDEHLDADGDVVEIDLNRPMDDILAELTKYPVKTRLSLTGPLVVARDIAHAKIKERLDAGEEMPQYLRDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSKQVTDACGAHGGFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFIVVDDKGNDFFVDPSPAPTFTSIPVRGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE99</accession>
    <name>A0A2G1XE99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26170</name>
        <name evidence="3" type="ORF">CYQ11_19470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49521">
        <property type="protein sequence ID" value="PHQ49521"/>
        <property type="gene ID" value="BLA24_26170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14759">
        <property type="protein sequence ID" value="PPT14759"/>
        <property type="gene ID" value="CYQ11_19470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="224" mass="23958" checksum="BC2FE49079149737" modified="2018-01-31" version="1">MSGDDQRDYDGYARLGLDRSGQAEAFDAIGDRYDEAFPHKEGQLAAGAWLAAALPPGSRILDVGCGTGLPTARQLVEAGHEVVGNDLSPGMLDLARVNVPGATFHLGDLADLRDGHLGTFDGIAAFFALLMLPRPEIPHALRMLHGLLRPGGLLALSMVEADVDDYAIPFLGNTIRVSGYLRDELRQVVRDAGFEIAGESSPAYAPASTDVPPEIQLFLNLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF64</accession>
    <name>A0A2G1XF64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19565</name>
        <name evidence="4" type="ORF">CYQ11_11230</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49841">
        <property type="protein sequence ID" value="PHQ49841"/>
        <property type="gene ID" value="BLA24_19565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13383">
        <property type="protein sequence ID" value="PPT13383"/>
        <property type="gene ID" value="CYQ11_11230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="32776" checksum="33C965E13892AA0B" modified="2018-01-31" version="1">MFDSRHIKTFHAVVTAGSYSAAARALGYTQPAITQQMKALERSVGTPLFTRVGRRMRLTEAGEALARHAEVILDSLAAARQQMTSLTRLRAGRVRVCAFPSAGATLIPEALARLAADHPGVRVELLEGEPPDSLGRVVRGECDITLAFTYPGLHEQIPEELAEIPLLEDQLTVVLPLGHPLARRRAVKLSDLAEERWIAGCLRCRTNFLHECAEQGFAPDIAFTTDDNLVVQSLVAEGLGVAMMPGLVLSFLRHDKITGRALDPASRRQVSAYVLREHLKIPATALVLDELKAVAARRVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF67</accession>
    <name>A0A2G1XF67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3311 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19795</name>
        <name evidence="3" type="ORF">CYQ11_10995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49882">
        <property type="protein sequence ID" value="PHQ49882"/>
        <property type="gene ID" value="BLA24_19795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13342">
        <property type="protein sequence ID" value="PPT13342"/>
        <property type="gene ID" value="CYQ11_10995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="59" mass="6837" checksum="37162DD21D950773" modified="2018-01-31" version="1">MLWLLAPYVLYLGVLPLVDRVRPTVLGLPFLFFWLLLATLLTPLAVFLAWRGDRRRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFF8</accession>
    <name>A0A2G1XFF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20335</name>
        <name evidence="9" type="ORF">CYQ11_10450</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49968">
        <property type="protein sequence ID" value="PHQ49968"/>
        <property type="gene ID" value="BLA24_20335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13255">
        <property type="protein sequence ID" value="PPT13255"/>
        <property type="gene ID" value="CYQ11_10450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="26928" checksum="8BD6AB01AFD302B7" modified="2018-01-31" version="1">MNLTLRIWRQRTPQDAGAMTTYEVTGISEDMSFLEMLDHLNEELILEGDEPVAFDHDCREGICGACGMVINGQAHGPERTTTCQLHMRHFRDGDTIDVEPWRAAAFPVVKDLVVDRSAFDRIIAAGGYVSAPTGSAPDAHATPVPKPAADLAFEHAECIGCGACVAACPNGSAMLFTSAKVVHLNVLPQGAPERESRVTDMVGAMDDQGFGGCTNTGECAVACPKGIPLQSIATMNREYLRATLKGARRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFL2</accession>
    <name>A0A2G1XFL2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">BLA24_20625</name>
        <name evidence="15" type="ORF">CYQ11_10155</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50018">
        <property type="protein sequence ID" value="PHQ50018"/>
        <property type="gene ID" value="BLA24_20625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13204">
        <property type="protein sequence ID" value="PPT13204"/>
        <property type="gene ID" value="CYQ11_10155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ50018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT13204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="342" mass="36019" checksum="42070FB5A317608C" modified="2018-01-31" version="1">MRIGIVGATGQVGGVMRKILAERKFPVDELRLFASARSAGTTLPWQGTEITVEDAATADYTGLDIVLFSAGGATSRALAEKVAGQGAVVIDNSSAWRRDPEVPLVVSEVNPHAVANRPKGIIANPNCTTMAAMPVLRPLHAEAGLTALIATTYQAVSGSGLAGVAELEGQVCEIGGRAAELTHDGEAVPFPAPGVYKRPIAFNVLPLAGAIVDDGSHETDEEQKLRNESRKILEIPDLKVSGTCVRVPVFSGHSLQVNARFERPISVERAYELLQDAPGVELSEIPTPLQAAGKDVSYVGRIREDETVDHGLALFLSGDNLRKGAALNAVQIAELVAAELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ6</accession>
    <name>A0A2G1XFQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20715</name>
        <name evidence="2" type="ORF">CYQ11_10065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50035">
        <property type="protein sequence ID" value="PHQ50035"/>
        <property type="gene ID" value="BLA24_20715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13187">
        <property type="protein sequence ID" value="PPT13187"/>
        <property type="gene ID" value="CYQ11_10065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="104" mass="11061" checksum="50F33FC4037E2F7F" modified="2018-01-31" version="1">MAGAGADRRSYDTGASSEVQGSLQGIISRLETVLTERDGAVKAAMADFRADGVSDAYHDKEVRWNRAATEVRQIMTLLRSTMEKNDGTAQSTLAKAKAAVDAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG84</accession>
    <name>A0A2G1XG84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_21975</name>
        <name evidence="11" type="ORF">CYQ11_08810</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50237">
        <property type="protein sequence ID" value="PHQ50237"/>
        <property type="gene ID" value="BLA24_21975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12978">
        <property type="protein sequence ID" value="PPT12978"/>
        <property type="gene ID" value="CYQ11_08810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="32"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="341"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="571" mass="58180" checksum="F2AA7A817F310C22" modified="2018-01-31" version="1">MAVTAPHEAGEDARAGDRILAGAVRHSAARTLVLALIATAGTGAALLSPAVLGHTLDLLLARRGDTTRWVLLCAGLVCAPAALDALDELLGATTTARTTAWLRHRALGHVLAAGPAATAAVPPGDLVSRVVGNAAHAAAAPASLAGTVTAVVGPLGGVVALGLIDPWLVVVFLAGAPLLALLLRAFARASTDSLTAYQRLQGDLAGRLLEAVGGARTIAAAGTAGRERARVLAPLPGLSRHGHRMWRVQGRSTAQAVTLVPLLQIAVLAVAGLELHRGRLSVGDVLAASRYAALATGVGMIVGHVNTLVHSRTAARRLAGVHALPAVRHGSRRLPPGDGTLRLRGVSARRGGRQVLSDVDLVVPGGTTLAVVGRSGTGKSVLAELAGRLADPDTGEVTLDGVPLPDLAHDELRREVGYAFARPALLGGTIGGTIGFGSRTPAPHELTAAARAACADGFIRKLPAGYATPCAAAPLSGGEAQRLGLARAFAHAGRLLVLDDATSSLDSVTEHEVARALVDDVTAGTRVIVAHRATTAARADRVAWLDAGRVRAVGTHGELWRLPAYRAVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGA8</accession>
    <name>A0A2G1XGA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biliverdin-producing heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22225</name>
        <name evidence="4" type="ORF">CYQ11_08560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50273">
        <property type="protein sequence ID" value="PHQ50273"/>
        <property type="gene ID" value="BLA24_22225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12941">
        <property type="protein sequence ID" value="PPT12941"/>
        <property type="gene ID" value="CYQ11_08560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="24341" checksum="7871CA8DAC76EADC" modified="2018-01-31" version="1">MDASAPAPFSTLIRTASHEQHAEAENSSFMSDMLGGRLGVAAYRRYTEQLWFVYRALESASGALAADPVAGPFIRPELARTPQLARDLAHLGGPRWDAGLEPLPATATYAARIAECARTWPAGYVAHHYTRYLGDLSGGQIIRGTAERTWGFARKGDGVRFYVFERIGNPAAFKREYRALLDALPVDELEKQRVVEECRRAFALNTAVFHELGRQFPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGI1</accession>
    <name>A0A2G1XGI1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_22065</name>
        <name evidence="6" type="ORF">CYQ11_08720</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50249">
        <property type="protein sequence ID" value="PHQ50249"/>
        <property type="gene ID" value="BLA24_22065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12966">
        <property type="protein sequence ID" value="PPT12966"/>
        <property type="gene ID" value="CYQ11_08720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758849" evidence="3">
        <location>
            <begin position="29"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="4">
        <location>
            <begin position="88"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="343" mass="36429" checksum="79809514FAFE3286" modified="2018-01-31" version="1">MSSRRRGTAAAALSVAAALSLAACGSSGGDGAGKDGGAGSKSVAQGGKDFGKAAEETAKMGTDAAPGQFPRTITHALGTTEIKKRPERVVVLDVGELDNVVSLGIKPVGWAPSEGSQEIPAYLKKDAGEPKSVGTINNLNLEAINALKPDLILGSKLRAEKNYKDLSKIAPTVFSVRPGFTWKENYLLNAAALDKRADAEKQLADYEAKARKLGQDVGEKKPTISMVRYLPQVTRLYARQSFIGTVLADAGLPRPENQRADTLAVEVGPERIDQADADWIFTGVYGDPGRTKQDAAEGNPLWKNLTAVREGRAKPVQDETWYLGLGVTAANSVLDDLRGFLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGK5</accession>
    <name>A0A2G1XGK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-myo-inositol dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20255</name>
        <name evidence="3" type="ORF">CYQ11_10530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50378">
        <property type="protein sequence ID" value="PHQ50378"/>
        <property type="gene ID" value="BLA24_20255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16474">
        <property type="protein sequence ID" value="PPT16474"/>
        <property type="gene ID" value="CYQ11_10530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="33203" checksum="F074666FD39D28D6" modified="2018-01-31" version="1">MPPALDRIRVGSAPDSWGVWFAEDPAQVPWRRFLDEVAEAGYAWIELGPYGYLPTDPRVLREETDRRGLKVSAGTVFTALHRGPAVWEETWEQVARVAELTRAMGAGHLVVIPSFWRDDKTAELLEDPELTPDQWRLLARGMERLAREVLDAYGLALAVHPHADTHIDTEAHVERFLDATDPDLVHLCLDTGHYAYCGGDSVKLIETYGERVGYLHLKQVDPDVLADVTRRGTPFGPAVRQGVMCEPPGGVPALEPVLAAAQGLGVDLFAIVEQDMYPCPPDKPLPIARRTRAFLRSCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGR1</accession>
    <name>A0A2G1XGR1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BLA24_22635</name>
        <name evidence="17" type="ORF">CYQ11_08155</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50434">
        <property type="protein sequence ID" value="PHQ50434"/>
        <property type="gene ID" value="BLA24_22635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16424">
        <property type="protein sequence ID" value="PPT16424"/>
        <property type="gene ID" value="CYQ11_08155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00544">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ50434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT16424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="40853" checksum="B882BF2327A5692C" modified="2018-01-31" version="1">MTLLGTGAPEGLPRPGCPCASCATATGDDARAATALLVDDALLLDLTPGPAFAAARAGRSVAGVRQVLLSHPHDGPAVEFPAGLPTPVRVPDGRELSVISGHRVRAVALDAPGTGYEVTGPDGERLLYLPPGGAPAGMSGAPGPYAMVLLDAVGRPDALARLRETGAAGPTTDVVAVHLDHDTPPGRELHRRLAAVGARAVPDGTTLVVGDFHAVPDVPRRTLVLGGARSGKSVEAERRLDAFPGVLYVATSGSREGDLDWAARVARHRERRPGSWRTAETCDLVPLLAADGPPLLIDCLALWLTDAMDSVGAWDDATWHNGGAAALAGRVAELVAAIRATPRTVVLVSNEVGSGVVPATASGRRFRDELGRLNAMVGDECEHVVLVVAGQALPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGY2</accession>
    <name>A0A2G1XGY2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_16875</name>
        <name evidence="7" type="ORF">CYQ11_16410</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50504">
        <property type="protein sequence ID" value="PHQ50504"/>
        <property type="gene ID" value="BLA24_16875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14240">
        <property type="protein sequence ID" value="PPT14240"/>
        <property type="gene ID" value="CYQ11_16410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="41639" checksum="D1A969628C531B62" modified="2018-01-31" version="1">MNVLDIVLLIAAVWFAVIGYRQGFVVGVLSVIGFLGGGLVAVYALPVIWDSTTDDAQPGTIAAIAAVAIVIVCASVGQAATTHFGNKLRRHITWSPARALDATGGALVNVVAMLLVAWLIGSALAGTSLPTLGKEVRSSKVLLGVARVVPPQANTWFADFSTVLAQNGFPQVFAPFSTEPITSVPPPDPELAGSPVVTVAQRSIVKVVGNAPSCGKVLEGSGFVFAPHRVMTNAHVVGGVDEPTVQIGGQGRLHDAKVVLYDWKRDIAVLDVPSLDAPELHFASGEAESGKSAIVAGFPENGSYDVRAARVRSRVQANGPDIYHRGNVRRDVYSLYATVRQGNSGGPLLTPDGKVYGVVFAKSLDDPDTGYALTAAEVRQDALSGRTATARVNTQGCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGZ8</accession>
    <name>A0A2G1XGZ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16895</name>
        <name evidence="6" type="ORF">CYQ11_16385</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50506">
        <property type="protein sequence ID" value="PHQ50506"/>
        <property type="gene ID" value="BLA24_16895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14238">
        <property type="protein sequence ID" value="PPT14238"/>
        <property type="gene ID" value="CYQ11_16385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001018">
        <property type="entry name" value="Beta-lactamase_class-B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00743">
        <property type="entry name" value="BETA_LACTAMASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="4">
        <location>
            <begin position="39"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="276" mass="28734" checksum="6914698E4B9768DD" modified="2018-01-31" version="1">MTYATDLPGQPRGAAASGPATARATCVLAPNPSAMTLDGTNTWILAEPDSGLAVVVDPGPPDEQHLRNVIATAEAAGNRVALTLLTHGHADHSGGAARFAELTGTKVRALDPALRLGGEGLGVGDVVTTGGLELHVISTPGHTSDSLCFHLPADRAVLTGDTVLGRGTTIVAHPDGRLGDYLDSLRRLRALAVDEGVETVLPGHGPVLDDARGAVEYYLAHRAKRLAQVETAAENGHRTAEEVVAVVYADVDRSLWPAAELSVRAQLDYLDEHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH98</accession>
    <name>A0A2G1XH98_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_17545</name>
        <name evidence="13" type="ORF">CYQ11_15730</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50605">
        <property type="protein sequence ID" value="PHQ50605"/>
        <property type="gene ID" value="BLA24_17545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14140">
        <property type="protein sequence ID" value="PPT14140"/>
        <property type="gene ID" value="CYQ11_15730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="198"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="33337" checksum="372A8E3E47D4B803" modified="2018-01-31" version="1">MPATCYTYLGPEGTFTEAALRTLPEAATRQLVPKVSVPAALDAVRNGEAAAALVPIENSVEGGVTATLDELATGEPLMIYREVVLPIAFALLVRPGTALADVKTVTGHPVAQPQVRNWLAAHLPDAVWESAASNADGARLVREGRYDAAFAGEFAAATYGLEPLVTDIHDARNAETRFVLAGRPARPAARTGADRTSLVVWLGDDHPGALLELLQEFAARGVNLMRIESRPTGEGMGRYCFSVDCEGHITDRRVGETLMGLKRTCPKVRFLGSYPRAGVDPDDLSTASERAGTSDDAFVAAADWLARCQDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHC1</accession>
    <name>A0A2G1XHC1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17770</name>
        <name evidence="3" type="ORF">CYQ11_15505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50644">
        <property type="protein sequence ID" value="PHQ50644"/>
        <property type="gene ID" value="BLA24_17770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14101">
        <property type="protein sequence ID" value="PPT14101"/>
        <property type="gene ID" value="CYQ11_15505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="153" mass="16852" checksum="C50F3F257347DBF9" modified="2018-01-31" version="1">MSRTPDPALFGLAQGWCALSALHSRIEAHIERALQAHHDLSVREFSVLDVLNRQHDGEGGHLRMNEVADAVVLSQSATTRLVNRLEDRGLLTRYLCLTDRRGIYTDVTDAGRSLLEEARPTNDTALREALEDASRRTELAPLVAAVESLAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHF9</accession>
    <name>A0A2G1XHF9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Murein biosynthesis integral membrane protein MurJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mviN</name>
        <name evidence="10" type="ORF">BLA24_17890</name>
        <name evidence="11" type="ORF">CYQ11_15385</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50666">
        <property type="protein sequence ID" value="PHQ50666"/>
        <property type="gene ID" value="BLA24_17890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14079">
        <property type="protein sequence ID" value="PPT14079"/>
        <property type="gene ID" value="CYQ11_15385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="757" mass="79481" checksum="595AFC344B97F68B" modified="2018-01-31" version="1">MNAPYDGDRGQGAGGEQRESYPQFPPAPTPPGAPQPGPYAPGPNVPEQGPYARDPYLRDAYASDPYPAHDPSAQDPVTDARYDRAVPPGAYQQAPANQYASDPQMWAQPQAPRDEAPQGPHGDPDATQLMSVGGFGEQPASPSGDQPRRDAFAHLYRDQQQQPYEPQPPSGQQIPAPGQYGSPVPPPQPPPVEPTAEPDPAAASAAPAKSGGRAASLLKSSALMAAGTMVSRLLGFGRNLVMAAAIGVGTLNDDYQVANVLPTMIYILVGGGALNAVFIPQLVRSMKNDEDGGEAYANRLLTLVVVLLAGVTAVCVLGAPFFIQAMSPTIAADPDRMDVAVAFARYCLPTMFFMGVHVVLGQILNARGRFGAMMWTPVLNNIVIIATFGAFIWAFGPFTDSKVSAGTITPEGVRLLGIGTLLGLTVQALAMLPYLRDAGFRIRPRFDWRGQGLGKAAGLAKWTFFFVLANQLSMVVVTQLATKAGALAEKAHHTGTGITAYNFALQLWQMPQAIITVSVMTAVLPRISRAAHDGDVSAVRDDLSHGLRTSAVAIVPCAFAFLALGVPMATLMFSSGSGAEGATNIGFILMAFGLGLIPYSAQYVILRGFYAYEDTRTPFYNTLIVAAVFAAASVLSYLVLPARWAVAGMAASYGLGYAVGVGVAWRRLRARLGGDLDGSHVIRTYARLGGACVPAALIGGAVAYGIGQVLGNGVVGSLAALAGGGLILIAVFYIAAKRMRIEELTAMVGMVRGRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL2</accession>
    <name>A0A2G1XHL2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_17685</name>
        <name evidence="7" type="ORF">CYQ11_15590</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50629">
        <property type="protein sequence ID" value="PHQ50629"/>
        <property type="gene ID" value="BLA24_17685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14116">
        <property type="protein sequence ID" value="PPT14116"/>
        <property type="gene ID" value="CYQ11_15590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="370" mass="39432" checksum="199AE48A89A19496" modified="2018-01-31" version="1">MTAPGKHQVSRADPSRRGSRQGRAGIRDVAAAAGVSITTVSDALNGKGRLPDATRRHVREVADRLGYRPSAAARTLRTGKSGLIGLTVTTYGDEPFTFTEFAYFAEMARAATSAALARGYALVILPATSRHDVWSNVALDGTVVVDPSDHDPVVSDLVRQGIPVVSDGRPAGSLPVTAWVDNDHEAAVLGILDHLAAAGARRIGLLTGTTTDTYTRLSTTAYLRWCERVGQDPVYEEYPAHDPCAGAVAADRLLARPDRPDAVYGLFDPNGTDLLAAARRYGLRVPDDLLLVCCSESTVYATTEPPITTLSLKPRRIGTAVVQLLIDAIEGLDTGRPVEQVIPTELIVRTSSERRPPRTVVSAPRGPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHM1</accession>
    <name>A0A2G1XHM1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18195</name>
        <name evidence="3" type="ORF">CYQ11_15080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50717">
        <property type="protein sequence ID" value="PHQ50717"/>
        <property type="gene ID" value="BLA24_18195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14030">
        <property type="protein sequence ID" value="PPT14030"/>
        <property type="gene ID" value="CYQ11_15080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043857">
        <property type="entry name" value="DUF5819"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19136">
        <property type="entry name" value="DUF5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="24667" checksum="88AE2F5AB4E49244" modified="2018-01-31" version="1">METDTGHERTGGGLGLFELSLPARVVVAGGVAVVTLATAVHLAMMFLHVAPSNTVSKRHASAVNDYVYPEFEQNWKFFAPNPLQQNVAVQARAELRSPDGGTTVTPWADLSARDGADIAHNPLPSHTRQNELRRAWDFYTANHDAQEQPSGLRGRLSEEYIRRIVASRLGAGQQDRPLGRVQVRSVTSPIAPPPWSDEQAETKPVYRVLGWWPVTGADLAEASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHT4</accession>
    <name>A0A2G1XHT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_18750</name>
        <name evidence="6" type="ORF">CYQ11_14530</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50808">
        <property type="protein sequence ID" value="PHQ50808"/>
        <property type="gene ID" value="BLA24_18750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13934">
        <property type="protein sequence ID" value="PPT13934"/>
        <property type="gene ID" value="CYQ11_14530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23273" checksum="AF68851E6783AC6E" modified="2018-01-31" version="1">MTIKVLIVDDQMMVREGFSVLLGAQPDIEVVGEAVNGREAVRKVAELRPDVVLMDIRMPELNGLEATREIVAADADAKVLVLTTFDLDEYVYQALRAGASGFLLKDASASQLAEGVRVVAEGEALLAPTVTKRLILEFSRLGAPRAPSQVGDLTERETEVLVLVARGRSNSEIAAHLVVAESTVKTHVSRILVKLGLRDRTQAAVFAYEAGLVTPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHT6</accession>
    <name>A0A2G1XHT6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18400</name>
        <name evidence="3" type="ORF">CYQ11_14880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50751">
        <property type="protein sequence ID" value="PHQ50751"/>
        <property type="gene ID" value="BLA24_18400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13991">
        <property type="protein sequence ID" value="PPT13991"/>
        <property type="gene ID" value="CYQ11_14880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="317"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="715" mass="76984" checksum="5197E2C4C645AE15" modified="2018-01-31" version="1">MRTEDVLAAVSTGLWHWDNASRTVTFDAEAARLLGLPAERVELSEPAARARFHAVDWVQVQGVIRLAAAEGTLAEARMRVVDDAGRVLRTVRSRTRPGTEARHRLTGTIEEVPEPQQGTSPAPAAVTGDWRRNREAFLLDAGRALAEARSTSEVLRVAATLSMPGFEPSGLAVFASEGNRVKLIGHHGYEPGAMEDFRDEPMDTGYPAAEVIRTGRAVYLPSPEDYARRFPGLYPKVAKFGRRSWAFLPLINAGRTIGAWMAGFSMPVTFTPDERSVLTTVARMLAQALGRASAHESERELTMGLQRSMMPTVEPDIPGMSVAARYVPTGGGLEVGGDWYDMIPLPGEGKIALVIGDVQGHDVRAAGLMGQLRIALRAYASEGHHPDAVLSRASRFLAGINGGDAGDEDAVADQRFATCLYIEATPATGMLVIARAGHPDPAIRLSDGTMLVRPTAGGLPLGIVPDTDYPTTRMVLEPGETMMVCTDGLIETGGHDLETGWARLREVVEGHSADAGDGSLEKLADSLVQAVHGPPSHYTTGPLIDRREDDIALLLLRRDLPAAAAPGQAPPAPRPPRRTVLTIAQAEPERIAEARQQIRELMYDWPDQDQTDSAVLMVSEMVTNVLVHTDGDAILIAEISGEPGVRSVRVDVADSSDELPHRRHPGEMASSGRGLVLMELLAGAWGVDPQGEGKNIWFELYETAGDGETRFEGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI06</accession>
    <name>A0A2G1XI06_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1203 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18445</name>
        <name evidence="2" type="ORF">CYQ11_14835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50759">
        <property type="protein sequence ID" value="PHQ50759"/>
        <property type="gene ID" value="BLA24_18445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13983">
        <property type="protein sequence ID" value="PPT13983"/>
        <property type="gene ID" value="CYQ11_14835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009593">
        <property type="entry name" value="DUF1203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06718">
        <property type="entry name" value="DUF1203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034110">
        <property type="entry name" value="DUF1203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="18790" checksum="51ADC309C87E8F00" modified="2018-01-31" version="1">MTTTTPAYEARAIDPAVLRRLREQDDAGFTREPFTDTEGGAPLRCCLRHSAAGEHIALVSYAPLRRWAAETGAAPGAYDECGPVFVHADACGGQTSGPGYPAAMHGARRMLRAYDARGHILGGTLVEIPVERVAEVDDALRGVFADPEVALVHVRAVEFGCFLMEVRRAADLNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI52</accession>
    <name>A0A2G1XI52_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome C biogenesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Cytochrome c biogenesis protein ResB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_14100</name>
        <name evidence="10" type="ORF">CYQ11_13975</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50928">
        <property type="protein sequence ID" value="PHQ50928"/>
        <property type="gene ID" value="BLA24_14100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13852">
        <property type="protein sequence ID" value="PPT13852"/>
        <property type="gene ID" value="CYQ11_13975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="76"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="594" mass="64178" checksum="BE52E6D9469CE16D" modified="2018-01-31" version="1">MAKTDSTPSAPAPEEPDAGAGAAGAQMSTAPAEDREQAVPGSFGGMRGPGALGWLAWTARETFGWCRWFWRQLTSMRVALLLLFLLSLATIPGSLVPQNSVDPLKVEQWKEKHESLTSVYDKLGLFHVYSSVWFSAIYILLFVSLIGCIVPRTWQFVGQLRGRPPAAPRHLTKMPAHATWHTDADPERVLAAAHRALRRRRFRTVAAGDAVSAEKGYLREAGNLLFHVSLIVLLVAFASGQLWKSEGGKLVVEGDGFANNLTQYDDFKSGSLFTADDLDPFDFDLDSFSGTYERTGPQKGTPRDYAAHVTYRDTPDGPRRKATIKVNEPLETGRSKVYLIGHGYAPIVTVRDGQGNVAFRGPIPSLPLDSNVTETSVLKVPDYRDKDGKEDDLGFKGNFVPTLDLRTGRMASQFPALDNPALVLTAYRGNLGIDAGLPQSVYQLDVSRMKQFTEPDGSKFAKALKVGDTMKLPDGAGELHFDAIRQWATFQVSQKPGNELALAGAGAALVGLAGSLFIQRRRVWVRAVAGEDGRTVVEVAGLGRSESARLPEELTGIVAALQPDAPPAAADDTAGTPTEEPAEDPAEPSEGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI91</accession>
    <name>A0A2G1XI91_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_14190</name>
        <name evidence="5" type="ORF">CYQ11_13885</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50943">
        <property type="protein sequence ID" value="PHQ50943"/>
        <property type="gene ID" value="BLA24_14190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13836">
        <property type="protein sequence ID" value="PPT13836"/>
        <property type="gene ID" value="CYQ11_13885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304674" evidence="3">
        <location>
            <begin position="27"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="391" mass="40184" checksum="6B039DDB3EDD3547" modified="2018-01-31" version="1">MHLRSTALAALTALAVALGLPGTTAAASAPGSPQAAGAPGDVVSSAPTSFHPLPGQPTNTRAWHITYRSTTAKGTPNVVSGTVIVPQDGRTGPRPLVTYAVGTVGLGDACAPSAGFPYGTTVEANLIQQLTLRGWAVAVTDYEGLGTPGDHTYTVGPAEGHAVLDAARAAQRLPEAGLGGRGPVGIMGYSQGGQASAWAAELHASYAPELDVRGTASGGVPADLLKTADYDDGGIGAGLILMAAAGQDAAHPELRLASYLNDKGRFYVDFLKKNCVVVGVVAGLFKRISDVTVKNPLHEADWQAVLRASALGTRAPDRPVYLYHGLVDELIPYAVGKRLRADWCAKGVAVQWKPLPLAEHVLGAVTESIPAANWLADRFAGRPAGGNCQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI97</accession>
    <name>A0A2G1XI97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_14270</name>
        <name evidence="2" type="ORF">CYQ11_13805</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50956">
        <property type="protein sequence ID" value="PHQ50956"/>
        <property type="gene ID" value="BLA24_14270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13822">
        <property type="protein sequence ID" value="PPT13822"/>
        <property type="gene ID" value="CYQ11_13805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="202" mass="22186" checksum="A97F397E942A84A7" modified="2018-01-31" version="1">MLFDVTRSEFAGIFGEDRIATLPVTAFPPAAADTEGARLLQTVGLPSGTFPLRQPDEHDGLLPLVQDVVHIEDFEDAAGDWPVIGWLVNAHLALDPVSGMVHAFDPDEGTVRELHTDVSSLVQVTFRFQRLLAEFTFSGDEGDEEADFERLDGEADRIRRETSGIDPLPFQDDETVWSVVGDEIAMGRRFKGDSPGARSLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIA3</accession>
    <name>A0A2G1XIA3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_14230</name>
        <name evidence="2" type="ORF">CYQ11_13845</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50950">
        <property type="protein sequence ID" value="PHQ50950"/>
        <property type="gene ID" value="BLA24_14230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13829">
        <property type="protein sequence ID" value="PPT13829"/>
        <property type="gene ID" value="CYQ11_13845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="22395" checksum="5CBBB8266B2A25A3" modified="2018-01-31" version="1">MLTIHAAPLVLPVGAAPVVDGAVAVDGDTVASVGPYEQVAAAHPAARVRRWPGVLTPGLRQWHGLWLLTRAYHPDPREYDELGDRPLTGERLAALDMTETRRAGSVRRGLQQMLRHGTTALAGSFHEPVVATAVARSGLRVVSALRAPGVLAGEPDLDPLRETFDLAGAVGTPLTVGARADLAAFDAPDEAALLAAGAGTCVATVLGGRLVYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIA5</accession>
    <name>A0A2G1XIA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14440</name>
        <name evidence="3" type="ORF">CYQ11_13635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50988">
        <property type="protein sequence ID" value="PHQ50988"/>
        <property type="gene ID" value="BLA24_14440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13790">
        <property type="protein sequence ID" value="PPT13790"/>
        <property type="gene ID" value="CYQ11_13635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="72"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="360" mass="38531" checksum="5BB5773FB9985E43" modified="2018-01-31" version="1">MAETAEPTKTSPPEVLSLVPKAEARQTAKDFKSDQEVRWCPGCGDYAILAAVQGFMPELGLAKENIVFVSGIGCSSRFPYYMNTYGMHSIHGRAPAIATGLATSRQDLSVWVVTGDGDALSIGGNHLIHALRRNVNLKILLFNNRIYGLTKGQYSPTSEVGKVTKSTPMGSLDAPFNPVSLALGAEASFVARTVDSDRKHLTEVLRAAAAHPGTALVEIYQNCNIFNDGAFEVVKDKQQAEEAVIRLEHGQPVRFGADGAKGVVRDRATGDLKVVAVTPENEADVLVHDAHAATPTTAFALSRLADPQTLHRTPIGVFRDVSRPVYDTLMADQLEAAVEQKGKGDLAALLAGNDTWTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIE6</accession>
    <name>A0A2G1XIE6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">BLA24_14725</name>
        <name evidence="11" type="ORF">CYQ11_13345</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_058046827.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51032">
        <property type="protein sequence ID" value="PHQ51032"/>
        <property type="gene ID" value="BLA24_14725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13745">
        <property type="protein sequence ID" value="PPT13745"/>
        <property type="gene ID" value="CYQ11_13345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="107" mass="11815" checksum="133C46039C5E2B85" modified="2018-01-31" version="1">MTEAVVTSKTFSDPRDLLVKPVVSEKSYALLDENKYTFIVDPRANKTQIKQAVEAVFSVKVTGVNTINRQGKRKRTKTGFGKRANTKRAIVTLAEGDRIDIFGGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIH7</accession>
    <name>A0A2G1XIH7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="7" type="ORF">BLA24_14885</name>
        <name evidence="8" type="ORF">CYQ11_13185</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51062">
        <property type="protein sequence ID" value="PHQ51062"/>
        <property type="gene ID" value="BLA24_14885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13715">
        <property type="protein sequence ID" value="PPT13715"/>
        <property type="gene ID" value="CYQ11_13185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="148" mass="16493" checksum="E880EFD5BFEA2771" modified="2018-01-31" version="1">MRTYSPKPGDVTRQWHIIDAQDVVLGRLASQAASLLRGKHKPVYAPHMDMGDFVVIINADKVHLSGNKKSQKMAYRHSGFPGGLRAVRYDELLDKNPEKAVEKAIKGMLPKNSLGRQMLSKLKVYSGDQHPHAAQQPVPFEITQVKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ1</accession>
    <name>A0A2G1XIJ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="7" type="ORF">BLA24_14805</name>
        <name evidence="8" type="ORF">CYQ11_13265</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51047">
        <property type="protein sequence ID" value="PHQ51047"/>
        <property type="gene ID" value="BLA24_14805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13730">
        <property type="protein sequence ID" value="PPT13730"/>
        <property type="gene ID" value="CYQ11_13265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="60" mass="6924" checksum="76582F78FEF663C1" modified="2018-01-31" version="1">MARLKVTQVKSYIGSKQNHRDTLRSLGLKKINDVVVKEDRPEIRGMVHTVRHLVTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIL5</accession>
    <name>A0A2G1XIL5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">nnrD</name>
        <name evidence="15" type="synonym">nnrE</name>
        <name evidence="18" type="ORF">BLA24_14960</name>
        <name evidence="19" type="ORF">CYQ11_13110</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51076">
        <property type="protein sequence ID" value="PHQ51076"/>
        <property type="gene ID" value="BLA24_14960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13701">
        <property type="protein sequence ID" value="PPT13701"/>
        <property type="gene ID" value="CYQ11_13110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="393"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PHQ51076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PPT13701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="481" mass="48022" checksum="59BF31A16F9D0937" modified="2018-01-31" version="1">MRTGYSVETVRAAERALMARLPEGALMQRAAAGLAAACADLLGRRVYGARVVLLVGSGDNGGDALYAGARLARRGAGVSAVLLAPDRAHAGGLRALRAAGGRVVASSAAADALRRAHLVVDGIVGIGGRGGLRPEAETLVAAAREGGAPVVAVDLPSGVDADGGEVRGAAVRADATVTFGTYKPGLLVDPAREHAGALRLVDIGLGPHLPAEPDVEALQHADVAGFLPLPDAESDKYRRGVVGVVAGSARYPGAAVLAVAGALSGGAGAVRYAGPAVEAVIARFPETLVTAGPPSKAGRVQAWVVGPGLGDGAEARQALEDVLASGVPVLVDADGLRLLDPRALRARTAQTVLTPHAGEAAALLGRSREEAESARLSSVRALAERFGVTVLLKGSTTLVAEGPAPVRVNPTGTPWLATAGSGDVLSGLVGSLLAAGLPGRDAASVGAYLHGLAARALGPAPITSLAVADELRKVWLDVTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIN8</accession>
    <name>A0A2G1XIN8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">BLA24_14825</name>
        <name evidence="6" type="ORF">CYQ11_13245</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51051">
        <property type="protein sequence ID" value="PHQ51051"/>
        <property type="gene ID" value="BLA24_14825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13726">
        <property type="protein sequence ID" value="PPT13726"/>
        <property type="gene ID" value="CYQ11_13245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="29570" checksum="BB76F3A214ED0269" modified="2018-01-31" version="1">MVEIKTPEQIAKMREAGLVVAAIHAATREAAVPGATTKDLDEVARKVLAEHGAKSNFLGYGGFPATICTSVNEVVVHGIPDTKTVLKDGDIISIDAGAIVDGWHGDAAFTAFVGTGHAPELVELSRVTEESLWAGIAAMKKGARLVDISRAIEGYIRRQPRPASGRYGIIEDYGGHGIGTEMHMDPHLLNYVSRKRGKGPKLVPGLCLAIEPMVSLGTARTHVLEDDWTVLTDDKSWSSHWEHSVALTEEGPLVLTAVDGGRAKLAEYGVTAAPDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIT5</accession>
    <name>A0A2G1XIT5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15295</name>
        <name evidence="3" type="ORF">CYQ11_12775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51135">
        <property type="protein sequence ID" value="PHQ51135"/>
        <property type="gene ID" value="BLA24_15295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13643">
        <property type="protein sequence ID" value="PPT13643"/>
        <property type="gene ID" value="CYQ11_12775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13910" checksum="03A48572A6ADF803" modified="2018-01-31" version="1">MTVRRVVPNIHSEAVQESRDFYGLLGFEEVMNHGWIMTLASPASPAAQISVMTHDETAPVAPDLSVEVDDVDAAYAAVRESGAEIVHLLQDEEWGVRRFFVRDPDGRVVNVLSHRRSGDPATPTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIU0</accession>
    <name>A0A2G1XIU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_15495</name>
        <name evidence="7" type="ORF">CYQ11_12580</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51164">
        <property type="protein sequence ID" value="PHQ51164"/>
        <property type="gene ID" value="BLA24_15495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13613">
        <property type="protein sequence ID" value="PPT13613"/>
        <property type="gene ID" value="CYQ11_12580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="28119" checksum="476F6F8FE0C26475" modified="2018-01-31" version="1">MAASTASPGRMPALYLSHGAPPLADDPVWPGELAAWSARLPRPAAVLMVSAHWEEAPLALGATTTVPLEYDFWGFPERYYAVGYAAPGAPDLAARVRGALRGPGTPVQDLPDRGLDHGAYVPLVEMYPAADVPVLQMSLPTLDPRRLMDVGRKLAPLRDEGVLIVGSGFFTHNLAALRHAGPRPPAWSSEFDAWGREALAAGDVDALLDFGNKSPAAHLAHPRTEHFAPLFVTLGAAEDELHTQRSVIDGFWAGLAKRSVQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIU4</accession>
    <name>A0A2G1XIU4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Valine--pyruvate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15445</name>
        <name evidence="3" type="ORF">CYQ11_12630</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51156">
        <property type="protein sequence ID" value="PHQ51156"/>
        <property type="gene ID" value="BLA24_15445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13621">
        <property type="protein sequence ID" value="PPT13621"/>
        <property type="gene ID" value="CYQ11_12630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="66"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="428" mass="45909" checksum="E898440ECA86EA74" modified="2018-01-31" version="1">MQLSTWGTSMSRLSGIRSIMDDIAAAVGEPSDGPWFNLSPGNPAMIPEVVDTWRRLAEESVRDDFFGAGGQYGPSRGTNALVGAIVRYFNAAYGWGIGPENVLVGPGSQMLAFMAVNAYTGPTDRGERKLVLPCVPDYTGYQGLSIAERGIVGVEPVVTVEDGTVGDGRQFRYGVDLAAVRRATATGGAMLLSSPSNPTGRSLDAAELDGLVAIAAERDIPLIVDHAYGQPFPGVVDTPLTPVLHPNVVNCFTFSKAGMPGERIGFAIGPADAIDAMVSFTANAALHAPQLMQNAAARALDSGGIDVLTAKVIKPYYRAKRRLAEELLREHLPESVDWRLHRSDGGMFCWLWIDHDWFDDLVAYRALKSKNVFIVPGRHFFVGPLTTPFLADHGTRCVRLSLSGPEDVIATGVARLGATLTEQRRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIU5</accession>
    <name>A0A2G1XIU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15165</name>
        <name evidence="4" type="ORF">CYQ11_12905</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51111">
        <property type="protein sequence ID" value="PHQ51111"/>
        <property type="gene ID" value="BLA24_15165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13665">
        <property type="protein sequence ID" value="PPT13665"/>
        <property type="gene ID" value="CYQ11_12905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="291" mass="30317" checksum="333971E221E324E5" modified="2018-01-31" version="1">MNFSPREATTEPDGHGEPAGFDVPSGSDESLVRHTTDSGVAWITLNRPQALNAIAADQREQLISSFSAASADPTVRAVVITGAGKGFCAGADLRGTQGPTPAERVPGDVARMIREGAQRLVSAVLDCEKPVIAAVNGTAAGLGAHLALACDLVLAAESARFIEVFVRRGLVPDGGGAYLLPRLVGPQRAKELMFFGDALSAAEAERFGLVNRVVADADLAEEAAAWAARLAQGPTRALALTKQLVNASLAADRAASFAAEATAQEINMMTTDAAEGVAAFRERRSPRFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIV3</accession>
    <name>A0A2G1XIV3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15265</name>
        <name evidence="4" type="ORF">CYQ11_12805</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51130">
        <property type="protein sequence ID" value="PHQ51130"/>
        <property type="gene ID" value="BLA24_15265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13648">
        <property type="protein sequence ID" value="PPT13648"/>
        <property type="gene ID" value="CYQ11_12805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304902" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="44"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="20141" checksum="5E6F95B1708A92E0" modified="2018-01-31" version="1">MRKNTRARRLLTTSTALAAGGIMFLPAPDVAQPAAAPGSPTQVSGASFQFVNGQTGKCATLAGGVSTDNNVELLQFNCDTHPSRRWRLANWDGSSYQIVNRQTGKCATVAGGVSTDNNVGLVQFNCDSHPSRRWRLTNWNGRSYQVVNVQTGKCATVAGGVSTDNNVGLVQFTCDTHPSRRWTLRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIY6</accession>
    <name>A0A2G1XIY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15090</name>
        <name evidence="4" type="ORF">CYQ11_12980</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51099">
        <property type="protein sequence ID" value="PHQ51099"/>
        <property type="gene ID" value="BLA24_15090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13678">
        <property type="protein sequence ID" value="PPT13678"/>
        <property type="gene ID" value="CYQ11_12980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304923" evidence="1">
        <location>
            <begin position="24"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="40995" checksum="92DC47B12924D197" modified="2018-01-31" version="1">MPTRTTHPRLTSALAVVCCTVTAWVTTACGGVVARSPVLQDLVSERTVPGAAELSQDAHGTVRFATAGVADVRTGRRIGLTDRFRAGSITKTVVATVTLQLVAEHRLNLDDPVAEHLPAPNATALTGAERGRTVTVRQLLTHTSGLFSYTDDDAFFRRFFGQGFTEHRYESHTPDALLGTALAHAPYGPPGTRYRYSNTDYLLLGMVIRQVTGHSYAVEATRRIIVPLRLTGTSFPGTRATLPLPHGRAYSAATGDAPGAKGLTDVTDLNPSAAGAAGEMVSTLPDLNRFFAALLSGTLLPPAELRAMRDTSLSGGSYGMGVFPVRLPCRRTVWGHNGEITGSYVQTLGTADGRHVVSFRTNSDTRLSSLAQTKLLATEFCSTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ50</accession>
    <name>A0A2G1XJ50_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">galK</name>
        <name evidence="9" type="ORF">BLA24_15865</name>
        <name evidence="10" type="ORF">CYQ11_12210</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51230">
        <property type="protein sequence ID" value="PHQ51230"/>
        <property type="gene ID" value="BLA24_15865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13546">
        <property type="protein sequence ID" value="PPT13546"/>
        <property type="gene ID" value="CYQ11_12210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="8">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="291"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="39707" checksum="4596D0BCF6ECE715" modified="2018-01-31" version="1">MTAAQAARAFGEVYGTPCEGVWAAPGRVNLIGEYTDVNEGLVMPLALPRLTWVAARARPDGRLRLHSAAAAGVVVELGPGEPAAPGAVRGWAAHPAGVAWALREAGYPVGGADLHVESEVPLGAGLSSSAALQVATALALDGLHGLGLGRPELARLAQRAENAFVGVPCGIMDQTAAACCVEGHALHLDTRSLAARPVPLGLAAAGLRLLVMDTRVAHELGEGAYARRRAGCEAAARALGVRALRDVAYERLAEALAEVEAAGGAERHGVRPGPLVRHVVTENRRVEETAALLDAGDPRAVGPLLTAGHASLRDDFAVSCPELDLAVATAVGAGALGARMTGGGFGGSAVALVEEAAVTEVGEAVRAAFAAAGHRLPHVFPVTAGPGAHRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ78</accession>
    <name>A0A2G1XJ78_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_16205</name>
        <name evidence="11" type="ORF">CYQ11_11870</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51286">
        <property type="protein sequence ID" value="PHQ51286"/>
        <property type="gene ID" value="BLA24_16205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13489">
        <property type="protein sequence ID" value="PPT13489"/>
        <property type="gene ID" value="CYQ11_11870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040868">
        <property type="entry name" value="DraK_HK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18092">
        <property type="entry name" value="DraK_HK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="209"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="414" mass="44595" checksum="5DE6A39E1D0BB4B5" modified="2018-01-31" version="1">MRRRLINSTLAVVLVVIAVFGISLVIVETRTIESSAQESVQSEAVRLVSIVDSRLVGGERVESGVLREQITPERYARIDIPGRQPIEIGDRPTGGVITATQKGEQGETVMVEESRSTVSREVGRTLLVILAVALLAVIAAVFLAVRQANRLTAPLTDLAETAERLGSGDPRPRHRRYGVPELDRVADVLDGSAERIARMLTAERRLAADASHQLRTPLTALSMRLEEITLTDDPETVKEEATIALTQVERLTDVVQRLLTNSRDPQTGSAVTFDLDEVIKQQIEEWRPATRSGGRALVRSGKQGLRAVGTPGAVSQVLATLIENSLMHGDGTVALRTRVTGNQAVVEVSDEGPGVPVDLGSRVFERTVSGRNSTGLGLAVARDLAEADGGRLELLQQHPPVFALFLSRGADGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ97</accession>
    <name>A0A2G1XJ97_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_14120</name>
        <name evidence="9" type="ORF">CYQ11_13955</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51328">
        <property type="protein sequence ID" value="PHQ51328"/>
        <property type="gene ID" value="BLA24_14120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13848">
        <property type="protein sequence ID" value="PPT13848"/>
        <property type="gene ID" value="CYQ11_13955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758500" description="Phospholipase C" evidence="7">
        <location>
            <begin position="33"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="472" mass="52306" checksum="7D71F9C7A238C29F" modified="2018-01-31" version="1">MTRRRLLGSAVGAAAGAAALSLLPPSVQRAVAAGPARRGSLSDVKHVVMLMQENRSFDHYFGTLKGVRGFADPDALRLPGGRTVFHQPDAENPAGYLLPFHLDTRSSSAQAIPSTSHAWAVQHEAWNGGKMDRWLPAHRKADGKNGPYVMGYHTREDIPFHFALAETFTVCDNYFCSVFGPTWPNRLYWMTGTIDPAGSRGGPVIDNTMPAPYRWTTYAERLQAAGVSWRVYQQTDNYGCNMLEYFRTFRDAKPGSPLYERGMRRLPEGTFEDDARNDRLPAVSWIMPTAGQCEHPDYLPAAGADFIAKKIEAIAANPEVWRKTVFILNYDENDGLFDHVPPPVPPAGTADEFVRGLPIGGGFRVPCVIVSPWTVGGWAAGEAFDHTSALRFLERWTGVREPNISTWRRRTFGDLTSAFGFGEPPSPPPRLPVDTERQLEQAEWEVANLPTPKLPGRAQTVPPQEPGTRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJI1</accession>
    <name>A0A2G1XJI1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_13675</name>
        <name evidence="10" type="ORF">CYQ11_01370</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51386">
        <property type="protein sequence ID" value="PHQ51386"/>
        <property type="gene ID" value="BLA24_13675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11726">
        <property type="protein sequence ID" value="PPT11726"/>
        <property type="gene ID" value="CYQ11_01370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="565" mass="57764" checksum="1D7D4415D2924BC9" modified="2018-01-31" version="1">MERAVTAGEANGAELVGKVLGGRYRVTATIGRGGMGVVARAVDELLGREVAVKILRAYTDASAPDLADLRARMQREAQAAARIRHSGVVTVHDVTEDQGLPVIVMELVDGPSLDDVLTERGTLEPHEAAAIGAKLMDALDAAHRVGVLHRDVKPGNVLLEHGGRVVLTDFGIASMEAAGDDAVTKLTQSGQIIGSIDYLPPERAQGREPGPASDIWSLGMTLYAAVEGASPFRRTSVWSTMTAIVNEPLPEPRRAGPLTPVLRALMAKEPENRPAAAQARQMLEAVAAGGTTPPAPPAPAQPRTPTVAVTPPPPGAGAVPFHQPAHQPQSQPPHAGWPPPGQPHAVTRPGAADAGHAPGGSRSGAAGGRRRGRAVIATTAAAVVLAGGGVTYALVGKDGGTGGGRAQAAAPGVDSPAGSGRPGDAAGTTPSAGAHGKQSGTPSQRPSRTADDGKHHGAGTTAPSASASPAATPSSVSKSCGGWSHQDPKPGTYGYMSGSFHLQTGPYETCPAVSLAKTGTKLWYHCYVVNAHGNKWTYVRVEGTSTSGWMSNDNLTRQNGPSVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJQ8</accession>
    <name>A0A2G1XJQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XshC-Cox1-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_13370</name>
        <name evidence="5" type="ORF">CYQ11_01090</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51494">
        <property type="protein sequence ID" value="PHQ51494"/>
        <property type="gene ID" value="BLA24_13370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11676">
        <property type="protein sequence ID" value="PPT11676"/>
        <property type="gene ID" value="CYQ11_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="118"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="3">
        <location>
            <begin position="206"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="389" mass="40159" checksum="4A37764444BA91AE" modified="2018-01-31" version="1">MLDIAEELARWAAQGRDFAVATVVAVSGSAPRGPGAALAVDGSGQVVGSVSGGCVEAAVYDLCVEALQDGKARRERFGYSDDDAFAVGLTCGGTIEVVAAAFPAAAPGREVLAQALTAAADGEAVALARVVRGPDELLDGILLVRPDGSHEGGLGGRPELDRTAVAEAHALLGAGHTGTVELSQDGAHCPGGVTLLVESGLEPPRMIVFGAVDFTAALVRVGKFLGYHVTVCDARPVFATAARFPEADAVVADWPDRYLRHTATDARTVLCVLTHDAKFDVPLLRVALRLPVAFVGAMGSRRTHDDRVRRLREAGVSDVELTRLRAPIGLDLGGRTPQETALSIAAEIVAARHGATGLPLTATRTAIHHPAPDTPARAGRRLTCPAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJY2</accession>
    <name>A0A2G1XJY2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13620</name>
        <name evidence="2" type="ORF">BLA24_30095</name>
        <name evidence="4" type="ORF">CYQ11_01340</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000166">
        <property type="protein sequence ID" value="PHQ48402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48402">
        <property type="protein sequence ID" value="PHQ48402"/>
        <property type="gene ID" value="BLA24_30095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51537">
        <property type="protein sequence ID" value="PHQ51537"/>
        <property type="gene ID" value="BLA24_13620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16277">
        <property type="protein sequence ID" value="PPT16277"/>
        <property type="gene ID" value="CYQ11_01340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="69"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="298" mass="32165" checksum="155784D7681F4B66" modified="2018-01-31" version="1">MDPELEAFIPLFPKADLTDPVEERKKFAELAASVPAPDTSQLDIEDRTVPADPDVPVRVYRPRQAQGAVVWLHGGGYVMGDLDTEHPWAARIADSSGAVVISVGYRVAPEDRFPAALDDAYAVLAWAAEHAAELGVDPERIAVGGHSAGAGLAAAVALRARDQQGPPIRFQLLNQPGLDDRQETWSARNFTETPWMNRDKVTAIWRHYLGSAPASPYAAPARAADLSGLPPAYVTTAEFCPNRDEGIDYALRLLQAGVPVELHQWSGTFHGSQAILSAEVSQRQIAELSAALHRALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJY5</accession>
    <name>A0A2G1XJY5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12685</name>
        <name evidence="2" type="ORF">CYQ11_17040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51555">
        <property type="protein sequence ID" value="PHQ51555"/>
        <property type="gene ID" value="BLA24_12685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14345">
        <property type="protein sequence ID" value="PPT14345"/>
        <property type="gene ID" value="CYQ11_17040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="51734" checksum="F5CD73D8F6AA086B" modified="2018-01-31" version="1">MLDPLATVTEAFTSFLFGKVETTRLPVRTSTGQAQAVYLPTAAPGLGDSGVIIGREVYSGKGYIYDPFQLYGQQLPAPHWLVLGESGNGKSALEKTYVLRQLRFRDRQVVVLDAQGEDGVGEWNLIAQQLGITPIRLDPMAALDGGIRLNPLDPAITTTGQLALLRTIIEVATGRGLDERAGFALKVAHAYVNETILDRQPVLTDIVEQLRHPEAESAESMNVDIDDVRAWGLDVALVLDRLVDGDLRGMFDGPTTAGIDLDAPLIVFDLSHIDRNSIAMPILMAIVGVWLEHTWIRPDRKKRIFLVEEAWHIINSPFVAQLFQRLLKFGRRLGLSFVAVVHHLSDVVDGAAAKEAAAILKMASTRTIYAQKADEARATGRVLGLPRWAVEIIPTLTPGIAVWDVNGNVQVVKHLITDAERPLVYTDRAMTEDGDRTHELAAEAAAAERAAAAMEAHAAYEGSYGTYGSTEPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK21</accession>
    <name>A0A2G1XK21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_12870</name>
        <name evidence="10" type="ORF">CYQ11_17225</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51585">
        <property type="protein sequence ID" value="PHQ51585"/>
        <property type="gene ID" value="BLA24_12870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14377">
        <property type="protein sequence ID" value="PPT14377"/>
        <property type="gene ID" value="CYQ11_17225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="37100" checksum="A5830AFC0A0371DA" modified="2018-01-31" version="1">MATDFAAVSRRTPGSAPGPGTPSGRLSLPPLLAGLTAALLLSLLCCVALGSSGVGWGETLRYLRAGLTGGTIAPDEVSAYTIVWELRLPRALLAAVVGAGLSALGVATQAMVRNALADPFVLGISSGAAVGANAVLLFGALGSLGVWALSSAAFASALAAMTLVYAAARTERGLTPLRLVLTGSAMYYGFSAVTTLMVFSADRGEAARSAMMWLLGSLGGATWASVPIAAGVVLAGLGALLWSARSLNALAMGDETATALGVDPERTRRVLFVVTAAVTGAVVAVSGAIGFVGLMVPHATRMLVGADHRRLLAVAPLLGAVLLVWVDVVSRLLLAPVELPVGVITALIGVPCFVLLMRRRGYVFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK34</accession>
    <name>A0A2G1XK34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12905</name>
        <name evidence="4" type="ORF">CYQ11_17265</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51592">
        <property type="protein sequence ID" value="PHQ51592"/>
        <property type="gene ID" value="BLA24_12905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14385">
        <property type="protein sequence ID" value="PPT14385"/>
        <property type="gene ID" value="CYQ11_17265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="487" mass="50413" checksum="E3619CDA28AD7747" modified="2018-01-31" version="1">MSDQHHHNPYQRQEPYPSYEPYGPYDAYDPQTDPAPQQGTVPPSYDYGYDQSQGGHTGHDRAPASPAWPQHDHAAQQDPPTQTWQTQTWDTGTWQQPAAPAPEPSYGSPWQTGDQGGDQGGHRGAGQTDAGTGGWAQQPRHAQPHQQQPRHAQPQHAQPHQQQPQHAQPRHAQPQQQFHQQQAADVYPPQTADAYQPAHASLPETSPYGADPADRAPAHEPAGEPGAPAEPAPDRPLTAAEKAKAEGRAQIVSPGFQPALVTSVLAALLAVTAPLGRPALAVPVVLLQAVTAAGWFRLNGMWPARQGIALAFLGGVVADAGLLATERTQAPTVLLGTLGVWILLVIVLQLRSHASPDERLYGLTAATASAALAVVAAGHLAADSDAVVVGALGVAVAVLARALPLPSVAGTVVALIAAAGAGVAGGQLTGMGAPAALLGLTAGVCALTGLRVASYDYPSRFVHLTAGVALPLALAAPAVYVLGRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK62</accession>
    <name>A0A2G1XK62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13025</name>
        <name evidence="3" type="ORF">CYQ11_17385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51633">
        <property type="protein sequence ID" value="PHQ51633"/>
        <property type="gene ID" value="BLA24_13025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16623">
        <property type="protein sequence ID" value="PPT16623"/>
        <property type="gene ID" value="CYQ11_17385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="29316" checksum="DF513CCCAFEDA2B8" modified="2018-01-31" version="1">MAARTAPQHRPIGSATRGTTNPNRLRRMDRWIADAHAAALRRAADPVAVDLGYGAAPWTAVELLGRLRTVRADAEVVGVEIDPARVAAAKPYERAGLSFAHGGFEVPLPGGRRPLLIRAANVLRQYDEGEVEEVWARLCGRLAPGGLLVEGTCDEIGRRHVWVALGPEGPRTITFAARLGSLEAPSDLAERLPKALIHRNVPGEPVHAFLRDFDRAWAAFAPYGALSARQRWIRAVASLRADWPLVDGPRRWRQGEVTVRWEALAPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKC6</accession>
    <name>A0A2G1XKC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Strictosidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11300</name>
        <name evidence="4" type="ORF">CYQ11_02535</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51676">
        <property type="protein sequence ID" value="PHQ51676"/>
        <property type="gene ID" value="BLA24_11300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11925">
        <property type="protein sequence ID" value="PPT11925"/>
        <property type="gene ID" value="CYQ11_02535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016844">
        <property type="term" value="F:strictosidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Str_synth" evidence="2">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="339" mass="35906" checksum="8A9B25D0E420BF09" modified="2018-01-31" version="1">MSQRKPALRPVVWQPPPRPARARARYGPDPLPPVRRLPLGASGPEDVRVDAEGRVLTGVSDGRVLGVDPVGGRVRTVADTGGRPLGLCPLPDGRLLVCDAERGLLRVEPGSGRVERLLREVAGTPLGVCSNAVTTADGTVYVSDASRRFPLAHWMGDLLEHSGTGRLVRWEPATGDAQVVLDGLHFANGVALASDGSFVVVAETGAYRLRRLWLTGPKAGADDVFAANLPGFPDNLSTGPGGLIWVAMAAPRDPVLDLLHRTRPGLRRALWALPSALLPGPRRTAWAIALDADGRVVRDLQRPGRGYHMVTSVCEHAGGLYLGSLVESSLGVVPLEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKW0</accession>
    <name>A0A2G1XKW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12070</name>
        <name evidence="4" type="ORF">CYQ11_03310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51811">
        <property type="protein sequence ID" value="PHQ51811"/>
        <property type="gene ID" value="BLA24_12070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12057">
        <property type="protein sequence ID" value="PPT12057"/>
        <property type="gene ID" value="CYQ11_03310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="103"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="39832" checksum="77DE39CFD22FDC31" modified="2018-01-31" version="1">MYAASTSVSAPPRPLRPQQSGGGPYLDPSHAVGAAFGGGRARRAPGLGAQPLSGRIDLSGPQGAQLRTVISSVHRICPEFNPVQVLRRGGRSVLLVGTTGRSTAVAKCLLDHSPAWTERFRHEIATYRAFVRHRPPVRVPRLIAADPDNGTLVIERMPGRPAAVQRHPVDTVPRADIRAALGAVCRVNLWRPPAGMFDMPLDYGKRIARYHELGLLTDRDMGDLQKLLHGLAHVQGQFCHGDALLSNVLLSPAGPVLVDWDHAGWYLPGYDLATLWAVLGDAPVARRQISQHAQAAGPTSRDAFLVNLMLVLTREIRTYETAVQRAMQEPATPGAADSGEEQRLLLRRLHDDCAMARRAVRAAVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL10</accession>
    <name>A0A2G1XL10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12075</name>
        <name evidence="5" type="ORF">CYQ11_03315</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51861">
        <property type="protein sequence ID" value="PHQ51861"/>
        <property type="gene ID" value="BLA24_12075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16325">
        <property type="protein sequence ID" value="PPT16325"/>
        <property type="gene ID" value="CYQ11_03315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758501" evidence="2">
        <location>
            <begin position="23"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="268"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="644" mass="69239" checksum="7CCD983A0D68F8EC" modified="2018-01-31" version="1">MRAAGALASAALLLPVVTAGPAATAGQRAPGVFQRQVTDAANRYHVPSSVLLGVAYLESRWDGHSGSPSVGGGYGPMHLTDAATALASAPHHSDATEDARGDAARPRPAVRVAAPAPERGALPARLRTLDRAAELTGMSPERLRRDPAANLQGGAALLAAEQKRLGLPLSDDAADWYGAVAAYAGATDRATARTFADDVYEVIRSGQRRRTDAGQDVALPGSPGLAPRTEQVDRLGLGTVAAAGVECPPTVACESIPAPYQQLEGKDYGNHDVENRPASQKVDFIVIHDTEGTWETTIKLIKDPAYVSWNYTIRSGDGHVAQHVQAKDVAWHAGNWYVNSKSVGIEHEGFLAQPDAWYTEEMYRTSARLVRYLAQKLDVPLDRQHILGHDNVPGTTPATIKGMHTDPGPYWDWAHYFELLGRPFRGVGSPFSGMVTISPDYDDHTPVYTGCAKPGEQCAAHGSGAVRLHVAPRDDAPLVRDVGLRPDGSPSTVDVNDTGARASTGQQFAVAGREGGWTAIWYLGQKAWFRNPWWDPTAVGAHGRLVTPKEGLGEIPVYGRAYPEQEAYPEGVPVQAVTPLPYKLQAGQAYVLGQTSPGEYLWAATFEPAGHRVVRGKEVYYEIQFGHRVAFVRASDVSVRDTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL13</accession>
    <name>A0A2G1XL13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10760</name>
        <name evidence="3" type="ORF">CYQ11_00790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51925">
        <property type="protein sequence ID" value="PHQ51925"/>
        <property type="gene ID" value="BLA24_10760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11630">
        <property type="protein sequence ID" value="PPT11630"/>
        <property type="gene ID" value="CYQ11_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="245" mass="26003" checksum="0020BAB2FF0874F8" modified="2018-01-31" version="1">MTTITTRTVEYPADGLTMIGHLALPAGVGRRSAVLLGPEGMGLSDVERRRADALAELGYVALAFDLHGGRYLGSPEEMLDRCMPLLADPDRMRGIGHAALDVLRTEPRTDPDRIAAIGYGTGGAIALELGRGGVNLRAIGTVNATTTGRPGEAARIRCPVWAGVGSEDPIMPPAQRNAFTAEMQAAGIDWRLTVYGGALHAFHHPPVDHPTVPGVGYHPQHAQRAWRDVVDLLAECLPVTEDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL16</accession>
    <name>A0A2G1XL16_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10730</name>
        <name evidence="3" type="ORF">CYQ11_00820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51920">
        <property type="protein sequence ID" value="PHQ51920"/>
        <property type="gene ID" value="BLA24_10730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11635">
        <property type="protein sequence ID" value="PPT11635"/>
        <property type="gene ID" value="CYQ11_00820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="16623" checksum="213726FFB8DC80DC" modified="2018-01-31" version="1">MQSTMIRRAVEQDAEPLTALVQGADAYRGQYTSIISGYRVTADYIDRHQVFTAVDPTGRLLGFYALVLDPPELDLIFVADDAQGMGVGRLLVEHMMGQAREAGLADVRVVSHPPAEKFYRRLGAERVGTVAPVPPKVMWERPELRFAVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL44</accession>
    <name>A0A2G1XL44_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_10910</name>
        <name evidence="7" type="ORF">CYQ11_00640</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51950">
        <property type="protein sequence ID" value="PHQ51950"/>
        <property type="gene ID" value="BLA24_10910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11606">
        <property type="protein sequence ID" value="PPT11606"/>
        <property type="gene ID" value="CYQ11_00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg" evidence="4">
        <location>
            <begin position="242"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="320" mass="34430" checksum="9FE7377D0C39D84F" modified="2018-01-31" version="1">MLEDVEQGLVQALQIDGRAPFSRVAEVLGVSTQTVIRRYQRLRTEAGLRVVGLADPAQGGRTQWIVRICATPGASEALAQSLARRPDTSWVKLTSAGTEIFAIVQAPQGVHPPVLHKLPRTRGITTVSAHCLLHTYLGGPTAWRGRTQALTPSQQRLLQPALPEEVRSAPLTDADHILIDALGHDGRTSYADLARATGSTQATVARRLNALRACRRLFFDVEVDAAAYGITTQALLWMAVPPAHLEHVANTLAAHDELAAVVATTGPTNLLAQALCATPTDLHRYLTRRLGALPQIQTLETAPVLRTFKAAGHLNARPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLH6</accession>
    <name>A0A2G1XLH6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09215</name>
        <name evidence="4" type="ORF">CYQ11_27825</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52093">
        <property type="protein sequence ID" value="PHQ52093"/>
        <property type="gene ID" value="BLA24_09215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16173">
        <property type="protein sequence ID" value="PPT16173"/>
        <property type="gene ID" value="CYQ11_27825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="214" mass="23868" checksum="C98BF695F632A66D" modified="2018-01-31" version="1">METSQRDEQQRAAEQRRRELLEAADRVVLREGPGASMNAIAAEAGITKPILYRHFGDKGGLYRALAARHTDALLAGLRAALDSPVARRERVEATLDNYLTAIEARPQVYRFLMHPADEGQPSEQGFDVGRHSAPLMRRMGEELAVVITERVDLGPDGEDLARAWGHGIVGMMHAAGDWWLRERPFSREQLVRHLTDLLWGRLAVSGDRLDGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLT6</accession>
    <name>A0A2G1XLT6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09485</name>
        <name evidence="3" type="ORF">CYQ11_28095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52141">
        <property type="protein sequence ID" value="PHQ52141"/>
        <property type="gene ID" value="BLA24_09485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16221">
        <property type="protein sequence ID" value="PPT16221"/>
        <property type="gene ID" value="CYQ11_28095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="99" mass="10002" checksum="1F31E51BFD774B0D" modified="2018-01-31" version="1">MAEGGAGTPHGPAAKEGSVMGDDTDKSKARAQQLHRVIERLRAGRPAGAGGGTPAAPPADAGADDTRGGPGGPDLRAAVRRRMRELDEEERGGPPGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLV4</accession>
    <name>A0A2G1XLV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09355</name>
        <name evidence="4" type="ORF">CYQ11_27965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52119">
        <property type="protein sequence ID" value="PHQ52119"/>
        <property type="gene ID" value="BLA24_09355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16199">
        <property type="protein sequence ID" value="PPT16199"/>
        <property type="gene ID" value="CYQ11_27965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304783" evidence="1">
        <location>
            <begin position="35"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="71"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="331" mass="34569" checksum="B3CABC32F1B8192B" modified="2018-01-31" version="1">MTSSHRPLLSGPRRAAQVLAAAGAAALLLTGCGADSDAGSGEAKDGAGSGGTRTVKDATGTAVKVPANPKRIVTLTQEDLDAVLALGLKPVGITNGQGLNKPPAYLADKVEGVNVVGNLLQPVMDKVIAAKPDLILAGDMQDQQVLKQLREITPATLVTMAPTDDWKISFRGIGNAVNGLDKANKVIADYEAKAKSAGEGLGENKGAEVGIVRWNPEGPSWMEKRQFASGVALDMGLKRPKTQDKDGNAHTPSLSLEKINEIDGDWLFLSTLTSDGEKALKDVQEKPAYKELNAVKKNHAVTVDGSVWSTRGGPLASQAVIDDIVKALKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY6</accession>
    <name>A0A2G1XLY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09535</name>
        <name evidence="4" type="ORF">CYQ11_28145</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52149">
        <property type="protein sequence ID" value="PHQ52149"/>
        <property type="gene ID" value="BLA24_09535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16230">
        <property type="protein sequence ID" value="PPT16230"/>
        <property type="gene ID" value="CYQ11_28145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="431" mass="43554" checksum="5D1E858C3606E749" modified="2018-01-31" version="1">MSSPTTPARRLPLVLRNRVFGTVWLGQVLTQAAVRMFQVGVSWWLVAYAVDGGRGLASGLFMAVSTLPAVALAPVVARTVARVNHRTVLRAAAGTAAAAATALAAWAYASDLPLAAAYAATLALAGCQAFFDPCLTTSVPELVDDEDIEAATGFELSTQSLASLGGALLGALIVDGAGIAGLAVGCASAYLAAALLLATVRFRSQAAPDAAGEDGSGTPPRRTLRQILAGLPFVRRILICFTAANLFTTAVFVVIPLYTKSVLHDGGGTVALLEASLGTGTLIGSFTGARVPGRPTVLGSYLLGAMAVALAVPGLAAGRPVMAGSLVVAGWCVGVIGVRFVALFQRLVPTADKPGFFAVMQAVLGATFPVASLLFGLLGDHLSAQTLCLVQAAGLLPAALALALLRTGSDSAGPEEQPSGAEPLVATGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XML2</accession>
    <name>A0A2G1XML2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52456">
        <property type="protein sequence ID" value="PHQ52456"/>
        <property type="gene ID" value="BLA24_06630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="350" mass="38190" checksum="7268D409EFC298EF" modified="2018-01-31" version="1">MGSHTLISVKCLIRRRPGGSSGGDVVTVTEPEHQLTALLPLDALLTADSPRTAGEDPQHVRSLARLDVPLPPIVVHRATMRVVDGMHRLRAARLRGDERIAVRFFEGTAEDAFVYAVRANNQHGTPLTQADRSAAAERIIRSHPQWSDRLIASAVGLAASTVASLRRRAAGRVGQVTARTGRDGRVRPLNAAEGRRRACALIAARPQASLREIADVAGIAVGTARDVRMRLRKGQDPVPKKLRDDEMRQRAATQPAPVPAPADRPEGVPPAGTPSTEPPLPKLRKDPSLRFSESGRTLLQLLSVHAMGGERWRRLLESVPAHRRTTVAQAARHCAESWLRFAIELERRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMP2</accession>
    <name>A0A2G1XMP2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Cytochrome P450</fullName>
                <ecNumber evidence="8">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="8">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_06890</name>
        <name evidence="13" type="ORF">CYQ11_27040</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="8"/>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XMP2"/>
    <dbReference type="EnsemblBacteria" id="PHQ52498">
        <property type="protein sequence ID" value="PHQ52498"/>
        <property type="gene ID" value="BLA24_06890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16032">
        <property type="protein sequence ID" value="PPT16032"/>
        <property type="gene ID" value="CYQ11_27040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 8" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="499"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="682"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ52498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT16032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1065" mass="115009" checksum="38553D8DE20286C1" modified="2018-01-31" version="1">MTHVTEAPVAAIPVVDISAVGASDTPLQQIMRLARRHGPVFRRRLHGVDRLFVTSLDLVTELADEERFTKHVGPALENVREFTADGLFTAYNHEANWAKAHDILLPAFALGSMRAYHPAMLRVARRLTGSWDARLAEGGPVDVPEDMTRMTLDTIGLAGFGYDFESFARDEPHPFVGAMVRCLDWSMNKLGRDPDADHSAEDAAFRADAAFLAGVVDDVIAARTATGEQRTDDLLGLMLGAPHPADGTTLDAANIRNQVITFLIAGHETTSGALSFALHHLLKDPVALRLAQRETDELWGDAEDPEPTFEDIGRLRWIRQVLNEALRLWPTAAAFAREAREDTLLGGRYPLRAGEGVTVLTPLLHRDPVWGDNPELFDPTRFAPEAEAARSPHAYKPFGTGERACIGRQFALHEATMLLGLLVHRYRFLDTTDYRLRVKETLTLKPDGFTLSLARRTAADRLALRTALRGPRPVTTDDRTPAADGSAALPARARQGTGLLVLHGSAYGTCRDLARDLADEAARLGFDATVAALDERVGALPHETPVVIVAASYNGRPTDDATDFAAWAEHTAAPGAAEGVHYAVLGVGDRNWAATYQRVPTLLDERLAALGGTRLLPRAAADASGDLTGTVEEFTRALRHALLERYGDPDASAEPAEDAADAPAYTVTEVTGGPLDALAARHDVRPMTVTEAHDLTAPGHPRTKRFLRLALPDGVAYRTADHLAVLPANDPALVERAAGLLGVHPDTVLSLHPRRPGRDALPVDRPLTVRELLTHHLELQQRPTARQLAWLADRNPCPPEQAALRAVHADDPRTVLDLIEDHPALRGVLGPAALLELLPPLRPRIYSVSSSPAHSPRHIDLMVSVLAAPARSGRGEFRGTGSNHLAGLRPGDTVWGRVQPCRQSFRIDHQDTAPLLMVAAGTGLAPFRGAVADRHALATAGAGLAPALLYFGCDAPDADFLHEDELRAAERAGAVSLRPAFSERPGESGPFVQHRIAAEGDEVWSLLEAGARVYVCGDGSRMAPGVRAALRDLCSRRTGVDAAGADAWLRRLTDAGRYVEDVYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMV3</accession>
    <name>A0A2G1XMV3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="11" type="ORF">BLA24_07355</name>
        <name evidence="12" type="ORF">CYQ11_27510</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52577">
        <property type="protein sequence ID" value="PHQ52577"/>
        <property type="gene ID" value="BLA24_07355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16115">
        <property type="protein sequence ID" value="PPT16115"/>
        <property type="gene ID" value="CYQ11_27510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="53"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="24326" checksum="1C03047414770CE6" modified="2018-01-31" version="1">MAARPLTEIVESGWAKALDPVAGRIAAMGDFLRAEIAAGRTYLPSGANVLRAFQQPFDEVRVLIVGQDPYPTPGHAVGLSFSVAPEVRPLPGSLENIYREMQTDLGLPRPSNGDLTPWTRQGVLLLNRALTTAPRKPAAHRGKGWEEVTEQAIRALVERGGPMVAVLWGRDARNLRPLLGGVPCVESAHPSPMSADRGFFGSRPFSRANDLLTRQGAAPVNWQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMZ7</accession>
    <name>A0A2G1XMZ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent monooxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06850</name>
        <name evidence="4" type="ORF">CYQ11_27000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52617">
        <property type="protein sequence ID" value="PHQ52617"/>
        <property type="gene ID" value="BLA24_06850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16827">
        <property type="protein sequence ID" value="PPT16827"/>
        <property type="gene ID" value="CYQ11_27000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="41677" checksum="0DCD24FCA689E5F0" modified="2018-01-31" version="1">MAHALIIGGGIAGPVTAMALQRAGIGSTVYEAYPSGADHAGAFLVLFANGLEALAVIDADRTVHDRSFPSGTVEFLSDTGGTLGTRPLAGSAGGPRPRTLPRSALYRALRDEATRRGIPVEYGKRLVATGTGPRGTVTALFADGSRAEGDLVVGADGIHSRTRTLLDPTAPRPRHTGQLTVCGRTRDTGHPAPPDTYRMMYGRRGFFGCATAPDGTTYWFANIPGPEVPKTALAAHTPDQWRRRVTETFADDRTPAAAIAAATGRDIVGMNVYDLLSTPVWHDHHTVLVGDAAHATAPNAAQGASMAIEDGVVLARCLRDLPAPDRAFAAYERLRRERVERVVAMSAALAGRAARTAEERRARDAEVAARTAGNTGGGTDWLTGYRVDWDAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN85</accession>
    <name>A0A2G1XN85_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06175</name>
        <name evidence="2" type="ORF">CYQ11_03700</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52688">
        <property type="protein sequence ID" value="PHQ52688"/>
        <property type="gene ID" value="BLA24_06175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12122">
        <property type="protein sequence ID" value="PPT12122"/>
        <property type="gene ID" value="CYQ11_03700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="34520" checksum="90ED83AF3BB0930B" modified="2018-01-31" version="1">MTATEPRREWYDRAGVRTDPRRLLAGELQEGCLYFPPALVPYLGHPLVRALPAPRRDALLARHLFHYLGFTAQFETRVVNRATERIAGGRCDIELPVATRLDAYRIYVDEGYHSLYSLDVVDQVSRASGVAVAPYDFAPFLARLDDVGHRALPDEPVLAQLLQVVVFETLITAILNDVPKDRRVLTVVRDIVRDHARDEGWHHAFFLGFFRELWAGQPAARRGRIARCLPGLIRSSLLPDLGPVRASLAAAGLPPAAVEEVVRDSYPPQRVNADVRSASRHAVRLFEETGVLDVPGGRAAFETAELVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNF5</accession>
    <name>A0A2G1XNF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_05810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52777">
        <property type="protein sequence ID" value="PHQ52777"/>
        <property type="gene ID" value="BLA24_05810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="14"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="484" mass="49052" checksum="24A9F94AA288901E" modified="2018-01-31" version="1">MDHTTALLIELGVIILGLGLLGRLAGRMGFSPIPLYLLAGLAFGNGGVRPLSASAGFVSAGADIGVILLLLLLGLEYSASELVTDLLTQYPSGAVDLVLNAVPGAVAAWLLGWGAVAAVALAGVTWVSSSGVIAKVLSDFGRVGDRETSAVLGVLVIEDLAMAVYLPLLTTLLAGLSPAAGGLALVTSLGTVAFALYVALRHGHLISRAVSCDNPEMLLLVVLGMTLFVAGVTQRLHVSAAVGAFLIGIALSDEVAEGARDLLSPLRDLFAAVFFVFFGLSTAPAAIPPVLAPALLLAAVTVVTKIATGWYAARRAGAPPAGRWRAGGALVARGEFSIVIAGLSAGVAPGLAPLATAYVVIMVTLGPLTARWTEPLARRLRRRAPEPPPPRAAPSRPATPAPPRARAEDGHRRGGPTPDGRPSCPVGVGNDDRPGRLSGARRATDGYGTTLSSLFGVPAPGPVTLSAVAPWVSAPATCSGVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH6</accession>
    <name>A0A2G1XNH6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52699">
        <property type="protein sequence ID" value="PHQ52699"/>
        <property type="gene ID" value="BLA24_05310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="94" mass="9824" checksum="69FDE13BF01497E3" modified="2018-01-31" version="1" fragment="single">MSTREQPSPSDPDDDRPRPGKAAGRPRGGTVPPQSRTGEDGRTADGDGDPPSSVGRLAATVERLRRQVTAAHAAADGRALVELAKGVLVERLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNI6</accession>
    <name>A0A2G1XNI6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05500</name>
        <name evidence="4" type="ORF">CYQ11_01960</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52815">
        <property type="protein sequence ID" value="PHQ52815"/>
        <property type="gene ID" value="BLA24_05500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16294">
        <property type="protein sequence ID" value="PPT16294"/>
        <property type="gene ID" value="CYQ11_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="18561" checksum="B2DD83E65863F959" modified="2018-01-31" version="1">MDRSAPQAPVAPGSDVRPVVRVPVALRVNGTERRLEVDTRTTLLDALRDGLKLTGTKKGCDQGQCGACTVHVDGRRVLSCLTLAASADGREVLTIEGLGRDGAPHPVQEAFVRHDGLQCGYCTPGQIMSAVALIQEGRAGSDDDIREFMSGNLCRCGAYPNIVAAIRQAAGRGDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNJ3</accession>
    <name>A0A2G1XNJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05405</name>
        <name evidence="3" type="ORF">CYQ11_01865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52814">
        <property type="protein sequence ID" value="PHQ52814"/>
        <property type="gene ID" value="BLA24_05405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16293">
        <property type="protein sequence ID" value="PPT16293"/>
        <property type="gene ID" value="CYQ11_01865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="262" mass="28442" checksum="2FB8A4DCA70669F0" modified="2018-01-31" version="1">MPHAKSTDGVRIAYQPRGDGTPLVLLAGQANTHHWWDHVRDDFQAAHRTVTLDYRGTGESDKPDEPYSIEGFAQDVVAVLDDLGVDRAHVYGTSMGGRVAQRLAARYPHRVRALVLGCTSPGGRHAVERGDDVRRALARPGPAAGRALRELMYTPAWLATGTGPRNTLGDPAMPAYARRRHLAASNAHDAWDVLPDISAPTLVVHGTDDLLNPTANAHLLADRIPGARLHLIPGARHAYFEEFRATAGPLVLDFLAEHDHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNJ7</accession>
    <name>A0A2G1XNJ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05880</name>
        <name evidence="3" type="ORF">CYQ11_02355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52790">
        <property type="protein sequence ID" value="PHQ52790"/>
        <property type="gene ID" value="BLA24_05880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11892">
        <property type="protein sequence ID" value="PPT11892"/>
        <property type="gene ID" value="CYQ11_02355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304799" evidence="1">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="40239" checksum="236AB06E226315B6" modified="2018-01-31" version="1">MSRFLFVVPPLTGHINPAAATAAELTARGHRVAWAGWPDLVARLAGAGATTYACALPAGVRRPPELRGVAALRFLWQDFLAPLAEAMAPATERAAADFRPDVLVADQQALAGALVAERLGVRWATSATTSAEFTGAVAGLPKVEEWIHGLLTGLRQRLGDPAATHDPRFSPHLTLAFTVAELAGAPALPEVRYVGPAVPPHPAAAEDFPREWLDPGRSAVLVTLGTVNADTGARFLAECAAAVRERAHRLQAVIADPGDTLGGVRDGDVVALRHVPQLALLPRMSAVVCHAGHNTVTESLWHGLPLVVAPIRDDQPVVAGQVTAAGAGVRVRFGRADRTRLGAALDAVLGERHHRDAALRLRAALRSAGGAATAAGHLEDLAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNL4</accession>
    <name>A0A2G1XNL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04530</name>
        <name evidence="2" type="ORF">CYQ11_28995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52845">
        <property type="protein sequence ID" value="PHQ52845"/>
        <property type="gene ID" value="BLA24_04530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11498">
        <property type="protein sequence ID" value="PPT11498"/>
        <property type="gene ID" value="CYQ11_28995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="73" mass="7913" checksum="4EF9A27787514D92" modified="2018-01-31" version="1">MIVMGGQKKSMERRRRRIPRRHPLADQLNDALTIVVVIIVVAVCSPALSPEALGLIGVVATALGSRARLRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNM1</accession>
    <name>A0A2G1XNM1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">YafY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_05370</name>
        <name evidence="6" type="ORF">CYQ11_01830</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52813">
        <property type="protein sequence ID" value="PHQ52813"/>
        <property type="gene ID" value="BLA24_05370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16292">
        <property type="protein sequence ID" value="PPT16292"/>
        <property type="gene ID" value="CYQ11_01830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="319" mass="34753" checksum="7793AC10AE12D0B2" modified="2018-01-31" version="1">MTSDMTARMLRLLSLLQTRREWSGSDLAERLGVTVRTVRRDIDRLRELGYPVDSARGHAGGYRLAAGADLPPLLVDDDEAVAIAVALRTAAGGLTGIEETTLRALAKLEQVLPRRLRGQVTALQTSLAGITWEPRGPRADPAVLATLAVACRDHEVLTFGYTTRHGTAASRRAEPCHLVVSGGLWYLLAHDTDKDDWRLFRLDRITQPTPTGRRVPRRRVPGDDPAAFVAGRLSAAPTRHRAVATVHASADHVRARTRGLGTRVQPLDEGTCRVDASDDVLPRIAQTLAGLDTDYTLDADADVLEHLRATARRTLRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNM8</accession>
    <name>A0A2G1XNM8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05885</name>
        <name evidence="4" type="ORF">CYQ11_02360</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52791">
        <property type="protein sequence ID" value="PHQ52791"/>
        <property type="gene ID" value="BLA24_05885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11893">
        <property type="protein sequence ID" value="PPT11893"/>
        <property type="gene ID" value="CYQ11_02360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="28437" checksum="37CED908E2044F10" modified="2018-01-31" version="1">MSAVQAGPTRLNVERLGTPGGGETVVLVHGIATDNLTSYYFTLGPRLAAAGHSVVMYDQRGHGRSERPASGYRLERFTADLAALLDTLGLHHPVHLVGNSFGGTVALDYALHHPGRVAGVVLVESEPPTAAWARKMGGLLAGSAYWLRDARTLPWIEETYGRHEARLARWSCRLLHDTTLAADIAASRIPDADRWRSLDVPVLAVYGADSDLAPQGARLAALLPRCRTVTVPGHGHSVLVGSPGTVAALLLDRLGAGHREQPTAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPM9</accession>
    <name>A0A2G1XPM9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02190</name>
        <name evidence="2" type="ORF">CYQ11_04555</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53173">
        <property type="protein sequence ID" value="PHQ53173"/>
        <property type="gene ID" value="BLA24_02190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12265">
        <property type="protein sequence ID" value="PPT12265"/>
        <property type="gene ID" value="CYQ11_04555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="212" mass="22775" checksum="3ECD3D140DBBC32C" modified="2018-01-31" version="1">MIEAVVFDVGETLIRDDRGWQRWADWLGVPRHTLSALVGAVVAQGRDNADALRLARPGVDIGAEYRAREAAGHGEMLDESDLYPDVRPALTAMRDSGLRVIIAGNQTRRAGELLAALDLPAHAVATSGEWGVAKPDPAFFARVIALAGAAPTRIAYVGDHPQNDVVPAAAAGLRTVHIRRGPYGHLWADSPEARTADWRVQSLTELAGLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPN7</accession>
    <name>A0A2G1XPN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_02405</name>
        <name evidence="7" type="ORF">CYQ11_04770</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53207">
        <property type="protein sequence ID" value="PHQ53207"/>
        <property type="gene ID" value="BLA24_02405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12299">
        <property type="protein sequence ID" value="PPT12299"/>
        <property type="gene ID" value="CYQ11_04770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="471" mass="48084" checksum="7148FC3DAC987FE0" modified="2018-01-31" version="1">MGVGVRWTLHGDGRTPAPGAVVRPDERLSWPRTAGLGAQHVVAMFGASFVAPVLMGLDPNLAIMMSGVATILFLLATRGRVPSYLGCSLSFVGVAAIIRAQGGDSAAVTGAILVVGAVLFLSGLAVRRFGAQIIHAAMPPVVTGAVVMLIGFNLAPVTASTYWPQDQWTALLTMLFTGLAVVCLRGFWSRVAIFLGLVFGYAVSWVFDRLFGKIHSVRGGGQAVDHWRLDLSGVGKADWVGLPSLHAPSFGWSAALVALPVVIALIAENAGHVKAVGEMTGDPLDDQLGTAIAADGAATVLSTAVGGPANTTYSENIGVMAATRVYSTAAYWAAAGFALLFGLCPKFGAVVAAIPGGVLGGITVILYGMIGLLGAQIWVHNNVDLRNPLNLVPVAAGVIIGVGGVSLKISANFELSGIALGTIVVITGYHALRALAPAHLKEQEPLLDAGTSGYDDDAAGGPAAGGATGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPV5</accession>
    <name>A0A2G1XPV5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein BLA24_02900</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02900</name>
        <name evidence="6" type="ORF">CYQ11_05195</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53277">
        <property type="protein sequence ID" value="PHQ53277"/>
        <property type="gene ID" value="BLA24_02900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12372">
        <property type="protein sequence ID" value="PPT12372"/>
        <property type="gene ID" value="CYQ11_05195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="26816" checksum="8D88AEE9923906BE" modified="2018-01-31" version="1">MSGHSKWATTKHKKAVIDAKRGKLFAKLIKNIEVAARMGGVDIEGNPTLYDAIQKAKKQSVPNKNIDSAVKRGGGLEAGGADYETIMYEGYGPNGVAVLIECLTDNRNRAASDVRVAMTRNGGSMADPGSVSYLFNRKGVIIVPKGELTEDDVLGAVLDAGAEEVNDLGENFEVLSEATDLVAVRTALQEAGIDYDSAEANFVPTMQVELDEEAARKIFKLIDALEDSDDVQNVFANFDVSDEVMAKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPX0</accession>
    <name>A0A2G1XPX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HIT domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02960</name>
        <name evidence="6" type="ORF">CYQ11_05260</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53288">
        <property type="protein sequence ID" value="PHQ53288"/>
        <property type="gene ID" value="BLA24_02960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12384">
        <property type="protein sequence ID" value="PPT12384"/>
        <property type="gene ID" value="CYQ11_05260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="49"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="20136" checksum="2BB2D67D71B50CFB" modified="2018-01-31" version="1">MLLSMTSEPEQQFGVGAPDAFQRLWTPHRMAYIQGEGKPTGPGADDGCPFCSIPAKSDEDGLIVARGELVYAVLNLYPYNGGHLMVVPFRHVADYTELDEAETVELAAYTKRAMRALREASGAHGFNIGMNQGSVAGAGIAAHLHQHVVPRWGGDTNFLPVIGHTKVLPQLLADTRKMLADVWPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQI2</accession>
    <name>A0A2G1XQI2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ORF">BLA24_00525</name>
        <name evidence="11" type="ORF">CYQ11_07535</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53451">
        <property type="protein sequence ID" value="PHQ53451"/>
        <property type="gene ID" value="BLA24_00525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12756">
        <property type="protein sequence ID" value="PPT12756"/>
        <property type="gene ID" value="CYQ11_07535"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="28271" checksum="ABE3715BF65B6CF4" modified="2018-01-31" version="1">MSVLDEIIDGVRADLAERQARVSLDELKERAAKAPQARDGAAALRGENVSVICEVKRSSPSKGALAAIADPAGLAADYEAGGAAVISVLTEQRRFGGSLADLEAVRAKVDIPILRKDFIVTAYQLWEARAYGADLALLIVAALEQEALVSLIERAESIGLTPLVEVHDEEEVQRAVDAGARIIGVNARNLKTLEVDRDTFARVAPEIPDGIVKIAESGVRGPHDLIAYANEGADAVLVGESLVTGRDPKGAVADLVAAGAHPALRHGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQT2</accession>
    <name>A0A2G1XQT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00010</name>
        <name evidence="2" type="ORF">BLA24_21485</name>
        <name evidence="4" type="ORF">CYQ11_09300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000001">
        <property type="protein sequence ID" value="PHQ53598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50154">
        <property type="protein sequence ID" value="PHQ50154"/>
        <property type="gene ID" value="BLA24_21485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53598">
        <property type="protein sequence ID" value="PHQ53598"/>
        <property type="gene ID" value="BLA24_00010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13062">
        <property type="protein sequence ID" value="PPT13062"/>
        <property type="gene ID" value="CYQ11_09300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="16662" checksum="DD62FDECE7D6685B" modified="2018-01-31" version="1">MRPPRTALVPARDVLALRHAVLRPGLPAEAAAFPEDAAPATFHVAAHDAQGRVRACATFLPQPLPDTGEEAYRLRGMASDPAVRGLGYGVAVLRAGLAEAAARGACLVWCNGRSGARGFYERQGFEVRGEEFLVEGVGPHFVCAIKLPAAGGGGDVRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X998</accession>
    <name>A0A2G1X998_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_30290</name>
        <name evidence="9" type="ORF">CYQ11_23385</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47804">
        <property type="protein sequence ID" value="PHQ47804"/>
        <property type="gene ID" value="BLA24_30290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15429">
        <property type="protein sequence ID" value="PPT15429"/>
        <property type="gene ID" value="CYQ11_23385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="22964" checksum="EF743F5BAB997572" modified="2018-01-31" version="1">MNVLSDNFAMFREGFLGTVELTVLSGLLALVLGTLVAAFRVSPVPALRIFGTTWVTLLRNTPLVLLFLAVTLGLPALGLKGWDSFWLAVLALGCYTSAFICEAVRSGINTVPVGQAEAARSLGMTFTQTLGQVVLPQAARTAIPPIGSLLIALAKNTAIASGFNVSELGSVQKTLNAASGYNIYVIFLWIAVCYIIITFAISGLFRLLENRLAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9E8</accession>
    <name>A0A2G1X9E8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BLA24_30530</name>
        <name evidence="17" type="ORF">CYQ11_23625</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47850">
        <property type="protein sequence ID" value="PHQ47850"/>
        <property type="gene ID" value="BLA24_30530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15475">
        <property type="protein sequence ID" value="PPT15475"/>
        <property type="gene ID" value="CYQ11_23625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="335"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="526"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ47850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT15475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="572" mass="60046" checksum="D955FFC970BDA204" modified="2018-01-31" version="1">MRPRWPRRVSAHVLSVQLVITTGVTALATGLFLEPLGAQLDDQAEHRALAIAQATAAQPGIAHAVLAGPPDPEGPVQAAAERIRLATDASYVVVVDTRGIRYSHTTPAEIGRHVSTDPGQALGGREWTGIESGTLGRSARGKVPLRDGEGAIVGAVSVGIAYGDVRDLLLHALPGILVGAGAALAAGALAAFALSWRLRKRTHGIELSEISALLDEREAMLHGIREGVVALDRRGRVRLVNDAARRLLGLGPDVVGQPLEAVLPPGRTTEVLTGRVAGQDLLIVSGGRVLVANRMDTADGGTVATLRDRTELEQLGRELDGTRGLTEALRAQDHEHANRLHTLLGLLELGMYEEAVDFVAEVTGAHRATAEQVTERVQEPLVSALLVGKSAVAAERGVALRVSAGTRLPERVVDPRDLVTVLGNLVDNALDAAGPCPGPFVEVELRAVGATVVLTVADNGPGVPEEVRELVFADGWSTKEPAPHRPRGLGLSLVRRLAERYGGSARVGERPGGGAVFTVELPEALRTEELGGRGPDGEALLREARDPEGSRPGAPGPEEPSRAPRPLEGVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9J8</accession>
    <name>A0A2G1X9J8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30850</name>
        <name evidence="2" type="ORF">CYQ11_23950</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47903">
        <property type="protein sequence ID" value="PHQ47903"/>
        <property type="gene ID" value="BLA24_30850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15528">
        <property type="protein sequence ID" value="PPT15528"/>
        <property type="gene ID" value="CYQ11_23950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="102" mass="11358" checksum="B879E9099687E04A" modified="2018-01-31" version="1">MRPSTTELDAMVEEAIVDAYDEYDQLTAFHAVIEDHLALPFDTTVLGVAATVTAIELRPGHGLVALCRRGRYRQAIGVLDLPRPEPAPEGWAWVEAYRHWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9S7</accession>
    <name>A0A2G1X9S7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="13" type="ORF">BLA24_31555</name>
        <name evidence="14" type="ORF">CYQ11_24605</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47994">
        <property type="protein sequence ID" value="PHQ47994"/>
        <property type="gene ID" value="BLA24_31555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15620">
        <property type="protein sequence ID" value="PPT15620"/>
        <property type="gene ID" value="CYQ11_24605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="38296" checksum="A91A45A058347514" modified="2018-01-31" version="1">MSERSHQQTGRTAAHDSAFLRACRREPVPHTPVWFMRQAGRSLPEYRKVREGVPMLESCMRPDLVTEITLQPVRRHGVDAAIFFSDIVVPLKAIGVDLDIKPGVGPVVAEPVRTRADLERLRPLDPSDVPYVTEAVGMLTAELGATPLIGFAGAPFTLASYLIEGGPSRTYENTKAMMYGDPQLWADLVDRLADITAAFLRVQIEAGASAVQLFDSWAGALAPADYRRYVMPASTKVFQAVAGYGVPRIHFGVGTGELLGLMGEAGADVVGVDWRVPLDEAARRVGPGKALQGNLDPAVLFAPREAVEAKAREVLDAARGLEGHVFNLGHGVMPSMDPDALTRLVAYVHEQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9V2</accession>
    <name>A0A2G1X9V2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3000 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31550</name>
        <name evidence="3" type="ORF">CYQ11_24600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47993">
        <property type="protein sequence ID" value="PHQ47993"/>
        <property type="gene ID" value="BLA24_31550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15619">
        <property type="protein sequence ID" value="PPT15619"/>
        <property type="gene ID" value="CYQ11_24600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="218" mass="23054" checksum="26A9A6C2C754A519" modified="2018-01-31" version="1">MAAAQGHLSDGPDDAGGEDTPSVFRQAVAGLQGVRLRPEIELDATPPPQRLAPYSYALEAAVVVDDEELADGRLILLHDPAGHEAWGGTFRLVTLVHAELEPEMAADPLLPEVCWTWLTGALEARRVPYAAPSGTVTRASSHYFGGLREREPSTRIEIRASWSPVLPTGSAGQGAVPDTAAHLSAWCDLLCQIAGLPPGGAPEAGIVTLPQRRGPHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9V4</accession>
    <name>A0A2G1X9V4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein ZapE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_31625</name>
        <name evidence="5" type="ORF">CYQ11_24680</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48006">
        <property type="protein sequence ID" value="PHQ48006"/>
        <property type="gene ID" value="BLA24_31625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15632">
        <property type="protein sequence ID" value="PPT15632"/>
        <property type="gene ID" value="CYQ11_24680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="39335" checksum="F60F45B152EB73B6" modified="2018-01-31" version="1">MSSTIASPSSATGSAPVTGQGTDRPVALTSRAPHVPADRLVAEMVPPPRFDTVRFDNYIPDPNQPSQTEAVKLLSGFADGLGDSAAGGRKRWFRSRPAAAAGPRGIYLDGGYGVGKTHLLASLWHATPAPPERKAFGTFVELTNLVGALGFQQTVRTLSGHKLLCIDEFELDDPGDTVLVSTLLGKLVDAGVALAATSNTLPGKLGEGRFAAADFLREIQGLSAHFRPLRIDGEDYRHRGLPQAPAPYDDATVERVAHTTQGASLDGFPALLDHLSKVHPSRYGAMCDGVRAVCLTGVEPVPDQSTALRLVVLADRLYDREVPVLASGRPFDELFSEEMLKGGYRKKYFRAISRLTALARDGKPLTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Y7</accession>
    <name>A0A2G1X9Y7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ORF">BLA24_31770</name>
        <name evidence="6" type="ORF">CYQ11_24825</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48033">
        <property type="protein sequence ID" value="PHQ48033"/>
        <property type="gene ID" value="BLA24_31770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15659">
        <property type="protein sequence ID" value="PPT15659"/>
        <property type="gene ID" value="CYQ11_24825"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="40"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="227" mass="24832" checksum="A18151DE8268CE81" modified="2018-01-31" version="1">MTDLERLAERAGRELEDAPATDILRWAAETFGERLCVTSSMEDAVVAHLASRAVPGIDVVFLDTGYHFPETLGTRDAVAAVMDVRLVTLTPRQSVAEQDAEYGPALHDRDPDLCCALRKVRPLDEGLASYDAWATGLRRDESPARAGTPVVGWDARRRKVKVSPIARWTQDDVDAYVTEHGVLTNPLLMEGYTSIGCAPCTRAVREGEDTRAGRWAGRAKTECGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA48</accession>
    <name>A0A2G1XA48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32285</name>
        <name evidence="3" type="ORF">CYQ11_25340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48117">
        <property type="protein sequence ID" value="PHQ48117"/>
        <property type="gene ID" value="BLA24_32285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15742">
        <property type="protein sequence ID" value="PPT15742"/>
        <property type="gene ID" value="CYQ11_25340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="14359" checksum="7B68F824A4603DBB" modified="2018-01-31" version="1">MRNVSKTNAKDERRPAGELEAGVLAALWAADRPLTPAEVQAGLTHDPARTTVTTTLTRLYEKGIVDRRRQGRGYAYFPVQDAPGLRALRMHSELDRDEDREMVLARFVEGLSPDDERLLRDLLESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC2</accession>
    <name>A0A2G1XAC2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32680</name>
        <name evidence="3" type="ORF">CYQ11_25730</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48180">
        <property type="protein sequence ID" value="PHQ48180"/>
        <property type="gene ID" value="BLA24_32680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15806">
        <property type="protein sequence ID" value="PPT15806"/>
        <property type="gene ID" value="CYQ11_25730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="95"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="334" mass="37364" checksum="95B4DCD03080E726" modified="2018-01-31" version="1">MTEQTERPLAEPRPLGEVRSWPRSFTDRLTAPLPGVRALARLAREGRLRPGAQALRDVPELPVEPARLPAVDAGSLAVTWAGHASWVLRIGGLTVLTDPVWSRRILGTPPRVTPVGVPWEELPPVDAVVISHNHYDHLDLPTLRRLPPDTHLLLPAGLARWARRRRFTRVTELDWWEAVELPGPAGPVRFDFVPAHHWSKRTLTDTCRSLWGGWVITAPGGRRVYFAGDTGYGHWFERIGERYGDIDVAMLPIGAYDPRWMLGPVHTDPEEAVRACQDVGARAMAPMHWSTFLLSAEPPLEPLRRVRAAWETTGRPRADLWDLAVGASRVLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAI3</accession>
    <name>A0A2G1XAI3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_33010</name>
        <name evidence="5" type="ORF">CYQ11_26060</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48238">
        <property type="protein sequence ID" value="PHQ48238"/>
        <property type="gene ID" value="BLA24_33010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15865">
        <property type="protein sequence ID" value="PPT15865"/>
        <property type="gene ID" value="CYQ11_26060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045985">
        <property type="entry name" value="DUF5941"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19365">
        <property type="entry name" value="DUF5941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5941" evidence="3">
        <location>
            <begin position="263"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="593" mass="61483" checksum="5CAFDE69845D94B2" modified="2018-01-31" version="1">MSTAILTGTPPAGSALEGELRSLGFTVRTATGADGAATALAAVPAAERVALVDPRFVGHTHALRLALTDPRFPAGAVPGALTAQPEARGALTRALEAAGTAEPDTVGARLEAEGVAVHRPELGVLVAAVPEDEATRAKTRAEVEAVDDEAVRLRSAVKSRDGFFTTFFISPYSRYVARWCARRGLTPNQVTTASLLTALVAAGCAATGTRPGFVAAGVLLIASFVLDCTDGQLARYSLQYSTLGAWLDATFDRAKEYAYYAGLALGAARGGDDVWALALGAMVLQTCRHVVDFAFTEANHDASANTSPTAALSDKLDSVGWTVWARRMIVLPIGERWALIAVLTALTTPRVVFTVLLIGCAFAACYTTAGRVLRSLTRKAKRTDRAAQALADLADSGPLAELAAGSVGRTVPATAYSAPFWALLATASLLVGPLFAGNAGTWRAVLQALVYAVFAGVAVAQPLKGPLDWLVPPVFRAAEYGIILVLAAKSGVSGALPAAFGLVAAVAYHHYDTVYRIRGGTGAPPQWLVRAIGGHEGRVLAVTAAAALWHGQGFTIALTVLATALALVVLGESIRFWVSSGAPAVHDETGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAI5</accession>
    <name>A0A2G1XAI5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32920</name>
        <name evidence="3" type="ORF">CYQ11_25970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48222">
        <property type="protein sequence ID" value="PHQ48222"/>
        <property type="gene ID" value="BLA24_32920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15849">
        <property type="protein sequence ID" value="PPT15849"/>
        <property type="gene ID" value="CYQ11_25970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="247" mass="27324" checksum="B84294FA6F72C747" modified="2018-01-31" version="1">MAAEAGETTESAETTLTVDELAARAGVTVRTVRFYGTRGLLPPPQIGPRRVGRYGPEHLSRLALIEELQHQGLTLAAIERYLRRLPADLSAHDLAIHRALVASWTPDKAEETSRAQLERRAGRPLAEEDVDRLAAMNVLERAGDDDTFRVDPGLLGLGVQLLDVPIALETVLAARTVLIEHARSTARELTRLFHDEVWGPYRERESDPEEVEAMKSLSAHMQPLVVQALVTAFQRSLKQELRATYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAJ6</accession>
    <name>A0A2G1XAJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF475 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_33190</name>
        <name evidence="5" type="ORF">CYQ11_26240</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48264">
        <property type="protein sequence ID" value="PHQ48264"/>
        <property type="gene ID" value="BLA24_33190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15894">
        <property type="protein sequence ID" value="PPT15894"/>
        <property type="gene ID" value="CYQ11_26240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04332">
        <property type="entry name" value="DUF475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="419" mass="45429" checksum="A4F30C3D012C1330" modified="2018-01-31" version="1">MRQGCEASLQASRPVFRKAKYGAGEPRKKRLGGQWLLKTFGWSFAVTALGLAAAVFYGGWAGFGVVAFLSVLEISVSFDNAVVNAGILKKMNAFWQKIFLTVGVLIAVFGMRLVFPVVIVAISARIGPVEAVRLALDDKDTYQQLVTDAHPSIAAFGGMFLLTIFLDFIFEDREIKWLGRLERPLAKLGRVDRLSVCIALIVLLVSSMTFATHARQHGGIHADKAQTVLIAGVAGLITYLIVGGLSGYFENKLEEEEEREHEAEEEARRSGKKVSAVVMAGKAAFFMFLYLEVLDASFSFDGVIGAFAITNDIVLMALGLGIGAMYVRSLTVYLVRQGTLDDYVYLEHGAHYAIGALAVILLVTIQYEIHEVITGLVGVVLIAWAFLSSVRRNRKPAAAEGDEGKDTGPDGKAEVSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAN3</accession>
    <name>A0A2G1XAN3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48271">
        <property type="protein sequence ID" value="PHQ48271"/>
        <property type="gene ID" value="BLA24_33230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="1055" mass="108535" checksum="47B4FAE79353DFAD" modified="2018-01-31" version="1">MAAGAPGVRGRGVPGPGTGAGGGPRRHGRTRPGRSARRLGVGPRPENPLRARRDRVLRRTPSHRRGGALMSDRNEPLLVAPDWGADTLAVVDLTAPEGPEVRFTPVGSNPRAVAVSTDGTRAYVVNHDDGTLSVVDLTVPEHPVLPPVPAGNGPCAVVAGLVDDQVCVASADGKVEVFDKEGQRSGQRLSVGTGPCALAAAPGGGARRVCVIDETDATVTVVDVSQAGTPSVSAAVSVPGVTRAAAVAPGGRFAYVASQGAGTADGRVTVLDLDADGTAVGDPVPVGAEPRALAIGPAGDRLCVANYGSASVTVATVHPNSGRVDTPTAVPADAHPVAVAFAPDGEVIHVVSQTSGILTAIRADTLDHTAVELKGVPAGVVFGPDGHHSYVTDQATGQLTVVRAAPRKTACIPAGEGSKPVNVAVSPDGTWAYAADSVSENVAVLDLSDLAPLAPVPLGAAHKPWDVAIAPDLGFACATSPESSHLLVLTPVQGNKLTGNGEVTVTPVQLAPDALPYGVAVTPDSRYAVTADSGTATVSLVDPKGGTHTIDDDVVGCQQPTGAAVSRDGRTLYVADFASTPDGARGGQIAMLQRPEQGEWQREEVIDATAGQLSGPHELALSPDELRLYVANYGNGTVSVLKRDVVGDPWSHAMTVTKSPTPMKWPNGLALSPDGETLYVSNNTNGHATVEVFDVSTTPAAHRRTIKIVINPDPGRSVNAGLALSLDGHYLYAVDAEHWKPGTGALGTVYGIQLTAEGDQMETVATAPHAHTDRPSALVCRDDRTLYVVNQESPDPREACLAVITLDASRLGVESTEPRPLDKDDLPHSAAISDDGTLYVANFTSRTVTVFGSKVTPVPVGEQGASQPWDVAVTDDGAYAYVTDRTADSLRCVRLSDHQVTSLGVGTDPMGVACAPGGLRAYVANHGSDSISVIGPDDASPGTPKIVATWEHPRIIKPESVSVSADGAWLFVTTENSGELLMLDTRTGTPRFTIPAGERLTGSTPHPQSAKHLVYLADEAGATVSVVDTTTLAPLDTTTPLGFDVRQAVGVPTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAS5</accession>
    <accession>A0A346M2I7</accession>
    <name>A0A2G1XAS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BcmD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bcmD</name>
        <name evidence="2" type="ORF">BLA24_33485</name>
        <name evidence="3" type="ORF">CYQ11_26535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <title>Biosynthesis of biocyclomycin.</title>
            <authorList>
                <person name="Meng S."/>
                <person name="Pan H.-X."/>
                <person name="Tang G.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MG018995">
        <property type="protein sequence ID" value="AXQ04975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48315">
        <property type="protein sequence ID" value="PHQ48315"/>
        <property type="gene ID" value="BLA24_33485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15946">
        <property type="protein sequence ID" value="PPT15946"/>
        <property type="gene ID" value="CYQ11_26535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AXQ04975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="488" mass="53066" checksum="C45BCFDD8E0E517D" modified="2018-01-31" version="1">MTAPAHPPACPVSGRAPFPGVLAHHPGPSPLDGHESAFHEATVVRGTPASEYFRASGISACAEENGGLCTFRMGPRLAVYQITNGPLLDDEDLAPSTDANRELFGDFMGSLPGDHPDRPAKRAAVETTLGNGRFVEELVPHVRRHAAAFLDRAAGREVPLDEFALSLVAQVDSLVPGVLDLTQRPLPDWLASPEYGAVVRGFFDLASDVITNVNPAAMREFDVIVPFVRELLRANADAIAAAPASNVIRRYFALWDLPFSREGVDGLDAAQVKELGTVIVATYDTTALSLLWALAYIETTPAAKREIVAEARGGQPSASPSPLDLAVLEAVRLGGSNPSALWRRTTRPFTLHHEGRSVTVPPGTMMWLDRRQANRDPAVFPHPEGFDPRNIRALFRSGRETVSSLISRGRHEINSFSMVNATRNPRKCPGRLFSVRVQSVLLAELYSRYEVSARGIDLSLKRHAAMPRPARPGTVLFNALPERTKEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAU2</accession>
    <name>A0A2G1XAU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33400</name>
        <name evidence="3" type="ORF">CYQ11_26450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48299">
        <property type="protein sequence ID" value="PHQ48299"/>
        <property type="gene ID" value="BLA24_33400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15930">
        <property type="protein sequence ID" value="PPT15930"/>
        <property type="gene ID" value="CYQ11_26450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="124" mass="13577" checksum="BD7CF472E353835F" modified="2018-01-31" version="1">MNSDTFVHAWANAYNDQDFHRFGELYTDDTTYECGPFGLAFTGRDPFVRHLREYAGAVPDRKFTIERVIADGDAIAVEFGFGGTSAGVHPGLPPAGEPVTARFCSVLQLREGRIASQTDYLGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX3</accession>
    <name>A0A2G1XAX3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32500</name>
        <name evidence="2" type="ORF">CYQ11_25550</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48373">
        <property type="protein sequence ID" value="PHQ48373"/>
        <property type="gene ID" value="BLA24_32500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16799">
        <property type="protein sequence ID" value="PPT16799"/>
        <property type="gene ID" value="CYQ11_25550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="470" mass="49361" checksum="D8073E5A6B087212" modified="2018-01-31" version="1">MLDAVVVGAGPNGLTAAVELARRGLRVEVFEAADAIGGGARTEELTLPGFRHDPCSAVHPLAVRSPAFTAMPLDRHGLEWVHPGLPMAHPFPDGTAAVLSRSVGETAGSLGPRDAGTYRRLLAPFHGRWDALAADFLRTQWDGPPRDPILYARFGLVAGLPAAVLARLFRDEKARGLLAGLAAHGIAPLRTLGTGGMALVFALAAHEGGWPVPRGGSQAIADALGSYLRALGGVIHTGFEVRHLDDLPPARAFVFDTSPTALARIAGLGGTYANVRYGPSVFKIDYALDGPVPWTAEPARRAGTIHIGPTAGEIGEALRAAVEGDDPSVPFLITAQPSLFDPTRAPEGKHTFWVYGHVPNGWEGDATEVIERQIERFAPGFRDLVLARATAGPPQLAARNANYVGGDIATGSVAGLGLLVRPKLARVPYATPHPSVFLCSSATPPGPGVHGMSGHHAARAVWRRLRTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB06</accession>
    <name>A0A2G1XB06_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Segregation/condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29040</name>
        <name evidence="4" type="ORF">CYQ11_06435</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48427">
        <property type="protein sequence ID" value="PHQ48427"/>
        <property type="gene ID" value="BLA24_29040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12577">
        <property type="protein sequence ID" value="PPT12577"/>
        <property type="gene ID" value="CYQ11_06435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="41754" checksum="02CD938674A9AE4D" modified="2018-01-31" version="1">MPPAASSPARRPLGRGPASRPAVPPPAGDDGARGGDPGRREDGGTARATAAGPEADGTAPAADTRPEPPAAGTAEQAAPSEPAALSEAADRAEPAGTPDTPEPAEAPEPADTTGGADAPDGAGTPDDGRFTIHLENFEGPFDLLLQLIAKHKLDVTEVALHKVTDEFMAHIRAMGPEFDLDQTTEFLVVAATLLDLKAARLLPAAEVEDEGDLALLEARDLLFARLLQYRAYKRIAEIFSGRLEDEAHRHPRTVGLEPHHAELLPEVVLGIGAERLAELAARAMRPRPAPQVYVDHIHAPLVSVREQAEVVVARLREAGEATFGRLTADASDTLTVVARFLALLELYRERVVVLDQDEALGALTVRWTGAADASPVVTDEFDREPETEPEEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBC4</accession>
    <name>A0A2G1XBC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyl-gamma-aminobutyrate hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyl-gamma-aminobutyrate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29795</name>
        <name evidence="2" type="ORF">CYQ11_05680</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48544">
        <property type="protein sequence ID" value="PHQ48544"/>
        <property type="gene ID" value="BLA24_29795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12455">
        <property type="protein sequence ID" value="PPT12455"/>
        <property type="gene ID" value="CYQ11_05680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="26661" checksum="C10204E9274353AF" modified="2018-01-31" version="1">MSGNEERTRELDAPEHRPLIGVTTYLTRARWGVAWDLPATLLPAAYPAYVQRAGGLAVMLPPDDPASAAAVLHRLDGLVLAGGEDLDPALYGARPHPRAGTPVPERDRWELALLDVALRRGLPVLGICRGMQLMNVHAGGTLCQHLPDEVGHDRHNPVPGTFTDHTVTPVPGTRTAGLLSGPLAVATQHHQSVDRLGTGLVATAHAEDGTVEALEYPGKPFALAVQWHPEARDDLRLVRGLVRAATREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBP4</accession>
    <name>A0A2G1XBP4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28620</name>
        <name evidence="3" type="ORF">CYQ11_06845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48674">
        <property type="protein sequence ID" value="PHQ48674"/>
        <property type="gene ID" value="BLA24_28620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12645">
        <property type="protein sequence ID" value="PPT12645"/>
        <property type="gene ID" value="CYQ11_06845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="185"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="374" mass="38956" checksum="CB302FC6A0FC20B3" modified="2018-01-31" version="1">MGLRGATATAAATLIGAGAVAVAAGRYAGDAALKPAPGHPPPGEPRIAVHDADAGTVTLTRTPATLRPGTYGLAGRGLRAVVGPVVPDVSHPHHCVVRRLERVHHGTVAPGDHVWLTPQVHAGTPRDALGLDHTDVDVPGELGWLPAWFLPGARDTWVISAHGMGTTREHSMVLMPFLHGLRLPVLVPAYRGDAGAPRTAHGISHFGAREWRDLDAAVRYAVAHGARRVVLHGWSTGATMALLTALDSPESDRVAGVVLDSPLLDWPAALGALAAHRVPAPLIPLAVRAAEGRTGLAPDALLAAADPGRLSVPALVVHGTDDALAAPSRSRELAAARPELITLRTVRGAGHAASWNVDPQGYEESLRRFLVPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBR8</accession>
    <name>A0A2G1XBR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-sulfur cluster assembly factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28490</name>
        <name evidence="3" type="ORF">CYQ11_06980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48655">
        <property type="protein sequence ID" value="PHQ48655"/>
        <property type="gene ID" value="BLA24_28490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12665">
        <property type="protein sequence ID" value="PPT12665"/>
        <property type="gene ID" value="CYQ11_06980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="113" mass="12441" checksum="935A09D7C746E2F1" modified="2018-01-31" version="1">MTDKADVTTTKPATEEEVREALYDVVDPELGIDVVNLGLIYGIHIDDANIATLDMTLTSAACPLTDVIEDQAKSATEGIVNELRINWVWMPPWGPDKITDEGREQLRALGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBS4</accession>
    <name>A0A2G1XBS4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_28590</name>
        <name evidence="8" type="ORF">CYQ11_06875</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48668">
        <property type="protein sequence ID" value="PHQ48668"/>
        <property type="gene ID" value="BLA24_28590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12651">
        <property type="protein sequence ID" value="PPT12651"/>
        <property type="gene ID" value="CYQ11_06875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012804">
        <property type="entry name" value="Cob_chelat_sub_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02442">
        <property type="entry name" value="Cob-chelat-sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="513"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="702" mass="73895" checksum="C856CD6E982EC044" modified="2018-01-31" version="1">MSTPYPFTAIVGMDDLRLALLLTSVSPAVGGVLVRGEKGTAKSTAVRGVATLMPSVAVVDGCRFSCDPVAPDPTCPDGPHTADAAGSARPTRMVELPVGASEDRLVGALDIERALSEGVKAFEPGLLAAAHRGVLYVDEVNLLHDHLIDLLLDAAAMGASYVEREGVSVRHASRFLLVGTMNPEEGELRPQLLDRFGLTVEVAASRDTDERVEVVRRRLAYDEDPAAFAAKWAAEEDALRERIAAARALLPAVRLGDGALRRIAAVCAGFEVDGMRADIVTARTATALAAWAGRTDVTTEDVRQAALLALPHRRRRNPFDAPGLDEDKLDEILRRFEDEEPDPEPDPEPGGPEDGGPGDEDPDGGGPDGGGRPPQDGPRPDGAGGPDVPQQRQDSPAADPAPRQNSSDGVPGSEGEAPEAPAVAAAEPFRTRRFDVPGLGEGADGRRSRARTAHGRTTGARRPRGGALAKLHLAATVQAAAPHQRARGRSGPGLLVRRDDLREAVREGREGNLVLFVVDASGSMAARKRMSAVKGAVLSLLMDAYQRRDKIGMVTFRGSGAEVALPPTSSVEAGAARLEKLPTGGRTPLAEGLLRAHEVLRVERMRDPSRRPLLVVVTDGRATGGPEPLARAARAARLLAGEGTASVVVDCEAGPVRLGLAAELGRELGGPVVTLDELRADSVATLVRGVRTVRNTDNRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC00</accession>
    <name>A0A2G1XC00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_28300</name>
        <name evidence="8" type="ORF">CYQ11_07170</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48725">
        <property type="protein sequence ID" value="PHQ48725"/>
        <property type="gene ID" value="BLA24_28300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16404">
        <property type="protein sequence ID" value="PPT16404"/>
        <property type="gene ID" value="CYQ11_07170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="425" mass="44142" checksum="8761A80A30E39370" modified="2018-01-31" version="1">MFRLAAASMVGTAIEFYDFFTYGTAAALVLGPLFFPTVSPLAGSLAAFGTFGIGFLARPLGSVLFGHIGDRVGRRPVLISSLLLTGLATIAVGLVPTYRSIGVAAPLLLLLLRFLQGLGLGGEWGGAVLLTAEHAPEHRRALWSSFPQVGPALGFLLANGITVTLSAVLSDAQFLSWGWRVPFWGAGALAAVGLLLRSRLTETPVFRTLSETESRASLPLAEVVRGNWRLLLLTAGGLSIGYALFYTVTTWSLAYGTERLGVDRTVILGCIMTAVAASGVATPLVAFFADRFGRRTLCLSGCAAVALWMFPLIGLLRTGRPALMVLGFVIALLAFATAFGVVGAYLPELYEARIRCTGAAVGYNLAGVLGGAVTPLAATALAGRDGPPWGVAVYLVGVALLSMGCFLALPETNPAVKAATGPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC44</accession>
    <name>A0A2G1XC44_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27480</name>
        <name evidence="4" type="ORF">CYQ11_18165</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48813">
        <property type="protein sequence ID" value="PHQ48813"/>
        <property type="gene ID" value="BLA24_27480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14540">
        <property type="protein sequence ID" value="PPT14540"/>
        <property type="gene ID" value="CYQ11_18165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="53"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="304" mass="33007" checksum="4D67287E1397C596" modified="2018-01-31" version="1">MVRRIEVTGSGGVRLAAWEFAEPSRTGGAGGRCGGRSGAGGAGRAGGGGRGGVLLLHGLLGRAVHWADTARWLSGRYRTVALDQRGHGRSDKPVSGPYVREAYVADAEAAVEQLGLAPVTLIGHAMGALTAWQLAARRPDLVRALVICDMRASALGAATQREWSEWFKSWPVPFTTLADVRKWFGEDDPTLERPAPARGDFYAEVMAERADGWRPLFFRRQMLQAREAYAHDAHWEELALVECPTLVVRGLDGALGRAEAQEMVRVLPRGRYAEIPDAGHLAHYDQPDGWRRAAEPFLKAAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCC4</accession>
    <name>A0A2G1XCC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27800</name>
        <name evidence="4" type="ORF">CYQ11_17840</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48868">
        <property type="protein sequence ID" value="PHQ48868"/>
        <property type="gene ID" value="BLA24_27800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14485">
        <property type="protein sequence ID" value="PPT14485"/>
        <property type="gene ID" value="CYQ11_17840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="20025" checksum="CD8F0917A097D17B" modified="2018-01-31" version="1">MGCAEEAEESRKEERRKQVQREQEKAAQKPCQGPKCSNPVGPSRNRSRLYCSEECSRAAEYIRKRARTKPDPVPCRRCGKPVILKFRDGVCRSCQQMQRTVARRVTLQRRIREAHGDAGCFHCAAPLPEGGVIDHLRPISRGGLSTPANMRVVCVPCNTSKKDQLMDEWSPPHLMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCJ4</accession>
    <name>A0A2G1XCJ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27160</name>
        <name evidence="6" type="ORF">CYQ11_18495</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48921">
        <property type="protein sequence ID" value="PHQ48921"/>
        <property type="gene ID" value="BLA24_27160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16652">
        <property type="protein sequence ID" value="PPT16652"/>
        <property type="gene ID" value="CYQ11_18495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="510" mass="55765" checksum="C8D695A2C89EAF6B" modified="2018-01-31" version="1">MPVYDYVVIGGGTAGSVIASRLTEDPGVTVAVIEGGPTDVDREDVLTLRRWLGLLGGELDYDYPTTEQPRGNSHIRHSRARVLGGCSSHNTLISFKPLPGDWDEWAAAGAEGWDAESMDPYFTRLRNNIVAVDEKDRNAIARDFVEAARAATDVPRVEGFNKQPFHEGVGFFDLAYHPENNKRSSASVAYLHPFLDRPNLHLMLETWAHRLELAGTRAKGVHVRTKDGEEVYVEAAREVLVCAGAVDTPRLLLHSGIGPKADLEALGIPVVHDLPGVGENLLDHPESVIVWETDGPIPENSAMDSDAGLFVRRDPASNGPDLMFHFYQIPFTDNPERLGYEKPEHGVSMTPNIPKPRSRGRLYLTSADPAVKPALDFRYFTDEEDYDARTLVDGIRIAREIAKTEPLAGWLKREVCPGPEITSDEEISAYARKVAHTVYHPAGTCRMGADADELAVVDPQLRIRGLDGIRIADASVFPTMPAVNPMIGVLMVGEKCAELLAKAATLGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCJ7</accession>
    <name>A0A2G1XCJ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_27875</name>
        <name evidence="8" type="ORF">CYQ11_17765</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48940">
        <property type="protein sequence ID" value="PHQ48940"/>
        <property type="gene ID" value="BLA24_27875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16630">
        <property type="protein sequence ID" value="PPT16630"/>
        <property type="gene ID" value="CYQ11_17765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="403" mass="40147" checksum="D08549FB9EFB9944" modified="2018-01-31" version="1">MPVAVHVLGLSVFALGTSEFMLSGLLQPIARDMGVSIPQAGLLVSAFAIGMVVGAPLLAAATLRLPRRTTLVVLLAVFGLGQVAGALAPTYGVLFASRVVSALACAGFWAVGAAVAVSLVPVDARARAMAIMIGGLSIANIAGVPAGALLGQHAGWRAAFWAVAALSAVGLAGVLALVPATKPTTGEDAPRLRAELRIYRDRQVWLALVTTALNAAAVFCLFSYLAPLLTETAGLKESWVPTVLALFGVGALIGATIGGRVADAHLFGTMYGGIGASAVVLAALALTADMAVVAVGLALLLGVAAFMTAPALNARMFNLANAAPTLAGATTTAAFNIGNTIGPWLGGLVIAAGWGYPAVAWLGALLAALAVGTTAVASRLHRGPSRVVAGSAGAAVRTPSQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCQ7</accession>
    <name>A0A2G1XCQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MinD/ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22995</name>
        <name evidence="4" type="ORF">CYQ11_23080</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48975">
        <property type="protein sequence ID" value="PHQ48975"/>
        <property type="gene ID" value="BLA24_22995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15380">
        <property type="protein sequence ID" value="PPT15380"/>
        <property type="gene ID" value="CYQ11_23080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="628"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="934" mass="94208" checksum="F4FDA2C21B72C46D" modified="2018-01-31" version="1">MSSDRDELRAAGRTAGEDRPDAEHDLDHEPEHTGEFTIDYTPPAWYTQSAPQTGGPAAAAPPPSGDPLPPAPAAPVTPVASTAAAEPAPAAADTDSGSPAGTGDVQSQATMRFSPAAVRDEVAQHAEDSDKPGEADASAPAPAPSDEAAPTPPPATSPAAPADSWTPAAAPVPLPPLPPDFPPAAPAPGGAAATWPPAAQAPAPAAPYTPHPGAPAAPAAPQGGYGYPAPAAPAPAAAFPVAAPAQASPDARQDDVPVPHSEAGDAASSDAPAAEDGPSASPQETQAKEMTAGETAGATAEAAAQDGGTPADESAPAAAPATATPDTADTPETDAPATAVPPGNSPTPPGGYGYPGPGGAPAPAPAAPQAPAMPPAAPQGGYGYPTPAAPQAGYGYPAPGVPNGYPTATPPAPHAPAAHGGYGYPGPGAPAPQPTPGFPYPAGDQPGALPPAAYPGFPGQQAPAQPVPGQPFPGAPGPYAPHPGAPAPFPGTEGAPQAPQPQQPQPQPGALPPAVHPAQAEAAPAAHPGYPGHAGYPGQPDGAGSPVDPRTGGWPTVTPEQRQRSVHGAPLGYTAAVELSSERLLKGKPKPKKQSAGTRFKFGGKKEEAERQRKLELIRTPVLSCYRIAVISLKGGVGKTTTTTALGSTLASERQDKILAIDANPDAGTLGRRVRRETGATIRDLVQAIPHLNSYMDIRRYTSQAPSGLEIIANDVDPAVSTTFNDEDYRRAIDVLGRQYPIILTDSGTGLLYSAMRGVLDLADQLIIISTPSVDGASSASTTLDWLAAHGYGDLVSRSITVISGVRETGKMIKVEDIVSHFETRCRGVVVVPFDEHLAAGAEVDLDMMRPKTREAYFNLSAMVAEDFVRAQQQQGLYAAPHQAPPVPGAYAPEAVQAGQPAPAPGPYHPYGAGQPQPGPYPQQDGGWPMPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCW9</accession>
    <name>A0A2G1XCW9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23575</name>
        <name evidence="4" type="ORF">CYQ11_22495</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49068">
        <property type="protein sequence ID" value="PHQ49068"/>
        <property type="gene ID" value="BLA24_23575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15286">
        <property type="protein sequence ID" value="PPT15286"/>
        <property type="gene ID" value="CYQ11_22495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="27607" checksum="07D5A992D18C14C7" modified="2018-01-31" version="1">MRIARFSIDGNVAFGVVEGDELDIIKGHPFAEFERSGQKIPLDKVRLLPPVLPNKVVAIGRNYAEHAAELGNEVPEVPVTFFKPSTSVVGPGDPIAYPSFSSELHHEAELAVVIGRMCREVPRERVKDVILGYTCANDLTARDVQQREKQWARAKGFDTSCPLGPWIETGLEPADIAAGLGVQCTVNGDQRQLGSTADMVRPIEDLIVHITEAMTLLPGDVVLTGTPAGVGPLNVGDEVAVTIEGIGTLTNKVIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDK4</accession>
    <name>A0A2G1XDK4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_24625</name>
        <name evidence="11" type="ORF">CYQ11_21445</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49249">
        <property type="protein sequence ID" value="PHQ49249"/>
        <property type="gene ID" value="BLA24_24625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15099">
        <property type="protein sequence ID" value="PPT15099"/>
        <property type="gene ID" value="CYQ11_21445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="141"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="370" mass="39826" checksum="49DF1E8762B7A7F3" modified="2018-01-31" version="1">MTAPPPGDGPSVPGPWHRLWEALRPLDPYRSVKAALGALVIGSVVITTFLVSVAIHSATELRVITIFSIIASLLITQFVAHGLTAPLDEMTEVTRSMAQGDYSRRVRAGRRDEFGDLAHAFNRMAADLEAVDTHRKELVANVSHELRTPIAGLRAVLENVVDGVSAPDPETMRTALRQTERLGRLVEQLLDLSRLDNGVVPLRSRRFEVWPYLAGVLKEASMAVGGAGSPRARNDVHLHLDVSPPELTAHADAERLHQVVANLVDNAVKHSPPHGRVTVRARRGEGAQSLALEVLDEGPGIPESERHRVFERFNRGSSGAQGPVGDGGTGLGLAIARWAVDLHGGSIGVAESPRGCRIKVTLPGRPKDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDV8</accession>
    <name>A0A2G1XDV8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25590</name>
        <name evidence="2" type="ORF">CYQ11_20480</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49417">
        <property type="protein sequence ID" value="PHQ49417"/>
        <property type="gene ID" value="BLA24_25590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14933">
        <property type="protein sequence ID" value="PPT14933"/>
        <property type="gene ID" value="CYQ11_20480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="31790" checksum="6A1D98117797B21E" modified="2018-01-31" version="1">MPPAAPRPRVLYVTDLAYEARGRRYCDEDIYLSSRLREDFDLALCHPLDAAALTETGAFDAVVVRNSGPVLHYQAAYDDFRARAARCGARVYNELTGKADMAGKQYLVDLSAAGHPVIPTADRAEDLTRLPEVAEYVAKPKAGADSIGLRFVPRDDLGALDFEGGVLVQPRVRFRYEVSFYFVDHAFQYALHAPDPERRWALERYEPTAEDLAFAQGFIDWNAVEHGIQRVDACRTPEGELLLVELEDLNPYLSLDLLDEASRDAFVVSVKESLRGLLAAPAAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE73</accession>
    <name>A0A2G1XE73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glyceraldehyde 3-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26245</name>
        <name evidence="4" type="ORF">CYQ11_19395</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49533">
        <property type="protein sequence ID" value="PHQ49533"/>
        <property type="gene ID" value="BLA24_26245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14747">
        <property type="protein sequence ID" value="PPT14747"/>
        <property type="gene ID" value="CYQ11_19395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="34"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="38308" checksum="ABF7084D54BC661E" modified="2018-01-31" version="1">MDMTDPSLYRAAGTRYDSMEYRRTGRSGLKLPAISLGLWHNFGDDRTLDSQRAILRRAFDLGVTHFDLANNYGPPPGSAELNFGKLFAQDFRPYRDELVLSTKAGYLMHPGPYGEWGSRKYLLSSLDASLRRMGVDYVDIFYSHRFDPHTPLEETMGALASAVQQGKALYAGVSSYSAEQTREAARLLREMGVPALIHQPSYSMINRWTEDDALLDALEEEGMGCIAFAPLAQGMLTDKYLDGVPEGSRASRGTSLDPALLTGEVVERLRGLNEIARRRGQSLAQLALTWVLRDERMTSALIGASSVAQLEANVGALGAPALTKDELAEIDALAVSTEGVNIWARRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE82</accession>
    <name>A0A2G1XE82_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26265</name>
        <name evidence="4" type="ORF">CYQ11_19375</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49536">
        <property type="protein sequence ID" value="PHQ49536"/>
        <property type="gene ID" value="BLA24_26265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14744">
        <property type="protein sequence ID" value="PPT14744"/>
        <property type="gene ID" value="CYQ11_19375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="40633" checksum="C0A2D25081EA7F0D" modified="2018-01-31" version="1">MLVGVPPAGAAATRAEGPAAYRVAAGATAVRGAATSSDGPLIRAGTGTYTDSLKPGERKYYTVELDAASSAYVSAVAAPKPGGTMGVRDGIEVSLQAADGTQCGAGHHRSFLSAGGAYPLADYAERVVKPGAPCRSAGAYRFVVERGDAKGGDDSAVPLELRYVAEPPRKNETEEPAGPGGWSTRAPSGPPPGDGESVAGGTGFNDAAELRPGAWKDELRPGETRFYRVAVEAGEQLFADAEFGAERGGAVPFVVSGVRVGLSNEARGHVLNKTGGYQGRPATVSLATPPAAYGGGAGGGEAARGMRLAGWYYLQVSVNPKVRQTAVPVTLKIATAAARRSEQEPGAGRAAGGVEPVAATSRGTHRQRLRLIGYAGIGTGTALLLGLGVWTLLARRRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEA3</accession>
    <name>A0A2G1XEA3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26395</name>
        <name evidence="3" type="ORF">CYQ11_19245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49558">
        <property type="protein sequence ID" value="PHQ49558"/>
        <property type="gene ID" value="BLA24_26395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14722">
        <property type="protein sequence ID" value="PPT14722"/>
        <property type="gene ID" value="CYQ11_19245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="683" mass="73372" checksum="D5C939FE08C51D6C" modified="2018-01-31" version="1">MPNRLAHETSPYLLQHADNPVDWWPWVPAAFDEARRRGVPVLLSVGYSSCHWCHVMAHESFEDAPTAAYLNEHFVAVKVDREERPDIDAVYMEAVQAATGQGGWPMTVFLTPDAEPFYFGTYFPPEPRHGMPSFRQVLEGVGAAWNDRRDEVGQVARRIVRDLSERTLAVDTTRAPGAEDLHAALLGLTRDFDAVRGGFGGAPKFPPAMTVEFLLRHHVRTGSEAALEMASATCEAMARGGIYDQLGGGFARYSVDASWVVPHFEKMLYDNALLCRAYAHLWRATGSELARRVALETADFMVRELRTAQGGFASALDADSDDGSGRHVEGAHYVWTPAQLREVLGEEDALLAAEYFGVTQEGTFEEGASVLRLPDTDRLWDAAKLASVRARLLAARDRRPRPGRDDKVVAAWNGLAVAALAETGAFFDRPDLVQAATDAADLIVRTHMDWHARLFRTSLDGVAGDHAGVLEDYADVAEGFLALSSVTGEGVWVDFAGLLLDTVLVHFTAPDGALYDTADDAEPLIRRPQDPTDNAAPSGWTAAAGALLAYAARTGSGAHREAAEKALGVVRTLGPKAPRFVSWGLAVAEALLDGPREVAVVGPGDHPATRELHRTALLSTAPGLAVAVGDPGSEEVPLLSGRTLLDGRPAAYVCRHFTCDAPTADPEVLAARLGGSGSGGPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC0</accession>
    <name>A0A2G1XEC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26490</name>
        <name evidence="3" type="ORF">CYQ11_19145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49576">
        <property type="protein sequence ID" value="PHQ49576"/>
        <property type="gene ID" value="BLA24_26490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14705">
        <property type="protein sequence ID" value="PPT14705"/>
        <property type="gene ID" value="CYQ11_19145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="15291" checksum="E61F50FC047AE554" modified="2018-01-31" version="1">MSEPFSVTVTVRGYETDSQGHLNTSVYMQYAEHARWCALEAAGIRQSALLEKGVGPVNLETNLRFHRELRAGDEVGVSCAFAYDGGKTFRIDQRIVKADGTLAAEVTSVGGLLDLRERRLVAEPAGYFRALASDTRVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF68</accession>
    <name>A0A2G1XF68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS lactose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_19700</name>
        <name evidence="12" type="ORF">CYQ11_11095</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49867">
        <property type="protein sequence ID" value="PHQ49867"/>
        <property type="gene ID" value="BLA24_19700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13357">
        <property type="protein sequence ID" value="PPT13357"/>
        <property type="gene ID" value="CYQ11_11095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="437" mass="46419" checksum="9DA34F65C39B3517" modified="2018-01-31" version="1">MSSIAAAAPRRKKRLHGLFQGLQKMGRSLQLPIAVLPAAGILNRLGQPDVFGKDGLGWTDVAKVMAGAGGALLDSSLGLPLLFAVGVAIGMAKKADGSTALAAVAGFLVYYAVLHQFPEPCPPGSTHTALGLLAGVCVTPAGAPAAAAYQNPGVFGGIVMGLLAAWFWQRFHRVKLVDWLGFFNGRRLVPIIMAFVGIVFAALCLWIWPPVGDALTSFSKWLVDLSATGAGIFGVANRALLVVGLHQFLNVFVWFQFGSYTKPDGTVVHGDINRFLAGDPTAGQFTSGFFPIMMFALPAAALAIAHCARPARRKAVGGMMLSVGLTSLVTGITEPIEYSFLFIAPLLYVVHALLTGVSMAVTWGLGVHDGFSFSAGLIDYVINWGLATKPWLIIPIGLCFAVVYYAVFRFAITVFDLPTPGREPEELAEETEKENVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF74</accession>
    <name>A0A2G1XF74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sodium:solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_19800</name>
        <name evidence="9" type="ORF">CYQ11_10990</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49883">
        <property type="protein sequence ID" value="PHQ49883"/>
        <property type="gene ID" value="BLA24_19800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13341">
        <property type="protein sequence ID" value="PPT13341"/>
        <property type="gene ID" value="CYQ11_10990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="507" mass="52697" checksum="B74915F51F4498D7" modified="2018-01-31" version="1">MSADATIATAVFGVFMVLTVALGLLAVRGRGSGGGITEWSVGGRSLGTVFIWVLMAGEGYTSFSYLGAAGWGYNYGAPVLYVIAYMSCGYAIGYVVGPTLWAYARRHGLVTITDMVAHRYGRPWLGTAVAVLATVCLLPYIQLQITGMGVVVSTISYGAISLNWAYFIAFAVTTGFVVVSGLRGSAWVSVLKDVLVIGTLGFLAVYVPLHYFDGYGPFLDRVVAEKPDWLTFSGHGGSGLDGSWFVSTSLLNSLTVVIFPTTVAGYLGARNADALRRNAMLLPLYNVLLFVPMLLGMAAVFVVPGLTGAGSNLALFKLVVDSLPAWAVGLIGVAAALSSIVPMAVFMLVIGTMWGRSALGAVPALARRPDRQKAAAQIVVVASGVLALVMTYTAPNTLVRLSLISYEGMAQLVPMILLGLVWRRLTLWGAVSGLVAGGALVCALVFTEHDPVGGANAGAVALGLNVAVALVVSWLGPKPVDARPDDEVLARDPGRDGSAGAVVGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF90</accession>
    <name>A0A2G1XF90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19930</name>
        <name evidence="4" type="ORF">CYQ11_10860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49904">
        <property type="protein sequence ID" value="PHQ49904"/>
        <property type="gene ID" value="BLA24_19930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13320">
        <property type="protein sequence ID" value="PPT13320"/>
        <property type="gene ID" value="CYQ11_10860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304757" evidence="1">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="20837" checksum="D146AD5453E57F00" modified="2018-01-31" version="1">MRKKISAAVIGLGAACVSVLSTVPASSHGSPDSPTSRQVYCANGTVSDCGEIQWEPQSVEGSKGFPSRGPADGTICSGGNSRFAELDDPRAGGWPATAVTAGQNYSFRWKLTARHATTDFRYYLTNSHYDPTRPLTRADLDPQPFLTVPYGGRIPDATVTHQGRIPSGRSGKQLVLAVWTIADTGNAFYACSDVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFV6</accession>
    <name>A0A2G1XFV6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21290</name>
        <name evidence="2" type="ORF">CYQ11_09495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50122">
        <property type="protein sequence ID" value="PHQ50122"/>
        <property type="gene ID" value="BLA24_21290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13097">
        <property type="protein sequence ID" value="PPT13097"/>
        <property type="gene ID" value="CYQ11_09495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="11606" checksum="F1470BBFB4186B61" modified="2018-01-31" version="1">MTETLDPEDRKLITLARATRARNAVAEGAAVRDETGRTYVAGTVALDSLRLSALRTAVAMAVASGARSLEAAVVVSEAAAASDEDRAAVRDLGGADTPVLLAGPDGTVRTVTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFW9</accession>
    <name>A0A2G1XFW9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">BLA24_21085</name>
        <name evidence="8" type="ORF">CYQ11_09700</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50091">
        <property type="protein sequence ID" value="PHQ50091"/>
        <property type="gene ID" value="BLA24_21085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13129">
        <property type="protein sequence ID" value="PPT13129"/>
        <property type="gene ID" value="CYQ11_09700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="619" mass="67997" checksum="4A93B3DE6C37B404" modified="2018-01-31" version="1">MPATPTNVPEPSRTDPALIRNFCIIAHIDHGKSTLADRMLQLTGVVDQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPTEDPGNTHILNMIDTPGHVDFTYEVSRSLAACEGCILLVDAAQGIEAQTLANLYLAMENDLTIIPVLNKIDLPAAQPEKFAAELANLVGCDPQDVLRVSAKTGVGVDALLDKVVREVPAPVGVKDAPARAMIFDSVYDAYRGVVTYVKVVDGTLSKRERIKMMSTGAAHELLEIGTNSPEMTAADGLSVGEVGYLITGVKDVRQSKVGDTITTLSKGATEALGGYKDPKPMVFSGLYPLDGSDYPELREALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLEVVRERLEREFGLDLIATAPNVVYRVDMEDGTEHTVTNPSEFPTGKIDKVHEPVVRATILAPSEFIGAIMELCQTRRGVLLGMDYLSEDRVEIRYTLPLAEVVFDFFDQLKSKTRGYASLDYEPTGEQTADLVKVDILLHGDKVDAFSAITHKDKAYAYGVRLVAKLRELIPRQNFEVPIQAAIGARVIARETVRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGSVEVPQEAFIAVLSSDEGDKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFX1</accession>
    <name>A0A2G1XFX1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Metal ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21350</name>
        <name evidence="6" type="ORF">CYQ11_09435</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50133">
        <property type="protein sequence ID" value="PHQ50133"/>
        <property type="gene ID" value="BLA24_21350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13086">
        <property type="protein sequence ID" value="PPT13086"/>
        <property type="gene ID" value="CYQ11_09435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="26840" checksum="26E10D1592273B7E" modified="2018-01-31" version="1">MEQPVISVRGATAALGSRPVLRGVDLTVRRGEVVALLGANGSGKSTAVRAIVGQVPLTGGELELFGTPRRRFRDWARVGYVPQRTTAASGVPATVREVVAAGRLARTKLGPTRKADREAVARALELVGMADRIKDSVNALSGGQHQRVLIARALVGEPDLLIMDEPMAGVDLASQEVLASAVREQVSRGTTVLLVLHELGPLEPLIDRAVVLRDGCVVHDGPPPKAVGQHALPGHDHVHPHADPAAEPIRTGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG36</accession>
    <name>A0A2G1XG36_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21730</name>
        <name evidence="4" type="ORF">CYQ11_09055</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50196">
        <property type="protein sequence ID" value="PHQ50196"/>
        <property type="gene ID" value="BLA24_21730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13020">
        <property type="protein sequence ID" value="PPT13020"/>
        <property type="gene ID" value="CYQ11_09055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039480">
        <property type="entry name" value="C-C_Bond_Lyase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15617">
        <property type="entry name" value="C-C_Bond_Lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="389" mass="42522" checksum="30295A74787899A0" modified="2018-01-31" version="1">MRHFGHLAPAVRSGLFHREPGEFDAGSPARTLAVALGATLYSPATRGTLARDVRKQARRGVVSMVLCLEDSISDAEVAGAEENLVRQFAELAAGGTAEGLPLLFVRVREPRQITDLVRRLGPHVRLLSGFVLPKFTEDRGLPFLEALAGAEAGCGRRLFAMPVLESPELLHLETRTETLAGIARAVDKYRDRVLALRLGVTDFCSAYGLRRAPDMTAYDVKLVASVIADVVNVLGRADGSGFTVTGPVWEYFPQPERMFKPQLRRSPFAGPAEALRTALIEHDLDGLLREIQLDRANGLQGKTCIHPSHVAPVHALSVVSHEEFSDAEDILRPERDGGGVLRSAYTNKMNEVKPHRAWAERTMLRAEVFGVAREDVSFVELLAAGLQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG87</accession>
    <name>A0A2G1XG87_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_22045</name>
        <name evidence="7" type="ORF">CYQ11_08740</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50246">
        <property type="protein sequence ID" value="PHQ50246"/>
        <property type="gene ID" value="BLA24_22045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12969">
        <property type="protein sequence ID" value="PPT12969"/>
        <property type="gene ID" value="CYQ11_08740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="170"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="31244" checksum="F14050AA657E5B13" modified="2018-01-31" version="1">MPIDPAKATAAEPRTVPLSWDHKDVLLYHLGIGAGSRQGAPGAATDPRELRYTLESRLHVLPSFATVAGGGMALAGGLTAPGVDVDLAAVLHGGQSVVLHRPIPLRSAAGTRQTSRVEAVFDKGKAALIVLRADVADDDGPLWTCGSEIFVKGEGGFGGERGSTGRLEAPARAADLTAERHVREDQALLYRLSGDWNPLHADPEFAALAGYDKPILHGLCSYGIALKAVVDTVLGGEVARVRSYRTRFAGVVFPGETLRVRMWRDAPRPGSVQLTATAVEREDAPVLTDTVVEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGC2</accession>
    <name>A0A2G1XGC2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional RNase H/acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22080</name>
        <name evidence="4" type="ORF">CYQ11_08705</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50251">
        <property type="protein sequence ID" value="PHQ50251"/>
        <property type="gene ID" value="BLA24_22080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12964">
        <property type="protein sequence ID" value="PPT12964"/>
        <property type="gene ID" value="CYQ11_08705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="395" mass="41175" checksum="231E3EA4C07358C5" modified="2018-01-31" version="1">MANRFVVEADGGSRGNPGPAGYGAVVLDAATGEALAEAAEYIGTATNNVAEYKGLIAGLKAAKALDPDAEIAVRMDSKLVVEQMSGRWKIKHPDMKPLAAEAQRVFPAGRVAYEWIPREKNKHADRLANEAMDAGKAGRQWEPGRSSAGLAAAASAPSGVAAALQVPAAEPLAEPKASPVGWAAPADLGAPTTFVLLRHGETALTPQKRFSGSGGSDPGLSPAGRRQAEAAAAALAARGTIQAVVTSPLLRCRETAGAVAARLGLDVRVEEGLREADFGAWEGLTFAEVRERHPEDLDAWLASSKAAPTGGGESFAAVARRVSLTRDRLLARYASRTVLLVTHVTPVKTLVRLALGAPPESLFRMELSAASLSAVAYYADGNASLRLLNDTSHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGJ5</accession>
    <name>A0A2G1XGJ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_19995</name>
        <name evidence="2" type="ORF">CYQ11_10795</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50368">
        <property type="protein sequence ID" value="PHQ50368"/>
        <property type="gene ID" value="BLA24_19995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16482">
        <property type="protein sequence ID" value="PPT16482"/>
        <property type="gene ID" value="CYQ11_10795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="449" mass="47231" checksum="A618BF257141360B" modified="2018-01-31" version="1">MVRGVAFDPAGAAKAATDAILRDTLHGPHRGVVVDSPPGAGKSTLVVRAARELAAAGRPLMIVAQTNAQVDDLVLRLAEQDPGLPVGRLHSSERRPYDPALDALGSVVTSSRAAELAGLDVVVSTAAKWAHTKVAEPWGHAIVDEAYQMRSDALLAVAGLFERALFVGDPGQLDPFSVVGGDGSAQWAGLSYDPSASAVSTLLAHNPELPQHRLPVSWRLPASAAPLVSDAFYPYTPFRSGTDHGDRHLGFGVPSDGSGPDRVLDEAAASGWGLLELPARHTPRTDPEAVGAVALVVRRLLDRGGAVTSERGPEPVPLTADRVAVGTAHRDQAAAVRAALASLGVAGVTVDTANRLQGREFDVTVVLHPLSGRPDATAFHLETGRLCVLASRHRHACVVVCRAGVDRLLDEHPSTEPVQLGVTVKFPDGWEANHAVLSHLAEHRIAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGN0</accession>
    <name>A0A2G1XGN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20730</name>
        <name evidence="2" type="ORF">CYQ11_10050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50386">
        <property type="protein sequence ID" value="PHQ50386"/>
        <property type="gene ID" value="BLA24_20730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16465">
        <property type="protein sequence ID" value="PPT16465"/>
        <property type="gene ID" value="CYQ11_10050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="136" mass="14759" checksum="CDE314E25972524C" modified="2018-01-31" version="1">MGYDDMSRLNREMTARIEGYHDVVVHGNNKGFFMPGRKNAAGVDFPPGEVSAGHIIEAIRNNPSYNGGPIRLISCHTGVLKEGELGIPAAQAVANELKVPVMAPTDEVGIYPSRGKGQQPEVQNGGYWRTFLPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGR6</accession>
    <name>A0A2G1XGR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_22035</name>
        <name evidence="6" type="ORF">CYQ11_08750</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50422">
        <property type="protein sequence ID" value="PHQ50422"/>
        <property type="gene ID" value="BLA24_22035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16434">
        <property type="protein sequence ID" value="PPT16434"/>
        <property type="gene ID" value="CYQ11_08750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="21348" checksum="8CD294F1411D12F3" modified="2018-01-31" version="1">MIKVLLAEDQGMMRGALALLLGLEDDIEIVAQVGDGDEILPRALELRPDIALLDIELPGRSGLDAAADLRARLPECRVLILTTFGRPGYLRRAMEAGACGFLVKDGPVEELAATIRRVLAGERVIDPALAAAALSAGPNPLTQRERDVLAAAVDGATVADIAAKVHLSPATVRNYLSAAIGKTQTRNRMEAVRAARQNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT1</accession>
    <name>A0A2G1XGT1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folK</name>
        <name evidence="9" type="ORF">BLA24_16545</name>
        <name evidence="10" type="ORF">CYQ11_16740</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50454">
        <property type="protein sequence ID" value="PHQ50454"/>
        <property type="gene ID" value="BLA24_16545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14291">
        <property type="protein sequence ID" value="PPT14291"/>
        <property type="gene ID" value="CYQ11_16740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="21358" checksum="42C16094DBA243D7" modified="2018-01-31" version="1">MSSSDPTVQPVPSSVVERVDAADVTLSNPKRAVISIGSNLGNRLETLQGAVDALEDTPGLRVKAVSPVYETEPWGVESGTQPSYFNAVVLVKTTLPPDSLLERGHAIEEAFERVRDERWGPRTLDVDIVAYQDVVSDDPALTLPHPRAHERAFVLVPWYDVDPEAEVPGHGPVAELLAGLSLESVAPRADLELRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGU8</accession>
    <name>A0A2G1XGU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16635</name>
        <name evidence="3" type="ORF">CYQ11_16650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50468">
        <property type="protein sequence ID" value="PHQ50468"/>
        <property type="gene ID" value="BLA24_16635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14277">
        <property type="protein sequence ID" value="PPT14277"/>
        <property type="gene ID" value="CYQ11_16650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="403" mass="43428" checksum="13DC2813B87193B5" modified="2018-01-31" version="1">MGKKVLISGASVAGPALAYWLGRHGFDVTVVEVAPDLREGGQAVDFRGDTHLTVLERMGVLDDLRRIQTGGTPMVCVDEKGRTRLRLPADFAGGDIEVLRGDLARVLFEHSLPYAEYLFGDSIAGLRQDTGGVHVRFRSGRAGTFDLVVGADGIHSHVRRLAFGPEEEYLSHLGYYAATWSLPNYPGIGFGEGSVGVNVPGRYASVGTDNRDRGTAHAFFLFAAGRLAYDRHDPEQQKALITEAFAGIGWDVPHLLETLKETDELYFDSISRADVPSWSNGRVTLIGDAACGATIGGMGTGTAVVAAYVLAGELAAAGGDHVTAFARYEALLRDYAQGCQRGGDRTGKFLAPGRLGLPVRNWLLRRRRVLDWMLAEGKKATHLELPDYGQRGTVPTGQCARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGU9</accession>
    <name>A0A2G1XGU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16555</name>
        <name evidence="4" type="ORF">CYQ11_16730</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50456">
        <property type="protein sequence ID" value="PHQ50456"/>
        <property type="gene ID" value="BLA24_16555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14289">
        <property type="protein sequence ID" value="PPT14289"/>
        <property type="gene ID" value="CYQ11_16730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="156" mass="16958" checksum="53E3B227D0109B58" modified="2018-01-31" version="1">MSTARTDSERVELANTALYEAMERGDTAAMERLWLKDPGTDVSCVHPGWPVLRGRSEVLRSYALIMASTDYIQFFLTDVEVSVAGDTALVTCTENILSGGPAETEGELGPLVGQLVVATNVFRRSGDEWKVWSHHGSPVLAGREDEEDDDSAEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGW2</accession>
    <name>A0A2G1XGW2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_16740</name>
        <name evidence="5" type="ORF">CYQ11_16545</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50484">
        <property type="protein sequence ID" value="PHQ50484"/>
        <property type="gene ID" value="BLA24_16740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14261">
        <property type="protein sequence ID" value="PPT14261"/>
        <property type="gene ID" value="CYQ11_16545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304854" evidence="2">
        <location>
            <begin position="30"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="127"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="538" mass="56363" checksum="CE9C39FC4F2AF502" modified="2018-01-31" version="1">MDTSRLLRTSGTLVAAAALLISAAVTGSAAPGGTGPDRPRGGLLGPVDDTGGSDAAPPPLAPLPTALPAALRPYYDQKLRWHACSGKRSGFECATMRAPLDYGAPRDGDVKLAVSRKKATGSGKRLGALMVNPGGPGGSAVGFLQQYAASRYPAPVRARYDMVAMDPRGVAASDPVTCLSDQEMDAYARVDQTPDSAAEVRDLVNAYKKFAAGCAARSGKLLRHVSTIEAARDMDIFRAVLGDDKLHYVGASYGTFLGATYAGLYPKRVGKLVLDGALDPSLSAEQINHDQTVGFQTAFASFVEDCAGHENCPLGSSRTDVANSRLKSFFEQLDDRPLPTGTSRELTESLATTGVISAMYDEGSWPVLRKALQNAQSGDGSLLLRLSDAYYERDERGAYTNLMPANSAVNCLDLPTAFHGPAGVYRALPDFEKASPALGTSFAWGALTCAYWPVPATGTPHRIPASGAAPILVVGTTRDPATPYRWAGALASQLSSGRLLTYDGDGHTAYTRGSSCVDGAVNTYLLTSASPPASQKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGZ3</accession>
    <name>A0A2G1XGZ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16940</name>
        <name evidence="3" type="ORF">CYQ11_16340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50514">
        <property type="protein sequence ID" value="PHQ50514"/>
        <property type="gene ID" value="BLA24_16940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14230">
        <property type="protein sequence ID" value="PPT14230"/>
        <property type="gene ID" value="CYQ11_16340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="73" mass="7602" checksum="A40DE136DD1E7131" modified="2018-01-31" version="1">MGDLPRTHSPFGPFKIGPEGGVAPCPPSVTSSTGNGEYAAAAVGEPRFGRGRRQHGLGNRLECAGRLPHYRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH01</accession>
    <name>A0A2G1XH01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16970</name>
        <name evidence="2" type="ORF">CYQ11_16310</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50518">
        <property type="protein sequence ID" value="PHQ50518"/>
        <property type="gene ID" value="BLA24_16970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14227">
        <property type="protein sequence ID" value="PPT14227"/>
        <property type="gene ID" value="CYQ11_16310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="14248" checksum="AE120DD21A3181DE" modified="2018-01-31" version="1">MTTALQPPPPSRPLLRLRLAPHAGMPRPIDGAWWPRSHDLLAELPWLLAGLPRAWGHITSVTVNGTTWSAVPGRTLVFNQVVRLRRTVAASAPHTIILLAPGRGRWDLLVVPPDTTEEAAEPLMAAAASGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH27</accession>
    <name>A0A2G1XH27_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_17105</name>
        <name evidence="13" type="ORF">CYQ11_16170</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50536">
        <property type="protein sequence ID" value="PHQ50536"/>
        <property type="gene ID" value="BLA24_17105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14210">
        <property type="protein sequence ID" value="PPT14210"/>
        <property type="gene ID" value="CYQ11_16170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="274"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113026" checksum="97FE5B37344383AF" modified="2018-01-31" version="1">MAKGIREREFQNLMIQWSLPMGWGFTAGRSLQRETTQTVIAGQLRDAIVRLNPGVIDGFDVDAVVEEIVTTVNAVEGGLVRANEQVLRLLRGYKEFRDTDGVWHALKVIDFARPTANTLVVSDEVTITVPGKTSRRFDLVYWVNGLPLVVVEVKSPTAKSAWADAAREINNVYATEYPWFFTPNVFAVASDGLKLRFGAVGSPTNLWQPFRSTADDENLSGQADVQRSAQLLLNPSTVLDMLANFTLFDTAGGGADKKYLPRYPQMEAAHLIHERVLEGGSKGLVWHHQGSGKTLLMVFAASLLLADTRTESPTIILLSDRTHLVRQTSGVFTSAMGDAYFHQPATSKELRSLLADDVRGVISTTVHKFADAGKHLSTRNNIIVLVDEAHRTQSAKSKSLAGQMRAALPHAKFFGMTGTPIRNLATDTFALFGEEADPGRVMHRYSVSRSLLDEATVPVMLAPRPVSFEIDDQALQAEFDQFADDFDLDDPDRETLSRKFGRLTSVFANPERIHAVCQDIVDHYLAGAYRNGLKAQVVAFNRELAVAYTDKINELLAGFEASQVLAEVGKHGRITAEVNISVSDSKDEDPAMRPYQLSETEEEEQKRRFLAADDPLCFLVVTAKLMTGFDAPNEGVLYLDKPLKAHTLFQTITRPNRTWVSPTGFVKTSGVVVDYIGLAEEVQRAVVDPTTRGTGKGGGFVTDLSELVAEFRTIFARIEDLFADVDDLDLTVHGYESVRAINVFLDSNPGAAEVFSRDYRLLARLYPLINTDKRVAKYRDGFALFGSAYTTLFKKSSDEERKERLAELGPMVLDIINAHVHSFSVVASQEEALVLDAQGIAILKELLALVRPKSDKGGGEDKRPPSAAEILAHIKAALDKGVEPGSAKYTALAERIKQLRDRIIQNAQDALEFLSEALRIARAIVNAEKHPDEAVVLDDDHVGVLSRIIHDHAPSGLTVTERNLAEEIDQVVTRTLAQAWDNADARNRGARRATAAVFRRYMLKPVGEPYDSTVAYIEAHYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH44</accession>
    <name>A0A2G1XH44_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17265</name>
        <name evidence="3" type="ORF">CYQ11_16010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50564">
        <property type="protein sequence ID" value="PHQ50564"/>
        <property type="gene ID" value="BLA24_17265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14182">
        <property type="protein sequence ID" value="PPT14182"/>
        <property type="gene ID" value="CYQ11_16010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="172" mass="18397" checksum="223C51BEA649F14F" modified="2018-01-31" version="1">MYFAALLARTDDGWEASDTELDNVETLADLVDLARENSVDDDTVLALIEQEDSWFAIVRVDGEDDPRVYVSDAVAANRSSYGAMLVDELIGREEDADDELDSLDLDGTEDGEPEEDEGDGDAAERAPSGPLGDGELLSDLGVSGKELRALDGDALGTITDALGCREVLEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHC3</accession>
    <name>A0A2G1XHC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YibE/F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17705</name>
        <name evidence="4" type="ORF">CYQ11_15570</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50632">
        <property type="protein sequence ID" value="PHQ50632"/>
        <property type="gene ID" value="BLA24_17705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14113">
        <property type="protein sequence ID" value="PPT14113"/>
        <property type="gene ID" value="CYQ11_15570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="467" mass="48462" checksum="7F65DD6A653DE95C" modified="2018-01-31" version="1">MNRSDPPPPSAAPRPPSQSPSPDGPSPTPPSHGRSHGHGHGHSHGHSHAHGHGPAAPVSSHLRKVIAAVLIPFAAAVLAGLFVLWPGGAPPHRHSGLGLDQQTESGRVVKIEETDCSQGGAQPPQQQPPGGGPPAKQGPCQNATVEVTSGPDKGRTFPEIVRPDASRRYDVGEKVVLAYAPKAPENLRYSVMDVDRTMPMALLAGLFALAVVVVGRLRGVFALVALAISFGVLTLFILPAILQGSDPLLVAVIGGSAIMLIALYMCHGLNARTSVAVLGTLTSLLVIGLLGTVFTEWARLTGNTDDQTGLVHGLYPEIEIRGLLLAGIIIGSLGVLDDVTVTQTSAVWELKEADPSAGWRKLYGAAMRIGRDHIASVVNTLVLAYAGASLPLLLLFTIADSGVGTVATSEIVAEEIVRTLVGSIGLVASVPVTTVLAALVVSADRHNAVARSGGRSRARGGRRRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHJ8</accession>
    <name>A0A2G1XHJ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF2662 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phosphopeptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18115</name>
        <name evidence="5" type="ORF">CYQ11_15160</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50703">
        <property type="protein sequence ID" value="PHQ50703"/>
        <property type="gene ID" value="BLA24_18115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14043">
        <property type="protein sequence ID" value="PPT14043"/>
        <property type="gene ID" value="CYQ11_15160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="30273" checksum="FDE10C1351566E3E" modified="2018-01-31" version="1">MGVLKRFEQRLEGLVNGTFAKVFKSEVQPVEIAGALQRECDNNATIWNRDRTVVPNDFIVELSAPDFERLSPYSGQLGDELSGMVRDYAKQQRYTFMGTIKVHLEKADDLDTGLYRVRSRTLASSESQDPHASRQQTGAPRAGGGPTQGAGYPAQPAGAPPMPTSPPPGVRPLPRTGGPGPGTVPGAQTRRWIEINGTRHQISRPTLVLGRSTEADVRIDDPGVSRRHCEIRVGTPATIQDLGSTNGIVVDGQHTTRATLRDGSRIVVGSTTIVYRQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK6</accession>
    <name>A0A2G1XHK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18160</name>
        <name evidence="3" type="ORF">CYQ11_15115</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50710">
        <property type="protein sequence ID" value="PHQ50710"/>
        <property type="gene ID" value="BLA24_18160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14037">
        <property type="protein sequence ID" value="PPT14037"/>
        <property type="gene ID" value="CYQ11_15115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="12042" checksum="D63A07D0BD563223" modified="2018-01-31" version="1">MHFGSGIPTVGVDALSSDDFLLDVRELDEWQAGHAEGALHVPMSEFVARFGEVTEKASEGGRINVICRSGGRSAQVTAYLVQQGMDAVNVEGGMQVWEASGRPVVAGDGVPGTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI55</accession>
    <name>A0A2G1XI55_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17050</name>
        <name evidence="8" type="ORF">CYQ11_16230</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50871">
        <property type="protein sequence ID" value="PHQ50871"/>
        <property type="gene ID" value="BLA24_17050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16601">
        <property type="protein sequence ID" value="PPT16601"/>
        <property type="gene ID" value="CYQ11_16230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="20430" checksum="0CF71084785951AB" modified="2018-01-31" version="1">MPSVSAVSSMTTVPADADEARAAGTTVDHLTETYRAHYRSLLGLAALLLDDTASCEDVVQEAFIRVHSARGRVRDPEKTLAYLRQTVVNLSRSALRRRILGLKLLSKPMPDMASAEEGAYEQLERDQLIKAMRGLQRRQREVLVLRYFADMTEAQVAETLGLSLGSVKAYGSRGIAALRIAMEAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI59</accession>
    <name>A0A2G1XI59_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_18310</name>
        <name evidence="9" type="ORF">CYQ11_14965</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50900">
        <property type="protein sequence ID" value="PHQ50900"/>
        <property type="gene ID" value="BLA24_18310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14007">
        <property type="protein sequence ID" value="PPT14007"/>
        <property type="gene ID" value="CYQ11_14965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="484" mass="50392" checksum="B8149249172ACCCA" modified="2018-01-31" version="1">MTSTANPGQRFREFKMPDVGEGLTEAEILKWYVNVGDTVSDGQVVCEVETAKAAVELPIPFDGVVHELRFPEGTTVDVGQVIISVDTQPGAGPAEEAPASTAAHAEKSAASALAAEAEPEQQGRQAVLVGYGAAPSSTKRRPRKARPDADRSSVAAAVQAELNGHVAQVPAPAAPAVPPPAAAPAGAARPLAKPPVRKLARDLGVDLAVITPTGDGGVITREDVHAAAAPAPVAQPAPQEQPVAVPAAPAAARETRIPIKGVRKATAQAMVASAFTAPHVTEFVTVDVTRTMKLVQKLKDDPDMAGLRVNPLLLVAKALLVAIRRNPDVNASWDEENQEIVRKDYVNLGIAAATPRGLIVPNIKEAQAKTLPELSRALGDLVATAREGKTSPADMSGGTVTITNVGVFGVDTGTPILNPGESAILAFGAVKLQPWVHKGKVKPRHVTTLALSFDHRLVDGELGSRVLADIAAVLENPQRLITWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIE4</accession>
    <name>A0A2G1XIE4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_18295</name>
        <name evidence="6" type="ORF">CYQ11_14980</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50899">
        <property type="protein sequence ID" value="PHQ50899"/>
        <property type="gene ID" value="BLA24_18295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14010">
        <property type="protein sequence ID" value="PPT14010"/>
        <property type="gene ID" value="CYQ11_14980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="226" mass="24700" checksum="E57A02F86CDFC293" modified="2018-01-31" version="1">MRVQGKITVFLLDDHEVVRRGVHELLSGEEDIEVVGEAGTTADALVRIPATRPDVAVLDVRLPDGSGVEVCREIRSQDENIKCLMLTSYADDEALFDAIMAGASGYVLKAIRGNELLSAVRDVAAGKSLLDPVATARVLERLRDGKGARGDDRMASLTEQERRILDLIGEGLTNRAIGERLHLAEKTIKNYVSSLLSKLGMERRSQAAAYVARRQAEKRQGAGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XII4</accession>
    <name>A0A2G1XII4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="7" type="ORF">BLA24_14730</name>
        <name evidence="8" type="ORF">CYQ11_13340</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51033">
        <property type="protein sequence ID" value="PHQ51033"/>
        <property type="gene ID" value="BLA24_14730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13744">
        <property type="protein sequence ID" value="PPT13744"/>
        <property type="gene ID" value="CYQ11_13340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="30522" checksum="2DC08C03D1B1F06A" modified="2018-01-31" version="1">MGIRKYKPTTPGRRGSSVADFVEITRSTPEKSLVRPLHSKGGRNNAGRVTVRHQGGGHKRAYRLIDFRRHDKDGVPAKVAHIEYDPNRTARIALLHYLDGEKRYIIAPRGLSQGDRIENGPTADIKPGNNLPLRNIPVGTTIHAIELRPGGGAKIARSAGSSVQLLAKEGTMAHLRMPSGEIRLVDVRCRATVGEVGNAEQSNINWGKAGRMRWKGVRPTVRGVAMNPVDHPHGGGEGKTSGGRHPVSPWGQKEGRTRSPKKASNKYIVRRRKTNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIK8</accession>
    <name>A0A2G1XIK8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">BLA24_14770</name>
        <name evidence="7" type="ORF">CYQ11_13300</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51040">
        <property type="protein sequence ID" value="PHQ51040"/>
        <property type="gene ID" value="BLA24_14770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13737">
        <property type="protein sequence ID" value="PPT13737"/>
        <property type="gene ID" value="CYQ11_13300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="107" mass="11619" checksum="9D765BA6259B7BC2" modified="2018-01-31" version="1">MKIKKGDLVQVITGKDKGKQGKVVQAMPAENRVLVEGVNRVKKHTKAGQTARGSQTGGIVTTEAPIHVSNVQLVVEKDGKKVVTRVGYRFDENGNKIRVAKRTGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ58</accession>
    <name>A0A2G1XJ58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15820</name>
        <name evidence="4" type="ORF">CYQ11_12255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51221">
        <property type="protein sequence ID" value="PHQ51221"/>
        <property type="gene ID" value="BLA24_15820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13555">
        <property type="protein sequence ID" value="PPT13555"/>
        <property type="gene ID" value="CYQ11_12255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="447" mass="46653" checksum="914356742DD4B79E" modified="2018-01-31" version="1">MPSKTRAHDLAAATPSTRDRYVDLLRVASLATVVLGHWLMSAVTTDAHGRTKVGNLLAVEPSLQAVTWVLQVMPVFFFVGGFSHALSYRSLTRRSQGPAYAAFLRARLQRLLRPTMVFIAVWGTGALAAQLLGGGGALADTAARLVAQPLWFIGIYLAMVAFTPPLLRLHERYGWGAFAALVAAAVAVDVLRFAADVPFVAFLNFAFVWLAVHQLGFLRADGRLRLPALLALGGLAAAVALVALGPYPLSMVGMPGEKISNMSPPTAALLCHGMWLVGAVETLRGPGARLVARQRVWRAVIVANGVAMTAFLWHLTAMLGVYGVLLALDVPPPAPAGAAWWAQAPLRIAAAAAVTAVLVAVFRRVERPSAAVAAATARRASGPLAALGVTLALFGVLGLSTVGFGGLLQGHTAVLVAVRVTAPAAVLTAAAGWLLVEAAAPRRGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJJ1</accession>
    <name>A0A2G1XJJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13720</name>
        <name evidence="4" type="ORF">CYQ11_01415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51393">
        <property type="protein sequence ID" value="PHQ51393"/>
        <property type="gene ID" value="BLA24_13720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11733">
        <property type="protein sequence ID" value="PPT11733"/>
        <property type="gene ID" value="CYQ11_01415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="2">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="167"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="539" mass="59507" checksum="88CB3E32CCED36B3" modified="2018-01-31" version="1">MAEGPGSCWFLPEAVYLRRRFLTLTAAATALAFTAGSPRVRAGELRGRELAENPFTLGVASGDPLPDSVVLWTRLAPRPLEPDSGLPPAGTVPVTWEIAEDEAFSRVTRRGTANAEAADGYSVHVDATGLEPARTYWYRFRAGSWLSPAGRTRTAPAADATPSRLRLGVASCQQYDDGYYTALAHLAREDLDVVFFLGDYIYENAIDSRGGSRQLPEGRRLPDVFHHETVTLADYRLRYALEKTDPDLQAAHAAHPWCVTWDDHEVANNYAGGVSQHNDPVDQFLLRRAAAYRAYWENMPLRPAQRPTGPGMRLHRRFQHGRLAQFDVLDTRQYRSDQAYGDGWKQPGPESEDPARTLLGPEQEAWLASGFRASTATWNVVPQQVAFCRRRLTPERSPLSMDAWDGYPAARRRLLDAARTAGVTNLMVLSGDSHIHLAMDIKDDFDNPSSATRGVEVLGTSVSSGADGMEKPEDWESLLRANPHMAYYAKRRGYVVVTLTPSQAQADYRILPYVTRPGAPASTAVSLVCPAGRPGFVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJR2</accession>
    <name>A0A2G1XJR2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13235</name>
        <name evidence="3" type="ORF">CYQ11_00955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51473">
        <property type="protein sequence ID" value="PHQ51473"/>
        <property type="gene ID" value="BLA24_13235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11655">
        <property type="protein sequence ID" value="PPT11655"/>
        <property type="gene ID" value="CYQ11_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="142" mass="15898" checksum="26CE7F91FFDE8EF2" modified="2018-01-31" version="1">MMSIKKFQVTFDCAEPERLARFWCEVLGYVVPPPPEGFATWDDFKRSQPPEQQDAWFACVDPSGVGPRLYFQRVPEGKAAKNRLHLDVRVGTGLVGEERLAALEAECARLVPLGAVHVRTLYDGNDACIPMLDIEGNEFCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK41</accession>
    <name>A0A2G1XK41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12960</name>
        <name evidence="4" type="ORF">CYQ11_17320</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51602">
        <property type="protein sequence ID" value="PHQ51602"/>
        <property type="gene ID" value="BLA24_12960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14395">
        <property type="protein sequence ID" value="PPT14395"/>
        <property type="gene ID" value="CYQ11_17320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="24212" checksum="DE6C97A812B07A8E" modified="2018-01-31" version="1">MPRDTLTVDQIVRAAIELLDEEGLDGLNMRSLGKRLGAAATAIYWHIKTKDDLVRLAGDAIWDEVELPDPDAADWRQAATALATGMHAMLGRHPWFVQACGSHLLYGAGKSRYDDRCLAVYENAGFGAADADRAAATVFIFVLGNALGPAVEVSLARRLSKNGKDAGQHMADAVARAGEIAMRFPRLRERLGTTAAADYAAAPDSSFEFGLAAILDGFEVRLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK70</accession>
    <name>A0A2G1XK70_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2267 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13180</name>
        <name evidence="2" type="ORF">CYQ11_00900</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51539">
        <property type="protein sequence ID" value="PHQ51539"/>
        <property type="gene ID" value="BLA24_13180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16269">
        <property type="protein sequence ID" value="PPT16269"/>
        <property type="gene ID" value="CYQ11_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13578" checksum="57D530F0E075BB18" modified="2018-01-31" version="1">MLEKVRYEGAYPTRERAEEAVRLVVSGLGRQLTGDERVELAARLPFEAARILTAQIPDTQPLTGWAFVKDLAARTGATLGTTRWDTGSVLAAVAALAGPDLLTRILRQLPSGYALLFGRAELTQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK72</accession>
    <name>A0A2G1XK72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12635</name>
        <name evidence="6" type="ORF">CYQ11_17010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000142">
        <property type="protein sequence ID" value="PHQ51635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51635">
        <property type="protein sequence ID" value="PHQ51635"/>
        <property type="gene ID" value="BLA24_12635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14339">
        <property type="protein sequence ID" value="PPT14339"/>
        <property type="gene ID" value="CYQ11_17010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="45"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="134"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="329" mass="34183" checksum="42C2CA73DB752C48" modified="2018-01-31" version="1">MSDWPHILIGTSTDMTAALFPPDLRARLAACGTVTTGRAAADAAADVLITGWGSPPLTADVLGGTPRLRLVVHAAGSVKGLVTPTVWERGIAVSSAADANAGPVAEYAYALVVLAAKQALTSAASYAARGGRAGWPVFQDRRGADGLTVGVVGASRIGRRVVARLRSASAGYRVLLHDPCVPPDEAKRLGAELVDDVDALCGASRVVTLHAPELPETRGLLNAERLALIPDGGTVVNTARGSLVDTESLVRECASGRLNAFLDVTDPEPLPHGHQLLALPNVLVTPHIAGAQGSEVRRLGAYAVEEVERWVLGLPLRGAVRRADLDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKD9</accession>
    <name>A0A2G1XKD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_11475</name>
        <name evidence="6" type="ORF">CYQ11_02710</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51705">
        <property type="protein sequence ID" value="PHQ51705"/>
        <property type="gene ID" value="BLA24_11475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11954">
        <property type="protein sequence ID" value="PPT11954"/>
        <property type="gene ID" value="CYQ11_02710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="114" mass="11979" checksum="34225F7C653CD05B" modified="2018-01-31" version="1">MNVLPYLTAAWVFLVGVYGMATSRNLVHAVGCLSVTQSATYVLLLAVGYRRGGTAPVFSDIPVGTRVVDPVVQALALTDVVVGATVTALLLSLVVQVEKRHGTVDPDELSELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKH4</accession>
    <name>A0A2G1XKH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11655</name>
        <name evidence="4" type="ORF">CYQ11_02895</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51738">
        <property type="protein sequence ID" value="PHQ51738"/>
        <property type="gene ID" value="BLA24_11655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11986">
        <property type="protein sequence ID" value="PPT11986"/>
        <property type="gene ID" value="CYQ11_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="147"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="363" mass="38177" checksum="4CEC6BFD90B86D7F" modified="2018-01-31" version="1">MKRDPGPGAPPGTPPLPRAARSLVVAAYALLGVAVVTDLATNPTLTFSPVLATTPVLASIGTRRARVPLLAGLLALAIVAPLALADPDVALPVHLTAGATVLAITCVSTANVILVATRERELLQSRSVAEAAQRTLLRPLSERINGFRVAVRYQAAAAEARVGGDLYEVLATPFGVRLLMGDVRGKGLSAIETASDVLGTFREAAQVESDLTAVARRLDATVARRRVREEFVTAVVVAMPGAGDAGELVNCGHLPPLLRRRGEVTELESPVPDPPLALRCLVGGPYHRRRFSFAPGDQLVLYTDGVTEARDASGRFYPLAERLAGMPDLAPDPLAARIVADLRAYTGGGLADDAALLVVRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKM3</accession>
    <name>A0A2G1XKM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GMC family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_11950</name>
        <name evidence="6" type="ORF">CYQ11_03190</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51788">
        <property type="protein sequence ID" value="PHQ51788"/>
        <property type="gene ID" value="BLA24_11950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12034">
        <property type="protein sequence ID" value="PPT12034"/>
        <property type="gene ID" value="CYQ11_03190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="3">
        <location>
            <begin position="434"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="4">
        <location>
            <begin position="622"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="781" mass="84875" checksum="C78A90A2B642A7A8" modified="2018-01-31" version="1">MPGLRRRERPPHRLRRVHTAGHRPGPPLPRHHRRTGGPGGGGPLPRRPGRRRGRPRRPHRRGVPRHRPRHHPPVVPGRLAPALPLRARGPGPREAQHRLHRLTRGVHRGTGLADLPRPPARRQGPGLRHLGGPAARRPRPSPAHGGGRPVTAGPARPATPRYDVVVVGAGLAGSLVAKRLGDRGWRVLVLEAGTRTLDSWPGHLDALDTAHAALAKVPNAPYRRNPAAPFPDVLDLTGLPDGGYRADGYFLQNGPLPYGSDHLRATGGTALHWMGLAPRMHPDDFHVRRAYGYGRDWPLAYDDLEPHYRAAERELGVAGDADEQRDAIGLPFPPGYGYPMHKIPRSYLDSVIAARLDGVRLREAPDAPETTLRVVTTPHARNSTPNPGYDSGRGHRPRGAVGTPNYGERCVGHAFCVPICPVQAKYTPLKTQATWSDDVTLVAHAVVSRVLTAGNGRVLGVEYQRYDDPASPAHTTRTAEADLVVLAAHAVENAKLLLLSGLADASGQVGRNLMDHPVLLTWGLLDHPAGPFRGPGSTSGLECFRTGPARRDRAPFRVEIGNWGWSWPAGSPSGDVSRLLGITGDPSQPRGKGLFGARLRRELGHFVGRQFSFQFAFEQDAESRNRVTVDPRHRDRLGIPRPVLTYDLSDHVKRGIASAKAVSDQLFRLLGAEDHTAYAPGTSAPGWFRHGDGAFEFKGAGHAAGTHVMGASRADSVVDPWQRCWDHPNLYAVGCGSMPSVGTSNPSLTMAALTLRSCERMHRDLTELHRPAALRLPEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL22</accession>
    <name>A0A2G1XL22_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_12235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51839">
        <property type="protein sequence ID" value="PHQ51839"/>
        <property type="gene ID" value="BLA24_12235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1998"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="3219" mass="335313" checksum="ACB70B0622775D76" modified="2018-01-31" version="1">MADNADNDKLFDYLKRVTADLQKTRQRLAEVQDAEQEPIAIVGMSCRFPGGIESPEQLWQLVAEGGDAMTPFPADRGWGIASGGDEDASPVGGFVHDATTFDAGFFEISPREALAMDPQQRMLLEAAWEGLERAGIDPASMRGSRTGVFAGASSSAYGLGLSELPEGVEGYLMTGSSTSVVSGRVSYALGLEGPAVTVDTACSSSLVALHLAVQALRRDECSMALAAGVTVMVLPGVFAEFSRQGGLAGNGRCKAFADSADGTGWSEGVGLLVLEKLSDARRNGHKVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRDALTSARLSPADVDAVEAHGTGTKLGDPIEAQALIATYGQDRPEGRPLWLGSVKSNIGHSQQAAGVSGLIKMVMAMQHGVLPQTLHIDRPTSQVDWSAGEVELLTEARPWPESGRPRRAGVSSFGVSGTNAHVIIEQAPEAEEPAPATAAPARPAGVVPWLLSAKSAAALKAQAQRLLDALAADSSPLDVAFSLATTRTALEHRAVVVGDDRDALLRGLAAVAEGTPASGVVSGLARDTGQLAVLFSGQGSQRAGMGRELYETFPVFAEALDAVCAEFDRVLDRPLREVMFEAGEELDQTGYTQPGLFALEVALYRLVESWGVRPDYVTGHSIGELAAAHVAGVLSLADAATLVAARGRLMQALPTGGAMLAVGADEATVAAHLEGREAQVSIAAVNGPSSVVIAGDEDVVVELGETFAQAGHKTRRLRVSHAFHSPHMDAMLDDFRRVAEGLAYEQPRIPVVSNLTGQTEDVASADYWVRHVRGAVRFSEGVRWLEGQGVSAFLELGPDGVLSGMAQESLSDEPALIAALRKDRPEPEALVTALGRLHTTGSRVDWAAFFTGHDAQPVDLPTYAFQRERYWLDHGRHHVGDVASIGQGTTDHPLLGAAVTLADGDGVLMTGRLSLQSHPWLADHRISGAVLVPGTAFVELAVRAGDEVGCDRVEDLTIEAPLVLSETGGVHIQLTVGAADASGRRTLSVHSRAEDAPADQPWTRNAGGLLAADGRRPAFDLAQWPPADAEPLDADGLYERLTDLGYGYGPVFQGLRAAWRRGEEIFAEVAVPEDQHREAGRFALHPALLDSALHAVGLAELDRGGLPFAWSGVSLYATGASALRVRLAAAGSDGVELSVADASGAPVASIDSLVFRRVTADRLTPVAGSRTDSLYRIDWTALPAADAAGVTERPWALAGTDALAVRGGLAAAGVDVSVHADLAGLADDTEVVLLPVAAPEAGVPAAEAARAATHGVLAFLRDWLADERLADSHLVVLTRGAVTTDAAADADVTDLAGAAVWGLVRSAQSENPGRIVLADLDAEAASAEALPAALATGEPQLALRDGKAYAPRLARTATGSGLVPPAGPWVLDTLGGGTLEGLVLSEAAERAPLAPEEVRVAVRAAGVNFRDVLIALGMYPGATVMGAEAAGVVVETGTEVTGLAVGDRVMGMAGKTFATETVTDHRHLIRMPEGWSFERAASTPIVFLTALFGLRDLAGLGAGQRVLVHAGAGGVGMAAVQLARHLGAEVFATASEGKWDVLRSLGLDDDHIASSRDLEFEEKFLAVTGGEGVDVVLNSLAGEFVDASLRLLPRGGWFLEMGKTDIRDAEAVAAAVPGLRYRAFDLYEAGPEHTQTLLVDLLGLFEQGALTALPLKTWDVRRAREAFRFISQAKHVGKVALTMPRELDPEGTVLLTGATGTLGGVMARHLVAERGVRHLVLLSRRGADAEGAAELEAELTELGAEVRFAACDVADREALAGVLGSLERPLTGVVHTAGVLDDGVISSLTPERIDGVFRPKVDAALNLHELTRDLDLAMFVLFSSAAATVGSAGQGNYAAANAFLDALAQHRRALGLPGQALAWGMWAQRSAMTGDLGEADLARMNRGGFGAHTSAEGAALFDTATTVDAAVLVPMKIDTAALPAEGLPALLRGLVRTPARRTASNAAAGDGASELTRKLAGLSEDDQLEVLVGLVRGHVATVLGYPSSDDVAPERTFQELGFDSLTSVELRNQLNAVTGLRLPATLVFDHPTPNVLARFLRDEALGVVAAEPSAAHPVTGHGTSAADDPIVIVGMSCRYPGGVESPDDLWRLVAAGGDAVSDSPDDRGWPAADDVAGGRGGYVRDVSHFDAGFFGISPREALAMDPQQRLLLEAAWEVFERAGIDPAAMRGTLTGVFAGASSSGYGTGHQQLPEGVEGYVMTGTTTSVVSGRIAYTFGLEGPAVTVDTACSSSLVALHLAAQAIRNGECTMALAGGVTVMSSPGIFTEFDRQGGLSRDGRCKAFGAGADGTGWAEGVGLVLVERLSDARRNGHQVLAVFRGSAVNQDGASNGLTAPNGPSQQRVIRQALANARLVPGDVDVVEAHGTGTTLGDPIEAQALLATYGQDRPEDRPLWLGSVKSNIGHAQAAAGIAGVIKMVMAMRHGVLPRTLHADEPTPEVDWSSGAVSLLTAPTAWPQSGRPYRAAVSAFGVSGTNAHAILEAAPAAEEPEGPAESGPALAPVPWVLSARTPQALAAQAERLHRHLAALPGADAAGIGHALATTRSVLEHRAAVVGHDTEELLSGLAALAEGTQAPHAVTAEPRTAGKLAVLFTGQGSQRAAMGRELHAAFPVFADALDAACAELDQHLERPLKEVLFAADGTAEAELLHRTDFTQAALFAVEVALFRLVEAHGVKPHYLMGHSIGELSAAHVAGVLSLADAAALVAARGRLMQALPTGGVMIALQASEDEVLPTLFGREHQLSVAAVNGPTSTVIAGDEAAAEEVADHWRAQGRKVKRLRVSHAFHSPRMEPMLADFARVAEGLTFNAPQIPVVSNVTGRVEDVASADYWVRHVRQAVRFLDGMHRLAEQGVTTYLELGPDGVLTGLGQDCLPDAADALFVPALRAGRAEPLSLATAVARLHVHGVPVDLTAAFAGRRHRRVELPTYAFQRRSFWLAPAGQGAGDVSSAGLDAAHHPLLAAATELPDGGGVLFTGLLSRRTHPWLADHVVSGLALVPGTAFVELAVLAGDRVGCDRIDELMLEAPLVLPEKGGVRLRVVVAEADDSGRRALSVHSRPEDAAGDEPWLRNASGLLAPGSAEPAFAFEAWPPADATAVDTTGLYTGLAEAGLAYGPAFQGLRAAWRRGDEVFAEVALPEAQRESAGTFGLHPALLDAALHAAGLTGGEDDGQAGLPFAWSGCPCTPPAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLB2</accession>
    <name>A0A2G1XLB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000108">
        <property type="protein sequence ID" value="PHQ52006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52006">
        <property type="protein sequence ID" value="PHQ52006"/>
        <property type="gene ID" value="BLA24_10155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="411" mass="43504" checksum="9D66BD25EF8631DC" modified="2018-01-31" version="1">MRSPKLAALELRRFGRGRLPRAALVALLLLPLLYGALYLWSFWDPYGRLDKVPVALVNADRGTEVDGQRLDAGASIAEGLRGSKSFAWHETSADDAREGVEKGKYYLSLTIPPDFSDKVASSSGASPVAGALQVRTNDANNYIVGQISRTVFSEIRATASRKASRSFYDRIFVSFSGLHDKTQKAAEGADRLGEGIGEARKGAGDLKDGLARAERGSGDLESGVAQLHTGAGTLDSASGELASGAQKVASGTQRLADKVNGVAGKEGAFVKEHAREIGATARDVAKEAQTVREHLDDLPSPATTALLASGSRRGAEDLAAAYAKACPPAGAPGFCPTLKKAVFAAQQSAAGAEKLNTLMQNKNGELDRLPGRLDTLRGYALRLAAEAPHLGRRRRRRRPSATCNALSRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLD8</accession>
    <name>A0A2G1XLD8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannose-1-phosphate guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_09820</name>
        <name evidence="7" type="ORF">CYQ11_04270</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52040">
        <property type="protein sequence ID" value="PHQ52040"/>
        <property type="gene ID" value="BLA24_09820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12219">
        <property type="protein sequence ID" value="PPT12219"/>
        <property type="gene ID" value="CYQ11_04270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="384"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="532"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="640"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="831" mass="89462" checksum="0F869EB252030010" modified="2018-01-31" version="1">MKAVVMAGGEGTRLRPMTSSMPKPLLPVANRPIMEHVLRLLKRHGLTETVVTVQFLASLVKNYFGDGEELGMELTYANEEKPLGTAGSVKNAEEALKDDAFLVISGDALTDFDLTDLIRFHKEKGALVTVCLTRVPNPLEFGITIVDEGGKVERFLEKPTWGQVFSDTVNTGIYVMEPEVFDYVQPDVPVDWSGDVFPQLMKEGKPIFGYVAEGYWEDVGTHESYVKAQADVLEGKVDVDLDGFEISPGVWVAEGAEVHPDAVLRGPLYIGDYAKVEAGAEIREHTVVGSNVVVKTGAFLHKAVVHDNVYVGQQSNLRGCVVGKNTDIMRAARIEDGAVIGDECLVGEESIIQGNVRVYPFKTIEAGAFVNTSVIWESRSQAHLFGARGVSGILNVEITPELAVRLAGAYATTLKKGATVTTARDHSRGARALKRAVISALQASAIDVRDLENVPLPVARQQTARGSAGGIMIRTTPGVPDSVDIMFLDERGADLSQAGQRKLDRVYARQEYRRAFPGEIGDLSFPSSVYDSYTGSLLRSVDTAGVAEAGLKVVVDASNGSAGLVLPSLLGRLGVDALTINPGLDEARPTETADARRSGLVRLGEIVSSARAAFGVRFDPVGERISLVDERGRIVEDDRALLVLLDLVAAERRSGRVALPVTTTRIAEQVAAYHGTQVKWTTTSPDDLTRVCRQESTIFGGDGRGGFIVPESSSVFDGTAAFVRLIGLVARTQLTLSQIDARIPRAHVLRRDLATPWAVKGLVMRHVVEAAGDRSVDTTDGVRVVEADGRWVMVLPDPAEAVTHLWAEGPDDASAQALLDEWSAVVDGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLI6</accession>
    <name>A0A2G1XLI6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09265</name>
        <name evidence="3" type="ORF">CYQ11_27875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52103">
        <property type="protein sequence ID" value="PHQ52103"/>
        <property type="gene ID" value="BLA24_09265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16183">
        <property type="protein sequence ID" value="PPT16183"/>
        <property type="gene ID" value="CYQ11_27875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304850" evidence="1">
        <location>
            <begin position="26"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="382" mass="40257" checksum="3EAE84AF3880F0E4" modified="2018-01-31" version="1">MRRFKRTLVAAALATTVMAGTAGWAAGGEQNAVTGPPPGTAAWRADRSLARPLPDPATARPAEVSRFFATLTEAGRHDLTARHSLVVGNLDGAPVALRYEANRWALTAERDKERARSTNSSLPSYERRRARELDERYTRLLRPGRQILAFDPRGRGQLAEVYGDWATARRTAVVVPGSDTDLASFDRDGRPDTPAGMARALREEMARQAPDTPAAVIAWAGYTTPVGVGLDAATGRLAQAGAPRLDRFLAGLAAAGTSAPPAVFCHSYGSVVCGLAAPELGSAEAADLVVLASPGVRAGSAAALRTGARVWAVRRNGADWIGRVPHVRLLGLGHGTDPTSASFGARPVASDGAHGHSGYFAPETRSLHNFARIALGRYDAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLJ1</accession>
    <name>A0A2G1XLJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isopenicillin N synthase family oxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09440</name>
        <name evidence="6" type="ORF">CYQ11_28050</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52134">
        <property type="protein sequence ID" value="PHQ52134"/>
        <property type="gene ID" value="BLA24_09440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16214">
        <property type="protein sequence ID" value="PPT16214"/>
        <property type="gene ID" value="CYQ11_28050"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00017"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="338" mass="36983" checksum="6CEC91B6F5C22977" modified="2018-01-31" version="1">MTNELPVLDLSAAHAGPKARARFHEALHTAARDVGFFHLTGHGITPAETAELTSAMRAFFALPEADRLAISNLNSPHFRGYTRIGDERTGGSQDWRDQLDIGAERPAHVPAPDEPGYWWLEGPNQWPAGLPELRTTALHWIDRLSEVAGRLLHELLAAIGAPEDFYDEAFADRPHLHLKLVRYPGSAPDGAGQGVGAHKDYGFLTLLLQDEVGGLQVESPDGTFIDVPPLPGAFVINLGELLEVATNGYLKATNHRVVSPPGTRERYSVPFFYNPRLDARIEPVSFPYAHRAPGVTQDAANPLFAEYGRNEIKGWLRAHPGVARRHHAALLEEGAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLL8</accession>
    <name>A0A2G1XLL8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_09285</name>
        <name evidence="12" type="ORF">CYQ11_27895</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52106">
        <property type="protein sequence ID" value="PHQ52106"/>
        <property type="gene ID" value="BLA24_09285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16186">
        <property type="protein sequence ID" value="PPT16186"/>
        <property type="gene ID" value="CYQ11_27895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304771" evidence="9">
        <location>
            <begin position="43"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="44"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="34044" checksum="8ED5F7C8531612EB" modified="2018-01-31" version="1">MEHCGGSVETRSSRAAARRWGAALTASAAAVAAALPTTTAEAAAGPAGITAKGAYLLDGGADRTLWQKDAQTKRPMASTTKIMTAVVVLDEHADDLNTRVTVKQSYRDWVTRKQASTADLRTGDQLTVRQLLYALMLPSGCDAAYALADTFGDGETEQERTGSFIDKMNDKARELGLNNTHYDSFDGNSARGANYTTPRDLAELAKHALRKNELLKVVKSTSTQQKAANVNRLYSWYNTNKLLGSYRGVIGVKTGSTSSAGPCLVFAAQREGRTVVGVILNDPAGRYPDAARMLDYAYHVRTPLTLRRLPSGAHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLW1</accession>
    <name>A0A2G1XLW1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52254">
        <property type="protein sequence ID" value="PHQ52254"/>
        <property type="gene ID" value="BLA24_08835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013968514" evidence="2">
        <location>
            <begin position="30"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="213" mass="21478" checksum="5C215ECA4CCAE0DE" modified="2018-01-31" version="1">MAVAMTAAVGCVSVSPSTGPSGPPPRSSAADPRARQNPARESLARVGDGPDDSRPPDASGPALSLTRDPDGRPLVDPSWDPWGAWAAGGSARNGGNPAGPPGFPGSPDRSHPGHHAPGSPRPAAPPAVSAPASDGPVREAAPAAPAPRHEAPPPPEHRHSEPRPAPEPREAPPAPAPVPRGRQGKGVCAMGDTYGKWQPGGDASRICHQVYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY4</accession>
    <name>A0A2G1XLY4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08790</name>
        <name evidence="2" type="ORF">CYQ11_04050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52248">
        <property type="protein sequence ID" value="PHQ52248"/>
        <property type="gene ID" value="BLA24_08790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12181">
        <property type="protein sequence ID" value="PPT12181"/>
        <property type="gene ID" value="CYQ11_04050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="119" mass="12828" checksum="A327301F455E4745" modified="2018-01-31" version="1">MSKAGKAWDPGNPDRLYIVTSGRAQAGERARLDLVTLVVARSKSDPGLQPEHSAIVQMCDYPLSIAEISAYLTLPVSTVTVLVTDLLKEDQVEARPPVPVATLPNVQLLEAVMHGLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM32</accession>
    <name>A0A2G1XM32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07620</name>
        <name evidence="2" type="ORF">CYQ11_00050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52324">
        <property type="protein sequence ID" value="PHQ52324"/>
        <property type="gene ID" value="BLA24_07620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11527">
        <property type="protein sequence ID" value="PPT11527"/>
        <property type="gene ID" value="CYQ11_00050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="564" mass="63743" checksum="276EFB118ED5F7B0" modified="2018-01-31" version="1">MRRADLLFSTLVVVAMTYSSGSWDDLPEEARPDGYLAPLTATPTEWVTVLGKPVHDRFDWGISSYLTRPAAREHALREYTWSQAAIGAAGISTVYPEQRTVFEEGLRDEEEHAEFFVQLRTHHGLAEPTLEFTPSFLWYFDAIPRNDGSWYYLDDAGRDHELVRTRRTDTELRFDIAAMPLRRYLAARSRLLVIQHDRIIRLDHVPDPAIDAIDRSDLRHFAFHSGDIHSVDRPGFVRLVGKQIVLPIEAEPADLARPHTSERRFPEFTVAIDPNTGERITSMCEPDKLSNYFTDRGTPHYLTRVYFRREVLNRYTSQPSRYRIENGRLSCLGLWGISIGTNPDGFIEVYLGDLGRDLPAEERDHWLSFNVPPSGGRDEGRFDRDILGRWTDGPPDPLRRLFAAREHFSTAMGTLLGQAVYKPWHPADQIAFEGLHMPTSSEQHEADTLILLLAKGVIDYLNVKALRRLPGVTDSKAQSINCLEAWVSSSGGDSDALIRPLRVLQGLRSTGPAHLRGKDWHATLTRAGLDALRPDEQFVQVLTLTGDALSALAQHAESQHQASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM60</accession>
    <name>A0A2G1XM60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08615</name>
        <name evidence="3" type="ORF">CYQ11_03870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52219">
        <property type="protein sequence ID" value="PHQ52219"/>
        <property type="gene ID" value="BLA24_08615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12152">
        <property type="protein sequence ID" value="PPT12152"/>
        <property type="gene ID" value="CYQ11_03870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="198"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="345" mass="38250" checksum="C99F97A05900D7D4" modified="2018-01-31" version="1">MIVWLNGAFSGGKTSAARELAELVPDSNLYDPEVTGGALRHLLPPKRRGEVDDYQDLPIWRRMVVDTAAALLAELGGVLIVPMTLLRQEYRDEVFGGLAARRIRVRHILLNTDETILRQRIEGRVEFADDPARSESVRQWARDHVQPYREALPWLTADAFGVDNSRLTPRETAERVAEAIRTGTAGVCPIVQTPEPTAETLASGVLLFDEHDRVLLVDPTYKPGWEFPGGVVEPGEAPARAGMREVAEEIGIELTSVPRLLVVDWEPPKPPGFGGLRFLFDGGRLNTADAERLLLPGAELRGWRFVTEDEASTMLPPVRLNRLRWALRARERGMPLNLEGGVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM91</accession>
    <name>A0A2G1XM91_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxyurea phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07680</name>
        <name evidence="2" type="ORF">CYQ11_00110</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52330">
        <property type="protein sequence ID" value="PHQ52330"/>
        <property type="gene ID" value="BLA24_07680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11534">
        <property type="protein sequence ID" value="PPT11534"/>
        <property type="gene ID" value="CYQ11_00110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="33870" checksum="399C7539E85E1881" modified="2018-01-31" version="1">MSSPQSIEVPDALVASYTRNGGEEERTWIARLPALVAELLDRWDLERDGGIKSGEASLVILVRRTDDTRAALKLQMPREETTAALIGLRAWNGNGIVRLLDHDPESSAVLLERLDGSRTLASVEDDDVAMNALAGLMARLHSAPTPEGLRGLGDIARDMLASVPAAVAALPDLQDQRRLHGWASAVTELVDEPGDRMLHWDLHYDNVLAASREPWLAIDPEPLVGDPGFDLWPALDTGWEKPHATGDTPRLVRRRFDLLTERLGLDRQRAAGWTLARLLQNTLWDIEDGRTSIDPSQTTVAQALPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMW6</accession>
    <name>A0A2G1XMW6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52587">
        <property type="protein sequence ID" value="PHQ52587"/>
        <property type="gene ID" value="BLA24_07410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="98" mass="10307" checksum="D63D3E132236C0BF" modified="2018-01-31" version="1">MSAAPAGVAEGPWPGSRPGPFRTRADTVVPGLVPAGRTARGLRARMLREDVAAERRLFWKELAALLVIALVVALMACLCEPVAAPAQPTGPFGSLYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMZ9</accession>
    <name>A0A2G1XMZ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="8" type="ORF">BLA24_06395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000079">
        <property type="protein sequence ID" value="PHQ52634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52634">
        <property type="protein sequence ID" value="PHQ52634"/>
        <property type="gene ID" value="BLA24_06395"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013854459" description="Polyamine aminopropyltransferase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="317" mass="34237" checksum="207B05EF1631EA0D" modified="2018-01-31" version="1">MTVRALWLLVAVNALVLALLGVCSALTGPFERAARQAVYGAEVKVAVHSDVQEVVLTGGGASGQPLSLFLDGRLRVSGNDDCRYHEALVHPAMAGPHRRVLVLGGGDGLAVREVLRYPDVASVTVVEEDAAVLRLARADRDLVALNGAAYRDPRVRVVTADAFDWLRSSRGQEAGPYDVVVSDLPDPGVTPSAKLYSQEFYGLVTRSLAPGGRLAIHGGDLSARPHTFWTVDATVRSVGLATEPYRVMAPPARDTRRQDWGLLLASRSPAPLRLPEARPALRTLTPHRLRRLAWAAERGRQPSPPPSTLMHPRYGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN63</accession>
    <name>A0A2G1XN63_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06160</name>
        <name evidence="2" type="ORF">CYQ11_03685</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52685">
        <property type="protein sequence ID" value="PHQ52685"/>
        <property type="gene ID" value="BLA24_06160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12119">
        <property type="protein sequence ID" value="PPT12119"/>
        <property type="gene ID" value="CYQ11_03685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="41258" checksum="E3D2F12EB340DA17" modified="2018-01-31" version="1">MSTDNDATARRPALVSPVSVTAGAVLHSADFIRPRLWDSGRTRLVLHAGVQINGTPHLGTNVMQTAAFLLAQEARERFGVPVLIRFGALDNAPYEVRACPDSGSLYERSFRNALGGPTVEDLAARYYGGLFDALSAATGVPYALETYTSQQSGRAFREEFLASLRQMDRLRWYLAPSTGTVPVSFPCPRCGWSQKYGEHTEVLTADAHEARFAAVCLDHGKYLVDVTADSDAFVGLTTLHRNLVKERVACRDDALPVIVKGADWAPGCRLLDEALQCCPDPVSPARLFTPVVLSDSGAKLSKTLIREGTADLSAETEPWMLDASRWAGTDEEYGRMLLDLVTRMLSEPRHFERGYTTREIARLIGRTPATRSAGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN67</accession>
    <name>A0A2G1XN67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">D-alanine--poly(Phosphoribitol) ligase subunit DltA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_06205</name>
        <name evidence="10" type="ORF">CYQ11_03730</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52694">
        <property type="protein sequence ID" value="PHQ52694"/>
        <property type="gene ID" value="BLA24_06205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12128">
        <property type="protein sequence ID" value="PPT12128"/>
        <property type="gene ID" value="CYQ11_03730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="974"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2058"/>
            <end position="2133"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3535"/>
            <end position="3610"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1009"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2093"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="3857" mass="410172" checksum="7CC77DB3ED86694E" modified="2018-01-31" version="1">MIPLSFAQRRLWFLGELEGPNPTYNIPAALRLAGELDRRALHDALRDVVERHEVLRTVFPAVDGTPRQRILPMDSVALELPVAEVAETDLDEALAHAAALPFDLSCDVPLRARLYALAPDEHVLLLVMHHIASDGWSMGLLARDVSVAYAARCRGEAPAWEPLPVQYADYTLWQLDLLGDENDPESVLAEQLAYWRAALAGLPEDLALPADRPRPAAVTHRGDTVGLRLGADLHRRLTELARTRGVTPFMVLQAGLAVLLSRLGAGTDIPLGTPVAGRMDDALDDLVGFFVNSLVLRTDVSGDPAFTELLARVRETDLGAFGHQDVPFERLVEDLAPTRSMARHPLFQVMLALQNNAEAVLDLPGLKVTALPGGDAPAKFDLSFALAEEFDAQGSPAGLTGSVTYAADLFDRASVEMITERFVRVLETVTADPAVTVSQVDVLSEPERARILGEWNATGRDVPAGTLPELFEAQVARTPEATALVFDDVELTYAELNARANRLARVLAEHGVGPESLVAVSMERSVELVVALLAVLKAGGAYVPVDPEYPAERIAYVLDDARPTLVLATGRPGDALSVPCLLLDDPEFVAHMASRPAGDLSASERHTALLPSHPAYVIYTSGSTGRPKGVVVPHEGVVNRLAWMQGEFGLGASDRVLQKTPFGFDVSVWEFFWPLVEGAVLVVARPGGHRDPAYLAGLVQAQGVTVVHFVPSMLQIFLREPAAASCGGLRAVFCSGEALSAELRDQFLGMLDVPLHNLYGPTEASVDVTAWSCAAGEGPVVPIGRPVWNTRVFVLDAMLQPVPVGSVGELYLAGVQLARGYLGRAGLSAERFVACPFGAPGERMYRTGDVVRWRADGSLEYLSRADDQVKIRGFRIELGEIETVLAAHPMVDHTAVVVREDAPGDKRLVAYVVPAAPDGVDAGVLRAHVASSLPEYMVPAAVVALDALPVTVNGKLDRRALPAPDYASTATGRGPASVQEEILCGVFAEVLGLPHVGVDDNFFELGGHSLLAVSLVERLRARGVPVSVRSLFTAPTVAGLAAAAAGRGEVVVPRNLIPADTPVITPEMLPLVDLTAAEIERVTAGVPGGAANVADVYPLAPLQEGLFFHHLVGGENGKDVYLQQTVLTFDSRERLDRFVDALQKVVDRHDILRTAFAWEGLREPVQVVARRAALPVEEVDLGPDTPADAAGRLLGACSPAMDIGRAPLLRAYVAADPGSGGRWLMVLQNHHLIQDHTTIDVLLEEVCALLLGHGDRLPEPVPFREFVAQARLGVSREEHERFFTRLLGDVDEPTAPFGVLDVHGDGADVRESRATMDTVLAERLRTQARRLGVSPATLFHVVWARVVAATSGRDDVVFGSVMFGRMQAGSGADRTPGLFINTLPVRVATGRTSVTDAVRAMQAQLADLLVHEHAPLTLAQQASALPADTPLFTSLLNYRHDGSGGDGSREDLQTGLDGIRLLSAHERTNYPLAVSVDDMGTGFGVVAQATASIDAETVCGLVLAVAEGVVTALEEGAAAPLDQVRGLGEAERTKILHEWNDTACEESVRTLPELFETRAADSPDAVALVHDGEELTYAELDARANRLAGLLAARGAGPERIVAVALPRSADMVVAVLAVLKSGAAYLPIDPAHPADRIAYVLADARPALLLTTNAVARGLPAGEGIERLLLDEAGAAAETPGGAPLRPCPPTHPAYVIYTSGSTGRPKGVVVSHRSAGAFAARIASAYGIGAGDRVLGLAAFTFDVSVFELFATLVSGAALVLVGDDDRLSAEGLQALMAERAVTVAEIPPALLPLLSADGLPALRLVSTGGDAPVGALVDQWAVDGREFWNGYGPTETTVAVTLMRCVPPSGGVAPPIGRPLPGTRVYVLDAALQPVPVGVVGELYVAGEQLARGYLHRPGLSAERFVACPFGGPGERMYRTGDLVRWNADGDLEFAGRADDQVKIRGFRIELGEVEAALLSHSSVGQAAVVAREDAPGDKRLVAYVVPAAEESGPDGGPVGTDTVVLREHVAASLPEYMVPSAVVVLDALPVTTNGKLDRRALPAPDLAVQPAGRAPRTPVEEVLASLFAEVLGLPRIGVDDNFFARGGHSLLGVRLVSRIRSVMGVETGVRALFEAPTVAALAERLAGAGTARSALTRRARPEAVPLSFAQRRLWFLGELEGPNATYNLPVAVRLTGALDHVALRAALGDLIERHEALRTVFPVVDGQPRQHVLAPEAAVCELTTVQVEPDGLPEAMTGAAAHTFDLSTEIPVRAWLFTVRPDEHVVLVVTHHIASDGWSMAPLARDLSTAYAARTRSEAPAWEPLPVQYADYALWQRELLGDEDDPDSVLSQQLAYWRQALADVPEELTLPFDRPRPAVATHRGASVDLAVPADLHARLVELARAHGVTVFMTLQAATAVLVSRLGAGTDVPIGSPVAGRTDEALDDLVGFFVNTLVIRTDLSGDPSFGELLGRVREAGLGAYAHQDVPFDRLVEDLAPTRSMARQPLFQIMLALQNNADASLDFAGLRAEALSSGHVSAKFDLEIGLSERFGADAEPAGLHGGIIYATDLFDRATVEEFARRLLRVLDTVTADPGQHLSQVRILGGAEREQILHGWNDTGHEVPAATLPDLLRARAEECPDATAVVFEDTVLTYAELEGRANRLARLLRSHGAGPETLVAVCMERSAELVVALLAVLKTGGAYVPLDPEYPAERIAYVLDDARPAVVLTSRAARAGLPAEGPLPVVLDEPDTLEELAALDGTPPSGGEPLPAHPAYVIYTSGSTGRPKGVAVPHQALTNFVAAMGSRLALDAADRLLAVTTVAFDIHVLELYVPLLAGAGVVVAGRPAVRDPRALADLVDRHGVTIMQATPTLWQALLAEHAEAVRGLRVLVGGEALPPALAARMAEAAGEVTNLYGPTEATVWATVAALGTDGDGTPPHPVPPIGRPLWNTRTFVLDSALQPVPVGVAGELYLAGVQLARGYLGRPALSAERFVACPFGAPGERMYRTGDLVRRRADGSLEYLSRVDDQVKVRGFRIELGEIESRLAAHDEVAQAAVVAREDGRGAQQLVAYVVPAGRSAAGRDQESEGRQVEEWHTVYDSLYREVAQEDDAGFGENFAVWTSAYDGGRIPLAHMREWRSTTVERIREHHPRRVLELGVGNGLILAHLAPHCDEYWGTDFSAEAVDALREGVSRRPELRDKVRLRTQAADVVDGLPQGHFDTVVVNSVVQYFPNADYLAEVLRKAVALLAPGGRVFVGDVRNLRLQRCLATAVELHRHQPGKGLDAVRRAVEQALVTEKELLVDPEFFTALSAGDPAVDGVDVLVKRGLHHNELTRHRYDVVLHKAPSGRATAAEESVLRWGADVADTGALAGLLAERPAALRVTGVPHAGLAGEVAALRGLDAGADEATVLAALHGGGPGVDAEELYRLGERLGYRTAVTWSRGSDDGAMDALFVDPAAAGAGRAAPAHRSVGAPTGDLAAWTSNPVAGRAGATLAASLRAHLLERLPDYMVPSAVVLLDALPQTANGKLDRRALPAPEHAAAASGRAPATAQEEILCGLFAEVLGLPRVGVDDSFFELGGHSLLGVRLAGRIRSVLGAEVTIRTLFEAPTVAALAERLADAGLTKEALGVLLPLRTQGGRAPFFCVHPAGGASWCYAPLSRYVPADQPLYGIQARGLDGGQEALPYSVRDMAADYVAQIRTVQESGPYHLLGWSFGGIVAQEMAVQLQADGHEVAALVLMDVYPTEPEEAASEEGTGHPDVSDVVVQRAGRFGVELSEEEVGRFGRVILNNARIQRAHTPGGFDGDLLLITAEDEEPQAGGTAERWRPHVSGAIAESGLPCVHDDMAQPDMLSRVWSTVSEWMSSNRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN84</accession>
    <name>A0A2G1XN84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_05355</name>
        <name evidence="7" type="ORF">CYQ11_01815</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52705">
        <property type="protein sequence ID" value="PHQ52705"/>
        <property type="gene ID" value="BLA24_05355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11798">
        <property type="protein sequence ID" value="PPT11798"/>
        <property type="gene ID" value="CYQ11_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="24707" checksum="CD03C7EB3326E6CD" modified="2018-01-31" version="1">MTNAPTRILLADDQDDVRSGFRLVLDSQPDMTVVGEAADGATALDLASRLRPDVVLADIRMPHLDGLELTRRLAGPGSACPTRVIVVTTFDLDDYVHTALHNGASGFLLKRSGPALLIEGVRAAMAGDALISPQITVRLLRRLTATPSPRPAAGPPGGTPPDPLTDREREIVRLIARGHTNARIAAELFISPGTAKTHIANIQTKLKTGNRVGIAAWAWKTGLATPEPYDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNA6</accession>
    <name>A0A2G1XNA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05485</name>
        <name evidence="4" type="ORF">CYQ11_01945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52727">
        <property type="protein sequence ID" value="PHQ52727"/>
        <property type="gene ID" value="BLA24_05485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11821">
        <property type="protein sequence ID" value="PPT11821"/>
        <property type="gene ID" value="CYQ11_01945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="665"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="866" mass="92825" checksum="415F3D5C19A1BDF4" modified="2018-01-31" version="1">MAGPERHEGTSRALLVGVAHYANKRPLRFAAGLGDIAAVQQNLDELRDVLGTGGVFDEDRIEALSSPGVEQFENRLGHARDHTDQLLLVYFAGHGIVDTRTGGHGRLLLGLRDAKVEHGPGFPGWIRWDDVLNRLCSGENRPRHTVVVLDCCYAGNASAAWEELDEQDQQRVSLLLAVQKNQRIDAGNARTPTPYTAHLIRHLGRGARPAGGPVTLGGLHKRVSDDLKALKTVGGREWNPQACRKDSADDEVLARPPGGGPLPPATGGSQGTGEEHPGPRPRPARLITAALLAVTAALTAAFWWITSGDSDGDGPSASCAHHAPLELRVLTDPDLAPVIRKAADGFVASDANRDGDNCRRTGVTVYSAGAADTVEAFRTQYGEWAHVGRSGFNPMSTVGPQPDVWIPASSASARRAQDEGGNQSSVLTLDFDGERPLAYAPMVLLLPERLAEPEGARAGRKLADLLTAMKGKGEQTEVRRADPRNTDAALAAARGLYQTDAPRNVELGQRRQGRTAPTGKDLVCGLAGGSSAEARAVDRRTAVLVAEPTLGAYQHCVGETGVTRVAEYPTDVPGLAPVFVHVRWNDARLDEGERDQAVQRFRDWLTSEDGRKAFQDQAFRQGSRAPFSSASPGVLTSPGPVPRALSADEASDTLEKYRQANAASRVRFLLDSSGSMSRWWDGANSTREILKQSLSRFGSEDIFGVWSVASAGSGAPYRELLPFGTHGSWSRAADKSEQDKAAEAGRKVDDAVPEPSQEADIGGALREALNQMPRGDEDDGHPQLIVLLTDDEDNDRMNAARQDDLVTFVRGRNVPVVMVSFDSGGCLKDRLDLRLAEASGGRCLDARGDLARDLAAEISQVAQGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNF8</accession>
    <name>A0A2G1XNF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05745</name>
        <name evidence="3" type="ORF">CYQ11_02220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52768">
        <property type="protein sequence ID" value="PHQ52768"/>
        <property type="gene ID" value="BLA24_05745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11869">
        <property type="protein sequence ID" value="PPT11869"/>
        <property type="gene ID" value="CYQ11_02220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="339" mass="35810" checksum="119219BC44BE7388" modified="2018-01-31" version="1">MIDLLVAGGGPAGLAAAIHAARAGMETVVVEPRGAPVDKACGEGIMPGGVTALAGLGVEVSGRELRGIRYVEGARRVEASFRHQAGLGVRRTELHAALHRRARELGVRIVPERAGEVRQHADGVTVGGRTARWLVAADGLHSPVCRSLGLDVAGGARPVRYGLRRHYRIRPWTDFVEVHWSRRGEAYVTPVGEELVGVALLGHGRGGGYEERMAAFPALAHLLSGVPAGAVRGAGPLRRRTRRKVAGRVLLVGDAAGYVDALTGEGIALALATAGAAVHCLTAGRPDAYEAAWYRLTRRHRVLTECLVRACEHPRAAGLIVPAACRLPRLFSAAVHALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNL9</accession>
    <name>A0A2G1XNL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_04585</name>
        <name evidence="7" type="ORF">CYQ11_28945</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52855">
        <property type="protein sequence ID" value="PHQ52855"/>
        <property type="gene ID" value="BLA24_04585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11489">
        <property type="protein sequence ID" value="PPT11489"/>
        <property type="gene ID" value="CYQ11_28945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="29113" checksum="8CFEAA1E4C5364CB" modified="2018-01-31" version="1">MTLLSVNDLTVSFRSGVRAVDGVSLELDAGRTLGVVGESGSGKSVTSLAVLGLLPASATVGGSVRFDGRELLGLDRGALRRLRGDRIAMVFQDPLSCLNPYYTVGFQIAEAHRAHRRTSRRAAREVAVRMLERVGIPEAGRRARHYPHEFSGGMRQRVMIAMALCLEPDLLIADEPTTALDVTVQAQILQLLRDLREESGTAVLLITHDMGVVAGMADDVSVMNGGRVVEHGPVREVFGRPADPYTRGLLACVPRVDGPVPRRLATVEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN5</accession>
    <name>A0A2G1XNN5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05790</name>
        <name evidence="3" type="ORF">CYQ11_02265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52826">
        <property type="protein sequence ID" value="PHQ52826"/>
        <property type="gene ID" value="BLA24_05790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16301">
        <property type="protein sequence ID" value="PPT16301"/>
        <property type="gene ID" value="CYQ11_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="20024" checksum="0DEAE51D6895A76F" modified="2018-01-31" version="1">MPAAILLLLAAAARSGVAERTEAFLDFGAGVLALVSLTATVLWGLAATDRMLLGSAHRLLAQGVHRGLAVAGLGFLALHVWVKVAEGHTSGAAVAVPFTDPASPLLIGLGTLAGYLFVTVAVTGAVRSTFASVGRSRAWRALHMSAYPAWGGALVHGLHSGRPASGWVTAAYALCLAGVAAALVLRLRRARGSEGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNZ6</accession>
    <name>A0A2G1XNZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04755</name>
        <name evidence="4" type="ORF">CYQ11_28780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52879">
        <property type="protein sequence ID" value="PHQ52879"/>
        <property type="gene ID" value="BLA24_04755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11462">
        <property type="protein sequence ID" value="PPT11462"/>
        <property type="gene ID" value="CYQ11_28780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7144" checksum="0A267EBE0DFAE070" modified="2018-01-31" version="1">MSDAGPPLPQRRIALVDLLDRLLAGGVVITGDLTLRIADVDLVRIDLRALVSSIDARVPAPWEETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP33</accession>
    <name>A0A2G1XP33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05035</name>
        <name evidence="3" type="ORF">CYQ11_28495</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52919">
        <property type="protein sequence ID" value="PHQ52919"/>
        <property type="gene ID" value="BLA24_05035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11420">
        <property type="protein sequence ID" value="PPT11420"/>
        <property type="gene ID" value="CYQ11_28495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="595" mass="66994" checksum="0F04406C0429DFE4" modified="2018-01-31" version="1">MATAQDSDAARSDLTEVAFDPITRIIGNLGIYTKIDFPGRKVVECRSTSSIFRGYSVFMKGKDPRDAHFITSRICGICGDNHATCSVYAQNMAYGIKPPPLADWIINLGEAAEFMFDHTIFQDNLVFVDFCERMVKETNPSVLERAERTPAPRGDLHGFKTIADIMRAFNPFEGQVYKEALQMSRLTREMCCLMEGRHVHPSTLYPGGVGTVATPQLFTDYLVRLTRCLDFVKRAVALNDDVFDFFYEALPGYDQVGRRRTLLGCWGCFQDPDVVDYDYRNMTEWGNAMFVTPGIVVDNELVTTDLVDINLGLRVLLGSSYYEDWAGEETYVDKDPLGNPVDQRHPWNQTTLPRPQKRDLDGGNYSWVMSPRWYDKRTGDHLALDTGGGPLARLWTTALAGKVRTPYVRSTGHSVEIDLPKTPATPETRLEWKPPPFPNTIERDRARMYFVAYAAGMALHFVERALEEVRAGHTKVFEDFKVPKEAIGVGFHEAVRGVLSHHLVIRDHKIANYHPYPPTPWNASPRDRYGTPGPYEDAVQGMPIFEENGPDGFKGIDIMRTVRSFDPCLPCGVHMYLGDGRTVRQSHSPTLGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP43</accession>
    <name>A0A2G1XP43_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetic acid degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04465</name>
        <name evidence="1" type="ORF">BLA24_14030</name>
        <name evidence="3" type="ORF">CYQ11_01725</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51457">
        <property type="protein sequence ID" value="PHQ51457"/>
        <property type="gene ID" value="BLA24_14030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52961">
        <property type="protein sequence ID" value="PHQ52961"/>
        <property type="gene ID" value="BLA24_04465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16287">
        <property type="protein sequence ID" value="PPT16287"/>
        <property type="gene ID" value="CYQ11_01725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="25064" checksum="3D83DB53EA16C632" modified="2018-01-31" version="1">MPEEYREIAVRQMMVNTEGELSGGDDYIQVFLPLAPNAEERQVCAERAVEEYDHYKIGKAVLAGVGVDTGYMEKQTLAERNLFADQTLHTCTTWAERGIFSYIGEETAMVMISEFAHSSYKPWAEAVRTIILDEKIHIAHGARVCRNLARTEEGHHELQQALDRLWPTFVKIFGSPRSERSRLAVRFGLRRTTNGQACDVWREKVLPRVERLGLRNPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPK7</accession>
    <name>A0A2G1XPK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02205</name>
        <name evidence="4" type="ORF">CYQ11_04565</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53174">
        <property type="protein sequence ID" value="PHQ53174"/>
        <property type="gene ID" value="BLA24_02205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12266">
        <property type="protein sequence ID" value="PPT12266"/>
        <property type="gene ID" value="CYQ11_04565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="379" mass="40068" checksum="4DC3B20DD7348844" modified="2018-01-31" version="1">MSRRLPLALVLAYLAAVVCIDLMTPAYLRLDVYAALAPVTAAAICTYRQTVFVGIADFLLMAAHHGVMPGEASLVNRVGAVLGNLLIVGASIVMARLRRDGEALLERVRATGEAAQRALLRPLPLRTHSVVVDGFYVSSQREALIGGDIYEVVDTPYGTRVLIGDVRGKGLGTLGAGAAVLTAFREAAYHRRDLGSGVVAMEQGLHRYHRSAEYQERARNGHAAEEFVTALVLGTEEDPAASAGAPGRIPVVFVDCGHPAPFLIGADGGVRELQTEEPGLPLGLGDLVDQPRPVQRVVLPPDSRVLACTDGVTEARAPDGGFYPLAERLDAWAALPTPELLGRLRADLAAHTGGRLQDDVAVLVVERASGPPARPEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPZ5</accession>
    <name>A0A2G1XPZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_03150</name>
        <name evidence="8" type="ORF">CYQ11_05450</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53315">
        <property type="protein sequence ID" value="PHQ53315"/>
        <property type="gene ID" value="BLA24_03150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12412">
        <property type="protein sequence ID" value="PPT12412"/>
        <property type="gene ID" value="CYQ11_05450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="523" mass="53369" checksum="550D83DE7191821E" modified="2018-01-31" version="1">MSGGTGTTSPGARAPHEAEAPRPGRWLALAVLALAVLLVAVDATVLGLATPYLSEDLQPTGTQLLWIGDIYSFVIAGLLVSMGSLGDRIGRKRLLLSGAVAFGAVSVLNAYATSPEMMIAARALLGVAGATLMPSTLALIRNLFHDPRERSLAIGIWGAMASAGAAVGPVVGGFLLENYWWGSVFLINLPVMAVLVLVGIKLLPESRDPAPGPWDLLSVALSMIGIVALVYAIKEGATHGFTWPIAVASAVGLLALVWFVRRQLKLPAPLLDMRLFHHGGFSGAVMADLLTVLGLSGLVFFLSQFLQLVQDRSPLEAGLAELPAAIGAVTAGLLAGQAARRFSVRSVVAGGLAAIGVSLAVLVGLSSDTAYPVLGTVLLVVGIGAGFSFTVTADVILSSVPKEQAGSASAVSETAYELGAALGIAVLGSIVTGVYRDFTVPQGVPAQAAAEAHESLGGAVETTTQLPADTGAALLASAQDAFVDGLRIASGVGAVVLLGTAVAAWFLLRGQQLEEGYGGPTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ31</accession>
    <name>A0A2G1XQ31_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">BLA24_03180</name>
        <name evidence="5" type="ORF">CYQ11_05480</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53320">
        <property type="protein sequence ID" value="PHQ53320"/>
        <property type="gene ID" value="BLA24_03180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12417">
        <property type="protein sequence ID" value="PPT12417"/>
        <property type="gene ID" value="CYQ11_05480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="401" mass="41709" checksum="1FA3B0F3B57A4826" modified="2018-01-31" version="1">MTNADLTRRWQGALMDNYGTPRVPLVRGEGTAVWDADGKRYADFVGGIAVNALGHAHPAIVRAVSDQIATLGHVSNLFTAEPTVLLAERLLRLAGRPGRVYFSNSGAEAVEAAFKIGRRTGRTHMVATQGGFHGRTMGALALTGQPAKQEPFLPLPGDVTHVPYGDAEALRAAVTTDTALVVLEPVQGENGVVVPPPGYLTAAREITRATGTLLVLDEIQTGIGRTGHWFEHLAQGVEPDVVTLAKGLGGGLPIGATLAFGPAADLLTPGQHGSTFGGNPVSCAAALAVLDTIEADGILDRVKHTGELLRDGIAALAHPLVDHVRGAGLLLGIVLAEPLAPKVQQAAQEAGVLVNAVAPHVVRLAPPLIITEDEVETFLQTLPGVLDAVADGTHEERRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQA2</accession>
    <name>A0A2G1XQA2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000029">
        <property type="protein sequence ID" value="PHQ53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53371">
        <property type="protein sequence ID" value="PHQ53371"/>
        <property type="gene ID" value="BLA24_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="82" mass="9385" checksum="A59B526F7F8C4210" modified="2018-01-31" version="1">MGIYLDPQRGAITLRAWAKDWLDRQILAEGTMRNYEGFTKNHLVPHLGRKTLAGLARADFERFIAACTARARAWRPRRSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQB9</accession>
    <name>A0A2G1XQB9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_02580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53339">
        <property type="protein sequence ID" value="PHQ53339"/>
        <property type="gene ID" value="BLA24_02580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="355" mass="37660" checksum="0BF6B29410FA9EF3" modified="2018-01-31" version="1">MTAVQLRSRLEELTGLRLGATLLFDHPTPTALATELHDRLSAQAATEAESPETGEVSAAPGPLGALYRRACAEEKLDEALELLKAASLLEGTFSAHDAELPVSRPIRLSSVTSSGTDGESGTDGESEPTLICFPSFSPVAGPHEYARFAAHFRGTADVWALPEPGFLSGESLPGTVEALARVHADAVLRCLGDGGTRRRFVLAGRSAGGWVAHAVARRLEELGHAPSAVVLLDTSSPAHMAQSPVGAQIGGAMVSRENDFDMFDDRRLAAMGGYIRIFSQWDVEPVAAPTLLVRASACFSAGEGEDSGPAAPPEDWRAVWELADCEVDVQGDHFTMLEDFSDSTAEAVRTWILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQS7</accession>
    <name>A0A2G1XQS7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00035</name>
        <name evidence="2" type="ORF">BLA24_20385</name>
        <name evidence="4" type="ORF">CYQ11_10400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000002">
        <property type="protein sequence ID" value="PHQ53597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50379">
        <property type="protein sequence ID" value="PHQ50379"/>
        <property type="gene ID" value="BLA24_20385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53597">
        <property type="protein sequence ID" value="PHQ53597"/>
        <property type="gene ID" value="BLA24_00035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16472">
        <property type="protein sequence ID" value="PPT16472"/>
        <property type="gene ID" value="CYQ11_10400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="173" mass="19079" checksum="C78EBF3821D45FCA" modified="2018-01-31" version="1">MDDVDDALKIVGDDRVTTWLSFDSRDRQGTQEMLEGAISRAQREPRDEYYLAIVAPPSDHVIGFCRIGLSGVRAGKLGYAVAASEWGKGYATDAARTMIDFGFRTLGLHRISAAIGPDNLASINLIERLGFTREGVLRDHVHTNGVWRDSILFSTLAKEWPESQSEGPKTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9N1</accession>
    <name>A0A2G1X9N1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-containing redox enzyme family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Pyrroloquinoline quinone biosynthesis protein PqqC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31005</name>
        <name evidence="2" type="ORF">CYQ11_24105</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47931">
        <property type="protein sequence ID" value="PHQ47931"/>
        <property type="gene ID" value="BLA24_31005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15556">
        <property type="protein sequence ID" value="PPT15556"/>
        <property type="gene ID" value="CYQ11_24105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="252" mass="28417" checksum="F3710C582E4F1726" modified="2018-01-31" version="1">MSEFVAELDRMIVERKKMTSPLYQTIVSGKATARLLRTFVVQRWPIKNLWTRNILGIASRVDDHRLRSLLVENIYEEETGALSGSRRHLETFADFGRAVGVTREELEDTEPFPETTAVVEHNIGVCNDSEVHFTAGVASVLLLMEGQPPIVNASGSSMLTVMRDAYRLPDWGYEFFVHHASANEEADAVSELEDEHAAAARELLVRYCDTDELRAGAKKHLARALDLRHQHFDAILREAYSADEPVFRHQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9T9</accession>
    <name>A0A2G1X9T9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31495</name>
        <name evidence="2" type="ORF">CYQ11_24540</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47983">
        <property type="protein sequence ID" value="PHQ47983"/>
        <property type="gene ID" value="BLA24_31495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15608">
        <property type="protein sequence ID" value="PPT15608"/>
        <property type="gene ID" value="CYQ11_24540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="13489" checksum="3E5991A0DF95AEB9" modified="2018-01-31" version="1">MTVPLLVVDAANVVGSVPDGWWRDRRGAAERLRDRLAPRAREGLPPGTVTPPLPGPVEVVLVVEGAARGVGPVPGVRVEAAAGSGDDEVVAVVAGRVPGRRCVVVTADRELRERVTALGAEVVGPRSVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9V9</accession>
    <name>A0A2G1X9V9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31645</name>
        <name evidence="3" type="ORF">CYQ11_24700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48010">
        <property type="protein sequence ID" value="PHQ48010"/>
        <property type="gene ID" value="BLA24_31645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15636">
        <property type="protein sequence ID" value="PPT15636"/>
        <property type="gene ID" value="CYQ11_24700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="35644" checksum="7BD40AF3DB3B7B37" modified="2018-01-31" version="1">MFVALRDIRFARGRFALMGTVVALITTLVVFLYGLTGGLAREASSAVAALPADRIVFGAPAGAEPEVSFANSTLDERQGDAWRRAPGVASAEPLGVAMARLTAHGTATSVSVLGTAARLRPALLTGSAPDDAGVAVSERLAREKGLRVGDRVTLGTVELTVSGVTPDRGYGHAPTVWTTLAAWGRAAHQQQPTALAVRGGGGPTGAVARTTRAVALDDALDGIDGYAAEHGTLQLVQGFLFVVSALVVGAFFTVWTVQRRPDVAVLKAVGASSGYLLRDALGQAAAVLAAGAVLGGAAGVAGGALASRAVPFELGAETVAVPVAAMVLLGLAGSALAVRRITSVDPLTALGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA42</accession>
    <name>A0A2G1XA42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_32210</name>
        <name evidence="11" type="ORF">CYQ11_25265</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48104">
        <property type="protein sequence ID" value="PHQ48104"/>
        <property type="gene ID" value="BLA24_32210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15730">
        <property type="protein sequence ID" value="PPT15730"/>
        <property type="gene ID" value="CYQ11_25265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="92"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="288"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="497" mass="52817" checksum="67BBF853C00DC051" modified="2018-01-31" version="1">MNRTRINDRSARTRSGNPGSAMGGNRSGSPRRAEGPGRRRTSPQGEFALPKTVTSALPAVEAFADLDMPAQLLAALGHEGVTVPFPIQAATLPNSLAGRDVLGRGRTGSGKTLAFGLALLARTAGRRAEPRLPLALVLVPTRELAQQVTDALTPYARSVRLRLATVVGGMPIGRQAAGLRTGAEVVVATPGRLKDLIDRGDCRLDQVAVTVLDEADQMTDMGFMPQVTELLDQVRPDGQRMLFSATLDRNVDLLVRRYLTDPVVHSVDPSAGAVTTMEHHVLHVHGADKHRTTTEIAARDGRVIMFLDTKHAVDRLTEHLLNSGVRAASLHGGKSQPQRTKTLSRFKSGHVTVLVATNVAARGIHVDNLDLVVNVDPPSDHKDYLHRGGRTARAGESGSVVTLVTPQQRRAMSRLMAAAGITPQTTEVRSGEAELSRITGAQAPSGVPVTITAPATERPRRADSSSPRGRRGRVGRGRSAGGTGRRTAPRSSVDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA58</accession>
    <name>A0A2G1XA58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32145</name>
        <name evidence="3" type="ORF">CYQ11_25205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48095">
        <property type="protein sequence ID" value="PHQ48095"/>
        <property type="gene ID" value="BLA24_32145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15721">
        <property type="protein sequence ID" value="PPT15721"/>
        <property type="gene ID" value="CYQ11_25205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="226" mass="23973" checksum="2E71EA96FA5BB331" modified="2018-01-31" version="1">MDREGRTGRDGDDAARGPAGAGGNRLVPLIAAGSAPRAAVAALALEQHHVIPADRRSFRHLAERAAQGRQPAVAAFFAHLEQGEGVALERLGVLAAACGLDAETLRAHEPRAGCQAYPAYVAWLALGAEPVDVVVALSANFAAWGGYCATVAQALRRHYGFTDEACGFFDFFAEPDPRGAALAAEAGRAGRAEGLLTERLAHRYGRMLQEYESMFWNTLADTCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA77</accession>
    <name>A0A2G1XA77_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32340</name>
        <name evidence="4" type="ORF">CYQ11_25390</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48123">
        <property type="protein sequence ID" value="PHQ48123"/>
        <property type="gene ID" value="BLA24_32340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15749">
        <property type="protein sequence ID" value="PPT15749"/>
        <property type="gene ID" value="CYQ11_25390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304602" evidence="2">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="116" mass="11672" checksum="B961E547A5505194" modified="2018-01-31" version="1">MTHLRRRIALLAGAVLVAGAGATGAALATSHTAAPSAPVTHTMPAPRASDPADPGEDSTGPDRDNVQQGDQTAPDTGRAGQEQERRGEAPENGVSDGSGGHADPSGTVDHRFTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF4</accession>
    <name>A0A2G1XAF4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name evidence="2" type="ORF">BLA24_32890</name>
        <name evidence="3" type="ORF">CYQ11_25940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48216">
        <property type="protein sequence ID" value="PHQ48216"/>
        <property type="gene ID" value="BLA24_32890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15843">
        <property type="protein sequence ID" value="PPT15843"/>
        <property type="gene ID" value="CYQ11_25940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="25009" checksum="E4B3A7EF99D54728" modified="2018-01-31" version="1">MTDTPTPPPVTAVPPPGWPTTEAEAAAVQDRLRTRVVRDEAGPAPDAALVVAGVDVAYDDERDVVAAAAVALDAATLTVVAEATAVGRISFPYVPGLLAFREIPAALAALQGLAVAPDLVVCDGYGLAHPRRFGLASHLGVLTGLPTIGVAKNPFTFRHEAPGPRRGEWAPLLDGTEEVGRALRTQEGVKPVFVSVGHRVSLDHACAHVLRLAPRFRQPETTRAADALCRRALRAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP2</accession>
    <name>A0A2G1XAP2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_33370</name>
        <name evidence="5" type="ORF">CYQ11_26420</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48293">
        <property type="protein sequence ID" value="PHQ48293"/>
        <property type="gene ID" value="BLA24_33370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15924">
        <property type="protein sequence ID" value="PPT15924"/>
        <property type="gene ID" value="CYQ11_26420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="114"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="342" mass="37562" checksum="9C2ADF55550548BD" modified="2018-01-31" version="1">MTILDPAPPPPMRLRELVFGAACAAAIRAAARLGVADALGDTPMTAEDLAAAVETEPRTLRRLLRALSCQGVFKEEPDGTFAHTEMSRLLREDDPRSLRYIALWCTEPWTWDVWPRLDEAVRSGRNVFEDVYDREFFTYLNEDAPESAYVFNRAMTTSSEQSARDVAELLDLRGVTSVADIGGGQGHVLASLLEKHPGLDGVLFDLPAVVGNADPRLRDGGALASRVRIVPGDCREDLPVRADVYIIKNILEWDDDSTRRTLANIRKVARAGARVVVIENLVDDTPSMRFTTAMDLLLLLNVGGAKHTRQSMVDRLTGAGLVVGEIRPVNAYLHAFECTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB58</accession>
    <name>A0A2G1XB58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29330</name>
        <name evidence="7" type="ORF">CYQ11_06145</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48468">
        <property type="protein sequence ID" value="PHQ48468"/>
        <property type="gene ID" value="BLA24_29330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12534">
        <property type="protein sequence ID" value="PPT12534"/>
        <property type="gene ID" value="CYQ11_06145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="22209" checksum="797F6A687FADA18A" modified="2018-01-31" version="1">MAGTTENGGRPVPQRLLAAATRLFADQGYDRTSVQEIVEAAGVTKGALYHYFGSKDDLLHEVYGRVLRLQQERLDALAGTDAPVERRLRQAAADVVVTTIENLDDTKIFFRSMHHLAPEKLRQVRAERRRYHERFRALVEEGQRSGVFSRATPADLVVDYHFGSVHHLSSWYRPDGPLAAQEVADHLADLLLRALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB97</accession>
    <name>A0A2G1XB97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_29625</name>
        <name evidence="6" type="ORF">CYQ11_05850</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48517">
        <property type="protein sequence ID" value="PHQ48517"/>
        <property type="gene ID" value="BLA24_29625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12484">
        <property type="protein sequence ID" value="PPT12484"/>
        <property type="gene ID" value="CYQ11_05850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="223" mass="24094" checksum="23BA62D19C0D0A3C" modified="2018-01-31" version="1">MAIRVLLVDDQPLLRTGFRMILEAEQDLAVVGEAGDGLQALDQVRALQPDVVLMDIRMPRMDGVEATRQITGPERNGPAKVLVLTTFDLDEYVVEALRAGASGFLLKDAPAHELVQAIRVVAGGEAMLAPSITRRLLDKYAGHLPSGEEPLPDTLNTLTDREVEVLKLVARGLSNAEIAADLFVSETTVKTHVGHVLTKLGLRDRVQAAVYAYESGLVRPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBN7</accession>
    <name>A0A2G1XBN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">BLA24_28475</name>
        <name evidence="7" type="ORF">CYQ11_06995</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48653">
        <property type="protein sequence ID" value="PHQ48653"/>
        <property type="gene ID" value="BLA24_28475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12667">
        <property type="protein sequence ID" value="PPT12667"/>
        <property type="gene ID" value="CYQ11_06995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="254" mass="27559" checksum="B1FDA1E93B65B2C9" modified="2018-01-31" version="1">MATLEIHDLHVSVEAENGPREILKGVDLTVKQGETHAIMGPNGSGKSTLAYSLAGHPKYTITGGTVTLDGEDVLEMSVDERARAGVFLAMQYPVEVPGVSVSNFLRTSATAVRGEAPKLRTWVKEVKAAMEQLQMDPSFAERNVNEGFSGGEKKRHEILQLELLKPKIAILDETDSGLDVDALRVVSEGVNRVRETGEVGTLLITHYTRILRYIKPDFVHVFANGRVVESGGAELADKLENEGYEAYVKGGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBS6</accession>
    <name>A0A2G1XBS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28795</name>
        <name evidence="3" type="ORF">CYQ11_06670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48704">
        <property type="protein sequence ID" value="PHQ48704"/>
        <property type="gene ID" value="BLA24_28795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12615">
        <property type="protein sequence ID" value="PPT12615"/>
        <property type="gene ID" value="CYQ11_06670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="8190" checksum="13F09CDD292FD63F" modified="2018-01-31" version="1">MSAGRQAVHVPGGAQHRTQSRLPWWALALPLVAFATLFSLLAQPASADTGGGSSTGGVSRVVQFVRYFVDHTENWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBS8</accession>
    <name>A0A2G1XBS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28530</name>
        <name evidence="5" type="ORF">CYQ11_06940</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48661">
        <property type="protein sequence ID" value="PHQ48661"/>
        <property type="gene ID" value="BLA24_28530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12659">
        <property type="protein sequence ID" value="PPT12659"/>
        <property type="gene ID" value="CYQ11_06940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="348" mass="36799" checksum="29C437D65458E22E" modified="2018-01-31" version="1">MTVPFSVLDRSRTRQGREPGEALRDTVAFAREAEALGYHRFWVSEHHSVPGVAGSAPTVLAAAVAGATSRIRVGTGGVMLPNHRTLVVAEQFGVLESLFPGRIDMGLGRSVGFTDGIRRALGADKDAMGDFGAQLAELAAYFTDGPRPHPQVHARPAEGLRVPMFVLANESGAERAAEAGAALVIGGLKGEDAMLAAIERYRAAFRPSAGWPRPHVMVAGNVAVAETSEAARRLLVPEAWSLAYSRTHGVFPPLLAAEEIEELPMTEKERGFYEAGLRGHIHGTQEEVGAALAALVGRTGADEVLVTTSSFDRAALLDSYRRLAALAGPPERPRRVAAPAATAPAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC42</accession>
    <name>A0A2G1XC42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27185</name>
        <name evidence="3" type="ORF">CYQ11_18470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48765">
        <property type="protein sequence ID" value="PHQ48765"/>
        <property type="gene ID" value="BLA24_27185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14587">
        <property type="protein sequence ID" value="PPT14587"/>
        <property type="gene ID" value="CYQ11_18470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="169" mass="19135" checksum="5F36BA77DF2B45F4" modified="2018-01-31" version="1">MSGDAVDEIIGLWAEERPDLAERLWPVQVLGRLQRLGVTLDREFRAFAAARGLELGEFDVLNTLRRSGPPYELTAGDLKRAAMVTSGAITNRIDRVEAKGLVERVREAADRRVVKIRLTERGREITQAFMDDHLVNEARMLKDFDRAECDELSALLRRLLVSFGDTTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC82</accession>
    <name>A0A2G1XC82_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_27205</name>
        <name evidence="15" type="ORF">CYQ11_18450</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48769">
        <property type="protein sequence ID" value="PHQ48769"/>
        <property type="gene ID" value="BLA24_27205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14583">
        <property type="protein sequence ID" value="PPT14583"/>
        <property type="gene ID" value="CYQ11_18450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="9"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="309"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ48769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT14583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="45273" checksum="E895F26FD95A2946" modified="2018-01-31" version="1">MTKIKVAHPVVELDGDEMTRIIWQFIKDRLILPYLDVELKYFDLGIEHRDATNDQVTVDAANAIKQYGVGVKCATITPDEARVEEFGLKAMYRSPNGTIRNILGGVIFREPIIMGNVPRLVPGWTKPIVVGRHAFGDQYRATDLKVPGEGTLTMTFTPKDGSEPIELEVYEFPGAGVALSMYNLDESIRDFARASFRYGLDRGFPVYMSTKNTILKKYDGRFKDVFQEVFDAEFRTEFEAAGLTYEHRLIDDMVASALKWEGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMSPDGRTIEAEAAHGTVTRHYRQHQLGKPTSTNPIASIFAWTRGLAHRGKLDGTPEVTRFAETLERVCVETVEGGQMTKDLAVLISPEQPWLTTEQFLAALDQNLRTKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC88</accession>
    <name>A0A2G1XC88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27650</name>
        <name evidence="4" type="ORF">CYQ11_17990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48842">
        <property type="protein sequence ID" value="PHQ48842"/>
        <property type="gene ID" value="BLA24_27650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14512">
        <property type="protein sequence ID" value="PPT14512"/>
        <property type="gene ID" value="CYQ11_17990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="304" mass="31898" checksum="5B35D6F363FD4DF4" modified="2018-01-31" version="1">MATLRQLEYLVTVVDGGSFTRAAELLHVTQPALSHQIRALERSLGGPLLDRLPRGVRLTPAGRAMLPHARAALADVERARSAARRASGLEEGELQLATVYSVSLGVLPPVLRVWRREHPGVRVRLVEFRHTGELRAAMAAGQADLAVGPPPGEWDGPVRVLGVEEFVVVVPADDPLAGGGADRVELSALADRGWVHYAPGNGLAEVLDGACAAAGFTPRVAVRTEQTAAAAPLAATGLGPALVPANVVPPRFDGRLLRPSPPVTRPLVAYARTRPDALASAFVEVLARHARTERGPGGDGTGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCL3</accession>
    <name>A0A2G1XCL3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribF</name>
        <name evidence="13" type="ORF">BLA24_23000</name>
        <name evidence="14" type="ORF">CYQ11_23075</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48976">
        <property type="protein sequence ID" value="PHQ48976"/>
        <property type="gene ID" value="BLA24_23000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15379">
        <property type="protein sequence ID" value="PPT15379"/>
        <property type="gene ID" value="CYQ11_23075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="187"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ48976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="34715" checksum="7046A9725E516ED2" modified="2018-01-31" version="1">MQRWRGLEDIPQDWGRSVVTIGSYDGVHRGHQLIIGRAVDRARELGVPSVVVTFDPHPSEVVRPGSHPPLLAPHHRRAELVAELGVDAMLILPFTAEFSRLSPADFVVKALVDKLHAKLVVEGPNFRFGHRAAGDVEFLKKLGTTYDYDVEVVDLYVSGEAGGGQPFSSTLTRRLVAEGDVAGAMEILGRPHRVEGVVVRGAQRGRELGFPTANVETLPHTAIPADGVYAGWLTVAGEAMPAAISVGTNVQFDATERTVEAYAIDRVGLELYGLHAAVDFLAYLRGMEKFDSIEALLECMADDVKRSRELVAAHEAAVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCQ1</accession>
    <name>A0A2G1XCQ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ORF">BLA24_23025</name>
        <name evidence="12" type="ORF">CYQ11_23050</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48981">
        <property type="protein sequence ID" value="PHQ48981"/>
        <property type="gene ID" value="BLA24_23025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15374">
        <property type="protein sequence ID" value="PPT15374"/>
        <property type="gene ID" value="CYQ11_23050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="507"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="516"/>
            <end position="523"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="566"/>
            <end position="570"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="620"/>
            <end position="623"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1014" mass="103806" checksum="0FB2F73056D47DE3" modified="2018-01-31" version="1">MAKVRVYELAKEFGVESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDALQGPGGNAGKPAAKPAAPRKAAPAKPGAPTPGAQARPAAPAKPAAAPTPKPASAGPAPSPAPRPGPKPGPAAPKPAPAAPAQPEFQAPPSAPAPSAPKPGVTPGPRPGGARPGPAGQRDGGRPERAPRPGGPGERAPRPGGARPAGPRPGNNPFTSGGSTGMARPQAPRPGGAPRPGGQAGPGGPRPQGGPGGAPRPQGQGGARPTPGGMPRPQAPGGAPRPGAPAGNRPNPGMMPQRPAAGPRPGPGGGGRGPGGGGAGRPGGGAGRPGFAGRPAGPGGGGRPGGGGGFAGRPGGGGPGGGGGFGGGRPGFGGRPGGPGARGGTQGAFGRPGGPARRGRKSKRQRRQEYEAMQAPSVGGVMLPRGGGETIRLSRGASLTDFAEKIGANPASLVAVMMNLGEMVTATQSVSDETLQLLGGEMNYTVQIVSPEEEDRELLESFDIEFGENEGGEEMLVARPPVVTVMGHVDHGKTRLLDAIRKTNVVAGEAGGITQHIGAYQVATEVNDEERKITFIDTPGHEAFTAMRARGAKSTDIAILVVAANDGVMPQTIEALNHAKAADVPIVVAVNKIDVEGADPTKVRGQLTEFGLVAEEYGGDTMFVDISAKQGLNIDSLLEAVILTADASLDLRANAEQDAQGIAIEAHLDRGRGAVATVLVQRGTLRVGDTMVAGDAYGRVRAMLDDKGQNVEEAGPSTPVLVLGLTNVPGAGDNFLVVDEDRTARQIAEKRAARERNAAFAKRTRRVSLEDLDKVLKAGLVQDLNIIIKGDASGSVEALESSLLQLDVGEEVDIRILHRGVGAVTESDINLATGSDAIVIGFNVRAEGRATQMAEREGVDVRYYSVIYQAIEEIEAALKGMLKPEYEEVELGTAEIREIFRSSKLGNIAGVLIRSGEVKRNTKARLIRDGKVIAEELNIVGLRRFKDDVTEIREGFEGGINLGNFNDIKIDDVIATYEMREKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCU5</accession>
    <name>A0A2G1XCU5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">leuC</name>
        <name evidence="17" type="ORF">BLA24_23525</name>
        <name evidence="18" type="ORF">CYQ11_22545</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49063">
        <property type="protein sequence ID" value="PHQ49063"/>
        <property type="gene ID" value="BLA24_23525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15291">
        <property type="protein sequence ID" value="PPT15291"/>
        <property type="gene ID" value="CYQ11_22545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ49063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT15291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="477" mass="50755" checksum="E3DCCDD9141775F2" modified="2018-01-31" version="1">MGRTLAEKVWDDHVVTRAEGEPDLLFIDLHLLHEVTSPQAFDGLRKAGRPVRRLDLTIATEDHNTPTLDIDKPIADPVSRTQLETLRRNCAEFGVRLHPLGDVEQGVVHVVGPQLGLTQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLAPFKTMAVTVEGELPEGVTAKDLILAIIARIGTGGGQGYVLEYRGPAIEKLSMEARMTVCNMSIEAGARAGMIAPDETTFAYLKDRPHAPRGADWDEAVAYWRTLRTDDDAVFDHEVVIDAAELSPFVTWGTNPGQGAPLSSAVPDPASYEDASERQAAEKALEYMGLTAGQALRDIRVDTVFVGSCTNGRIEDLRAAAGVIEGREVAEGVRMLVVPGSVRVALQAVEEGLDKVFTAAGAEWRHAGCSMCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGRLASPADLADATDVRTPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD37</accession>
    <name>A0A2G1XD37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23945</name>
        <name evidence="4" type="ORF">CYQ11_22125</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49130">
        <property type="protein sequence ID" value="PHQ49130"/>
        <property type="gene ID" value="BLA24_23945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15221">
        <property type="protein sequence ID" value="PPT15221"/>
        <property type="gene ID" value="CYQ11_22125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="27084" checksum="27C9F3FEF61060C6" modified="2018-01-31" version="1">MTVHLEVAEGVGTVRLDRPPMNALDIATQDRLRELADEITHRADIRSVVIWGGEKVFAAGADIKEMQHMDHAAMVARSRGLQDSFTAVARIPKPVVAAVTGYALGGGCELALCADFRIAADTAKLGQPEILLGLIPGAGGTQRLARLVGPSKAKDLIFTGRQVKADEALAIGLVDRVVPAAEVYERAHAWAARLAAGPAIALRAAKEAVDTGLETDIDTGLAIERNWFAGLFATQDREIGMRSFVEDGPGKAKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD90</accession>
    <name>A0A2G1XD90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_24335</name>
        <name evidence="7" type="ORF">CYQ11_21735</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49198">
        <property type="protein sequence ID" value="PHQ49198"/>
        <property type="gene ID" value="BLA24_24335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15152">
        <property type="protein sequence ID" value="PPT15152"/>
        <property type="gene ID" value="CYQ11_21735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="186"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="29807" checksum="95FD281BD4228367" modified="2018-01-31" version="1">MAKKLAVIGAGLMGSGIAQVSAQAGWDVVLRDVTDEALKRGTDGIKASYDKFVAKGKLEAGAAEAALGRITATTDLDAVADADIVVEAVFEDVDVKREIFRTLDGLVGDETVLASNTSAIPITKIAAATKRPERVVGAHFFSPVPMMQLCELVRGHKTSDETLARAREFAEGVGKTCIVVNRDVAGFVTTRLISALVVEAAKLYESGVASAEDIDVACKLGFGHAMGPLATADLTGVDILLHATGNIYTECQDEKFAPPELMRRMVDAGDLGRKSGQGFYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD91</accession>
    <name>A0A2G1XD91_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_24360</name>
        <name evidence="11" type="ORF">CYQ11_21710</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49203">
        <property type="protein sequence ID" value="PHQ49203"/>
        <property type="gene ID" value="BLA24_24360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15147">
        <property type="protein sequence ID" value="PPT15147"/>
        <property type="gene ID" value="CYQ11_21710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="26344" checksum="5BAB2EEAB9F93C74" modified="2018-01-31" version="1">MRTLLSDTALVFGRYARQTLRSKAAMTFGALMPALYLVLYGPLLTGLPLGDGRGGGSWRVLVPGLLLQLALFGASFAGLGIIIEKQHGVVERMRVTPVSRPALLLGRVLRDAALLTVQSVLLVVVAFAMGLRAPLPGVLIGLAFTASLALSLASLSCTLAVKSPTPQAFAPVVNTVTMPAMLLSGLLLPMSLAPGWLDALSHVMPLRYLVDAVRAAFAGDYTSDALLSGTVAALALTAASVTVGTRHFRRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDD6</accession>
    <name>A0A2G1XDD6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24575</name>
        <name evidence="2" type="ORF">CYQ11_21495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49240">
        <property type="protein sequence ID" value="PHQ49240"/>
        <property type="gene ID" value="BLA24_24575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15108">
        <property type="protein sequence ID" value="PPT15108"/>
        <property type="gene ID" value="CYQ11_21495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="27010" checksum="F3CFE16DC391C08C" modified="2018-01-31" version="1">MRIELATQPADPHRPNEDFASVALPASGRGGALVLLDGVTPPPDGATGCEHGVAWFTARLGGALLELLAARRELTPAACLSAAISRTADAHRGTCDLAHRRTPQATVVLARWDEERVEHLVLSDSVLLAEGTDGTVTPVLDDRIARLAALGPVTDAQRNAEGGFFTAAADPAVAVRAVTGSWARAEVRALAALSDGAARWVEVFGAGDWAECFALLAKEGPRALIDEVRAAERADPDGTVFRRGKRHDDAVALHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDK3</accession>
    <name>A0A2G1XDK3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24980</name>
        <name evidence="5" type="ORF">CYQ11_21090</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49312">
        <property type="protein sequence ID" value="PHQ49312"/>
        <property type="gene ID" value="BLA24_24980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15038">
        <property type="protein sequence ID" value="PPT15038"/>
        <property type="gene ID" value="CYQ11_21090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="22531" checksum="9D1911C603CE8F86" modified="2018-01-31" version="1">MPAARELLLDAAYTALGARPWNGVRMVDVAAAAGVSRQTLYNEFGSKDGLARALVRREADAFFAGVERALAETAGVGGADAGDCYAAAARWILRTARANPFVRAALTGCRGDRLPPAAVPPVPAPRRPAGPLPPRGAPSPGALAERLRDSAARAIGGAAECDGATRRACEAAVRLTLSYVIAPAGTDEEAAHEVAHLVRVLLNAPQRAGVSAPTPTAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDK5</accession>
    <name>A0A2G1XDK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49317">
        <property type="protein sequence ID" value="PHQ49317"/>
        <property type="gene ID" value="BLA24_25010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="657" mass="69716" checksum="90D3FF72CEAE36AB" modified="2018-01-31" version="1">MGDKARLLETRRLVGAPADGSDQDGDRNPSSYGPGGQGEGSSPDAGCATEAADLELETARRRAAESGDPASLSMLGALLLRRGDLDGAERHLRAATAEGDRSAANNLGVLLHQRGYADEAAAWWRVAAVAGSAPAAHALGRYHRERGDEPAAEYWLRQSAESGHALGAYALADLLEHRSDVDAERWFRSAAERGHREAAYRLARILDGRSPGAQARSGGLDDGLGGSLVPSTNSRLVAVGGGDTSVRELRAAAAAGGRRPDGPAGEAEQWYRQAAARGHRRAALHLGTLLEARGETQEAARWYLTSAKDGEPRAACALGFLLRDAGDTDSAAVWWRRAAQEGDGNAANALGALHADRGEPQQAERWYRTALDAGDVNGAYNLGLLCAEQGRTAQAEQWYRRAAYAGHKEAANALAVLLLQGGDSAGAEPWFSKAAEAGSVDAAFNLGILYAGRDEDETAFQWYERAAAAGHTDAALQVAMALLREGGPEAGEEAERHLRTAVKGGNAEAAFRLGALLDRDDDGHGRFECEEWYERAARQGHRRAQVRLGMLVAERGDVVAAAHWYRQAAEAGSRNGAFNLGLLLAREGSEQEAALWWARAAEAGHGRAALRLALLAARRGDLAEGRLWCAQAVELGPAEVAERAARLRDALSQELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDP1</accession>
    <name>A0A2G1XDP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_25220</name>
        <name evidence="5" type="ORF">CYQ11_20850</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49354">
        <property type="protein sequence ID" value="PHQ49354"/>
        <property type="gene ID" value="BLA24_25220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14998">
        <property type="protein sequence ID" value="PPT14998"/>
        <property type="gene ID" value="CYQ11_20850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304592" evidence="2">
        <location>
            <begin position="27"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="95"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="573" mass="61208" checksum="025D1BC639AA3C90" modified="2018-01-31" version="1">MRHMSLISRAVAASAVSVVLIGGAVACGPEKSGGDAGSGAAGAPKKGGTLTVLNRAPQKQFDPARLYTSGGGNIPSLVYRTLTTRNRESGAEGTKVVPDLATDTGTPSDDAKTWTFKLKDGLKYEDGSPITAADVKYGVERSFAAELSGGAPYLRDWLVGGDTYQGPYKEKKGLDSIETPDEKTIVFKLRKSEGDFPFYATSTQFAPVPKSKDTGVKYAEHPVSSGPYKVVKNVGDGEQMVLERNPNWSEETDKERHAYPDRIEVRSGLDPAVINQRLSSGQGADAAAVTTDTNLGPAELARVGGDGKLADRVGTGHFGQTSYLAFNPAVKPFDNPKVRQAISYAINRTSVVNAAGGSSLAEPATTFLPDQKPLGYTPYDHFPAGAKGDPGKARELLKEAGYDNGLEITLTHSTAQNFETSPEIATAVQAALKEAGITVKLEGLEDNDYDEKIHSFAKQPGLFIAHWGADWPSGGPFLAPVFDGRQIVKDGANFNTARLDDPKVNDEIDEINKITDHDAAAARWGALDKRIGEQALTVPLFHPVYKRLYGKDVKNVVISDWTGVLDVSQVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDP8</accession>
    <name>A0A2G1XDP8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_25285</name>
        <name evidence="9" type="ORF">CYQ11_20790</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49364">
        <property type="protein sequence ID" value="PHQ49364"/>
        <property type="gene ID" value="BLA24_25285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14988">
        <property type="protein sequence ID" value="PPT14988"/>
        <property type="gene ID" value="CYQ11_20790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="21217" checksum="1B934B9916BB42D2" modified="2018-01-31" version="1">MFDIAVFGSLFLTLFVIMDPPGVTPIFLALTAGRPAKVQKRMAWQAAAVAFGVITVFGICGQQILDYLHITTPALMIAGGLLLLLIALDLLTGKSEEPTQTKDVNVALVPLGMPLLAGPGAIVSVILAVQHADSFGAQVSVWCAIAAMHVVLWVVMRNSLLIIRVIKDGGVVLVTRLAGMMLSALAVQQIINGITQVIDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDQ9</accession>
    <name>A0A2G1XDQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25315</name>
        <name evidence="3" type="ORF">CYQ11_20760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49370">
        <property type="protein sequence ID" value="PHQ49370"/>
        <property type="gene ID" value="BLA24_25315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14982">
        <property type="protein sequence ID" value="PPT14982"/>
        <property type="gene ID" value="CYQ11_20760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="17670" checksum="B0FB660183E6762A" modified="2018-01-31" version="1">MTMTQALIEEATKKSGLIWVQGPAGPSRALWHVWHEGAAYVVGGPGEQPLDGLGLTGGATATVTVRSKDKGGRIVSWTAAVTELAPREEAWTAVVAELKGKRLNAPDAEGLEERWAGSCRVLRLAPTGASSNLPSDSLAAVPLPTPATTRHPMPAALPKLLRRGRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE64</accession>
    <name>A0A2G1XE64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26060</name>
        <name evidence="3" type="ORF">CYQ11_20005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49502">
        <property type="protein sequence ID" value="PHQ49502"/>
        <property type="gene ID" value="BLA24_26060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14847">
        <property type="protein sequence ID" value="PPT14847"/>
        <property type="gene ID" value="CYQ11_20005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="82" mass="9318" checksum="6BA479E6D358328B" modified="2018-01-31" version="1">MHKRKAGELQAKPTPPVGTVEQRNRPPGDVRIGDFLYLDGAFQRVRDMRAAGTSAHRVLHFTGRAPVIMREPRTIYRPLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE86</accession>
    <name>A0A2G1XE86_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26330</name>
        <name evidence="4" type="ORF">CYQ11_19310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49547">
        <property type="protein sequence ID" value="PHQ49547"/>
        <property type="gene ID" value="BLA24_26330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14732">
        <property type="protein sequence ID" value="PPT14732"/>
        <property type="gene ID" value="CYQ11_19310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="17935" checksum="E6C250D8FDD7E3C0" modified="2018-01-31" version="1">MALRGTNTRSTRPGGNSPAAGGGPARPCRWVRARTRVRVRAGTGGPASDRGSASVEFLGFLPLLLLLALGAVYLGLTAFAAEQAGTGARAAARTATQDEPQGAPEGAGRAAMTAWVADRADVVAPRCASGGEITVTVTVDVPALIPGTDFSVSRRATMPCPDDPAPVPAVPAPAPAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL2</accession>
    <name>A0A2G1XEL2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27040</name>
        <name evidence="5" type="ORF">CYQ11_18590</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49668">
        <property type="protein sequence ID" value="PHQ49668"/>
        <property type="gene ID" value="BLA24_27040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14609">
        <property type="protein sequence ID" value="PPT14609"/>
        <property type="gene ID" value="CYQ11_18590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304806" description="Phytase-like domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="66"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="346" mass="36731" checksum="11F521236F3749C4" modified="2018-01-31" version="1">MRARTTFVSLAAVLVTAVAGAVPATAAAPAPGHAANHDSDRPCTPDVSLAGFSDALDKTYFQGSYVGNLSALARDSGGRTAALSDRSLLFTLDAQRKPERVLRLADENGKDLDSEGLVIDRDGGYLVTSETEPSVRRYDRDGKLLGALPVPDELRVAPAGKAQLNQTFEGLTLLPGGNTLVASMEGALSGDGTDDQGRPLVRFQTWQRSGGHGEFGLGRQYAYPVDKTLGVSEVTAADESHLLVLERGFSATTGLTVRLYLADLSAARTDAGRPVPKRLLADLGGCTSPDAHHPTPQPNPLLDNVEGMTVTGREPDGRLKLLLVSDDNQSTRQVTRLYELTVRVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEN8</accession>
    <name>A0A2G1XEN8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_27075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49675">
        <property type="protein sequence ID" value="PHQ49675"/>
        <property type="gene ID" value="BLA24_27075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="7">
        <location>
            <begin position="34"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="304" mass="34395" checksum="17940ED2F4E3A49D" modified="2018-01-31" version="1">MSAVSSPYVLSHVDVLESEAVHVFREVAGEFERPVMLFSGGKDSIVMLHLALKAFAPAAVPFALLHVDTGHNFPEVLAYRDRVVAEHGLRLHVASVQEFIDDGRLRERGDGTRNPLQTVPLLEAIGRHRFDAVFGGGRRDEEKARAKERVFSLRDEFGGWDPRRQRPELWQLYNGRHAPGEHVRVFPLSNFTELDVWQYIAREKIELPSIYFAHEREVFAREGMWLAPGGWGGPREGERVERRLVRYRTVGDMSCTGAVDSDAVTIEAVIAEITASRLTERGATRADDKLSEAAMEDRKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XER5</accession>
    <name>A0A2G1XER5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_24080</name>
        <name evidence="8" type="ORF">CYQ11_21990</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49712">
        <property type="protein sequence ID" value="PHQ49712"/>
        <property type="gene ID" value="BLA24_24080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16714">
        <property type="protein sequence ID" value="PPT16714"/>
        <property type="gene ID" value="CYQ11_21990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="453" mass="46022" checksum="7DECAB291A4CAC3E" modified="2018-01-31" version="1">MIVLDTTIVTIALPAAQQDLGVSDASRQWVITAYTLAFGGLLLLGGRIADRLGRRRTLIAGILGFAVASGLGGMADSGWMLVAARAGQGVFAALLAPSTLALLMAVFPGPAERARAIGIYSGVLTAGGGIGLVGGGLITSYLDWRWCMYVNIPIALLAALGAVATLPDLPGRTDARIDVLGALTGCGGIAALVYGFSEAGEHGWHTLRVVLCLALAVALLLTFGIAQARLRAPLLPLRILTDRNRSAALATVALATLGLFGVFLFLTYQLQSVMGYSAVKTGLAMLPLVAMNVTAATQMSGRLLPKLPPRLLIVPGLLCAAGSLALLTQLTPHSSYTAVILPAELLLGLGIGTLFGPAVATATSGVAPHDAGIASATVNTAQQTGASIGTALLNTIAASATSTYLADHHGADVLRDATVHGYATAATWALGIMLGTAVLAALSITADPRKSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEU0</accession>
    <name>A0A2G1XEU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF192 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26255</name>
        <name evidence="2" type="ORF">CYQ11_19385</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49748">
        <property type="protein sequence ID" value="PHQ49748"/>
        <property type="gene ID" value="BLA24_26255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16672">
        <property type="protein sequence ID" value="PPT16672"/>
        <property type="gene ID" value="CYQ11_19385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="138" mass="14960" checksum="622024450750A126" modified="2018-01-31" version="1">MPRHQRFRDGNTQLRVPGGTVVPLEVAASFRSRTRGLLGRDGLDGALLLTPAGSVHTWRMRFTIDVAYLTRDLTVLSVRTMPPGRLGVPRLRARHVLEAEAGAMERWGLRRGVRLEVLPPRPGAPGAGLRPGDVSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF18</accession>
    <name>A0A2G1XF18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19445</name>
        <name evidence="4" type="ORF">CYQ11_11355</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49822">
        <property type="protein sequence ID" value="PHQ49822"/>
        <property type="gene ID" value="BLA24_19445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13403">
        <property type="protein sequence ID" value="PPT13403"/>
        <property type="gene ID" value="CYQ11_11355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="62" mass="6905" checksum="B64059AFA624F6E6" modified="2018-01-31" version="1">MNQRNIPPRWRKSSYSNSGSGGCVEVAPLEGEVRVRDSKFPTQPAITFSRFSWATFLAELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF47</accession>
    <name>A0A2G1XF47_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19460</name>
        <name evidence="3" type="ORF">CYQ11_11340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49825">
        <property type="protein sequence ID" value="PHQ49825"/>
        <property type="gene ID" value="BLA24_19460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13400">
        <property type="protein sequence ID" value="PPT13400"/>
        <property type="gene ID" value="CYQ11_11340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="206" mass="22284" checksum="C2CB43F39D0D22DB" modified="2018-01-31" version="1">MASAAASYDLRFDSGRLCLDLVATVGRRLSEEPVERLDVPDRLRAWLLGAGVVPPGTPLDAVDAAWLARFHAVRDLLHRVVHAEVDGRAADSDLERVNALAATAPPALRAVRAADGSLVRAVGEAPDCGALLGRIARDAVELLTDATAREQLRRCEGEACSLLYLDTSRGRRRRWCSSEVCGNRERVARHRRRAVMNGKAVTAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF53</accession>
    <name>A0A2G1XF53_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19650</name>
        <name evidence="3" type="ORF">CYQ11_11145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49857">
        <property type="protein sequence ID" value="PHQ49857"/>
        <property type="gene ID" value="BLA24_19650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13367">
        <property type="protein sequence ID" value="PPT13367"/>
        <property type="gene ID" value="CYQ11_11145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="20894" checksum="5AB6EA04BD70A623" modified="2018-01-31" version="1">MNRALIIVDVQNDFCEGGSLAVAGGSDVAAAITDLVAAAPAGYAHVVASRDMHVEPGEHFSDRPDFERSWPRHCVAGTEGSGFHPNFSPAITSGAVQAVFDKGAYEAGYSAFQGTDENGTALAEWLRERDVREVDVVGIAIDYCVRATALDARREGFTTRVLLDLTAGVARETTDRTLEELREAGVELSGKPVVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF71</accession>
    <name>A0A2G1XF71_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Choice-of-anchor A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01450</name>
        <name evidence="3" type="ORF">BLA24_19820</name>
        <name evidence="5" type="ORF">CYQ11_10970</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000023">
        <property type="protein sequence ID" value="PHQ53390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49886">
        <property type="protein sequence ID" value="PHQ49886"/>
        <property type="gene ID" value="BLA24_19820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53390">
        <property type="protein sequence ID" value="PHQ53390"/>
        <property type="gene ID" value="BLA24_01450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13338">
        <property type="protein sequence ID" value="PPT13338"/>
        <property type="gene ID" value="CYQ11_10970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026588">
        <property type="entry name" value="Choice_anch_A"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04215">
        <property type="entry name" value="choice_anch_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="445" mass="45314" checksum="C6D13AED58922D46" modified="2018-01-31" version="1">MSEEERARWRPTRPAATVTAALISVGGVLLACAFTAADRTEPVPAGPGPCVPGTCPETYPEPHSGPFAGRDNGVNVFVGGDFTVRQAAGEAEGRVVTLGAFQMAKGGGVPEYYRVGAAGTGSRVPPDNGLPYLRVGGDLRIAPHQRLLAEEGTASGTVAYAGALTGTVAPKAAHDEAAVAEYRQLREELTSASTCYAYDKGVPRKATGTAVNQGNRTLFTGDGKSALQVFNVPFDLTGRSDAPQDLVFEAVPRDATVLVNLTNARGSAKKVVNSSATALVGVRRERLLWNIPDAKEIRLTGSGQLDGAVLAGRRAGLTHLTVPVVNGRFFTAGSLTHESGAGAAGQAIHAYPFEGTLPECGTGPTADPDTAEPAPSPVPSAPATLPADAAAGPPDVAGAAAVAGDARGLSHGGPPMETSMAVGATLIALGAGLALTVLYRTRPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF78</accession>
    <name>A0A2G1XF78_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19840</name>
        <name evidence="3" type="ORF">CYQ11_10950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49890">
        <property type="protein sequence ID" value="PHQ49890"/>
        <property type="gene ID" value="BLA24_19840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13334">
        <property type="protein sequence ID" value="PPT13334"/>
        <property type="gene ID" value="CYQ11_10950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="290" mass="32344" checksum="F55EDE078FC744DA" modified="2018-01-31" version="1">MGQPARRTARRRRLGGALKDAREAAQVSAIEAAQAIHGDNTKISRIETGRHRVTRLELETLLNLYQVKDEQTRDWLIALASEGRKRSWWRQHSDALPPGLKELLTLESDAAKICAFQSQVIPGLLQTREYATAVMAGAEQKQMSTEKLDFFVDLRMNRQQIFQQDNAPSYLCIMPEGVVRQQLGGPKVMAAQLRHLIALNRPPMMTIQVIPFSQGAFTATGGSFVLYSYPDPLDLDVVQVEYLDGALYLEEDETVEKYRSALDGLRAAALSSQQSVDLISSIARDLEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFA5</accession>
    <name>A0A2G1XFA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20075</name>
        <name evidence="4" type="ORF">CYQ11_10715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49926">
        <property type="protein sequence ID" value="PHQ49926"/>
        <property type="gene ID" value="BLA24_20075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13298">
        <property type="protein sequence ID" value="PPT13298"/>
        <property type="gene ID" value="CYQ11_10715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304881" evidence="2">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="90" mass="9190" checksum="68019BC9AF409B40" modified="2018-01-31" version="1">MSDVVRWAAFSCALVPVVLLMCGQSLGGAAGTAAGLVALTCACRALLRQSERTAARALAEQSASHRGRHGRTGGGSHRGPRRPGSGHPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFP6</accession>
    <name>A0A2G1XFP6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_20660</name>
        <name evidence="10" type="ORF">CYQ11_10120</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50025">
        <property type="protein sequence ID" value="PHQ50025"/>
        <property type="gene ID" value="BLA24_20660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13197">
        <property type="protein sequence ID" value="PPT13197"/>
        <property type="gene ID" value="CYQ11_10120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="98"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="23339" checksum="583C802E183C07BB" modified="2018-01-31" version="1">MAIYTLPELPYDYSALAPVISPEIIELHHDKHHAAYVKGANDTLEQLAEARDKDQWGAVNGLEKNLAFHLSGHILHSIYWQNMSGEGGGEPLEQDGVGELANAIAESFGSFAKFKAQLSKASATTQGSGWGVLAYEPVSGRLIVEQVYDHQGNVGQGSVPVLVFDAWEHAFYLQYKNQKVDFIEAMWKVVNWQDVAARYAAAKAKGNSILLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFR1</accession>
    <name>A0A2G1XFR1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">BLA24_20970</name>
        <name evidence="10" type="ORF">CYQ11_09810</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50073">
        <property type="protein sequence ID" value="PHQ50073"/>
        <property type="gene ID" value="BLA24_20970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13146">
        <property type="protein sequence ID" value="PPT13146"/>
        <property type="gene ID" value="CYQ11_09810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="18"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="434" mass="45699" checksum="A50B7D021964EEA3" modified="2018-01-31" version="1">MSSVFPSPLADPMPQSPVLRAAYRARAAAADLAPLPRSAKDEALLAIADALEVRTREILAANAEDVEKALAAGTAESVVDRLTLTPERVRAIAADVRDVAALPDPVGEVVRGSTLPNGLDLRQVRVPLGVVGIIYEARPNVTVDAAALCLKSGNAVLLRGSSSAYASNTALVRVIRDAVGGAGLPADAVQLVPGESRESVRELMRARGMVDVLIPRGGASLIRTVVQESTVPVIETGTGNCHVYVDAEADLDMAVEILVNSKTSRVSVCNAAETLLVHQDIAERFLPLALRALAESGVTVHGDERVVELAETARTGATVVPATAEDWETEYLSYDIAAAVVEDLDAAVRHIRLWTSGHTEAIVTTSQAAARRFTQLVDSTTVSVNASTRFTDGGQFGFGAEIGISTQKLHARGPMGLPELTSTKYILTGDGHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFW4</accession>
    <name>A0A2G1XFW4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3097 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21105</name>
        <name evidence="2" type="ORF">CYQ11_09680</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50095">
        <property type="protein sequence ID" value="PHQ50095"/>
        <property type="gene ID" value="BLA24_21105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13125">
        <property type="protein sequence ID" value="PPT13125"/>
        <property type="gene ID" value="CYQ11_09680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="275" mass="29728" checksum="05B88B28AD092433" modified="2018-01-31" version="1">MRSREYGPDLTPPWKRSAPVPEVPAEAGLVVEETTTGFCGAVVRCEKTAQGPTVTLEDRFGKCRVFPMEPRGFLLEGRVVTLVRPAASSAPAGPVRTASGSIAVPGARARVARAGRIYVEGRHDAELVERVWGDDLRIEGVVVEYLEGVDDLPALVRFFGPGPDARLGVLVDHLVPGSKESRIAAEVTGEHVLVVGHPYVDVWEAVKPSSVGIPEWPRVPRGLDWKTGVCEALGWPANTGAAWQRILSRVRSYKDLEPALLGRVEELIDFVTAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG49</accession>
    <name>A0A2G1XG49_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21870</name>
        <name evidence="2" type="ORF">CYQ11_08915</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50220">
        <property type="protein sequence ID" value="PHQ50220"/>
        <property type="gene ID" value="BLA24_21870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12996">
        <property type="protein sequence ID" value="PPT12996"/>
        <property type="gene ID" value="CYQ11_08915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="121" mass="13181" checksum="E109CF41C3EEAF3B" modified="2018-01-31" version="1">MTSTTREQTPVTVEGEGLEVRTQDIGGGMSVMFMRAAAGTDLGPALKGLPDDLCQCPHWGFLAKGRVRIRTKDGEEMYESGQAFYWGPGHAPSMVEDTEFVDFSPTEKVNEVVSHVKAQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG97</accession>
    <name>A0A2G1XG97_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transglycosylas domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_22135</name>
        <name evidence="6" type="ORF">CYQ11_08650</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50256">
        <property type="protein sequence ID" value="PHQ50256"/>
        <property type="gene ID" value="BLA24_22135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12958">
        <property type="protein sequence ID" value="PPT12958"/>
        <property type="gene ID" value="CYQ11_08650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304626" description="Transglycosylas domain-containing protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="4">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="402" mass="41787" checksum="9EEBB27DF3BE7AF7" modified="2018-01-31" version="1">MSSSSRIARRLLPLVVAPVAALSLFGSGTASAASVATWDKVAQCESSGNWHINTGNGYYGGLQFSQDTWESYGGKKYAARADLASKEEQIRIAEKVLKGQGPGAWPSCGARAGLGNDHADPYPDKPTPTDPGMTELTAGDLNADGKKDVVAVKVETGELFLYPNTGKSGLDMLGDRVLIGTGGWNGMKDLTVGDFNGDGKDDLVAAKKETGELFLYPGTGKKGLDALGDRVLIGTGGWNGMKHLAAADFNGDGKADLIAAKTETGELFLYPNTGKKGLDTLGSRTLVGTGGWNGMNKVVAARDFNGDGGPDLIATKTATGQLFVYAGTGKSGTEMFDSPREIGTGGWNGISDYAAADFNGDGITDLVAVDSDARETGKLYLYKGNSQKGGLDSRVEIGTGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGK7</accession>
    <name>A0A2G1XGK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50370">
        <property type="protein sequence ID" value="PHQ50370"/>
        <property type="gene ID" value="BLA24_20025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="133" mass="13609" checksum="D822F2623489DB7A" modified="2018-01-31" version="1">MHQPRQDHSPSAGVATEAGPCDLVTVPARQGLEAVDILRLRDGVGPVLHDGDCDTLGFLVPAGTAAAWDVPGSACTQTHGRGLRLGPVAEPPVNGTGWLVAPDAAYASATDPAVLRAALGEAARTIEAVDRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGS7</accession>
    <name>A0A2G1XGS7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19140</name>
        <name evidence="1" type="ORF">BLA24_22765</name>
        <name evidence="3" type="ORF">CYQ11_14155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000152">
        <property type="protein sequence ID" value="PHQ49777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000150">
        <property type="protein sequence ID" value="PHQ50436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49777">
        <property type="protein sequence ID" value="PHQ49777"/>
        <property type="gene ID" value="BLA24_22765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50436">
        <property type="protein sequence ID" value="PHQ50436"/>
        <property type="gene ID" value="BLA24_19140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13880">
        <property type="protein sequence ID" value="PPT13880"/>
        <property type="gene ID" value="CYQ11_14155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="9033" checksum="ECACFED2AB631B8A" modified="2018-01-31" version="1">MDGVSTYLALTFGTLLSSQGTDASFVLTLSGFPPGASLRCSQPYQIRFPFRFRFAFRFRPPVGAGFFAPSGVITTLADFPRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT2</accession>
    <name>A0A2G1XGT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21170</name>
        <name evidence="3" type="ORF">CYQ11_09615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50401">
        <property type="protein sequence ID" value="PHQ50401"/>
        <property type="gene ID" value="BLA24_21170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16452">
        <property type="protein sequence ID" value="PPT16452"/>
        <property type="gene ID" value="CYQ11_09615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="15776" checksum="7876EBB913E153B1" modified="2018-01-31" version="1">MTAAEVNVLTVGAEDAGLTDRLENELDAFNDAATGKAERGDFSVRVDDADGHLVGGLTAWTWGGLCGIELLWVREDSRAGGWGSKLLLAAEAEAVRRGCDRVMVSSYTFQAPGFYERHGYGEVGRVPGVPGGHADVYLFKSLAGGAVQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX1</accession>
    <name>A0A2G1XGX1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mtnA</name>
        <name evidence="3" type="ORF">BLA24_19120</name>
        <name evidence="4" type="ORF">CYQ11_11610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000149">
        <property type="protein sequence ID" value="PHQ50441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50441">
        <property type="protein sequence ID" value="PHQ50441"/>
        <property type="gene ID" value="BLA24_19120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13447">
        <property type="protein sequence ID" value="PPT13447"/>
        <property type="gene ID" value="CYQ11_11610"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="383" mass="39323" checksum="65C841CA7B4A82A2" modified="2018-01-31" version="1">MADQHAAPVTASAPLSRTEAVPVVPALRWEDLPEGPVIVLLDQRRLPAAEVELVCTDVPALVEAIRTLAVRGAPLLGVAGAYGLALAAVRGFDVDEAAELLAHARPTAVNLAYGVRRALSAHHAALKDGAGAQEAAAATLAAARALHREDAEASERMAEHGLALLQELVPGGGFRVLTHCNTGALVSGGEGTALAVAGAAHRAGELRRLWVDETRPLLQGARLTAYEAARAGMPYTLLTDSAAGSLFSAGEVDAVLVGADRIAADGSVANKVGSYPLAVLARYHHVPFVVVAPTTTVDPRTPDGASIEVEQRSGLEVTEFPGSGASAPLAPLGTQAYNPAFDITPPELVTAIVTENGVVSPVTEEGLAELCARSRSGNGMMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH48</accession>
    <name>A0A2G1XH48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Copper-translocating P-type ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Cu(2+)-exporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_17215</name>
        <name evidence="12" type="ORF">CYQ11_16060</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50556">
        <property type="protein sequence ID" value="PHQ50556"/>
        <property type="gene ID" value="BLA24_17215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14190">
        <property type="protein sequence ID" value="PPT14190"/>
        <property type="gene ID" value="CYQ11_16060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="759" mass="78181" checksum="B66BA2AB69B4DB99" modified="2018-01-31" version="1">MTSMAPEKPATPAPSGAEVELSIGGMTCASCAARIEKKLNRMDGVTATVNFATEKAKVAYAPGVEVADLIATVEKTGYTAQEPPKPTAPAAAETPQEQEAGHSGGALDALRQRLLVSLVLSVPVVLMAMVPALQFDNWQWLSLTLAAPVVVWGALPFHTAAWTNARHGAATMDTLVSIGTLAALGWSLWALFFGHAGMPGMRHGFDFAVSRADGSSSIYLEAAAGVTAFILAGRYLEAKSKRKAGAALRALLELGAKDVAVLRDGREVRVPVGELAVGDRFVVRPGEKIATDGTVVEGGSAVDASMLTGESVPVDVTVGDAVTGATVNVSGRLVVEATGVGADTQLARMARLVEDAQNGKAAVQRLADRISGVFVPVVLLIAVGTLLTWLLVTGDTAAAFTAAVAVLIIACPCALGLATPTALMVGTGRGAQLGILIKGPEVLESTRRVDTVVLDKTGTVTTGKMALHEVVTTPGVTEQELLRLAGALEHASEHPLARAIADGAAERTGTLPVPESFENIAGLGVQGVVDGHVVLVGREKLLAEWVIELPAELAAAKAAAEAEGRTAVAVAWDGRARGVLTVADKVKDTSAQAVAELRRLGLTPVLLTGDNKAVAEAVAREVGIDEVIAEVLPQDKVDVVKRLQSEGRTVAMVGDGVNDAAALATADLGLAMGTGTDAAIEAGDLTLVRGDLMVAADAIRLSRRTLATIKGNLFWAFGYNIAALPLAAAGMLNPMIAGAAMAFSSVFVVTNSLRLRRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHF5</accession>
    <name>A0A2G1XHF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">B/F/G family RNA polymerase sigma-70 factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17300</name>
        <name evidence="8" type="ORF">CYQ11_15975</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50569">
        <property type="protein sequence ID" value="PHQ50569"/>
        <property type="gene ID" value="BLA24_17300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14177">
        <property type="protein sequence ID" value="PPT14177"/>
        <property type="gene ID" value="CYQ11_15975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="30826" checksum="2EC1DE31FF9B8647" modified="2018-01-31" version="1">MSVDLGSAKVLANDAPHTVLDDCEAIDTRTLSRSLFLRLATLERDSAERTYVRDTLIELNLPLVRYAAARFRSRNEPMEDIVQVGTIGLIKAIDRFDCERGVEFPTFAMPTVVGEIKRFFRDTSWSVRVPRRLQELRLALTKASDELAQKLDRSPTVPELALCLGVSEEDVVDGLAVGNAYTASSLDSPSPEDDGGEGSLADRLGYEDTALEGVEYRESLKPLLAKLPPRERQIIMLRFFANMTQSQIGEEVGISQMHVSRLLTRTLAQLREGLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHG2</accession>
    <name>A0A2G1XHG2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ORF">BLA24_17910</name>
        <name evidence="7" type="ORF">CYQ11_15365</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50670">
        <property type="protein sequence ID" value="PHQ50670"/>
        <property type="gene ID" value="BLA24_17910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14075">
        <property type="protein sequence ID" value="PPT14075"/>
        <property type="gene ID" value="CYQ11_15365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="34436" checksum="469A78DEAB10F754" modified="2018-01-31" version="1">MSDVRNVIIIGSGPAGYTAALYTARASLKPLVFEGAVTAGGALMNTTDVENFPGFREGIMGPDLMDNMRAQAERFGAELIPDDVTAVDLSDEIKTVTDSAGTVHRAKAVIVTTGSQHRKLGLPREDELSGRGVSWCATCDGFFFKDQDIAVIGGGDTAMEEATFLSRFAKSVTVVHRRDALRASKAMQERAFADPKISFVWNSEVAAIHGENKLSSLTLRDVNTGDVSELPVTGLFIAIGHDPRTELFKGQLELDDEGYLKVTAPSTRTNLRGVFAAGDVVDHTYRQAITAAGTGCSAALDAERYLASLSDSESVREPEQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHI5</accession>
    <name>A0A2G1XHI5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2252 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18150</name>
        <name evidence="2" type="ORF">CYQ11_15125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50708">
        <property type="protein sequence ID" value="PHQ50708"/>
        <property type="gene ID" value="BLA24_18150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14038">
        <property type="protein sequence ID" value="PPT14038"/>
        <property type="gene ID" value="CYQ11_15125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="465" mass="49274" checksum="7D73A92863514768" modified="2018-01-31" version="1">MARLPYVPGFARPGAGESGHKAVKAAGKALRERVPRSAHAEWRADAGRPGAVETVEATNAGRLPELTPLRIGRMVASPFAFLRGTAGLMGHDLAGTAVTGVGAQLCGDAHAANFGLFGDARGELIIDLNDFDETVHGPWEWDVKRLAASLVLAGREAGAGEAECRAAARDAAGAYRHTMRLLARMPVVEAWNAIADEKLVSHADAHQLLGTLERVAEKARRNTSARFAAKATERDGEGGRRFADAPPVLRRVPGAEAAAVASALGPYLGTLPEDLLPLLGRYEVQDVAFRVVGTGSVGLRSYVVLLLDHRGEPLVLQVKEARPSVLLPFVEKAGFEAPGAGHEGRRVVLGQKSMQVVSDVLLGWTTVEGRPYQVRQFRNRKGSVDPAALAPGELDDYGRMTGALLARAHAHSADPLLIAGYCGKGEELDEAVATFAVTYADRMEADHTELLAAVRSGRLAAETGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHJ2</accession>
    <name>A0A2G1XHJ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18065</name>
        <name evidence="3" type="ORF">CYQ11_15210</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50695">
        <property type="protein sequence ID" value="PHQ50695"/>
        <property type="gene ID" value="BLA24_18065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14050">
        <property type="protein sequence ID" value="PPT14050"/>
        <property type="gene ID" value="CYQ11_15210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="70" mass="7717" checksum="FF7B3551A4EF2A35" modified="2018-01-31" version="1">MYVWIWRHLPGNAWVRALISLLLVLGIVYVLFQYVFPWAEPLLPFNDVTVDNGMSAGDAIAVGDGTAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHM7</accession>
    <name>A0A2G1XHM7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18385</name>
        <name evidence="4" type="ORF">CYQ11_14895</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50748">
        <property type="protein sequence ID" value="PHQ50748"/>
        <property type="gene ID" value="BLA24_18385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13994">
        <property type="protein sequence ID" value="PPT13994"/>
        <property type="gene ID" value="CYQ11_14895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="2">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="16616" checksum="29BFF832D38BAF57" modified="2018-01-31" version="1">MYGYDQNAAQQGYAPPQQPGGYGEQPLYPEPSPPSLADAVRAFTTGQMSAEDFQSVLSGSKVYCPRGETPGFLALHNTQQPVIPMFTSLKELRRYAGKESKYFVITGAEVLDLLPTGYGFVLDMEGDHRIVFDAKSVEQMVDFAMRRMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHR2</accession>
    <name>A0A2G1XHR2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rnpA</name>
        <name evidence="8" type="ORF">BLA24_17955</name>
        <name evidence="9" type="ORF">CYQ11_15320</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50679">
        <property type="protein sequence ID" value="PHQ50679"/>
        <property type="gene ID" value="BLA24_17955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14066">
        <property type="protein sequence ID" value="PPT14066"/>
        <property type="gene ID" value="CYQ11_15320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="142" mass="15136" checksum="453AAA72E6F57A00" modified="2018-01-31" version="1">MLPSESRLRRREDFATAVRRGRRAGRPLLVVHLRSGNTDPHTPGGNAPQVRAGFVVSKAVGGAVVRNRVKRRLRHLVRDRLDQLPAGSLVVVRALPGAGEADHDQLARDLDTALQRLLGGAPRSNPPGGAPRNPGHPGGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHS1</accession>
    <name>A0A2G1XHS1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18545</name>
        <name evidence="2" type="ORF">CYQ11_14735</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50775">
        <property type="protein sequence ID" value="PHQ50775"/>
        <property type="gene ID" value="BLA24_18545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13967">
        <property type="protein sequence ID" value="PPT13967"/>
        <property type="gene ID" value="CYQ11_14735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7434" checksum="CEF2B36BFED90DC7" modified="2018-01-31" version="1">MLDAHELEAESAELLPGREALGKLKFSFTRTTNVTKHVANVAAHNSSTALNVCSPDAVAQSAAGQSISIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHU7</accession>
    <name>A0A2G1XHU7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">BLA24_18870</name>
        <name evidence="7" type="ORF">CYQ11_14410</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50824">
        <property type="protein sequence ID" value="PHQ50824"/>
        <property type="gene ID" value="BLA24_18870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13918">
        <property type="protein sequence ID" value="PPT13918"/>
        <property type="gene ID" value="CYQ11_14410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="81" mass="9005" checksum="644C5BF5AA727742" modified="2018-01-31" version="1">MARVVVDVMLKPEILDPQGQAVQRALPRLGFEGIADVRQGKRFELEVEGPVDDAALARIHEMAETFLANTVIEDFTVRVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI54</accession>
    <name>A0A2G1XI54_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18490</name>
        <name evidence="3" type="ORF">CYQ11_14790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50907">
        <property type="protein sequence ID" value="PHQ50907"/>
        <property type="gene ID" value="BLA24_18490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16568">
        <property type="protein sequence ID" value="PPT16568"/>
        <property type="gene ID" value="CYQ11_14790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="38355" checksum="A173151DF484A240" modified="2018-01-31" version="1">MSLTGTAFFALLIGLCVLAVLATLLLWARLRGPRPVRWLGRIALIALCQATAICVVAVWINSTYGLYASWSDLLGRTDDAGPVAMPGPPAHRAKFTRGDNGMQETYFHGSRSKLSGQVMVWTPPEYRDPRYRHTAFPVVMLLHGVPGSPQSWLEQGRMPGAYERLLRGGATRPFILAVPIINPGGVDTDCSDVHDRKVATWLASDVPELVHEHFRTGPEPRAWGVLGISTGGFCAAKLPLQYPKVFGAGAALDPDPLSGDGGALADPAVRERNSPTRLVRHSRADVGLFLATSRQDRGSPPRYIEEFQREAAGSRVRLKTMLLASGGHNYGTWITLYPAAFGWLGEQLAGGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI77</accession>
    <name>A0A2G1XI77_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">BLA24_18895</name>
        <name evidence="16" type="ORF">CYQ11_14385</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50829">
        <property type="protein sequence ID" value="PHQ50829"/>
        <property type="gene ID" value="BLA24_18895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13913">
        <property type="protein sequence ID" value="PPT13913"/>
        <property type="gene ID" value="CYQ11_14385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="63"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="179"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ50829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT13913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="37286" checksum="441E71980ECE448C" modified="2018-01-31" version="1">MSSETTGASYASAGVDIEAGDRAVELMKQWVKKATRPEAVGGLGGFAGLFDASALKRYERPLLASATDGVGTKVDIARRMGVYDTIGHDLVGMVVDDLVVCGAEPLFMTDYICVGKVYPERVAAIVKGIAEGCVLAGCALVGGETAEHPGLLGADEFDVAGAGTGVVEADRLLGADRIRPGDAVIAMASSGLHSNGYSLVRHVLFDRAGWELDREVPEFGRTLGEELLEPTRIYSLDCLALTRTAEVHAFSHITGGGLANNLARVVPDHLHATVDRSTWTPGAVFDLVGRLGGVERPELEKTLNMGVGMMAVVPQESVDVALATFADRGLDAWVAGEVTERGDDAAAVTLTGDYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIH3</accession>
    <name>A0A2G1XIH3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">BLA24_14680</name>
        <name evidence="10" type="ORF">CYQ11_13390</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948652.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XIH3"/>
    <dbReference type="EnsemblBacteria" id="PHQ51025">
        <property type="protein sequence ID" value="PHQ51025"/>
        <property type="gene ID" value="BLA24_14680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13752">
        <property type="protein sequence ID" value="PPT13752"/>
        <property type="gene ID" value="CYQ11_13390"/>
    </dbReference>
    <dbReference type="GeneID" id="58470329"/>
    <dbReference type="GeneID" id="63982115"/>
    <dbReference type="GeneID" id="67401280"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="13771" checksum="9F9C1621AD40D5A0" modified="2018-01-31" version="1">MPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKPNSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XII2</accession>
    <name>A0A2G1XII2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ORF">BLA24_14740</name>
        <name evidence="13" type="ORF">CYQ11_13330</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030685471.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51035">
        <property type="protein sequence ID" value="PHQ51035"/>
        <property type="gene ID" value="BLA24_14740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13742">
        <property type="protein sequence ID" value="PPT13742"/>
        <property type="gene ID" value="CYQ11_13330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="12784" checksum="5327BDC406014591" modified="2018-01-31" version="1">MEARAQARYIRVTPMKARRVVDLIRGMDATEAQAVLRFAPQAASVPVGKVLDSAIANAAHNYDHTDASSLYISEAYVDEGPTLKRFRPRAQGRAYRIRKRTSHITVVVSSKEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIZ2</accession>
    <name>A0A2G1XIZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51193">
        <property type="protein sequence ID" value="PHQ51193"/>
        <property type="gene ID" value="BLA24_15670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009200">
        <property type="entry name" value="DUF1269_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06897">
        <property type="entry name" value="DUF1269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="199" mass="19462" checksum="0D1BA112486BE237" modified="2018-01-31" version="1">MNDNVLFLNAGSPRKGHRALDALRRAHADGAVTLREGTVIARDAEGALDFPDAADNTGTAPAFAMGGLLGGLLGILGGPLGVLVGFGAGGLIGGLHDVRQATASNAALEMLAAEVPPGSTVLMAEVREEDPAAVDEALAPFGEVRRYPAERVRAEVEAAIAAGRGDAHDAGGAGASGTPRGGAPGGTSDAAPGSTPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ61</accession>
    <name>A0A2G1XJ61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16055</name>
        <name evidence="6" type="ORF">CYQ11_12020</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51263">
        <property type="protein sequence ID" value="PHQ51263"/>
        <property type="gene ID" value="BLA24_16055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13511">
        <property type="protein sequence ID" value="PPT13511"/>
        <property type="gene ID" value="CYQ11_12020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="27937" checksum="3AE13817AE6287A2" modified="2018-01-31" version="1">MTTTPLGAQTAARATAVAARATDLTKVYGQGETQVVALDAVSVEFRQAEFTAIMGPSGSGKSTLMHCMAGLDSVSGGSARIGDTELTALNDKKLTQLRRDKIGFIFQAFNLLPTLTALENITLPMDIAGRKPDRKWLEMVVETVGLSGRLKHRPSQLSGGQQQRVAVARALAGRPEIMFADEPTGNLDSRSGAEVLGFLRNSVRELGQTVVMVTHDPVAASYADRVVFLADGRIVDELHRPTADAVLDRMKRFDAKGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJF5</accession>
    <name>A0A2G1XJF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51353">
        <property type="protein sequence ID" value="PHQ51353"/>
        <property type="gene ID" value="BLA24_15340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="290" mass="33052" checksum="6B8E89848BF8A2BE" modified="2018-01-31" version="1">MASSVNPTVRRRRLGQELRKLRELKGMTAEEVAERLLVSQSKISRLENGRRSISQRDVRDLCSVYGVEDHRIVDSLMQMAKESRQQGWWHAFGDIPYSVYIGLETDAASLRVYEASLVPGLLQTPNYASAVTEGSWPEATVSDVERRVQVRMRRQERITDSDNPLRLWAVIDESALRRIVGSNAIMREQMEHLVEFSLRPHITVQVLPYAVGAHPGMYGKFSILEFHDPQDASTVYLEGITSDLYLEKPNDVQAYSVMYEHLRMQALNAEDSRRFILQVAEDWAAADNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK2</accession>
    <name>A0A2G1XJK2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16395</name>
        <name evidence="3" type="ORF">CYQ11_11680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51380">
        <property type="protein sequence ID" value="PHQ51380"/>
        <property type="gene ID" value="BLA24_16395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16498">
        <property type="protein sequence ID" value="PPT16498"/>
        <property type="gene ID" value="CYQ11_11680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="164" mass="17893" checksum="3831F742ABF1DCBB" modified="2018-01-31" version="1">MDSPVPPPADAGGVPSPTGPRPRHRDRHGRGMRGPIAPPQVPLSVSRAEAFVDLVQDSAERLERRWPQLAAVDFLVREVPSPDDDGPGRSALEALLDGDTVPLGRYVAAHGDAPDRIIVYRRPVEIRTKTRDERALLVHEVVVEQVAELLGLAPESVDPRYGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJP7</accession>
    <name>A0A2G1XJP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_13315</name>
        <name evidence="9" type="ORF">CYQ11_01035</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51484">
        <property type="protein sequence ID" value="PHQ51484"/>
        <property type="gene ID" value="BLA24_13315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11666">
        <property type="protein sequence ID" value="PPT11666"/>
        <property type="gene ID" value="CYQ11_01035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="39138" checksum="A71A9CC0E3877314" modified="2018-01-31" version="1">MNRDLTAHDVIVAGIALASGLLAALVLRVVLRWLAERARRTKWEGDDIIVDVLRTLAPWSAVAGGVGAAAAALPLTHSVGHVVNEVLTTFVILTATVTAARVIGGLVRTVAQSRSGVAGSATIFVNITRIAVMAMGFLVVLQTLGISIAPLLTALGVGGLAIALALKDTLANLFAGVHILVSRTVQPGDYIRLSSGEEGYVVDVNWRNTVVEQLNNNRVILPNAKLAGTNMTNFTRPEQKLSVTVQVGVAYDSDLEQVERVTVEVAEGVMKEVAGAVPDHEPAVRFHTFGESRIGFTVILGVGEFSDKWRIKHEFVKRLHRRYRAEGIRIPVPERTVSLRQGGEAVIPHPRVPLDAVQEHSGPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJT4</accession>
    <name>A0A2G1XJT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13330</name>
        <name evidence="4" type="ORF">CYQ11_01050</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51487">
        <property type="protein sequence ID" value="PHQ51487"/>
        <property type="gene ID" value="BLA24_13330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11669">
        <property type="protein sequence ID" value="PPT11669"/>
        <property type="gene ID" value="CYQ11_01050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="288" mass="31107" checksum="41890E9A7315783C" modified="2018-01-31" version="1">MDVELRHLKALVAIADEGTVTAAAARLHLTQPALSRTLAQLEQRTGVRLVDRGPTGASRRTALTSAGRTLYDHARAILARVDAALADAAAVSRPLRLGYNCALLGRSTTPLLRSWQREHPHVPLELRRRDESTAGLATGDVDVAVVRADPGDPRLRAEALYREDRFAALPDDHPLAGRREIGLAELAGETLVTWREVSTSGPELWRPEERPASGTEVHDVDEWLNAVAVGGTVGIAAEGTVECRTHPGVRYVRVSDAPAATVYLLRPVHPTHPGTEEFVAAVRTLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJZ7</accession>
    <name>A0A2G1XJZ7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pstA</name>
        <name evidence="9" type="ORF">BLA24_12765</name>
        <name evidence="10" type="ORF">CYQ11_17120</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51568">
        <property type="protein sequence ID" value="PHQ51568"/>
        <property type="gene ID" value="BLA24_12765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14360">
        <property type="protein sequence ID" value="PPT14360"/>
        <property type="gene ID" value="CYQ11_17120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="142"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="359" mass="37749" checksum="2C8B079DA1C24A70" modified="2018-01-31" version="1">MSDVTTDKTLAAAAPQRTPTLRQPRLPRWAPAALAAAAAAAGCGIGLGAGLDSRIQWGLMAAVLYVGGMYVLATAVEGRRQAKDRLATSLVWVCFLAAVVPLLSLGWETVSRGSKVLDGAFLSHSMGGVLTIQPGGGVYHAIIGTLEQVGIATAIAAPIGLLTAIYLVEYGRGRLAKAVTFFVDVMTGIPSIVAGLFVLSFWILMLDNGYSGFAGSMALAILMMPVVVRSTEEMLKLVPNELREASLALGVPKWRTILKVVLPTAIGGIATGVMLAVARIAGESAPIVLLVFGSQLINNNPFEGAQSSLPYYIYEQWAAGNEASYDRAWAAALVLIAFVMILNLVARGIARWKAPKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK13</accession>
    <name>A0A2G1XK13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_12915</name>
        <name evidence="11" type="ORF">CYQ11_17275</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51594">
        <property type="protein sequence ID" value="PHQ51594"/>
        <property type="gene ID" value="BLA24_12915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14387">
        <property type="protein sequence ID" value="PPT14387"/>
        <property type="gene ID" value="CYQ11_17275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="577" mass="62528" checksum="A4DD5BF07CB58B3F" modified="2018-01-31" version="1">MLVRLLRAHLRPYSGAITLVVLLQLVQTLATLYLPTLNADIIDKGVVKGDTGYILGTGGVMIAVTLAQIVCSIGAVYYGARTAMAIGRDLRGAVFDRVQSFSAREMGQFGAPSLITRTTNDVQQVQMLALMTFTLMVSAPIMCVGGIVMALNQDVPLSALLLAIVPVLATIVGLIIRRMRPVFRGVQERIDTVNRVLREQITGIRVIRAFVRDTHERKRFEGANSDLMDVSLKAGRLMALMFPSVMLVVNLSSVAVVWFGGHRIDSGGMQIGAMTAFLSYLMQILMAIMMATFMFMMVPRAEVCAERIQEVLTTESSVVPPAAPVTRLRGRGHLELRGVEFRYPGAEEPVLRDVSLAARPGETTAVIGSTGSGKSTLLGLVPRLFDATAGDVLVDGVNVREIDQSAMADAVGLVPQKPYLFSGTIASNLRYGRPEATDEELWQALETAQAREFVEAMEGQLEAPVAQGGTNVSGGQRQRLAIARALVRKPEIYLFDDSFSALDYATDARLRAALARETGDATVLIVAQRVSTIRDADRIVVLDEGRVVGTGTHTELMGTNETYREIVLSQLTEEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK25</accession>
    <name>A0A2G1XK25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12715</name>
        <name evidence="3" type="ORF">CYQ11_17070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51560">
        <property type="protein sequence ID" value="PHQ51560"/>
        <property type="gene ID" value="BLA24_12715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14351">
        <property type="protein sequence ID" value="PPT14351"/>
        <property type="gene ID" value="CYQ11_17070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7474" checksum="952EE13DD9EB58BF" modified="2018-01-31" version="1">MAELDWIKAAEEGDTEYFEVAFGDDGNVHIRLNTDPENVVVTTDAKWEAFVLGVKAGEFDHFVEGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK42</accession>
    <name>A0A2G1XK42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13455</name>
        <name evidence="3" type="ORF">CYQ11_01175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51509">
        <property type="protein sequence ID" value="PHQ51509"/>
        <property type="gene ID" value="BLA24_13455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11691">
        <property type="protein sequence ID" value="PPT11691"/>
        <property type="gene ID" value="CYQ11_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="404" mass="44376" checksum="CDBD46F8C6B10515" modified="2018-01-31" version="1">MSHPDALIPVPEVEPGTAGPPCAYARLRAEAPVVKAQLPNGETGWLLSRYEDVRAAFADPRLVRPLLSAWPPREGDDAPPPCLPTFLEMTGEHHERVRRTVLPMFGRRRLEFMEPRIRAMAGELVDAMVAGAEDGTADLVAAYAEPLPLRVLCETVGLPYEDRDVYLPHTLALLGAAGLTMEEVLAALYALQDYAGELISRKEKEDGEGEDYIRLLLAEARRPGSELTRDDVVSFVVTMLMAGYKTNIQHTGNALLALLTHPEQMRTLREAPERTSTAVEELLRYVPLMNAINILVATEDFTLHGQRIRAGDAVVPVPASANRDPEAFAEPDRLDLTRTPNAHVAFGHGPHACTGGHLTRMQLAIAIQVLLERLPGVELAVPAKTIPWDESTPLRAPARLPVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK60</accession>
    <name>A0A2G1XK60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2516 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12790</name>
        <name evidence="4" type="ORF">CYQ11_17145</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51628">
        <property type="protein sequence ID" value="PHQ51628"/>
        <property type="gene ID" value="BLA24_12790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16618">
        <property type="protein sequence ID" value="PPT16618"/>
        <property type="gene ID" value="CYQ11_17145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="114" mass="12281" checksum="DCFFE5F4DFF43124" modified="2018-01-31" version="1">MLVEGFGEVMYWVSIGLLVFTLVAFIDAALHREDAYRAADKNTKGFWLIILGLAAAVNLFFGILSFLPILGLIATIVYMVDVRPALRQASGRGGRGRRGGSSSDGPYGPYNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKF6</accession>
    <name>A0A2G1XKF6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF998 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11550</name>
        <name evidence="4" type="ORF">CYQ11_02785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51718">
        <property type="protein sequence ID" value="PHQ51718"/>
        <property type="gene ID" value="BLA24_11550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11967">
        <property type="protein sequence ID" value="PPT11967"/>
        <property type="gene ID" value="CYQ11_02785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="27013" checksum="45E1CD10742BE08D" modified="2018-01-31" version="1">MPDPYTAARRAAAVTERRPRRRRTAPPSAWAPLLLVAAAAVYNDWLLEFVLPTGLDARHSYVSELYAADQPFHRLFGGIEVVAATLVISGALLARRRTPGGPATAGWWALVAFGVFSVADVVVPMHCAPSVESPCEAVNPWHTTTSALVHAALFASMALLIIAARPGRPLWPEVGRRGPWVLASALTTALATVGPLFGRPGWHGVPQRAHLVLVGVWFLLLATALRAEARRDGNRAVGVGSGGRPAGEVARPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKY7</accession>
    <name>A0A2G1XKY7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10755</name>
        <name evidence="3" type="ORF">CYQ11_00795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51924">
        <property type="protein sequence ID" value="PHQ51924"/>
        <property type="gene ID" value="BLA24_10755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11631">
        <property type="protein sequence ID" value="PPT11631"/>
        <property type="gene ID" value="CYQ11_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="112" mass="12590" checksum="B206AAF3FAAF9784" modified="2018-01-31" version="1">MGTDELILSQAQELRRGTVVLACLALLEEPQYGYALLETLGDAGIAVDGNTLYPLLRRLEKQGLLISEWNTDESRPRKFYRVSPEGTRVRTGLLREWQDLGASISRLTKGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLB7</accession>
    <name>A0A2G1XLB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_10570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000124">
        <property type="protein sequence ID" value="PHQ51971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51971">
        <property type="protein sequence ID" value="PHQ51971"/>
        <property type="gene ID" value="BLA24_10570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="3">
        <location>
            <begin position="123"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="267" mass="28925" checksum="2275A19730034312" modified="2018-01-31" version="1" fragment="single">MVLAGAGVGGGSLNYANTLYVPPKAFFEDPQWAGITDWEDELRPHYAQARRMLGVRLNPTVTASDAHLKAAAERMGVGDTFHMAPVGVFFGDGDDADGARRARPGEEVPDPYFGGAGPARTACTECGECMTGCRHGAKNTLNENYLHLAERAGAVLRPMTTVVAVSEHRDGGFRVVTVPTDRRRKARPRVLRAERVVLAAGTYGTQTLLHTMRDKGLLPRVCDRLGVLTRTNSEALVGAQTTDRRYRKAHGAARADFTRGVRSPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLH4</accession>
    <name>A0A2G1XLH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09330</name>
        <name evidence="3" type="ORF">CYQ11_27940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52114">
        <property type="protein sequence ID" value="PHQ52114"/>
        <property type="gene ID" value="BLA24_09330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16194">
        <property type="protein sequence ID" value="PPT16194"/>
        <property type="gene ID" value="CYQ11_27940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="197"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="383" mass="40705" checksum="2656764FD2F7F675" modified="2018-01-31" version="1">MSALPVPPLVDQHCHGVVRGDPDDDLFASFLTESDLPAADGTSFFDTQLGFAVRRWCPPLLDLEPHCPPARYLDRRRELGGAEATRRLLGACGIADYVVDTGLGRPGELLAPRELAAAAGGAGSHEVVRLERLAEGLADRAGGLSSFLDELATGVPAAARTAVAFKSVIAYRHGLDFAPEPPAPAEVRRAADRWLVGRAPGDRLTDPVLMRHLLWSAAETALPVQLHTGFGDPDLRLHRCDPLLLTDFARAVRPTGCALVLLHGYPFHRGAGYLAHAFPHVYADVGLALTHTGARAGAVLAEMLELAPFDKLMFSTDAYGLPELYVVGAELFRRGLSRLLTGWVDEGAWSSGDAERVAAMVAAGTARRVYGLAPGDGASASFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLP9</accession>
    <name>A0A2G1XLP9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09420</name>
        <name evidence="4" type="ORF">CYQ11_28030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52130">
        <property type="protein sequence ID" value="PHQ52130"/>
        <property type="gene ID" value="BLA24_09420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16210">
        <property type="protein sequence ID" value="PPT16210"/>
        <property type="gene ID" value="CYQ11_28030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="76"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="209" mass="22380" checksum="3D5893373E25BA25" modified="2018-01-31" version="1">MTGIHPAFHPLFDGSGIDGGLYTDITRDAQRAPWLLNDTVATWSAFGLALFAALMLTGWWRARRSDSPMMARALATPLVVAVVYGVDVVLKSLVREERPCRSLPGSFTLEACPAPHDWSFPSNHAVIAFAAATALWLVDRRLGAVAVTAAVAMAASRVWVGVHYPHDVAAGALMGIALAVPLTVGATRATPWVERAREGRLRPFLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM61</accession>
    <name>A0A2G1XM61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000090">
        <property type="protein sequence ID" value="PHQ52300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52300">
        <property type="protein sequence ID" value="PHQ52300"/>
        <property type="gene ID" value="BLA24_08370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013787120" evidence="1">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="100" mass="10267" checksum="763163A1EBB88C68" modified="2018-01-31" version="1">MLLALALVLVPVALLAQVARLVAALSLEYQPSGFQFELASSSLPVLLAVLGDRSGGAAAAAPAVPANISPAVASAITGTRRKFLDSHVRFLSVLSRFAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT0</accession>
    <name>A0A2G1XMT0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-D-S-L family lipolytic protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07285</name>
        <name evidence="4" type="ORF">CYQ11_27440</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52564">
        <property type="protein sequence ID" value="PHQ52564"/>
        <property type="gene ID" value="BLA24_07285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16102">
        <property type="protein sequence ID" value="PPT16102"/>
        <property type="gene ID" value="CYQ11_27440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="198"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="403" mass="43069" checksum="72739533D4AD6385" modified="2018-01-31" version="1">MTVQGRDSETAVLTTEETATRWSAGWSAPVQQPSSGFEENWSEKGFDHQSVRQVVRVTGGGTAARIRLSNRFGAKPLTVTAATLALAAEGAALRPGTLREVTFGGSRTVVVPAGGERVSDAVDVRVERFDGVAVTLFFAGATGPATFHAQAYTDSYRATGDRTGETGDEGFEERTHSWYYLSDVELSGEGAVRETVVAFGDSITDGFGSTVGADRRYPDALAERLAADGGAWGVVNAGIGGNLVLHDSPWYGERAVGRFERDVLDRPGVRSVIVFAGLNDIGFSEVDLPTYKPDPDVDVAQLIAGYRDLIRRAHARGVRVVGATMLPFKGAEYHTPRAEAKRVALNEWIRTSGEYDAVADFAAALAAPGDEESLDAAYDSGDHKHPNDAGYRVMAHAVDLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMV8</accession>
    <name>A0A2G1XMV8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07235</name>
        <name evidence="3" type="ORF">CYQ11_27390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52556">
        <property type="protein sequence ID" value="PHQ52556"/>
        <property type="gene ID" value="BLA24_07235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16094">
        <property type="protein sequence ID" value="PPT16094"/>
        <property type="gene ID" value="CYQ11_27390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045652">
        <property type="entry name" value="DUF6397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19934">
        <property type="entry name" value="DUF6397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="350" mass="37408" checksum="DDFE64007B608958" modified="2018-01-31" version="1">MEESVPLARAARELGLKPREFELAVQLGEVRTVASGPGGRRRVAREEIERHRATEAFPEALRTRLWVVGTTEGAELLGISPGRFTRLAKAGCFAPVRFYVNRYRVVVWHYLTADLVEFADRSPDLLSGRTPAPLRAVLEKHPDRRARGWRARRLDQLTAQAEDPWQRAAVPAAVLGSDDLADAVPDPGERAYLSALRPALVPARPVTGPARDVVDELVLAQDEDEIEWHRHCLTAALAEARALGPASPAGGVPPGTVAAGTSAASLEQALRTEPSVPVLSSTRSVLSAPPAPSAPLERPVPSGAGVGGPPRQAGPSGPSGPGRPGLPGLWRRLRRRGGRRGPAVRAGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMZ0</accession>
    <name>A0A2G1XMZ0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="20">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="20">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 25" type="primary">lysS</name>
        <name evidence="24" type="ORF">BLA24_07145</name>
        <name evidence="25" type="ORF">CYQ11_27300</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 26">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="25 27" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 27">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="20">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the LPG synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="20"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52541">
        <property type="protein sequence ID" value="PHQ52541"/>
        <property type="gene ID" value="BLA24_07145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16079">
        <property type="protein sequence ID" value="PPT16079"/>
        <property type="gene ID" value="CYQ11_27300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="17" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 20 24" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="23">
        <location>
            <begin position="806"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1033"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PHQ52541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PPT16079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1121" mass="122135" checksum="24CB31E680DA3BB2" modified="2018-01-31" version="1">MSRTTRDGGTATVPETTVRETAGAGERTTAWRRFLHRVPNGFALFFALLGVFCAITALIPPLRRVATPVTDAMDLLTVPTAPNLAYAVFLLLLAAAMAARKRVTLWFVLAYLTLLLLADALLLSVGYWDMIPSTSVSAAAIVLLVLARREFYAASRRGAFLRALLVLVAGLAVAILVGWGLVSLFPGTLEPGGGNRLLFVANKVCGGLVSGRHFDGHPPHWLYFLLGLFGALALLNAAMALFRSQRLVAALHDDEEPRIRALLGRYGARDSLGYFATRRDKAVVFSPSGKGAVTYRVEAGVCLASGDPLGDPEAWTPAIEAWLGVAGRYGWQPAVMGASEEGAKAYARSGLGALQLGDEAVLQVSSFDLEGREMRVTRQAVHRVERTGATVRVRRHSALSDEEMGEVIRRADAWRDTETERGFSMALGRLGDPADGDCLLVEAFDNEGTMIALLSFVPWGADGVSLDVMRRDRAAPNGVMEFMVARLCAQAGRFGVKRISLNFAVFRSAFEEGARIGAGPVLRLWRKLLLFFSKWWQLEALYRSNVKYNPEWHPRFLCYADAGALARIGLAAGIAEGFVAVPSLGKLWRRGRPRGIASPASTAGLPSLSELGFVPGAGTGAEAGDETAGLPEQVRVRRRKLERLRAAGVDPYPVDAHRTHTLAAVRAAHPGLPPASRTGARVTVTGRVLLIRNHGGVAFALLRDWSGDLQLVLTRDGSGDELLRRFSAHVDLGDHVEAEGEVGTTDRGELSVFVTRARMTAKCLRPLPDKRHGLSDPEARVRMRYVDLAVSPGARRTVRARSAAVQALRQGLLARGFLEVETPMLQQVHGGANARPFTTHINAYDLDLYLRIAPELYLKRLCVGGMEKVFELGRTFRNEGISYKHNPEFTMLEAYQAFADYDVMLDLTRELIQEAAVAAHGSAVAVRVDGDGKRTEHDISGVWPVKTVYGALSEALGREIGADTPTEALRACCDAVGVPHRPEDGRGDVVLEMYERLVEERTTLPVFYKDFPTDVSPLTRPHRGDARLAERWDLVAFGTELGTAYSELIDPVEQRRRLTAQSLLAAGGDPEAMELDEDFLRALEYAMPPTGGLGLGVDRLVMFLTGLSIRETLPFPLVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN35</accession>
    <name>A0A2G1XN35_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_07260</name>
        <name evidence="11" type="ORF">CYQ11_27415</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52559">
        <property type="protein sequence ID" value="PHQ52559"/>
        <property type="gene ID" value="BLA24_07260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16097">
        <property type="protein sequence ID" value="PPT16097"/>
        <property type="gene ID" value="CYQ11_27415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="44"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="356"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="389"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="593" mass="63669" checksum="87E1F9748006061C" modified="2018-01-31" version="1">MIGVAPPAYDPAAPESAATLPVAGPATVRRYVKDLLRRHRRAFALLVTVNAVAVVASTVGPYLLGGLVEDLSSGAEELHLGRTVALFAAALAVQALFVRMVRLRGAVLGERMLADLREDFLVRSVALPPSVLERAGTGDLLSRITTDVDRLANAMREAVPQLTIGFVWVGLLLGALTVTAPPLALCVLVGLPLLLAGSRWYFRRAPGAYRSEAAGYAAVAASLAETVDAGRTIEAHRLGRRRVELSDRRVDEWVRWERYTLWLRSVLFPVINVTHVLLLGSVLVIGGEFVLQGWLSVGRLTTGALLAQMLVEPIGLILRWYDELQVALVSLARLVGVHEIEPDDTDELVSPKGRQVRADEVRFGYPTGGDVLHGVSLDVRPGSRVALVGPSGAGKSTLGRLLAGIYAPRSGTVTLGDAELSRMPTERVRRHVALVNQEHHVFVGSLRDNLLLARTDAGDGELWAALGAVDADVWARALEEGLDTEVGSGGHTLTPAQAQQIALARLVLADPHTLVLDEATSLLDPRAARHLERSLAKVLEGRTVVAIAHRLHTAHDADVIAVAEDGRISELGSHDELVAADGAYAALWRSWHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN40</accession>
    <name>A0A2G1XN40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000080">
        <property type="protein sequence ID" value="PHQ52630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52630">
        <property type="protein sequence ID" value="PHQ52630"/>
        <property type="gene ID" value="BLA24_06430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="45" mass="4836" checksum="6DCD541476F201DA" modified="2018-01-31" version="1">MAAFVASHAGLLYFVGAEQGATALISARRAEWVHDGRHLLGFPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNS2</accession>
    <name>A0A2G1XNS2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04805</name>
        <name evidence="3" type="ORF">CYQ11_28725</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52887">
        <property type="protein sequence ID" value="PHQ52887"/>
        <property type="gene ID" value="BLA24_04805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11454">
        <property type="protein sequence ID" value="PPT11454"/>
        <property type="gene ID" value="CYQ11_28725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="56" mass="6306" checksum="5956385CCD25D223" modified="2018-01-31" version="1">MVPLLLVLLLALLLFGAGFAIKVLWWFAVAVLVIWLLGFVMRSAGTGGSRGRWYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNT8</accession>
    <name>A0A2G1XNT8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_04765</name>
        <name evidence="7" type="ORF">CYQ11_28770</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52880">
        <property type="protein sequence ID" value="PHQ52880"/>
        <property type="gene ID" value="BLA24_04765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11461">
        <property type="protein sequence ID" value="PPT11461"/>
        <property type="gene ID" value="CYQ11_28770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="105" mass="11857" checksum="9E230603D0D92FE8" modified="2018-01-31" version="1">MTERLPPQANGSANLADILERVLDKGVVIAGDIRVNLLDIELLTIKLRLVVASVDKAREMGIDWWESDPALSSGARRRELGEENARLRARVAELEQEEQREEEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNZ4</accession>
    <name>A0A2G1XNZ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52958">
        <property type="protein sequence ID" value="PHQ52958"/>
        <property type="gene ID" value="BLA24_05275"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00638"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1742"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2813"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3887"/>
            <end position="3962"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1017"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1777"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2848"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="4811" mass="508130" checksum="874EDAF0FCCF8C4B" modified="2018-01-31" version="1">[encoded data, 4811 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP40</accession>
    <name>A0A2G1XP40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_04355</name>
        <name evidence="5" type="ORF">BLA24_04370</name>
        <name evidence="3" type="ORF">BLA24_15400</name>
        <name evidence="6" type="ORF">CYQ11_12675</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000067">
        <property type="protein sequence ID" value="PHQ53001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000067">
        <property type="protein sequence ID" value="PHQ53002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51357">
        <property type="protein sequence ID" value="PHQ51357"/>
        <property type="gene ID" value="BLA24_15400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53001">
        <property type="protein sequence ID" value="PHQ53001"/>
        <property type="gene ID" value="BLA24_04355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53002">
        <property type="protein sequence ID" value="PHQ53002"/>
        <property type="gene ID" value="BLA24_04370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16519">
        <property type="protein sequence ID" value="PPT16519"/>
        <property type="gene ID" value="CYQ11_12675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="145"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="314" mass="31537" checksum="A0148A6C8CAFF39E" modified="2018-01-31" version="1">MAFFGSAFTSSKVVVGHVPHQVAAALRFGGGALILVLILAVAARGGRIGSFSWRDAVRAGLVGLLGVFAYNVFFFWGLSLAPSIDGSIIVPVLSPVLTTGALLVMGRETASTARVVGLVLGVAGAVVFFLGIGDGGGGVSGKRLLGDAVYLLGAAAWAAYSITSKRVLAGMEPLRATTYGTVAGALGLVVLAVPSVPDVDWGGLSGGVWANVVYLAIGPTAIAYLCFYRGLRSVSPSTATVVMFAVPVFGVTSSGIFLDESFTAVQVVGGVIMLVGALLAVTQGRFLRRPGGRTAAAPAAAAPAVAAPRDAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP96</accession>
    <name>A0A2G1XP96_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Branched-chain amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04030</name>
        <name evidence="4" type="ORF">CYQ11_07285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53054">
        <property type="protein sequence ID" value="PHQ53054"/>
        <property type="gene ID" value="BLA24_04030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12716">
        <property type="protein sequence ID" value="PPT12716"/>
        <property type="gene ID" value="CYQ11_07285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305614" evidence="1">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="44"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="413" mass="43951" checksum="D5998904DC9941A0" modified="2018-01-31" version="1">MRHRPFLLLTTTLTTCALALSACGSRDPQKAGDAAGDAAGKTVVAIGVDAPLTGSVSAIGQGIKNSVDLAVRTANKYGEVKGITFKTVALDDQAVPGTGQQNAAKLAADKTVLGVVGPYNSGVAQSMQGIFAKSHLTQVSPANTNPALSLGDAWAKGDKKRPFPTYFRTATTDLVQGRFAAQYYYNESKKRRVFVVDDKQTYGMGLAAIFAQEFKHLGGQVVGTDHLTVKETDFSGIANKVKSSGADSVYFGGQYPEGGLLSDQVKKTGAHIPLMGGDGMYDPAFITASGESNDGDLVTSVGYPVEELHSARTFIKNYKKTGYKDPYASHGGYSYDAAWAIIQAIKKTVQDNDGKLPENPRPKIVEAMSDVYFGGVTGKVSFDEYGDTTNKQMTVYQVAGKIWKPIKSTTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPC8</accession>
    <name>A0A2G1XPC8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000064">
        <property type="protein sequence ID" value="PHQ53009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53009">
        <property type="protein sequence ID" value="PHQ53009"/>
        <property type="gene ID" value="BLA24_04270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="70"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="210" mass="22845" checksum="8F7EF8F74A388094" modified="2018-01-31" version="1">MEARQQRRVVPDRAQRQAHGVGPAERGPDLQPPARHPVHRRRRRPRPRRARHQARQGVVVPHHGFGRRTTAPNTRYLLNNGGTGNAAEIWGGRTADGTVLVGSRTNGYAGQQWYFDDAGSGYQRIRSAVSGKCLQLGGPAGAGTWVAQQPCGNADSQKWRLSPKGSGVTVAAKSGNYVLGVSNRPYYGSWLLELQSPDGRAAQVWAVQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPQ5</accession>
    <name>A0A2G1XPQ5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">BLA24_02365</name>
        <name evidence="9" type="ORF">CYQ11_04730</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53200">
        <property type="protein sequence ID" value="PHQ53200"/>
        <property type="gene ID" value="BLA24_02365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12292">
        <property type="protein sequence ID" value="PPT12292"/>
        <property type="gene ID" value="CYQ11_04730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="161" mass="16884" checksum="C4BEA0157FFC979B" modified="2018-01-31" version="1">MSGKGAPELSVKNCQDLRVAVIAAQWHEKVMDGLVDGSLRALHELGIDEPTLLRVPGSWELPVVAKVLAGRGYDAIVALGVVIRGGTPHFDYVCQGVTQGLARVSADTGVPVGFGVLTCDTEEQALDRAGLEGSAEDKGHEAVTAAVSTAMTLRSVSEPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPQ8</accession>
    <name>A0A2G1XPQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Riboflavin synthase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_02380</name>
        <name evidence="5" type="ORF">CYQ11_04745</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53203">
        <property type="protein sequence ID" value="PHQ53203"/>
        <property type="gene ID" value="BLA24_02380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12295">
        <property type="protein sequence ID" value="PPT12295"/>
        <property type="gene ID" value="CYQ11_04745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="203" mass="21306" checksum="6441E61240574C9C" modified="2018-01-31" version="1">MFTGIVEELGEVVAVEELGDSSRFRLRGPVVTADAKHGDSIAVNGVCLTVVETADGTFTADVMAETLNRSSLGALAPGSRVNLERPMALGGRLGGHLVQGHVDGTGTITERVPGEHWEIVKVALPAGLARYVVEKGSITVDGVSLTVVEAGDDYFTVSLIPTTLELTTLGTKQPGDPVNLEVDVLAKYVERLLGQRGEKETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPW5</accession>
    <name>A0A2G1XPW5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">BLA24_02840</name>
        <name evidence="11" type="ORF">CYQ11_05135</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53266">
        <property type="protein sequence ID" value="PHQ53266"/>
        <property type="gene ID" value="BLA24_02840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12360">
        <property type="protein sequence ID" value="PPT12360"/>
        <property type="gene ID" value="CYQ11_05135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="420" mass="45850" checksum="7E50846712DC3356" modified="2018-01-31" version="1">MSTFKAPKGTYDLIPPDSAVYLAVREAISSPLKRAGYGYIETPGFEQVELFSRGVGESTDIVTKEMYTLTQRGKEQLALRPEGTASVLRAALEANLHKSGNLPVKLWYSGSYYRYERPQAGRYRHFSQVGAEAIGAEDPALDAELIILAVDAYKSLGLTNFRLLLNSLGDKECRPAYRDALQAFLRDLDLDEDTRRRVEINPLRVLDDKREDVQKQLAGAPMLRDHLCEACKEYHEQVRELLTAAGVAFQDDEKLVRGLDYYTRTTFEFVHDGLGSQSAVGGGGRYDGLSEMIGGPALPSVGWALGVDRTVLALKAEGVELELPAPTQVFAVPLGEEARRVLFGVVTELRRAGVATNFAFGGKGLKNAMKSANRSGARFALVAGERDLAEGMVQLKDLESGEQKAVALDTVVSEVLSAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ01</accession>
    <name>A0A2G1XQ01_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_03100</name>
        <name evidence="8" type="ORF">CYQ11_05400</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53306">
        <property type="protein sequence ID" value="PHQ53306"/>
        <property type="gene ID" value="BLA24_03100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12403">
        <property type="protein sequence ID" value="PPT12403"/>
        <property type="gene ID" value="CYQ11_05400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305618" description="Lipoprotein" evidence="6">
        <location>
            <begin position="29"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="30406" checksum="AFD7AA1BAFEBD5CD" modified="2018-01-31" version="1">MRTTVKFTAAAAAAAALTLGLSACSAPSDTSSSGSSKKGKDADPAAELVVAASPTPHGDILNFVRDNLAAKAGLKLKVREFNDYVLPNTATQNGEVDANFFQHKPYLDDFNKKNKTDIVPVVNVEVEPLGLYSKKGKKVADLTSGSTIAVPNDTTNEGRALKLLADNGVIKLKDGVGAEAKLSDVEDKKGVQFTELEAAQIPSRLADVDAAVINGNFAINAKLNPAKDSIALEKAEGNPYANFLAVKRGNEGDPRVAKLAKLLNSDEVKKFIEEKFNGAVIPAFGAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ03</accession>
    <name>A0A2G1XQ03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02000</name>
        <name evidence="2" type="ORF">CYQ11_04360</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53327">
        <property type="protein sequence ID" value="PHQ53327"/>
        <property type="gene ID" value="BLA24_02000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16346">
        <property type="protein sequence ID" value="PPT16346"/>
        <property type="gene ID" value="CYQ11_04360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="29956" checksum="5004BF96C5628842" modified="2018-01-31" version="1">MRAASGTVTPADAADAARLIAFGLQPKLQPARDAEYAELLQRHRDDPAFARLADAVAAGLGLVVLEVSTRAGMAVTAAEDSVFAVRMGDYARRATVDSGDRFLHGLAHLAVAAMAFPRPEDLADDGYIGRVSVNGVDTFVRQACRRLEERAAEQGENTDPATGAPGLEAAWRVYARRSATGATKDARRLAGSTTGIIAKAVAFLVDSGFLQRTGDDSGGTFRTTARYQLQVRDMGGGAAMTELLELGVVPVGDGSATLLPPDDADVLDLVADAGLPFFDNQHSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ45</accession>
    <name>A0A2G1XQ45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01765</name>
        <name evidence="4" type="ORF">BLA24_01780</name>
        <name evidence="2" type="ORF">BLA24_25555</name>
        <name evidence="5" type="ORF">CYQ11_20515</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000032">
        <property type="protein sequence ID" value="PHQ53358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000032">
        <property type="protein sequence ID" value="PHQ53359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49735">
        <property type="protein sequence ID" value="PHQ49735"/>
        <property type="gene ID" value="BLA24_25555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53358">
        <property type="protein sequence ID" value="PHQ53358"/>
        <property type="gene ID" value="BLA24_01765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53359">
        <property type="protein sequence ID" value="PHQ53359"/>
        <property type="gene ID" value="BLA24_01780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16691">
        <property type="protein sequence ID" value="PPT16691"/>
        <property type="gene ID" value="CYQ11_20515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="27367" checksum="E7F9229520E03607" modified="2018-01-31" version="1">MTTTTTIASQTTSSARPLTGRVAVVTGASSGIGEATADLLAAQGAHVALLARRGDRLAEHVARIEAAGGTALAVPSDVTEPVSIADAATRVRERFGHVDLVVNNAGLALPDLLGQAAGTNWQRMIEVNVTGAWAVVDAFVPDLLAAAADRGHADLVTISSVAAQTVLPGFGGYAASKAALSHLSRNLRTQLAPSDVRVTTIEPGAVDTELRDHIDDPAISAAVQEAMDSIEKIPSGADVAELIAFAVSRPRHVNLSQISVLPSREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ97</accession>
    <name>A0A2G1XQ97_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000020">
        <property type="protein sequence ID" value="PHQ53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53402">
        <property type="protein sequence ID" value="PHQ53402"/>
        <property type="gene ID" value="BLA24_01370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="284" mass="30542" checksum="471BB9681FD81975" modified="2018-01-31" version="1">MSVSASAMSRTLGRLRRVLGDPLLVPAGRGLTLTPRALELRPRVEAALVGALAALQPVQPVDIASVERRFTLRTNDGLAVVLGPALAERVAMEAPGIQLRWLPEGDEDPADLRGAIDLDIGHLPDLPHDVRSRPLARHRHVAVCRAGAPHADEPLTVERFAALPHITVTRRGRFHSVVDERLAELGLRRRVLATVPTHITACFLALRSDVLALLAAPVAARAAEAMPLVVREIPLPLPSIATGMAWHVRVDADPAHRWLRDAVAQAESPGPEDTRPAPEAAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQA5</accession>
    <name>A0A2G1XQA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00385</name>
        <name evidence="6" type="ORF">CYQ11_07395</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53427">
        <property type="protein sequence ID" value="PHQ53427"/>
        <property type="gene ID" value="BLA24_00385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12731">
        <property type="protein sequence ID" value="PPT12731"/>
        <property type="gene ID" value="CYQ11_07395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="226" mass="24155" checksum="F217C693DD4E6256" modified="2018-01-31" version="1">MAITVVIADDQEMVRTGFRMILESQPDIEVVADVVDGEAALAAVEHHDPDVLLLDIRMPKLDGLEVTRRLSALAAAHPERGQRPRVVIVTTFDLDEYVHQALRNGASGFLLKDASPAMLVEAVHAAAVGDSLISPAITVRLLRDMAPGVGTAGTLRQPAEPLTDREADVVRCLARGATNAEIASELFVSLSTVKTHLANVQTKLDARNRVEIAAWAWESGLATGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQI9</accession>
    <name>A0A2G1XQI9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4126 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00830</name>
        <name evidence="4" type="ORF">CYQ11_07840</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53508">
        <property type="protein sequence ID" value="PHQ53508"/>
        <property type="gene ID" value="BLA24_00830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12813">
        <property type="protein sequence ID" value="PPT12813"/>
        <property type="gene ID" value="CYQ11_07840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="20205" checksum="E0D5921762328DAD" modified="2018-01-31" version="1">MSVLPLVFTSGWASGINAYAVVLLLGVLGATGVSDDVPGALQRPDVLIAAGVLFLCEAVADKVPYVDTVWDVVHTVVRPVAGGVVGALLAGQTGSVPELAAGALGGSAALLSHLVKAGTRMAVNTSPEPASNIALSLGEDLGVAALIVFALFHPVAAAVVAGTLLALGVALVAFLWKRVRAFLRRRRERRAARLSGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQL6</accession>
    <name>A0A2G1XQL6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ORF">BLA24_00850</name>
        <name evidence="14" type="ORF">CYQ11_07860</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53512">
        <property type="protein sequence ID" value="PHQ53512"/>
        <property type="gene ID" value="BLA24_00850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12817">
        <property type="protein sequence ID" value="PPT12817"/>
        <property type="gene ID" value="CYQ11_07860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="12">
        <location>
            <begin position="14"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="22881" checksum="30A10FBB9C1CD34D" modified="2018-01-31" version="1">MPDSARQRLADARLYLCTDARKRQGDLPEFLDAVLSAGVDIVQLRDKGMEAGEELEHLAVLAEAARRHGRLLAVNDRADVAHAAGSDVLHLGQGDLPVPAARALLGDDVLIGRSTHAESEVEAAITEPGVDYFCTGPCWPTPTKPGRHAPGLSLVRHAAALAPARPWFAIGGIDAGNLDEVLDAGARRVVVVRAITEADDPGDAAAALAKRIRAYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X993</accession>
    <name>A0A2G1X993_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_30285</name>
        <name evidence="9" type="ORF">CYQ11_23380</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47803">
        <property type="protein sequence ID" value="PHQ47803"/>
        <property type="gene ID" value="BLA24_30285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15428">
        <property type="protein sequence ID" value="PPT15428"/>
        <property type="gene ID" value="CYQ11_23380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="67"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="299" mass="32168" checksum="80F5C9CE9A9D715B" modified="2018-01-31" version="1">MSGSVLYDVPGPKARVRNRIYGALSTVALLGLIGFVLYRLDDTGQFQAGLWDDYEYTETQQRIVDGLVTTLKTFAIAAVLSLVLGTVLAAARLSDHKPVRWAAAVVVEFFRAMPLLIMIFLLYAAVFTSDPMWALVIGLTLYNGSVQAEIFRSGINAVPRGQSEAAYAIGLRKTQVMTSVLVPQAVRSMLPSIISQLVVTLKDTSLGFIILYEELLFVGKSFAQQTPPVNGVYAFIPMVIVFGSIYILLCLALSSVATWIERRTKRSRKGTPPAMPLNGAALTAETTAGGAGADGVQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9F2</accession>
    <name>A0A2G1X9F2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF3071 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30620</name>
        <name evidence="3" type="ORF">CYQ11_23715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47864">
        <property type="protein sequence ID" value="PHQ47864"/>
        <property type="gene ID" value="BLA24_30620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15489">
        <property type="protein sequence ID" value="PPT15489"/>
        <property type="gene ID" value="CYQ11_23715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="363" mass="39624" checksum="C298E4D63D4B34D9" modified="2018-01-31" version="1">MTSAGTTREVPMPELRVVAVSNDGTRLVLKAADSTEYTLPIDERLRAAVRNDRARLGQIEIEVESHLRPRDIQARIRAGASAEEVAQLAGIPVERVRRFEGPVLAERAFMAERARKTPVRRPGENAGGPPLGEAVAERLVLRGADKDTAQWDSWRRDDGTWEVLLVYRASGEPRAASWTYDPPRRIVQALDDEARALIGETDDTPEPSFPFVPRIARLPRDRPLDRSADRQTAPTEAEVPSAASSPEDPGPREKERDSLTSLLEAVPSFRGDMVVPDTTPTVPPPASDPAAEEADVAEPPAPAASAGSAYADVLMPRSVAGHRDRLIGTTDRQAEADGVRPGRRAAVPSWDEIVFGTRRKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9G4</accession>
    <name>A0A2G1X9G4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PaaI family thioesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30675</name>
        <name evidence="4" type="ORF">CYQ11_23770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47874">
        <property type="protein sequence ID" value="PHQ47874"/>
        <property type="gene ID" value="BLA24_30675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15499">
        <property type="protein sequence ID" value="PPT15499"/>
        <property type="gene ID" value="CYQ11_23770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="194" mass="20409" checksum="913C45CEDDE7BCD0" modified="2018-01-31" version="1">MSGRTTALTPPADAGPPVRHPEAPAPGEIIGSHYEYCFGCGGGVAHGLHLETRAGEGVNVTAEFTVREAHQGAPGLAHGGVLATALDETLGSLGWMLRVIAVTGRLETDFLRPVPVGTELHLTAEAVAVHRRKIYCTATGRIGGPDGPVAVHANAMFVEVKIDHFIDNGRKEEIQAVMADPDQVKVARAFEVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9V6</accession>
    <name>A0A2G1X9V6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31725</name>
        <name evidence="3" type="ORF">CYQ11_24780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48024">
        <property type="protein sequence ID" value="PHQ48024"/>
        <property type="gene ID" value="BLA24_31725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15650">
        <property type="protein sequence ID" value="PPT15650"/>
        <property type="gene ID" value="CYQ11_24780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="281" mass="29455" checksum="C364796904565F8B" modified="2018-01-31" version="1">MTILVTGSRGRVARALIGLLHDRGHAVRASSREAGDLGLPAGTEVVRCALDDPSTFPAALEGVSSVFLYAEPAHIDAFVEEAAQAGVQHVVLLSSVAALFPDAASHLIGRPHLLVEQALTEAPFTSTFLRPGSFATNTLGWAHSIKATGSVNLPHPAAHSDAVHEADLAEAALAVLTDSALAGAAYELSGPESLTFEEQIDRLAHVTGRAITVNVVSPEEWKQEVSAFMPAPFADTLLDLWRRTEGVPLPVTGAAAVAKLTGHPARSFTTWAEDHAADFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA19</accession>
    <name>A0A2G1XA19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_31995</name>
        <name evidence="5" type="ORF">CYQ11_25050</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48070">
        <property type="protein sequence ID" value="PHQ48070"/>
        <property type="gene ID" value="BLA24_31995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15696">
        <property type="protein sequence ID" value="PPT15696"/>
        <property type="gene ID" value="CYQ11_25050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="206" mass="22796" checksum="0DC7F12B5D562B5A" modified="2018-01-31" version="1">MPKIVDREARRQEVADAVFRVAARDGLENASLRKVADEAGLAIGSVRHYFTGHGELMTFAMEELARRIEHRVRGHADRILSPGARAGDRRAGMTELLAEFLPLDAARQEEATLWLAFTTAARTRPELRPRLDASHEGMHALLVRVLSEARRAGGLSEDADFDIEALRLAALLDGLTLQAVLRPGDVTPEAMRRVLTRHLDSLRHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA38</accession>
    <name>A0A2G1XA38_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">YfcC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_32110</name>
        <name evidence="8" type="ORF">CYQ11_25170</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48088">
        <property type="protein sequence ID" value="PHQ48088"/>
        <property type="gene ID" value="BLA24_32110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15714">
        <property type="protein sequence ID" value="PPT15714"/>
        <property type="gene ID" value="CYQ11_25170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="508" mass="53156" checksum="0526AE454B98D075" modified="2018-01-31" version="1">MDQQAGAESPERPPEGRRPFVFPSALTVLAAVTVAVWALTFVIPSGTYRRDPDGNPVHGTYHHEAAAGGFVHRLGELFLSPVNGLYGVRDLATGEITPDAVGALYGSAAVFLFVLAIGAFITVVFATGALDRGIERLAHRLRARGALLIAGVMTVFSLLGTVEGFAEETLGFYGLLVPLMLALGYDRMVATGTIILGAGIGVLASTVNPFATGVASSAAGVSLGDGIALRFTMWLVLTAVTIGYVLRYAHRVRTDPDRSLTGFREGDRELAAQAAEPPELTGLQQTVLVLVTLVFAFMIFSVIPWASALTGKADARPYGWELGWSFGQLSALFITAAVLVGLVARLGEQRLSAALVQGAADFIGPALVIVLARGVTVIMTNAKIIDTVLHSMEGVVSGTPAVAFGILVYVVNLPLAFLIPSTSGHATLAMPILAPLADFAGVARSVVVTAWQAASGWMNLWVPTTAVVVGGVSLAKVGYDRYLRFVWPLLAILAVLVCGFVALGAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA66</accession>
    <name>A0A2G1XA66_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32215</name>
        <name evidence="3" type="ORF">CYQ11_25270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48105">
        <property type="protein sequence ID" value="PHQ48105"/>
        <property type="gene ID" value="BLA24_32215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15731">
        <property type="protein sequence ID" value="PPT15731"/>
        <property type="gene ID" value="CYQ11_25270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="136" mass="14145" checksum="810EFF9CA561C80E" modified="2018-01-31" version="1">MTPAQTRQRPPHPLTSAPAGAEAVDLSGPQVCDDMTVEVALAVMAGARVDFLSLCDRDDQVTGSITRTRLVAVRDSSAYTDRLRLRDVLGADGPPAPPAPTTTPGAGHPARCRQPGVPSAVAREHGSALDALTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAB9</accession>
    <name>A0A2G1XAB9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32585</name>
        <name evidence="4" type="ORF">CYQ11_25635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48163">
        <property type="protein sequence ID" value="PHQ48163"/>
        <property type="gene ID" value="BLA24_32585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15789">
        <property type="protein sequence ID" value="PPT15789"/>
        <property type="gene ID" value="CYQ11_25635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="208"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="455" mass="48119" checksum="8BCC45C384CE58FA" modified="2018-01-31" version="1">MADAVTGGSGGAGRVDEVALDEATRFTSELIRIDTTNRGGGDCRERPAAEYVAERLAEAGLEPVLLEKEPGRTNVVARVAGTDPGAEALLVHGHLDVVPADAAEWTVHPFSGEVRDGVVWGRGAVDIKNMNAMVLATVRAWARAGVRPPRDIVLAFTADEEDSAAPGAAHLVADHAPLFEGCTVAVGESGAYTFHGDGGLRIYPVGAGERGTAWLRLTAHGTAGHGSKVNHRNAVARLAAAVTRIGEHRWPVRLTPTVAAALRGLAELHGIEENPEAPGFDVDSLLAKLGKSAGLVAATVRNSANPTVLDAGYKVNVIPGTATAFVDGRTVPGGDEEFRATMDLLTGPDVDWEFHHRDAAVQAPVDGSVFARMREAVERFEPEARVVPFCMSGGTDAKHFSRLGIAGYGFSPLRLPPGWDYQALFHGVDERVPVEGLHFGVRVLDDFMMSAFTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD1</accession>
    <name>A0A2G1XAD1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-ketoglutarate-dependent dioxygenase AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32640</name>
        <name evidence="4" type="ORF">CYQ11_25690</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48172">
        <property type="protein sequence ID" value="PHQ48172"/>
        <property type="gene ID" value="BLA24_32640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15798">
        <property type="protein sequence ID" value="PPT15798"/>
        <property type="gene ID" value="CYQ11_25690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="210" mass="22774" checksum="AB6A27D43BF3DF78" modified="2018-01-31" version="1">MTVQLQGSLFGAADAIGLGRPLAEARRTTLTHGAWLDVLPGWLSGADTLFEVLAGTVPWRAERRHMYDNVVDVPRLLAHYGEADPLPHPVLAEARDALSGHYAAELGEAFRTVGLCFYRDGRDSVAWHGDRIGRGARENTMVAILSVGEPRALVLRPRDGGAPHVRQPLGHGDLVVMGGTCQRTWDHAVPKTSKPVGPRISVQFRPRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD7</accession>
    <name>A0A2G1XAD7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32635</name>
        <name evidence="2" type="ORF">CYQ11_25685</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48171">
        <property type="protein sequence ID" value="PHQ48171"/>
        <property type="gene ID" value="BLA24_32635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15797">
        <property type="protein sequence ID" value="PPT15797"/>
        <property type="gene ID" value="CYQ11_25685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="30502" checksum="E93FC980F4DB28E6" modified="2018-01-31" version="1">MPDESAAAHPDSFSDLGLRADCGDCFGLCCVALPFAASVDFAVNKDAGKPCGNLQEDFRCGIHSRLRERGFKGCTVFDCFGAGQKVSQVTFGGEDWRGSGGTAREMFGVFPVMRQLHELLWYLAEALERPAARPLHRDLRRALDATERLSRESAAALLELDVAAHRQEVNVLLLRTSELVRAKAPAGRKAKDRRGADLMGARLKGADLRGANLRGAYLIAADLTGADLRLTDLIGADLRDASLVGADLSDSLFLTQAQVNAAKGDGRTKLPRSLTRPGHWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAI4</accession>
    <name>A0A2G1XAI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_33020</name>
        <name evidence="14" type="ORF">CYQ11_26070</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48240">
        <property type="protein sequence ID" value="PHQ48240"/>
        <property type="gene ID" value="BLA24_33020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15867">
        <property type="protein sequence ID" value="PPT15867"/>
        <property type="gene ID" value="CYQ11_26070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ48240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="353" mass="36837" checksum="39B88B8C448FA6EE" modified="2018-01-31" version="1">MPVLTRLIPSPVVVDIRAGALDDLASVLADQRISSSGKLAIAISGGSGAVLRERLAPALPGATWYEVGGGTLDDAIKLGDAMKKGHYDAVVGLGGGKIIDCAKYAAARVGLPLVAVATNLSHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIREAPVRFVRSGIGDAISNISSVADWELAHRETGEAIDGLAAAMARQAGEAVLRHPGGVGDDSFLQVLAEGLVLTGISMSVAGDSRPASGACHEINHAFDLLYPKRAASHGEQCGLGAAFAMHLRGAREESALMVEVLRRHGLPVLPGEIGFTDEEFVKAVEFAPQTRPGRYTILEHLALSTDQIRDAYADYAKTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAT6</accession>
    <name>A0A2G1XAT6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_31190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48336">
        <property type="protein sequence ID" value="PHQ48336"/>
        <property type="gene ID" value="BLA24_31190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="239" mass="24907" checksum="2B0479A7D19BDAE3" modified="2018-01-31" version="1">MGAGQRLLPGMPPEAAVGALSRSLAAGETTVMIADVEWAGFGARFTGLRPSPLLSELLGGLPAAAVTPVEPAEELAARLRSMPPAEQERTVLESVRAQVAAVLGHAKPASVDPARRFLEIGFDSLTAVELRNRLAAATGLRFAASVIFDYPTPAALAGHIRAELAGDERTPPALDELTRLEAALSALSPSDAAGAEVTARLQSLLSRWTDSGSNDVDVEVDSATDDEIFDLIGKEFGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAW1</accession>
    <name>A0A2G1XAW1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32620</name>
        <name evidence="4" type="ORF">CYQ11_25670</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48377">
        <property type="protein sequence ID" value="PHQ48377"/>
        <property type="gene ID" value="BLA24_32620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16803">
        <property type="protein sequence ID" value="PPT16803"/>
        <property type="gene ID" value="CYQ11_25670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="76" mass="8428" checksum="5B3969441B44CC48" modified="2018-01-31" version="1">MALTLEQIRADVADVLGEDPADIPDDENLVDYGLDSVRIMSLLERWRRDHGVQAGFVELAEKPAIEQWAPLLGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX5</accession>
    <accession>A0A346M2I8</accession>
    <name>A0A2G1XAX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">BcmE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bcmE</name>
        <name evidence="7" type="ORF">BLA24_33480</name>
        <name evidence="8" type="ORF">CYQ11_26530</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <title>Biosynthesis of biocyclomycin.</title>
            <authorList>
                <person name="Meng S."/>
                <person name="Pan H.-X."/>
                <person name="Tang G.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MG018995">
        <property type="protein sequence ID" value="AXQ04976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XAX5"/>
    <dbReference type="EnsemblBacteria" id="PHQ48394">
        <property type="protein sequence ID" value="PHQ48394"/>
        <property type="gene ID" value="BLA24_33480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16816">
        <property type="protein sequence ID" value="PPT16816"/>
        <property type="gene ID" value="CYQ11_26530"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="173"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AXQ04976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="314" mass="35034" checksum="114899C403AB38AC" modified="2018-01-31" version="1">MASPDSATLREPVVLPPMPGEHEARAAYPPIGLERSRVTGGRLVFDRDEGFDRALAQGFFLVRIPEGTDPAAGDRFAAHFHEERAGGDPLDAYRGYRHVRVPGDYQGYFDREHDQWENFYVERDNWDVLPSEVARVGRGMAGLGVTILRGVLEHLRLPREHWARVTGGLTEDRGHQMLAFNHFRSHKGVRGSKFHRDSGWVTVLRSVDPGLLALVDGRLWAVDPEPGHFIVNFGSSLEVLTERLDRPVRANVHGVVSTERAPGQPDRTSYVTFLDSDLTGTVYRFENGTPRPLQSVAEFAGQEVGRTYDDSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBG2</accession>
    <name>A0A2G1XBG2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29825</name>
        <name evidence="3" type="ORF">CYQ11_05650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48550">
        <property type="protein sequence ID" value="PHQ48550"/>
        <property type="gene ID" value="BLA24_29825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12449">
        <property type="protein sequence ID" value="PPT12449"/>
        <property type="gene ID" value="CYQ11_05650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304549" evidence="1">
        <location>
            <begin position="26"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="426" mass="45564" checksum="CC2B1BCEABC917C4" modified="2018-01-31" version="1">MRTKSAIVAGLAAVAALAASVPATAATPASAALTARPNCPQLDKNTPWFGDNRAKLQKMIDERGTCSGKRGGARPVAAFDWDNTVVKNDITDATLAWSLKHDKILRPKHWSDTSKWLTPAADRALTKACGTSVPVGHPLPTSKNTACTDEIFEIREKSQTMSGEAAFAGDWNHRRTVPAYAWIPQLFAGHTPAALTSFAKRARAEQLAAPVGAKQTVGTHTIAGYVRYYDQQKDLIRTLKAAGFDVYIISASSEPIAEAWSSGVGLDRKHTVGIRSIVEHGRLTTGVKGCGDVADGAGEAIPYMDGKRCVINQEIFKIKGAKAWQQQDFSHRIALGAGDADTDVTFVNDATGAHVAVNRNKAELMCRAYDDADGRWVANPMFIEPMPRKSGTYPCSTTGATAADGSKVPVKRADGSVIADQVDRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBI0</accession>
    <name>A0A2G1XBI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_28965</name>
        <name evidence="7" type="ORF">CYQ11_06510</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48578">
        <property type="protein sequence ID" value="PHQ48578"/>
        <property type="gene ID" value="BLA24_28965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12589">
        <property type="protein sequence ID" value="PPT12589"/>
        <property type="gene ID" value="CYQ11_06510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="30235" checksum="02DFC75ECFF30FB0" modified="2018-01-31" version="1">MSRLTAESVTLAYDGRVIAEDLSVAVPDHSFTVIVGPNACGKSTLLRALSRMLKPRAGSVLLDGQAIGSYPARKVARTLGLLPQSSVAPDGITVADLVARGRHPHQGLLRQWSPEDERIVEESMAATGVAALADRYVDELSGGQRQRVWIAMALAQRTPLLLLDEPTTYLDIQHQIEVLDLCADLHETQGRTLVAVLHDLNHAARYATHLIAMRDGRVVAEGPPSEVVTAGLVERVFGLRCQVIDDPQTGTPLVVPAARTARTPREAAPTGPSAAAAGPAAAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBJ6</accession>
    <name>A0A2G1XBJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_29320</name>
        <name evidence="6" type="ORF">CYQ11_06155</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48592">
        <property type="protein sequence ID" value="PHQ48592"/>
        <property type="gene ID" value="BLA24_29320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12536">
        <property type="protein sequence ID" value="PPT12536"/>
        <property type="gene ID" value="CYQ11_06155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="320" mass="33794" checksum="8D2D150FE84E8581" modified="2018-01-31" version="1">MTTYAVLSEGLRKRFREVQALDGLDLAVPPGTVCGLLGPNGAGKSTAVRLLTTLLTPDSGTARVAGHDVVRAPEAVRRAIGVTGQSTSVDMDLTGRENLRLFGRLHRLSPAAARARADELLERFGLDGAADRSAGGYSGGTRRRLDLAAALITRPEVLFLDEPTTGLDPASREGIWQTVRELADHGTTVLLTTQYLEEADRLADDIVLIDRGRATEHGTPAALKARIGARAEVVVADDAALPGAAVVLGALTGARPEVFPERRAAAAAVTDPAVTLPFLVRELDAAGVRVVDATLRQPTLDEAFLRLTAPDRAETEEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBL9</accession>
    <name>A0A2G1XBL9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">whiA</name>
        <name evidence="8" type="ORF">BLA24_28360</name>
        <name evidence="9" type="ORF">CYQ11_07110</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48633">
        <property type="protein sequence ID" value="PHQ48633"/>
        <property type="gene ID" value="BLA24_28360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12688">
        <property type="protein sequence ID" value="PPT12688"/>
        <property type="gene ID" value="CYQ11_07110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="335" mass="35665" checksum="35637454B9E4EFA5" modified="2018-01-31" version="1">MAMTAAVKDEISRLPVTRTCCRKAEVSAILRFAGGLHLVSGRIVIEAELDTGIAARRLRKDILEIFGHASDLVVMAPGGLRRGSRYVVRVVAGGDQLARQTGLVDGRGRPIRGLPPQVVSGATCDAEAAWRGAFLAHGSLTEPGRSSSLEVTCPGPEAALALVGAARRLQIAAKAREVRGVDRVVVRDGDAIGALLTRLGAHESVLAWEERRMRREVRATANRLANFDDANLRRSARAAVAAGARVQRALEILGEEVPEHLAAAGRLRMEHKQASLEELGALADPPLTKDAVAGRIRRLLAMADKRAQDLGIPGTESTLSDLSDLTEEMAEGMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBM2</accession>
    <name>A0A2G1XBM2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1844 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29855</name>
        <name evidence="3" type="ORF">CYQ11_05620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48605">
        <property type="protein sequence ID" value="PHQ48605"/>
        <property type="gene ID" value="BLA24_29855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12444">
        <property type="protein sequence ID" value="PPT12444"/>
        <property type="gene ID" value="CYQ11_05620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="129" mass="13348" checksum="07169AE2D5BB8E01" modified="2018-01-31" version="1">MSDATPSNDSSADTPGEGTPDFDTMTRDIADVPAVEVITTVAVHLMSAAAVNLGLAEEGEQHKDLDEARKLITALAGLVTASATEVSNFHAAPLRDGLKSLQLAFREASVVPDEPGQGPGEKFTGPVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBQ7</accession>
    <name>A0A2G1XBQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-6-phosphate dehydrogenase assembly protein OpcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">opcA</name>
        <name evidence="2" type="ORF">BLA24_28405</name>
        <name evidence="3" type="ORF">CYQ11_07065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48641">
        <property type="protein sequence ID" value="PHQ48641"/>
        <property type="gene ID" value="BLA24_28405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12680">
        <property type="protein sequence ID" value="PPT12680"/>
        <property type="gene ID" value="CYQ11_07065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="357" mass="37779" checksum="52F42D33451AD72D" modified="2018-01-31" version="1">MKMDLTDTTASKINQALVEGRRAIGTPAIGMVLTLVIVTDEEHAYDALKAANEASREHPSRKLVVIKRVSRSPRDRAQARLDAEVRVGTSAGTGETVVLRLYGEVIDHAQSVVLPLLLPDAPVVVWWPVASPPNPEKDPLGALGQRRVTDTYAAEDPVAELSARAANYTPGDTDLAWTRITPWRSMLAAALDQQPGIEVLSAEVEGEAYNPSGELLAMWLADRLGVTARRTVSDGPGLTAVRLETKSGVVTLDRPDGSLATLAMRGQPDRAVALKRRDTAELLAEELRRLDPDLIYESALKYGVERLGEPVSAAPAAAGGSAQESPAGDAEAAAPAETPEGKAAPAKKSSGKKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBU5</accession>
    <name>A0A2G1XBU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28720</name>
        <name evidence="4" type="ORF">CYQ11_06745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48692">
        <property type="protein sequence ID" value="PHQ48692"/>
        <property type="gene ID" value="BLA24_28720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12627">
        <property type="protein sequence ID" value="PPT12627"/>
        <property type="gene ID" value="CYQ11_06745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="228"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="468" mass="49753" checksum="EBA019B0CEF79B0E" modified="2018-01-31" version="1">MSPRTNKPHEIVERALELSRADGCTVIAQEQSTANLRWAGNALTTNGVTRGRTLTVVATVDGKEGTASGSVTRSAVTADDLEPLVRAAEAAAREAGPAEDAQPLVTGVPHAADFTGAPAETSPAVFDAFAPALGEAFARARAQGRELYGFARHETESSYLGTSTGLRLRHDQPTGTLEINAKTPDRAHSAWAGRATRDFLDVDPLTMEAELAERLAWGSRKKLELPAGRYETLLPPTAVADLLVYQQWSASARDAAEGRTVFSKAGGGTRVGEKLSELPLTLRSDPHAPGLECAPFVLTGSSGDDASVFDNGLPIAATDWIRDGVLERLVTTRHSAGLTGLPLSPYTDNLVLDAGGTRSLTEMVAAAGHDGPALLLTCLWYIREVDPASLLLTGLTRDGVYLVDKGEVVGEVNNFRFNESPVDLLSRAVEAGRTEPTLPREWGDYFTRAAMPALRVPDFNMSSVSKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC30</accession>
    <name>A0A2G1XC30_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">BLA24_27215</name>
        <name evidence="10" type="ORF">CYQ11_18440</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48770">
        <property type="protein sequence ID" value="PHQ48770"/>
        <property type="gene ID" value="BLA24_27215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14582">
        <property type="protein sequence ID" value="PPT14582"/>
        <property type="gene ID" value="CYQ11_18440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="123"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="29982" checksum="B090A435FC30ADF9" modified="2018-01-31" version="1">MTAKILDGKATAAAIKSELTVRVEALKAKGVTPGLGTLLVGDDPGSKWYVAGKHRDCAEVGIGSIQRELPATATQEEIEAVVRELNENPDCTGYIVQLPLPKGIDTNRVLELMDPAKDADGLHPMSLGRLVLNETGPLPCTPNGIIELLRRHDVELNGAHVVVVGRGITVGRSIGLLLTRRTENATVTLCHTGTRDLSEQLRRADIIVAAAGVGHLIKPEDVKPGAAVLDVGVSRDGEGKIMGDVDPAVAGVAGWVSPNPGGVGPMTRALLLVNVVEAAERAAGGGDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCN6</accession>
    <name>A0A2G1XCN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Insulinase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_22880</name>
        <name evidence="6" type="ORF">CYQ11_23195</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48955">
        <property type="protein sequence ID" value="PHQ48955"/>
        <property type="gene ID" value="BLA24_22880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15400">
        <property type="protein sequence ID" value="PPT15400"/>
        <property type="gene ID" value="CYQ11_23195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="199"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="49390" checksum="C65B848FBEAD4E1A" modified="2018-01-31" version="1">MTSRSTRKTARTSSEGRAVARTQTLLKGENGIGTVRRTTLPGGLRIVTETLPSVRSATFGIWANVGSRDETPTLNGATHYLEHLLFKGTAKRSALDISAALDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSLIDAADVDAERGVILEEIAMTEDDPGDCVHDLFAHTMLGDTPLGRPVLGTVDTINALTRDQIARFYKKHYDPTHLVVAAAGNVDHAKVVRQVRAAFEKAGALGRADAVPVGPRSGTKTIRTAGRVELLGRKTEQAHVVLGMPGLARTDERRWALGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSGFADCGLFGVYAGCRPNQVHDVLRICRDELDRVAAEGLTDEEIGRAIGQLSGSTVLGLEDTGALMNRIGKSELCWGDQMSVSDMLERISAVTPDEIREVARDVLGQRPSLSVIGPLKDKQAARLHEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCS2</accession>
    <name>A0A2G1XCS2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22905</name>
        <name evidence="3" type="ORF">CYQ11_23170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48959">
        <property type="protein sequence ID" value="PHQ48959"/>
        <property type="gene ID" value="BLA24_22905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15396">
        <property type="protein sequence ID" value="PPT15396"/>
        <property type="gene ID" value="CYQ11_23170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="15331" checksum="9C04BF35D7F03FB8" modified="2018-01-31" version="1">MTASELSPEWSRLFRTEGQDTSIAVRDGARMSLASAGGGQGGRAGSDTHKASGGPWTAAGGVAGELRTSTQSAITKLDSSHEGLESGTAGFASTAALKGIRSGWKSRLEAVRDHFDKLAPNLAQAGKEFDAHEVKTEGTFAPAGRKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC8</accession>
    <name>A0A2G1XDC8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24545</name>
        <name evidence="5" type="ORF">CYQ11_21525</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49236">
        <property type="protein sequence ID" value="PHQ49236"/>
        <property type="gene ID" value="BLA24_24545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15112">
        <property type="protein sequence ID" value="PPT15112"/>
        <property type="gene ID" value="CYQ11_21525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304588" evidence="3">
        <location>
            <begin position="33"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="24971" checksum="972EED5B9FDB976B" modified="2018-01-31" version="1">MSPSRRLVRSVRTVALAAGAAVLAVPTVPAGAAPAAPPGRPVSALLTQLQSLYRKAEEAGEAYAATREKLKKQRAVVDRLGEELAGARVALNAGRVDAGRLARAQYRDGGGAAAAPWLRFLFSSDARQAMDTRHQIDRAADSRAAVIGRLSQDARRTATLASRSRDALNVQQTLTAEQRKQKDAVRKRLGAVEKLLASLSPGQLAELRRVEGGSGGGAAAGRLRLRLPGARPAHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDD0</accession>
    <name>A0A2G1XDD0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24595</name>
        <name evidence="2" type="ORF">CYQ11_21475</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49244">
        <property type="protein sequence ID" value="PHQ49244"/>
        <property type="gene ID" value="BLA24_24595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15104">
        <property type="protein sequence ID" value="PPT15104"/>
        <property type="gene ID" value="CYQ11_21475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="107" mass="11596" checksum="E0B4D471498801C5" modified="2018-01-31" version="1">MTYRNGTYVMDTRENRIAQVIGETGTRVQVQRPGGGLTWEVPASALRLATRDERNAAGLRPYQSGCAECAVLEAARTSALDGEKPAAAAAARTHWIVAHSTQLRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDU0</accession>
    <name>A0A2G1XDU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_25500</name>
        <name evidence="7" type="ORF">CYQ11_20575</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49403">
        <property type="protein sequence ID" value="PHQ49403"/>
        <property type="gene ID" value="BLA24_25500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14947">
        <property type="protein sequence ID" value="PPT14947"/>
        <property type="gene ID" value="CYQ11_20575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="351" mass="38247" checksum="E8718E3041D256DB" modified="2018-01-31" version="1">MTEDILVAEGLTKHFPVMGGFPVRRRVGAVQAVDGVDLTVRTGESFGLVGESGCGKSTTGRLLTRLLEPTAGRVLYRGQDITRAGRRQLASIRSEIQMIFQDPYASLNPRQTVGRIITGPMEINGIAPPGGREARARELLEVVGLSPEHYNRFPHEFSGGQRQRVGVARALALEPKVIVADEPVSALDVSIQAQVVNLLRRVQRELGIAFLFIAHDLAVVRHFSQRVAVMYLGRIVEVGGRQDIYEHPRHPYTHALLSAVPQPADATGTARERIRLAGDVPSPVLPPSGCRFRTRCWKAQEVCATQVPPLVRAEGSAEGHLAACHFPEPPTVERDTEVILDPALRSAEGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE01</accession>
    <name>A0A2G1XE01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25900</name>
        <name evidence="2" type="ORF">CYQ11_20170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49474">
        <property type="protein sequence ID" value="PHQ49474"/>
        <property type="gene ID" value="BLA24_25900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14876">
        <property type="protein sequence ID" value="PPT14876"/>
        <property type="gene ID" value="CYQ11_20170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18460" checksum="74F4BF5ED31C2795" modified="2018-01-31" version="1">MAGIPDHIKALAELSPVEDLLLAILRKGLPGIRVKSLIDRHEQFPLVLVRRDPTFGQWAADTRFTDAARVVVNCFAEDPDGDSDAAILSEAVRVVLRDSWLNHEVVPGRGHITRVDMNSSPRRASDWATATGPVQYADLPTGVWRYESVYDIQIRKPRTRPFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEB5</accession>
    <name>A0A2G1XEB5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_26290</name>
        <name evidence="8" type="ORF">CYQ11_19350</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49541">
        <property type="protein sequence ID" value="PHQ49541"/>
        <property type="gene ID" value="BLA24_26290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14739">
        <property type="protein sequence ID" value="PPT14739"/>
        <property type="gene ID" value="CYQ11_19350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="468" mass="47725" checksum="BB6EA3475D50A91F" modified="2018-01-31" version="1">MTTTTLADPPVLSARRRWTVLAVCALSMFLVGLDTTIVNVGLPEIGRGLDVGTRGLEWVVDAYTVVLASLLTASGALADRFGRRRVFRCGLVVFGVASLACALAPSLGFLVAARAAQGVGASMLSPVALAIVVNAMPDPRERARAIGVWASVFGLSMAAGPVTGGALIAAFGWRSVFWVNAPVIVAALLLVAVFVPESHGQRARRLDLPGQALLTLALCVSVGVLIEGPRIGWASPPALTGYAVIGAATAGFARVELRRSEPLMDLGLFRRPLFTTSTLGAVAVFVALNVTLLLNTFYLQHARGWTAFETGTATLPMALGATLCAPWSGSLVGRLGPRRPLVLAGGFTAAGGLCMVTVGQGTSVLLLLLAYLLIGIGFGFANAPITNTAVGGLPPSRAGVAGAITSTARQVGSAVGIAVAGGLVADVGPAGLAHASRPGWLLVTACGLFLFVVARAARAATPPARKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEQ4</accession>
    <name>A0A2G1XEQ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ORF">BLA24_24430</name>
        <name evidence="14" type="ORF">CYQ11_21640</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49717">
        <property type="protein sequence ID" value="PHQ49717"/>
        <property type="gene ID" value="BLA24_24430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16710">
        <property type="protein sequence ID" value="PPT16710"/>
        <property type="gene ID" value="CYQ11_21640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ49717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT16710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="264" mass="29258" checksum="495DE7FBF2AA782A" modified="2018-01-31" version="1">MLAFETDCHIFDGCGFPAPGLHSFLFEPIFSIGGYDFNKPMLLAVLTTVIVIGFFWAAFGKAKVVPGKLQMVGEAGYDFVRRGIVYEALGKKQGEKYVPFMVSLFFFVWIMNLWSIIPVAQFPVTSIIAFPAALALIVYVMWMTLTFKKHGFVGGLKNITGYDKSLGGVLPLAVVLEFFSNVLIRPFTHAVRLFANMFAGHLLILMFTVASWYLLNGIGIAYAGVSFVMTIVMTGFELFIQAVQAYVFVLLATNYIQGALAEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEU4</accession>
    <name>A0A2G1XEU4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">BLA24_23220</name>
        <name evidence="7" type="ORF">CYQ11_22855</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49689">
        <property type="protein sequence ID" value="PHQ49689"/>
        <property type="gene ID" value="BLA24_23220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15343">
        <property type="protein sequence ID" value="PPT15343"/>
        <property type="gene ID" value="CYQ11_22855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="185" mass="20927" checksum="17A06DC1FDEF4C99" modified="2018-01-31" version="1">MIEEILLESEEKMEKAVVVAKEDFAAIRTGRAHPAMFNKIVADYYGALTPINQLASFSVPEPRMAVVTPFDKTALRNIEQAIRDSDLGVNPSNDGNIIRVTFPELTEQRRREYVKVAKTKAEDAKVSIRSVRRKAKDALDKLVKDKETGEDEVRRAEKELDDTTAKYVAQVDELLKHKEAELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEX1</accession>
    <name>A0A2G1XEX1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19205</name>
        <name evidence="5" type="ORF">CYQ11_11595</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49780">
        <property type="protein sequence ID" value="PHQ49780"/>
        <property type="gene ID" value="BLA24_19205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13444">
        <property type="protein sequence ID" value="PPT13444"/>
        <property type="gene ID" value="CYQ11_11595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="3">
        <location>
            <begin position="234"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="620" mass="65444" checksum="299F39E3C8DF24A8" modified="2018-01-31" version="1">MAATRPEATVTVRGRGTGRRRTAGLVALAACGALLAGCASMPGSGEVSSVDSSQRADADAQVRVYGVPPRKAEQPMELVTGFLEATTSDDPDYETARMYLAKSVKRQWDPSARTTVLSATPQVKVERIGGDREQGSYTVTLTGRQVATVDAKHAYTPEEQDFKTQLHMAREDGEWRIDQLNAGLVIGVSDFQRIYRSVNKYYFAERGSGEGGSGKARPGLVADPVYLRKRIDTVTTTVRALLDGPTGWLDPVAVTSFPSGTRLEDRRLSLDDSNALKVRLNDRVAGASQEQCLRMAAQLLYTVQESAKVTDVTLQRKDGSRLCVLGKEEAKSYASEQTSGRPGRQYFVDGQHRMVALTDGDDEAHRVPGPLGADGGVPLRSVAVERGDGHAAGVSANGQSLYVTAMRAGAALGEARLAVHGGTAPKTGLTAPSWDGLGDLWVADQDPDRPRLLRLPGGTGAPEEVPVAGLDGRVTGLRVAADGVRVALLVTKGDHTTLKLGRVERHASAGRTTLSVQELRSVAPRLEDVSAVSWAGASRLLVAGSEQGGLQQLQYVETDGSQGNGAGLPGITGVRGVAASENPAKSQALVAEGEGGIVRLLPDTNWKLVGKEGSAPVYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEY9</accession>
    <name>A0A2G1XEY9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22750</name>
        <name evidence="4" type="ORF">CYQ11_14170</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000152">
        <property type="protein sequence ID" value="PHQ49775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49775">
        <property type="protein sequence ID" value="PHQ49775"/>
        <property type="gene ID" value="BLA24_22750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13882">
        <property type="protein sequence ID" value="PPT13882"/>
        <property type="gene ID" value="CYQ11_14170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="23848" checksum="BDBF12A8A3873B9F" modified="2018-01-31" version="1">MNTAENSSQNTAENSAENAEAGAESTAPSAPRTLVGDIAPDAALLVIDVQKAWHDPSFPPRDNPAAEDNMAQLIDAWQETGRPVVFVRHDSPKADSPLRPGQEGNDFQPFVEQRRGKGTGPELLLTKTVNSAFIGTPDLRDWLDGAGIRQIVVVGVMTNWCVETTARMGGNLGYDVVVPIDATHTFDAVGPDGHSLTADELARATATNLHAGGFAKVVRTADLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF91</accession>
    <name>A0A2G1XF91_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rdgB</name>
        <name evidence="8" type="ORF">BLA24_19720</name>
        <name evidence="9" type="ORF">CYQ11_11075</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49871">
        <property type="protein sequence ID" value="PHQ49871"/>
        <property type="gene ID" value="BLA24_19720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13353">
        <property type="protein sequence ID" value="PPT13353"/>
        <property type="gene ID" value="CYQ11_11075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="21031" checksum="51F82296B22FE5A7" modified="2018-01-31" version="1">MKRLILATRNANKVTELRAILQTAGLDVELVGAEAYPDVPDVKETGVTFAENALLKAHALARATGHPAVADDSGLCVDVLNGAPGIFSARWAGKHGDDKANLDLLLAQLSDIDDAHRSAHFACAAALALPDGTERVVEGRLEGTLRHAPTGTGGFGYDPILQPLGDSRTCAELTAEEKNAISHRGKAFRGLVPVVRELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN5</accession>
    <name>A0A2G1XFN5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20815</name>
        <name evidence="4" type="ORF">CYQ11_09965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50050">
        <property type="protein sequence ID" value="PHQ50050"/>
        <property type="gene ID" value="BLA24_20815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13171">
        <property type="protein sequence ID" value="PPT13171"/>
        <property type="gene ID" value="CYQ11_09965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="324" mass="33031" checksum="AA9AC5BE8F368F46" modified="2018-01-31" version="1">MSYHQPGPYGQPPQPPQGPNPYGQGGAPGQPGYGYPQQPQAPYGAPPPPPGAWGQPQPPGPYGQQPMPGMPGQYPPPVPPQGGGKGKAIGITIGALVVVGAVVGGFVFLKGGKDDDGGGGSGSAKAVQPYTIELPQALLDGKYTKVTAPGGQSGDDSKSLADDAKAKEMGIEGGTGVSGSYTSAEKQKLMVVGAYGQLADPKKTVDAMIARMDESEKKNQETMKGLQIQTVTAWTEFTPAGFDGAVMKCETKKSTYTMGAVSSTGDLSVCIWGDSSAMGIVRQVVSKTSGGIAGGVTSATGEGMSAKELSDATVKVRNEVRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS0</accession>
    <name>A0A2G1XFS0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21045</name>
        <name evidence="4" type="ORF">CYQ11_09740</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50084">
        <property type="protein sequence ID" value="PHQ50084"/>
        <property type="gene ID" value="BLA24_21045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13135">
        <property type="protein sequence ID" value="PPT13135"/>
        <property type="gene ID" value="CYQ11_09740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304616" evidence="2">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="27212" checksum="BA3AA47BAE31CADD" modified="2018-01-31" version="1">MVVAAVTIALIFTILVVCAVIATVKAVRTVKRGVDRTVTQARRTVEDTRLKARQYTQPGPAGELAQLRLSLRASMRATQEVLRVSVAEDSSLSESLALFERLSAHGRELDEDLRKLEEEPDKARVATCLPELRERTERVRHAADSLRWAAQDRARQFAEDDLSLLSEQIRMETGALRHWEDDDGAAVPPASGAAGKPEEPRTGRTGAGAAAEGGTGGPASEEPARPALDGRNGSWQAGYPWQKAKRPEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS6</accession>
    <name>A0A2G1XFS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21000</name>
        <name evidence="5" type="ORF">CYQ11_09785</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50077">
        <property type="protein sequence ID" value="PHQ50077"/>
        <property type="gene ID" value="BLA24_21000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13142">
        <property type="protein sequence ID" value="PPT13142"/>
        <property type="gene ID" value="CYQ11_09785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="441"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="529" mass="55623" checksum="1D9B2AF489D66E40" modified="2018-01-31" version="1">MNDRQDPYAHDPYARPQVYGYDAYGQPVYRPDAPDLAYDAYGRPLQQAQPQQQTQPYEQYDAYGQSPQPQQQTQQEWIPRQAGPPVHEEPPRQAAPHEQIPEPRAASDQAAQDPAPEAYRTEQFSFIEEPDEDSEDVIDWLKFTESRTERRDERKRKGRNRVIALAVVLVLAVGGGVGWFLLSGGDAGKGAAKAGAGQKRDVIVVHLRETRGGGSSTALLVDNETTKKGTTVLLPNTLAVAKDGGAATTLGKSVQEAGTGDTRDALNTLLGADIKGSWRLDTPYLENLVELVGGISVDTDVTVPGAKAGDRPLVTQGKGQTLGGQAAVAYATHRAPGEAPDKQLTRFGQVMQGVLRKLSTDPATATTTVESLAQIPDPSLSVPQLGASLAHLAAKAKQGSYDTSVLPVRADGTLGEQAADTMVKDVLGGTVKNTDKNAPPRVSVKNATGGAAAAGAAQVTLVNGGYTYVDAGSASSAEAASAVVYADDARAAEAKEVAKTLGLPERAVKKGQAAGNADVTVVLGKDYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFZ2</accession>
    <name>A0A2G1XFZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21530</name>
        <name evidence="2" type="ORF">CYQ11_09255</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50160">
        <property type="protein sequence ID" value="PHQ50160"/>
        <property type="gene ID" value="BLA24_21530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13056">
        <property type="protein sequence ID" value="PPT13056"/>
        <property type="gene ID" value="CYQ11_09255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="22168" checksum="5F3B41E834ED7C4E" modified="2018-01-31" version="1">MSELLLVRHGETEWSRDGRHTSWTDKPLTARGEREAASLRPALAARDVGLVLVSPMTRAARTAELAGLVAARTEPDLREWDYGGYEGVTTAEIRRTRPGWSLFEDGVVPGPEGHPGETPEQVGARADRVLARIEGRPREPGGDVVLVAHAHFLRVLTARRLGLPPSAGALFRLDTGTVSALGTEHGRPVLVAWNGRVGTGGDPAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG52</accession>
    <name>A0A2G1XG52_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21830</name>
        <name evidence="6" type="ORF">CYQ11_08955</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50212">
        <property type="protein sequence ID" value="PHQ50212"/>
        <property type="gene ID" value="BLA24_21830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13004">
        <property type="protein sequence ID" value="PPT13004"/>
        <property type="gene ID" value="CYQ11_08955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="155" mass="16690" checksum="D58EF5811DF4F53B" modified="2018-01-31" version="1">MLIRMSTAAQSPRSTPLHSVSVAGAVVRDDGRVLAIRRADNGNWELPGGVLEIEESPEAGARREVLEETGIEVSVDRLTGVYKNMTRGIVALVFRCRPVGGSERTSDESAAVSWLTPEEVTAAMAEAYAVRLLDALSDDAPHVRVHDGRRLMPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG64</accession>
    <name>A0A2G1XG64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21855</name>
        <name evidence="2" type="ORF">CYQ11_08930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50217">
        <property type="protein sequence ID" value="PHQ50217"/>
        <property type="gene ID" value="BLA24_21855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12999">
        <property type="protein sequence ID" value="PPT12999"/>
        <property type="gene ID" value="CYQ11_08930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="210" mass="23911" checksum="667BD5B4ACA08E6C" modified="2018-01-31" version="1">MLLWINGPFGAGKTQTAHEIRRRLPGSVVCDPEEVGFGLHRMTPPRLRGDFQDLTAWRQGVYEVLDLVLTRHEGVVIAPMTITEPAYFRETVGRLRERGHGVRHFALLARRETVLRRLGERNPVHAVQRAMGRNAPPRGESFAVARLDVCLERLREEEFADHVWTDRLTVPQVADHIAESAGLRLAPDRDGALRGRLRRAWTGARHIRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG68</accession>
    <name>A0A2G1XG68_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21330</name>
        <name evidence="5" type="ORF">CYQ11_09455</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50129">
        <property type="protein sequence ID" value="PHQ50129"/>
        <property type="gene ID" value="BLA24_21330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13090">
        <property type="protein sequence ID" value="PPT13090"/>
        <property type="gene ID" value="CYQ11_09455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="32037" checksum="68FD96A8A9FD021D" modified="2018-01-31" version="1">MARRGILGRSRREYRTPEPHPSGARPPKIPGELVPEHVAIVMDGNGRWAKERGLPRTEGHKVGAERVLDVLQGGIEMGVGAISLYAFSTENWRRSPDEVRFLMNFNRDFIRKTRDQLDELGIRVRWVGRMPKLWKSVAKELQVAQEQTKDNDRLTLYFCMNYGGRAEIADAAQAMAEDVKAGRLDPSKVSEKTLQKYMYYPDMPDVDLFLRPSGEQRTSNYLIWQSAYAEMVFQDVLWPDFDRRDLWRACLEYAQRDRRFGGALPNEDQLVKEPSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH21</accession>
    <name>A0A2G1XH21_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">BLA24_17070</name>
        <name evidence="10" type="ORF">CYQ11_16205</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50533">
        <property type="protein sequence ID" value="PHQ50533"/>
        <property type="gene ID" value="BLA24_17070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14213">
        <property type="protein sequence ID" value="PPT14213"/>
        <property type="gene ID" value="CYQ11_16205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="199" mass="21768" checksum="7FD0D9A828595F0A" modified="2018-01-31" version="1">MYEGVVQDLIDELGRLPGVGPKSAQRIAFHILQAEPADVRRLAHALTEVKAKVRFCAVCGNVAQEERCRVCQDPRRDLAVICVVEEPKDVVAIERTREFRGRYHVLGGAISPIEGVGPDDLRIRELLARLADGSVTELILATDPNLEGEATATYLARMVKPMGLKVTRLASGLPVGGDLEYADEVTLGRAFEGRRLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH67</accession>
    <name>A0A2G1XH67_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BLA24_17060</name>
        <name evidence="21" type="ORF">CYQ11_16215</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50531">
        <property type="protein sequence ID" value="PHQ50531"/>
        <property type="gene ID" value="BLA24_17060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14215">
        <property type="protein sequence ID" value="PPT14215"/>
        <property type="gene ID" value="CYQ11_16215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="268"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="350"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PHQ50531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PPT14215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="423" mass="44728" checksum="C3E8C71FF7444184" modified="2018-01-31" version="1">MGLVVQKYGGSSVADAEGIKRVAKRVVEAKKNGHQVVVVVSAMGDTTDELIDLAAQVSPIPAGREFDMLLTAGERISMALLAMAIKNLGHEAQSFTGSQAGVITDSVHNKARIIDVTPGRIQQSVDAGNIAIVAGFQGVSQDKKDITTLGRGGSDTTAVALAAALDAEVCEIYTDVDGVFTADPRVVKKARKIDWISFEDMLELASSGSKVLLHRCVEYARRYNIPIHVRSSFSGLKGTWVSNEPQGDQPMEQAIISGVAHDTSEAKVTVVGVPDKPGEAATIFRAIADADINIDMVVQNVSAASTGLTDISFTLPKTEGHKAIEALEKTKTRVGFDSLRYDDQIAKISLVGAGMKTNPGVTATFFEALSNAGVNIELISTSEIRISVVTRADDVNEAVRAVHTAFGLDSESDEAVVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH89</accession>
    <name>A0A2G1XH89_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase P family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_17495</name>
        <name evidence="9" type="ORF">CYQ11_15780</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50596">
        <property type="protein sequence ID" value="PHQ50596"/>
        <property type="gene ID" value="BLA24_17495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14149">
        <property type="protein sequence ID" value="PPT14149"/>
        <property type="gene ID" value="CYQ11_15780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="7">
        <location>
            <begin position="61"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="496" mass="54559" checksum="A40C5854A5A8D1E6" modified="2018-01-31" version="1">MESGPVRGGKPVTEQPAPENPEGDEPIKQRKNGLYPAVSDELADNMKSGWADTELRDLQPIPQAAETARRRAELSARFPGERLVVPAGNLRTRSNDTEYAFRASTEYVYLTGDQTEDGVLVLEPAGAEGHEATVYLLPRSNRENGEFWLDGQGELWVGRRHSLGEAEQLLGVPARDVRELADALREATGPVRVVRGHDAGIESALTDKVTAERDEELRVFISEQRLVKDAFEIGELQKAVDSTVRGFEDVVKVLDKAEATSERYIEGTFFLRARVEGNDIGYGSICAAGPHATTLHWVRNDGPVRSGELLLLDAGVETHTLYTADVTRTLPVNGTYTELQRKIYDAVYEAQEAGIAAVRPGAKYRDFHDAAQRVLAERLVEWGLVEGPVERVLELGLQRRWTLHGTGHMLGLDVHDCAVARTETYVDGVLEPGMVLTVEPGLYFQADDLTVPEEYRGIGVRIEDDILVTEDGNRNLSAGLPRASADVEAWMAALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHA9</accession>
    <name>A0A2G1XHA9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisC</name>
        <name evidence="3" type="synonym">pat</name>
        <name evidence="6" type="ORF">BLA24_17680</name>
        <name evidence="7" type="ORF">CYQ11_15595</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50628">
        <property type="protein sequence ID" value="PHQ50628"/>
        <property type="gene ID" value="BLA24_17680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14117">
        <property type="protein sequence ID" value="PPT14117"/>
        <property type="gene ID" value="CYQ11_15595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="33"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="359" mass="38436" checksum="F9510678C9D22D7B" modified="2018-01-31" version="1">MTEKTPKLRAALDSVPTYKPGKPAAPGGPVAYKLSSNENPYPPLPGVLESAVSAAGSLNRYPDMACAGLMAELAEHFDVPLSHLATGTGSVGVAQQLVQATAGPGDEVIYAWRSFEAYPIITQVSGATPVQVPLTDGDVHDLDAMLAAITDRTRLIFVCNPNNPTGTVVRRAELESFLDRVPSDVLVVLDEAYLEFIRDETVPNGIDLYRNRPNVCVLRTFSKAYGLAGLRIGFAIAHEPVAAALRKTAVPFGVSQVAQDAAVASLRSEDALRERVDALVAERTRVAGALAGQGWTVPESQANFVWLRLGERTLDFAAACERAGVVVRPFAGEGVRVTIGEVEANDLFLRVAEEFRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHF4</accession>
    <name>A0A2G1XHF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17875</name>
        <name evidence="4" type="ORF">CYQ11_15400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50663">
        <property type="protein sequence ID" value="PHQ50663"/>
        <property type="gene ID" value="BLA24_17875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14082">
        <property type="protein sequence ID" value="PPT14082"/>
        <property type="gene ID" value="CYQ11_15400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="17462" checksum="AAAB7F6C2592A682" modified="2018-01-31" version="1">MSTPPPNQNPYAPQGGAPYGQQQPGPYGQQPQAPYGQPAPGPYGQPGGFPGAPVPPPAPKRSFKKIFRNVVIPVIGVGVIVGGWLFGKSDDAKELAVGDCMRNAGTDSKPDVKKLDCSDAQATYKVLKKVDGSTLASLACSGVDGTTAAFTLKERSNSFTLCLGDNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHJ5</accession>
    <name>A0A2G1XHJ5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_18240</name>
        <name evidence="8" type="ORF">CYQ11_15035</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50724">
        <property type="protein sequence ID" value="PHQ50724"/>
        <property type="gene ID" value="BLA24_18240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14021">
        <property type="protein sequence ID" value="PPT14021"/>
        <property type="gene ID" value="CYQ11_15035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="441" mass="45881" checksum="839F418FC86E31BD" modified="2018-01-31" version="1">MAVVREFTLPDLGEGLTEALVVRWLVGVGDVVVVDQPVVEVETAKAMVEVPCPYGGVVTARFGEEGTELPVGSPLLTVAVGETEAAAAVPSGGDEGSGNVLVGYGTQAPMARRRRVNPQAREADRPAAPAAAPTSVAVISPLVRRLARERGVDLSGVRGSGPDGLILRADVEDAARTAPAAHAAQVPQAARPAHRTEAPRSGRRPAAARRAAAGLRVPLRGARGVAAEKLSRSRREIPDATCWVDADATELLAARRAMNAPGGAKVSLLALLARICTAALAKHPELNATVDTDAQEIVTLPDVHLGFAAQTDRGLVVPVVRDAGARNAVELSVEMARLTEAARAGKLSPAELTGGTFTLNNYGVFGVDGSTPIINHPEAAMLGVGRITPKPWVHQGELAVRQVVQLSFTFDHRVCDGGAAGGFLRYVADCVEQPAVLLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL0</accession>
    <name>A0A2G1XHL0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18145</name>
        <name evidence="4" type="ORF">CYQ11_15130</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50707">
        <property type="protein sequence ID" value="PHQ50707"/>
        <property type="gene ID" value="BLA24_18145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14039">
        <property type="protein sequence ID" value="PPT14039"/>
        <property type="gene ID" value="CYQ11_15130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="230" mass="25529" checksum="E26E91236EFBDF06" modified="2018-01-31" version="1">MSDLIVYVDGYNLFHGLRHKFLDDRYQWLDLVSLAQRLRPRDNLIKVNYYTAPLQGASSAVRRQQDYLGALRAVGGKVLAVHEARYQPKTITCKCGRAWRSYEEKETDVHLAVDLVADIATRSADSALVVSGDSDLCPAVRRAREFNAAAHIAMAFPPKRVSTELRALCPRSFVIGPGRIKDAQLPDRVEDPATGRVYERPVGWRPATAGLSSTVPASRKEAPQPHGHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHW1</accession>
    <name>A0A2G1XHW1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18910</name>
        <name evidence="2" type="ORF">CYQ11_14370</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50832">
        <property type="protein sequence ID" value="PHQ50832"/>
        <property type="gene ID" value="BLA24_18910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13910">
        <property type="protein sequence ID" value="PPT13910"/>
        <property type="gene ID" value="CYQ11_14370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="31534" checksum="64FEC487A7A691F8" modified="2018-01-31" version="1">MGLASSVTVPYAAYLRVYEPLAAFPESEREHWTRYARRETLPGAQDELRRSLADLLPVPPVPVPVHESGDAFVAVVDGVVCVCPWRTRLRGWLALEELAERLPPPVLDAALPPVVRRQAEADYARWLERNPDARPWIRTATWQVPLRWFVLFSDEERECGKGDAGEGLRVRYRTPMVQARRRVARGLRTLRDAIEEGPLIDGLVEVGKWLEEFHPRSLVELDYGGLVHMVPEAQLAEDRSAADVAEGLAALRAGDGARAAAAHERLTTRWRAVRDRQFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI43</accession>
    <name>A0A2G1XI43_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16690</name>
        <name evidence="3" type="ORF">CYQ11_16595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50861">
        <property type="protein sequence ID" value="PHQ50861"/>
        <property type="gene ID" value="BLA24_16690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16611">
        <property type="protein sequence ID" value="PPT16611"/>
        <property type="gene ID" value="CYQ11_16595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="8626" checksum="94BE1D9432320F7E" modified="2018-01-31" version="1">MPHAFNGMAASDIEDVVWRKSRYSNSQGSCVEFAKLPGGGIAVRNSRHPDGPALVYTPAEIEAMLLGIKDGEFDYLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIB1</accession>
    <name>A0A2G1XIB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14275</name>
        <name evidence="3" type="ORF">CYQ11_13800</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50957">
        <property type="protein sequence ID" value="PHQ50957"/>
        <property type="gene ID" value="BLA24_14275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13821">
        <property type="protein sequence ID" value="PPT13821"/>
        <property type="gene ID" value="CYQ11_13800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="72" mass="7442" checksum="9736E52103562298" modified="2018-01-31" version="1">MSDELTSGGYGTDVRAWQRSSFCAGGGNNCVELARPAAGPLHLRESEAPGTVIQTNPTALGALIASLKQQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIC4</accession>
    <name>A0A2G1XIC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_14370</name>
        <name evidence="9" type="ORF">CYQ11_13705</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50975">
        <property type="protein sequence ID" value="PHQ50975"/>
        <property type="gene ID" value="BLA24_14370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13803">
        <property type="protein sequence ID" value="PPT13803"/>
        <property type="gene ID" value="CYQ11_13705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304678" evidence="6">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="140"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="535" mass="57399" checksum="2A5495B438A76F56" modified="2018-01-31" version="1">MSFPLLTVTAAVPAAGAVATAAVPAARRVAAKWLALVFSLATLVLAGVQLVRFDPDAKGPFQLTESHAWIKDFGVRYDLGVDGIAVVLIALTALLVPFVLLAGWHDADPLETHSSRWRPTQGFFALILMVEAMVIIAFEATDVFVFYIFFEAMLIPMYFLIGGFGDRAGERGEAESAAQRSYAAVKFLLYNLAGGLIMLAAVIGLYAVTAHQLGTGTFSLQEILQARADGRLDLATSTERWLFLGFFFAFAVKAPLWPLHTWLPNAMGEATSPVAVLITAVVDKVGTFAMLRFCLQLFPEASKWATPVILVLSLVSILYGALLAVGQRDIKRLIAYASLSHFGFIVMGVFAMTTQGQGGATLYMVNHGISTAALMLVAGFLISRRGSRLIADYGGVQKVAPLLAGTFLVGGLATLSLPGLAPFVSEFLVLVGTFSRHPVIGVLATVGIVLAALYVLVLYQRTMTGPVREPVRGMPDLRVRELVVVGPLIALLIVLGVYPKPLTRIVEPAVEHTMSQVHQSDPKPDVHVNDVEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIF1</accession>
    <name>A0A2G1XIF1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YccF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14550</name>
        <name evidence="4" type="ORF">CYQ11_13525</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51005">
        <property type="protein sequence ID" value="PHQ51005"/>
        <property type="gene ID" value="BLA24_14550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13773">
        <property type="protein sequence ID" value="PPT13773"/>
        <property type="gene ID" value="CYQ11_13525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="14089" checksum="235FFB853713ACE8" modified="2018-01-31" version="1">MRLILNVIWLVLCGLWMAIGYAVAGLICCVLIVTIPFGIASFRIASYALWPFGRTAVERRDAGAGSLLGNIIWIVFAGWWLALGHIVTGIALCVTIIGIPLGIANFKLIPISLMPLGREIVPSDRPFATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIH8</accession>
    <name>A0A2G1XIH8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">BLA24_14860</name>
        <name evidence="10" type="ORF">CYQ11_13210</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51058">
        <property type="protein sequence ID" value="PHQ51058"/>
        <property type="gene ID" value="BLA24_14860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13719">
        <property type="protein sequence ID" value="PPT13719"/>
        <property type="gene ID" value="CYQ11_13210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="158"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="31587" checksum="578A1552C35C4070" modified="2018-01-31" version="1">MSDEVEPGYVRVRLDLSYDGKDFSGWAKQREGQRTVQGEIEAAIRTVTRSKRTYELTVAGRTDAGVHARGQVAHVDLPAEVWAEHEDKLLRRLAGRLSHDVRVWKVAEAPAGFNARFSAIWRRYAYRVVDHPAGVDPLLRGHVLWHDWPLDVDAMNEASRALVGEHDFAAYCKRREGATTIRTLQRLSWERDASGVITATVRADAFCHNMVRSLVGAMLFVGDGHRPVEWPGQVLAAGVRDSAVHVVRPHGLTLEEVGYPADSELAARNLAARNKRTLPGAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIX9</accession>
    <name>A0A2G1XIX9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15635</name>
        <name evidence="3" type="ORF">CYQ11_12440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51187">
        <property type="protein sequence ID" value="PHQ51187"/>
        <property type="gene ID" value="BLA24_15635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13590">
        <property type="protein sequence ID" value="PPT13590"/>
        <property type="gene ID" value="CYQ11_12440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="213"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="610" mass="65524" checksum="69B05172097F15D3" modified="2018-01-31" version="1">MNQGQGWFVVLPDTAEATPAAGVLTSRTPGLRTEPHPSGRPWVLGRWSPDEMTVVTAGCGRVALIGDHTPPDGRLKDAIGRARTAQELDRVMSGVPGCFHLVSSLGGHVRARGTASGMRRLFHARVAGVTAGCDRADVLATAVGGTLDEDALLLRLLEPAVPHPLGGRPLWREVTAVPPGHRLHLDPWGGARVTRWWHEPEPRLSLAEGAPGFAQALAEAVGVRTAAGGVVSADLSGGLDSTPVCFLAARGPAELVAFTQEGIDGGHEDALWARRAASHLPDADHVLLEPGGLPPFYSGLLTAGEGTDEPALGARVRGALTGLARLMAARGSRLHLTGEGGDQVVQAMDSYVHDTLRTRPRTGLRHLRALSAECRWSAAATLKAATDRRSYRRWLTDAASDLRPVRVSDRRPTMTGWDVPPTLPPWVTPDARERLTRLLRRHAATASPLAPTRGRNMALALILASTRMCRQIARFTAEAGLPFHYPFLDDRVVEAALAVRLHERTTPFAFKPLTVAAMRGVVPDDVLARRDKSEFSREVHSGLAARRSEVAELLADSRLARLGLVDADGLRQAALVLHPPHLPITYLEMTFAVETWLRAHAQAPAKAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIY7</accession>
    <name>A0A2G1XIY7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_15780</name>
        <name evidence="5" type="ORF">CYQ11_12295</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51214">
        <property type="protein sequence ID" value="PHQ51214"/>
        <property type="gene ID" value="BLA24_15780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13562">
        <property type="protein sequence ID" value="PPT13562"/>
        <property type="gene ID" value="CYQ11_12295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304905" evidence="2">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="150"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="283" mass="28242" checksum="F54B9CA9463C2B00" modified="2018-01-31" version="1">MTPLVVVAVLVAAVAHASWNAVAHGIKDQLVAFTLVGGGGALCGAALLPFAPAPDAGAWPCLLVSALLHVVYQGLLMRSFSLGDFGQMYPIARGTAPLAVTALAAVFAAELPDGPQLAGVAVASAGLVGLALWGIRGSGARPDWTAVGAACATGLAIAAYTVVDGLGVRASGSPLGYIAWLMILEGLVIPAYAVGTRRGGFLAQVRPFAVRGLAGGLLSVFAYGLVLWAQTRAALAPVAALRESSILVGAGIGAVFMKERFGAPRVAAAGLMVAGIGLMLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ02</accession>
    <name>A0A2G1XJ02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1524 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15735</name>
        <name evidence="4" type="ORF">CYQ11_12340</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51205">
        <property type="protein sequence ID" value="PHQ51205"/>
        <property type="gene ID" value="BLA24_15735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13571">
        <property type="protein sequence ID" value="PPT13571"/>
        <property type="gene ID" value="CYQ11_12340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758488" evidence="2">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="317" mass="34113" checksum="B6DA5C57A883D055" modified="2018-01-31" version="1">MRRVRKPSATSAVSAISAVALLAVLPGAAVAAGPPAGPDAAAPRQHGPAGHGARAANAPQDYAEAACEGPPPEEGDVYTRPPTTSPHSTPPKTSQKGTAPQGSTPPQQAKGAAPKRPAKKPASRRALPHKWPRGVPGRDEAVRMLDDLTVRPFNGKGYDHRLFTGSSCWVQHGVDRCTTRQIALRFHSVTPVKLDGPCKVVGGEWHSEYDGRTMADPLHLDVDHVVPLRNAWGSGASAWSFEERREFANDLVASPQLIVVSTWSNRAKGDKGPDQWLPKGAECTYSRAWIGVKDYYRLSVTRAEKDKLRQVLDTCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ93</accession>
    <name>A0A2G1XJ93_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16255</name>
        <name evidence="3" type="ORF">CYQ11_11820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51293">
        <property type="protein sequence ID" value="PHQ51293"/>
        <property type="gene ID" value="BLA24_16255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13481">
        <property type="protein sequence ID" value="PPT13481"/>
        <property type="gene ID" value="CYQ11_11820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="106"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="283" mass="31012" checksum="4B6FA5E1E0A42A95" modified="2018-01-31" version="1">MSSPSPSSSVAAARKALADRLVEIRKDAGITGQELSVRCGWNAAKTSRIQSGKATPTDADIRAWCAACGTENQAADLIATARAADSMYVEWRRRHRTGLRQAQERLISGYEETSLFRIYVSNVIPGFFQTPAYATALMRSMTDFHETPDDVAAAVPARMARSRLIYEGGHRFAVLIEEWVLRSQIGDTETMAGQLRHLLSLMPLASVSLGVIPSAGQRKVWPLEAFYLFDDRRVAVENLTAKINVVQPREIADYAKAFHELSGMAVYGPRAQALITAAIEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJA6</accession>
    <name>A0A2G1XJA6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">BLA24_15810</name>
        <name evidence="10" type="ORF">CYQ11_12265</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51219">
        <property type="protein sequence ID" value="PHQ51219"/>
        <property type="gene ID" value="BLA24_15810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13557">
        <property type="protein sequence ID" value="PPT13557"/>
        <property type="gene ID" value="CYQ11_12265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="43"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="30520" checksum="982F7E68759CCD95" modified="2018-01-31" version="1">MSSPSTDESGALLGPADIRELAAALGVRPTKQRGQNFVIDANTVRRIVRTAEVRPDDVVVEVGPGLGSLTLALLEAADRVTAVEIDDVLAAALPSTIAARMPGRADRFALVHSDAMHVAELPGPPPTALVANLPYNVAVPVLLHMLDRFPTIERTLVMVQAEVADRLAAAPGNKVYGVPSVKANWYAEVKRAGAIGRNVFWPAPNVDSGLVSLVRRTEPIATTATKEEVFAVVDAAFAQRRKTLRAALAGWAGSAAAAEAALVAAGISPQARGEALTVNEFAAIAEHKGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL2</accession>
    <name>A0A2G1XJL2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13880</name>
        <name evidence="3" type="ORF">CYQ11_01575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51417">
        <property type="protein sequence ID" value="PHQ51417"/>
        <property type="gene ID" value="BLA24_13880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11758">
        <property type="protein sequence ID" value="PPT11758"/>
        <property type="gene ID" value="CYQ11_01575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="9548" checksum="2FAC6EBD1242A2C1" modified="2018-01-31" version="1">MVVLALAALAVAFTTAFAFGRLVTWLTRGLPRVAGVLLSVLVTFASAYAVVWLTWPSYLSVLFMLLWWAGSLSGNVAAWLRRPAGRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL8</accession>
    <name>A0A2G1XJL8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13770</name>
        <name evidence="4" type="ORF">CYQ11_01465</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51400">
        <property type="protein sequence ID" value="PHQ51400"/>
        <property type="gene ID" value="BLA24_13770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11740">
        <property type="protein sequence ID" value="PPT11740"/>
        <property type="gene ID" value="CYQ11_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="208" mass="22353" checksum="04A5254D5E501E03" modified="2018-01-31" version="1">MTAKPTGPGRGPAATGKGTERRVLLLDVAERILTESGHGALTMRAVATAAEVRLGHLQHYFPTRADLVAAVLRRCLDASLERLAPLLTGSGPGGRTAPDVLVRRLLAEQDDPLVVRLYAEVWALAARDEAVATVVRDFYDGYRSHVADYVGSRQPGLPEDVRRVRADVFVMLVEGAALFRSGIAGHRRESTDTELVTRAVALLEGPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJZ8</accession>
    <name>A0A2G1XJZ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12690</name>
        <name evidence="3" type="ORF">CYQ11_17045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51556">
        <property type="protein sequence ID" value="PHQ51556"/>
        <property type="gene ID" value="BLA24_12690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14346">
        <property type="protein sequence ID" value="PPT14346"/>
        <property type="gene ID" value="CYQ11_17045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="519" mass="57322" checksum="0FBE25F1C80032FD" modified="2018-01-31" version="1">MTVPAQSQPIAARRTYLIGRARPNAVVGKNRETGEITLIIAGAFVGMMCGLLVPVLPLRIVTLTGFPALSLAAVYVPYKGRTFFKWFEINRSYKRTLRHSATYRSAASEAGTRLDGREVEVGPPPGIGRITWLAAPFGPDEIAVLLHADRRTVTAAIEIEGPGVGLRDSEDQEALVERFGTLLKHVANGDGYVTRIQMLARTLPADPDAHAKDVERRGDGRAPDWLKDSYDQLQSMVSTSSEQHRAYLVACMHYSRELAAEAQAIARASRHDGGKRRLDRDGGLAVVMARELTDICARLAEADIRVRQPLGQGRLASLVHSMYDPDHPIDHIQAMTKRNAWPAELDAMEPTYLQAKTRESTTRAPWCHSTAWVKEWPMTPVGVNFLAPLLVHTPDVIRTVAVCMDLEPTDVAIERMLTEKTNDDADASRAAKMNRVVDPRDVAHHSRVDQRGEDLASGAAGVNLVGYITVSSRSPEALARDKRTIRASAGKSYLKLEWCDREHHRAFVNTLPFATGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK33</accession>
    <name>A0A2G1XK33_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pstS</name>
        <name evidence="7" type="ORF">BLA24_12775</name>
        <name evidence="8" type="ORF">CYQ11_17130</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51570">
        <property type="protein sequence ID" value="PHQ51570"/>
        <property type="gene ID" value="BLA24_12775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14362">
        <property type="protein sequence ID" value="PPT14362"/>
        <property type="gene ID" value="CYQ11_17130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305593" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="30"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="56"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="38927" checksum="3D8B9E5AB1C2FFD8" modified="2018-01-31" version="1">MKLQHKNRLRTVALGALAVSGALVLTACGSDDNSGGGNGGGSGSTKAAGNIKCEGKGQLLASGSSAQKNAMDLWVKNFMAACKGIQINYKPTGSGAGIQEFLQGKTAFAGSDSALKPEEVAKSKEVVKGGQGINLPMVGGPIAIGYNVPGVDNLVLDADTLAKIFDGKIEKWNDEAIAKLNKDAKLPDLKIQPFHRSDESGTTDNFTKYLKGAADKSWPYEPAKAWKAKGGQSADGSAGVSSQVKQTSGAISYFELSYATANSIKTVKLDTGASAPVEATSDNASKAIAEAKIVGTGKDLALKLNYTTKADGAYPITLVTYEVVGDQGNKADTLPATKSFLTYIASQDGQAVLKDLGYAPLPAEIAAKVRETVAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKD2</accession>
    <name>A0A2G1XKD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_11365</name>
        <name evidence="6" type="ORF">CYQ11_02600</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51687">
        <property type="protein sequence ID" value="PHQ51687"/>
        <property type="gene ID" value="BLA24_11365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11936">
        <property type="protein sequence ID" value="PPT11936"/>
        <property type="gene ID" value="CYQ11_02600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="269"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="303"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="506" mass="52755" checksum="68F0B6143A5713A3" modified="2018-01-31" version="1">MTPEDVPLPMTEPTTPLAEARGLAIRLPGGPVLLPPTDLTLAPGTVTALTGPSGSGKTTLLRALAGALPPRAEVAAGTLTVLGHDVLRLPAAELRALRRHRIAHVGQDPASALNPRMRVRRIVTELAGTADAGTAARLLAECRLDPRDGLLERRPGALSGGQQRRVALARALARAPEVLLLDEPTAGLDHRLRDEIADLLRELATARHIGVLLTCHDPGLVDRCADHAVALTSPHHPAPRAATPEPAAPAIRAATAPSSTAPRSGGLTARGLRVTFDRRRTGRPALADVDFTAPAGTTTALIGASGSGKTTLLRVLAGLRRPDGGTLTLAGAPLPTVNRKRTGEQRRGIQLVPQNPLGCLNPARTVGAIVARPLTLHRTVPAAAVPGRVARLLEDVGLSADHAHRRPAELSGGQRQRVALARALAPGPEVLLCDEITSALDPDTAHSVMRLLARIQAAHGLTVVLVSHELHLVAAYADTVHLLDGGRVTHHGPTADVLDAALPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKJ3</accession>
    <name>A0A2G1XKJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11740</name>
        <name evidence="4" type="ORF">CYQ11_02980</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51752">
        <property type="protein sequence ID" value="PHQ51752"/>
        <property type="gene ID" value="BLA24_11740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12000">
        <property type="protein sequence ID" value="PPT12000"/>
        <property type="gene ID" value="CYQ11_02980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758363" evidence="2">
        <location>
            <begin position="24"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="338" mass="35733" checksum="76047735F1DD7F67" modified="2018-01-31" version="1">MRSRLFVAAFTAVALLTACGGGGTDPGPDAESPHAARADGAELLFRGGGRASAQNPAFSPDGASVVFTLFREGYNEGAAALRVLPLGARGTARAKPTTLLDEADRAAVNLPGSSWSPSGEVAFASDRAGRDEVWVLRPGGEPARVTAHEGASGYLEPSFSPDGAWIVFQESVEREGSGDHAGSGSLWKVRRDGTGAVRLLDGPATRSDNRQPNWSPKGDKLVFQRREGDGDWALYTVNADGSGLRRLTRGRGEHTDPSWSPDGRWVVFSSTEGGLDLPQIFVTPADGGGRPVRVTRDDGRYDGAPSWSPDGRWIAFESHAGDEDRPSSLWRIPAPGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKV2</accession>
    <name>A0A2G1XKV2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_12260</name>
        <name evidence="9" type="ORF">CYQ11_03495</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51865">
        <property type="protein sequence ID" value="PHQ51865"/>
        <property type="gene ID" value="BLA24_12260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16329">
        <property type="protein sequence ID" value="PPT16329"/>
        <property type="gene ID" value="CYQ11_03495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="326"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1843"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3598"/>
            <end position="3673"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1878"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="3750" mass="389036" checksum="EF6F6A6F8A6676E7" modified="2018-01-31" version="1">MFEQGALEPLPVKAWDVRRAREAFRFVSQAKHVGKVVLTVPRELDAEGTVLITGATGTLGGLVARHLVAERGVRNLLLVSRRGADAEGAAELEAELAELGAQVRFAACDVADREALAGVLGSLERPLTGVVHTAGVLDDGVISSLTPERIDGVFRPKVDAATNLHELTRDLDLAMFVVFSSAAATFGGPGQGNYAAANAFLDALAQHRRAQGLPGQSLAWGLWAQRSAMTGDLDDTDLARMGRVGAGALSAEHGIALFETSSTMDEALLVPIPLDGAALRGGGDVPPLLRGLVRTTVRRTAASRGTAEVSGLAARLTGLAEPEQREVLLDVIRGHVAAVLGHASPDMVDPARQFRELGFDSLTAVELRNRLSSATGLRLTATLVFDHPTPWVLVDHLRSELLGDAAEIAAPVAAPAAATDDDPVVIVGMACRYPGGVSSPDDLWRLVSTAGDAISAFPQDRGWDMEGLYDPELDRAGTTNTQEGGFLEGVADFDPAFFGISPREALAMDPQQRLLLETAWEVFERAGIDPASVRGSLTGVFAGASASGYGTGAAEIPDDIEGYLMTGTTTSVVSGRIAYTFGLEGPAVTVDTACSSSLVALHLAAQAIVNGECTMALAGGVTVMGTTGVITEISKQGGAAGDGRCKAFSAAADGMGSAEGAGLILLERLSDARRNGHEVLAVVKGSAINQDGASNGLTAPSGPSQQRVIRQALANARLSGAEVDVVEAHGTGTALGDPIEAQALLATYGQERDADQPLWLGSVKSNIGHTQAAAGVAGIIKMVLALRAGVLPQSLHIDEPTPHVDWASGAVELLTEARDWPETGRPRRAAVSSFGISGTNAHVIMEQAPAAPQTAPVEQAPTTGVVPWVLSGKSTAAVRAQAARLAEHVRTRGELSPLDVGFSTLTTRAALEHRAVAVGPDHMAGVAALAAGEALPGVVEGVADVRGKVAFVFPGQGSQWVGMARELIETSPVFAERMRECATALSAYVDWSLFDVLDDAEALERVDVVQPVLFAVMVSLAELWRSYGVKPAAVVGHSQGEIAAACVAGALSLDDAAKVVALRSKAILALSGLGGMVSVGLPVEQVRERLTGGLSIAAVNGPRSVVVSGDVAELDALLAACEADEVRARRIPVDYASHSAHVEAIRDELLTVLVGLAPRAAEVPFFSTVTADWFDTIGLDAEYWYTNLRETVRFEEATKALVEQGYRFFIESSAHPVLTFGVQETVDAAGSDAVTLGSLRREEGGLVRFATSLAEGWVRGLAVDWSPMIAGGQAVDLPTYAFQRQRYWLETAAATADASAPDVIEAKFWAAVERGDVTALAETLDVVEQESLSAVLPLLSSWRRRRVEQSRVDEWRYTVSWKPLSVDSTVLSGRWLVVSAGGDVVSEVLERAGTEVVRLAVDAAEVSRPVLAERLAGVEVDGVVSLLGLDDTALSDLPVVSRGLSATVALVQALGDAGVAAPLWLLTRGAVSVGRSDRLTSTVQAQVWGLGRVVGLEHSERWGGLVDLPEGLDERAAGRLVALLAGGAGDEDQIALRSSGVFGRRLVRSPLGDAAPVRAWSPRGTVLITGGTGALGGHVARWAAGKGAEHLVLTSRRGLEAPGAAELVAELTELGARVTVAACDVADREAVAELLAEHTVNAVVHAAGVGQFADLSDLDTRALADVLAVKVAGARHLDELLDDTELDAFVLFSSNAGVWGGGRQGAYAAANAYLDALAEDRRARGRTATSVAWGAWAGGGMLTAGTSEEGLRRRGVLPMAPELAVSALVQAVEHDETFVAVADVDWARFVPGFTSARPRPLISDIPEARAALDSTAPATGDDEPADDSLTQRLAGLSAAERLRVVLDLVRGAAASVLGYASAEDVERNRAFREMGFDSLTAVEVRNRLATATGLKLPATVVFDYPSPAVLADFLLGQVAGTGVTAATSATPAVVAVDDEPIAIVGMACRFPGDVRSPQQLWDLVATGTDAMSPFPADRGWDVEGLFGSDFAHLGGFVYDAGEFDPVFFGISPREALAMDPQQRLLLEAAWELFERAGIDPTSLRGSQTGVFAGASTSGYGSGLTQLPEGVEGYALTGSSASVVSGRVAYTLGLEGPAVTVDTACSSSLVALHWAAQSLRNGECSMAVAGGVAVMSTPGAFMEFSRQGGLAGDGRCKPFADAADGTGWGEGVGLLLLEKLSDAERNGHQVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANAGLSASEVDVVEAHGTGTTLGDPIEAQALLATYGQERAEDRPLLLGSVKSNIGHTQAASGAAGIIKMVMAMQNGMVPESLHVDRPSTHVDWTAGAVELVTENTAWPETGQPRRAGVSSFGVSGTNAHIILEQAPAVGTSEAVRTPAPEGVVPWLLSAKSANALKAQAERLLAELTDDASPVDTGFSLATTRAALEHRAVVVGKHRDELLRGLTAVAEGTPGAGVARGVVPEPGLTAVLFSGQGSQRAGMGRELYDAFPVFAEALDAVCAEFDRVLERPLREVMFEQGEALDQTGFTQPGLFALEVALYRLVESWGVRPDYVTGHSIGELAAAHVAGVLTLEDAVTLVAARGRLMQALPAGGAMLAVGTDEATVAAQLEGREAQVSIAAVNGPSSVVIAGDEDVVTELGEVFAQAGHKTRRLRVSHAFHSPHMDAMLENFRLVAEGLTYEQPSIPVVSNLTGQAEDVASADYWVRHVRGAVRFGEGVRWLEDQGVSVFLELGPDGVLSGMAQESVTGDPALVAALRKDRSEPEALVTALGRLHVAGVDLDWGTFFTGARRVDLPTYAFQHQRYWLESGAPTGDVVPAGLTAVEHPLLGAAVPLADADGFLLTGRVSLSTHPWLAGHALSGTVLVPATAFVELAIRAGDEAGCDQLEELTLQAPLVLPQDGALQVQLVVGADDGSGRRPLTLHSRAADAGRDEPWTQHAAGILAGGGAPEGERLDVWPPAGAVEVSVEELYAGLADVGFAYGSAFLGLRSVWRAEDGVYAEVALPDEHRDAAGAFGLHPALLDAALHPLGLGVDGGAEETGTGPQGAGLPFAWTGVRLHASGATALRVRLTPAGDDGVAVLAVDETGAPVASVESLVLRPVSDDQLAATDTIRRDALFAVEWVPAPAAPSVASATYAVLGADEPELAAALTAGGGTGSEEPDLAALVKSVAAGAPAPELVFAPVASGLDANAPEPAGNAAGVRTVTGQVLELVQAWLGEERFESSRLVLVTRGAVTTDETTAGVADLAGAAVWGLIRSAQSENPGRLVLVDVDDTPESFFALAGVAASGEPQVALREGDALVPRLTRAAAPEAAPVPLDPDGTVLVTGATGTLGGLVARHLVTEHGARHLLLVSRRGGDAEGAEELEAELTGLGAEVRFAACDVADRDAFAGLLGSLEQPLVGVVHTAGVIDDGVLPALTPERLDRVFRPKVDAALNLHELTRGYDLALFVLFSSAAATLGSAGQANYAAANAFLDALAQRRRAEGLPATSVAWGMWAERSGMTGDLGEADIARMSRGGFGALSSAQGLALLDAAAATDTAALVAVRLDLPALRASAGPDELPALLRGLLPASGRRTAAGGTATASTGDDLTRRLSLLSEAEQEAELLDLVRAHVAGVLGYGGPEEVEPGRTFQEIGFDSLTAVEFRNQLTAATGVRLAATVIFNYPTPTAVAGHLRSRLGTTVAAGAGTSELDSLERLLSEESLGGQARTRITERLQALLTKWGPDVEQEDQVADELDAASDDEVFDFINKEFGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKX4</accession>
    <name>A0A2G1XKX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11145</name>
        <name evidence="2" type="ORF">CYQ11_16860</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51885">
        <property type="protein sequence ID" value="PHQ51885"/>
        <property type="gene ID" value="BLA24_11145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14314">
        <property type="protein sequence ID" value="PPT14314"/>
        <property type="gene ID" value="CYQ11_16860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="84" mass="8447" checksum="541B90872A54FEB0" modified="2018-01-31" version="1">MSGQAGVRRRRSGGGRICLACGNIVSHHRVGGDVGCSAAGFPANAGVIRTGVGSWNELSRPAGLACGRTGRGPTPNCLTALRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLG1</accession>
    <name>A0A2G1XLG1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_09780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000100">
        <property type="protein sequence ID" value="PHQ52057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52057">
        <property type="protein sequence ID" value="PHQ52057"/>
        <property type="gene ID" value="BLA24_09780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="275" mass="29431" checksum="64AF290015474B6F" modified="2018-01-31" version="1">MRSVRPTHATTAGLIRTLARWTRPEGGRPAAGRAVGTWLVVGALAATLVALLVPVSLFGSARPAAAAGPAWSDDGAGVQNTAFGPLSALDRDFVRKVRLAGLWEKPAGRLAQERGTTEDVRVAGEHLIGGHTELDRRSLDAGRVLGISLPDRPSAQQQGWLDQMDAARGTAFDRAFAQLVRAAHGKVFGLVALVRDRTGNSLVRELATRANTVVLDHITVLENTGQAGVPHTDPRPASPAGTPAMPRHPPRRTIPPRRRILLPRRHRRGSTATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLH8</accession>
    <name>A0A2G1XLH8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ORF">BLA24_09205</name>
        <name evidence="5" type="ORF">CYQ11_27815</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52092">
        <property type="protein sequence ID" value="PHQ52092"/>
        <property type="gene ID" value="BLA24_09205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16172">
        <property type="protein sequence ID" value="PPT16172"/>
        <property type="gene ID" value="CYQ11_27815"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="65"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="304"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="412" mass="43375" checksum="7364C2D536999CC2" modified="2018-01-31" version="1">MAGNSGPLSPRAKLAVTAGKAAAAVSRAAGRGSGSVIGGKVALKLDPDLLARLATHLDVVLVSATNGKTTTTRLIAEALRASGPVVSNALGANMPAGITSALAGGSDARYGVIEVDEKYLAGVARDVAPKAIALLNLSRDQLDRAAETRMLAEKWREGLAGTKAVVIANADDPLIVWAASSSPNVVWVAAGQEWKDDAWSCPSCGGVMQRPGDDWFCGECGFRRPNPSWALSGDYVLDPHGSAWPIHLQLPGRANKANATTSAAVAATFGVPPQVALERMYQVQAVAGRYDVVTFLDREVRLLLAKNPAGWLETFSLIDGPPAPVILAVNARGADGTDTSWLWDVDYTRLAGHPIMVIGDRKLDLAVRLEVAGVDFRVCETVDEAVQGCPPGKIEVIANYTAFQDIRRRVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLK3</accession>
    <name>A0A2G1XLK3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fe(3+)-hydroxamate ABC transporter permease FhuB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Fe3+-hydroxamate ABC transporter permease FhuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_09385</name>
        <name evidence="9" type="ORF">CYQ11_27995</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52123">
        <property type="protein sequence ID" value="PHQ52123"/>
        <property type="gene ID" value="BLA24_09385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16203">
        <property type="protein sequence ID" value="PPT16203"/>
        <property type="gene ID" value="CYQ11_27995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="732" mass="73472" checksum="61AE1CD8208227E3" modified="2018-01-31" version="1">MTVSHVDPGAKAVADEALPAPSGGRRPLLLASASLVLAVLVLAALSLSVGAGEVGPGDVLDYLLGRDGARADTRLALVVGDLRIPRTLTALLVGAALGTSGSLLQAVTRNPLAETGLLGVNAGASLGVVTGIAFLGVTSGYGHLLWAFGGAVAASGLVLLIAGRRGGGSPMRLVLAGSALGATFGGVTSVVIVNSAETYDRFRFWVLGSLAGVEGYSELKSLLPVLALGFLVALLVARPLSALALGDDLARGLGHRPSVIRVVVAVAVTLLTASAVALVGPVSFLGLLAGFLARAVTGPRLTAQILLAGLVGAGVLTGADVLARVVSRPFEAPVSVIIALVGAPVLIGIVRSKRLGAMGMTDPATEESAKPARRLLPRLGTPRTADAGAADTDSLVLRRGTLSVLLPRRAALAALFLAALLVTAVVLSAYAGQSEMSLSRTFNAVFGSGDRFDVLLVQKFRLGRIVAGLTAGAALGLAGCLTQTLARNRLATPELLGVNDGATAAVLLSTTLTGTFGAWWAGPVGALAAVLVVTTVSGGLGQRGYRVLVVGLAMSALASAVTQVVLSRRSLNAASSLYVWTSGSLNGRGYSVATPVLIGLAVLVPLALVVARQLNVLRFDDSTASSLGVAPGRVRLVCLLLSVGLAGLAVGICGPVGFVALASPVIAGRLAGPLRVPVVGSMLTGAVLIVLADTVGRIVFDGVEVPVGIVTTVLGGPFLLWVLLGRSAATRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM5</accession>
    <name>A0A2G1XLM5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_09495</name>
        <name evidence="9" type="ORF">CYQ11_28105</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52142">
        <property type="protein sequence ID" value="PHQ52142"/>
        <property type="gene ID" value="BLA24_09495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16223">
        <property type="protein sequence ID" value="PPT16223"/>
        <property type="gene ID" value="CYQ11_28105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="66"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="506"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="743" mass="76649" checksum="4B0779FA132E8806" modified="2018-01-31" version="1">MSSPADVETPAPALAPADAGAANRAGEALRRLRPWLVPAASAAVTLLLALAGAGTSERLANGGYTATGTESARAAALLADRFGAGNPDVVLLVRARGGVDSARAREAGLRLTERLEHARGVASVRSYWTAPDPALRSADGSAAVVAADLEGADRDAARTADTLVPRLTGGHGVLDVAATGPSWVSVEARRASEADLVRAELVAAPVTLLLLVIALRSLVAALVPLAIGAVSVVGTAALLRLLTTLMPVSVFAMNLTTALGFGLGVDYGLFLVTRFREELRAGGPVANAVRRTAQRAGRTVAVSAAAVALSMSALLVLPLPFLRSMACAGMGVALFAAAAATVLVPPLLTLLGTRVDRGDPLALLRRRRPAREARPDSPVWRTIARAVTKRPLCYGGGCAVALLLLAAPFGHVRFGLPDERVLPASAEAHRTAEEIRAGFAAPAGQGLTVVLPEADPVRDGAALRAYGRRVAALPSAGRVDWARPAGRVGAVRGAVLRVGGPREPQSAAAQRLVERLRALPGPGGERLVTGRAAFLLDTRAAVRARLPLAAAVAGVTTWAMLFLLTGSLLLPVKALVIGALSLGASFGAMVYVFQEGHLRRLVGDFTVTGTLDVTVPPLMFVIAFGLAIDYEIFLLSRVREGYLLTGDNRRAVVEGVARTGRLVTTGALAVAVVTGALATSGVSVLKLLGTGLATAVLVDAVLVRGVLVPAYLVLAGRLNWWVPPWLGRVHARVAGRLGLAGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLS6</accession>
    <name>A0A2G1XLS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hppD</name>
        <name evidence="7" type="ORF">BLA24_09595</name>
        <name evidence="8" type="ORF">CYQ11_28205</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52160">
        <property type="protein sequence ID" value="PHQ52160"/>
        <property type="gene ID" value="BLA24_09595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16241">
        <property type="protein sequence ID" value="PPT16241"/>
        <property type="gene ID" value="CYQ11_28205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="147"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="339" mass="36132" checksum="415D8DDCB1269613" modified="2018-01-31" version="1">MAALDIEYVELYAHDEAATVGYLAGSLGFRRVARAGRPGLETVLLRQGTVQVLVSTGPAAGRFLEEHGDGVADMALRCDDVAGTLASATAAGARELGDAVGGPAVTGFGGVRHTLFPDGPDAATRLPAGRAWTPLSAAAGPVERISVLDHVAVVLEAGTLQDHTEFYERGFGLGRYSGEYVAFGDQAMDSVVVRSASGGITFTLIEPDKKKQAGQIDAFLDKNNGPGVQHLAFLVDEIVPAVHELRGRGVDFLSTPAAYYGLLERRFPEMAGEIADLKGADVLADRDEWGYLLQLFTRSPYARGTLFYELVQRRGSRGFGSSNIRSLYEAIELDRVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLW3</accession>
    <name>A0A2G1XLW3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09415</name>
        <name evidence="6" type="ORF">CYQ11_28025</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52129">
        <property type="protein sequence ID" value="PHQ52129"/>
        <property type="gene ID" value="BLA24_09415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16209">
        <property type="protein sequence ID" value="PPT16209"/>
        <property type="gene ID" value="CYQ11_28025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304716" evidence="3">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="4">
        <location>
            <begin position="92"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="235" mass="24184" checksum="CF6D4A85A2BD3923" modified="2018-01-31" version="1">MTGRRSAAAVVAACAVMVLAGLTTLVTAAHGAPLMVDRELHHTALEHRSGLVSAAARALTSTGTGLFPYAVAAAAGWLACRPGRPAPRRLPVVLAAVAALGLGQVVRIGMRTAVDRPRPPAPDWVTEAHQAAFPSGHATTSALAAGLLAWALLRAAPRRAGRAAAACCGLWAVGVAGTRVYLGVHWPTDVAGGWLLATCWLALTLPVLARVADDPGSSSLLPSSWRSRRRKARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM21</accession>
    <name>A0A2G1XM21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000087">
        <property type="protein sequence ID" value="PHQ52314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52314">
        <property type="protein sequence ID" value="PHQ52314"/>
        <property type="gene ID" value="BLA24_08285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="83" mass="8988" checksum="1EC35D574EDFEBCC" modified="2018-01-31" version="1">MRRGSRVRLRPVGRADVLDPSLTGRVAEVTELTEDLEGRVQLVVSLDGDAGRDFATAWATASSSHPRKWNPSSARPPRPPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMF1</accession>
    <name>A0A2G1XMF1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_08110</name>
        <name evidence="7" type="ORF">CYQ11_00550</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52396">
        <property type="protein sequence ID" value="PHQ52396"/>
        <property type="gene ID" value="BLA24_08110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11597">
        <property type="protein sequence ID" value="PPT11597"/>
        <property type="gene ID" value="CYQ11_00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304919" evidence="3">
        <location>
            <begin position="32"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="5">
        <location>
            <begin position="56"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="4">
        <location>
            <begin position="213"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="540" mass="58320" checksum="DD0A5C30942CC1EA" modified="2018-01-31" version="1">MTITRRSVLKGSSAAAAAVPFVTSAAGEAAASPSPTTPGPLLQSRPHRLGAPGVLGVHLQFGSDPSSEMTVSWITPQSVRRPQVRLGSPEGGHGGRLVEAETRTYRDGLSKEEVYVHHARITGLRPSATYLYAAGHDGATPETGSFTTAPRGRAAFTFTSFGDQATPNLRRVIHLPDGVPSPVNRFPLHTSSQVGSPASADIVSAVERVAPLFNFVNGDLCYAAIAGAWGTSRAATWADWFINNSRSTRLRPWMPCVGNHENEKGNGPIGAAGYQTYFALPSSSASSDEETRGMWYAFTVGAVRFISLANDDVALQDGGDTYISGYSGGAQRRWLERELKAARADRGIDWVVVCMHQPMISSHRSAGSDLGVRRAWGPLFDAYGVDLVVSGHEHHYERSHPVRGTLPNEARTPLPVSTRTDLIDTGKGTVHMVIGAGGNIATSQDDLFDTPQARVLVGLKDDKTSSGHREPVWIPEEAPWAAVQDRKYNRGFAAFDVDPGDRREGLTRMRVTYYTFDGPHGDLTPVDTFTLQRPRSDARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMP5</accession>
    <name>A0A2G1XMP5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_06780</name>
        <name evidence="5" type="ORF">CYQ11_26930</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52480">
        <property type="protein sequence ID" value="PHQ52480"/>
        <property type="gene ID" value="BLA24_06780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16013">
        <property type="protein sequence ID" value="PPT16013"/>
        <property type="gene ID" value="CYQ11_26930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305609" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="69"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="33284" checksum="B7011FA222B3DC33" modified="2018-01-31" version="1">MERPGPFALRGLAALVLGLLTAVAALPGPAASASPVRSAPRAAAAAADSYWTPERMRAAAPAAGDGRRATGGRASDVPPSHPFDGLPQVGTFFWTDGNNTGRFCGGTVVRSPHRDLAVSAAHCLRSPAPKKHLSFVPQYHDGRKPHGVFPVEDIYIDERYYDLGTDGGARWDYTVVRLGERADGTAVQRAVGGFGLAIRPGYDHEDVRLIGYPGNSDATYPKPLDCRSSTHRYTSTDPRAPGDFLEIACAGYVGGTSGGPFLVRGGSGYELIGVIGGYHTGGDTPDISYSSYFTGDLLALYLHAVAGDPPAEPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR7</accession>
    <name>A0A2G1XMR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07170</name>
        <name evidence="4" type="ORF">CYQ11_27325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52545">
        <property type="protein sequence ID" value="PHQ52545"/>
        <property type="gene ID" value="BLA24_07170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16083">
        <property type="protein sequence ID" value="PPT16083"/>
        <property type="gene ID" value="CYQ11_27325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304977" evidence="2">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="31028" checksum="CAEB724BE0EFBF4B" modified="2018-01-31" version="1">MSRTRRAVVLTLGAALAGSFTTPAVAESRPVAETGRGGPPLRNAHAHNDYAHPHPLTDALAHGFNSVEADIWLVGDKLLVAHDASGLDPRRTLEALYLDPLLRRVRANHGRVYAGHDLSLQLLIDIKTAGDATYRALSRHLRPYHSMLSSCTGGRVHRDAVTAVVSGDRGARAPMAAEHVRHAFYDGRLSDLGGAPASFAPLVSDDWSHTFTWQGVGPMPARERAALTRIVTTAHAERRHVRFWATPDVPGPARTALWRELLAAGVDYLNTDDLAGLEAFLRAAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT1</accession>
    <name>A0A2G1XMT1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_07125</name>
        <name evidence="9" type="ORF">CYQ11_27280</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52538">
        <property type="protein sequence ID" value="PHQ52538"/>
        <property type="gene ID" value="BLA24_07125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16076">
        <property type="protein sequence ID" value="PPT16076"/>
        <property type="gene ID" value="CYQ11_27280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758517" evidence="6">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="98"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="33519" checksum="52FB3843CA086DB1" modified="2018-01-31" version="1">MARMAGRRLLAAVPLLAVVTFGVFALAAASPFDPAKAYAGTSGLSAGQDVLDRLRENLGADRPFVARWWDWLTAALTGDLGDSASLRQPVTQVIGERVGWSVLLGGVAFALAVTVGTALGVLAARRRGGLLDRTVTSLAYVLEAAPPFWLGLLAVWGFALKLDALPAGGLTDTGSDVVTAGQVASHLVLPAAVLAATQLPWFVLYVRQGVGDALTEDPVRGARARGLSERTVLLHHALRSGLLPVLTLLGSRVPELITGALLVETVFSWPGIASATVEAATKVDFPLLAALTVLATAAVLVGNLLSDLLYGLADPRVSHEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMW2</accession>
    <name>A0A2G1XMW2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07155</name>
        <name evidence="4" type="ORF">CYQ11_27310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52543">
        <property type="protein sequence ID" value="PHQ52543"/>
        <property type="gene ID" value="BLA24_07155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16081">
        <property type="protein sequence ID" value="PPT16081"/>
        <property type="gene ID" value="CYQ11_27310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="102"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="473" mass="51974" checksum="C2D63EE995B5751D" modified="2018-01-31" version="1">MTTSVEPDQSDQPTPAQPADTQLSLGTGAARQLATTTKSVPQMRGISSRWLLRVLPWVQVSAGTYRVNRRLVYTLGDGRVEFVSTGTEVRVIPAELGELPLLRDFGDTDTLEALANAFVQREYAAGDVLVEAGRPADEIFLIAHGKLTKTGPGEYGDETTLGILGDGDYFGDRAPLEPDATWGFTVRATTRCTVLSLSLQAFQELADRSEALRAHVDGFADRPTPPANKRGEADITVTSGHSGEPLIPGTFVDYELRPREYELSVAQTVLRVHTRVADLYNEPMNQLEQQLRLTIEALRERQEHEMVNNRDFGLLHNADLSQRIHTRSGPPTPDDLDELLSRRRKTQYLLAHPRTIAAFGRECSSRGLYPKNIEVMGTAVRSWRGVPLLPCNKIPISPTGTSSIIAMRTGEENQGVIGLHQTGIPDEYQPSLNVRFMGISEQAVSSYLVSAYYSAAVLVPDALGILEDVEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMY4</accession>
    <name>A0A2G1XMY4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07320</name>
        <name evidence="3" type="ORF">CYQ11_27475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52570">
        <property type="protein sequence ID" value="PHQ52570"/>
        <property type="gene ID" value="BLA24_07320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16108">
        <property type="protein sequence ID" value="PPT16108"/>
        <property type="gene ID" value="CYQ11_27475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="15210" checksum="945D04D671467F29" modified="2018-01-31" version="1">MTDTFHTRVLDISTGSTERVYDLTRDCEAYLREAAGGRDGLLNVFVPHATAGVAILETGSGSDDDLLAALHDLLPADDRWRHRHGSPGHGRDHVLPALVPPHATLPVIGGRLELGTWQSVCLVDTNVDNPDRKVRLTFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN29</accession>
    <name>A0A2G1XN29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-6A reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_06680</name>
        <name evidence="5" type="ORF">CYQ11_26830</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52613">
        <property type="protein sequence ID" value="PHQ52613"/>
        <property type="gene ID" value="BLA24_06680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16824">
        <property type="protein sequence ID" value="PPT16824"/>
        <property type="gene ID" value="CYQ11_26830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="252" mass="26181" checksum="D04D34351D6F6CE8" modified="2018-01-31" version="1">MVSGAERHVLILGGTTEARRLAAELAADPGLRVTSSLAGRVAEPRLPAGEVRIGGFGGPEGLAHWLREQQVAALIDATHPFAGTISFNAAQAAAAVHVPLLAVRRPGWVAGPGDRWHPVGSLAEAAGVLPALGGRAFLTTGRMGLAAFAHLEGMWFLVRSVDAPEPPVPARMEVVLERGPFTLEGERELLRRHAIDVLVTKDSGAAATSAKLIAAREAGIPVVVVRRPPAPDGVPVADGPAGAAEWLRRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN42</accession>
    <name>A0A2G1XN42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06105</name>
        <name evidence="4" type="ORF">CYQ11_03630</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52674">
        <property type="protein sequence ID" value="PHQ52674"/>
        <property type="gene ID" value="BLA24_06105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12108">
        <property type="protein sequence ID" value="PPT12108"/>
        <property type="gene ID" value="CYQ11_03630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="44854" checksum="AC9445EAAC2E3577" modified="2018-01-31" version="1">MTRVLTAGGFAEEQVRARARDGAAAAFPRREDYGRRLFGAEGTPRAGRPGDALESLRLVPPVFVPQRLEKLIELAREPHYGDVDLATTVGGFRSTAPLYVSAFGSTQVAASGLGTAVSRQAGRLGIPMVVGENIVPTVGYRGSDGESGMLARLSAYESEVPDGFGGVTFQQSTEDADAEVWNLLYSAPSAQKLLDSGRLAFELKVGQGAKPGLGGMTVVDTASAVRLAEHYTTDDVYGDGRHVLRSSSPGTFTEEILRQQIRLMRNNYPRARVWVKLPPGRDVRRAAAVAWEAGADAVTVDGAEGGSGWAPLSFLDHVGLPLGECLQRMRAWEERHCLLVSGRMWEGGRVARSLALGARAAGLGRAALLAVDENPDDGLDRLVSCLLLELRLLISALGKYAPGALGPEDVWAPDGTGTTPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNQ8</accession>
    <name>A0A2G1XNQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_05635</name>
        <name evidence="8" type="ORF">CYQ11_02095</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52821">
        <property type="protein sequence ID" value="PHQ52821"/>
        <property type="gene ID" value="BLA24_05635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11847">
        <property type="protein sequence ID" value="PPT11847"/>
        <property type="gene ID" value="CYQ11_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="38224" checksum="456301B7BB1158BE" modified="2018-01-31" version="1">MPTTATTGQPTVTPLGQQERKVLYAVGCGLRDEEIAAALAIPEGTVAGHLTRILTKLGLPDRAAAIVHAFDCGLVAPGHGPRRRTAGPVPRTAVRRPSGPRLRISVLGPLRACRDGRPVDLGHLRQQAVLANLVLCPGRTVSQQELLDGVWGMEPPATKVVPVYVYRLRKALHTGDGSDAVIERDRCGYRLLSAAVTVDVTRMEDLVSAAGQAERAGELAEAVRLCSRALELFRGEPLAGLPGPFAELERLRLTERRGVLAQRKLDWQLRLGEHTEAIAELWALAAAQPLNEPVAAMLMSALYRDGRQADALTVFDRARRRLAEDLGVPPGPVLLRTRQMILRGNAAGPGAIGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNT0</accession>
    <name>A0A2G1XNT0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04925</name>
        <name evidence="4" type="ORF">CYQ11_28605</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52904">
        <property type="protein sequence ID" value="PHQ52904"/>
        <property type="gene ID" value="BLA24_04925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11436">
        <property type="protein sequence ID" value="PPT11436"/>
        <property type="gene ID" value="CYQ11_28605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758524" evidence="2">
        <location>
            <begin position="34"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="525" mass="55428" checksum="BD33AF638A7808A4" modified="2018-01-31" version="1">MRDAVPARIRTTLARGVSGFIAVGLLWGSPARAQETGADTPAARSAAAQEAPLLDAASPVGERFRSSGRLVGGGGTTCTATLVHAPGKPDPRRKALILSNGHCVSDTMKTNEVTVDQPAGGDWTFTPAYFHDNASEHKTFPVEHVVYATMKDIDVSVLRISATYGELAKLNVTPRTLATAPPAPGTALHAVHAPTDGVEEGKRFLRLSTCRVTGSPVALHEYTWLWKGFARTDCLGISGGSSGGPVTAAGGDQLIAMLNTVATPGYLGCGLGRPCEGGAAGLTEPKDDTVYATPVDAVASCLENADLRLDRPGCRLDRGEQVDVASSGQHTRSETPQGPARWDAHVTPADARRHAYVAFKTGPFGATDCTRPEGYSTPRRLPRSGLDHTGLLPKEDNLYVLCAVGGPDATAHGKGWAASFAHPSSAYARVDNTPPSVAPKLDVQRFDHESGPVHWVRPVYAPWELTSYKIKYGPKAATDCADPQGYRPYVGVPTTLKVSEGPWTYCAIGYDNADNPTLPAAFTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNT3</accession>
    <name>A0A2G1XNT3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04725</name>
        <name evidence="4" type="ORF">CYQ11_28810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52873">
        <property type="protein sequence ID" value="PHQ52873"/>
        <property type="gene ID" value="BLA24_04725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11468">
        <property type="protein sequence ID" value="PPT11468"/>
        <property type="gene ID" value="CYQ11_28810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="436" mass="48484" checksum="305A54EE7927667B" modified="2018-01-31" version="1">MAGYPAGLGRCKYWSRETQSPAGAFAVAERRPTLAEHTTPARLYEAVEPPGLDFDPVFAELLRNEPLARLRLSHGEGECWLATRYEDVRLITSDPRFSRAAIVGRPFPKMTRHHIPMDKAVSFVDPPGHARVRGVIAGAFSHPSVERLRPRAQRILDGLLEELLRAGSPADLVERVTSPFPLTLISELIGIPPADRPLMREWAQVILGRASDDGAATRTSQVKADAGVYFRSLAARRRAEPRDDLMSVLAAAVEAGRLEEEELVALTGLMQFNGWHAVRNNTSNMMYILLTRPDLMHRLRTAPDLVRGAVEELLRYIPHKHGVGQPRIATEDVEVGSTLVRAGEVVYVSYVAANRDQRVYPKPDDIDFERRDAPHLAFGHGPHVCVAPMLARMESELLLSTLIERLPGLRLAVPADRIQWQTEILIRGPVALPVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW0</accession>
    <name>A0A2G1XNW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4243 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04900</name>
        <name evidence="2" type="ORF">CYQ11_28630</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52900">
        <property type="protein sequence ID" value="PHQ52900"/>
        <property type="gene ID" value="BLA24_04900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11440">
        <property type="protein sequence ID" value="PPT11440"/>
        <property type="gene ID" value="CYQ11_28630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="350" mass="37507" checksum="625377C9D5AA071C" modified="2018-01-31" version="1">MDTTSGTLDEALERLHASGPEFRGYLSNHGPMAVEALVRRGAARTVHPWLDAYRSRLEDVPAPKSRIGADDWREALGDPARVTDWTAYFTGQVAERPWRDVLAEWWPRLLPGIAGAAAHPVIRVGHAVRTLTQDGESEHRTGELAHALGYWAARHQLLPTAVNPSGDAAPHTALAALPRIADQHVLPTDGYAQLAGTPHWLETAESLHVPRTPDAIQEHLAALVRAATHNYALYGHGNPVMLVHAATAPNAVARVLPVLPEELWQQSLAVAWAATAAITSIYAADTPRPSPDAASLEPEEVFERAAAHGDEHVIKFADTALDVAASAEGGDPRALSAALNAVALIDADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW2</accession>
    <name>A0A2G1XNW2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4360 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04495</name>
        <name evidence="3" type="ORF">CYQ11_01755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52839">
        <property type="protein sequence ID" value="PHQ52839"/>
        <property type="gene ID" value="BLA24_04495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11788">
        <property type="protein sequence ID" value="PPT11788"/>
        <property type="gene ID" value="CYQ11_01755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304945" evidence="1">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="22294" checksum="00DB6AE109DA94FC" modified="2018-01-31" version="1">MFRPVLIGSASVALLATSFAPSAAAAGVPPPDRVVIDVVAVNGSGCPAGTAAVAVAADNRAFTVSYSSYLAQVGVGAKPTDFRKNCQLGLNIHVPQGYTYAIARADYRGFAHLEQGAAGLEKASYYFQGVSQTTSVSHRFSGPASDNWQTSDVTDVESLVYAPCGVQRILNVNTELRVGAGTSDPSTTNSFMAMDSTDGSVNTLYHFAWKECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP48</accession>
    <name>A0A2G1XP48_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5667 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_04155</name>
        <name evidence="5" type="ORF">CYQ11_14105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53018">
        <property type="protein sequence ID" value="PHQ53018"/>
        <property type="gene ID" value="BLA24_04155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13874">
        <property type="protein sequence ID" value="PPT13874"/>
        <property type="gene ID" value="CYQ11_14105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043725">
        <property type="entry name" value="DUF5667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18915">
        <property type="entry name" value="DUF5667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5667" evidence="3">
        <location>
            <begin position="136"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="40961" checksum="286895555D381370" modified="2018-01-31" version="1">MIANVSAHRRANAFAQALEDQEVQGAAAAQSSPSAAEAEQGRLLSLASGLGALPAPELDPEVKTVQRAQLIAAMEAQFAGGAAVPEQRSGRGAHRAGPLSRLRPRSRWSKGLAAGGLTVGVAAGAFGGVAAASSNALPGDTLYPVKRGMEDLKLGMADGDSARGRLFLDQASTRLQEARRLMERGRSGPLDHESVTEIRRTLSGMRHDAEEGHRLLHGVYERDGSLGAMRLLSSFTSSHREGWSRLREKLPVQLHDVGEQVTSVFAAIDDDVEPLRSLLHDKGGKHGSTNRPGASPQSSPGGHGGRSAPTPHAPSTADGKPSGKPSQSSTGGQGEREGLLGGTGLLQPPPSADGSGQDRSHGKDGKPSNKPDITIPPLLPDILPGLGIHGEDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP69</accession>
    <name>A0A2G1XP69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000064">
        <property type="protein sequence ID" value="PHQ53010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53010">
        <property type="protein sequence ID" value="PHQ53010"/>
        <property type="gene ID" value="BLA24_04275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013746761" evidence="2">
        <location>
            <begin position="29"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="202" mass="21647" checksum="D27963272E1A8262" modified="2018-01-31" version="1">MRHRAALPAVTALTALALALTAAPAAHAHGDTLKVEVTGQVQGHVTTDVTWENDNDPVDENVAATVNAVSPDGDRTVGPWKLQRDPAKAGRYTTAETLPAGQWKVTVEVGFPALGRGEKELTVDPAAEPRPFRPHRRRPRARARLRERAPAERGTGAAGWGTKGARARPRVDGEFFSPRPRAGKPTSTVTFHWPAGRVSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPG0</accession>
    <name>A0A2G1XPG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01870</name>
        <name evidence="1" type="ORF">BLA24_03365</name>
        <name evidence="3" type="ORF">CYQ11_16920</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000034">
        <property type="protein sequence ID" value="PHQ53350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53122">
        <property type="protein sequence ID" value="PHQ53122"/>
        <property type="gene ID" value="BLA24_03365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53350">
        <property type="protein sequence ID" value="PHQ53350"/>
        <property type="gene ID" value="BLA24_01870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14325">
        <property type="protein sequence ID" value="PPT14325"/>
        <property type="gene ID" value="CYQ11_16920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="66" mass="6985" checksum="519267B27A15937E" modified="2018-01-31" version="1">MCANPLWWDVTPVPGLAAGWYCSTCRHPPERCRNAAAAPPVCPEGCASSIVETASGGARKFICHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPI0</accession>
    <name>A0A2G1XPI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF969 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02015</name>
        <name evidence="3" type="ORF">CYQ11_04375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53144">
        <property type="protein sequence ID" value="PHQ53144"/>
        <property type="gene ID" value="BLA24_02015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12234">
        <property type="protein sequence ID" value="PPT12234"/>
        <property type="gene ID" value="CYQ11_04375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010374">
        <property type="entry name" value="DUF969"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06149">
        <property type="entry name" value="DUF969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="24679" checksum="EA87E584B752F756" modified="2018-01-31" version="1">MLVLLGVLVVVAGFATRRNPLLVVGAAGIVTGLLGGLSPREVLAAFGTGFAGSRAVTVFAITLPVIGLLERHGLQEQARNLITRFSGLTTGRFLALYLLLRQITAALGLGGVFGHAQTVRPLAAPMAEGAARGRHALTDKAREKVRSYAASADNVGFFFGEDVFLAVGSILLITGFVNTTYHTHLEPLDLALWAIPTALCALAVHGWRLLRLDRTLERALPGAPRSAPADEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPJ3</accession>
    <name>A0A2G1XPJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Polyprenol monophosphomannose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02135</name>
        <name evidence="3" type="ORF">CYQ11_04500</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53165">
        <property type="protein sequence ID" value="PHQ53165"/>
        <property type="gene ID" value="BLA24_02135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12256">
        <property type="protein sequence ID" value="PPT12256"/>
        <property type="gene ID" value="CYQ11_04500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="27907" checksum="B4A8A90E86818317" modified="2018-01-31" version="1">MTDAGQRRYGPLGTTLVIIPTYNEAENIKPIVARVREAVPEAHVLVADDNSPDGTGKLADELAAEDDHVKVLHRKGKEGLGAAYLAGFRWGLEHGYGVLVEMDADGSHQPEELPRLLTALAGADLVLGSRWVPGGRVVNWPRSREFLSRGGSTYSRLMLDVPIRDVTGGFRAFRRETLEGLGMEDVASQGYCFQVDLAWRAVKAGFHVVEVPITFVERELGDSKMSRDIVAEALWRVTSWGIGSRVGKALGRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT4</accession>
    <name>A0A2G1XPT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02790</name>
        <name evidence="6" type="ORF">CYQ11_05085</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53257">
        <property type="protein sequence ID" value="PHQ53257"/>
        <property type="gene ID" value="BLA24_02790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12350">
        <property type="protein sequence ID" value="PPT12350"/>
        <property type="gene ID" value="CYQ11_05085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="28906" checksum="605DE0D2BA85810F" modified="2018-01-31" version="1">MTTQRRAAVLGSPIAHSLSPVLHRAAYAELGLTEWTYDRFEVDEDGLCAFVEGLDDTWAGLSLTMPLKRAVIPLLDEISATAESVEAVNTVVLTEDGRRLGDNTDIPGITAALRERGIDKTDSAAVLGAGATASSALAALARVCTGEVTAYVRSAERAAEMRHWGERLGVSVRTADWSRAAEALTAPLVIATTPAGATDALAEAVPEHPGTLFDVLYEPWPTPLAAAWAHRGGTVLGGLDLLVHQAVLQVEQMTGRAPGPLAAMRAAGEAALAARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPW0</accession>
    <name>A0A2G1XPW0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxT</name>
        <name evidence="7" type="ORF">BLA24_02905</name>
        <name evidence="8" type="ORF">CYQ11_05200</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53278">
        <property type="protein sequence ID" value="PHQ53278"/>
        <property type="gene ID" value="BLA24_02905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12373">
        <property type="protein sequence ID" value="PPT12373"/>
        <property type="gene ID" value="CYQ11_05200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="20935" checksum="344B25BBE55EAE56" modified="2018-01-31" version="1">MSTPTIGVLALQGDVREHLVALASADALARPVRRPEELAEVDGLVIPGGESTTMSKLAVAFGMLEPLRERVRAGMPVYGTCAGMIMLADKLLDGREDQETLGGIDMIVRRNAFGRQNESFEASVEMAGVEGGPVEGVFIRAPWVESVGAQVEVVATYDGHTVAVRQGNVLATSFHPELTGDHRVHALFVDMVRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQA7</accession>
    <name>A0A2G1XQA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_01295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000018">
        <property type="protein sequence ID" value="PHQ53403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53403">
        <property type="protein sequence ID" value="PHQ53403"/>
        <property type="gene ID" value="BLA24_01295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="62" mass="6884" checksum="03789B83C6EF03AF" modified="2018-01-31" version="1">MAYQPSRLLGALPHQVGGSPHLEAGFPLRCFQRLSLPNVANQPCPWQDNWHTRGSSVPVLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQC5</accession>
    <name>A0A2G1XQC5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00490</name>
        <name evidence="2" type="ORF">CYQ11_07500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53447">
        <property type="protein sequence ID" value="PHQ53447"/>
        <property type="gene ID" value="BLA24_00490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12752">
        <property type="protein sequence ID" value="PPT12752"/>
        <property type="gene ID" value="CYQ11_07500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="8344" checksum="E04D28D608CD5766" modified="2018-01-31" version="1">MNAAPEAGTWVVDVRRDRVGEVVEVSDGRVSLRDLTSREEWEALSCDVRPATANDELRAKVADLNHRSVRRQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQD3</accession>
    <name>A0A2G1XQD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2334 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00410</name>
        <name evidence="3" type="ORF">CYQ11_07420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53432">
        <property type="protein sequence ID" value="PHQ53432"/>
        <property type="gene ID" value="BLA24_00410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12736">
        <property type="protein sequence ID" value="PPT12736"/>
        <property type="gene ID" value="CYQ11_07420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018763">
        <property type="entry name" value="DUF2334"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10096">
        <property type="entry name" value="DUF2334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304886" evidence="1">
        <location>
            <begin position="36"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="608" mass="64576" checksum="8EF4A70444A74841" modified="2018-01-31" version="1">MNEMRGRSGASRISLILVLVAALLGGVSLSTGAEAAIAVKKPSPPHGLTGVGSASLSGVGTTDLKSWVSSRLQADVQRRAGKLTVSPAPLTAAAAAAPLAAPTGTSALVLYDTTGPYGYLGELYAMAVANLAGHFGTVTSKPVSAYTAGLVDQYTATVYIGSTYYGGSIPDAVPAVFYQDALKTTKPVSWVGDNIWNMANAVGIEAFKQKYGWDPTNSFFETGGSVGNITQVAYKNQTLTRKIPTGFDGGVLHPALSGAGYPQVTELATATDANSGATSPWAVRSGNLTYVGEIPFTYVSESDRVIAFEDLLFDGLAPATTERHRAFVRLEDISPKADPAQLRAMADYLYSQKIPYGINVIPVYKDPKGVYNGGRAETVTLAQAPKVVTELKYMLAHGAVLMNHGYTHQYNNVNNPYTGVTGDDFEFFRAHVDAADNVIYDGPPAEDSTLWAQSRVTSALGAFAAAGLPKPTLWTTPHYAASATDYRVLGQNYTARLERSLYFAGTLSGGAVNASRYIGQFFPYAVKDVYGTTVLPENIGNYEPEPFNNHPARLPADLIASAKANLAVRDGVASFFYHPYYAVDPLKQTVDGIRALGYTFVGPTELAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQS8</accession>
    <name>A0A2G1XQS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00990</name>
        <name evidence="2" type="ORF">CYQ11_08000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53572">
        <property type="protein sequence ID" value="PHQ53572"/>
        <property type="gene ID" value="BLA24_00990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16421">
        <property type="protein sequence ID" value="PPT16421"/>
        <property type="gene ID" value="CYQ11_08000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="391" mass="41589" checksum="EF97543A4DFAA933" modified="2018-01-31" version="1">MTGCDVSGGGDRGDHGRAAAERLLKRWSAAVRDRDESAYLAAVDPAAEGYRAERRRVFASLASVPLASWEYRLVRTGGFAPAAGDGRRLAAQVELRYRLAGYDSAPVSAALRLTLVRRDGGWYVAGQDAGGGGAQLWEQGEVTVVRGRRGIVLGVGQDPQRLRAVADLVDRAVPDVDGAWRGPWAERVVVEMPASLDRMAALLGAPAANYRGIAAVTTGEVGGGPAAPADRIIVNPEAYGALGDFGRRIVLTHETAHVATRARTSAATPLWLSEGFADWAAYRATGRTARQAAPELAAALEAGSAPRELPEDADFGFTGEAGRLARAYEGGWLACRMIAERWGEERLVAFYAAVGARKKRAGAVDGALREVLGVSAGEFTQQWRRYVTDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQS9</accession>
    <name>A0A2G1XQS9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00835</name>
        <name evidence="3" type="ORF">CYQ11_07845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53509">
        <property type="protein sequence ID" value="PHQ53509"/>
        <property type="gene ID" value="BLA24_00835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12814">
        <property type="protein sequence ID" value="PPT12814"/>
        <property type="gene ID" value="CYQ11_07845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="500" mass="52117" checksum="5BF1A8F91B6C7F63" modified="2018-01-31" version="1">MARIAVIGAGMGAMAAAARLAVAGHRVAVYERAATHGGSVGRLERDGFAFDTGPGLLHLPAVYRDLFVKTGKESLEQSLTLTQVDPASRHLFADGTDVRLPNASRAGVVAALDAAAGPGAGERWSDLVNRAREVWDATRRPLLEEPLRADRTAALGHDPYPAPPRRGLFRRRRGPLTLASVAERELADPRLVALLEGHALAHGLDPRVAPASATVLPYMEQTFGSWYVRGGVRALADALYERCLARRVEFFFGAEVVGLVEEDGRAAGVRLAGDGVAEADMVVAGVAPGRLEAFAPGVAGPSRGPVPPGRFSVFLAVAGSRPEDAAHRTVVHGDDRTAELEAVFGAAGVGGYRPTVTVLRPDDADTRPDDAHEAVTLTATIAPHGRTDWNDARTVADFADRMVAAAEAAVPGLRERVLWREVRTPADTEAATGAEGGGVPAPVLAGGEGAFLRPANVTRLPGLYLVGGFAHPGGGLAHAGMSGAMVAGLIVEGADWRGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9G8</accession>
    <name>A0A2G1X9G8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30665</name>
        <name evidence="3" type="ORF">CYQ11_23760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47872">
        <property type="protein sequence ID" value="PHQ47872"/>
        <property type="gene ID" value="BLA24_30665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15497">
        <property type="protein sequence ID" value="PPT15497"/>
        <property type="gene ID" value="CYQ11_23760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="273" mass="28770" checksum="23F0C9C8A38C9B84" modified="2018-01-31" version="1">MAGSTPFRKRRSRQPEPTNGLAEGASGGQAGTAPGRNVERGRRASLASAVGRGAGWAGDTVMKGGRGARAGLTVVADRIVVNAPRIPVRDLATLRAQFPGLGPEELADKLVAGAVHGTSTVGAGIGAAAMLPVPPAIPAELAAEIIGVAAVEFKMIAELHEVYGRRAPGTVRQRATAYLGAWAEERGIDVTSPMTVNAALGGQLRRELRQRVLKRTFRSLPNVAPFMIGATVGAMINRRDTRRLAERVRRDLRSRQVAWDDLPESPDEGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9P4</accession>
    <name>A0A2G1X9P4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_31325</name>
        <name evidence="10" type="ORF">CYQ11_24365</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47957">
        <property type="protein sequence ID" value="PHQ47957"/>
        <property type="gene ID" value="BLA24_31325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15581">
        <property type="protein sequence ID" value="PPT15581"/>
        <property type="gene ID" value="CYQ11_24365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="119"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ47957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="39819" checksum="0F3660ED06521010" modified="2018-01-31" version="1">MTTPFALDRTQHTWCAELRDLAARRLRPLAEKGEPGHVNRPLVAALGELGLLARALPVEGPARAMDLCLLRLSLAQECTEAETALALQGLGAHPVARSGTPDQRARWLPDVVAGRAVAAFALSEPGAGSDAAALELLAEPAGPGPRGGGGWRLTGEKCWISNAPEADVYTVFARTGQAPGAAGVTAFLVPADRPGLSGRPLEMLSPHPVGTLAFDAVPVGPDDVVGEVGGGFRVAMTTLDLFRPSVGAFAVGMARAALDAALLHASERQAFGGPLKDLQAVSHQLAEMATRTEAAALLVLAAASAYDAGEPGVARRSAMAKLFATETAQYVVDAAVQIHGARALRRGHLLEHLYREVRAPRVYEGASEVQRTIIARELYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9R7</accession>
    <name>A0A2G1X9R7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PaaX family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31315</name>
        <name evidence="4" type="ORF">CYQ11_24355</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47955">
        <property type="protein sequence ID" value="PHQ47955"/>
        <property type="gene ID" value="BLA24_31315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15579">
        <property type="protein sequence ID" value="PPT15579"/>
        <property type="gene ID" value="CYQ11_24355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="179"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="30866" checksum="87F77CE7F3430ACF" modified="2018-01-31" version="1">MTDQQPPHTPRSLIVTFYGAYGRGTAGTPAGPVPIAALIRLLGAVGVDSPSVRSAVSRLKRRGLLVSGRTADGAAGYGLSEAARQLLDDGDRRIYGRPATRPGQGWLLAVFSVPEQERHKRHLLRSRLARLGFGTAAPGVWIAPAHVHEETRHTLERLGLDTYVDLFRGRHLGFEPTTESVARWWDLDALARQHRAFLETHEPVLRRWSRRRPVPPEAAYRDYLLALDSWRRLPYADPWLPTALLPADWPGGRAARVFAALHARLRDAGAHFVTMGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9S9</accession>
    <name>A0A2G1X9S9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31460</name>
        <name evidence="2" type="ORF">CYQ11_24505</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47978">
        <property type="protein sequence ID" value="PHQ47978"/>
        <property type="gene ID" value="BLA24_31460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15603">
        <property type="protein sequence ID" value="PPT15603"/>
        <property type="gene ID" value="CYQ11_24505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="94" mass="10739" checksum="1162F53E70B9C903" modified="2018-01-31" version="1">MAEEPIAIKLTRDQALVLSDWLYQAMHRSDVLDDLLKTDRAVWSPIYAISGTLERTLTEIFTPDYDERMKAARQRLLVEMYGSDDEAETGETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA24</accession>
    <name>A0A2G1XA24_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_31930</name>
        <name evidence="8" type="ORF">CYQ11_24985</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48061">
        <property type="protein sequence ID" value="PHQ48061"/>
        <property type="gene ID" value="BLA24_31930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15687">
        <property type="protein sequence ID" value="PPT15687"/>
        <property type="gene ID" value="CYQ11_24985"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="504"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="584" mass="62109" checksum="CBF1253D908B2E0F" modified="2018-01-31" version="1">MTAPTLLDRFARQVADHPDAVALRHTGTSLTYRELDEWAGRLAARLAAKGTGPGSLVALAADRGPAAVAGVLAVLKTGAAYLGLDPATPVRRQRRMIEEAGPHVVLAEPGLDRFPTLDVPRVRLVPLTEGPLHPGPAREPDEDDLFHIVYTSGTTGNPKGVRISRRSVRNRLEWMWRDHPFTEGAVLAVQKSVALVASPWELLGGLLQGVPSVVLGSDEVLDPALFAAAVAREAITHLYVTPQLLAGLLEESAALAGGHQPVLVTSGADALPVSVVRRFREVWPAATLLNLYGMTETASNVGAYDTAALPDDAERVPVGRAVAGAVLSVRDRLGRRLPAGAPGEVWVSGPPLALGYLGGDDGDRFTTDASGTRHYRTGDRGRLLPDGALEITGRTDNQVKVRGYRVELEEVESTLRKAPGVTDAGAYADREEGETRIVACVTAGEELDVPALRAHLRDRLPDYMLPARVEQVPRLPLGTNGKLDRAALRDVVASTRARRGSDFAPADATEAAVAALWRELLGAPPATADENFFDAGGHSLLAVRLAGRLEATAGRRVPLRRILGAPTVRGIAAVCHEVRKEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA88</accession>
    <name>A0A2G1XA88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32390</name>
        <name evidence="3" type="ORF">CYQ11_25440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48132">
        <property type="protein sequence ID" value="PHQ48132"/>
        <property type="gene ID" value="BLA24_32390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15758">
        <property type="protein sequence ID" value="PPT15758"/>
        <property type="gene ID" value="CYQ11_25440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="28347" checksum="A15EC7809068FE20" modified="2018-01-31" version="1">MGDSRPVYLRIADDLRRRIDEGGLAVGERIPSRSELKRTYAASDQTVDRAVRVLKAAGYAEGQFGRGVFVTDRAPLGSLLRSTGAVDSPFAAEVLGYGARPAGAGERPGKGRETALTWEASSSETPAPAPIAERLGIDAGEPVLCTQYEYLANRHPVQLATSWEPLTITEGTDVVLPERGPYARRGVRGRLAAIGIRVVRARELVGSRPATTPEAEALGCTAGQCVTVVERTHFDGDDRAVETSDIVVRADRWRLEYSIPFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAE5</accession>
    <name>A0A2G1XAE5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32830</name>
        <name evidence="4" type="ORF">CYQ11_25880</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48206">
        <property type="protein sequence ID" value="PHQ48206"/>
        <property type="gene ID" value="BLA24_32830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15832">
        <property type="protein sequence ID" value="PPT15832"/>
        <property type="gene ID" value="CYQ11_25880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="33"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="542" mass="58779" checksum="36C986B02647469E" modified="2018-01-31" version="1">MEGRGLARRRPGAGTARGTATGGETPVDDIRKADVVVVGAGPTGLAVAVGLRQHGVDVAVVEKAALGKREARAGIIWQRALEVLADLGCAREMTAEGIKLRRVEVFAEGRRAWRMGMECAGTAFPNPLSIEQDAVERLLGERLVALGGRVEWSTEAVAVRTGGDGAEVDVRTGDGGLTTLRCAWVIGCEGAHSVVRKGLGIPFEGGRRPDLQCVQLNAVPDWKVPYRPGHTYFFLERGLSMGVSPRPGGGYRFFAFLTDPDPTVEGPPGVEEMRDLVARSAHEPGVRLAPTDPPWANRARFQDRVAATLREGRALLAGDSAHLWAPIGGHGLNTGLRGAHNLAWKVAAAVRGWAADPFALLDTYSTEQRLTAEKVMREMRHNLLELPPTALALRGMRLVGGPVMSTPWASGRIRSMLSDLTMHHRESALSQGGGGDRLPDPFVRVRGRHCRLHDLLSYQRWTLLAAPGAKGPGMTDDHLRALVAGYRAPVDILRPRTDPDTVPRLPGKALVLVRPDRHIGLRTDRVEELEAYLRRWFARDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAM4</accession>
    <name>A0A2G1XAM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_33165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48261">
        <property type="protein sequence ID" value="PHQ48261"/>
        <property type="gene ID" value="BLA24_33165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028908">
        <property type="entry name" value="Tox-PL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15644">
        <property type="entry name" value="Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="1999" mass="212572" checksum="EB9AE0BA7DE3410C" modified="2018-01-31" version="1">MTLAQRKAQVHGSQGSYSPMREFLKPRRQRLPAEPAPKPDKPLKVGPAAKSLKGPAARAAAAGVPNPDWVSAYATAYPGMLSIGGQAKFSSVSASAVSGLWLYVMDENKNPVHQQEIKRSTGDPEGKYLENGAWCYGWWPSNPYPADQCFWWSSSLNGGHLQDGKKYYAWIFLEGTDGSGSPGGMTSPFVQAFYTPDIPGTQAGLCHCYGQTRRADPVNTATGAFYDRNTDASLVGVGTPFSMERTYRSDSAESGLLGRGWATSFDAKLTITAGSSATLQDADGARVAFKEQGGSSYATPAGSSLQLTKSGTTYIVASPDGTRRTFSSSGQLTSVASGGGAALTLTYSSGRLASVKDGAGRSVPFTLDASGLLTRMTLPDGTSVSYGYTDGLLTSVKDQVGKTTTYTYDSNKRLSTATGRGGGKVANTYDASGRVVSQTDGSGKTSTFTWDNKRESHMTDPNGGVWTDVYSGNVLLESINPYGDKVSYSYDRNLHPVSITDPSGNTTEMSYDTAGRLSTRKSPSSVGLAETWTYDAQGNISSHTDGRGKRSTYTYDTANRVTFSTDPAGGTVAYTYTDQGALASVTTPRGKATIYTYDAAGNRTSVTTPLGEKTTFRYDAAGRVTAMTDPRGNAEGADPAAFTTTYTYDGRGLLLSATDPLRHTTAYGYDGAGRLLSVKDPAGRITAYAYDSSGRLVETTNPAGKKQTRAYDANGNLTSVTDALGNRTTYTYDKANWLISTVSPRGNILGANAAAYTTSYGYDANGNRTKVTDPTGAVTTTAYDALGRQVSVTNALGQTSSTTYDANDNVLTSTDPLGNVTHHSYTDTGLLATSTDPLGKVTSFGYDADGHRTRMISPEGRTTTWSYDDDGRTATQVDPRGNVSDAEAAQFTTSFGYDAAGNQTKVTNPLGKSTSTAYDATNRAVSTTDELGRTTKTDYDDLGRIAAVTGPDGAVTRYTYNTAGDLATRKDPNGHTTTYEYDETGRQTSVTDPLGRRKTYGYDVDGNRITVTNARGVTARTDFDARGLPRGTTYTDNTPTVTTAYDAIGQRRSITDGSGTRTLDYDSAGRLTAVTPSTGKAVFSYAYDDMGRITERTSDIGSAGPTGAVVGVNGLCVDVDNGQTKDGTVIQSWTCAGVPAQQWTYDGAHLKALGKCAAATGSGRGAQVKLATCSNDALQRWTFRDNGELVNAAGGKCMEISNGTNKLGTPITTWDCLAAAWHHWTLPRPTGAVVGVNGLCVDVDNGQTKDGTVIQSWTCAGVPAQQWTYDGVRLKALGKCAAATSSNKGAQVKLATCSDDALQRWTFRDDGTLVNAAGGKCMEISDGTNKLGTPITTWDCLDVAWHHWTLPRSGIASNTIRYAYDGDGLRTSETTAAGTIAYSYDQDGHLTTSKLPAANSYVEKRAYDNAGHLTSVSNVKGASALSTWAQTLDDAGQPVQIEVTRAGKAASYQYYDYDPAGRLTTECSSVAKADKCPDLSAATTYRYDQVGNRQLQNRAGVSTTYKYDDADQLIQSVSGSASRDFTYDADGNQTGAGGDTFAYDANNRLIKAVAGGAAYSYGYDADGNRTTASKDGGGLQRTTAWDINNALPLAAADYDGNGTLQAEYRYTPRGQIQAEATGGNTYYHHRDLLGSVSDLTDSNGNLQTSYTYTAFGEGTQTNAGGKPPANPFAFAGAYREPTTSAAGYYLRARNYDPATGRLTGTDPAPAPVGEPYASAYPYAANAPTRYTDPTGWTPDDPNDDHIKSFSEGARVFGSGFVEGLKLPFKFVGDLFNALRGKNGGTGGFVDEYLPVRPAYRLYHAAEMFRDQGCDELHDTYSRAADDLAMQIAATGLGGLRGWKKDAVTPPAGGRYYGGRSETRYGLPYYTPEHLPSMERINPEGGRMNCGLCATAGDDLMAGKNPNAVPGADRPMRPDEVSALTGRPFVRKGGLDPLVRDVLSWGPGARGIVGAWPTRGMGHYFNVVNADGKVVFFDFQTGRANPADQRYRNYYLMRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAR1</accession>
    <name>A0A2G1XAR1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_33455</name>
        <name evidence="13" type="ORF">CYQ11_26505</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48310">
        <property type="protein sequence ID" value="PHQ48310"/>
        <property type="gene ID" value="BLA24_33455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15941">
        <property type="protein sequence ID" value="PPT15941"/>
        <property type="gene ID" value="CYQ11_26505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304540" description="Histidine kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="244"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="465" mass="48991" checksum="0ABAD4051F80F359" modified="2018-01-31" version="1">MRWALVKVSLAVTVMVVLAFAVPLGLVVKELARDRAFTDAERQAAQIRPALAITTDRAQLERAVASSQAGEVGRLAVHVPPTGDAPAPGGANAEAHEAYDVGRSRADPRHVETARRGRSVITAVPGGYALLQPTALNAGEFAVVEVYVPHDAVDNGVTTSWLVLAGVGLALVAGSVATADRLGLRLVRPAERLARAAVQLGEGRLDVRVREDGPAELRAAAVAFNSMADDIVQLLTSERELAADLSHRLRTPLTVLRLNAASLGDGPVAEQTRTAVAQLENEVDQLIRAAREDRRQKPQPTLGCDACEVIRDRMGFWSALAEDEGRTVRLAGVDATARVPVARGELAAALDAMLGNVFRHTPEGTAFAVDVHHSKDAVIVLVSDAGPGIADPGAALRRGHGAGGAGSTGLGLDIVRRVAESTGGDVRIGRSVLGGAEVRVWLSAEGTGPRRRTGRRRVRRGRTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAW8</accession>
    <name>A0A2G1XAW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31940</name>
        <name evidence="2" type="ORF">CYQ11_24995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48352">
        <property type="protein sequence ID" value="PHQ48352"/>
        <property type="gene ID" value="BLA24_31940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16778">
        <property type="protein sequence ID" value="PPT16778"/>
        <property type="gene ID" value="CYQ11_24995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="72" mass="7107" checksum="C76A6CAE0B50825A" modified="2018-01-31" version="1">MRNDIETREIADAELDAVSGGVSISGGLLGGVTGDVHTVLGTVTNLQTVQAVRPTVGAVEGLVGVHVGVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB70</accession>
    <name>A0A2G1XB70_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 2 glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29280</name>
        <name evidence="3" type="ORF">CYQ11_06195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48462">
        <property type="protein sequence ID" value="PHQ48462"/>
        <property type="gene ID" value="BLA24_29280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12543">
        <property type="protein sequence ID" value="PPT12543"/>
        <property type="gene ID" value="CYQ11_06195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="346" mass="36171" checksum="0B95B1B3C30C2D6F" modified="2018-01-31" version="1">MSAAPTGRTGAPSVSVVVCVYTEDRWGDILAAVASVCDQSHPALETLLVVDHNPGLLRRLAKAFGDDGAGAHRVRVLPNAGPRGLSAGRNTGIAASSGEVIAFLDDDAVAERDWLLHFAEAYADPRVMAVGGRTQPVWASRRRPAWFPEEFDWVVGCTYRGLPPGRVPVRNVLGGNASFRRTALAAVGGFASGIGRDGHRLPLGCEETELCIRLARAVPDAVLLIDDRSVIHHRVPAARERFGYFRTRAYAEGLSKALVAHIVGAQDGLASERRYTTRVLPAGVARGVRDALLGRPGGAGRAGAIVAGVAAAAGGYVLGTWRARRTGGRFAVASLPAAAPGEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBE7</accession>
    <name>A0A2G1XBE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29645</name>
        <name evidence="4" type="ORF">CYQ11_05830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48521">
        <property type="protein sequence ID" value="PHQ48521"/>
        <property type="gene ID" value="BLA24_29645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12480">
        <property type="protein sequence ID" value="PPT12480"/>
        <property type="gene ID" value="CYQ11_05830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304818" evidence="2">
        <location>
            <begin position="45"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="18868" checksum="C6F3329A0BFF42A6" modified="2018-01-31" version="1">MHPTAGPSAYPHTRPRPVHWLATAAALAAVVTGAALAGPGDATATTPTTHAAAPDPQTAHYPLDCHGAGPQVTDRAQADLDGDGRPETAVAVRCASGGGTPPSGVYVLASPHPDGTAPRIRATLVDPRQRMTVTGLTAAKDTVSATVSGYSGPGVPRCCPDLRTAVKWRWTGGKFTVTTPPVARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBJ9</accession>
    <name>A0A2G1XBJ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MBL fold metallo-hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04060</name>
        <name evidence="4" type="ORF">BLA24_04070</name>
        <name evidence="2" type="ORF">BLA24_28305</name>
        <name evidence="5" type="ORF">CYQ11_07165</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000061">
        <property type="protein sequence ID" value="PHQ53043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000061">
        <property type="protein sequence ID" value="PHQ53044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48624">
        <property type="protein sequence ID" value="PHQ48624"/>
        <property type="gene ID" value="BLA24_28305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53043">
        <property type="protein sequence ID" value="PHQ53043"/>
        <property type="gene ID" value="BLA24_04060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53044">
        <property type="protein sequence ID" value="PHQ53044"/>
        <property type="gene ID" value="BLA24_04070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12696">
        <property type="protein sequence ID" value="PPT12696"/>
        <property type="gene ID" value="CYQ11_07165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="218" mass="23358" checksum="5EC84F78907B4A33" modified="2018-01-31" version="1">MTYSGAVQVGGPADVHELTDLMISKVAVGPMNNNAYLLRCRATDEQLLIDAAAEPHTLLSLIGDSGITSVVTTHQHADHWGALREVVAATGARTYAGKYDAEGIPVGTDELVEDGDVIRVGRVELTARHLVGHTPGSIALVYDDPHGHPHLFTGDCLFPGGVGNTHDDPEAFASLLGDVETKLFGQLPDETWVYPGHGDDTTLGAERPHLAEWRKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBS3</accession>
    <name>A0A2G1XBS3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28670</name>
        <name evidence="2" type="ORF">CYQ11_06795</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48683">
        <property type="protein sequence ID" value="PHQ48683"/>
        <property type="gene ID" value="BLA24_28670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12636">
        <property type="protein sequence ID" value="PPT12636"/>
        <property type="gene ID" value="CYQ11_06795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="111" mass="11975" checksum="16441E792EBB2FA8" modified="2018-01-31" version="1">MEPAERGATRIADRVVAKIASRAAGEALSDTAEEHHEPPLASVVVHEGAARIRVAVELGYPGDIGARCRAVRSRVAERVRGLAGMDVPEVVITVERLHSPHTGRADRERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC01</accession>
    <name>A0A2G1XC01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12480</name>
        <name evidence="4" type="ORF">BLA24_28085</name>
        <name evidence="2" type="ORF">BLA24_28100</name>
        <name evidence="3" type="ORF">BLA24_28115</name>
        <name evidence="6" type="ORF">CYQ11_17555</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000157">
        <property type="protein sequence ID" value="PHQ48750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000157">
        <property type="protein sequence ID" value="PHQ48752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48750">
        <property type="protein sequence ID" value="PHQ48750"/>
        <property type="gene ID" value="BLA24_28100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48752">
        <property type="protein sequence ID" value="PHQ48752"/>
        <property type="gene ID" value="BLA24_28115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48919">
        <property type="protein sequence ID" value="PHQ48919"/>
        <property type="gene ID" value="BLA24_28085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51644">
        <property type="protein sequence ID" value="PHQ51644"/>
        <property type="gene ID" value="BLA24_12480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14432">
        <property type="protein sequence ID" value="PPT14432"/>
        <property type="gene ID" value="CYQ11_17555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="148" mass="15984" checksum="2C961ACF8584D94E" modified="2018-01-31" version="1">MATSPSGDSLDNAALQRRITPGMLVAALSVPLLTVAGPAASLHSEDIENDWAHRQQDACRHMPFPNAEYVAAWAGLALGLAAVVVGVVLIKRIRRQYRDRLGDSWPAILTYISVFLFLCLNVLAVPMELIMVYVTHSNAGSLVNLGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCC8</accession>
    <name>A0A2G1XCC8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27905</name>
        <name evidence="3" type="ORF">CYQ11_17735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48886">
        <property type="protein sequence ID" value="PHQ48886"/>
        <property type="gene ID" value="BLA24_27905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14466">
        <property type="protein sequence ID" value="PPT14466"/>
        <property type="gene ID" value="CYQ11_17735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015066">
        <property type="term" value="F:alpha-amylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036379">
        <property type="entry name" value="A-amylase_inhib_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758464" evidence="1">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="118" mass="12450" checksum="F3A27BBED78D973F" modified="2018-01-31" version="1">MIFIKGVTMRARKPLAAGALTAAAAIAATGLLAPTASAADTKTPPSCVTAKYTWGWVPKATVTNNCAGDQAKTYNVKVKWLIGYETYRTSECFAVAPNESKETSGHYETDTIAALESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCI5</accession>
    <name>A0A2G1XCI5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27110</name>
        <name evidence="4" type="ORF">CYQ11_18530</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000155">
        <property type="protein sequence ID" value="PHQ48946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48946">
        <property type="protein sequence ID" value="PHQ48946"/>
        <property type="gene ID" value="BLA24_27110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14597">
        <property type="protein sequence ID" value="PPT14597"/>
        <property type="gene ID" value="CYQ11_18530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="20846" checksum="93AC2A3085652E5E" modified="2018-01-31" version="1">MGNREDLLAGAKHCLRERGYARTTVRDIASAAGIGMAAIGYHFGSREALLNAALLQALDDWSEEIGRAVAAAADAEATAGERYEAVWSEVVRTFSTHRPLWLASVEAFVQAEHAPELRRQIAAGHTEGRRVLAAQLLGTPQEDVPDGTAHTLGTVLLALLQGVMMQSLADPGRAPSATDVAEGLRALTAVLDPAGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCK0</accession>
    <name>A0A2G1XCK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoaD/ThiS family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27920</name>
        <name evidence="2" type="ORF">CYQ11_17720</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48889">
        <property type="protein sequence ID" value="PHQ48889"/>
        <property type="gene ID" value="BLA24_27920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14463">
        <property type="protein sequence ID" value="PPT14463"/>
        <property type="gene ID" value="CYQ11_17720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="91" mass="9451" checksum="31CF341160D3B0D8" modified="2018-01-31" version="1">MSVNVRIPTILRTYTSGRAEVTVEGATLAEVIASLEAGHPGIAARVLDDSGKLRRFVNVYVNDDDVRFEGGLETPTPDGAGVSIIPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCW3</accession>
    <name>A0A2G1XCW3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavodoxin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23405</name>
        <name evidence="3" type="ORF">CYQ11_22665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49041">
        <property type="protein sequence ID" value="PHQ49041"/>
        <property type="gene ID" value="BLA24_23405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15313">
        <property type="protein sequence ID" value="PPT15313"/>
        <property type="gene ID" value="CYQ11_22665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="20520" checksum="9F9820BF46FE7A84" modified="2018-01-31" version="1">MVTTPVVSIAYHSGFGHTAVLAEAVRSGAAGNGATVHLINVAEITDAEWELLDGSDAIVFGSPTYMGTASGAFHVFAEATSKRWFTRAWQDKIAAGFTNSASKSGDKLHTLQFFTVLAAQHGMHWVGLGTMPGWNSSTASENDVNRLGFFLGAGAQTNNDQGPEGVHKADIATAELLGRRVAEQARVYVAGRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ9</accession>
    <name>A0A2G1XCZ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">BLA24_23910</name>
        <name evidence="11" type="ORF">CYQ11_22160</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49124">
        <property type="protein sequence ID" value="PHQ49124"/>
        <property type="gene ID" value="BLA24_23910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15228">
        <property type="protein sequence ID" value="PPT15228"/>
        <property type="gene ID" value="CYQ11_22160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="420" mass="45050" checksum="2F563B4048E10A29" modified="2018-01-31" version="1">MSLLNSSLHELDPDVAAAVDAELHRQQSTLEMIASENFAPVAVMEAQGSVLTNKYAEGYPGRRYYGGCEHVDVVEQIAIDRIKALFGAEAANVQPHSGAQANAAAMFALLNPGDTILGLNLAHGGHLTHGMKINFSGKLYNVVAYHVDEQTNRVDMEEVERLAKEHRPKLIVAGWSAYPRQLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPSPVPHAHVVTTTTHKTLGGPRGGVILSTADLAKKINSAVFPGQQGGPLEHVIAAKAVSFKVAASEEFKERQQRTLEGAKILAERLVQPDVAEAGVSVLSGGTDVHLVLVDLRNSELDGQQAEDRLHEVGITVNRNAIPNDPRPPMITSGLRIGTPALATRGFQTEDFREVADIIAEALKPGFDAEALRGRVTALAAKHPLYPGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD03</accession>
    <name>A0A2G1XD03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-(3-hydroxyphenyl)propionate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23640</name>
        <name evidence="3" type="ORF">CYQ11_22430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49081">
        <property type="protein sequence ID" value="PHQ49081"/>
        <property type="gene ID" value="BLA24_23640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15273">
        <property type="protein sequence ID" value="PPT15273"/>
        <property type="gene ID" value="CYQ11_22430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="502" mass="53996" checksum="40FF5132DFFE78EA" modified="2018-01-31" version="1">MTDTAVLIVGAGPTGLTLACTLARSGVDVRIIDKSSRFHQASRGKGLNQRSRELFDDLGVGERAAAAGTEHITLRKYRDGKHVADSVSFADRVPTPDTPYASGLLIPQWRTEEILREKLAEYGVHVELGCELAGFDQDEDGVTARLADGRSIRAAYLAGCDGGHSPVRKALGLRFDGKTDAEECMVVGDVRADGLDPRYWHQWFDEDAALLLCPFPGTAHWQLQGMPERDADGRPTAPTLESFQRLFDRCARIPGIRLADPTWFSTYRVNVRMADRFRVGRVFLAGDAAHVHSIAGGLGMNTGVQDAFNLGWKLAFVVRGMAAPGLLDTYEEERLPVAAWTLDLTDERLRAVVEGVREAGVGTEAVITDDVTTLGVGYEWSTLSHGGPLAGRRAPDAPCRDAATGTPVRLFEVFAGPHFTLLGFGAGGAEALERTGAAHGEGVRARLIDDHEGHARAAYGLEGDALVLVRPDNHVAMSVPADRAADVVSYLQRLGAPDPSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDD3</accession>
    <name>A0A2G1XDD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24350</name>
        <name evidence="4" type="ORF">CYQ11_21720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49201">
        <property type="protein sequence ID" value="PHQ49201"/>
        <property type="gene ID" value="BLA24_24350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15149">
        <property type="protein sequence ID" value="PPT15149"/>
        <property type="gene ID" value="CYQ11_21720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="208" mass="22908" checksum="2A4E6CDEE6FB2159" modified="2018-01-31" version="1">MTEGLRERKKRQTRQHLSDVATGLFLERGFDAVTIAEVAAAADVSVNTVYNYFPAKEDLFLDREDDAVGWLAAVVRGRPAGESAARAVLRALRAETVAVSPRLGLVDGYDRFMRVIGESQALRSRVLDMRRRATEALTAVLAQERGDDDLLPELVASQLGWIQSHVVEFVQRELTAGRSAAETSRAVLVLLDEIEDLLSEKLLAYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDR0</accession>
    <name>A0A2G1XDR0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25295</name>
        <name evidence="2" type="ORF">CYQ11_20780</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49366">
        <property type="protein sequence ID" value="PHQ49366"/>
        <property type="gene ID" value="BLA24_25295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14986">
        <property type="protein sequence ID" value="PPT14986"/>
        <property type="gene ID" value="CYQ11_20780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="22154" checksum="CFF5C0B3C14AE858" modified="2018-01-31" version="1">MRGEPSCPKCGGRVRAPGLFADSWQCAVHGTVHPLQPVVPPSVEALGVVVGRAHVPVWMPWPLPVGWLFTGVVCAGDDRSGGRATAVACTGPSPLGGPGELLLVAEELGVGLGARYAGIDGPDPGPHMCVNRSPDAKVHAAGRPTPLWNVEGAPDDRAVFAGEACGLWLWAVVWPERSGLLMYDELVLTDLRDAGAEVDLLPCGALSPRILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDV6</accession>
    <name>A0A2G1XDV6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_25605</name>
        <name evidence="8" type="ORF">CYQ11_20465</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49420">
        <property type="protein sequence ID" value="PHQ49420"/>
        <property type="gene ID" value="BLA24_25605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14930">
        <property type="protein sequence ID" value="PPT14930"/>
        <property type="gene ID" value="CYQ11_20465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="111"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="34018" checksum="96C1AB5DAFEE57A0" modified="2018-01-31" version="1">MPEKTLTPEAPGPESVVLAAPETVQNKPRSLGQDAWRELRSSPLFWISSGLLVLFIFMAAFPSVFTDVDPRHADLRNHFLGKPNWTHFFQEDWFGYNIQGQSVYARTVYGARASIIVGICVTLAVTILGGLVGMLAGYFGGWVDALLSRVTDIFFGIPLLLGGLVTLQAFTHRTVWTVVFGLTLFGWMQIARVMRGAVITQKQADFVTAARALGAGTGRILFRHILPNAIGPVIVVSTIALGGYISTEATLSYLGIGLQDPVISWGVDISDAQKNLRDAPHNLLVPATFLSLTVLAFILLGDAVRDALDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDW7</accession>
    <name>A0A2G1XDW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25560</name>
        <name evidence="3" type="ORF">CYQ11_20510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49412">
        <property type="protein sequence ID" value="PHQ49412"/>
        <property type="gene ID" value="BLA24_25560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14938">
        <property type="protein sequence ID" value="PPT14938"/>
        <property type="gene ID" value="CYQ11_20510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="291" mass="32162" checksum="19A635959BBEFE91" modified="2018-01-31" version="1">MDFRTELAAFLRSRRARLRPEDVGVRPFSGRRRVPGLRREELAELAGVSVDYYIRLEQGRSQNVSDSVLDAVAGALRLDAAERAHLGHLTRALRDSPAQALAPQPVRAGIQVLLGALDEVPAYVLGRRLDILASNRLARVLFGDFDALPAERRNVAWLHFLDPGARERYPDWEQTARDTVAALRMDLGRYPCDDRLCGLLGELSVRSDDFSRLWAEHHVRENSHGIQRIRHPATGELPLLRETLHLPDEPDQALVMYVAEPGSRAQTALGALAGRGLVGGGPGGYGPLSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE16</accession>
    <name>A0A2G1XE16_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_25600</name>
        <name evidence="8" type="ORF">CYQ11_20470</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49419">
        <property type="protein sequence ID" value="PHQ49419"/>
        <property type="gene ID" value="BLA24_25600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14931">
        <property type="protein sequence ID" value="PPT14931"/>
        <property type="gene ID" value="CYQ11_20470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="352" mass="38461" checksum="64872B12EF9BEBE1" modified="2018-01-31" version="1">MTTTEKTANVPEPRAGDADGTPLLEVRDLHVEFHTRDGVAKAVNGVNYSVNAGETLAVLGESGSGKSVTAQAVMGILDMPPGKIPQGEILFRGQDMLKMSAEERRKIRGSKIAMIFQDALSSLNPVLSVGYQLGEMFRVHQGLSKKEAKAKAIELMDRVRIPAAKERVGDYPHQFSGGMRQRIMIAMALALEPDLIIADEPTTALDVTVQAQVMDLLAELQREYNMGLILITHDLGVVADVADKIAVMYAGRIVETAPVHELYKRPAHPYTRGLLDSIPRLDQKGQELYAIKGLPPNLLRIPTGCAFNPRCPKAQDICRTETPALLDVTERDGAALPGRRSACHFWKETIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE28</accession>
    <name>A0A2G1XE28_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25840</name>
        <name evidence="3" type="ORF">CYQ11_20230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49465">
        <property type="protein sequence ID" value="PHQ49465"/>
        <property type="gene ID" value="BLA24_25840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14885">
        <property type="protein sequence ID" value="PPT14885"/>
        <property type="gene ID" value="CYQ11_20230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="28454" checksum="B363DF1BD0E4195B" modified="2018-01-31" version="1">MLMPWYARVVFTAGRPFVLIAALVMSVPGEVRMAELAGWHGWFTWLMPVCVSAYAACAAVISEVRRRADLPGRVTATIGAGMALGLALAAQVVAHLIDRGYMVSSAVLVAVVSAVPPLVVAHMLHMAATPGAEITAAQKMRDLEATAEYLAGELTDALDLAGRCLVSKSHGIVNEYEELAEAAGELADGCDGLTEEIDDELAEAEQAEGKPRLGGVRQGGRGRKAVPLTVVKETVAAMKAEGAKVSGPTLAERLGCSVRSGYRYLGEVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE58</accession>
    <name>A0A2G1XE58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF402 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26165</name>
        <name evidence="3" type="ORF">CYQ11_19475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49520">
        <property type="protein sequence ID" value="PHQ49520"/>
        <property type="gene ID" value="BLA24_26165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14760">
        <property type="protein sequence ID" value="PPT14760"/>
        <property type="gene ID" value="CYQ11_19475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="25214" checksum="307859672C3AD1C7" modified="2018-01-31" version="1">MAAQTTGTAGGGSWAPGDHILWRYRGNATSSVHICRPVTVVRDTAELLAVWMAPGTDCVKPLLADGTPVHREPLATRYTKPRTTEVTRWYGPGVLKLARPGEPWSVWLFWDPDWHFRNWYVNLEEPLTRWSGGVDSEDHFLDIAVYPDRSWEWKDEDEFAQAQHAGLMTAAQAARVRAAGRSAVALIESWGQPFAGGWEGWRPDPAWTVPALPGDWDRTPTRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE62</accession>
    <name>A0A2G1XE62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1707 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26145</name>
        <name evidence="4" type="ORF">CYQ11_19495</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49516">
        <property type="protein sequence ID" value="PHQ49516"/>
        <property type="gene ID" value="BLA24_26145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14764">
        <property type="protein sequence ID" value="PPT14764"/>
        <property type="gene ID" value="CYQ11_19495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="230" mass="24138" checksum="A3621DCC3BFB361D" modified="2018-01-31" version="1">MDESSLEERPQDSAPAKVRLDKAAPAASDPALRASDADRDGVADILREALAEGRLTAEEHSERIGAVYRARTVGELAPLVRDLPAGRRPEAVPAAVRPPDASTRPAMGAAENLIAVFGGATRKGRWRVGARTNAFALFGGAEIDLTEAVFAQREVVINAYVLFGGVDIRVPENVTVRSAGAGVFGGFDVRTNEAADPDAPVVVVTGFAVFGGVSAKARRGKRLKNLRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE92</accession>
    <name>A0A2G1XE92_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_26320</name>
        <name evidence="9" type="ORF">CYQ11_19320</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49546">
        <property type="protein sequence ID" value="PHQ49546"/>
        <property type="gene ID" value="BLA24_26320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14734">
        <property type="protein sequence ID" value="PPT14734"/>
        <property type="gene ID" value="CYQ11_19320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="145"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="33516" checksum="849767FFE97F67CB" modified="2018-01-31" version="1">MGDPALLTVGTTLLCAVLAVAGVRAYVTGRDRHQALVDRLADVPALEPAGRGRAFRRTDRRLRGTRLGRWLEPRIASTGLDVTVGEFTVYTVGGAAGLWLVAAAALAPFFGPLAGVTGVWSAYAFLTWQRRKRTERFIGQLPELARILANATQAGLALRTALAMAAEEMEAPAGEELGKVADRLAVGHSVDDALAELARRLPSRELVVLVTTLVLSNRAGGTVVSSLRNLTTTLEERKETRREVRTQLSQVTVTAYVVPLMGVGTLLLMDRVAPGSIDRMTDGWLGQAAVVAAFCLYGVGFVLIRRMSRIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEA6</accession>
    <name>A0A2G1XEA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PhoH family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_26235</name>
        <name evidence="8" type="ORF">CYQ11_19405</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49531">
        <property type="protein sequence ID" value="PHQ49531"/>
        <property type="gene ID" value="BLA24_26235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14749">
        <property type="protein sequence ID" value="PPT14749"/>
        <property type="gene ID" value="CYQ11_19405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="440" mass="47986" checksum="CA6DA0046FCC2944" modified="2018-01-31" version="1">MVTSKKRRDGDRRTYVLDTSVLLADPGAMSRFEEHEVVLPVVVVTELEAKRHHPELGYFARKALRLLDEYRVQYGRLDAPIPIGELGGTLRVELNHSDPGILPAGFRLGDNDSRILAVARNLQAEGYDVTVVSKDLPLRIKASAVGLLAEEYRAELAITDSGWTGMAELTVTAGQVDELFTTERVYVPEAAELPVHTGLVLQSERGKALGRVAADGSVRLVRGDREAFGIHGRSAEQRVALDLLLDPEVGIVSMGGRAGTGKSALALCAGLEAVLERQQHRKVMVFRPLYAVGGQELGYLPGSEAEKMSPWAQAVFDTLSAVTTAEVIEEVVGRGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGANSRVVLTHDVAQRDNLRVGRYDGVVAVVERLKGHPLFSHVTLTRSERSPIAALVTEMLEDGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEN4</accession>
    <name>A0A2G1XEN4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26865</name>
        <name evidence="3" type="ORF">CYQ11_18770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49639">
        <property type="protein sequence ID" value="PHQ49639"/>
        <property type="gene ID" value="BLA24_26865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14639">
        <property type="protein sequence ID" value="PPT14639"/>
        <property type="gene ID" value="CYQ11_18770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="21498" checksum="B2800D40D47F3C40" modified="2018-01-31" version="1">MSKVVVFGAGGRAGRQAVAEARRRGHHVTAVVRDSATYADLAAEGVDVVEGDITDAAAVASLVTGHDAVIAAAAAYGPGIDSRAFFVGAAQALTGGLTAAGVRRLVVVGLSSLLPDGSGTALMDGPGFPAEFRPFCLAHGEGLAVLQSGAAGLDWLYASPAGDFDHSGTRTGTYGIGDHGDGLNRISYADFAIALLDEIDAPQHHHTHLAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XER2</accession>
    <name>A0A2G1XER2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">BLA24_26115</name>
        <name evidence="10" type="ORF">CYQ11_19525</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49744">
        <property type="protein sequence ID" value="PHQ49744"/>
        <property type="gene ID" value="BLA24_26115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16676">
        <property type="protein sequence ID" value="PPT16676"/>
        <property type="gene ID" value="CYQ11_19525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="129"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="322"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="411" mass="44633" checksum="522733F293A36C5F" modified="2018-01-31" version="1">MAVNTSPDAPMPVGQVSRLIGGWIDRLGAVWVEGQITQLSRRPGAGVVFLTLRDPSHDVSLSVTCYRAVFDRVADVVSEGARVVVHAKPEWYAPRGQLSLRAAEIRPVGVGELLARLEQLKKSLAAEGLFAAERKRALPFLPQLIGLVCGRASAAERDVLENARHRWPAVRFEVRNVPVQGVHAVPSVIEAVQELDAHPEVDVVIVARGGGSVEDLLPFSDEQLVRTVAACRTPVVSAIGHEPDTPLLDLVADLRASTPTDAAKRVVPDVGEELTRVRHLRERALRCVTAHLDREERGLAAARARPCMERPQRMVDERAEQVDALAARSRRTLGHLLDRADSELSHTLARVVALSPAATLRRGYAVLQHADGSVVRAAAEVTPEEELRARVAEGEFTVRPVAVPPAVTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEU1</accession>
    <name>A0A2G1XEU1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="6" type="ORF">BLA24_22745</name>
        <name evidence="7" type="ORF">CYQ11_14175</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="NHZO01000152">
        <property type="protein sequence ID" value="PHQ49774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49774">
        <property type="protein sequence ID" value="PHQ49774"/>
        <property type="gene ID" value="BLA24_22745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13883">
        <property type="protein sequence ID" value="PPT13883"/>
        <property type="gene ID" value="CYQ11_14175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="28375" checksum="30849677240FB153" modified="2018-01-31" version="1">MAQKVAVLGTGKIGEALLSGMIRAGWSTDALMCTARRAERAEALRARYGVEVVSNTEAAKAADTLILAVKPQDMTTLLDELAPHLPADRLVISAAAGVPTTLFEERLPAGTPVVRVMPNTPVLVDEGMSVISAGSHATEEHLLRTEAIFKPVGKTLRVPESQQDAATALSGSGPAYFYYLVEAMTDAGILLGLPRDKAHDLIVQAAIGAAVMLRDSGEHPVKLREAVTSPAGTTINAIRELEKHGVRHALIAALEAARDRSRELASGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF09</accession>
    <name>A0A2G1XF09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26310</name>
        <name evidence="3" type="ORF">CYQ11_19330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49749">
        <property type="protein sequence ID" value="PHQ49749"/>
        <property type="gene ID" value="BLA24_26310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16671">
        <property type="protein sequence ID" value="PPT16671"/>
        <property type="gene ID" value="CYQ11_19330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6703" checksum="B3429B950364637A" modified="2018-01-31" version="1">MPKRLWARSRDRSPVDDRGQTSVEYLGIIAVVVAIILVLTTTDFGTMIATAITNKIQQITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF52</accession>
    <name>A0A2G1XF52_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">BLA24_19490</name>
        <name evidence="10" type="ORF">CYQ11_11305</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49831">
        <property type="protein sequence ID" value="PHQ49831"/>
        <property type="gene ID" value="BLA24_19490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13394">
        <property type="protein sequence ID" value="PPT13394"/>
        <property type="gene ID" value="CYQ11_11305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="446" mass="47942" checksum="26BBF83EB1E1C8F2" modified="2018-01-31" version="1">MTGPDDVLLVHGGTPLEGEIRVRGAKNLVPKAMVAALLGHGPSRLRNVPDIRDVRVVRGLLQLHGVTVRPGDEPGELVLDPTYVESANVADIDAHAGSSRIPILLCGPLLHRLGHAFIPGLGGCDIGGRPIDFHFEVLRQFGATIEKREGGQYLEAPQRLRGCKIRLPYPSVGATEQVLLTAVLAEGVTELSNAAVEPEIEDLICVLQKMGAIIAMDTDRTIRITGVDKLGGYNHRALSDRLEAASWASAALATKGNIYVRGAQQRSMMTFLNTYRKVGGAFEIDDEGIRFWHPGGSLNAIALETDVHPGFQTDWQQPLVVALTQASGLSIVHETVYESRLGFTSALNQMGAHIQLYRECLGGSACRFGQRNFLHSAVVSGPTKLQGADMVVPDLRGGFSYLIAALAADGTSRVHGIDLINRGYENFMQKLKDLGANVEMPGSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF60</accession>
    <name>A0A2G1XF60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19715</name>
        <name evidence="3" type="ORF">CYQ11_11080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49870">
        <property type="protein sequence ID" value="PHQ49870"/>
        <property type="gene ID" value="BLA24_19715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13354">
        <property type="protein sequence ID" value="PPT13354"/>
        <property type="gene ID" value="CYQ11_11080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304918" evidence="1">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="13863" checksum="B815ED773A789E62" modified="2018-01-31" version="1">MPARRRLAVTGTALAAALAVIPLATGCDAAKKAVDCARVGVEITGNADDLQRTVSDANGTSDAADKILDTLDRDTKKLKEKTDNVDVRKVLDHLQQALTNVRDALRDDRKPDLTPLKDAAGELGKVCTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF97</accession>
    <name>A0A2G1XF97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20015</name>
        <name evidence="2" type="ORF">CYQ11_10775</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49916">
        <property type="protein sequence ID" value="PHQ49916"/>
        <property type="gene ID" value="BLA24_20015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13309">
        <property type="protein sequence ID" value="PPT13309"/>
        <property type="gene ID" value="CYQ11_10775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="21980" checksum="EF43D00D19FBCA2C" modified="2018-01-31" version="1">MAPRILLARHGQTEWSLSGKHTGRTDIPLLDEGRRGAKLLGERLHRAPWDALPDTEVRTSPLVRAKETCELAGFGDRAADWDALMEWDYGAYEGMTPAEIKAGRPDWLIWRDGVPEGETMAEVTARADEVVAWARSADRDVLVFAHGHILRTIAARWLGEDIFFGSRIRLDPTSLSILGWAYGAPALERWNDTGHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF98</accession>
    <name>A0A2G1XF98_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">QacE family quaternary ammonium compound efflux SMR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_19755</name>
        <name evidence="7" type="ORF">CYQ11_11035</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49875">
        <property type="protein sequence ID" value="PHQ49875"/>
        <property type="gene ID" value="BLA24_19755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13349">
        <property type="protein sequence ID" value="PPT13349"/>
        <property type="gene ID" value="CYQ11_11035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="106" mass="10837" checksum="1F011C21533986E1" modified="2018-01-31" version="1">MAWVLLVVAGLLEVGWAVGMKYTEGFTRLWPSVGTVAGIVASMLLLAQAARTLPIGTAYGVWVGIGAAGAAVLGMVVLGEPVTAARIFFICLLLVAVVGLRATSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN1</accession>
    <name>A0A2G1XFN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eccD</name>
        <name evidence="3" type="ORF">BLA24_20760</name>
        <name evidence="4" type="ORF">CYQ11_10020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50042">
        <property type="protein sequence ID" value="PHQ50042"/>
        <property type="gene ID" value="BLA24_20760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13180">
        <property type="protein sequence ID" value="PPT13180"/>
        <property type="gene ID" value="CYQ11_10020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="438" mass="44422" checksum="ADDD8DD3F49F9727" modified="2018-01-31" version="1">MTLVGDRRRVDLVLPADEPIGLLLPDVLRLLDDKAGERPAARHLITADGTVLPQDGTLAGAGVPDGALLRLVRVHDAPSAPVVHDVTDEVAEDLDVRAWRWRPEAREWTAVLAAVGLAVTTGVLARTGLGGGAVAAPLMVAAALAAAVGAVVAKAVSAGRTLGTALMLTGGALGTLAAWTAADAHAWPGVARLASVAAVLAVTLTLLGLFSRLGRGGLIGAGAVAAGTAAWEAVAAFQSDPARLGTVMAVVSVVVLGLLPRLALTSAGLTALDDSRSGGASVSRHRVETALVATHRGLALATVAVAGSATAGGLLAVAEAPTAWTVTLTAVLAVVLLSRARAFPLVAEVVALLAAGLLLLVRLAVLWIDHTHGGVYGPLAALWLATLVPLGVLAVRPPEHVRVRLRRAVDLVETTGVIALFPLAVGVFGVYVRLLHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ3</accession>
    <name>A0A2G1XFQ3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">crcB</name>
        <name evidence="10" type="ORF">BLA24_20340</name>
        <name evidence="11" type="ORF">CYQ11_10445</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49969">
        <property type="protein sequence ID" value="PHQ49969"/>
        <property type="gene ID" value="BLA24_20340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13254">
        <property type="protein sequence ID" value="PPT13254"/>
        <property type="gene ID" value="CYQ11_10445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="118" mass="12176" checksum="66DBFA8860AEE4F9" modified="2018-01-31" version="1">MNWLLVVAGAMAGAPLRYLTDRAVQSRHDSVFPWGTFAVNVAGCLILGLLTGALPDDRVRLLLGTGFCGALTTYSTFSYETLRLAQGGARGYALANAAASVVCGLGAASAGVALGRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG19</accession>
    <name>A0A2G1XG19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21700</name>
        <name evidence="6" type="ORF">CYQ11_09085</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50190">
        <property type="protein sequence ID" value="PHQ50190"/>
        <property type="gene ID" value="BLA24_21700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13026">
        <property type="protein sequence ID" value="PPT13026"/>
        <property type="gene ID" value="CYQ11_09085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="152" mass="16833" checksum="C197A792C2FC06A0" modified="2018-01-31" version="1">MAIAVGDKAPDFALKNQHGETVRLSDFRGEKNVVLLFYPFAFTGVCTGELCALRDELPKFANDDVQLLAVSNDSPFSLRVFAEQEGLEYPLLSDFWPHGEASRAYGVFDEEKGCALRGTFIIDKEGVVRWTIVNGLPDARDLNEYTKALAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG79</accession>
    <name>A0A2G1XG79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21825</name>
        <name evidence="4" type="ORF">CYQ11_08960</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50211">
        <property type="protein sequence ID" value="PHQ50211"/>
        <property type="gene ID" value="BLA24_21825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13005">
        <property type="protein sequence ID" value="PPT13005"/>
        <property type="gene ID" value="CYQ11_08960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="28486" checksum="9377A260874B4714" modified="2018-01-31" version="1">MGNEVSQDSGKPRYLQIAHDLAEQIRAGILEPGSQVPSESEVMERYGVSQGTVRKAMAELRTSGLVETHHGRGSYVKSLPPVRRKSSDRFRRSHRRDGKGAYLAEAEQAGQKPRVQVLYVGPTDAPAEIADRLGVAAGDKVLARRRRYFSDNTPTEEATSYLPWPLATAIPQLLSENPGSGGIYARLEEHGLTLGEYVETVRARLATKQEVSALRLSPGSPVIHLVRNAVTRDGRVVEVCDTIMAADRFVLEYRIPSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGD5</accession>
    <name>A0A2G1XGD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_22300</name>
        <name evidence="8" type="ORF">CYQ11_08485</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50287">
        <property type="protein sequence ID" value="PHQ50287"/>
        <property type="gene ID" value="BLA24_22300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12927">
        <property type="protein sequence ID" value="PPT12927"/>
        <property type="gene ID" value="CYQ11_08485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="402" mass="40804" checksum="637D9CFA22819897" modified="2018-01-31" version="1">MPLALLALAVSAFGIGTTEFVMMGLLPNVADDLHTSVPTAGYLVSAYALGVVVGAPLLTALGARIPRKRMLVLLMGLFTIGNLASALAPSFGPLVAARVLAGLPHGAFFGVGSVVAARLVSQGRQARAVATMFLGLTVANVVGVPTATLLGQHLGWRATFLVVTGIGLLAMAALAALVPQLPREEHGGLARELRALGGRQVLLGLLTAVFGFAGVFAVYSYLASMSTEVTGFSETSVTVVLALFGTGMTLGALAAGPLTDRALRPTLYGSLAALAAVLVLFDFTVHVKWAALVTVVLLGAVGFMTTTPLQMLVMLGARQAPTLAAASNHSAFNLANAGGAWLGGAAIAAGWGWTSPTLVGAALAVVGLGVALLAGLLDRGEEEGSRVVAGAHWEHVPQHQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGN4</accession>
    <name>A0A2G1XGN4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_22375</name>
        <name evidence="7" type="ORF">CYQ11_08410</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50299">
        <property type="protein sequence ID" value="PHQ50299"/>
        <property type="gene ID" value="BLA24_22375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12914">
        <property type="protein sequence ID" value="PPT12914"/>
        <property type="gene ID" value="CYQ11_08410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="314" mass="35100" checksum="8B8F11C139742F5C" modified="2018-01-31" version="1">MATVVTRVRRSFSTHWYAWAMVLPVVIVLAVLVGYPLGRGVYLSFTDANEANVGRTIGVNRIPATYQFVGLDNYWKVLSGQEGHFYSRLTWTVLWTASCVLLHYALGLGLALLLNRKVRFRALYRVLLILPWAVPAFVATFSWRLMFNEKYGVLNALLTQVGMDPVDWLGDATLQKVSAVAVNVWLGVPFMMVAILGGLQSIPAELHEAAEMDGASPWQRFRHVTLPGLRPVSGTVILLGVIWTFNMFQVIYLLIGQGASSESEILVTYSYRLAFQGVRDYAGSATYGILILSLLLVFAVFYRRLLTRQEAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX0</accession>
    <name>A0A2G1XGX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_16805</name>
        <name evidence="9" type="ORF">CYQ11_16480</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50494">
        <property type="protein sequence ID" value="PHQ50494"/>
        <property type="gene ID" value="BLA24_16805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14251">
        <property type="protein sequence ID" value="PPT14251"/>
        <property type="gene ID" value="CYQ11_16480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="130"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="27347" checksum="4E1E47B782E3F3F1" modified="2018-01-31" version="1">MRTELVHSLWAVMLAVAATACVVVMGRRVRARRSARRRGAALFGERAVASRGGRRRQWPGRGGVARGGRLPVVAAGAGGVACVAFTVGVSGCVVTLVATAYVLWRRRRKTARAEGEVTAEEAATQLPLAADLLAACLAAGASPREAAEAVGGSLGGPVGERLAQAAAEVRLGGEPATAWGRLGSVPGAAGLARCLERAQATGVPAVEPMSRLAERLRAEQGRAAAIRARRAGVLATAPLGLCFLPAFLTVGVVPVVIGLASGLMRGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH03</accession>
    <name>A0A2G1XH03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17000</name>
        <name evidence="2" type="ORF">CYQ11_16280</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50524">
        <property type="protein sequence ID" value="PHQ50524"/>
        <property type="gene ID" value="BLA24_17000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14222">
        <property type="protein sequence ID" value="PPT14222"/>
        <property type="gene ID" value="CYQ11_16280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="203" mass="22367" checksum="5491EA55DC49D711" modified="2018-01-31" version="1">MTPVRLRRLSRWLVEDLREDLAGLYVGSRATPPGDPYRRPSRQNFVDRLIVDMRRPELAMVIAETDRLMGCAFGLPVQCDGSWWLGFEGTLPRSVGQLTVSGNAFAFTGILIRPHPQDRGLARQVQERLLTGHQAMLGATLVDRADRPTLAAFRSWGWLDIGELRRPLGAATLRAPVFPLGERTTVRLEGLVTMPGDGGPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH69</accession>
    <name>A0A2G1XH69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17400</name>
        <name evidence="4" type="ORF">CYQ11_15875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50583">
        <property type="protein sequence ID" value="PHQ50583"/>
        <property type="gene ID" value="BLA24_17400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14162">
        <property type="protein sequence ID" value="PPT14162"/>
        <property type="gene ID" value="CYQ11_15875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304873" evidence="2">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="104" mass="10200" checksum="CC6DECC45B1C44F8" modified="2018-01-31" version="1">MASTRTAARVFAALAALPMAALLLAGVAQADDGTQVANRGANAAAAGIVGSGVGGSNHGNSTTAQQQATGTGASNQANTASAIGYGGHTVIQQENVRITFTNMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHG9</accession>
    <name>A0A2G1XHG9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17750</name>
        <name evidence="4" type="ORF">CYQ11_15525</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50641">
        <property type="protein sequence ID" value="PHQ50641"/>
        <property type="gene ID" value="BLA24_17750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14104">
        <property type="protein sequence ID" value="PPT14104"/>
        <property type="gene ID" value="CYQ11_15525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="61"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="237" mass="25722" checksum="FFBD34924950E13D" modified="2018-01-31" version="1">MTTPMATTPTTTAEPPDTAAPGRSPDAARPGSAGEHLVQRRLGTADRAGRFYDDQVLSHLNARMREFVARQEMFFLATADRRGTCDNTFRAGPPGFLRVLDDRTLAYPEYRGNGVLASLGNIEENPHVGILLIDFCRDRIGLHVNGSARLVDDADLRSAHPALPRDEAPGRRAVVWVEVTVEEAYVHCAKHIPHLRKAADETGGDGRAWGTDDTRRKGGDFFGAAAAGKAAPASRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL6</accession>
    <name>A0A2G1XHL6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50738">
        <property type="protein sequence ID" value="PHQ50738"/>
        <property type="gene ID" value="BLA24_18325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="232" mass="25172" checksum="0E2105F0A1F62506" modified="2018-01-31" version="1">MPSFYEELMKADFSGLETLGGKWEEVHGKINGLPGRILDEVLKPLRDKGYWEGAAAPYAWTQIDDMQRQVESAAKVAESVAKVVKDGAGELKAVQRELKDAVDRIKQKTGFSVSHEGKVSYTGTIHADTQKDVDHAQDEIIEILRRAVVTDQNLSMSLMADVGVDTWFNAKPQLTDINHTGTLGIERYNQLGLALAGEDPTPSGTARARTASAGTGRRARAIRTGPSPPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHT5</accession>
    <name>A0A2G1XHT5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18620</name>
        <name evidence="3" type="ORF">CYQ11_14660</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50786">
        <property type="protein sequence ID" value="PHQ50786"/>
        <property type="gene ID" value="BLA24_18620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13956">
        <property type="protein sequence ID" value="PPT13956"/>
        <property type="gene ID" value="CYQ11_14660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="173" mass="18937" checksum="66480FAC795EF06A" modified="2018-01-31" version="1">MTTETQPQTQSRTTTNPADPNTPTDFASLAAQPIGYWSWIAHTAVLRHLRGAMARVDIAQPQWWVLNQVDRAAEAGLTREQIRDNLRLVLDVGADTIVQATDGLLARGWLTDDAEGFLHLTDAGREAKARTKEVVDRVRAEVHAGITDEEYVAALKVLQRMVSNVGGIGALTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI18</accession>
    <name>A0A2G1XI18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17690</name>
        <name evidence="4" type="ORF">CYQ11_15585</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50888">
        <property type="protein sequence ID" value="PHQ50888"/>
        <property type="gene ID" value="BLA24_17690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16584">
        <property type="protein sequence ID" value="PPT16584"/>
        <property type="gene ID" value="CYQ11_15585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="93"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="38845" checksum="93976E282EEBCFBB" modified="2018-01-31" version="1">MTQGAGQGPAARTTAAMPPFPGYAAPPPMPAYAHSAPPGEVAPEYPDYPEGYTPTARDLPVLNRPAPPQDVPTVELTPLAAPQPQPVPAGRGPLYVVGDVHGYLDELHEALAAQGLIDEQGHWAAGNARLWFLGDFTDRGPDGVGVIDLVMRLSAEAAAAGGYCKALMGNHELLLIGAKRFADTPVNSGAGTASFQAAWLLNGGQRTDMERLEDHHLQWMSRLDAIAEEDGHLLVHSDTTAYLEYGDSIEAVNDAVTEALQRNDPDECWELFRKFTKRFAFRDEDAGPLAVRELLQAYGGHRIVHGHSPIPYLLGEVGTEDADGEESGTPLVDGPHLYADGLALAMDGGVTMAGKLLVVQLPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI82</accession>
    <name>A0A2G1XI82_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_14150</name>
        <name evidence="6" type="ORF">CYQ11_13925</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50937">
        <property type="protein sequence ID" value="PHQ50937"/>
        <property type="gene ID" value="BLA24_14150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13842">
        <property type="protein sequence ID" value="PPT13842"/>
        <property type="gene ID" value="CYQ11_13925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="16513" checksum="DC2B866757B7814C" modified="2018-01-31" version="1">MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVNSASLGLGVTALIGIQLSDAADHEDVARRLRDLEEIEDCWFIAGDDSYMLKVRVGDVDGLERTIRRLSGTKGVSRTRTTIVLSTKWENRVGELPEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIH5</accession>
    <name>A0A2G1XIH5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein BLA24_14590</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14590</name>
        <name evidence="4" type="ORF">CYQ11_13485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51010">
        <property type="protein sequence ID" value="PHQ51010"/>
        <property type="gene ID" value="BLA24_14590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13768">
        <property type="protein sequence ID" value="PPT13768"/>
        <property type="gene ID" value="CYQ11_13485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="16297" checksum="0E991F24C098D3A2" modified="2018-01-31" version="1">MALDQSFVGRTYPATDPYEVGREKIREFAEAIGDANPVYTDAEAAKAMGHPDVIAPPTFVFAITFKAARQVIRDPQLGLDYSRVVHGDQKFAYTRPVRAGDRLTVTSTIESIKSLAGNDVLAVRGEVHDQSGEHVVTAHTMLVARAAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIW8</accession>
    <name>A0A2G1XIW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin acylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_15580</name>
        <name evidence="7" type="ORF">CYQ11_12495</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51177">
        <property type="protein sequence ID" value="PHQ51177"/>
        <property type="gene ID" value="BLA24_15580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13599">
        <property type="protein sequence ID" value="PPT13599"/>
        <property type="gene ID" value="CYQ11_12495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304812" evidence="5">
        <location>
            <begin position="36"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="955" mass="104784" checksum="8811DDC8F944576B" modified="2018-01-31" version="1">MPANKSGPGKKKKGRRARLLVITFVLLLVAGVAFGAYWSVSTVRASFPQTDGTLQLKGLSGQVKVVRDDHGIPQVYADSPEDLFRAQGFVQAQDRFWEMDVRRHLTAGRLSEMFGSGQVETDAFLRTMGWRKVAQEEYDTKLSASTKKYLRAYSEGVNAYLKDHQGKSLSVEYAALEFENDYKPEAWTPVDSVAWLKAMAWDLRGNMRDEIDRSLAASRLTPQQIEDLYPAYPYDRNKPIVEGGAVDSAKAFDPKGGQGGSTQAGGPGAVTGGAGAAAGLRGSLAALSGSLEKVPALLGPNGNGIGSNSWVVSGKYTTTGKPLLANDPHLAPQMPSLWYQMGLHCNKTSAQCPFDVAGYSFSGMPGVVIGHNKDIAWGMTNLGADVSDLYLEKVTADSYLYDGKQVPFTTRKETIKVAGEQSREITVRETNSGPIVSDRNDQLRKVGEKAPVKEPAPDRAEGYAVALRWTALQPGKTMDGLFALDQATDFPSFRKAAADFEVPSQNLVYADTKGNIGYQAPGRIPVRGKAKGENEGRTPGQPAGTGRNQAGTDAKPDDKSVTPAPDGRYPAPGWDPAYQWTGWVPQSALPWDYNPQRGYIVTANQAVADKKYPYLLTQDWGYGARSQRIGELIESKIKDGGKISTDDMQKMQTDNSSEIAKLLTPYLLKIDLKGPNERETKYLREAQKLLKDWDYKQEADSAAAAYFNAVWRNTLKLAFGNKLPKELRVKDQCLRVRPVDSSAPQEDLDGTTRLVLECGERDPDAAQPDGGDRWFEVVRGILGKPDNDWWKTSSPRSNPDAGTRNRDELLARAMKDARWELTSKLGKDVTSWSWGRLHQLNLKNQTLGKEGPGIVQWMLNRGPWNLAGGEAAVNAAGWNAAGGYDVVWVPSMRMVVNLDDMDKSRWINLTGASGHAYNAHYYDQTDKWAKGELLPWAFSPDAVEKAKDAVLTLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ64</accession>
    <name>A0A2G1XJ64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4287 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16070</name>
        <name evidence="2" type="ORF">CYQ11_12005</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51265">
        <property type="protein sequence ID" value="PHQ51265"/>
        <property type="gene ID" value="BLA24_16070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13509">
        <property type="protein sequence ID" value="PPT13509"/>
        <property type="gene ID" value="CYQ11_12005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="76" mass="8987" checksum="07DFA89A2B2D4A0E" modified="2018-01-31" version="1">MSHVFSDETHRNMLSRIPHCTGREVAEWLRTVEEGPSLFRFEEKVSWLRGEHNLAYGHAKAIVHEYDLQRAARKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJC5</accession>
    <name>A0A2G1XJC5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">BLA24_15910</name>
        <name evidence="9" type="ORF">CYQ11_12165</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51239">
        <property type="protein sequence ID" value="PHQ51239"/>
        <property type="gene ID" value="BLA24_15910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13537">
        <property type="protein sequence ID" value="PPT13537"/>
        <property type="gene ID" value="CYQ11_12165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="35354" checksum="0FD5B2D4BFF05244" modified="2018-01-31" version="1">MTGIKTTGEKKLMLFSGRAHPELAEEVAHQLGVGLVPTKAFDFANGEIYVRFQESARGADCFLMQSHTAPINKWVMEQLIMIDALKRASARSITVILPFYGYARQDKKHRGREPISARLIADLMKTAGADRLLTVDLHTDQIQGFFDGPVDHLFALPILADYVGAKVDRDKLTVVSPDAGRVRVADRWCDRLGAPLAIVHKRRDKDVANQVTVHEVVGDVKGRVCVLVDDMIDTGGTICAAADALFAHGAADVIVTATHGVLSGPAADRLKNSKVSEFVFTNTLPTPNELELDKITVLSIAPTIARAVREVFEDGSVTSLFDELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJN7</accession>
    <name>A0A2G1XJN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13240</name>
        <name evidence="3" type="ORF">CYQ11_00960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51474">
        <property type="protein sequence ID" value="PHQ51474"/>
        <property type="gene ID" value="BLA24_13240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11656">
        <property type="protein sequence ID" value="PPT11656"/>
        <property type="gene ID" value="CYQ11_00960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="283" mass="29952" checksum="5F142256CD865167" modified="2018-01-31" version="1">MMSAVTYKMVRMTELLASSDDVRPLTALDDGSGPNLLVVHPGGGDATAWDGVTRRLTDDFRVVRINRRIYAPGADIALPHSMAVEAADILRVAELLDAPVLLVGHSSGAVAALEAALLDPSAFAGLFLYEPPMPTRELIAGAAGVRARAALDTGDPVEAMRIHMRDIVRMPVSTVDAMFADQELRAMCCAHATAQIADDEAIDALGVGIERFADLKTPTTLIEGDLSPAHLRERLSDLAATLPNARIVTLTGHGHAAHFTAPDALADAIRDMAEQVLQAGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJT3</accession>
    <name>A0A2G1XJT3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar hook-length control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13325</name>
        <name evidence="4" type="ORF">CYQ11_01045</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51486">
        <property type="protein sequence ID" value="PHQ51486"/>
        <property type="gene ID" value="BLA24_13325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11668">
        <property type="protein sequence ID" value="PPT11668"/>
        <property type="gene ID" value="CYQ11_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304824" evidence="2">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="18443" checksum="FAD61B281F845804" modified="2018-01-31" version="1">MRSDKLASLAGAAALAATALLLAPSPAHAAPPATHPGMTWAKMADGPDGTVQVGGPGGSPSNPYQGDTPASAVLPVLCLKVDGSPVPDGITPGFYTGWAQGTVAASRPVRGSRLNSRNAADSVCQAEFGAGWRMAEFHDGHYGPDLAWTGGWTFWAYGSVPAGTRMWTAINDQRANPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJU6</accession>
    <name>A0A2G1XJU6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_13825</name>
        <name evidence="8" type="ORF">CYQ11_01520</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51409">
        <property type="protein sequence ID" value="PHQ51409"/>
        <property type="gene ID" value="BLA24_13825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11750">
        <property type="protein sequence ID" value="PPT11750"/>
        <property type="gene ID" value="CYQ11_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00118">
        <property type="entry name" value="BLACTAMASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="6">
        <location>
            <begin position="41"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="30391" checksum="A2FD5F44F85A83A8" modified="2018-01-31" version="1">MAAAVSPQTAHAATPGGGISRRLSSLEREHSARLGVFARNLKTGRTVLHRADERFPMCSVFKTLAVAAVLRDLDRDGEFLAKRVHYTEKETKDSGYAPRTGLPENLAHGMTVEELCGAAISFSDNAAANLLMRELGGPTAVTRFCRSAGDTTTRLDRWEPALNTAEPWRTTDTTTPRAIGHTYARLVLGDVLAPRDRERLTGWLLANTTSAKRFRLGLPAEWTVADKTGGGDYGTNNDVGLAWTPDGTPIVLAVLTTKHEPKPPADDPLVARAAELLATALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJU7</accession>
    <name>A0A2G1XJU7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13765</name>
        <name evidence="2" type="ORF">CYQ11_01460</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51451">
        <property type="protein sequence ID" value="PHQ51451"/>
        <property type="gene ID" value="BLA24_13765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16282">
        <property type="protein sequence ID" value="PPT16282"/>
        <property type="gene ID" value="CYQ11_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="38611" checksum="7DBE9E3F1F8EC08E" modified="2018-01-31" version="1">MNDELGLDADGPVLLVGGYGTVGTELARLAAPSWPLTLTGRTVERGEALAAETGARLRTWDLADPTPFRARVRAVVGVVNDPDDRVLRAAMAGGVPFADVTRWTARMQRAATLGAMRAPHSPVLLSSAWMGGVSSLVAAHLAAGVGGADVVEVAIRWDVGDRAGVDSVEFMDRLGLDYEVVRDGRRHTVAPLSEVRRVRIGDDVTRVARIDTPEQFTLPLTLGTTTATTRIGFSSAASTAALLAVKRLGFFRWGRGDRFTPARRALLYAPGRGGTARFRVDVTHDGRTSSATVTDPAGQAHLTAVGALLALRRVLGTDGAPAPRGVAFPEQTPHPDRLPGDLDALGVTLRVSTGPVRASGDVEGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJW9</accession>
    <name>A0A2G1XJW9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13555</name>
        <name evidence="4" type="ORF">CYQ11_01275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51526">
        <property type="protein sequence ID" value="PHQ51526"/>
        <property type="gene ID" value="BLA24_13555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11709">
        <property type="protein sequence ID" value="PPT11709"/>
        <property type="gene ID" value="CYQ11_01275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="391" mass="40483" checksum="ECE8A2C78CADD785" modified="2018-01-31" version="1">MTSTKAVAWAGGAAYLLVVGLLVGGATRASGTVHGVGALLAVSLLAGVVRRMPLLALAVALFGSTAVVVGTPSSAPESPAASYQGQFLSYLAVDLVLGFVVATCARRASTVAVAVSFVVQLLMIGVFAHGDDLSVTGVIALLAMAASCMAGLLRRERREHAVALRSQEVAEAVTAERLRIARELHDMVAHSIGVIAIQAGVGSRVIQTQPAQAREALRTIETTSRETLSGLRRTVVSLRQAERGVTASERSPLAPAPGLADLERLAAATADAGVRVDVRRSGEQRPLPADIDLSAYRIVQEALTNVVRHAGTGRCRVAVDYGDEELSVEVVDDGRGATGNGPAHGFGIIGMRERVGLLHGHLSAGPRPEGGFRVAARLPLPAPLGVPVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK54</accession>
    <name>A0A2G1XK54_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12980</name>
        <name evidence="3" type="ORF">CYQ11_17340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51606">
        <property type="protein sequence ID" value="PHQ51606"/>
        <property type="gene ID" value="BLA24_12980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14399">
        <property type="protein sequence ID" value="PPT14399"/>
        <property type="gene ID" value="CYQ11_17340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="128" mass="13907" checksum="9514CF9AC095802C" modified="2018-01-31" version="1">MAVELNHTVVHATDKQASAHFLAGILGLRVGAPFGPFVPVDLANGVTLDFYENAGAPVTSHHYAFLVSEEEFDVAMARIEAAGITYYADPHHTDPGHINRLFGGRGVYFTDPDGHNMEIMTRPYGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK58</accession>
    <name>A0A2G1XK58_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phoU</name>
        <name evidence="5" type="ORF">BLA24_13050</name>
        <name evidence="6" type="ORF">CYQ11_17410</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51617">
        <property type="protein sequence ID" value="PHQ51617"/>
        <property type="gene ID" value="BLA24_13050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14410">
        <property type="protein sequence ID" value="PPT14410"/>
        <property type="gene ID" value="CYQ11_17410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="231" mass="25392" checksum="5AED2A033E5C5ACA" modified="2018-01-31" version="1">MRDAYHEELDSIGEGLVEMARLVGSAIGRATTAILDADLKLAETVIAADTKVDDLQRDLEARAITLLARQQPVATDLRIVVTSLRMSADLERSGDLAQHVAKLARLRFPESAVPRDLHATILEMGQLAQRLMAKAAEVIITKDVDLALQLEHDDDAMDLLHRALFQHLMDDRWQHGIETAVDVTLLGRYYERFADHAVSVAKRVVYLVTGEHADELAQAEGRTGAGPAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK97</accession>
    <name>A0A2G1XK97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12460</name>
        <name evidence="2" type="ORF">BLA24_28065</name>
        <name evidence="4" type="ORF">CYQ11_17575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48915">
        <property type="protein sequence ID" value="PHQ48915"/>
        <property type="gene ID" value="BLA24_28065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51640">
        <property type="protein sequence ID" value="PHQ51640"/>
        <property type="gene ID" value="BLA24_12460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14436">
        <property type="protein sequence ID" value="PPT14436"/>
        <property type="gene ID" value="CYQ11_17575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="137"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="29972" checksum="EC80F33CA526481E" modified="2018-01-31" version="1">MTDFPEGTPCWADAMFKDVEGAKRFYGELFGWTFGEAASEYGNYTQAHSDGKAVAAVVPTMPGGDESPSAWCLYFASDDVHRTAEEIKNAGGALLMEPMQVGSFGSMVIAKEPSGAVFGVWQAAGHRGFEKTDEPGSYCWAELFTREPAKADDFLKKVFPYGAQKVECDDSPETQGMDFKVFSLGGGGQDGQDRPVLGRMKMGDEFPKDIPAYIQVYFSVPNCDAAVETAQRLGGRLYFGPMDSPFGRFAALSDPQGAAFAVLDASTKVGEMPRMTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKD5</accession>
    <name>A0A2G1XKD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_11465</name>
        <name evidence="9" type="ORF">CYQ11_02700</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51703">
        <property type="protein sequence ID" value="PHQ51703"/>
        <property type="gene ID" value="BLA24_11465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11952">
        <property type="protein sequence ID" value="PPT11952"/>
        <property type="gene ID" value="CYQ11_02700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="38"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="498" mass="50338" checksum="0DDE57E60C5FD476" modified="2018-01-31" version="1">MTLASAAEADRSTPVRGLRPVSGKAPSPAKADSRRWWGLAVLGLSQLIVLLDSTVVNIALPSAQADLGMDDGARQWVVTSYALAFGGLLLLGGRIADLVGRKRAFLIGVAGFGAASALAGAAPSPGVLFAGRALQGAFGALLAPSAMSLLTTTFTDPRERGKAFGIFGAIAGAGAAAGLILGGVLTQYLDWRWCMYVAVPVEVVVLVGAVLLLDDPAGRAGGRLDLMGAALGSGGLVAIVYGCAEAESRGWGGTVVPSLLAGGALLLALFVLWQARSPHPLLPLRVVRDRRRAGAFLLAGLSPVATFGMFLFMTYYFQVVQGYSAVRTGLAFLPLTASVVVGSTQIAARLVPFVAPRLVVVPGLLLGASGMLVLSHVEAGSSYAAHVLPGLVLTGLGMGATMMTVMATATAGAPPRDAGVTSAMVSTAQQTGAAIGTSVLNTLAAGETAAYLAGHPGARAEATVHGFTTSLGWVAVLLVLAAALAAALLTRPRERAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKE1</accession>
    <name>A0A2G1XKE1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11360</name>
        <name evidence="4" type="ORF">CYQ11_02595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51686">
        <property type="protein sequence ID" value="PHQ51686"/>
        <property type="gene ID" value="BLA24_11360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11935">
        <property type="protein sequence ID" value="PPT11935"/>
        <property type="gene ID" value="CYQ11_02595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="751" mass="84401" checksum="5494FF60CCC67C8F" modified="2018-01-31" version="1">MANPFELPRFYMPYPARLNPHLERARTHSKAWARDMRMVEGSGIWDESDFDSHDYALLCAYTHPDASGPELDLVTDWYVWVFFFDDDFLEKFKRTGDTRGAREYLDRLYAFMPLDAGEPSPEPANQVEAGLADLWARTVPGMSEGWRRRFRESTWNLLEESMWELSNINEGRVANPVEYIEMRRKVGGAPWSANLIEHAAGAEVPDAVAASRPLCVLRDTFADGVHLRNDLFSYQREIEAEGELSNAVLVFERFLDCDTQQAADAVNDLLTTRLQQFEHTALTEVGPLLQEHGLDPTAYADVFAYVKGLQDWQSGGHEWHMRSSRYMKESSGHASSPVAGALLGGPLGLGTSAARLVPSILASLPARARSFTHVPFQRVGHLPLPDFHMPYETRLNPHLAATRRHNVDWSQRTGILTPSPADPLAGFWNEEKLRDYDLGLCAAGINPDATVAELDLGTDWLTWGTYGDDVYPALFGRARDLASAKACNERLRLFMPLEGEPGVPALNCMERGLADVWSRTVAPMPPEARRALRQSIEDMLDSWLWELDNQALNRIPEPVDYIEMRRKTFGSDLTMSLARLRHGKSLPPEVLRSRPVQAMEHAASDYAMLMNDVFSYQKEIQFEGEVHNAVLVVQNFFDCGRDQALKIVNDLMTSRMREFEHVLAVQLPALCAEFGLDAEARATLDGYAQELKHWMPAILTWHDGCRRYREEDLLRHHTVPAVPAPAAAPVPGGPTGLGTSGVRIAELLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKE7</accession>
    <name>A0A2G1XKE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51661">
        <property type="protein sequence ID" value="PHQ51661"/>
        <property type="gene ID" value="BLA24_12600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="151" mass="16850" checksum="7B4D32891037829F" modified="2018-01-31" version="1" fragment="single">VYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLTVRVPADNAEFVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKVAEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKP1</accession>
    <name>A0A2G1XKP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11495</name>
        <name evidence="3" type="ORF">CYQ11_02730</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51709">
        <property type="protein sequence ID" value="PHQ51709"/>
        <property type="gene ID" value="BLA24_11495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11958">
        <property type="protein sequence ID" value="PPT11958"/>
        <property type="gene ID" value="CYQ11_02730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="63" mass="6529" checksum="3A96B022E4BA0E68" modified="2018-01-31" version="1">MRRWTTVLRGAAAAAEVLGWWAGLTACWAVLISTLEPLDLQIGAGAALLAALAARGARRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL20</accession>
    <name>A0A2G1XL20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08145</name>
        <name evidence="2" type="ORF">BLA24_10650</name>
        <name evidence="1" type="ORF">BLA24_11215</name>
        <name evidence="4" type="ORF">CYQ11_00595</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000134">
        <property type="protein sequence ID" value="PHQ51871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000127">
        <property type="protein sequence ID" value="PHQ51963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51871">
        <property type="protein sequence ID" value="PHQ51871"/>
        <property type="gene ID" value="BLA24_11215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51963">
        <property type="protein sequence ID" value="PHQ51963"/>
        <property type="gene ID" value="BLA24_10650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52399">
        <property type="protein sequence ID" value="PHQ52399"/>
        <property type="gene ID" value="BLA24_08145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11600">
        <property type="protein sequence ID" value="PPT11600"/>
        <property type="gene ID" value="CYQ11_00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="133" mass="14447" checksum="BD3BAF5B7413D12E" modified="2018-01-31" version="1">MAIRRTLRVGANSGTPVEDLGITPDVPYRMTRRDLLEGNSDLFERAGQVLKGLTPHPVAITEATMTDGALRLKVQATNIDRLDVYVDQRPRNSVDLTDGQADITIPDTSTAQSARVEGFADSRLVASRTARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL42</accession>
    <name>A0A2G1XL42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11875</name>
        <name evidence="4" type="ORF">CYQ11_03115</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51859">
        <property type="protein sequence ID" value="PHQ51859"/>
        <property type="gene ID" value="BLA24_11875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16323">
        <property type="protein sequence ID" value="PPT16323"/>
        <property type="gene ID" value="CYQ11_03115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="495" mass="53425" checksum="14BFAF768BD9B76E" modified="2018-01-31" version="1">MSTGSRDFIARHHLWDDRQRTAAAELEAALESLDFVRLVFADPHGLARSKTLTAEAFRTVLRNGMDYSPGPFVFDTGHATAVDFTVAGGGIGVDELLGAGDFVLVPDPLTFRELPYTGPRTGWVIGDEYLRSGAPHPLSSRALLRRLCGELRGKGLDYVVGLEVEWYLTRLVDEHYSGQPGGFGVQGLPPAVQPVNGGYQFNLDGLTDALEPVLAPLTRALTDLGLPLRSVEHESGPGQLEFTFAPQSALDAADAMLLFRTTTKQVCARLGHHASFMALPGLPGLDASGWHLHQSLACAATGENLFTAPDDRSALSETGDRFLAGLLAHAADAALLCVPTVNGYRRMNDRFSLAPSRAAWSVESRSAFLRVLGAHGDPAAHIENRMGEPCANPYLYLAGQLAAGLDGMEHKLVPDGPAADPHDTALPPLPRSLREALDALAASDFYRQVLGAPLTECLLRLKTSELRRYTAWQAGAAADDAHVSEWEHREYFATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL77</accession>
    <name>A0A2G1XL77_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10790</name>
        <name evidence="4" type="ORF">CYQ11_00760</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51931">
        <property type="protein sequence ID" value="PHQ51931"/>
        <property type="gene ID" value="BLA24_10790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11624">
        <property type="protein sequence ID" value="PPT11624"/>
        <property type="gene ID" value="CYQ11_00760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="360" mass="40587" checksum="8506D7ED6ACFA9DA" modified="2018-01-31" version="1">MTTLPAPGVEPDGALAPGRYPSFRLPSFPRFQSALHRPGIEGLEAFCRTWLDDNLRHAHDESPRDFEEFLNQRTSLWNLLAYATTDTERTKTICHWIDVLFSIDDLFVHAPSPRLERLGLHRLDVVLDDDQPFPGTAYPSVLVALKERIRVGMSPALWNRFAHEIKGFFAACRMEREWLRAGAAVDLPAYEKSRVKSVGECCFPLLEYGLDIDLTAHLARMPELGRLNRLVARHWMGVNDIFSYRKELYSGDTVNEIALTLESGGSLQAAVDRVADTVRRTEEEFCALSGGLLATAAGQDPALARYVEALRWMIAGNLTWSYITPRYNGHGHVWAGHTAATVVLTPHRTLYRPEPAHRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLJ8</accession>
    <name>A0A2G1XLJ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09880</name>
        <name evidence="2" type="ORF">CYQ11_04210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52051">
        <property type="protein sequence ID" value="PHQ52051"/>
        <property type="gene ID" value="BLA24_09880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12208">
        <property type="protein sequence ID" value="PPT12208"/>
        <property type="gene ID" value="CYQ11_04210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="20711" checksum="27CAF9022C16A8C3" modified="2018-01-31" version="1">MPLHVPPAPAPALRCVRTALGSPTAVREARTPSLKSAQGPLSPELPLPVHVLERVTPRGGTPRTRLAGWRFLIKGGERAVAAGEAVPTPDGWAFSHFFEGPYLVSTELALRQAEALTTPYQPRLLSVPELYMLTLWLHADITAGASSELFAPGDLLVPLAPAPPGIAAHRPHRVTDLLPVLTLRLAPAPPLKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLJ9</accession>
    <name>A0A2G1XLJ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ureG</name>
        <name evidence="7" type="ORF">BLA24_09170</name>
        <name evidence="8" type="ORF">CYQ11_27780</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52086">
        <property type="protein sequence ID" value="PHQ52086"/>
        <property type="gene ID" value="BLA24_09170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16166">
        <property type="protein sequence ID" value="PPT16166"/>
        <property type="gene ID" value="CYQ11_27780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="6">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="24232" checksum="100DD755DC9E71F0" modified="2018-01-31" version="1">MHLDHPGAFPHRHTYSAAAPLRPDGSRRALRIGLGGPVGSGKTATVAALCRSLREELSLAVVTNDIYTREDAEFLLRHAVLPPERITAVETGACPHTAIRDDISANLEAVEDLEGAVGPLDLILVESGGDNLTATFSKGLVDAQVFVIDVAGGDDIPRKGGPGVTTADLLVVNKTDLAPHVGADLEGMARDARAQRGELPVAFTSLVATDGVAPVRDWVLARLADWTAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLL7</accession>
    <name>A0A2G1XLL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09430</name>
        <name evidence="3" type="ORF">CYQ11_28040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52132">
        <property type="protein sequence ID" value="PHQ52132"/>
        <property type="gene ID" value="BLA24_09430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16212">
        <property type="protein sequence ID" value="PPT16212"/>
        <property type="gene ID" value="CYQ11_28040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304781" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="13041" checksum="56AD0C278D7B637F" modified="2018-01-31" version="1">MLKKVLATAAVTASAVGAIASPAMAIGNDQDVANANGAKTGYGNTKTGGVESPQMSLIQGTLNKPCIGIGKLGIQSLIGALNIGLQDVPILTSQQQQQCTDNSTINDGDDPLSHLLDEIPILSGNGSANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLV6</accession>
    <name>A0A2G1XLV6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52196">
        <property type="protein sequence ID" value="PHQ52196"/>
        <property type="gene ID" value="BLA24_08480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="156" mass="16906" checksum="BB60F859001BDCAE" modified="2018-01-31" version="1">MCRLIRSIRWKRMEYVLGDAAPVLVVTSGAAAGKLPSVDGLVRVVVDDAAVVAELAELSGGELGAVERGGVVLPSHPAYVIYTSGSTGRPKGVVVPHQNVVRLFGGTDGWFDFGADDVWTWFHSFAFDFSVWELWGRTAPRWTSRCRSARCLPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLW0</accession>
    <name>A0A2G1XLW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08580</name>
        <name evidence="2" type="ORF">CYQ11_03835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52213">
        <property type="protein sequence ID" value="PHQ52213"/>
        <property type="gene ID" value="BLA24_08580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12146">
        <property type="protein sequence ID" value="PPT12146"/>
        <property type="gene ID" value="CYQ11_03835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="111" mass="11849" checksum="20163BBB750123E6" modified="2018-01-31" version="1">MAEPEFNATGVRIDRSHRSLTRAGQVKIKDGRLELLNSRGREIDSAPVEAVRAGKPWFAARDRARATATVNGTRYVLTLGGERSAAEDAGAATVSRFLEAVRSAHTGSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY7</accession>
    <name>A0A2G1XLY7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_08780</name>
        <name evidence="5" type="ORF">CYQ11_04040</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52247">
        <property type="protein sequence ID" value="PHQ52247"/>
        <property type="gene ID" value="BLA24_08780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12180">
        <property type="protein sequence ID" value="PPT12180"/>
        <property type="gene ID" value="CYQ11_04040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="263"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="495" mass="53044" checksum="D06EBACC59DABE1A" modified="2018-01-31" version="1">MAGTGSSPQGRRPASSLIWLVPPVVLALCTATAAYLVPSGARAPTIWCGTVATVVVALTSSEAVRRGRLIQLMRRQHNEREAALHHRLAQQEAETQRLARELLPAAVKMLQSGTTTDEVLREVSPVNLLDPSFAAAHRSVLRSVVEAVQAEEGLRESAHRAFVNIARRVQAIVHQQATDLREMEDRHGNNPDVFGDLLHLDHETALIGRLADSIAVLGGSRPGRQWKNPVPLYNVLRGAMSRIMDYRRVDLHSVADVAVVGPGVEPLIHALAELLDNATRYSPPQTRVHLTAVEVQSGVAVEIEDAGVGLTDEARRRTEAVLEVADRGLDLNDLGETPRLGLAVVSRLAKTYAFRVSLRPSAYGGVRAVLIVPENLVTASATPGGEIARAATLPPPKVRKKPGRPLPDLPFEIPEASRTSGGLPQRRRRAPGLAARGAPPATATAPASGSRRRPSTEPPPQPGMWLSAFTDAVNGEARPGDVGGQISDESSDKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM33</accession>
    <name>A0A2G1XM33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000091">
        <property type="protein sequence ID" value="PHQ52298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52298">
        <property type="protein sequence ID" value="PHQ52298"/>
        <property type="gene ID" value="BLA24_08440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="111" mass="11957" checksum="0787AF99C25022DB" modified="2018-01-31" version="1">MVLVDCLFSFWRHRHSLARLRELCATMPRTCLSAARRHLSGLSPHEHVLAAHLLADHSVVQNFPGVARRMAALADAGADCAMRLTGAVVDLDGLREARAEGPAGSGRTTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMC8</accession>
    <name>A0A2G1XMC8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="7" type="ORF">BLA24_08165</name>
        <name evidence="6" type="ORF">BLA24_10630</name>
        <name evidence="5" type="ORF">BLA24_10935</name>
        <name evidence="8" type="ORF">CYQ11_00615</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000127">
        <property type="protein sequence ID" value="PHQ51960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_031165262.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51953">
        <property type="protein sequence ID" value="PHQ51953"/>
        <property type="gene ID" value="BLA24_10935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51960">
        <property type="protein sequence ID" value="PHQ51960"/>
        <property type="gene ID" value="BLA24_10630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52402">
        <property type="protein sequence ID" value="PHQ52402"/>
        <property type="gene ID" value="BLA24_08165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11603">
        <property type="protein sequence ID" value="PPT11603"/>
        <property type="gene ID" value="CYQ11_00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="8495" checksum="B721E7E5BDDE8B16" modified="2018-01-31" version="1">MTKTSGGVEVEGTVVECLRNATFKVELQNGHTVLAHISGKIRKNYIKILPYDRVLVELSPYDLTRGRIRYRYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMI7</accession>
    <name>A0A2G1XMI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_06590</name>
        <name evidence="9" type="ORF">CYQ11_26740</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52448">
        <property type="protein sequence ID" value="PHQ52448"/>
        <property type="gene ID" value="BLA24_06590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15980">
        <property type="protein sequence ID" value="PPT15980"/>
        <property type="gene ID" value="CYQ11_26740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758885" evidence="5">
        <location>
            <begin position="27"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="50"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="242"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="391" mass="41231" checksum="D0DAD2922DD0AA84" modified="2018-01-31" version="1">MHVGPGRRPALLISALLGSLALTACGGSGGGSDAGPEAKVAVTPAGGGEAKLGSPISVKASDGRLTAVEVKDDKGQKIEGRLAEDGSSWTSNGKVKPKTTYTVHTTAKGGDKGKGKESSSTATFTTQQAEKVNKLTNTPANGDTVGTGMPVSILFDHAVAKDKRAEVEKAMQVTSEPKVEGAWGWVTDYSGQDRLDWRPKTFWPAGTKVSVKGALGGLESGEGRWFSRDYDFGFTVGADRKAVIDVPGHTLTMYENGKPVGDIKGSAGSPQDPTRGGIHTVRGKNAAETMDSATIGHGNEWMLDSKWVTYLTASGTFLHSAPWNKSIGVENNSHGCFGMTTADAKRAYDFLPIGATVEVKGTSSTKKTDVGNGLEVWQETWEQWQKRTALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMJ3</accession>
    <name>A0A2G1XMJ3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alaS</name>
        <name evidence="13" type="ORF">BLA24_06745</name>
        <name evidence="14" type="ORF">CYQ11_26895</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52475">
        <property type="protein sequence ID" value="PHQ52475"/>
        <property type="gene ID" value="BLA24_06745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16008">
        <property type="protein sequence ID" value="PPT16008"/>
        <property type="gene ID" value="CYQ11_26895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ52475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT16008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="882" mass="94752" checksum="38152160E1F985F9" modified="2018-01-31" version="1">MRTADIRSRFLDYFAARGHTVVPSAPLPTPDPTLLFVNAGMVPFKPYLTGEAAPPWPRATSVQKCVRTLDIEEVGRTTRHGSFFQMNGNFSFGDYFKEEAVSFAWELSTSSVEEGGYGLDPERIWATVHHSDDEAALLWRRVAGLPEERIVRRGDEDNFWSMGVPGPCGPCSELYYDRGPALGRAGGPAVDEDRYMEFWNLVFMQYERGEGAGKSGYPILGELPRRNIDTGMGLERMATLLQGVDNLYEIDETRPVLDRAAELTGVRYGADHLADVRLRVVADHVRTALMLLADGTAPGNEGRGYVLRRILRRAVRSVRLLGHQDPALPELLPAARDCMRHSYPEVAEEFGRISQQAYAEEDAFRSTLRQGTTVLDTAVAEVKAAGGHLLPGPKAFLLHDTYGFPVDLTLEMAEEQGVEVDREGFTALMAEQRERARADARARKSGGALDTSALRTVLAAHGPTDWRAYDTLTTDSRVLALLGPGGPLKAVRSGEIATVVLDRTPFYAESGGQDSDAGTLTGASVEAEVLDVQRPLPGLVVHRVRVTAGELAAGDAVRAAVDPEWRLGARQAHSGTHVLHAALRQVLGPTALQAGSYNRPGYLRLDFPWRGGLGPAARGEVEEAANRALRRDLPVDVRWMSLPEAKELGALALFGETYGERVRVVEIGGAWSRELCGGTHVERAAQVGVVALTAESSVGAGMRRLEAAVGFEGFRYLARERDLVSRLAEQVQAPRAHLPERVAGLLERLKAADQQAEELRRRAAVARAGELAAAATDVHGTLVVTATTDGDARSLALAVRDRLPRERPGVTAVGATADGGKAVLTIALNRAAAETGLSAAGLVKSLLSGRGGGTAEVAQGGGVPAESLRATLDGLTGLLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMM2</accession>
    <name>A0A2G1XMM2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1-antitrypsin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_06770</name>
        <name evidence="5" type="ORF">CYQ11_26920</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52478">
        <property type="protein sequence ID" value="PHQ52478"/>
        <property type="gene ID" value="BLA24_06770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16011">
        <property type="protein sequence ID" value="PPT16011"/>
        <property type="gene ID" value="CYQ11_26920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758514" evidence="2">
        <location>
            <begin position="28"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="37"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="421" mass="44713" checksum="CD5E9F89D9E76C87" modified="2018-01-31" version="1">MITTRRLAAGACALLAALAGGVAPANAADGPAKNSPKVELVLDVSGSMRAQDVDGGRRTRMAAAQQAFNEVIDATPENVRLGIRTLGASYAGEDKAIGCRDSQQLYRVGKVDRTDAKAAVAGLRPTGWTPIGYALRGADQDLGTDGGTRRIVLITDGEDSCGMPDPCDVARELAAKGTHLTIDTLGLTQDDKTREQLSCIAEATGGTYTTVRETKELSGRIKQLVRRAETPVETPKPVTGTDQCSTAPELRAGIWTDREKFSEHRWYRVKVKPGQELRASVSVGADRAVDRDYGVLLRAVTEGGQELVRGSDAGSGRTDVMAAGLRHPVAEAKDDGDKAPRTVCLEVSNSFSAPPSVQREPGLPVELAVDLVKGPDDPSDLAAFGLGRGWVLLAVLAVTGLLAGLLWGWLARWRLAVWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMP9</accession>
    <name>A0A2G1XMP9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06880</name>
        <name evidence="2" type="ORF">CYQ11_27030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52496">
        <property type="protein sequence ID" value="PHQ52496"/>
        <property type="gene ID" value="BLA24_06880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16030">
        <property type="protein sequence ID" value="PPT16030"/>
        <property type="gene ID" value="CYQ11_27030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="252" mass="28789" checksum="7129F804509F2607" modified="2018-01-31" version="1">MNLDVTPARLRLDRALDGLTVAFRGMTARPDESNCACHWGSAEELAQPKAPDGRLDADLLRRTWQAVDWKDHGAVLRRVLPQFSTALVRGLVEPGYGLEEAARSFARGHWQRWPARHSAAVWEFLHAWWAHTLTEPDPVVPAYEVLTFCAEASATMSPWLTAWEDARGPVADQHLAETADRWQDDMLCDELPWDAWENEEEMRTALATWLVTHGTARLRAHGVGEELLDRIQLLRLTGLARWEHPHWPFPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN19</accession>
    <name>A0A2G1XN19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_07325</name>
        <name evidence="12" type="ORF">CYQ11_27480</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52571">
        <property type="protein sequence ID" value="PHQ52571"/>
        <property type="gene ID" value="BLA24_07325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16109">
        <property type="protein sequence ID" value="PPT16109"/>
        <property type="gene ID" value="CYQ11_27480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304788" evidence="9">
        <location>
            <begin position="35"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="36"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="32722" checksum="D00F874C25C58FA9" modified="2018-01-31" version="1">MERSGRRTTRRWGVAVVASTAAVAVALPATAAEAASGPSGVAAKGAFLLDSGADRTLWSKDADTRRQMASTTKIMTAVTVLDTRGVDLNKKVTIKQSYRDYVTRNGASTADLRTGDVMTVRQLLYGLMLPSGCDAAYALADTFGTGSTEAARTKSFIGKMNKTAADLGLKNTKYDSFDGISQAGNNYTTPRDSAKLARHALANGTFATVVKATATRQKAANVNRTYYWDNTNKLLGSYKGAIGIKTGTGTAAGPCLVFAAQRGKRTVVGVILNDPANRYPDAAKMLDWAFDTKTTVKLRQLPPSAQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN53</accession>
    <name>A0A2G1XN53_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_06015</name>
        <name evidence="7" type="ORF">CYQ11_03540</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52658">
        <property type="protein sequence ID" value="PHQ52658"/>
        <property type="gene ID" value="BLA24_06015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12092">
        <property type="protein sequence ID" value="PPT12092"/>
        <property type="gene ID" value="CYQ11_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="328" mass="34601" checksum="24045BE873E0C7C6" modified="2018-01-31" version="1">MTVSTSRTALRAEGLVKNFGSVRALDGVDLELPAGKVLGLLGPNGAGKTTSVRVLATLLRPDGGRAWVNGHDVLAEPHKVRQSIGLSGQFTAVDESLTGYENVVMFARLSGLSKADSVERANQLVDRFGLRHAASRPPKTYSGGMRRRLDLASALVGNPAVVVLDEPTTGLDPRGRLDTWEQVGELVSDGTSVLLTTQYLEEADHLADSIAVIDHGRVIAHDTADRLKTQIGADKIKAVVADPADLPRLKSVLAEVGTAAPSVEESSRAATVTVTTGVKALMAAIQRLEAEGIELVDIGLQRPSLDDVFLSLTGKSEQDASRAPQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNC8</accession>
    <name>A0A2G1XNC8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_06020</name>
        <name evidence="10" type="ORF">CYQ11_03545</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52659">
        <property type="protein sequence ID" value="PHQ52659"/>
        <property type="gene ID" value="BLA24_06020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12093">
        <property type="protein sequence ID" value="PPT12093"/>
        <property type="gene ID" value="CYQ11_03545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="13"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="29135" checksum="6065543C4447875C" modified="2018-01-31" version="1">MSNVAEAVRSSTIITRRNLLHIWREPGALISHLCTSIMFVVLFAFVIGGGLGAAYPEYLIPGMLGQNAVFVNIYTTVGLAYDMEKGIVDRFRSLPISRAAVLFGRTSSDLFATAMNLAILSLCGLLIGWRVRTDVFSAIGAYGLLLLFAFAISWAGAYIGLLCRRVELAQSAGIIWVFPFTFMSSALVGSQYMLQPFKFIAEWSPLTALCDTIRDLFGNPYPEDFPKGSSWAAHNSALYCTLWCLGLLAVFVPLTVRRYRKLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNK0</accession>
    <name>A0A2G1XNK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05985</name>
        <name evidence="3" type="ORF">CYQ11_02460</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52808">
        <property type="protein sequence ID" value="PHQ52808"/>
        <property type="gene ID" value="BLA24_05985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11910">
        <property type="protein sequence ID" value="PPT11910"/>
        <property type="gene ID" value="CYQ11_02460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="23349" checksum="DB21691F770BEA1E" modified="2018-01-31" version="1">MGTTARDRETVRALLRTHGRTYAEEAGIRLRDTPQPLYRLLVLACLLSARIRASVAVATARSLAEAGLKDPRRMAEAGWQRRVDALGEGGYRRYDERTATQLGDGARLLLDDYGGDVRRMRKKADGDPGALRSVLQEIPGLGPAGADIFLREVQGVWPEVFPRFDGKALQGAGRLGLPTEPAGLARLVEREEAPALAAALVRAALDEAVADDVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP84</accession>
    <name>A0A2G1XP84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF488 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04700</name>
        <name evidence="2" type="ORF">CYQ11_28830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52969">
        <property type="protein sequence ID" value="PHQ52969"/>
        <property type="gene ID" value="BLA24_04700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11517">
        <property type="protein sequence ID" value="PPT11517"/>
        <property type="gene ID" value="CYQ11_28830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="13648" checksum="337CF0B609119835" modified="2018-01-31" version="1">MARERRVRVRRVYDPPEGTDGSRVLVDRLWPRGLSKEKAALDEWCKDAAPSPELRKWYGHDPERFEEFSRRYRAELDDAAHADAVAHLRQLAARGPLTLLTATGQWEISAAAVLLDALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPB2</accession>
    <name>A0A2G1XPB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000052">
        <property type="protein sequence ID" value="PHQ53077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53077">
        <property type="protein sequence ID" value="PHQ53077"/>
        <property type="gene ID" value="BLA24_03725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="98" mass="10167" checksum="F04EFE7E74954D73" modified="2018-01-31" version="1">MIRQNTSNPGDGAVTRPHALLLQGVFEAAGVATEIVPTPKQDNVHFLARVPAARPGGKKPLLLLGHSDVVPATGDTWTVEPFAGLVKDGMLYGGAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPC4</accession>
    <name>A0A2G1XPC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_03680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000051">
        <property type="protein sequence ID" value="PHQ53088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53088">
        <property type="protein sequence ID" value="PHQ53088"/>
        <property type="gene ID" value="BLA24_03680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="66" mass="7520" checksum="DA5B35B2D7047E70" modified="2018-01-31" version="1" fragment="single">MRLIVAAFQDVPEETWGRSAGELEWDCWETVEHLADDMFCYALQLSAPNPPLDSYVPTLMTCQRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPP9</accession>
    <name>A0A2G1XPP9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_02340</name>
        <name evidence="12" type="ORF">CYQ11_04705</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53196">
        <property type="protein sequence ID" value="PHQ53196"/>
        <property type="gene ID" value="BLA24_02340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12288">
        <property type="protein sequence ID" value="PPT12288"/>
        <property type="gene ID" value="CYQ11_04705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="221"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="283"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="359" mass="38172" checksum="95F6E94AF70DD605" modified="2018-01-31" version="1">MSVLQLLFAVALVLANGFFVGAEFALVSVRRSQIEPKAAAGSGRARTVLTGLENLPQMMAAAQFGITVCSLTLGAVAEPTVAALLEPVFHAVGLPEGLIHPLGYVIALALVVFLHLVIGEMVPKNLAMSAPDRAALWLGPGLVGFARLCRPVTRLLGACAHGVLRLFRVEPKDEVEAVFTSEQLTHLVEDSGQAGLLGPAEQERLSDALELGSRPVTDVLLDPATLVTVDPSVTPREVEELTVKTGYSRFPICASPGGSFMGYLHVKDVLDLEDADRAVPQHVWRRVETLRAELPLDDALTVMRRAAAHLAAVTDASGRMLGLVALEDVLEMLVGEVRDPAHRVVPVARHAEEQGALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ02</accession>
    <name>A0A2G1XQ02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SsgA family sporulation/cell division regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_03000</name>
        <name evidence="5" type="ORF">CYQ11_05300</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003959770.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XQ02"/>
    <dbReference type="EnsemblBacteria" id="PHQ53293">
        <property type="protein sequence ID" value="PHQ53293"/>
        <property type="gene ID" value="BLA24_03000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12390">
        <property type="protein sequence ID" value="PPT12390"/>
        <property type="gene ID" value="CYQ11_05300"/>
    </dbReference>
    <dbReference type="GeneID" id="58431150"/>
    <dbReference type="GeneID" id="63978789"/>
    <dbReference type="GeneID" id="66959955"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14838" checksum="753EE7C6483CA9F6" modified="2018-01-31" version="1">MNTTVSCELHLRLVVSSESSLPVPAGLRYDTADPYAVHATFHTGAEETVEWVFARDLLAEGLHRPTGTGDVRVWPSRSHGQGVVCIALSSPEGEALLEAPARALESFLKRTDAAVPPGTEHRHFDLDTELSHILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ25</accession>
    <name>A0A2G1XQ25_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argC</name>
        <name evidence="8" type="ORF">BLA24_03195</name>
        <name evidence="7" type="ORF">BLA24_30060</name>
        <name evidence="9" type="ORF">CYQ11_05495</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000165">
        <property type="protein sequence ID" value="PHQ48406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48406">
        <property type="protein sequence ID" value="PHQ48406"/>
        <property type="gene ID" value="BLA24_30060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53323">
        <property type="protein sequence ID" value="PHQ53323"/>
        <property type="gene ID" value="BLA24_03195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12420">
        <property type="protein sequence ID" value="PPT12420"/>
        <property type="gene ID" value="CYQ11_05495"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="342" mass="34832" checksum="0EA0B3AC6D3E9A68" modified="2018-01-31" version="1">MAIHAAVAGASGYAGGEVLRLLLAHPEVRIGALTGNSNAGQRLAALQPHLPPLADRVLEATTTEALAGHDVVFLALPHGQSAEVAERLGDDVLVIDCGADFRLRDAGDWERFYGSPHAGTWPYGLPELPGARQALRGAKRVAVPGCYPTAVSLALFPAYAAGLAEPEAVIVAASGTSGAGKAAKPHLLGSEVMGSMSPYGVGGGHRHTPEMVQNLSAVAGEPVTVSFTPTLAPMPRGILATCSTKARPGVTAQAVRAAYEKAFQDEPFARLLPEGQWPATASVYGSNTALVQVALDEAAGRIVAVAAIDNLTKGTAGGAVQSMNLALGLPEELGLPATGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ58</accession>
    <name>A0A2G1XQ58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01665</name>
        <name evidence="3" type="ORF">BLA24_01700</name>
        <name evidence="1" type="ORF">BLA24_25720</name>
        <name evidence="4" type="ORF">CYQ11_20350</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000029">
        <property type="protein sequence ID" value="PHQ53362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000029">
        <property type="protein sequence ID" value="PHQ53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49442">
        <property type="protein sequence ID" value="PHQ49442"/>
        <property type="gene ID" value="BLA24_25720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53362">
        <property type="protein sequence ID" value="PHQ53362"/>
        <property type="gene ID" value="BLA24_01665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53369">
        <property type="protein sequence ID" value="PHQ53369"/>
        <property type="gene ID" value="BLA24_01700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14908">
        <property type="protein sequence ID" value="PPT14908"/>
        <property type="gene ID" value="CYQ11_20350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="94" mass="10087" checksum="B842A24525AF3B22" modified="2018-01-31" version="1">MKHSEKALANGWGWVLGVSGEECRVYSRPAQQAPAEDPAELLGRVTKLLGLDDPSQVPAAIRTLQEDRKKALASAATAWNAVHELTRRPSGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQD9</accession>
    <name>A0A2G1XQD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02234 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00540</name>
        <name evidence="4" type="ORF">CYQ11_07550</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53454">
        <property type="protein sequence ID" value="PHQ53454"/>
        <property type="gene ID" value="BLA24_00540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12759">
        <property type="protein sequence ID" value="PPT12759"/>
        <property type="gene ID" value="CYQ11_07550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019051">
        <property type="entry name" value="Trp_biosyn_TM_oprn/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011746">
        <property type="entry name" value="Trp_synth-assoc_CHP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09534">
        <property type="entry name" value="Trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02234">
        <property type="entry name" value="trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="21947" checksum="D2EBCB7E526A04CD" modified="2018-01-31" version="1">MSAAVPHPRTHAEPTPREDRGGRRSVAAALLLGAAGAALVLLSGGRTWSEGTAADVAQASAVQHASGQDVTALPGALAIVGLAALVAVFAVRRAGRLVVAGLLALSGAGVVASAVTALSDTAALEEKAAKASGLTRAGVEGVTHTAWPWVAVAGGVLLLLAGLLALRHGRDWPAMSGRYERDGAPRPRPRTAPDPDRPEELWKALDRGEDPTGGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQK6</accession>
    <name>A0A2G1XQK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00925</name>
        <name evidence="4" type="ORF">CYQ11_07935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53525">
        <property type="protein sequence ID" value="PHQ53525"/>
        <property type="gene ID" value="BLA24_00925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12830">
        <property type="protein sequence ID" value="PPT12830"/>
        <property type="gene ID" value="CYQ11_07935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="292"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="41256" checksum="85EE91EF05C655A7" modified="2018-01-31" version="1">MSVELPLWRALTGYRILTLGYALALFFLNYHEYAHPLGAALYMGVLTLWMLLTWNRVSAPERCTRAFLIADLTIALAGVLLSAVVDSAQRVDGGAATLPSIWTGGAVLGLAIKGGWRWAAAGSTLVAAANLVERGSAARDTVHNVVLVWVSSIAIGYIVEVARASERTLARALQIEAATRERERLARDIHDSVLQVLAMVQRRGAAIGGEAAELGRMAGEQEIALRSLVAGGLVPPQRSAEQLAEDAELVEAVTGAPRPPVGPCDLRALLAPHEGATVTFSAPGTPVLLEAAAAAELAAAVSAALDNVAKHAGAGARAWILVEDEPDGVIVTVRDDGPGIPEGRLADAEREGRMGVALSIRGRLRDLGGTAELVSVPGQGTEVELRVPRGSEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQM7</accession>
    <name>A0A2G1XQM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenazine-specific anthranilate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00910</name>
        <name evidence="4" type="ORF">CYQ11_07920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53522">
        <property type="protein sequence ID" value="PHQ53522"/>
        <property type="gene ID" value="BLA24_00910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12827">
        <property type="protein sequence ID" value="PPT12827"/>
        <property type="gene ID" value="CYQ11_07920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="126"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="449"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="653" mass="69945" checksum="438AC7915BFD6B4F" modified="2018-01-31" version="1">MTAGTAALLARLTDPGCPPFALLHRRTPGHPEDVVELLTGPVTEVERLAAIPLPDGPPPHGRPVHDALALVPFRQIRERGFDVRDDGTPLLVLRPEEVHELPLDDVLAALPRHEVRVEGGAFDMSDDDYARVVQRVVEDEIGTGEGADFVIRRTFEGEVHGFRAADALALFRRLLAGERGAYWTHVVHTPGRTLVGASPEVHVRMAGGTVVMNPISGTYRHPAGGPTAEGLLKFLHDPKEVEELSMVVDEELKMMCTVGDMGGVVVGPRLREMAHLAHTEYELRGRSSLDVRDVLRETMFAATVTGSPVQNACRVIERYEPRGRGYYAGALALLGRDAGGAQTLDSPILIRTADIGGDGRLRLGVGATLVRRSDPRAEVAETHAKAAGVLTALGVRPGPLRPAAAPAVRLADDPRVRAALDARRADLAPFWLRMQTEPRAAATSGHALVVDGEDTFTAMLAHVLRTAGLTVTVRRFDEPGLREAALAHEGPVVLGPGPGDPSDTADPKMRMLRSLTGELLRGHRHGPAATTPQQGTAGRVLFGVCLGHELIAAELGLGIVRKRVPFQGAQERIDFFGRQETVGFYNTFTARCDAATAVELATRGVELSRDPESGDVHALRAGTFAGVQFHPESVLTLNGVAVVSELLAGVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQP5</accession>
    <name>A0A2G1XQP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01020</name>
        <name evidence="3" type="ORF">CYQ11_08030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53542">
        <property type="protein sequence ID" value="PHQ53542"/>
        <property type="gene ID" value="BLA24_01020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12847">
        <property type="protein sequence ID" value="PPT12847"/>
        <property type="gene ID" value="CYQ11_08030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="9933" checksum="8695DCD0FA543EFA" modified="2018-01-31" version="1">MITSIVLIKTDVDRIPEIAESIAALEGVSEVYSVTGACDLIALVRVARHDDLADVIPGRISKVPGVASTETHIAFRTYSQHDLEAAFAIGLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQR4</accession>
    <name>A0A2G1XQR4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000007">
        <property type="protein sequence ID" value="PHQ53585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53585">
        <property type="protein sequence ID" value="PHQ53585"/>
        <property type="gene ID" value="BLA24_00175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="122" mass="14011" checksum="100287D0433B90C5" modified="2018-01-31" version="1">MRRRDRRALPEVAGENGKTFKVSAAPTSLRERRPRPRVAFCSTTSERLRLRARHEASTDDLYKFVDTSRLRRLHRPGLEQFTPYYYQAGTELGSPSPKFAHLKACCAIPTATSRHLRPLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9E1</accession>
    <name>A0A2G1X9E1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4192 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30460</name>
        <name evidence="3" type="ORF">CYQ11_23555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47838">
        <property type="protein sequence ID" value="PHQ47838"/>
        <property type="gene ID" value="BLA24_30460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15463">
        <property type="protein sequence ID" value="PPT15463"/>
        <property type="gene ID" value="CYQ11_23555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="507" mass="54020" checksum="39E04A66F5F5A7B7" modified="2018-01-31" version="1">MTQHNESTQPSAVSPATWESRPETQITLRSPAELADALPYLMGFHPTDSVVLLALHGERGRFGGRLRLGIPASREEWPEVSAQLAETLVAGSGTRGTRPDGIVLFLCQDPTGEETGREVMERLRPFAQSLRLACGGLDVPVYEALCLSGGRFWSYCCPDERCCSPDGTPLALPGTSVMAAAAAYAGIRVRGTLREMENRYAPLTGARAQEQESALDAAASDLVPRLLTGVNVETVRQETLDLARLVVARFHETPPPAVQADADAMDDTLLACDEAAAIILGLQDRTTRDHAAEWMEGPQAPATLRVWRALARRCVPPYTEHAAAPLTLAGWVAWSTGDQPEARVALSQALTADSEYLFAQLLHRACNEGMDPELLRRCLRREHAGRAVQDTPRVEEDRAAGTDRTEDPLVPDAAVGTRAAPGREDTGAPEAAADRGATAGPGVAPGTDAGRTVGGCPETTERAPAESVGRRPRVAGSRPSGPAGANGPAGRSRTRRRPGPRGVRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9N8</accession>
    <name>A0A2G1X9N8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">kdpB</name>
        <name evidence="15" type="ORF">BLA24_30700</name>
        <name evidence="16" type="ORF">CYQ11_23795</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47879">
        <property type="protein sequence ID" value="PHQ47879"/>
        <property type="gene ID" value="BLA24_30700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15504">
        <property type="protein sequence ID" value="PPT15504"/>
        <property type="gene ID" value="CYQ11_23795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ47879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT15504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="702" mass="73970" checksum="6B89B2E4387E296C" modified="2018-01-31" version="1">MSTTTPVRTEPEGPADDRPQGGEEHGRVSGGLFDPAQLLKSLPDAFRKLDPRVMVKSPVMFVVLIGSVVTTALALRHPGEWFGWAITVWLWLTVLFANLAEAVAEGRGKAQADTLRKAKTDTVARRLNGDTEESVPGTELRVGDLVVCEAGDVIPGDGDVVEGVASVDESAITGESAPVIRESGGDRSAVTGGTKVLSDRIVIKITTKPGETFIDRMINLVEGAARQKTPNEIALNILLASLTIVFLLAVITLQPFAIYAGAEQSMIILAALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVSTLLLDKTGTITYGNRQASEFVPVKGTMAAEVADAAQLSSLADETPEGRSIVVLAKEKYGLRERHEGELVGAEWVPFTAQTRMSGVDVEGRKVRKGATGSVIAWVEEQGGTVAEDARKLTDDISQAGGTPLLVALEDDKGARVLGVIHLKDVVKEGMRERFDELRAMGIKTVMITGDNPLTAKAIAEEAGVDDFLAEATPEDKMALIKREQAGGKLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMVDLDSNPTKLIEIVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFAVAYPGLDKLNVMGLTSPESAILSAVIFNALIIVALVPLALKGVRYRPMSADSMLRRNLGIYGLGGLIAPFIGIKLIDMLISLIPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9N9</accession>
    <name>A0A2G1X9N9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional salicylyl-CoA 5-hydroxylase/oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31310</name>
        <name evidence="4" type="ORF">CYQ11_24350</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47954">
        <property type="protein sequence ID" value="PHQ47954"/>
        <property type="gene ID" value="BLA24_31310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15578">
        <property type="protein sequence ID" value="PPT15578"/>
        <property type="gene ID" value="CYQ11_24350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="386"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="749" mass="82049" checksum="01CB0CA698A39825" modified="2018-01-31" version="1">MTAARVAVIGGGPGGLYAAALLKRHDRRRDVTVWERNAPDDTFGFGVVLSDETLGGLETADPAVSAAIGEEAVRWDDIEVVHRGSRLVSGGHAFAALGRHRLLELLHERCRTLGVTLRFRTEAPPAAELVRSHDLVIAADGVHSRTRRSHRDVFRPTLTPHRCRYIWLAAGFALDAFRFEIAETEHGIMQLHAYPFSPRASTVIVEMREEVWRRAGLDRCDEEETLRSCGKHFSGLLDGRPLRTNRSAWTVFCTVVNERWSHGRTVLLGDAAHTAHFSIGSGTKLAVEDAVALVRHLDRTPAVPEALAAYEAERRPVVESTQRAARASLEWFEDLAHHVGRPPHRFAFDLLTRSRRVTHDNLRLRDAGFVTAVEKEAGIPAGTPPMFTPFRLRGLTLRNRVVVSPMDMYSAVDGTPGDFHLVHLGARALGGPGLVMTEMVCVSAHGRITPACAGLYAPEHERAWRRVTDFVHQQAPGTAIGVQLGHSGRKGSTRRMWEGIDQPLPEGNWPLVAASALPYRPGVSQTPHALTPGELADLREQFARSAQAAARAGFDLLELHCAHGYLLSGFLSPLTNHRDDAYGGDLPRRLAFPLEVFDAVRAVWPAERPMTVRISATDWAEGGTTAEDAVTVARAFADHGADAVDVSTGQVVPDERPAYGRSYQTPFADRIRQEAGVPVIAVGAISSWDDVNSLILAGRTDLCALGRPHLYDPNWTLHAAAEQEYSGPGVHWPVQYRAGSRKPPTGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9V3</accession>
    <name>A0A2G1X9V3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sulfate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_31740</name>
        <name evidence="7" type="ORF">CYQ11_24795</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48027">
        <property type="protein sequence ID" value="PHQ48027"/>
        <property type="gene ID" value="BLA24_31740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15653">
        <property type="protein sequence ID" value="PPT15653"/>
        <property type="gene ID" value="CYQ11_24795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="294" mass="31080" checksum="8728EEA1D6B9E952" modified="2018-01-31" version="1">MAATDTTRTTEPDLAGLEAGLDALDTVQVGRTPLRQVLLHKVLPPVVAVALVLTVWKLLVLAGVTDDYKLPDPTAVWRSLRELWLQGTLFDIIWTSVSRGLLGFLAALALGTPLGLLIARLPLLRAALGPLLSGLQSLPSVAWVPAAVIWLGITDTAMYAVILLGAVPSIANGLVSGIDQVPPLYLRAGRTMGATGLHGTRHVLLPAALPGYVAGLKQGWAFSWRSLMAAELIASSPELGLGLGQYLENARTDSDMPGVLLGIILILLVGIAIDLAVFSPLERRVLRARGLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9W0</accession>
    <name>A0A2G1X9W0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_31605</name>
        <name evidence="13" type="ORF">CYQ11_24655</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48003">
        <property type="protein sequence ID" value="PHQ48003"/>
        <property type="gene ID" value="BLA24_31605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15629">
        <property type="protein sequence ID" value="PPT15629"/>
        <property type="gene ID" value="CYQ11_24655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="118"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="390"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="689" mass="74160" checksum="6EDEE6F51983B547" modified="2018-01-31" version="1">MVERDNGTGAHKPSASAHGRRRRPPARRFSLPRLRPPRFDAARLRPAYPRPGRTGYRRWVPSWRQALGLFGLVFGTLTAIVMILYARTEIPADLNAFATQQDNVYYWADGTEMARTGPVDRQDTALEKVPEKVRWAALAAENETFYSDSGVSPSGMMRAVTRMVTGGDTQGGSTITQQYVKNAYLNQQQTFSRKLTEAFIAIKLDNRMSKDDILEGYLNTSWFGRGTYGIARAAHAYYDKDVSQLNASEGAFLASLLKGAALYDPAVGAKNHERAVERWKWILDRMVSTGKLSAEERARYTTFPEPKAPPKPVNLTGQTGYLVDTARAYVSAHTNVSDADFDLGGYQIRTTFEKPRVEALAKAVDGARAHLDPDEREADQNVRIGAASVATDGRIVALYGGPDYLKQGFNDANSTVVPAGGAFTPFVYAAALRDGIQRERGATRTPVTPATLYNGDNKVAIRTPEGPYWDRSGKIVKALNDDSKSWGRITLKEAVAQSVNSPMMQLGMDVGLDRVSRTAVGAGLLPESLGPQVPAFSLGTSTPSAIRMAGAYATFAAKGMHSEPYSVGSLRRNGDAVEVEKPTAERALPAGVATSVDDALHEAVKRGSATAAKAAGPDAAGKTGTGPDNKSAWFAGYRGKVSTAVSLTRIDPKTQELLPLDGLGGAPKTATGSPYPIDIWTACMAKTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA46</accession>
    <name>A0A2G1XA46_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ribose ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_32180</name>
        <name evidence="8" type="ORF">CYQ11_25235</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48100">
        <property type="protein sequence ID" value="PHQ48100"/>
        <property type="gene ID" value="BLA24_32180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15725">
        <property type="protein sequence ID" value="PPT15725"/>
        <property type="gene ID" value="CYQ11_25235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="344" mass="36463" checksum="F3F984724EFD504A" modified="2018-01-31" version="1">MSADAITDERLIGRSPLRRLLGRPELGAVVGAAAVFLFFSFAADSFLRASSLSTVLYASSTIGIMAVPVALLMIGGEFDLSTGVMVTTSALVSSMVSYQMTANVWVGVGVSLLATLAVGFFNGFMLTRTKLPSFIITLGTFLMLTGLNLGFTKLVSGTVSTKTIGDMEGFESARTLFASHLTIGDVDLQVTILWWFGLVALATWILLRTRVGNWIFAVGGGADAARAVGVPVNKTKIGLYMAVAFCAWISGQHLLMSYDVVQSGEGVGNEFLYIIAAVIGGCLMTGGYGSAIGSAVGAFIFGMTSKGIVYAQWNPDWFKFFLGGMLLLATLLNAWVRKRAEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA79</accession>
    <name>A0A2G1XA79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32485</name>
        <name evidence="3" type="ORF">CYQ11_25535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48147">
        <property type="protein sequence ID" value="PHQ48147"/>
        <property type="gene ID" value="BLA24_32485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15773">
        <property type="protein sequence ID" value="PPT15773"/>
        <property type="gene ID" value="CYQ11_25535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="242" mass="26751" checksum="C997167C195D3D89" modified="2018-01-31" version="1">MSSVFGQCESLRERCEIGSVQLSHGEADYDEGAILPAGDWRPLNVGEAQQFEAEPGTPDGALIELVRQPLPVMRPEEAPDIRTTAAALYPFADRWPADFLGCVTDPGDERTTTEDPATGRRLGLHVDNWDRLPYGARGDGRRRLCLNLGPGVRYFLLGDRDIEEIYQCVHPDPAHHYPHTDDVRRYVTQGRPLQCLRIRLDPGDGYLTPTELLPHDGSTRGGEQPSTAAFWPGRWPGGAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAH1</accession>
    <name>A0A2G1XAH1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">galE</name>
        <name evidence="9" type="ORF">BLA24_33005</name>
        <name evidence="10" type="ORF">CYQ11_26055</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48237">
        <property type="protein sequence ID" value="PHQ48237"/>
        <property type="gene ID" value="BLA24_33005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15864">
        <property type="protein sequence ID" value="PPT15864"/>
        <property type="gene ID" value="CYQ11_26055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="328" mass="34776" checksum="BF30D576D36B49BB" modified="2018-01-31" version="1">MTWLITGGAGYIGAHVARAMTEAGERVAVLDDLSSGVAARLPAGTPLVRGSVLDRAVLDRAFAELDVTGVVHLAAKKQVGESVEKPLLYYRENLHGLTVLLEAVVAAGVGSFVFSSSAAVYGMPDVDLVTEDTPCLPINPYGETKLAGEWLVRATGAAHGISTACLRYFNVAGAARPELADTGVFNIIPMMFDRVTRGERPRIFGTDYATPDGTCVRDYIHIEDLATAHLAAARRLAGRPGAGDLTLNVGTGQGVSVREMADLIAEVTGRPGLTAETGPRRPGDPARVVASGKRIAEELGWSATHDLRSMVTSAWEGWCLHHPEARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAI0</accession>
    <name>A0A2G1XAI0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">BLA24_33080</name>
        <name evidence="6" type="ORF">CYQ11_26130</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48247">
        <property type="protein sequence ID" value="PHQ48247"/>
        <property type="gene ID" value="BLA24_33080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15877">
        <property type="protein sequence ID" value="PPT15877"/>
        <property type="gene ID" value="CYQ11_26130"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="387" mass="40865" checksum="7E2AC656B10AD691" modified="2018-01-31" version="1">MATTEPLSLGVPQVPARLAVRRPSRRIQVGSVPVGGDAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIKQFDDKVKEIAKAASDAGTPIRIGVNAGSLDRRLLQKYGKATPEALVESALWEASLFEEHGFRDIKISVKHNDPVVMVNAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPAEEIKVGIQILESLNLRQRRLEIVSCPSCGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAEQMEAEGALSGPPAVTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAR7</accession>
    <name>A0A2G1XAR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33430</name>
        <name evidence="3" type="ORF">CYQ11_26480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48305">
        <property type="protein sequence ID" value="PHQ48305"/>
        <property type="gene ID" value="BLA24_33430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15936">
        <property type="protein sequence ID" value="PPT15936"/>
        <property type="gene ID" value="CYQ11_26480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="33219" checksum="7CE6429611AE7D8E" modified="2018-01-31" version="1">MSLHVVIGFGPAGAATARLLAGRGHAVRVVTTSGRPPEPGIEHIALDATDGKRLAEAARGATAIFSCAAPPYHRWPGQWPPLASSLCAAAEATGAVLVMLGNLYGYGPVDGPLTEDLPLAATGPKGRVRAAVWERARALHDQGRIRAVEVRASDFFGPGVTDGGHLAARVVPRLLRGKPVSTLGDPDAPHSWSYLPDVAGALVEVAGEERAWGRPWHVPTEPPRSVREMTGLLAAQAGTGPVAVRGTPPAVLGVASLFSPLIRELKEIRYQFDRPFILDASAYASAFTLRATPVDQQVKATVDWWRERLAAGGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAR8</accession>
    <name>A0A2G1XAR8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">BLA24_31255</name>
        <name evidence="8" type="ORF">CYQ11_24295</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48337">
        <property type="protein sequence ID" value="PHQ48337"/>
        <property type="gene ID" value="BLA24_31255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16761">
        <property type="protein sequence ID" value="PPT16761"/>
        <property type="gene ID" value="CYQ11_24295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="19454" checksum="B0570256F7A63E7D" modified="2018-01-31" version="1">MGRCHPIRTSGVSFSLTGACSSLESRDVHSQHVPRRGDPVNRSEATDEQWEGLAEVVPLRGHQAWPSWPDHRALPEEEPERDRRRLVVLRVQVFADAREVAEHLIARVPVLLDLTSADIDVAKRILDFSSGVVFGLSSAMHRVDTNVFLLAPEGTEVGSGYPDRRKNDQLKRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAS2</accession>
    <name>A0A2G1XAS2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_33465</name>
        <name evidence="6" type="ORF">CYQ11_26515</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48312">
        <property type="protein sequence ID" value="PHQ48312"/>
        <property type="gene ID" value="BLA24_33465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15943">
        <property type="protein sequence ID" value="PPT15943"/>
        <property type="gene ID" value="CYQ11_26515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758451" evidence="3">
        <location>
            <begin position="31"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="4">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="34532" checksum="DB936E4BE072D4D2" modified="2018-01-31" version="1">MRTRHQAVRTSLLGLAPLTLTVLTAGPAGAHGSLTDPVSRVSACFAEGPEHPRSAACKAMVAAGGTQPLYDWNEVNIGDAAGRHRRIIPDGKLCSAGREKYKGLDLPRADWPGSKLAPGTHTFRYRATAPHRGTFELYVTKDGYDPKKPLTWSDLEAKPFAKVTDPALKDGSYVFRGTVPKKSGRHLIYSIWQRSDSPEAFYTCSDVDFGGSGPSAAQAPAASAPSDRQITDEAGRSTVDHGGHGGDGKDAHAGTHGQDAREGHAAPAAAEDAGTRATGVTTANAPAAQGGKLAETGGRGSTTTLAVAGAGTLAVGAVALLLAARRRAARNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAV0</accession>
    <name>A0A2G1XAV0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32325</name>
        <name evidence="6" type="ORF">CYQ11_25375</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48367">
        <property type="protein sequence ID" value="PHQ48367"/>
        <property type="gene ID" value="BLA24_32325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16793">
        <property type="protein sequence ID" value="PPT16793"/>
        <property type="gene ID" value="CYQ11_25375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="25713" checksum="D6DB643532FA7F6B" modified="2018-01-31" version="1">MAAPDTVNPRRAGDTGTPLVVCENAARTYGKGPGAVVAVHGLTCAVEPGTRVCVVGPSGSGKSTLLHLMAGLDRPTAGRVSHPGLGGEHAESLARHIGVVFQGPSLLPPLTAAENVALPLRIDGVPEGEADTRAYAALESLGLQALAPRLPDELSAGQAQRVAVARVLARRPRLVLADEPTGQLDRATGRQVLSVLLGAARELGAAVLVTTHDPRVARELDVRWYMADGCLVQPDAEAGPNPHPAGRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB14</accession>
    <name>A0A2G1XB14_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_29115</name>
        <name evidence="13" type="ORF">CYQ11_06360</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48437">
        <property type="protein sequence ID" value="PHQ48437"/>
        <property type="gene ID" value="BLA24_29115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12567">
        <property type="protein sequence ID" value="PPT12567"/>
        <property type="gene ID" value="CYQ11_06360"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="40691" checksum="09E56E605CFF3382" modified="2018-01-31" version="1">MTSLASRSGTAPAPASAPGGAAASPAAPRRAVAALLLYAGVRALGVVVLALWGLADGKGPLRLLSARWDSLWYARIAEDGYGYTLHLAGGKVHSDMAFFPLLPWLERGLSAVLPLSAGEAGLVVSAVAGLFAAWGIFAVGECLHGRRAGLALVGLWAALPVGIVASMAYSEALFTALAAWSAYCVLTGRWVGAGSLAALAGLTRPVGAAVVAAVWITAAVTLLRRHRRGERGAPPLRLLLGVLLAPLGWLAYFAWVGVRTGSVTGYLDVQGGWGNGFDGGLAFGSFIGERLAGPAWPAGIALLAGVALVVWLYVAGARRGQPLPLLVFSGTVLLLALTAKGYFGSKPRLMMPAFPLLLPPAVALARLRTVRAAAVLTTVALASAVYGAFWLHGSGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBR9</accession>
    <name>A0A2G1XBR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sufD</name>
        <name evidence="2" type="ORF">BLA24_28465</name>
        <name evidence="3" type="ORF">CYQ11_07005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48651">
        <property type="protein sequence ID" value="PHQ48651"/>
        <property type="gene ID" value="BLA24_28465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12669">
        <property type="protein sequence ID" value="PPT12669"/>
        <property type="gene ID" value="CYQ11_07005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="393" mass="41987" checksum="0F2E3E668316A8F7" modified="2018-01-31" version="1">MADNTPAGSTTDGAIQVGGPRQPIDARVSAPASYDVADFPVPHGREEEWRFTPLERLRGLHDGTAVADGAGVKVEVTAPEGVTVETVGRDDARLGRSGKPVDRVAAQAYSSFEKASVVSIPKDTVLSEPVRISVRGEGGVAFGHQVVEIGAFSEAVVVIDHTGDATLAANVEYLLGDGAKLTVVSVQDWDDTAVHAAQHTALVGRDASFKSVIVTFGGDLVRLHPRVVYGAPGGEAELYGLYFTDNGQHQEHRLFVDHDTPHCRSNVVFKGALQGRDAHAVWIGDVLIRAAAEGTDTYELNRNLVLTDGARVDSVPNLEIETGEIVGAGHASATGRFDDEQLFYLMARGIPADEARRLVVRGFFTELVQQIGIPELEERLITKIEAELEASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBX9</accession>
    <name>A0A2G1XBX9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27140</name>
        <name evidence="3" type="ORF">CYQ11_18515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48757">
        <property type="protein sequence ID" value="PHQ48757"/>
        <property type="gene ID" value="BLA24_27140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14595">
        <property type="protein sequence ID" value="PPT14595"/>
        <property type="gene ID" value="CYQ11_18515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="17760" checksum="815FCC159499C42F" modified="2018-01-31" version="1">MTTDTVAQHHPRMHFHKLAPEVSKAMFALEKASREGLDPVLIELVKIRASQLNHCAFCLDMHVKDARKAGETEERIYLLSAWEEAEGFYTEKERAAIALTEAITVLTDGFVPDEVYERAARHFPEQELAQLIAMIVTINAWNRLGVTTRLVPGSYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBZ5</accession>
    <name>A0A2G1XBZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27295</name>
        <name evidence="3" type="ORF">CYQ11_18360</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48784">
        <property type="protein sequence ID" value="PHQ48784"/>
        <property type="gene ID" value="BLA24_27295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14567">
        <property type="protein sequence ID" value="PPT14567"/>
        <property type="gene ID" value="CYQ11_18360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="117" mass="12240" checksum="485016A952D4B440" modified="2018-01-31" version="1">MDVLIHAVVGLHIIGIAALLGGFMTQMKAMGKGEARMVPAMLHGALTMLVTGVALVGLNQAEDHTVNTFKIGVKLALLIMILGLVYVKRDEEKVDAASFGVVGAATAANVFIAVLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCD3</accession>
    <name>A0A2G1XCD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27850</name>
        <name evidence="3" type="ORF">CYQ11_17790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48878">
        <property type="protein sequence ID" value="PHQ48878"/>
        <property type="gene ID" value="BLA24_27850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14475">
        <property type="protein sequence ID" value="PPT14475"/>
        <property type="gene ID" value="CYQ11_17790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="288" mass="31517" checksum="64E6915AC6BD9CF5" modified="2018-01-31" version="1">MPTPPSSSVQAARKAVADRLREIRRDAGLTAKEVARRAGWYPSKASRLENAVTPPSDADIRAWCAACGADDVAVDLIAASRSAATMYVEWRRVQRTGLRRLQESFIPLFERTRVFRIYCSNVIPGVLQTHAYATALMSAITDFHGTPNDVAEAVEARLARSHVVREGNHRFALLVEESVLRHRVGDAETMAGQLGYLLSVTAYPSVSLGVIPFSASRRMWMIETFSVYDEDMAQVELLTAQVKLTAQVNVTAPTEIAQYLKAFGEFADLAVYGAKARALITSAVDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCF9</accession>
    <name>A0A2G1XCF9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2530 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27680</name>
        <name evidence="3" type="ORF">CYQ11_17960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48937">
        <property type="protein sequence ID" value="PHQ48937"/>
        <property type="gene ID" value="BLA24_27680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14507">
        <property type="protein sequence ID" value="PPT14507"/>
        <property type="gene ID" value="CYQ11_17960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="94" mass="10428" checksum="EEC19CF78E9C80D6" modified="2018-01-31" version="1">MTKWTPKHEAPEPLEGPVVATVTGGTILWFVLFVAQLPFYGWFSDHGHLWWLWTCLAGGGLGLIGVWYVRGRDAAIKRHAAARATESAHGEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCJ5</accession>
    <name>A0A2G1XCJ5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="9" type="ORF">BLA24_22885</name>
        <name evidence="10" type="ORF">CYQ11_23190</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48956">
        <property type="protein sequence ID" value="PHQ48956"/>
        <property type="gene ID" value="BLA24_22885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15399">
        <property type="protein sequence ID" value="PPT15399"/>
        <property type="gene ID" value="CYQ11_23190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="651"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="740" mass="79768" checksum="F82439A9AB25A2EA" modified="2018-01-31" version="1">MENETHYAEAVIDNGAFGTRTIRFETGRLAKQAAGSAVAYLDDDTMVLSATTASKKPKDQLDFFPLTVDVEERMYAAGKIPGSFFRREGRPSEDAVLTCRLIDRPLRPSFKKGLRNEIQIVETVMALNPDHLYDVVAINAASCSTQLAGLPFSGPIGATRVALIKGQWVAFPTHTELEDAVFDMVVAGRVLEDGDVAIMMVEAEATEKTIQLVKDGADAPTEEVVAAGLEAAKPFIKVLCRAQSELAAKAAKPEGEFPVFLDYQDDVLEALTAAVRTELAQALTIAGKQEREAELDRVKDVAAEKLLPQFEGREKEISAAYRSLTKTLVRERVIKEKKRIDGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLSPVTRKRYMHNYNFPPYSVGETGRVGSPKRREIGHGALAERAIVPVLPTREEFPYAIRQVSEALGSNGSTSMGSVCASTMSLLNAGVPLKAPVAGIAMGLISQEIDGKTHYVALTDILGAEDAFGDMDFKVAGTKEFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMMEAIDTPDEMSAYAPRIITVKIPVDKIGEVIGPKGKMINQIQEDTGAEITIEDDGTIYIGAADGPAAEAARATINGIANPTMPEVGERYLGTVVKTTTFGAFVSLMPGKDGLLHISQIRKLAGGKRVENVEDVLGVGAKVQVEIAEIDQRGKLSLIPVIEGEDGDADETKDESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCL6</accession>
    <name>A0A2G1XCL6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22910</name>
        <name evidence="3" type="ORF">CYQ11_23165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48960">
        <property type="protein sequence ID" value="PHQ48960"/>
        <property type="gene ID" value="BLA24_22910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15395">
        <property type="protein sequence ID" value="PPT15395"/>
        <property type="gene ID" value="CYQ11_23165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="595" mass="65211" checksum="866CB3E339AC56E0" modified="2018-01-31" version="1">MITLSQLRDLKRSEFEEAADGWGDVSSRAGAARTRVDNEITAKLHDTQKGEAANQAMAKLDTLSQNYHYIHTECGLIRTVLNGLAEELEAPQRKLKQALEDAKNLKFTVHDDGSVDYPRSPSTPAPLLQQPARDLRGTPPLLNPGGTDPNQAKAQAIADHIGQALREANEIDGRYARVLAKLGTGKDLDNTDWVDVAQDLKDVRAAAGKHFRESDIPRGKSPKENAAWWSGLSQEQRDEYVSLYPASIGALDGLPAIVRDDANRTVMRAEKAEITYQLAALRGHPPTKYQQKYNNITGLPLQGVQEITPQWKKWEEQIEDLEKKKAGIETINRRIAETGERGLPEAYLLGFDTKGRGHAIIATGNPDRAENTAVYVPGTGACLADIHTGLSRTEKLWRTSSAVDPRHSVSTIAWYGYDAPQDVKRDSPYSHYANDAAGATNQFFAGLRTSHDPGVEQHLTAVAHSYGTVVVGSAARQGHLPVDDVVFAGSPGAQVGRATDMDVPKGHVWNERAQGDDLVGTLGQFSHGHREWHWKTGVDFVVPSDARFGANQMATDTEGHGGYWDYDEKKDAASLSIKNQAKVIMGRYDEVAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM3</accession>
    <name>A0A2G1XCM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Type VII secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_22980</name>
        <name evidence="13" type="ORF">CYQ11_23095</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48972">
        <property type="protein sequence ID" value="PHQ48972"/>
        <property type="gene ID" value="BLA24_22980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15383">
        <property type="protein sequence ID" value="PPT15383"/>
        <property type="gene ID" value="CYQ11_23095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="488"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="569" mass="60315" checksum="D176DCEB02258C1B" modified="2018-01-31" version="1">MASRRDELNAYTFARKRTVAAFLQPSPTGTEEGAPRVLRTVLPGIVTGALLVAGFGAWGMFKPTAPKGWDDVAAHVIVGSDSTTRYVVLKTDGKKQLHPVLNLASAKLLLKEPKSSVIKVKESELDNGHIPRGPTLGIPYAPDRMPSAAEAGKKKQWAVCEQPGGNGKTTQKAVFLFAERDPKLKKLTGSQRLRGDQALYVQGPDDTRYLIDPQGVKYALGGADRKPAETPDAKPGADAKKDGKQDGKQGSAAAAAERKPADASDASEYNLLLRSIFKDGAQPQRVTKDWLATFKEGAPIVFPEIQGQIGGDAGVRTLPLKANRVGMVLEAPTGTGMQHYVVLRGKVQRVSEFVAKLLLNSKAEASLNQAGTPERVSASAFTPDADEFYGQYHWPSRVPRQANGTEAAGGGTANNTVCSVFGGLDSKGTPDLGTWAGTDYPATIPDGATSAYVTPGSGILYRQVTGRQTKNGSVFLVTDTGLRYAVQANNDSATDKSKIGDEKDQNKTGDDEAGQEQSPAPAAPQDVNKAQMRLGYQSVDPVPVPANWSGFLPTGPRLDPNSAAQPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCQ9</accession>
    <name>A0A2G1XCQ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ORF">BLA24_23290</name>
        <name evidence="9" type="ORF">CYQ11_22785</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49023">
        <property type="protein sequence ID" value="PHQ49023"/>
        <property type="gene ID" value="BLA24_23290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15331">
        <property type="protein sequence ID" value="PPT15331"/>
        <property type="gene ID" value="CYQ11_22785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="56"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="344" mass="37688" checksum="B66AC23CAE9AE4B6" modified="2018-01-31" version="1">MGSRGRTHAPTHARTREADGERAGAAPQTGGRAERRKAARRVKRRRRRSVVKEVPILMGVAVLITLVLKTFLLQAFVIPSGSMEQTIRIGDRVLVDKLTPWFGSRPERGDVVVFKDPGHWLEGEQSSSGSDPVGIKQGKQLLTFIGLLPSADERDLIKRVVGVGGDTVKCCDVDGRVTVNGTPLLEPYLHPGNPPSQLKFEVEVPRGRIFVMGDHRSNSADSRYHLDEPGHGTVAESQVVGRAVVIAWPFGHVRQLAEPDTYASVRDAPRASARTDVSPHNGTLTDRQGLLRLPTPAELSLVMGVVGLRRVCDRRERGVRSGRGGFGGRRTFRPRRAREAPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD21</accession>
    <name>A0A2G1XD21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24125</name>
        <name evidence="2" type="ORF">CYQ11_21950</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49157">
        <property type="protein sequence ID" value="PHQ49157"/>
        <property type="gene ID" value="BLA24_24125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15193">
        <property type="protein sequence ID" value="PPT15193"/>
        <property type="gene ID" value="CYQ11_21950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="10016" checksum="CE22519286A84F2D" modified="2018-01-31" version="1">MAILVHHRSAVWNQELYTATFNGAIPDTSKPPAGLIAHFAGPMASGGWQVIDVWESEDALRAFMETDVARVVQGIQAPPFESTVVDVANSLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD27</accession>
    <name>A0A2G1XD27_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enhanced serine sensitivity protein SseB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23885</name>
        <name evidence="3" type="ORF">CYQ11_22185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49120">
        <property type="protein sequence ID" value="PHQ49120"/>
        <property type="gene ID" value="BLA24_23885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15232">
        <property type="protein sequence ID" value="PPT15232"/>
        <property type="gene ID" value="CYQ11_22185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB_C" evidence="1">
        <location>
            <begin position="132"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="28265" checksum="210A0BAE309189E9" modified="2018-01-31" version="1">MSAGAESGLEQVLRQVAPGRYDSYEALLRALAEGRVWMLLWHGQAGSPDAQYGNMEVDGLGYAPCVTSAQELAASGWNRAHEVVSGRSVAASLYPDRWGLWLNPHAPGGGVGIPWLDLRRITAGLDRLPAGPLRLSEPAVDIPQFYALLGQNAHRTSVVRSLRRAWVQPTLGSPYLAVGLDLYDTSPAAVEAVRLMMQQSVGVVPEGLPVSTVSMADEYDPVAMWMRANARPFFDRDAYGGSAPAPTGGYGYPPQQGWQAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD86</accession>
    <name>A0A2G1XD86_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24325</name>
        <name evidence="3" type="ORF">CYQ11_21745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49196">
        <property type="protein sequence ID" value="PHQ49196"/>
        <property type="gene ID" value="BLA24_24325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15154">
        <property type="protein sequence ID" value="PPT15154"/>
        <property type="gene ID" value="CYQ11_21745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="881" mass="89874" checksum="BE2AE0286DF78B4F" modified="2018-01-31" version="1">MDPTNRGSEEFRDDESASATDGGRRRPPREGGLPAPETAGGPVRVVQLVAGDYLLTVNPVDGSEIEPCPPGAQPSRSRRHDPDERAELRRAATPPRPARPAGPEIPLLHRDEERERLARLISRGRSVRLTGPSGSGRSALLDAVAEDCEDLAPDGVVRLSGHHRTPTDVLYELFAAVHHAPLHRPDRAAMLAAVHDIGAVVVLDDLEFGGSTLDELLDATPECAFLLAATPDVAAPSADSHLEEVFLGGLDRTSCLELLERAVDRPLTDEEAGWAADLWFESEGLPLRFVQAGALLRQRDALAAAPAAVDEFGVFAERPYRAEDATEDPAEVQDVPLPTLAQAAAPAALLASRLGEAARDTLRFAVALGGELPHQAHLPALAGDTHADAVVGELLACGLISAVGSHYRLAAGVADQLLAQDYGDEAVARAHSAAQHYAWWAGHPSVTPERIAVEADAILAALAVLVADEDSGHRAAAVLLARTAAPAFAAALHWGAWERCLRHGQEAARAAGEVGEEAYFHHELGVLALCTGHVDRARAELEASIGLRGVLADKRGAVAGRRALALVADRSGLALGARRLPGQTPPRPLAGAGDKTPPLPPLPAPRADRSTSAGEEVPDARSEESAAPPAKAPASFAARQPAGNATTVVNRVPAASAVPPARPAPARVPAPPSGPPAGGPVARQPWVQKLMSGGNRRNLAAAGAGVLLAAVLGTVVTLGAASGGSTGGHSDTVKPGQSASQQDGGDGLTADEPAVGQPGAPQVPARKARPGETPRPGGSPGAPGGTTAPSPSASPSGGSATRSPSPDRPSPSPSRTSGGESPKPSPKPTPTKTGGDKPSDSPKPPTTAPSQPPTSGSSNSASGPAPGRTTTGAPAPGTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDE0</accession>
    <name>A0A2G1XDE0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24665</name>
        <name evidence="2" type="ORF">CYQ11_21405</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49257">
        <property type="protein sequence ID" value="PHQ49257"/>
        <property type="gene ID" value="BLA24_24665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15091">
        <property type="protein sequence ID" value="PPT15091"/>
        <property type="gene ID" value="CYQ11_21405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="279" mass="29150" checksum="A09EF98F6CFA4FF6" modified="2018-01-31" version="1">MSATDHSRAAAGALLLCRADPDRVRPSAQLLREPLLVAPAGGGWSVLVPAEEPGPGAAENPAALTAEWTHALTVAESWPAVGLWWDEEGAGFVVAAGFRRTLGYTWLADGSPLGDEGALTALRARLGLDPVLDAAAFDRLTAPDSDADAAARVRGLVAVLARAGLHLPQGLVPGASARTLRAAMEAAPSAEAVEWPGWRAAMRDGLDATERGPLGTWVRGPRARALGTAELLAGAVLLSRARRAERPRRGWALAGAVLLADGALTIAYDAWRRRGPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDJ3</accession>
    <name>A0A2G1XDJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">YciI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24915</name>
        <name evidence="5" type="ORF">CYQ11_21155</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49302">
        <property type="protein sequence ID" value="PHQ49302"/>
        <property type="gene ID" value="BLA24_24915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15047">
        <property type="protein sequence ID" value="PPT15047"/>
        <property type="gene ID" value="CYQ11_21155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="141" mass="15600" checksum="B4501F31250AF78A" modified="2018-01-31" version="1">MPRFMMIVKASEESEAGMMPTKQMIADMSRYNEELAGAGAMLAGDGLHPTSKGARVSYSGGTPVVTEGPFGNTRDLVAGYWIIQVGSMDEALEWARRIPFEEGEVEVRQVFEPSDFPADVLSPEDAAREESLREELRRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE74</accession>
    <name>A0A2G1XE74_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">BLA24_26120</name>
        <name evidence="5" type="ORF">CYQ11_19520</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49512">
        <property type="protein sequence ID" value="PHQ49512"/>
        <property type="gene ID" value="BLA24_26120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14768">
        <property type="protein sequence ID" value="PPT14768"/>
        <property type="gene ID" value="CYQ11_19520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="9052" checksum="54BE623E87232CE6" modified="2018-01-31" version="1">MATTTDATTDATDALGYEQARDELIDVVRRLEAGGTTLEESLALWERGEALAKVCRRWLDGARARLDAALAQEEGEETEPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF94</accession>
    <name>A0A2G1XF94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19970</name>
        <name evidence="4" type="ORF">CYQ11_10820</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49910">
        <property type="protein sequence ID" value="PHQ49910"/>
        <property type="gene ID" value="BLA24_19970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13315">
        <property type="protein sequence ID" value="PPT13315"/>
        <property type="gene ID" value="CYQ11_10820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="185"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="328"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="589" mass="63376" checksum="09BE53FB8C214E55" modified="2018-01-31" version="1">MSGTLDGKGGTPGSEPPVVTPVVTQRHVTSQEFRAAFRAAELGMAVVDRDGLVRTANDALGALLGTDPARLQDSPAAEFTGLTEDSRTWSAYRDVLLGRRDRLHCTRRLRPAAGQGVWAEVTVTPLPETRDALLSVADISDRRDLRARLRHLRMHDPVTRLPNRSLFFERLAAALAATAVAGGSGRIGLCYLDLDGFKAVNDTLGHGAGDRLLGAVARRLTECAAPGGHLVARLGGDEFALLVEESRGTEQLIDLAASVQSALSRPFEVSGQRLAVSASIGVVERPAAGTHATELMQAADTTLYWAKADGKARWTLFDPERNAHRVTRQTLSSTLRPAVEREEFDLQYQPLVGLGDGVVRGVEALVRWHHPQFGTLAPNRFIGLAEETGAIVPLGRWVLATACRQARRWQLDHPCEPLVVSVNVAVRQVWDSDLVADVAGILAETGLPPSLLQLELTESAVMGSGGRPLQQLQALSDMGVAIAIDDFGTGYSNLAYLSRLPVSTLKLDGSFVHGFRTQEHPNPADETIVEALVQLAHRLGLTVTAECVESAEQAERLGRIGCDTGQGWFYSRPVPAERISALLSTGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB4</accession>
    <name>A0A2G1XFB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20130</name>
        <name evidence="3" type="ORF">CYQ11_10660</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49936">
        <property type="protein sequence ID" value="PHQ49936"/>
        <property type="gene ID" value="BLA24_20130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13288">
        <property type="protein sequence ID" value="PPT13288"/>
        <property type="gene ID" value="CYQ11_10660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="8376" checksum="A4383E2CC46889D8" modified="2018-01-31" version="1">MTREGAPMAMALRGLLMAGGVAVMVLGVVLLFFWHAEVVELTGAPRLVSALGLRAAEAAVLYGGSWLVVRGWNGGPRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFG8</accession>
    <name>A0A2G1XFG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">WhiB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_20400</name>
        <name evidence="15" type="ORF">CYQ11_10385</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49978">
        <property type="protein sequence ID" value="PHQ49978"/>
        <property type="gene ID" value="BLA24_20400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13245">
        <property type="protein sequence ID" value="PPT13245"/>
        <property type="gene ID" value="CYQ11_10385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ49978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="18490" checksum="E8168346CBB6DAC0" modified="2018-01-31" version="1">MATSLIGGTRTAHLVARPSGATLAFELAPDPGLAGALCVAVEPELFFPEKGDHKTANLAREICARCPVIEACLADALKMEGGRSHSSRFGIRGGLTPNQRYQLSRRMRQSASASEAASRPVEVSTVPERKPAPCGTRRGYLRHRREGENACEACLNHAAGGRRRLTAGTAEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ0</accession>
    <name>A0A2G1XFQ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_20690</name>
        <name evidence="10" type="ORF">CYQ11_10090</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50031">
        <property type="protein sequence ID" value="PHQ50031"/>
        <property type="gene ID" value="BLA24_20690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13191">
        <property type="protein sequence ID" value="PPT13191"/>
        <property type="gene ID" value="CYQ11_10090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="28"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="50116" checksum="0BD82F20FA039018" modified="2018-01-31" version="1">MTPKATGDPGQAPASGGDGLKAGLKNRHLSMIAIGGVIGAGLFVGSASGIAAAGPGILISYALVGAMVVFVMRMLGEMAAANPTSGSFSAYADRALGRWAGFTIGWLYWFFWVVVLAVEATAGAKILEGWMPAVPQWGWALIVMIVLTITNLASVSSYGEFEFWFAGIKVVAISAFVIIGLLAVFGVLPGSDNPGHGFDLLTSHGGFLPNGPGAILTGVLMVVFSFMGSEIVTLAAGESEDPQRAVSQATNSVIWRIGVFYLGSILVVVSLLPWDSKEIADKGSYVAALDSIGIPHAGQIMNVIVLTAVLSCLNSGLYTASRMAFSLGQRGDAPKAFAVTNKSGVPAAAIIGSVVFGFISVFFNYMWPDTVFKFLLNASGAIALFVWLAICFTQLKMRGIILREAPEKLRVRMWLFPYLTWATIGMILFVLGYMVVDGGDNREQVLLSTLVGVVVLGIGVVLDRRRRGAAASVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ4</accession>
    <name>A0A2G1XFQ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="11" type="synonym">cgtA</name>
        <name evidence="6 11" type="synonym">obg</name>
        <name evidence="11" type="synonym">yhbZ</name>
        <name evidence="11" type="ORF">BLA24_20950</name>
        <name evidence="12" type="ORF">CYQ11_09830</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50070">
        <property type="protein sequence ID" value="PHQ50070"/>
        <property type="gene ID" value="BLA24_20950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13149">
        <property type="protein sequence ID" value="PPT13149"/>
        <property type="gene ID" value="CYQ11_09830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="160"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="348"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="480" mass="50929" checksum="E8E58746A6FA0C1B" modified="2018-01-31" version="1">MTTFVDRVELHVAAGNGGHGCASVHREKFKPLGGPDGGNGGRGGDVILVVDQSVTTLLDYHHSPHRKATNGKPGEGGNRSGKDGTDLVLPVPDGTVVQDGQGNVLADLVGHGTTFVAAQGGRGGLGNAALASARRKAPGFALLGEPGQTQDIVLELKTVADVALVGYPSAGKSSLISVLSAAKPKIADYPFTTLVPNLGVVTAGATVYTIADVPGLIPGASQGKGLGLEFLRHVERCEVLVHVLDTATLESERDPLTDLDVIEAELAEYGGLENRPRIVVLNKVDIPDGKDLAEMIRPELEGRGYRIFEVSAVSREGLKELSFALAGIVAEARAAKPKQEATRIVIRPKAVDDAGFTVVQEEDGLFRVRGEKPERWVRQTDFNNDEAVGYLADRLNRLGVEDQLMKAGARAGDGVAIGPEENAVVFDWEPSMAAGAEMLGRRGEDHRLEAPRPAAQRRRDRDAERDEASQEYEGFNPFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFW1</accession>
    <name>A0A2G1XFW1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">BLA24_21295</name>
        <name evidence="13" type="ORF">CYQ11_09490</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50123">
        <property type="protein sequence ID" value="PHQ50123"/>
        <property type="gene ID" value="BLA24_21295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13096">
        <property type="protein sequence ID" value="PPT13096"/>
        <property type="gene ID" value="CYQ11_09490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="47"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="68"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="34256" checksum="F1E82265F05140C7" modified="2018-01-31" version="1">MDNASAPSQAPHRAGFACFVGRPNAGKSTLTNALVGTKVAITSNRPQTTRHTVRGIVHRPEAQLVLVDTPGLHKPRTLLGERLNDVVRTTWAEVDVIGFCLPADQKLGPGDKFIAKELAGIKKTPKIAIVTKTDLVDSKQLAEQLIAIQQLGEELGIQWAQIVPVSAVGDKQVSLLADLIAPLLPESPPLYPEGDLTDEPEQVMVAELIREAALEGVRDELPHSIAVVVEEMLPREDRPKDKPLLDIHANVYIERPSQKGIIIGPKGARLKEVGMKSRKHIEALLGTPVYLDLHVKVAKDWQRDPKQLRKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG85</accession>
    <name>A0A2G1XG85_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22015</name>
        <name evidence="3" type="ORF">CYQ11_08770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50242">
        <property type="protein sequence ID" value="PHQ50242"/>
        <property type="gene ID" value="BLA24_22015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12973">
        <property type="protein sequence ID" value="PPT12973"/>
        <property type="gene ID" value="CYQ11_08770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="336" mass="36701" checksum="A7B4D79B5BD1DADC" modified="2018-01-31" version="1">MRLGLALGYWGRHPDPRQLALAQQAERLGYHSVWTSESWGSDAFTPLTWIAAHTRRIRLGTAVAQMAARTPTATAMHALTLDHLSGGRVLLGLGLSGPQVVEGWYGRPFPDSPLTATREYVDVVRQVLRRQAPVELAGRYHCHPYTGPGATGLGKPLRSVTHPLRAGLPVLLGAEGPRNVAQTTRVADGWLPLYWSPARSDLYAESLAGTPAGFMVAPLTQARICADVTEGLRPVKTMLALYIGGMGHAARNFHADLMARMGYGEEARRVQRLFLSGRREEAVEAVPDSFADEISLVGPRERVAERLELWRAGPVTDLLVITPDEETLRVLAELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGI7</accession>
    <name>A0A2G1XGI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22660</name>
        <name evidence="2" type="ORF">CYQ11_08130</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50346">
        <property type="protein sequence ID" value="PHQ50346"/>
        <property type="gene ID" value="BLA24_22660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12866">
        <property type="protein sequence ID" value="PPT12866"/>
        <property type="gene ID" value="CYQ11_08130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="92" mass="9987" checksum="6843A2C86FCBF751" modified="2018-01-31" version="1">MIVRIMGEGQVKLADSHFTELNKLDDELLDEMESGDEEGFRRTLGALLEAVRRLGTPLPDDALEPSELILPAPDASLAEVRAMLSDDGLIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGK8</accession>
    <name>A0A2G1XGK8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage shock protein A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_22655</name>
        <name evidence="5" type="ORF">CYQ11_08135</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50345">
        <property type="protein sequence ID" value="PHQ50345"/>
        <property type="gene ID" value="BLA24_22655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12867">
        <property type="protein sequence ID" value="PPT12867"/>
        <property type="gene ID" value="CYQ11_08135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="28333" checksum="3C16C6657773537C" modified="2018-01-31" version="1">MKRMGMIFRAKANKALDRAEDPRETLDYSYQKQLELLQKVRRGVADVATSRKRLELQLNQLQSQSSKLEDQGRKALALGREDLAREALTRRAALQQQVSDLETQHQTLQGEEEKLTLASQRLQAKVDAFRTKKETIKATYTAAQAQTRIGEAFSGISEEMGDVGMAIQRAEDKTAQLQARAGAIDELLASGALDDPTGMAKDDLTAELERISGGSDVELELQRMKAELSGGGQKPAIEGGAAGQAGEQQHNQHRFDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGR2</accession>
    <name>A0A2G1XGR2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22060</name>
        <name evidence="3" type="ORF">CYQ11_08725</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50423">
        <property type="protein sequence ID" value="PHQ50423"/>
        <property type="gene ID" value="BLA24_22060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16433">
        <property type="protein sequence ID" value="PPT16433"/>
        <property type="gene ID" value="CYQ11_08725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="375" mass="39502" checksum="F4F4DE5084A72D64" modified="2018-01-31" version="1">MDMRRTAFTVTVDGSYAAWLALGRGTDGWFPERWTLDGPEPYAVSLPGSQPEEPDSEVLPLSDGRVLIRRRVAERYALSLLYPTGPGTGELPLGTIECPYLSLLPPAPDGSSAYALVHGERSTTLWRVHGGAGGPELLATVQGRCEGGAWLDRSGRLLALDRELEGLTKTVVVDLGRGGETSPLLQITDKSNDRLLLAEPDSGLLLVRSDAPGVDRLGWGVLGSSRPVRFPECLLLPDASLTPFAAQPGQGLSPEECSVAFRVDRGAADSWVGVWRPATKRLRQFPGPTGWLPGAGLWTACGELRLPFVTAGVPCGLARLRMPGEAGAPEPGGETERAVPVVEGTAGTATAGAEPDGSAPARPVPLQQAPCARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGU0</accession>
    <name>A0A2G1XGU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16490</name>
        <name evidence="3" type="ORF">CYQ11_16795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50446">
        <property type="protein sequence ID" value="PHQ50446"/>
        <property type="gene ID" value="BLA24_16490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14302">
        <property type="protein sequence ID" value="PPT14302"/>
        <property type="gene ID" value="CYQ11_16795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="280"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="40765" checksum="768DDB977A4E9071" modified="2018-01-31" version="1">MSVTIDIAGLPPERLVFRPSPLLELCTALHALAEPGHHPGLHGWTTATSSALKPELADRLCEADFLWTSTFSDIALPFAALPDTQGQPGATLAEDLDMLDRLSDELFVDAAMEISCTSRYGSGAPSPLVDAEAREQALERATARGPRPLSFAKRLLDDPPAVRAWMRRLFEDCAEAFFHDIWQRVRVQLAADARHKTEVLRHKGLAEALAEVSSAVTLADDGSRIHVDKLGSGRTTALDPAVGPGVTFVPSSFGWPHLWVLHARSWRPVVHYPVAAPELPGPRSLDLLTLRLEALSHPMRIRMCRYLARASYTTGELAAAHDISAPEVSRHIAVMKKAGLVTTRRRGRYVMHQLDVTVVARLGSDFLEGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGV1</accession>
    <name>A0A2G1XGV1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme F420 biosynthesis-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16595</name>
        <name evidence="2" type="ORF">CYQ11_16690</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50463">
        <property type="protein sequence ID" value="PHQ50463"/>
        <property type="gene ID" value="BLA24_16595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14282">
        <property type="protein sequence ID" value="PPT14282"/>
        <property type="gene ID" value="CYQ11_16690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="378" mass="40907" checksum="A73D456EE76F68DF" modified="2018-01-31" version="1">MTSVGGTEMVDWKLAVATATRLVRPGPEVSRGEAREVVAELRRHARSSEEHVRGFTGMAPPEAAAGNGDTPVLVVDRAGWIKANVAGFRALLGPLLEKMQDRRSNMPGGAVFGTVGGKVTGVELGMLLSFLASRVLGQYETFAPVTGDLPGAPAGGGRLLLVAPNIVHVERELEVAPHDFRLWVCLHEETHRTQFTAVPWLRDHIQGEIHTFLAETDVDPATLLERIRQAAQSFAGGNPPQEEGGGGRSIVDLVQTPAQREILARLTAVMSLLEGHADYVMDGVGPQVVPTVAEIREKFQKRRASGAGRLDAALRKLLGLDAKLRQYRDGERFVRAVVDEVGMDGFNRVWTSPNTLPTKAEIAKPADWVARVHGRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGZ4</accession>
    <name>A0A2G1XGZ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16870</name>
        <name evidence="2" type="ORF">CYQ11_16415</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50503">
        <property type="protein sequence ID" value="PHQ50503"/>
        <property type="gene ID" value="BLA24_16870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14241">
        <property type="protein sequence ID" value="PPT14241"/>
        <property type="gene ID" value="CYQ11_16415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="69" mass="7859" checksum="BF86BEBEA19CCDA1" modified="2018-01-31" version="1">MGWTHDYRDVTDVTHERGAEGDAALVVTEVSERGEYRPGAGSDPRVGIPRIIHRRARWVSARLRHPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH85</accession>
    <name>A0A2G1XH85_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_17535</name>
        <name evidence="13" type="ORF">CYQ11_15740</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50604">
        <property type="protein sequence ID" value="PHQ50604"/>
        <property type="gene ID" value="BLA24_17535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14141">
        <property type="protein sequence ID" value="PPT14141"/>
        <property type="gene ID" value="CYQ11_15740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008620">
        <property type="entry name" value="FixH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05751">
        <property type="entry name" value="FixH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="10">
        <location>
            <begin position="52"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="11">
        <location>
            <begin position="366"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="654" mass="67191" checksum="47D94E4A2691C88B" modified="2018-01-31" version="1">MTPTTGRRTAPRATAGRAAVRGTARRVPTLLGALLAALLCTLTLGAGTASAHAALTATDPADGSVLPSAPGRVTLTFSEGVLLSPDSVRVLDPRGGRVDEGRPAHVDGRSDSAAVALRTGLADGTYTVAWQAVSADSHPVAGAFTFSVGAPSKTTVTVKSAATEIDPAVETFYDIGRYAAYAGFVLLVGGCVFAGVCRSSRPVQRVAVGGWVGLFVSTTLLLLLRGAYTSGKGLGSVADLSLLGDVLSTKPGAALLSRLLLLSAAAVFLAVLFGTYAREDAAPRGRADGPDAPRRGVAYGLGAGGAVVAGGLAATWAMAEHASAGLQPWLAMPADVAHLLAVAVWLGGLAALLATLWSGVPVRRSAVERFSRLAFASVCVLVVTGVYQSWRQVGSWGALTGTEYGRLLLIKAVLVAALVALAFFSRRWTGRLTDASATRRQPGRQPRKATAAAGGTGAGKAADPVRAAQLARQQAALDRAAGRRERDADGVRTGLRRSVLAETAVAVVVLAVTTLLTSTQPGRAETEQRQAAGKSAAPSAGGPAEVRIAYDTGGANGRGTARVVIDPARSGGNTVTVTLTDASGRPVDVPELTLSLTERENEIGPLRAALRRQSPGQWQATGFRLPMAGDWQLSLTVRTSDIDQVTEIENVKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHC9</accession>
    <name>A0A2G1XHC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17725</name>
        <name evidence="3" type="ORF">CYQ11_15550</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50636">
        <property type="protein sequence ID" value="PHQ50636"/>
        <property type="gene ID" value="BLA24_17725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14109">
        <property type="protein sequence ID" value="PPT14109"/>
        <property type="gene ID" value="CYQ11_15550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020246">
        <property type="entry name" value="Uncharacterised_SCO3924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17260">
        <property type="entry name" value="DUF5326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="72" mass="7780" checksum="A8B2BE1E50C9B51F" modified="2018-01-31" version="1">MAEKGIFAGLPWWVQWVAVPVVVLVVFGSLIMSVLGFVIGLLFKALLLVVLVGGLIFVVKKFTSSSSSRGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHE9</accession>
    <name>A0A2G1XHE9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan bridge formation glycyltransferase FemA/FemB family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Peptidoglycan bridge formation protein FemAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17840</name>
        <name evidence="3" type="ORF">CYQ11_15435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50656">
        <property type="protein sequence ID" value="PHQ50656"/>
        <property type="gene ID" value="BLA24_17840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14089">
        <property type="protein sequence ID" value="PPT14089"/>
        <property type="gene ID" value="CYQ11_15435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="42551" checksum="4FF787092C37B64B" modified="2018-01-31" version="1">MSLTLRTISREQHLAYIQSLPAASHMQVPGWADVKAEWRSENLGWFDKTGQMVGAGLVLYRQLPKIKRYLAYLPEGPVINWFSPNLTDWLQPMLAHLKQQGAFSVKMGPPVVIRRWDANAIKTGIADPDVKRLRDVEATFIEPRAFEVADQLRRMGWQQGEDGGAGFGDVQPRYVFQVPLENRSLEDVHKGFNQLWRRNIKKAEKAGVEVVQGGYEDLATWQHLYEITAERDKFRPRPLSYFQRMWTALNSEDPNRMRLYFAVHEGEAVAAATMLIVGGHVWYSYGASANHKREVRPSNAMQWRMLRDAYALGASVYDLRGIGDSLDENDHLFGLIQFKVGTGGQAAEYLGEWDFPLNKLLHKALDIYMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHU4</accession>
    <name>A0A2G1XHU4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_18085</name>
        <name evidence="12" type="ORF">CYQ11_15190</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50699">
        <property type="protein sequence ID" value="PHQ50699"/>
        <property type="gene ID" value="BLA24_18085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14047">
        <property type="protein sequence ID" value="PPT14047"/>
        <property type="gene ID" value="CYQ11_15190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="377"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="445"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="512"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="579"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="672" mass="70316" checksum="55E7DC5C1529E82D" modified="2018-01-31" version="1">MEEPRRLGGRYELGSVLGRGGMAEVYLAHDTRLGRTVAVKTLRVDLARDPSFQARFRREAQSAASLNHPSIVAVYDTGEDYVDGVSIPYIVMEYVDGSTLRELLHSGRKLLPERSLEMTIGVLQALEYSHRAGIVHRDIKPANVMLTRTGQVKVMDFGIARAMGDAGMTMTQTAAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLTVRPPFIGDSPVAVAYQHVREEPNPPSIHDPEITPEMDAIVLKALTKDPDYRYQSADEMRADIEAALDGQPVAATATLGAVGYGAEDQPTTMLRPQDHHPGGAGQTSMMPPVADGGGYGGYDGGAGGGRRGGGRKSNLSTILLVVAGVLVLVGAIFIGKSLFGGGGNGSQVKVPSLKGQSLADAQQLGENGHFKVVQSGTKPCDDVPKNKVCTQDPGAGGKVDRGGDVKVTLSEGAPKVQVPDVTVMKFDEAVKLLEKRGFTYKQKQKETQDSTPGVVLSQDPEGGSQAEKGTEIVLTVAAAPASKTVPPVVGQPFDAAQKQLKDLGFDVKREDEDSTQPAGTVSRQSPDGNTSARAGSTVTLYVSKGAPQNIPVPAVINMKLKDAKKAVTGAGLKVGAITGPGDDNAMVMVTDPVAGTQVPKDTPVNITTVGGVPGGDTGTGTNAGQDGGFFGGLIGGRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI24</accession>
    <name>A0A2G1XI24_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50902">
        <property type="protein sequence ID" value="PHQ50902"/>
        <property type="gene ID" value="BLA24_18370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="245" mass="24418" checksum="19F4B4B182EEE6E5" modified="2018-01-31" version="1">MPVHALGARAVRRGRPAPAGRRAHRLPGGLSTVHNRTLRTAAAALTAAAALTLTACGGDGGSDGKAKDKADTATAQEQADTAGDSTDATDTTDGGADDKPQDTGDACLPGTVKVEAKAVKSPVNHVLLTATNTGKSPCTAYGFPFLRFDQDQATAGVVEESKPKAGGVKLAPGKAAHAAVIASAADGSAGAGREAGQLSVTLQTPGGDPLPGKAAQPALPGGALHVDDSARTTYWQDTEAAALKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIB9</accession>
    <name>A0A2G1XIB9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14525</name>
        <name evidence="3" type="ORF">CYQ11_13550</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51002">
        <property type="protein sequence ID" value="PHQ51002"/>
        <property type="gene ID" value="BLA24_14525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13776">
        <property type="protein sequence ID" value="PPT13776"/>
        <property type="gene ID" value="CYQ11_13550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304805" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="7598" checksum="F613CB5B005C31FA" modified="2018-01-31" version="1">MPLAQHTHHIVGTAAAALIVAASGALGGGVAAAAGPGDTDVRECLDKGGAVTLEREGGRLTPVVKKVCTGGSLDGQPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM4</accession>
    <name>A0A2G1XIM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoacid:acceptor oxidoreductase subunit alpha</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">2-oxoglutarate ferredoxin oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_14445</name>
        <name evidence="6" type="ORF">CYQ11_13630</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50989">
        <property type="protein sequence ID" value="PHQ50989"/>
        <property type="gene ID" value="BLA24_14445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13789">
        <property type="protein sequence ID" value="PPT13789"/>
        <property type="gene ID" value="CYQ11_13630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="54"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="297"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="654" mass="69675" checksum="B36F2BF36E082535" modified="2018-01-31" version="1">MTSQVSSPAEQADPAAQRGETELHDSLAGRPSPAGGTKEVRRLDRVIIRFAGDSGDGMQLTGDRFTSETASFGNDLSTLPNFPAEIRAPAGTLPGVSSFQLHFADHDILTPGDAPNVLVAMNPAALKANIGDVPPGAEIIVNTDEFAKRPMAKVGYATSPLEDGSLDAYNVHPVPLTTLTIEALKEFGLSRKEAERSKNMFALGLLSWMYHRPTDSTEAFLRKKFAKKPQIAEANVAAFRAGWNFGETTEDFAVSYEVAPATSAFPPGTYRNISGNLALSYGLVAAARQADLPLYLGSYPITPASDILHELSKHKNFGVRTFQAEDEIAGIGAALGAAFGGALAVTTTSGPGVALKSETIGLAVSLELPLLVVDIQRGGPSTGLPTKTEQADLLQAMYGRNGEAPVPIVAPRTPADCFDAALDAARIALTYRTPVFLLSDGYLANGSEPWRVPDPDELPDLRVRFATGPNHTLADGTEVFWPYLRDPHTLARPWAVPGTPGLEHRIGGIEKQDGTGNISYDPANHDFMVRTRQAKVDGVAVPDVVVDDPGGLARTLVLGWGSTYGPITAAVRRVRAGGGTLAQAHLRHLNPFPANLGEVLGRYETVIVPEMNLGQLATLLRAKYLTDVRSHTQVSGMPFKAEQLADVFKEATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIN9</accession>
    <name>A0A2G1XIN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15180</name>
        <name evidence="3" type="ORF">CYQ11_12890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51114">
        <property type="protein sequence ID" value="PHQ51114"/>
        <property type="gene ID" value="BLA24_15180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13663">
        <property type="protein sequence ID" value="PPT13663"/>
        <property type="gene ID" value="CYQ11_12890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="246"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="40928" checksum="198C63F738C05F48" modified="2018-01-31" version="1">MTPGKRKVAVVGVALADCGRLDTVTPYALHAQAARRALADSGLDRSVIDGFASTGLGTLAPVEVADYLGLRPSWVDSTSVGGATWEVMASHATDAIAAGHANAVLLVYGSTARADIKAGRRTSHLSFGTSGPAQFEAPYGHTLIAKYAMAARRHMHQYGTTVEQLADIAVQARTNAAHNPHALYRTPLSVDDVLSGPLIADPFTTLHCCVRSDGGCAVLLAAEEYTTDAARPPVWVLGTGTAVSHSAMSEWEDFTVTPAAVSGRLAFERAGVTPRDIDVAQLYDAFTYMTLVTLEDLGFCAKGEGGTFASGGRLTTGGALPVNTDGGGLSACHPGMRGLFLLVEAVRQLRGEAEEGRQVHRPDGRLPQLAVASGTGGWFCSSGTVVLGRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIP8</accession>
    <name>A0A2G1XIP8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_14880</name>
        <name evidence="6" type="ORF">CYQ11_13190</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51061">
        <property type="protein sequence ID" value="PHQ51061"/>
        <property type="gene ID" value="BLA24_14880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13716">
        <property type="protein sequence ID" value="PPT13716"/>
        <property type="gene ID" value="CYQ11_13190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="317"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="539" mass="59575" checksum="2BC2F7C29EEBD6D5" modified="2018-01-31" version="1">MGHVEAAHLEYDLPDGRPLLGDVSFRVGEGASVALVGANGAGKTTLMRLISGELQPHGGSVTVSGGLGVMPQFVGSVRDERTVRDLLVSVAQPRVRAAAKAVDAAENAIMTVDDEAAQMAYAQALADWAEARGYEAETTWDMCTMAALGVPYEKAQWRQVRTLSGGEQKRLVLESLLRGTDEVLLLDEPDNYLDVPGKRWLEERLRETKKTVLFVSHDRELLARAAEKIISVEPGPAGSDVWVHGGGFGTYHEARKERFARFEELRRRWDEKHAQLKKLVITLRQAAAVSHEMASRYAAAQTRLRKFEEAGPPPEPPREQDIRMRLRGGRTGVRAVTCAQLELTGLMNPFDLEVFYGERVAVLGSNGSGKSHFLRLLAGEDVAHTGGWKLGARVVPGHFAQTHAHPELMGRTLVDILWTEHAKDRGGAMSALRRYELERQGDQPFEKLSGGQQARFQILLLELAGTTALLLDEPTDNLDLESAEALQEGLEAYEGTVLAVTHDRWFARSFDRFLVFGADGRVREVPEPVWDEGRVARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIY3</accession>
    <name>A0A2G1XIY3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transglut_core3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15625</name>
        <name evidence="3" type="ORF">CYQ11_12450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51185">
        <property type="protein sequence ID" value="PHQ51185"/>
        <property type="gene ID" value="BLA24_15625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13592">
        <property type="protein sequence ID" value="PPT13592"/>
        <property type="gene ID" value="CYQ11_12450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14636" checksum="BF1CED0889FE2F80" modified="2018-01-31" version="1">MTASRRRLPLSRRPLPLLAVAAGHLIGRLPPRRIRSVLTVAARGARPASYAEAGRARGTVTAVSVRCAGEGCLPRSIATALLCRVHGSWPTWHAGVRTLPFRAHAWVEAEGRPVDEPLSTAQMRPVVTVSAGRAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ31</accession>
    <name>A0A2G1XJ31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15760</name>
        <name evidence="3" type="ORF">CYQ11_12315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51210">
        <property type="protein sequence ID" value="PHQ51210"/>
        <property type="gene ID" value="BLA24_15760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13566">
        <property type="protein sequence ID" value="PPT13566"/>
        <property type="gene ID" value="CYQ11_12315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="391" mass="40707" checksum="E4AA4D90973FC7B2" modified="2018-01-31" version="1">MVDVQGAVADGFEPVRDAFADNFARRGERGAAVAVYRDGRKVVDLWGGAKDADGGSEPWQRGTAQVVRSATKGVAAAVLLLLHQRGQVDLDAPVGTYWPEFKAAGKERVLVRHLLAHRAGLPALDVPLTPAEAADGVSGPRALAGQAPAWEPGTDHGYHAQTYSWLLGELVLRVTGRSIGTWVAEEIAGPLGADLWIGLPDAERERVGRIADAPAPAAPASAGLRVRPKASVSDAYRDPASLTRRAFAAIDPPADENDAAYRAAELPASAGIATADALARFYASLIGVVDGGRRLFAPATLTLARTEESAGPDRVLVVNTRFGLGYMLHGPASPLLAPGSFGHPGRGGSLAFADPESGVSFGYVTNGMQKNVTADPRAQALVRAVARSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ45</accession>
    <name>A0A2G1XJ45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall assembly protein Knr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15945</name>
        <name evidence="3" type="ORF">CYQ11_12130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51243">
        <property type="protein sequence ID" value="PHQ51243"/>
        <property type="gene ID" value="BLA24_15945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13532">
        <property type="protein sequence ID" value="PPT13532"/>
        <property type="gene ID" value="CYQ11_12130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032869">
        <property type="entry name" value="WHH_dom_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14414">
        <property type="entry name" value="WHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="160"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="35239" checksum="CB2EFE03D3926319" modified="2018-01-31" version="1">MTTGRLGQQAAPPNAAYAGQVVHFPDPVRRSRYPKGVRIDDEGFPDFSPYARAAAEIAEPPEGFGVDELRLTDYVSANAAQHAAGHELWASLPVVATPHGWTWHHVARTRRLELVPAEVKALLRHHAGLATAAVAQDKRGTRPLQETRPVHFALPQRDLAVTEEQVQGVEEDLGYRLPGAYRAFLKAAGGCAPVGAALDAELGLLVDQPLFTVRDEAAVNDLVYVNKCLRDHFTKDYLGVGFVQGGVLAVKVKGEAVGSVWFCPYDDARDRDGWTVQDRVERLLLPCGEDFDAFLSRLAGGPPELETVANLMVDGGFAHVVPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ52</accession>
    <name>A0A2G1XJ52_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_16195</name>
        <name evidence="5" type="ORF">CYQ11_11880</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51284">
        <property type="protein sequence ID" value="PHQ51284"/>
        <property type="gene ID" value="BLA24_16195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13491">
        <property type="protein sequence ID" value="PPT13491"/>
        <property type="gene ID" value="CYQ11_11880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="511" mass="54117" checksum="C066279A90F29E12" modified="2018-01-31" version="1">MASSLTKDAAEREKTSPAVGGKTFFGHPRGLAPLFMTEMWERFSYYGMRALLVIYLIAGGPDAKPGSQGGGLGMSEANAVAIYSVYVAMVYLLAMPGGWFGDRVWGPRKTVAIAGGVIMAGHLCLALPGQAAFFAGLALVAIGSGLLKSNISTMVGHLYDGPKDPRRDGGFTIFYMGVNTGAFAAPLVIGTVGQEVNWHLGFALAAMGMGIGLACFLFGSRHLSPVSSTVPSPLPKDERNVLLRKAAIWLGVAAVFYGVVGGTGHFTLNWAVIPITILGLIIPITVLFRIKRDKELSDTEQTKVSGYIWFFVAAAVFWMIFDQAGSTMSTFAEKKTTDNVFGLHFPSSWFQSVNPLWVMALAPVFASVWLALARRRKEPTTTVKFSLAMIAIGVSFVVFASAMGLASDGAKVSPAWLLGIYMVQTMGELCLSPVGLSLTTKMAPQKYASQMLGVWFLAVTAGDCVTGLLSTAGVDLNGVGVILGEAAIAVAAGTAIWVSRKKVEGLMGDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ83</accession>
    <name>A0A2G1XJ83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_16185</name>
        <name evidence="5" type="ORF">CYQ11_11890</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51283">
        <property type="protein sequence ID" value="PHQ51283"/>
        <property type="gene ID" value="BLA24_16185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13492">
        <property type="protein sequence ID" value="PPT13492"/>
        <property type="gene ID" value="CYQ11_11890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305582" evidence="3">
        <location>
            <begin position="35"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="293" mass="29786" checksum="AAE9813BF1D1A195" modified="2018-01-31" version="1">MTLRPPPVARARTPALAAVSVALALLGPPAPARAAGTGPWTAAPAAGTADARRAGDGGAPAAGGRASFYVEGAPGTVSEDRLSVVNPGERPQTVELRATGPWISLAAPRVSVPPRTRADVPLTVAVPAGQPPGAHLAAVVATAPGREVRVPVAVRVSGPALSALSVEHLRVTGAGRGTEIHYALVNRGNTTLAPRLAIRGEGLFGEVLRTAPRTAPAELPPGARVRLTERWPDAPRLDRVRIGVTATAPDGTRAAASATYAPLPWLPPVLAGAGGLAVAALAVRLLRRRRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJA2</accession>
    <name>A0A2G1XJA2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_16315</name>
        <name evidence="13" type="ORF">CYQ11_11760</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51303">
        <property type="protein sequence ID" value="PHQ51303"/>
        <property type="gene ID" value="BLA24_16315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13471">
        <property type="protein sequence ID" value="PPT13471"/>
        <property type="gene ID" value="CYQ11_11760"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="327"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="446" mass="47989" checksum="33A6066F72EAC064" modified="2018-01-31" version="1">MALKITVIGTGYLGATHAAAMAELGFEVLGLDVVPEKIETLSRGEVPMYEPGLEDLLRKHVAGIEGSTGRLRFTTSWEEVGEFGDVHFICVNTPQKQGEYACDMSYVESAVTQLAPWLRRPALVVGKSTVPVGSAARLAPLLTKLAPAGTDVELAWNPEFLREGFAVRDTLHPDRIVVGVAGERAEKVLREVYAVPIGEGSPFVVADYPTAELVKTAANSFLATKISFINAMAEVCEAADGDVAKLAEAIGHDERIGRKFLRAGIGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRGHMVELARETVGGSFLGRRVAVLGATFKPDSDDVRDSPALNVAGQIHLQGGQVTIYDPKGMENARQVFPTLSYAPSALEACRGAHVVLHLTEWSEFRELDPAALAEVVATPRVLDGRNALDAATWRAAGWTFRAMGRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD7</accession>
    <name>A0A2G1XJD7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimI</name>
        <name evidence="2" type="ORF">BLA24_14995</name>
        <name evidence="3" type="ORF">CYQ11_13075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51347">
        <property type="protein sequence ID" value="PHQ51347"/>
        <property type="gene ID" value="BLA24_14995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16530">
        <property type="protein sequence ID" value="PPT16530"/>
        <property type="gene ID" value="CYQ11_13075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="163" mass="18138" checksum="F81BF378DBB54D50" modified="2018-01-31" version="1">MRWWDIAPVLELERALFPHDAWSKGLFWSELAHARGAGANRRYVVAETVADDKTRIVGYAGLAAVDGTGDVQTIAVDRDYWSTGLGARLLSELLTTATAFECREVLLEVRVDNTRAQRLYERFGFEPVGVRRGYYQPGNVDALVMRLSDPPTAVQGMPHGSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD8</accession>
    <name>A0A2G1XJD8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16075</name>
        <name evidence="2" type="ORF">CYQ11_12000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51368">
        <property type="protein sequence ID" value="PHQ51368"/>
        <property type="gene ID" value="BLA24_16075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16509">
        <property type="protein sequence ID" value="PPT16509"/>
        <property type="gene ID" value="CYQ11_12000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="100" mass="10477" checksum="D090424BC8E1F991" modified="2018-01-31" version="1">MDTFADRLRTLPQSRLSRGAAAEALALAREFAAWTQRIEEPQAPDVREMPDAGMFAAADQVAVAGHDLAEALAACDTAPEGLGIAEAVARVAEAGRRCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJF4</accession>
    <name>A0A2G1XJF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16360</name>
        <name evidence="2" type="ORF">CYQ11_11715</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51311">
        <property type="protein sequence ID" value="PHQ51311"/>
        <property type="gene ID" value="BLA24_16360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13463">
        <property type="protein sequence ID" value="PPT13463"/>
        <property type="gene ID" value="CYQ11_11715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="32555" checksum="BC0B4A4CF572C7D2" modified="2018-01-31" version="1">MAIRTWAPPGPYDLGRTLGVLARGPGDPAYRVTPDGAVWRASRTPQGPGTLRVSAADGEVHAEAWGPGADWLLETLPALLGATDDPAAFTPRHRLLHETHRRNPGLRLARTGLVLESLIPSILEQKVTSDEAYRAWRLLLQRHGEPAPGPGPRMRVMPDPRAWALIPSWDWHTAGVDSKRSATILRAARVASRLEEAAGMADTEASARLQLIPGIGPWTAAETLQRSNGAPDAVTVGDLHLPKIVGYALTGARGTDDEAMLDLLTPYEGQRHRACRLILLSGVVPPRRAPRFSVRDFSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL3</accession>
    <name>A0A2G1XJL3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">12-oxophytodienoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13875</name>
        <name evidence="3" type="ORF">CYQ11_01570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51416">
        <property type="protein sequence ID" value="PHQ51416"/>
        <property type="gene ID" value="BLA24_13875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11757">
        <property type="protein sequence ID" value="PPT11757"/>
        <property type="gene ID" value="CYQ11_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="40480" checksum="8F8E310A29F38F1E" modified="2018-01-31" version="1">MATTTPATSGDALPSRAARLLGRPLTLGDLTLKNRIAMAAVTRRHSPGGVPGEDVAAYYARRAAGGAGLIVTEGTYVGREAAAAYDRVPHFHGEQALAGWARVVERVHEAGGRIMPQLWHTGVARTDEFAAEGAPAETPSGIGLDGRPHGKAMTQADIDGVVEAFARAAADAERIGFDGVELHGAHGYLIDDFLWQGTNRRSDAYGGDAASRARFATEVVAAVRAAVSPGFPILFRFSQWKVDHYDTRIAQTPQELELMLSPLAEAGVDAFHASTRRYWLPEFEGSDLNLAGWTKKLTGKPSVTVGSVGLDQQFIGPRGGSGPAGVTGIAPLLDRLERDEFDVVAVARAIVADPQWPTKALEDRLEEALPYDVSRLGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJP4</accession>
    <name>A0A2G1XJP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13690</name>
        <name evidence="4" type="ORF">CYQ11_01385</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51447">
        <property type="protein sequence ID" value="PHQ51447"/>
        <property type="gene ID" value="BLA24_13690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16278">
        <property type="protein sequence ID" value="PPT16278"/>
        <property type="gene ID" value="CYQ11_01385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="427" mass="44295" checksum="09F46B08986CC615" modified="2018-01-31" version="1">MRGGRSLGRRFAWLRAAYTVSAYGTGLGFGAFSLIAIFVLHAGPTEVSVLAAAGLAVGAVVAVPLGPWVEFRRKRPVMVAMDLARFAALMSVPVAFALGRLTFTQLLVVSVVVAAAKIAFTAASGAYLKALVRPEDLIVANGRFEATTWTATMLGPPLGGAAIGLFGPVTTVVADAVSYLLSAAGICAIGGREPRPARAGAPARLRPGDLLDGWRHILAHPTLRPLFFNTILVNGLIMATAPLAAVLMVGRLGFAPWQYSLAFAAPCVGGLIGSRLAPRLAARFGRPKVLLAAGTLRACWPVGLAFICPGTAGLVLVMAVQLGLVTCVGVFNPVFATQRLAQTGQDRVARTLSAWSIAGNATTAVMTALWGLLAGVTGARAAIALAGLLMLATPLLLPRHDRSTRHGRTPITAPALRGVRRGSRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK45</accession>
    <name>A0A2G1XK45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein MutT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_13020</name>
        <name evidence="6" type="ORF">CYQ11_17380</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51613">
        <property type="protein sequence ID" value="PHQ51613"/>
        <property type="gene ID" value="BLA24_13020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14406">
        <property type="protein sequence ID" value="PPT14406"/>
        <property type="gene ID" value="CYQ11_17380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="15305" checksum="F286385439AA6845" modified="2018-01-31" version="1">MSGAPVLAAGCVLWRATAPGELELALVHRPKYDDWSLPKGKLKRGETARACAVREVLEETGMRCALGAALPMSRYESEGRPKEVRWWAAEALDGAFEPSREVDRLLWLAPAEARARLTHDRDRPLVDALLTVLSGGDAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK67</accession>
    <name>A0A2G1XK67_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">BLA24_13045</name>
        <name evidence="7" type="ORF">CYQ11_17405</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51616">
        <property type="protein sequence ID" value="PHQ51616"/>
        <property type="gene ID" value="BLA24_13045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14409">
        <property type="protein sequence ID" value="PPT14409"/>
        <property type="gene ID" value="CYQ11_17405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="28154" checksum="082C4CEEF1717E75" modified="2018-01-31" version="1">MADAPYKLILLRHGESEWNAKNLFTGWVDVNLNEKGEKEAVRGGELLKDAGLLPDVVHTSLQKRAIRTAQLALEAADRHWIPVHRSWRLNERHYGALQGKDKAQTLAEFGEEQFMLWRRSYDTPPPALEDGTEFSQSDDPRYASIPSELRPRTECLKDVVVRMLPYWYDGIVPDLLAGRTVLVAAHGNSLRALVKHLDGISDADIAGLNIPTGIPLAYELDADFRPVVPGGTYLDPEAAKAAIEAVKNQGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKH7</accession>
    <name>A0A2G1XKH7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12515</name>
        <name evidence="3" type="ORF">CYQ11_17520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51649">
        <property type="protein sequence ID" value="PHQ51649"/>
        <property type="gene ID" value="BLA24_12515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14427">
        <property type="protein sequence ID" value="PPT14427"/>
        <property type="gene ID" value="CYQ11_17520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="337" mass="34257" checksum="028237665D3944EB" modified="2018-01-31" version="1">MRAVRLHAFGPAENLAYEETATPVPGPGQVRVTVAAAGVHLVDAAQRRGDPNGPYGLPELPVVPGREVAGTVDALGEGTDPRWLGRRVVAHLGRLSTGGGYAELAVVDAARLHEIPDGLDEAQAIAMIGTGRTALGILGFTELTGDDVVVVTAAAGGIGSLLVQYAKNAGATVVGLAGGPAKVRHVRDLGADLALDYTDPDWVRAARTALAGRAATVVFDGVGGDAARDAVGLLGRGGLHLVFGWSSQGVTGEGPGAPDPRELAEHGITSRGVLGPAMLERFGGGDVGLRRLEEESLARAAEGAVVPAVQRFPLAAAAEAHRALETRGTVGKVVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKK6</accession>
    <name>A0A2G1XKK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_11325</name>
        <name evidence="7" type="ORF">CYQ11_02560</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51679">
        <property type="protein sequence ID" value="PHQ51679"/>
        <property type="gene ID" value="BLA24_11325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11928">
        <property type="protein sequence ID" value="PPT11928"/>
        <property type="gene ID" value="CYQ11_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="42051" checksum="9F8C8D5C5194E670" modified="2018-01-31" version="1">MRALTWHGRRDVRVETVPDPKLELPTDVIVRVTSTGVCGSDLHLYELLGPYLDPGDVLGHEPMGIVEEVGPEVTSLVPGDRVVVPFNVSCGTCFMCGQGLHSQCETTQVRERGKGAALFGYSKLYGQVPGGQAQFLRVPFGDTLPVKVPHGPPDERFVYLSDVLPTAWQAVEYAAVPAGGSLTVLGLGPIGDMAARVALHRGAGQVIGVDLVPERLERARARGVTTLDLREHGKDLVAAVRELTGGRGTDAVVDAVGMEAHGAPLAQAAHQFVGLLPDALAQKLMDHAGVDRMAALYTAIEAVRRGGTVSLAGVYGGMADPLPMMTLFDKQIQLRMGQANVRRWVDDILPLLDDADPLGVQGFATHILPLEEGPKAYKAFQAKEDGMIKTLLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKK7</accession>
    <name>A0A2G1XKK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11505</name>
        <name evidence="3" type="ORF">CYQ11_02740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51711">
        <property type="protein sequence ID" value="PHQ51711"/>
        <property type="gene ID" value="BLA24_11505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11960">
        <property type="protein sequence ID" value="PPT11960"/>
        <property type="gene ID" value="CYQ11_02740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="15940" checksum="0C438ACFD5EFF234" modified="2018-01-31" version="1">MSPGRHARGRAGARRAAYDVRHGRLQRSMSLLTAAGSAVTAAEIFLEHDRAGFGNRVMWWPVALGPVGVVAGLAGFADARAARTALPLASAAIVANGLQGTYLHVRGIAQKPGGWRMARYNIELGPPLFAPLLMSMVGGMGLLASALRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL9</accession>
    <name>A0A2G1XKL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CbtB-domain containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11925</name>
        <name evidence="3" type="ORF">CYQ11_03165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51783">
        <property type="protein sequence ID" value="PHQ51783"/>
        <property type="gene ID" value="BLA24_11925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12030">
        <property type="protein sequence ID" value="PPT12030"/>
        <property type="gene ID" value="CYQ11_03165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="7675" checksum="EFC8E0D95B93936A" modified="2018-01-31" version="1">MAQSAAPVSGSPAIPEIAPISLKAIAPWAAFVGVLMLVLLYFVGAEQGATALISGEGVHEWVHDGRHLLGFPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKP3</accession>
    <name>A0A2G1XKP3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12055</name>
        <name evidence="2" type="ORF">CYQ11_03295</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51808">
        <property type="protein sequence ID" value="PHQ51808"/>
        <property type="gene ID" value="BLA24_12055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12054">
        <property type="protein sequence ID" value="PPT12054"/>
        <property type="gene ID" value="CYQ11_03295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="51627" checksum="A9DF48CF0E7A9BAF" modified="2018-01-31" version="1">MFDPDIAPSGTLLGLLQRGRGDGTLHALAAPRAEALAALNHCVLRDPRRDWQVENRSLYYARLYLDLDGGLDEIERHLFHPDDLFDTAEERTGLALAVLGHLASYGRDDALALLRRYAATGGNWAWALDELALRDDDAGLLALGAPVLARFPHTPEGEAALATAVRDAFEPRPWRLWAEDRRAPETAARVRAAQEQGSFDRWQRQLRPSGPRPGWSVREVLDWAQEGLLLHPAQHRHVPATRCLTAVAGPEDRGEIIEAAAFGADAARATALRYLAEHHDPQALDLIETAAADPARLVADAAVTAFERMRSTAALDRARVWVHRTDALGGAAAGMLACRGAAYDSSLVLGALRRTVRAEGCDAPVLWDLVDGAGRLSIGCAAPVLRHVYRETSSSHLRGRAARALAATDPAFATGFAVECLWDCEESTRELAARHATTADARVVDQLRRLAADPAEEAEVQTAVRSRFEPETPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKP8</accession>
    <name>A0A2G1XKP8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11735</name>
        <name evidence="3" type="ORF">CYQ11_02975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51751">
        <property type="protein sequence ID" value="PHQ51751"/>
        <property type="gene ID" value="BLA24_11735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11999">
        <property type="protein sequence ID" value="PPT11999"/>
        <property type="gene ID" value="CYQ11_02975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758499" evidence="1">
        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="172" mass="17684" checksum="734C8FD0C61CD91E" modified="2018-01-31" version="1">MRVTKFTTAAAAAVCGSLALGIAGPALADGLASEPAVVESAPGSAADRLDPIGGLGDTLSLGSRIGTEARSRTVDLQRLQELRQRLRESADRLHTAVRAQTPARAADPVSDVKGQLDKLVKDVTDLLAAVQAKDVAKVTTLVNTVVADLQALLTSVPKLLTNAAPLPVPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU1</accession>
    <name>A0A2G1XKU1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1348 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11965</name>
        <name evidence="2" type="ORF">CYQ11_03205</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51791">
        <property type="protein sequence ID" value="PHQ51791"/>
        <property type="gene ID" value="BLA24_11965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12037">
        <property type="protein sequence ID" value="PPT12037"/>
        <property type="gene ID" value="CYQ11_03205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="17272" checksum="B4C6ADF6F756CF57" modified="2018-01-31" version="1">MPDTRPPCPPFTAETALRKVRAAEDAWNTRDPERVALAYTEDSEWRNRDVFLTGRTEIVAFLRAKWERELDYRLRKELWAFTGDRIAVRFEYEWHDAAGQWYRSYGNENWEFDANGLMRRRFASVNDLAITERERRVLPPAGSSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKV4</accession>
    <name>A0A2G1XKV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo alpha-1,4 polygalactosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11785</name>
        <name evidence="4" type="ORF">CYQ11_03025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51857">
        <property type="protein sequence ID" value="PHQ51857"/>
        <property type="gene ID" value="BLA24_11785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16321">
        <property type="protein sequence ID" value="PPT16321"/>
        <property type="gene ID" value="CYQ11_03025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_114" evidence="2">
        <location>
            <begin position="76"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="299" mass="32480" checksum="9F255A46BDD8FCE5" modified="2018-01-31" version="1">MAGCSSSSSEPGDEAPEAGAERTARPGATGTPDASGTADTPSASPGSPSASPGAPSASPGTPSGAPARWRPRPGTRWQWQLDGTVDTSVDVPVYDIDGFENSADTVAELHARGRKVICYVNAGAWEDFRPDQAKFPSALRGRKNKGWNGEKWLDIRRLDVLRPLMAGRMEMCRQKGFDAVEPDLTEGFRNDTGFPLTAGHQLAFNRMLVELAHERGLAIGLKNDLDQIPELVRDFDFAVNEQCAQYKECEKLAPFVQGDKAVFHVEYDLEPGAFCGTAKRLGLSSMQKKLDLDAWRRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLE5</accession>
    <name>A0A2G1XLE5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name evidence="3" type="ORF">BLA24_09155</name>
        <name evidence="4" type="ORF">CYQ11_27765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52084">
        <property type="protein sequence ID" value="PHQ52084"/>
        <property type="gene ID" value="BLA24_09155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16164">
        <property type="protein sequence ID" value="PPT16164"/>
        <property type="gene ID" value="CYQ11_27765"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="103" mass="10994" checksum="B453548ED388F3CE" modified="2018-01-31" version="1">MIPGEILCAPEPVRLNEGLHRTRLTVLNRADRPVQVGSHYHFAEANPGLDFDRPAAHGKRLDVAAGTAVRFEPGIPVEVDLVPIGGKRVVEGLRGACAGPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLK2</accession>
    <name>A0A2G1XLK2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52097">
        <property type="protein sequence ID" value="PHQ52097"/>
        <property type="gene ID" value="BLA24_09235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="159"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="277" mass="29534" checksum="3537F822B7A9D0F6" modified="2018-01-31" version="1">MTPVRCGVLAVLERPERPVQLNLDPAASLRPGSTTDVPWPDAVDKPAEGTLDLWLLHMPDPWLLGTALDQSPLDERERAQAAGFVHAVDRAKYVASHLTLRRILGAYLGMPAGEVRFFREECPCCGKPHGRPAVTAPDAPHFSMSHGGNLVLIGVAAQPVGVDTEQVPAAHTVAGVAEALHPLEHREVMAAPAVRRPAVFTRLWVRKEAYLKGLGTGLGRSPDLDYLGNGGPGTPPWPTGWTIVDVPVGAGHAAAAVRGEITSRYDVRRLAPEGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLK9</accession>
    <name>A0A2G1XLK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">TROVE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_09230</name>
        <name evidence="7" type="ORF">CYQ11_27840</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52096">
        <property type="protein sequence ID" value="PHQ52096"/>
        <property type="gene ID" value="BLA24_09230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16176">
        <property type="protein sequence ID" value="PPT16176"/>
        <property type="gene ID" value="CYQ11_27840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="PTHR14202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="SSF140864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="5">
        <location>
            <begin position="24"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="543" mass="59922" checksum="574EFAB3EAF2FDE4" modified="2018-01-31" version="1">MARFNTRTTKPSPASPIASTGERTRTHEGAAGHVRDAKSELFLLAVANLVGTGAFYEKAEDRDDRYAGLVRRLAVEDPEWTVAFLRWLRDGAHMRTAALVGAAEFAAERVRRELPGHSRQAVDAVLQRADEPGEMLGYWTAHHGRAVPKPVKRGIADAVRRLYSQRSLLKYDTDSRAYRFGDVLSLAHPAPDPAKPWQAALFRHAVGRRRGRDEDIPEELATLRRRAALMRLEPAERRALLRRDGAADVLREAGMTWEALAGWLQGPMEAAAWEAVIPSMGPMALVRNLRNFDEAGVSDEVAERVAARIADPEQVTASRMFPFRFWAAYKHTSSLRWAHALEKAIGASLANVPALPGRTLILVDRSPSMFPGYVFSTPHTSDIPLAEQAALFGAALALRAERPTLVEFGMRSNAVDVPRGGSVLKLVERFGEIDGTDIPLAVRRHFAGHDRIVVVTDEQTRPGWLPSNAHAYGGMPETMIDDLVPRDVPVYMWNMAGYRAGATPSGGDNRHAFGGLTDAAFRMIPLLEAGRTAHWPWEDGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR1</accession>
    <name>A0A2G1XLR1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_09365</name>
        <name evidence="10" type="ORF">CYQ11_27975</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52121">
        <property type="protein sequence ID" value="PHQ52121"/>
        <property type="gene ID" value="BLA24_09365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16201">
        <property type="protein sequence ID" value="PPT16201"/>
        <property type="gene ID" value="CYQ11_27975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2050"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1015"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="2396" mass="257024" checksum="2B547137D2AF4829" modified="2018-01-31" version="1">MRHHQAETVPAELPLLAAQSGILYAQALAPDNPVYNTGDCVEIDGPLDAELFERALRQTVREAETLALVVTAGDPPAQRVEAGRDWPLHRLDLRGNPRPDAEAEAWMRADLAQPVDLTEGPLVTQALIRLADDRFWWYQRVHHFAVDAYALTLIGRRVAEVYTALAAGDAPSPNPFGTLRELVEDEAQYTGGERHAADGAFWRERYADRPEPVSLSDRPAAPAGSVLRHDAALPAGSLSRLEDAARAVKATWAELLIAATAGYVHRTTGARDVVLGLPLMNRRGPAALRTPAMTVNVMPLRITVRPQDTGAELLRRVVLEVRAVRRHQRYRLEDLRRDLGLTAAEQPLFGPMVNIKPFEGDLEFDGLPGVVRNLAAGPVDDLALAVIPAPDGSVRLGLDANPARYDLPSLAAHEHGLRRYLDGLTDLLLADPQRPVGTIDLLDADEIRAATAGRTEPAPDRTLPELFAEQAARTPDATAVRSGATALTFAELDTAANRLAHELRHGGVRPGAAVALALPRGADTVVALLAVLKAGGVCQPLDLGHPGRRIAAVLDDTRPGCLIGTASTVRSLPDHGIPTLLLDDPATRARIDARPGTAPAAPALQQAAYVIHTSGSTGRPKGVLVTHASLANLHAGHGGDHIAPAVERTGRQRLRIAHTASFAFDASWDPLIWMVHGHELHLLDDTDYRDPAAATAYLHEHRVDYLDATPSYVEALIAEGLLDEGRHHPALVVVGGEAVPEPLWQRLATTEGLSPINLYGPTETTVDAYYWLPGPTQDAPTTGRPVRGSRAYVLDGSLRPTPPGVPGELYVAGACLAAGYLGRPDLTAERFTADPFGALHGESGARMYRTGDLVRRRPDGTLEFLGRADDQVKIRGFRVELGEIQATLAGHPEVAQAAVVARDTPTGKRLAAYAVLTEGATAGPRHLTDHLARLLPGHMVPADVVLLDALPRTANDKLDVRALPDPRPTGESTGAAYRAPGCREEESICLLFAQVLDLDAPVSADANFFDLGGHSLLAGRLAATIRDREDEGVTLADVFRNPTPAALAKLIANGTAPHADGERPALAPLPREERMPLSPAQKRLWFMYRLEGPSPTYNIPLLLTLTGPLDQDALRLALGDVTERHETLRTVYPATDNEPYQRILGPDQARPELHLAPASASPAEAVRHCFDLAAEPPLRVTLFTDGAESHTLLLLLHHIAGDGASTTPLARDLATAYAARAEGRTPGFAPLAAQYADYTLWQRDLLGTPAAPGVFAGPQLDHWRKSLAGLPDLLELPTDRPRPAVASSAGDTVPFHLDPDAHAAVRTLARTTGTSVFMVVQAALAALLTRYGCGTDIPIGTPVAGREDEATADLVGFFVNTLVLRNDTSGAPAFRTLLDRVRATTLAAYEHPDLPFDWLVEDLNPPRSLARHPLFQVMLAWQSLPDAEFTMAPGLTARMAAVPSGTAKFDLTLNAGEQPGGGIAGFLEYRTDLFDAATVKRLSTHLARLLTAAAADPDTPVTRLPLLDADETRQALVDWNAGPSEQVRAPRTLVELYEDAARRHPGRTAATCDGASLTYAGLSARANRLARLLAGRGIGPGAIVALALPRSLDLVVGLLAVAKSGAAYLPLDPDYPADRLAYMLQDAAPAAVVTDTATAARVPAHDLPVVLVDGTEAEGLAPTDLSDDDRTRPQRPGDVAYVIYTSGSTGRPKGVPVTHHNVTRLFSATDHWFGFDEKDVWTLFHSYAFDFSVWELWGALLHGGRLVVVPHLVSRDPAAFLRLLADERVTVLNQTPSAFYQLSAADRENPGSDLALRYVVFGGEALELGRLDDWYDRHPDDAPTLVNMYGITETTVHVSYVALDRESAAAGTSSTIGVNIPDLRVYVLDGHLQPVPPGVTGEMYVAGEGLARGYLGRHALTAERFVADPFAHLFGERGSRMYRSGDLARRRPDGTLEYFGRADHQVKIRGFRIELGEIEAVLADHPDVADAAVVVREDTPGDKRLVAYAVPARETTPALLREHTTGELPVHMVPSAVVLLEKLPLTANGKLDRKALPAPDLAAAVTEGRAPRGPREEQLCAIFADVLGLPRVGVDDNFFDLGGHSLLAVRLAGRVKDALGAEVGIGTVFQAPTVAALDAALDAAEGTDALDVLLPLRPANDGDKAPLYCVHPAGGLSWCYAGLIRHLPADVPIYGLQAQGVGPATAAEPLPGTLEELAAHYVGRLREVQPEGPYRLLGWSTGGIIAHAMATRLQDLGAEVELLAVLDAYPAEGFRELPVPDQAEALEALLAMGGYGPDSLEGKPFELAHVTEVLRREGSPLASLDDATIEALNRTYLNTNHLVRAFDHRVFEGDVLFFRATVETIDDTLTPETWTPYVTGRIDNTNVACSHKDMTLPEPIAHIASVIADRLQNLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR4</accession>
    <name>A0A2G1XLR4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000095">
        <property type="protein sequence ID" value="PHQ52188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52188">
        <property type="protein sequence ID" value="PHQ52188"/>
        <property type="gene ID" value="BLA24_08995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4142" evidence="2">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="349" mass="38267" checksum="E779F011838445A0" modified="2018-01-31" version="1">MTGPAGLRAPPMTPRQAGAPPRCSVGWTGRPRPAVARPARGIHLLREGRRLVRPRRPSPRRTPRTPAAEEKRSSEDANATPGHDSGGGPRPGRSDGPRHGARRPRRRPCGRQGRRRAHQAPPGRHGGGRRGRDARRHAVARCVKDAGRVLVRDHTRMDEQVRKVASRLRVSLPTTTTAEQRKQLKDLRAKARTADYDRLWVKTYGTAHVKTLALLDDEIAHGKNNDVRELARKLRPVVQSHLKMLFQCGAGGHGGRKDQGDQQGGDNGREHGQGNGQGQGRDTGRDNGRDQGRDRTHASSRDHGRTHDRHTAIATTATTATSRTPFLPGHRGPGQEPPRDRCHGCGDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR7</accession>
    <name>A0A2G1XLR7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52185">
        <property type="protein sequence ID" value="PHQ52185"/>
        <property type="gene ID" value="BLA24_09670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="38" mass="3847" checksum="79312E54CC0A4D7B" modified="2018-01-31" version="1" fragment="single">MLYTSGSTGRPKGVVVSHGAFANLSLSHAKFGVGPGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM11</accession>
    <name>A0A2G1XM11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">EamA/RhaT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_08885</name>
        <name evidence="5" type="ORF">CYQ11_04140</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52263">
        <property type="protein sequence ID" value="PHQ52263"/>
        <property type="gene ID" value="BLA24_08885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12195">
        <property type="protein sequence ID" value="PPT12195"/>
        <property type="gene ID" value="CYQ11_04140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="50"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="189"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="35791" checksum="DE2B0DE2E310996C" modified="2018-01-31" version="1">MSTVATPTPSASPSSPSTSAPTASPASPAPGKGQEQGPRRIDWRIRFGVLSLIWGFSFVFIKLGTDGFAPPYVSFGRMFFGALVLMAALLVTRQRLPRSARTWGHLTVAAFLCNALPFTLFAYAELTISTTLAGICNATTPLWGMVLSLVALSEDRPTRRRFAGLGLGFVGVLIVLGVWQGFSGQDPKGTGLALIAAASYAVGWIYVRRTLSGTGDSHLAMSGSQLLLGAVQLGVVAPLLSPLPTAFPTVPLLAVFALGALGTGLAFLLQYALVAEVGPTTATLTTYFIPVVSTTAGVALLGEGLSWNTPVGAVIVLAGAALTQGKGSTKAAGAKVVAAGSEPAKAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XME8</accession>
    <name>A0A2G1XME8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000082">
        <property type="protein sequence ID" value="PHQ52422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52422">
        <property type="protein sequence ID" value="PHQ52422"/>
        <property type="gene ID" value="BLA24_07540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042925">
        <property type="term" value="F:benzoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004711">
        <property type="entry name" value="Benzoate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30199">
        <property type="entry name" value="PTHR30199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03594">
        <property type="entry name" value="BenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00843">
        <property type="entry name" value="benE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="498" mass="51969" checksum="5735F494CCE43BF7" modified="2018-01-31" version="1">MRRSDVFTQAVYILVGTNDLPFRTEAARKAHQPGRRCGPTSLAATAVRATTVPITAVHLTAVHLFVHGKAVDADRTHVIKFSTVPLIRHIRAVAPPSAVTAGFLAVLIGFTSSVAIVITAAETAGATSAQLTSWIFALGIGMGVTCVGLSLRYRAPVVTAWSTPGAALLATGLHGVSMPQAVGAFILSAVLVVVSGVTGWFERVMDKIPVPLASALLAGVLVQFGTGLFTKMQQNFAVVFPMFAVYLLCRRWLPRYAVIGALAIGIAASACQGSWRLGGLHLGLAEPVFVRPEFSWQVLVGVGLPLYVVTMASQNLPGVAVMRNAGYRTPVSPLLTWTGVVTALLAPFGCFGLNLAAITAAICMGEEAHEDPRRRYLAAVWAGLFYVTVGLFAGVVGWLLTAMPTALIMGIAGLGLLGTIGGSLSAALADEGMREPAVVTFLATASGMTLFGIGSTFWGLLAGVLATAVLRSRRRTATAVTPAPEPGREPARTLTMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMM7</accession>
    <name>A0A2G1XMM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_06980</name>
        <name evidence="7" type="ORF">CYQ11_27135</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52514">
        <property type="protein sequence ID" value="PHQ52514"/>
        <property type="gene ID" value="BLA24_06980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16050">
        <property type="protein sequence ID" value="PPT16050"/>
        <property type="gene ID" value="CYQ11_27135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="25484" checksum="48BD2CEDA1C02A07" modified="2018-01-31" version="1">MSRVLLIEDDRAVREGVTLTLRRRGHDVEAAPTGEAGLAALETFRPDLVLLDLMLPDKSGFEVCRRIRATQQIPIIMLTARGDDIDVVLGLEAGADDYIVKPARGEVLEARIRAVLRRAAPVDGAGCEPAPAAAEAHGDLVIDRAGLLVSKNGQDLPLAPSEMKLLLYLSATPGRVFSRQQLLEHVWEHSYHGDARLVDACVMRLRTKVEESTRSPKYIQTVRGFGYRFGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN00</accession>
    <name>A0A2G1XN00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SMC family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_07455</name>
        <name evidence="5" type="ORF">CYQ11_27605</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52596">
        <property type="protein sequence ID" value="PHQ52596"/>
        <property type="gene ID" value="BLA24_07455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16133">
        <property type="protein sequence ID" value="PPT16133"/>
        <property type="gene ID" value="CYQ11_27605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="590"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1044" mass="112252" checksum="FE81FF6AB115D648" modified="2018-01-31" version="1">MRLHRLTVTAFGPFGGTEHVDFDELSAGGLFLLHGPTGAGKTSVLDAVCYALYNEVPGTRQGSGLTLRSDHAEAGTPTEVVLELTVAGRRLEITRRPEQLRPKKRGAGFTKEKPHSALRERPPGGDWKGLSRSHQEIGEEIRQLLGMSREQFCQVVLLPQGDFARFLRAEDTARGKLLRSLFGTGRFLAVEERLAELRREAEAQVREGDERLLRLGHRMRQAAADPTLPEVGVPAPATATPAATGRGTEAARTAGGVPRTARGRATVPGPRAAEPPLAPGDPGLAEAVLEWAALARTGARERQTVAEAAVAAAEQVHRAAHDHADEVRELARSQRRHAEAEQRAAALRERRPEHDEVRRRLERALAAEAVAPALELRDKAEAGLLAAAAAERRTRQALPDAHRDGDAGHLAAAEHALREELGALTAARRAEARAAGLVRDLAELGRAAGADEEVLAETGEWLDAWETTRRDHRQRIDAAQEAVGLAERLGGQLEPARRRLQAARRRDELAREVTGAETRLLAAREDAAAAREHWLGLKDRRLRGMAAELAAGLTAGEPCAVCGAAEHPAPARPAAGHVDPAAEEAALQAHQRAEAVREEAAGRLRSLREARDVATAEAGPAAVDELARDVAEVERSLAAARDASAGLHEARQALAAAEAECERRRAAQEEARLRVAARSSRREQLARELRALEEELEQARGGEESVARRAARLEERLVLLAGAAEAAREAGRAADRLKEADAQLADAAYRAGFDTPALAAEALLSAVERRGLQERLDRWRSEEAAVAAELADRALTEAAARPPADPQAAQAAADAATGALRRASAEEATARSRCEDLDRLSAEAEADARRLAPLRAEHHRVAELSWLAAGTSARNERKMRLESYVLAARLEQVAAAATARLQRMSAGRYTLVHSDARTSGRGRSGLGLHVVDSWTGRERDTATLSGGETFFASLALALGLADVVTQEAGGTRLDTLFIDEGFGSLDEQTLDEVLDVLDSLRERDRSVGIVSHVADLRRRIPAQLQVVKERSGSAVRHRTAVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN15</accession>
    <name>A0A2G1XN15_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_07130</name>
        <name evidence="7" type="ORF">CYQ11_27285</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52539">
        <property type="protein sequence ID" value="PHQ52539"/>
        <property type="gene ID" value="BLA24_07130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16077">
        <property type="protein sequence ID" value="PPT16077"/>
        <property type="gene ID" value="CYQ11_27285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="275" mass="28982" checksum="7E6BD6B117F3E6C6" modified="2018-01-31" version="1">MKRCDPRTAVPAAAVTLVVLVALVVPYAAPLDEQAVDLGAKLLPPSWSHPFGTDEVGRDLLLRCVHGLRVSLLVGVAAAVVATVVGTAVGALAGALGGWADRAVMRVVDLFSSVPHLLLGIFVVAVLRPGVWPVIASVAVTHWLSTARIVRAELLSLRTRPYVDAAVSGGASRWRVTVRHLLPAVAPQAGLAAVLMIPHAVWHESALSFLGLGLPTHQASLGTMVQSARGSLLAGDWWPTLFPGLFIVLPTLAVAGLAGAWRERLNPRRRSELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN95</accession>
    <name>A0A2G1XN95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06165</name>
        <name evidence="3" type="ORF">CYQ11_03690</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52686">
        <property type="protein sequence ID" value="PHQ52686"/>
        <property type="gene ID" value="BLA24_06165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12120">
        <property type="protein sequence ID" value="PPT12120"/>
        <property type="gene ID" value="CYQ11_03690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="32727" checksum="E706237856C477BC" modified="2018-01-31" version="1">MPNVSRVQTYEHLTGQDFVPPGSPQVFFEPADTEIGVWVVKDLVTAGCSVLDLGSGSGAAAAAMARAGATRVHGVDSGAETVAWAEKHYASHDGDRRVTFALGDFAAMTTERLLATAPTPLPRPLIVTSNPPYVPLTLRADAQRRSISGGTDGLKWAPAIIGHGRELRSDLGLTIGSYSTPRKAVRLLEDAGYRVHAVTLCPLPLGEFTLSNIEQVLALEEAEEAVLWRTDGGTPRYFIVGLACRWTAGAGDGEAGRLSGEGLLDLLRTAARSHTSRLEALDGARPDGWQGPVRVLDLPVAEARHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNM0</accession>
    <name>A0A2G1XNM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05565</name>
        <name evidence="3" type="ORF">CYQ11_02025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52739">
        <property type="protein sequence ID" value="PHQ52739"/>
        <property type="gene ID" value="BLA24_05565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11835">
        <property type="protein sequence ID" value="PPT11835"/>
        <property type="gene ID" value="CYQ11_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="205" mass="23776" checksum="C2D22DB616005E97" modified="2018-01-31" version="1">MDHPTTPTIELVERDGEVTLSIGGEQAMQAWERDLMWASADMLCEYGQDFYEVGLGLGLSALRIANNPATRSHTVLELFDEVEDLFRARHPHLPDNLTIERGDFFRRVFELPSESVDGMFFDPALDMDVWTNADLWARTMPEVVRVLRPGGVFIPFFSTKPELRWQYLPHFRTIRVERHPYVAYDTTEYTHGTRGDAYVQCFRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNQ5</accession>
    <name>A0A2G1XNQ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_04685</name>
        <name evidence="7" type="ORF">CYQ11_28845</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52868">
        <property type="protein sequence ID" value="PHQ52868"/>
        <property type="gene ID" value="BLA24_04685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11472">
        <property type="protein sequence ID" value="PPT11472"/>
        <property type="gene ID" value="CYQ11_28845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="707" mass="74927" checksum="E0F73910C48582E2" modified="2018-01-31" version="1">MTTTDTHCPYCALQCGMRLRRARPGTPAGAPSVEVDERPGFPVNEGALCGKGRTAPAVLARAARLTAPLVRDPRSGELCETSWERALDRVAAGLRESADRHGREAVGVFGGGGLTNEKAYLLGKFARVVLRTPNIDYNGRFCMASAAAAHRAAFGVDRGLPFPLEDVATTGCVILVGANPAETMPPALRYFTRMRAVGGRLIVVDPRRTRTAEHADLHLRPAPGTDLALALGLLHLVIADGRLDEEFIAARTTGFEQARAAAMAHWPERVEQITGVPVPAMREAARLFAAAPTGMVLTARGAEQHSKGTDTVRAWINLCLATGKAGRPGSGYGALTGQGNGQGGREHGQKADQLPGYRSLTDPAARAHVARVWGVDPADLPGPGASAYELLDRAGTAAGVRALLVMGSNPVVSAPHAAHVTERLTALDFLAVSDVVLSETAELADVVLPAAQWAEETGTTTNLEGRVILRQAALPPPDGVRTDLTVLRELAARLGHGQGFPDDPEEVFDELRRASAGGPADYAGITYARVRAENGVFWPCPGTTHPGTPRLFLDRFATADGRARFAAVTHRPAAEEPDADYPLHLTTGRVTAQYQSGAQTRRVPELNAAAPGPFVEVHPRLAERLGVTEGELLSVTSRRGRSLAPARITGTIRPDTVFMPFHWAGPGRANTVTNPALDPESKMPEFKVCAVRVEKAAPAGRERSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNQ6</accession>
    <name>A0A2G1XNQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52872">
        <property type="protein sequence ID" value="PHQ52872"/>
        <property type="gene ID" value="BLA24_04715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="50" mass="5506" checksum="EE28C08AA0F92E35" modified="2018-01-31" version="1">MLFLAAALLVLGILSGTVAHIPLTVSVFSAMAICGWLLLFAVRERHRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR2</accession>
    <name>A0A2G1XNR2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04745</name>
        <name evidence="4" type="ORF">CYQ11_28790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52877">
        <property type="protein sequence ID" value="PHQ52877"/>
        <property type="gene ID" value="BLA24_04745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11464">
        <property type="protein sequence ID" value="PPT11464"/>
        <property type="gene ID" value="CYQ11_28790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304928" evidence="2">
        <location>
            <begin position="30"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="449" mass="44774" checksum="4840D0E7348EF5D4" modified="2018-01-31" version="1">MPRTSLAPPLLTVAGTTLVAAAPAPVAPAPAVPCGPARPRPRDRRPSAARSGYARIFSVPGARAFTAWNLLARVPMGMFGVGAVLMITAARGSYALAGAVTATGLAATAVVAPWTARLVDRYGQARVAVPATVIAALGSLSLVSCVRSGAPAWTLFLSYVATATAPNTGGMSRARWAHLFRGDPGALHTANAFEQAVDEVCFMLGPLLATFLCTSLFPEAGTLVGVAMMLTGTVLFAAQRRTEPPVAPRPSVPGTLLRGNPGLAAVLAVFVCTGAVFGSLEVVTLGFADSLGHRPAAGAVLALQAAGSCAAGLLYGLARPAGPAVARFRRCLAGMAALAPLPLLAASTGGLPTLGAALLLTGMATAPTMVTGMNLVQGRTPTGRLNEGMTLAVTGLLAGIAAGSAAGGWSVEHFGASAGYGVPAVAAALALLTATAGRSVLVADETTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNY8</accession>
    <name>A0A2G1XNY8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04595</name>
        <name evidence="4" type="ORF">CYQ11_28935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52965">
        <property type="protein sequence ID" value="PHQ52965"/>
        <property type="gene ID" value="BLA24_04595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11520">
        <property type="protein sequence ID" value="PPT11520"/>
        <property type="gene ID" value="CYQ11_28935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="38"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="416" mass="45910" checksum="87E8DDCE8F6C19CA" modified="2018-01-31" version="1">MTDHRFTVPLDHADPGGRTIEVFAREVVDPARAGERLPWLLYLQGGPGGKSPRPQNAATPGWLRHALRTHRVLLLDQRGTGRSTPVTARAAAEFRSAAELAAYLAHFRSDAIVADCELIRRRLCGDQPWESLGQSYGGFITLAYLSRAPEGLRACYVTGGLPGLSATADEVYARTYPRVRDKNATYYARYPEDAERVRRIADLLAREDVRLPDGDRLTVRRLRTLGLAFGMGDGFERVHWLLDEAFDGGGLSATFRYQVMALTGLVDNPLFAVIHEGASYGQGDKPTGWAAERALADFPEFAEDADPLLFTGEMMYPWMFREIAGLRPFAEAADLLAERADWPPLYDLGRLARNEVPVAAVVYHDDMYVDASLSLGTARAVGNVSTWVTDEWEHDGVAASGDRVLARLMDMVAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP01</accession>
    <name>A0A2G1XP01_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">zwf</name>
        <name evidence="10" type="ORF">BLA24_05185</name>
        <name evidence="11" type="ORF">CYQ11_28345</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52943">
        <property type="protein sequence ID" value="PHQ52943"/>
        <property type="gene ID" value="BLA24_05185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11395">
        <property type="protein sequence ID" value="PPT11395"/>
        <property type="gene ID" value="CYQ11_28345"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="205"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="500" mass="54621" checksum="57CB1D7EBD104D94" modified="2018-01-31" version="1">MTALQPPATAHGTSNRPGRPDDHVVVLFGATGDLARRKLLPGLYRLARAGLMPYRYRIVGSAPAASALTDEEFRAHARQAVTEFGAEQLSGAHWAAFESTLSFGAADPEDPQPLLAAVRAAEQAVGGSPRRLCHLAVPPSAFASVIGMLGRCGLAERARVIVEKPFGTDLASARALNETVHAVFDESRVFRIDHFLGKESVDNILALRFANGLFEPVWNRDHISHVQIDVPETIGIEGRAGFFEETGTFRDMIVTHLFQVLGFVAMEPPVRLEATSLRDEKAKVFEAMKPLDPAHVVRGQYAGYRAEPGVDPHSGTETFAALRVEVDNWRWAGVPFFLRSGKSLGRRRQVVALSFKEPPLRMFPVDAHTGGGPRSNTLVVDFDDPGWISARFLAKEPGPAMRLGPAAMTFRYADSTGRRRGLEGYERLLLDAMLGDQSLFTRADGIERLWEVSEPLFQAPPAVLPYAPGSWGPAAADDLVAPHRWYLPDIPVEDPGRGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP51</accession>
    <name>A0A2G1XP51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000069">
        <property type="protein sequence ID" value="PHQ52990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52990">
        <property type="protein sequence ID" value="PHQ52990"/>
        <property type="gene ID" value="BLA24_04425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="127" mass="13832" checksum="2BB56891026E04F0" modified="2018-01-31" version="1">MATTPTTTAEPPDTAAPGRSPDAARPGSAGEHLVQRRLGTADRAGRFYDDQVLSHLNARMREFVARQEMFFLATADRRGTCDNTFRAGPPGFLRVLDDRTLAYPEYRGNGVLASLGTSRRTRTSGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP53</accession>
    <name>A0A2G1XP53_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000068">
        <property type="protein sequence ID" value="PHQ52993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52993">
        <property type="protein sequence ID" value="PHQ52993"/>
        <property type="gene ID" value="BLA24_04380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="59" mass="6153" checksum="B23A66610C464483" modified="2018-01-31" version="1" fragment="single">AMSLWPNKGDADPRPAQGSAYERVAAVAPRQPAVPEGAFGALRLPMLDVPVVPKKSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPG7</accession>
    <name>A0A2G1XPG7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03300</name>
        <name evidence="4" type="ORF">CYQ11_16990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53110">
        <property type="protein sequence ID" value="PHQ53110"/>
        <property type="gene ID" value="BLA24_03300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14338">
        <property type="protein sequence ID" value="PPT14338"/>
        <property type="gene ID" value="CYQ11_16990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="170" mass="18454" checksum="63E100F660911376" modified="2018-01-31" version="1">MSDAHEAPGPRPEPLRFFGTTWVDHDGGYALRRAGVAAGSLVAAVAGAFLLRFGYEGLAIAQVGGLVNLMVVVAFAVCSALGFRRTWDGFVRRPEAGATDAAAERSMHSIVMIGFVGVLLAYFFRSFVEAPGERLHRAEYEQESARHERRRSARTGNPAARASKGRRKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPK1</accession>
    <name>A0A2G1XPK1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF979 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02010</name>
        <name evidence="3" type="ORF">CYQ11_04370</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53143">
        <property type="protein sequence ID" value="PHQ53143"/>
        <property type="gene ID" value="BLA24_02010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12233">
        <property type="protein sequence ID" value="PPT12233"/>
        <property type="gene ID" value="CYQ11_04370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009323">
        <property type="entry name" value="DUF979"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06166">
        <property type="entry name" value="DUF979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="33296" checksum="D760D20E777F36E4" modified="2018-01-31" version="1">MIRAEWFFWLVGGVFLVMAAQMLADRTNPKRLGTAAFWALLGLGFCYSTGVADKSAPAEPLGAAVLVMICLAGFGFTGRGAARTTTAEERAASAARYGNKLFVPALTIPAVALVCAVVVKKVSAGGQPLLQKGSETVLGLGIGALIALVVGMVMLRERRLSIPVHAGRSTLESVGPVMLLPQLLATLGAIFALAGVGDQVRRGTTVLLPEGSVLLAVVVYCVGMFLFTAVMGNAFAAFPVMTAAVGWPVLVEQAHGDAPAVLAVGMLAGFCGTLVTPMAANYNIVPAALLELTDQYGPIKAQLPTAFVLLGCNIAIMSVFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ14</accession>
    <name>A0A2G1XQ14_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_02345</name>
        <name evidence="12" type="ORF">CYQ11_04710</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53335">
        <property type="protein sequence ID" value="PHQ53335"/>
        <property type="gene ID" value="BLA24_02345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16352">
        <property type="protein sequence ID" value="PPT16352"/>
        <property type="gene ID" value="CYQ11_04710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="222"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="287"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="443" mass="46810" checksum="BBC5668706AD04D1" modified="2018-01-31" version="1">MTVSLLLLAAALLLILANGFFVAAEFGLVTVERPEAERVAAEGDHRARTVVESLRELSFQLSGTQLGITITSLVVGMLAEPALGRLLTGPLTAAGLPDGAAPGVAVVTGMLLASAVQMVVGELVPKNWAVSRPLQVARFVAGPQSVFAHSFRPVISLLNAVANRMVRAMGVEPAEELASARTPGELVSLARHSARAGALEQDTADLFVRTLSLGGLTAQHVMTPRVKVSALQSTATAEDVLNLTRATGLSRFPVYRERLDEVVGMVHLKDALAVPGHDRLRTPVGRIAVAPMLVPGTLPVQPLLERLRSEQPIAVVVDEYGGTAGVVTLEDIVEELVGEVRDEHDAADAGRPELAPVVCEDGRPAWDADGGCRVDVLRRIGLEAPDGPYETVAGLVAGLLGRIPVSGDSAELPGWRLSVRHVGHHRAERVRFVRTGVAPGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQN7</accession>
    <name>A0A2G1XQN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01095</name>
        <name evidence="3" type="ORF">BLA24_22685</name>
        <name evidence="5" type="ORF">CYQ11_08105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50350">
        <property type="protein sequence ID" value="PHQ50350"/>
        <property type="gene ID" value="BLA24_22685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53557">
        <property type="protein sequence ID" value="PHQ53557"/>
        <property type="gene ID" value="BLA24_01095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12862">
        <property type="protein sequence ID" value="PPT12862"/>
        <property type="gene ID" value="CYQ11_08105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="516" mass="51758" checksum="0CD8B4DA5E9753B3" modified="2018-01-31" version="1">MSTEGGTPGGTPGKRRRKHSPLAVASVAAAVLLAGGGGAYWASTASDGGGGGGGGGEPGTSAADSSPPPLALDGYGRAPGSSGPGIAVGEPDPGGVRYRATGKLPDGPRTAAVYLPAREVTREEVADLAKALNVQGVPRLVQDTWTVGGTPDAAGPTLQVSRQGPGTWSYARYGVPGGAHCEHPPGAGPKRESGPAPGPGTDAAVPACPSFRGSPAPDPGAAGPVSEEKAKSVAAPVLKALGQGRAKTDARGVHGALRTVSAEPVLDTLPTYGWQTSLQVGADAQLTGGSGQLQMPRKATAYPMLTARQALDELNKGGGTGHAGIGGCATPAPLGDGSEDPCKDKPGKPEPVEVEGAVFGLSAQSVAGRSALVPSWLFTARIPGTPKDGATVTVAQPAVDPKFIEHHPSPGGPGGSPTATPPRSGPVPVESYRLDSDGRKLTLHFWGGVCSEYAASADQSGAAVTVKVTATEKEPGRYCVMMIKQFDTTVALDEPLGDRKVVDLTTGGPVRQLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9A8</accession>
    <name>A0A2G1X9A8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30330</name>
        <name evidence="3" type="ORF">CYQ11_23425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47812">
        <property type="protein sequence ID" value="PHQ47812"/>
        <property type="gene ID" value="BLA24_30330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15437">
        <property type="protein sequence ID" value="PPT15437"/>
        <property type="gene ID" value="CYQ11_23425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304530" evidence="1">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="23767" checksum="1D32BDC786D8C0BC" modified="2018-01-31" version="1">MLVAAAVCPCPPLLVPEVAAGAAPELDALRAACLDAVAVLAAARPDRLVVVGPAALQGRGPHPQGAVGSFRGLGVDLDVRLGPGGPAGERELPQSLAVAAWLLGRTEWAAAPVEGLGVGEPLDTERCVGVGRKLAAEAERVALLVMGDGSACRTVKAPGYLDERAEAFDARAARALAAADTEALAALDAELGLELKAAGRAPWQVLAGAGESAGLRGSLLYDEAPYGVGYLVAAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9D5</accession>
    <name>A0A2G1X9D5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30445</name>
        <name evidence="3" type="ORF">CYQ11_23540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47835">
        <property type="protein sequence ID" value="PHQ47835"/>
        <property type="gene ID" value="BLA24_30445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15460">
        <property type="protein sequence ID" value="PPT15460"/>
        <property type="gene ID" value="CYQ11_23540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="20456" checksum="D8522E6F4F0DC1DA" modified="2018-01-31" version="1">MPLIPEEPQIHESVPGPRAVAATGRTAPTPRPVPGPRPVPTRPGIPAAQRGPVPAVPSPRAPQDAAAGTRAATPQIQLIPASLEGALDAADEAVDLLLDTGRAPAEVLVLTTGDPHPWAAHELSFGEASYWAQQDAGDDVFYAAADADRLSPRPVVVVAVNGGTDELVARALPAAMNRAGALLIVCGDPQRVNGLLSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9P2</accession>
    <name>A0A2G1X9P2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine biosynthesis protein PhzC/PhzF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">PhzF family phenazine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30750</name>
        <name evidence="2" type="ORF">CYQ11_23845</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47889">
        <property type="protein sequence ID" value="PHQ47889"/>
        <property type="gene ID" value="BLA24_30750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15514">
        <property type="protein sequence ID" value="PPT15514"/>
        <property type="gene ID" value="CYQ11_23845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="24289" checksum="E475564ACF1A6E78" modified="2018-01-31" version="1">MTETLDPSCASLGLRVLNVFRGTSGGGGNPLGVVTNGAACPGEERRRALAARLGYSETIFIDDAERGVVDIHTPSVRLPFAGHPLVGAAWLLGPGVSVLRPPAGEVAVRREGEVIWVRGRAEWAPGRRTEQYGSVAEVDALPAPPPGEGWLYAWAWQDEKAGVVRARGFPRRGDSVVEDEATGASALVLTDELGRPLDIRQGVASRILTRPHADGTIELGGTVAPAGPAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9S3</accession>
    <name>A0A2G1X9S3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoadipyl CoA thiolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Thiolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_31575</name>
        <name evidence="8" type="ORF">CYQ11_24625</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47997">
        <property type="protein sequence ID" value="PHQ47997"/>
        <property type="gene ID" value="BLA24_31575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15623">
        <property type="protein sequence ID" value="PPT15623"/>
        <property type="gene ID" value="CYQ11_24625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="275"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ47997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="41006" checksum="C5AA3E2EFEA8936C" modified="2018-01-31" version="1">MNDRIRDVYIVDAVRTPVGKYGGALAGVRPDDLAAHVVRSLVGRTPELDPARVDDVVLGNANGAGEENRDVARMAVLLAGLPVAVPGATVNRLCASGMEAVVQAYRAVAVGDASVVVAGGVESMSRAPWVLPKAERAFPVGHQQLYSTTLGWRMTNPAMPERWTVSLGEGAELVADKHGIGREAQDAFALASHEKAARAWKDGAFEAEVVPLPGVELPRDECVRDTTSAEALAALKPAFRRSGGTVTAGNSSPLNDGAAALLLCDEEGLRATGREPLARVRASAVTGIEPDLYGLGPVEAVRRVLAKAGRGFGDLTHVELNEAFAAQALGCLAEWPELDPALVNQRGGAIAIGHPLGCSGARLAGSLAHQLAAAGSGTGLATLCVGVGQGQALILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Z2</accession>
    <name>A0A2G1X9Z2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_31760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48031">
        <property type="protein sequence ID" value="PHQ48031"/>
        <property type="gene ID" value="BLA24_31760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="7">
        <location>
            <begin position="37"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="307" mass="34691" checksum="323DC9FBF6D221F9" modified="2018-01-31" version="1">MTVVAGQDGPYVLSHVDVLESEAVHVFREVAGEFERPVMLFSGGKDSIVMLHLALKAFAPAAVPFALLHVDTGHNFPEVLAYRDRVVAEHGLRLHVASVQEFIDDGRLRERGDGTRNPLQTVPLLEAIGRHRFDAVFGGGRRDEEKARAKERVFSLRDEFGGWDPRRQRPELWQLYNGRHAPGEHVRVFPLSNFTELDVWQYIAREKIELPSIYFAHEREVFAREGMWLAPGGWGGPREGERVERRLVRYRTVGDMSCTGAVDSDAVTIEAVIAEITASRLTERGATRADDKLSEAAMEDRKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA07</accession>
    <name>A0A2G1XA07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31915</name>
        <name evidence="3" type="ORF">CYQ11_24970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48058">
        <property type="protein sequence ID" value="PHQ48058"/>
        <property type="gene ID" value="BLA24_31915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15684">
        <property type="protein sequence ID" value="PPT15684"/>
        <property type="gene ID" value="CYQ11_24970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="424" mass="44191" checksum="844B47312E2BF4B2" modified="2018-01-31" version="1">MKTSTTPAQPATGGKYRQFLPLVQTATLIEWTGTGLFLAVSTIYFVKVAHLSTASVGTGLTIGGAVAIAVSVPLARLAGRLGPKPLLIGVMLLRALATVGYLWVDGWWSFLLVVSAIAVTEQSSPPLVQSYVGARTPEDLRARVMAVQRTVVNLGISLGGLIAGAALGAGDADAFRPLLIGGAVAYLAVAAVFATAPREEGGAVAEGTSVAELLGDRRLLGFTAYNALVSLWMPVLNVAFPLWLVTATDVPERYVGVLYAVNTVLCIALQYPLNRCYRTTRRAWLSYAGAAVLLGGGALAFAAAPRFGWQGALVVLGGAVVLLTFAELLQVGASWTLSFDLAPQEARSAYLVLFNTSRTIANRVAGPVLMTGVVLALGTAGWMAFAGVMLLGALVPFVMLRRIPTAPATAPDTPASRPKARTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC9</accession>
    <name>A0A2G1XAC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32725</name>
        <name evidence="4" type="ORF">CYQ11_25775</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48188">
        <property type="protein sequence ID" value="PHQ48188"/>
        <property type="gene ID" value="BLA24_32725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15814">
        <property type="protein sequence ID" value="PPT15814"/>
        <property type="gene ID" value="CYQ11_25775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="21111" checksum="7D24F02EF5D7D92B" modified="2018-01-31" version="1">MARTKEFDPDAALQSALELFWERGYEATSMADLVERLGIARASLYGTFGSKRELYLKALERYREQHGPRAVEELSQPGPALPAVRALVRRFADEAACDVLGRGCFVTNTAVELGVRDSGSARRVEESWNSLETALTSALMRARAQGELPPGRDPVALARMLLVLLQGLRVVGKVTPDSGRLRDAADQALTLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAI8</accession>
    <name>A0A2G1XAI8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethylallyltranstransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_33060</name>
        <name evidence="4" type="ORF">CYQ11_26110</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48246">
        <property type="protein sequence ID" value="PHQ48246"/>
        <property type="gene ID" value="BLA24_33060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15873">
        <property type="protein sequence ID" value="PPT15873"/>
        <property type="gene ID" value="CYQ11_26110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="379" mass="40171" checksum="8337274002D9F391" modified="2018-01-31" version="1">MNQRAIKARVPHSGARVSTTTRGETVTSAIPAVDTAGVQALLERGRTLATPVLRAAVDRLAAPMDTVAAYHFGWIDAEGRPAHGDQGKAVRPALALLSAEAAGAPAEVGVPGAVAVELVHNFSLLHDDLMDGDEQRRHRDTVWKAYGPAQAILVGDALFALANEVLLELGTVEAGRATRRLTTATRKLIDGQAQDISYEHRERVTVAECLEMEGNKTGALLACAVSIGAVLGGADERTADTLEAYGYHLGLAFQAVDDLLGIWGDPEATGKQTWSDLRQRKKSLPVVAALAAGGSASERLAGMLAADAKLTDAQLADFSEEEFAHRAALIEEAGGREWTSQEARRQHATAIEALSAVDMPAEVRAQLTALADFVVVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB20</accession>
    <name>A0A2G1XB20_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_29050</name>
        <name evidence="6" type="ORF">CYQ11_06425</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48428">
        <property type="protein sequence ID" value="PHQ48428"/>
        <property type="gene ID" value="BLA24_29050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12576">
        <property type="protein sequence ID" value="PPT12576"/>
        <property type="gene ID" value="CYQ11_06425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="457" mass="48831" checksum="FA6E61A7E4EDB5C1" modified="2018-01-31" version="1">MRSSGRNSGSGNRDDRGGRAGSPRPGSGGGRAGGGRSGGGRPESGGRSGGGYGGGRSEGGRSGGGRPESGGRSGGGRSGGGGYGGGRSEGGRYDGGRSGDRRDDRRDDRQQERPRRPRPEERRYDVGPDAERTRNGPTSGRTGGPSGARGAAARGGAKGGPRKSSTAGAGGRSSGPARGHGYAPARPRELDAKIEERNRERHNKPQVKTPKTFPGAEQEGERLQKVLARAGMGSRRACEELIEMARVEVNGEIVTEQGLRVDPEKDEIKVDGLTVATQSYLFFALNKPAGVVSTMEDPDGRQCLGDYVTNRETRLFHVGRLDTETEGIILLTNHGELAHRLTHPRYGVQKTYLAAITGPLPRDIGKQLKSGIELEDGWARADNFRVIQQTGKNYLVEVTLHEGRKHIVRRMLAEAGFPVEKLVRTSFGPIALGDQKSGWLRRLTNTEVGMLMREVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB23</accession>
    <name>A0A2G1XB23_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28970</name>
        <name evidence="2" type="ORF">CYQ11_06505</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48416">
        <property type="protein sequence ID" value="PHQ48416"/>
        <property type="gene ID" value="BLA24_28970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12588">
        <property type="protein sequence ID" value="PPT12588"/>
        <property type="gene ID" value="CYQ11_06505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="12573" checksum="AE58898E3DFA46B1" modified="2018-01-31" version="1">MATIEECLDALDRLAENLSGASAELRGAAALDRSLSCHVTDLDATFTGHLRDGHLKEVRTLEGAPEQRAEIALEMTSEDLVALVDGRLHFARAWASGRVRVKAPLRDLLRLRSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBA4</accession>
    <name>A0A2G1XBA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29405</name>
        <name evidence="3" type="ORF">CYQ11_06070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48481">
        <property type="protein sequence ID" value="PHQ48481"/>
        <property type="gene ID" value="BLA24_29405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12521">
        <property type="protein sequence ID" value="PPT12521"/>
        <property type="gene ID" value="CYQ11_06070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="31681" checksum="97F59F7054764B66" modified="2018-01-31" version="1">MKAVSYRAYGGPEVLEYGELPKPKVGPDSVLIRVRAAAVNPVDWKAQAGYLDPMLDAVFPVVPGWDVSGVVVALGADTPEFQVGDEVIGYVRKDVLSGGTFAEYVAAPVRTLARKPAGLTFEQAAGLPLAGLTAYQSLKAAGAGEGDTVLVHAAAGGVGTFAVQLARHLGARVIGTASERNHDFLRSLGAEPVVYGEGLAERVRALAPEGVDVVLDLVGGGVVHTSPEVSAEGARLVSIADGDVAALGGRLLWVRPDAEDLTALAHLAEQGVLSVEVAEVFPLEKTADAQRLSAGGHTRGKIVVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBP2</accession>
    <name>A0A2G1XBP2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Mycothiol maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_04055</name>
        <name evidence="5" type="ORF">BLA24_04075</name>
        <name evidence="3" type="ORF">BLA24_28310</name>
        <name evidence="6" type="ORF">CYQ11_07160</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000061">
        <property type="protein sequence ID" value="PHQ53042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000061">
        <property type="protein sequence ID" value="PHQ53045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48625">
        <property type="protein sequence ID" value="PHQ48625"/>
        <property type="gene ID" value="BLA24_28310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53042">
        <property type="protein sequence ID" value="PHQ53042"/>
        <property type="gene ID" value="BLA24_04055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53045">
        <property type="protein sequence ID" value="PHQ53045"/>
        <property type="gene ID" value="BLA24_04075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12695">
        <property type="protein sequence ID" value="PPT12695"/>
        <property type="gene ID" value="CYQ11_07160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="147"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="228" mass="24320" checksum="88364614FA209128" modified="2018-01-31" version="1">MIDHVHDLNAVREATDRLLSAVGELDNAAVAEASRLPGWSRGHVLAHLARNADALGNVLEGRPMYPSAEARDTDIERGAPRPLETHLADLRDTAARFLATAAAPADWNRTVTLRNGVTDSASRVPFRRLVEVELHHVDLGIGYELEDLAAEFTHREIDFLAQRFSGHPGLPSLRLTAPDGGQWHTGAGEGTALTVTGPAPDLMGWLAGRRDGAALEAGGAPLPALPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBQ3</accession>
    <name>A0A2G1XBQ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_28635</name>
        <name evidence="8" type="ORF">CYQ11_06830</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48677">
        <property type="protein sequence ID" value="PHQ48677"/>
        <property type="gene ID" value="BLA24_28635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12642">
        <property type="protein sequence ID" value="PPT12642"/>
        <property type="gene ID" value="CYQ11_06830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="298" mass="31594" checksum="667A46C42F535208" modified="2018-01-31" version="1">MQFDDDADLDTSQVQDERGGGIPGGGLTIGGGLVGLLALLAGLFFGIGPRELGLSSGEPGSGPAATTDAQVSRTCRTGKDANTRQDCRTVAVVNSAQSFWSQELPRRGGTYTPAPTVFFTGQVRTGCGAATSAVGPFYCPADRKVYLDLGFFDELKTKFGASGGPFAQAYVVAHEYGHHVQDLTGVLGRAQDRRTGAGSNAVRVELQADCYAGVWARHATTTPERSTGRPLVERLTPADVDDGLNAAAAVGDDRIQERFQGRVTPESWTHGSAAQRRQWFTTGYSTGDVARCDTFHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC03</accession>
    <name>A0A2G1XC03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28700</name>
        <name evidence="3" type="ORF">CYQ11_06765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48689">
        <property type="protein sequence ID" value="PHQ48689"/>
        <property type="gene ID" value="BLA24_28700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12630">
        <property type="protein sequence ID" value="PPT12630"/>
        <property type="gene ID" value="CYQ11_06765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="244"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="332" mass="36059" checksum="5210F69926CF1285" modified="2018-01-31" version="1">MLEDRTAAASPSPWPAAYPEGYAVVDVETTGLARDDRIVSAAVYQLDARGRVEDQWYTLVNPERDPGPVWIHGLTTDVLSGAPLFPEIAEEFARRLQGRVLVAHNAAFDWSMIAREYARAKAAAPVRQRLCTIALSKELGLPLPNHKLESLAAHYGVVQQRAHHALDDARVLAEAFRPSLQLAAEAGLRLPLLACQPLTEWSDGPSAATRSAKIGYQPSYRSGTWRPSRKRPACPYPNPGRYKSGEQLIQGMRVAFSGDTSVDRELLEDRAVEAGLHVATSVSRLTSLLVTNDPDSPTSKVVKARSFATPVVDEAAFIQLLSHVTPAGGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCA6</accession>
    <name>A0A2G1XCA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27955</name>
        <name evidence="3" type="ORF">CYQ11_17685</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48894">
        <property type="protein sequence ID" value="PHQ48894"/>
        <property type="gene ID" value="BLA24_27955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14458">
        <property type="protein sequence ID" value="PPT14458"/>
        <property type="gene ID" value="CYQ11_17685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304773" evidence="1">
        <location>
            <begin position="20"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="417" mass="44734" checksum="65E9CF234461CAEA" modified="2018-01-31" version="1">MTAAGAATAALAPALTACGAETPGGDTKLKLVAADYGDNAANSSKKYWSSLAKAFESKNKGIKVDVQVYSWTEVDKKVADMVAAGKAPDLAQIGAYADFAAAGKLYSADQLLSIPTQADFISGIARAGEVHRVQYGLPFVSSTRLLFYNKKLFAKAGVAKAPESWDELQAAAVKLKAAGVQIPFGLPLGPEEAPAEMMMWILSAGGGYTDKNSTYTIDSEANVKAFKWLRDELVGKGLVGPGDPARTNRQDVFDAFTRGEVGMLNGHPTLMQQAKAKRIDFDTAPLPGYAGKAKATMGVADWMMAFRQNGHREQIGKFLDFVYSKDNVLSFCTDYRLLPVTTAASEAMRAERANADLWPFLGQLTNAEFYPADKTSWAKVSKTVKEKIGMAVRPGGDPESILSEIQREATATENTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCE5</accession>
    <name>A0A2G1XCE5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27865</name>
        <name evidence="4" type="ORF">CYQ11_17775</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48880">
        <property type="protein sequence ID" value="PHQ48880"/>
        <property type="gene ID" value="BLA24_27865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14473">
        <property type="protein sequence ID" value="PPT14473"/>
        <property type="gene ID" value="CYQ11_17775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="54"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="224" mass="24536" checksum="67625831929D011F" modified="2018-01-31" version="1">MTDTTAWDTYARRKPGGRREKNAKGETTWFNWTQYPDHGPGIDVLGEAEKAALLELGCGAGGNLAHAATLGHRAVGVDVSPVQLKAARERWGDLPGLELHQRGALDFMGETAERFDAVYSVFGAVWFTDPRQMLPAVRQVLKPGGVLAFSQRPPVEGCYGCQASYINQADDPNPLVVKRWDYTTDMWTGLLKEHGFRHALANEIPPPEGWKTGTLLVRALVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCE6</accession>
    <name>A0A2G1XCE6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27785</name>
        <name evidence="2" type="ORF">CYQ11_17855</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48865">
        <property type="protein sequence ID" value="PHQ48865"/>
        <property type="gene ID" value="BLA24_27785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14488">
        <property type="protein sequence ID" value="PPT14488"/>
        <property type="gene ID" value="CYQ11_17855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="171" mass="19956" checksum="935A782EA5D5D163" modified="2018-01-31" version="1">MKPPAREPLSQAQRTAIHLEVRDHYHSEDPDFLAWREGRRTFTPDNRADWWEGWHDAVHTAVSRGVAVRRARVVSEPLSEYVRWEHAYAVTNVAAGEQVRWLPRRHAKDLAVPAVDFWVFDGELVLFHHFSGDGVLMEREYVTDDELAAWCTEAFEAVWKRATPHEEYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCI9</accession>
    <name>A0A2G1XCI9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27425</name>
        <name evidence="5" type="ORF">CYQ11_18220</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48928">
        <property type="protein sequence ID" value="PHQ48928"/>
        <property type="gene ID" value="BLA24_27425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16644">
        <property type="protein sequence ID" value="PPT16644"/>
        <property type="gene ID" value="CYQ11_18220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="124" mass="13491" checksum="6C0F76E621B16276" modified="2018-01-31" version="1">MTLKVLEHEQGDWAVLQVCGEMDLVTSPSVRQHVHDAVADGRRSLVLDLGEVRFCDSSGVGVLIAARRLMRSCQGRLRLILPERGAVEGSHVNRVLGALGVRRLFDVYPDLDSATAESTDPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCS8</accession>
    <name>A0A2G1XCS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2469 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Protein often found in actinomycetes clustered with signal peptidase and/or RNaseHII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23270</name>
        <name evidence="2" type="ORF">CYQ11_22805</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_071965846.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49020">
        <property type="protein sequence ID" value="PHQ49020"/>
        <property type="gene ID" value="BLA24_23270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15334">
        <property type="protein sequence ID" value="PPT15334"/>
        <property type="gene ID" value="CYQ11_22805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="102" mass="12335" checksum="A480D73EAEA9370E" modified="2018-01-31" version="1">MSAEDLEKYETEMELKLYREYRDVVGLFKYVIETERRFYLTNDYEMQVHSVQGEVFFEVSMADAWVWDMYRPARFVKQVRVLTFKDVNIEELNKSDLDLPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCX4</accession>
    <name>A0A2G1XCX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23805</name>
        <name evidence="2" type="ORF">CYQ11_22265</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49107">
        <property type="protein sequence ID" value="PHQ49107"/>
        <property type="gene ID" value="BLA24_23805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15245">
        <property type="protein sequence ID" value="PPT15245"/>
        <property type="gene ID" value="CYQ11_22265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="24764" checksum="E60276E2743E9C2D" modified="2018-01-31" version="1">MATHVITGSGSGIGEAVAERLHARGDELWLVARDAGRAKELAGRFPGARTLVADLENPDRLSWALGHQTLPDRVDSLLHVAGVADLGPVGELTPKTWNRTLAVNLVAPAELTRLLLPQLRVSNGHVVFVNSGAGLRANAEWGAYAASKHGLKALADSLRAEEHTNGVRVTSVYPGRVATPMQAKVHQHERKDYEPGKWIDPQSVAATVLLAVDLPRDAEIHDLSVRPGHSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF6</accession>
    <name>A0A2G1XDF6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endoglycoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_24680</name>
        <name evidence="6" type="ORF">CYQ11_21390</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49260">
        <property type="protein sequence ID" value="PHQ49260"/>
        <property type="gene ID" value="BLA24_24680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15088">
        <property type="protein sequence ID" value="PPT15088"/>
        <property type="gene ID" value="CYQ11_21390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304599" evidence="3">
        <location>
            <begin position="28"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="61"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="461" mass="52167" checksum="4173B8F82C90F600" modified="2018-01-31" version="1">MPKRRLRKAAFLAVTAVLALLAPTAHARTDPGIPRLTDEHGRALTLRGWNLADKDHQGERALEDITERSVRDLSAKGFNFARLAVFWDDLEPRPGHYSERYLRKVERVLDWARLHHVRVVIDAHQDVYGPAFGGHRGIPAWATRTDGLPYRTHPDDWFAEYFEPAVQAAFQHLYEDEDLRRAQTRMWRVLAERLARHPAVFGYDLINEPMGRMRPGEDMFEAARRIEATQITPMYNRIARAIREVDRRHWLFVEPTPAAGEGRPTGLGRVEDPKVVYAPHFYNAAMEAGRDYDPASGWLRTYEAAIVHYPRAHHLPVVVGEWGPLDSSLPNMGRFYEEALASLSRYASGWAGWQWCYGGGYCALDQDGRYRPNKQRTARPFASAVAGTTTYESGERETYRLEYVPRPAGVTEVTLPPSPTGWRVRVTGGARADVTEVGPDTRRTIHVKALKGNPVTVVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDV0</accession>
    <name>A0A2G1XDV0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_25515</name>
        <name evidence="9" type="ORF">CYQ11_20560</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49406">
        <property type="protein sequence ID" value="PHQ49406"/>
        <property type="gene ID" value="BLA24_25515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14944">
        <property type="protein sequence ID" value="PPT14944"/>
        <property type="gene ID" value="CYQ11_20560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="122"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="324" mass="33525" checksum="DAAA178CB857F960" modified="2018-01-31" version="1">MPEPDPYDAKDTITPAGGGAMSLATGDAETLEGGPVPGGPASGKARSLWTDAWHDLRRNPVFVVSALVIVFLALIAVWPSLIASGNPLQCDLAKAQEGPQPGHPFGFDTQGCDVYTRTVYGARASITVGVCATAGAALLGSVLGGLAGFFGGWWDALLSRLADVFFGIPIILGGLVFLSVVTGGSVWPVVGFIVLLGWPQLSRLARGAVVGARQHDYVQAARALGAGNGRLLLRHIAPNAVAPVIVVATIALGTYIALEATLSFIGVGLKPPTVSWGIDISNASNQIRNAPHMLLWPAGALSITVLAFIMLGDAVRDALDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDW5</accession>
    <name>A0A2G1XDW5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate reductase/succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_25640</name>
        <name evidence="6" type="ORF">CYQ11_20430</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49427">
        <property type="protein sequence ID" value="PHQ49427"/>
        <property type="gene ID" value="BLA24_25640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14923">
        <property type="protein sequence ID" value="PPT14923"/>
        <property type="gene ID" value="CYQ11_20430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="4">
        <location>
            <begin position="500"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="651" mass="71406" checksum="4B1AC8A3D1418074" modified="2018-01-31" version="1">MTRVDRQSWDVVVVGAGGAGLRAAIEAREQGLRCAVICKSLFGKAHTVMAEGGIAASMANVNGNDNWQVHFRDTMRGGKFLNNWRMAELHAQEAPDRVWELETWGAVFDRTVDGRISQRNFGGHEYPRLAHVGDRTGLELIRTLQQKIVSLQQEDHRAYGDYEARLKVFQECTVTRVLREDGPKGRRVSGVFGYERESGRFFVIEAPAVVLATGGIGKSFKVTSNSWEYTGDGHALALLAGARLVNMEFVQFHPTGMVWPPSVKGILVTESVRGDGGVLRNSDGKRFMFDYVPDVFKEKYAESEAEGDRWYTDPDHNRRPPELLPRDEVARAINAEVKAGRGSPHGGVFLDVSTRMPAEAIKRKLPSMHHQFKELADVDITAEPMEVGPTCHYVMGGVEVDPDTAAACGVPGLFAAGEVAGGMHGSNRLGGNSLSDLLVFGRRAGLYAAKYAAAFATGATPAVSEADVELAAAEALRPFGAEGGDPSVSHGPAENPYTLHQELQQSMSDLVGIIRRAGEMEEALHRLAGLRARARRAGVEGHRQFNPGWHLALDLRNMLLVSECVARAALERTESRGGHTRDDHPGMDRRWRRVNLVCRLADESTGPAVTDSALGLIRLERRETPAIREDLLALFEKEELAKYLTDEELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE63</accession>
    <name>A0A2G1XE63_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26155</name>
        <name evidence="4" type="ORF">CYQ11_19485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49518">
        <property type="protein sequence ID" value="PHQ49518"/>
        <property type="gene ID" value="BLA24_26155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14762">
        <property type="protein sequence ID" value="PPT14762"/>
        <property type="gene ID" value="CYQ11_19485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758432" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="390"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="505" mass="53944" checksum="C6993B5E4C5F9986" modified="2018-01-31" version="1">MTRRPTLRCALASVAALATAWGGLAVTSPTAHADPRTTTATPLSPELERIRAAEAVKLYGDAAERPLGQRKTSLLSLGDSEISGEGVGRYEPGTAGPDNWCHRSPDAAIHRTGIPADVTYNVACSGAATANIRIGGSKQYADELVQSDNLAVKARNTRVKMVLLVAGANDDLQFGPVMTDCVERYVLLQGPCEPKYAPGWQGRVDALVPKVEQTVRDLRRTMTDAGYADGDYKLVVMGYPSPIGPDFKDNPRFPGKIPGGCVGHTSDAAWGRNYAVPAFERGMRKVARDTGALYLDNSRLFHGHEVCMEDTWARGLYIDLSNPFPPDANSVRQSFHPNDRGHGAFASCLTQLYRSGWREGGCADPASTGTPVLVEGAWDDAYRPLKSEATGTCVDAYGAASGNGTAVGGWDCTGNRNQQWWYDGERGSLHSALSHDRCVDVPGGKYAAGTAVALWNCHGGANQRFTRSGGTLRPAAAQDLCLTLAGAKEPLRLQRCDGSGSQRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE6</accession>
    <name>A0A2G1XEE6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26670</name>
        <name evidence="3" type="ORF">CYQ11_18965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49607">
        <property type="protein sequence ID" value="PHQ49607"/>
        <property type="gene ID" value="BLA24_26670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14673">
        <property type="protein sequence ID" value="PPT14673"/>
        <property type="gene ID" value="CYQ11_18965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="28334" checksum="9E3FB14CFF4E0A8B" modified="2018-01-31" version="1">MVQQALPQRDPEGPAGTSSTPVAAPRLGRPLGAGHAGKAVHGVALLLPGGRPVGLRGPTALTLAAQRPLARRLTRAGGAEGLAIHLVRYRHRGWNGSSADPVRDARWAADEMVRRYGDVPVCLIGTGMGARAALRAAGHDAVAAVLAIAPWLPEPEAVLDPDPVRQLAGRRVLIVHGTNDERTDPDLSYRLAERAKKTNRDVCRFEVHSDGHGLKQHRSEVLALAADFVRGTLFGHPYARPLADALAAPPPLGLRMPLASGFGETLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI0</accession>
    <name>A0A2G1XEI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26505</name>
        <name evidence="5" type="ORF">CYQ11_19130</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49579">
        <property type="protein sequence ID" value="PHQ49579"/>
        <property type="gene ID" value="BLA24_26505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14702">
        <property type="protein sequence ID" value="PPT14702"/>
        <property type="gene ID" value="CYQ11_19130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304655" evidence="3">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="135" mass="13093" checksum="15B9826BCA45A7A5" modified="2018-01-31" version="1">MTARPLLTAVAAGTLLSAVWFVPSANATAEQPVNRPPAASASPRPAPGTTGPGSAVGNANTTNAKSDMTAEANAQTNVPANAKGEAASADLALAATGGVDTTPYVFGGIALLAAGGALVTGAARRSRTALRRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XER1</accession>
    <name>A0A2G1XER1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24100</name>
        <name evidence="3" type="ORF">CYQ11_21975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49713">
        <property type="protein sequence ID" value="PHQ49713"/>
        <property type="gene ID" value="BLA24_24100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16713">
        <property type="protein sequence ID" value="PPT16713"/>
        <property type="gene ID" value="CYQ11_21975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14606">
        <property type="entry name" value="Lipase_GDSL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="173"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="382" mass="40509" checksum="B6E681BEFBB24C0B" modified="2018-01-31" version="1">MTDWITTPVDARIVRGALELERTPHGVLPHRLPARARKQCPDESLALAEAKPSGVRLVFRTRATVVELDVLPTKTVYKGAPAQDGVYDLLVDGRLAGQTSATGGNVVTVDMVTQAAVTTPGPVGTARFAGMPGGVKDVEIWLPHGEITELVALRTDAPVEAVPDGGRRVWLHHGSSISHGSAAANPTAIWPAVAAARGGVELVNLGFGGNALLDPFTARAMRDTPADLISVKIGINLVNTDLMRLRAFAPAVHGFLDTIRDGHPTTPLLVVSPVLCPVQEDTPGPLAPDFDGPRLRFRATGDPSDPSRLTLTVIRDQLSRITAQRAAEDPNLHYLDGLSLYGEKDFAELPLPDGLHPDSAGHRRIGENFAELAFGDGGPFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEU3</accession>
    <name>A0A2G1XEU3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26040</name>
        <name evidence="2" type="ORF">CYQ11_20025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49742">
        <property type="protein sequence ID" value="PHQ49742"/>
        <property type="gene ID" value="BLA24_26040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16684">
        <property type="protein sequence ID" value="PPT16684"/>
        <property type="gene ID" value="CYQ11_20025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="17281" checksum="541DAB15ADA53D92" modified="2018-01-31" version="1">MEARDAYSKTHSTFVDWKAGRQIDPAERWSAWHSIVSEAVSRGVEVRRARIVSTPVSEYIRFEHEVTEGLNIAAGEQVRWLPRRNASDLLVPGNDFWLFDSRLLYLNHFDGEGEPTEPEITEDPEIAKLCESAFDAIWRRAIPHAEFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEZ1</accession>
    <name>A0A2G1XEZ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19295</name>
        <name evidence="3" type="ORF">CYQ11_11505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49798">
        <property type="protein sequence ID" value="PHQ49798"/>
        <property type="gene ID" value="BLA24_19295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13426">
        <property type="protein sequence ID" value="PPT13426"/>
        <property type="gene ID" value="CYQ11_11505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="42472" checksum="F7B2559D9B15EF81" modified="2018-01-31" version="1">MTPPAGHPAGPRSLFLVGIDVDSMGGSQRVLHTLAQGFAERGHDVELIGIRPSPEPHSYTADPAYRHTTLYPTPATPVPEAASLAERFGPARLREARARRAQRGRARGLLARRLAAVPRGRRAHLVVGSPWAAVWLEPVPRPPHLKAIGQYHESFHQACHSVNLQLILRHYPALDKALFLSEADAAEFRRRRLPNAGAMPNPVPFSPSAAAPLDTRRVGAVGRLDHVKRLDRLIDAFATAAARHPGWELHLFGDGPEEAGLRERAARLGVGDRVRFRGSVRDMAAAYRELSVVALTSECEGRPMALAEASAAGVPSVAFDLSGGVRELVGHGRTGTLVPYGDTAAFAVALEELMGDPALRERYGRAARTHVAPLALPAVLDRWEALFEETDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF75</accession>
    <name>A0A2G1XF75_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19635</name>
        <name evidence="4" type="ORF">CYQ11_11160</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49855">
        <property type="protein sequence ID" value="PHQ49855"/>
        <property type="gene ID" value="BLA24_19635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13369">
        <property type="protein sequence ID" value="PPT13369"/>
        <property type="gene ID" value="CYQ11_11160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="9050" checksum="D4FB22031037166F" modified="2018-01-31" version="1">MPRPTPAQIAYGSATVVISTVALLLLSPTVSGGTAAVVALAALALGLAVAFAVPRRQARAAARPAGRPATPARAAAPVGRAATHAVGEHSVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD4</accession>
    <name>A0A2G1XFD4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20010</name>
        <name evidence="9" type="ORF">CYQ11_10780</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49915">
        <property type="protein sequence ID" value="PHQ49915"/>
        <property type="gene ID" value="BLA24_20010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13310">
        <property type="protein sequence ID" value="PPT13310"/>
        <property type="gene ID" value="CYQ11_10780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="47"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="35745" checksum="C447399DD6F2FF76" modified="2018-01-31" version="1">MYRTAPLGKRPRWWTELPLIAVVYGLYTAGRLLVRGDVQSAVDHGLSILDFEKTFRINFEHPLNRLFTDHPLLGIPADFAYASLHYLLTPALLVWLFRRRPEHYRKLRTWLLASTLIGLIGFTLLPTCPPRLLDEGVGFIDTMRQYSEYGWWGGDASAPRGLGGMTNQYAAMPSLHVGWALWCGAVLWRHTRSGWGKALGVLYPLLITLVVMGTANHYFLDAAAGAAVMGAGYLLAGPVLRLTDHVRSRFTHPVAGKTTEADAAVSGGCETSAGTALPRTTAPGSPAGAGRPGAPETLREADASDHHIPRQQARGEAGEGSPDSAATAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFM6</accession>
    <name>A0A2G1XFM6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_20670</name>
        <name evidence="10" type="ORF">CYQ11_10110</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50027">
        <property type="protein sequence ID" value="PHQ50027"/>
        <property type="gene ID" value="BLA24_20670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13195">
        <property type="protein sequence ID" value="PPT13195"/>
        <property type="gene ID" value="CYQ11_10110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="27"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="468" mass="49638" checksum="DBABDA4B8570479F" modified="2018-01-31" version="1">MHDAQSAAEPLAGGEKEPLAAGLKQRHLTMLGLGGVIGAGLFVGSGAGIAVAGPGIIVSYLIAGALAMLVMRMLGELSAAMPASGAFSVHAERALGRWAGFTVGWLYWFLLVVVLAVEATGAAQIANGWLPSVPQWAWVLVFMVVFTSANLAAVKNFGEFEFWFAALKVGAIVLFLGLSLLAIFGLLPDTEAVGMTNLTGQGGFLPNGWSGVISGVLAVVFAFGGLEVVTIAAAESDDPARAVGRAVRSAVWRILFFYVGSMLVIVTLLPWSSMQAGKSPYVAVLDHVGVPGAGQIMNIVVFVALLSALNANLYGSSRMVFSLAERGEAPRGLLKVSGGGVPRRAVLASVAFGFASVILNLEWPDSIFRYLLNAVGAVLLFVWGLIAASQLRLRRRIEREMPERLTLRMWCFPYLTWAALAGMGGVLVLMLTDRDARPQLLWSAAATGAVLLVAVLREFRDRRTRQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFT6</accession>
    <name>A0A2G1XFT6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_21060</name>
        <name evidence="10" type="ORF">CYQ11_09725</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50087">
        <property type="protein sequence ID" value="PHQ50087"/>
        <property type="gene ID" value="BLA24_21060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13133">
        <property type="protein sequence ID" value="PPT13133"/>
        <property type="gene ID" value="CYQ11_09725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="8">
        <location>
            <begin position="589"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="860" mass="86481" checksum="118D3B81534566E1" modified="2018-01-31" version="1">MTGTAGAPGGAADAGAGPGEHRVGVPDLRLAALALAVWGAAAVALTADAGMVAAGCAGAVLAAGGLLVAVRRSGAGAARTAVAAVLLCASAGAAVGSVAGADSRRGPLPQLARSYGTVEIEAVVTAEARAARPRVRGSHRTAPAVLVEAEATRVLGAGDAGTGPAGTGRTRGTGPATAVRTPVLLIAPRSWAGLLPSTRLRVEGRLAPPSREGDRIAAVLRVGDQGPPQVVAPPSATQRAAARLRAGLRSATDGLSPDVRALLPGLVVGDTSRVPPELEEDFRATGLTHLLAVSGGNLAVLLSLLVGPSHLASRAERRGLAARLGIPLRLTAALGGGLALGFVVLCRPDPSVLRAAACGLITLLAIGTGRRRSLLPALAAAVLLLVLHDPWLARSYGFALSVLATGALLTLAPRWSAALRRRGVPPRIAEALAAAGAAQAVCAPVIVVLAARVSLVAVPCNLLAEPAVAPATVLGFAALALAPLAPPLAQCCAWLAGWPVAWTAGVARAGAGLPGAELSWPGGWGGALLLAALTVPAAWVARRMPRRPWARAGCAVLLLLAVLRPVPLTRGVTGWPPPGWRLVACDVGQGDALALAAGDGAAVVVDAGPEPRAVDGCLRGLGVDTVPLLVLSHFHADHVDGLPGVLRGRSVGLIETSPFGRPPAQAAFVRREARRAHVPVVEAVAGERRHLGGLSWEVLWPPPPGLSAVAEDGPNDASIALLVRTAGLTLLLLGDLEPPAQQELWRSHPGLPPVDVLKVAHHGSAHQDPELLHGLRPRLAVISAGAGNPYGHPAARTVTALRSQGAAVLRTDTDGPVAVTGAATAVTARRTGRRGTGDVGRVLRPDVGPGPDVTGVSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFY9</accession>
    <name>A0A2G1XFY9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21480</name>
        <name evidence="4" type="ORF">CYQ11_09305</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50153">
        <property type="protein sequence ID" value="PHQ50153"/>
        <property type="gene ID" value="BLA24_21480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13063">
        <property type="protein sequence ID" value="PPT13063"/>
        <property type="gene ID" value="CYQ11_09305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="333"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="421" mass="44747" checksum="67F6C821FA887480" modified="2018-01-31" version="1">MVDAHQTFVIVGGGLAGAKAAETLRSEGFTGRVILICDEREHPYERPPLSKGYLTGRDARDSVFVHKPDWYARADVELHLGQPAVHLDRAAKSVRLGDGTVVHYDKLLLATGAEPRRLDIPGTGLAGVHHLRRLAHAERLRGVLSSLGRDNGHLVIAGAGWIGLEVAAAARGYGAEVTVVEPEPTPLHTVLGPELGQLFTDLHSEHGVRFHFGARLTEIAGHDGMVLAARTDDGEEHPAHAVLAAIGAASRTALAEAAGLALVDRADGGGVAVDASLRTSDPDVYAAGDVAAAEHPWLGTRLRVEHWANALNEGPAAARAMLGAEVSYDRVPYFFSDQYDVGMEYSGYAPPGSYDQVVCRGDVGKREFIAFWLSEGRLLAGMNVNVWDVTGPIQRLIRAGARVDPEALADPGVPLDTLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFZ8</accession>
    <name>A0A2G1XFZ8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">leuA</name>
        <name evidence="6" type="ORF">BLA24_21310</name>
        <name evidence="7" type="ORF">CYQ11_09475</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50125">
        <property type="protein sequence ID" value="PHQ50125"/>
        <property type="gene ID" value="BLA24_21310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13094">
        <property type="protein sequence ID" value="PPT13094"/>
        <property type="gene ID" value="CYQ11_09475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="589" mass="64861" checksum="BAB2C4D9EFA1310C" modified="2018-01-31" version="1">MPEISPSVGRPTPVTAATVRQRPSGMPVHRYRPYEAVAIPDRTWPDNRITTAPRWLSTDLRDGNQALIDPMSPARKREMFDLLVRMGYKEIEVGFPSSGATDFEFVRSIIEEGAIPEDVTISVLTQAREELIERTVESLRGAHRATVHLYNATAPVFRRVVFRGSREQVKQIAVDGTRLVVEYADKILGDGTVFGYQYSPEIFTDTELDFALEVCEGVMDVWQPEAGREIILNLPATVERSTPSTHADRFEWMSRHLSRREHICLSVHPHNDRGTAVAAAELAIMAGADRIEGCLFGQGERTGNVDLVTLGMNLFSQGVDPQIDFSQIDEVRRTAEYCNQMEVHPRHPYAGDLVYTAFSGSHQDAIKKGFEVMAADAAAAGRSVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRRMQIEFSKIIQTKTDAEGGEVTPQEIWSVFQDEYLPTPDNAWGRIALRGTHTSTTSEGRDALTVEAVVDGRETVLTGTGNGPISAFFDALTATGVDARLLDYTEHTMSEGASAQAASYIECVIDGTVLWGIGIDANTTRASIKAVVSAVNRAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGD0</accession>
    <name>A0A2G1XGD0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22380</name>
        <name evidence="3" type="ORF">CYQ11_08405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50300">
        <property type="protein sequence ID" value="PHQ50300"/>
        <property type="gene ID" value="BLA24_22380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12913">
        <property type="protein sequence ID" value="PPT12913"/>
        <property type="gene ID" value="CYQ11_08405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304903" evidence="1">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="433" mass="45704" checksum="99114F51C97FB1F3" modified="2018-01-31" version="1">MRRGISVAAVVGVLALTATACGGGGDSGNDGSKAAEDPGSVSGTITWWDTSDATNEAPAFKKLVKDFEAKYPKIKVDYVNVPFDQAQQKFKTAASTGKGAPDVLRSDVGWTPGFAQLGYLKDLTGTPALDKSEDFLEGPLKNAAYQGKTYGVPQVTDTLGLLYNKELFQKAGLDKAPATWQEVKDAALKIKEKTGADGIGLSPDSYYSLPFLYGENSDMVDAAKKKITISSAASLKGVETAVDLVKSGAAPKPAGTDGYNALKTDFKNGKLGMLIDGPWATKEIFGGDAYKSRENLGIAPIPAGSTGTAGAPVGGHNLVLYAGSKNFDASYLFARFMTESAQQESVSNAVGVLPTRKSAYSQTVLADPVRSAFHDALAKAHPRVPIPQGGDLFTEWLQHYTKILTLKEDPKAGVDATAKAWQSALLKDYGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGE9</accession>
    <name>A0A2G1XGE9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22400</name>
        <name evidence="2" type="ORF">CYQ11_08385</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50304">
        <property type="protein sequence ID" value="PHQ50304"/>
        <property type="gene ID" value="BLA24_22400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12909">
        <property type="protein sequence ID" value="PPT12909"/>
        <property type="gene ID" value="CYQ11_08385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="28450" checksum="18E5FAFF94571F00" modified="2018-01-31" version="1">MPQQFDASTITNLRDLGGIALVGNSAVRPGLLLRSGQLDRLDPAADPSVAALGIHTVVDLRTEKERRERPDRLPEGARLIVADVLAGAFSRHRAGDAPAGGEVPARLEDVLGNPAVADEYLGGGKAEKLMCDTYRTFVTSESACQAYGLLLTTLAEPDCGPVLFHCTAGKDRTGWAATVVLLLLGADEETAGREYLAVAPAVRAAFAPLIDGFTAVGGDPEIAGAILGVRPAYLAAALEAMRWAYGSVEGYVRDGLGISDAAVDRIRARCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGG3</accession>
    <name>A0A2G1XGG3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnA</name>
        <name evidence="6" type="ORF">BLA24_22340</name>
        <name evidence="7" type="ORF">CYQ11_08445</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50295">
        <property type="protein sequence ID" value="PHQ50295"/>
        <property type="gene ID" value="BLA24_22340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12919">
        <property type="protein sequence ID" value="PPT12919"/>
        <property type="gene ID" value="CYQ11_08445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="453" mass="50678" checksum="D26B2766BA1A0B29" modified="2018-01-31" version="1">MDKQQEFVLRTLEERDIRFVRLWFTDVLGYLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVYESDMIAKPDPGTFQILPWRAEAPGTARMFCDILMPDGSPSYADPRYVLKRILAKTSDLGFTFYTHPEIEFFLLKDKPVDGTRPVPADSSGYFDHTPQNVGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNIMTFRLVMKQVALEQGVHATFMPKPFSEYPGSGMHTHLSLFEGDRNAFHESGAEYQLSKVGRSFIAGLLRHAAETSAVTNQWVNSYKRIWGGSQRTAGAGGEAPSYICWGHNNRSALIRVPMYKPGKTGSTRVEVRSIDSGANPYLTYAVLLAAGLKGIEEGYELPAGADDDVWALSDAERRAMGIEPLPQNLGEAIELMERSELVAETLGEHVFDFFLRNKKQEWEEYRSEVTAFELRKMLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGN6</accession>
    <name>A0A2G1XGN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20210</name>
        <name evidence="4" type="ORF">CYQ11_10580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50375">
        <property type="protein sequence ID" value="PHQ50375"/>
        <property type="gene ID" value="BLA24_20210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16477">
        <property type="protein sequence ID" value="PPT16477"/>
        <property type="gene ID" value="CYQ11_10580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="381" mass="42014" checksum="B9EE8E4AFC887A58" modified="2018-01-31" version="1">MRIAMNGVTGRMGRRQHLERSVLALREEGGIDLGTGTVLWPVPVLVGRDGRKLAALAAHHGIEHWTTDLDAVLADPGIDVYFDAQATTARERALRRALAAGKHVYCEKPTATTYAGALGLARLARDAGVRHGVVQDKLFLPGLRKLRRLADGGFFGRVLSVRGEFGYWVFEGDWQSAQRPSWNYRSQDGGGIAADMFPHWEYVLRELFGPVRAVQARLITHIPRRWDERGRPYEATADDAAYGIFELEGGAVAQFNSSWAVRVHRDELLELQVDGTEGSAVAGLRHCRAQHRSATPKPVWNPDLPATETFRAQWQEVPGNGDAGEGVNAFKAQWELFLRHVAVGGPWRFDLLAGARGVQLAELGRRSSAEGRRIAVPEPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT4</accession>
    <name>A0A2G1XGT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNB domain-containing ribonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Ribonuclease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22095</name>
        <name evidence="3" type="ORF">CYQ11_08690</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50425">
        <property type="protein sequence ID" value="PHQ50425"/>
        <property type="gene ID" value="BLA24_22095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16431">
        <property type="protein sequence ID" value="PPT16431"/>
        <property type="gene ID" value="CYQ11_08690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040596">
        <property type="entry name" value="RNase_II_C_S1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18614">
        <property type="entry name" value="RNase_II_C_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="52"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="488" mass="53051" checksum="956C17A3F6579185" modified="2018-01-31" version="1">MPRRPMRVTDAERAPLATALRELRARTHVPGGFPPAVLEEAERAARRPRMPAYDATDVPLFTIDPPGSTDLDQAMYLARRDAGGFRVYYAIADVGAFVAPGGALDREAHERVVTLYYPDLRVPLHPPVLGEGAASLLPDHDRPAVLWRLDLDADGNVERTDVRRAVVRSRARLDYAGVQRALDSGTAEEPLSLLREVGRLREGLERTRGGVSLNVPEQEVVRRADGRYALEYRAPLPAEGWNAQISLMTGTAAAQLMLTAGTGVLRTLPAAPESAVARLRRVARALGVTWPEAMPYAVVVRALDPRHPQHAAFLQECTALLRGAGYAAFDRDRPSELPPPAAPVHAALAAPYAHCTAPLRRLVDRYTSELCLAAVAGTAAPEWVRAALDALPAEMERGGRRAGEAERECVDLVEAALLRDRIGEVFDGYVVDVVESRPTAGRVHLYDPAVIGHVEGDGDGPPLPLGRRMRVRVIEANPGREKVWFAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT5</accession>
    <name>A0A2G1XGT5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_16470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50443">
        <property type="protein sequence ID" value="PHQ50443"/>
        <property type="gene ID" value="BLA24_16470"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="13">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="14">
        <location>
            <begin position="439"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="546"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ50443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="596" mass="62410" checksum="208E2428FB1A4BA4" modified="2018-01-31" version="1">MTGIRLPAPRPGWSVDADVVVIGSGVAGLTVALRCAAAGARVAVVTKARLDAGSTRWAQGGIAAALGDGDTPEQHLDDTLVAGAGLCSDEAVRTLVTEGPDAVRRLIATGARFDTDAAGEILLTREGGHHRNRIAHAGGDATGAEISRALVEAVRDAGIRTIEHALVLDLLKDAEGRAAGVSLHVMGEGQHDGVGAVHAGAVVLATGGMGQVFSATTNPAVSTGDGVALALRAGAEVSDLEFVQFHPTVLWLGPDAEGQQPLVSEAVRGEGAHLVDAGGHRFMVGAHELAELAPRDIVAKGIMRRMREQGAEHMYLDARHFGADMWAKRFPTILAACRTHGIDPVTEPIPVAPAAHYASGGVRTDLHGRTTVPGLYACGEVACTGVHGANRLASNSLLEGLVFAERIAADIAPGPRPGDAVTPEEPAARLIAPEARLVIQRAMTQGAGVLRSRQSLERTAAELARIREEAGDKTVEPGTEAWETTNLLLVSQVLVAAALRREETRGCHWREDHPGRDDERWRRHLVVTLGADRTLAVAATDSAAFPPVPLARPAAGDPPLPPPQGEPREHQRRPSPAPDRPVRPGDRGADGGRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGV9</accession>
    <name>A0A2G1XGV9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein BLA24_16620</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16620</name>
        <name evidence="4" type="ORF">CYQ11_16665</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50466">
        <property type="protein sequence ID" value="PHQ50466"/>
        <property type="gene ID" value="BLA24_16620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14279">
        <property type="protein sequence ID" value="PPT14279"/>
        <property type="gene ID" value="CYQ11_16665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="13001" checksum="9ADCA40D7612B8FA" modified="2018-01-31" version="1">MGIEDFGGGQHEKADVLVVTTNDVPGYRVERVIGEVFGLTVRSRHIGSQIGAGLKSLVGGELKGLTKTLVETRNQAMERLVQQAKARGANAVLMFRFDVTEAADVGTEVCAYGTAVVIAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGY0</accession>
    <name>A0A2G1XGY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20845</name>
        <name evidence="4" type="ORF">CYQ11_09935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50389">
        <property type="protein sequence ID" value="PHQ50389"/>
        <property type="gene ID" value="BLA24_20845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16463">
        <property type="protein sequence ID" value="PPT16463"/>
        <property type="gene ID" value="CYQ11_09935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="376" mass="39423" checksum="1C0454161F3F7DD4" modified="2018-01-31" version="1">MSPLPPRSVAIVLGTRPELVKLTDLVRLLGPAAHLVHTGQHYDEELSGRFLTELGLPEPTFLTGVGGRPRAVQISAALAQLDDLFTTEPPLAVVVQGDTNAALAGALAANARGIPLVHVEAGLRSHDRAMPEEHNRVLIDRLADVLCAATEDNRANLLAEGVDDARVAVTGNTVVEAVLGQLPGERERTRLLAGRGLTADGYVLATVHRPENTDAPDALRAILGELGALATAGRPVVLPLHPRTRGRIEAAGLTDLLAPLTVTAPLGYSEFLALARHAALLVSDSGGIQEECTVLGRPLVVVRRSTERPEAMAEFADLVRPGREIGEAARRRLAEGPEGLARLAALPSPFGDGLASERIVNLLVAIAAPAELATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH91</accession>
    <name>A0A2G1XH91_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_17525</name>
        <name evidence="6" type="ORF">CYQ11_15750</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50602">
        <property type="protein sequence ID" value="PHQ50602"/>
        <property type="gene ID" value="BLA24_17525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14143">
        <property type="protein sequence ID" value="PPT14143"/>
        <property type="gene ID" value="CYQ11_15750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304876" evidence="3">
        <location>
            <begin position="30"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="218" mass="23057" checksum="3B41F0D29B653FB0" modified="2018-01-31" version="1">MRTKFLGAALATAAALTLTACGGSGSASGDKPVADVSAEPRKAGAITLDSPKAKPDLVLTDTSEKKYELVKETKGRPVLLYFGYTYCPDVCSTVVSDIAAAEKKLPKEDQDKLQVVFVTTDPERDTPRRMREWLDAQGGQDIVGLTGDFATIEAAAKPLGILVEPAKKEKDGSVTVSHGAEVVGFSPKDDGGHWIFTASSTSEQYAADLPKIVKGENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHC6</accession>
    <name>A0A2G1XHC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17790</name>
        <name evidence="3" type="ORF">CYQ11_15485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50648">
        <property type="protein sequence ID" value="PHQ50648"/>
        <property type="gene ID" value="BLA24_17790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14097">
        <property type="protein sequence ID" value="PPT14097"/>
        <property type="gene ID" value="CYQ11_15485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="477" mass="50974" checksum="4566BE4D60BB2D5A" modified="2018-01-31" version="1">MTAPYEVEAPLPDGVPADGAHAAGEFGELLPATRRALLHRLATGQVEGRTPSLVGAVMRDGRMVWCAGRGEVGATAPGADTQYRIGSLTKTFVAVMVMRLRDEGLIDLDEPLSAYLDVPEGGGATIAQLLSHSSGLAAEARGPWWERTDGALRPELADLFGERAQLHTAGRVYHYSNPGYALLGALVEKLRGDNWYEALRREVLVPLGMRRTTFAPQAPHARGWAVHPWADVLLPEPAVDTGRMAPAGQLWSTAEDLCRFAAFLLDGDDRVLGAGTVEEMRAPEAEPQGEDWSGGYGLGVQLVRRQGRLLCGHTGSMPGFVAMLWVSPRDGVGSVVLGNLTSLSTAGPVAVDLVKTVAEHEPRIPEPWRPLDGADPALLELTGPWYWGAAPFALRLLAGRALDLAPLGASGRAARFRAEADGTWTGLDGYYAGESLRVVRRADGTVSHLDVGTFVFTREPYEAQGAVPGGVDTDGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHF0</accession>
    <name>A0A2G1XHF0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_17900</name>
        <name evidence="9" type="ORF">CYQ11_15375</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50668">
        <property type="protein sequence ID" value="PHQ50668"/>
        <property type="gene ID" value="BLA24_17900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14077">
        <property type="protein sequence ID" value="PPT14077"/>
        <property type="gene ID" value="CYQ11_15375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="24900" checksum="3A978B7E39F87BE3" modified="2018-01-31" version="1">MDDVTRDRANDGELLSMHLDGDPDAFGELVRRHRDRLWAVALRTLGDREEAADAVQDALVSAYRAAHTFRGQSAVTTWLHRITVNACLDRARKAASRRTSPLAETERLEQLLEPHESAAAPAERGDLHRELIQALAKLPPDQRAALVLVDMQGYPVAEAAKVLDVPTGTVKSRCARGRARLLPMLTHLRPDGRGSPPLDRERNRSQGASVPPPAGQSEADPVKGGGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHG6</accession>
    <name>A0A2G1XHG6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KH domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_17940</name>
        <name evidence="6" type="ORF">CYQ11_15335</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50676">
        <property type="protein sequence ID" value="PHQ50676"/>
        <property type="gene ID" value="BLA24_17940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14069">
        <property type="protein sequence ID" value="PPT14069"/>
        <property type="gene ID" value="CYQ11_15335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="113"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="19232" checksum="192A6BA25A19230D" modified="2018-01-31" version="1">MKESTVTDTQRQTEVAAEGTDTLTRLEQEGEIAADYLEGLLDIADLDGDIDMDVEADRASVSIISDSTSRDLQKLVGRDGEVLEALQELTRLAVNRETGDRSRLMLDIAGFRARKRQELAGLGAQAAEEAKSTGQPVKLDPMTPFERKVVHDAVAAAGLRSESEGEEPQRRVVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHT9</accession>
    <name>A0A2G1XHT9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">clpB</name>
        <name evidence="13" type="ORF">BLA24_18660</name>
        <name evidence="14" type="ORF">CYQ11_14620</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50793">
        <property type="protein sequence ID" value="PHQ50793"/>
        <property type="gene ID" value="BLA24_18660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13949">
        <property type="protein sequence ID" value="PPT13949"/>
        <property type="gene ID" value="CYQ11_14620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ50793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="879" mass="95705" checksum="B95DFF95C2577907" modified="2018-01-31" version="1">MDAELTNKSREALSAANDRAVSAGHADMTPAHLLLALLAGRDNENVMDLLAAVEADAAALRSGGERLLAGLPSAQGSTVAPPQPNRELMAALADASERARDLGDEFISTEHLLIGLAAKGGRTGELLDQQGASARKLLAAFEAARGGQRVTTADPEGTYKALEKFGTDFTAAAREGRLDPVIGRDHEIRRVVQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVPESLKNKRLVALDLGAMVAGAKYRGEFEERLKTVLAEIKASDGQIITFIDELHTVVGAGAGGDSAMDAGNMLKPMLARGELRMVGATTLDEYRERIEKDAALERRFQQVLVAEPTVEDSIAILRGLKGRYEAHHKVQIADSALVAAATLSDRYITSRFLPDKAIDLVDEAASRLRMEIDSSPVEIDELQRAVDRLKMEELALRNESDEASKERLAKLRRDLADKEEELRGLTARWEKEKQSLNRVGELKERLDELRVQAERAQRDGDFDTASKLLYGEIPGVERELEEAAQAEAAAEQEAAAKDLMVKEEVGPDDIADVVASWTGIPAGRLLEGETQKLLRMEDEIGKRLIGQAEAVRAVSDAVRRSRAGIADPDRPTGSFLFLGPTGVGKTELAKALADFLFDDERAMVRIDMSEYGEKHSVARLVGAPPGYVGYEEGGQLTEAVRRRPYSVVLLDEVEKAHHEVFDILLQVLDDGRLTDGQGRTVDFRNTILILTSNLGSVFLVDPLLKEEQKREKVLEIVRASFRPEFLNRLDDVVVFHPLGAEQLERIARIQIGHLQRRLADRRLTLEVADAALGWLATLGHEPEAEGGAAPDLTYGARPLRRLVQTAIGDQLARAILAGDVRDGDTVVVDRAPDGADGLVVTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHW8</accession>
    <name>A0A2G1XHW8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLATT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18790</name>
        <name evidence="5" type="ORF">CYQ11_14490</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50816">
        <property type="protein sequence ID" value="PHQ50816"/>
        <property type="gene ID" value="BLA24_18790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13926">
        <property type="protein sequence ID" value="PPT13926"/>
        <property type="gene ID" value="CYQ11_14490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040688">
        <property type="entry name" value="SLATT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18183">
        <property type="entry name" value="SLATT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="243" mass="26999" checksum="2B18F14496FA7470" modified="2018-01-31" version="1">MSQPEMQPEGLPREQDGKLRGDLRGRTFPLGDWGEPAERLDELYRWVEGGALNLADWYLTDRAWKRRWARALRLGTATCAVVGAALPLLELTKVLRTGSAWAFLALLGAVTCVACDRYFGLTSGWMRAVATAQAVQRRLEVLQFDWASECVREVLGPTEGTASEAAERCLSVLRRFSEDVSELVRAETADWMVEFRAGPAPLLTQSLVAWGPRGEAGGPVGRFPMPPHTRPNMPRQRPPESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHX2</accession>
    <name>A0A2G1XHX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat-shock protein HspR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18645</name>
        <name evidence="4" type="ORF">CYQ11_14635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50791">
        <property type="protein sequence ID" value="PHQ50791"/>
        <property type="gene ID" value="BLA24_18645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13951">
        <property type="protein sequence ID" value="PPT13951"/>
        <property type="gene ID" value="CYQ11_14635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="17015" checksum="B085293FD335DA7F" modified="2018-01-31" version="1">MEGVGRRRNPYELTDESPVYVISVAAQLSGLHPQTLRQYDRLGLVSPDRTAGRGRRYSARDIELLRQVQQLSQDEGINLAGIKRIIELENQVAALSARVAELQQVVEGATTAMQQAEAAVHASYRRDLVPYQDVQQASALVVWRPRRDREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHZ2</accession>
    <name>A0A2G1XHZ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_18765</name>
        <name evidence="10" type="ORF">CYQ11_14515</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50811">
        <property type="protein sequence ID" value="PHQ50811"/>
        <property type="gene ID" value="BLA24_18765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13931">
        <property type="protein sequence ID" value="PPT13931"/>
        <property type="gene ID" value="CYQ11_14515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="574" mass="59263" checksum="A04A2BE25EE120A0" modified="2018-01-31" version="1">MEGLSPEDPRTLGAYRLLGRLGAGGMGRVYLARSDRGRTVAVKLVQPELACQEEFRRRFRQEVQAARRVGGEWTAPVLDADTEADVPWVATGYIAGPSLRQVVDHDFGPLPERSVRILGAGLARALTAVHAAGIVHRDLKPSNVLITLDGPRVIDFGIARALETVTDGGLTRTGAAVGSPGFMSPEQVRGAQVTPASDVFCLGSVLAYAATGRMPFGTADSGVHALMYRIAQEEPDLDGVPAPLRPLISEFLAKDPAERPTPEQVLEQTGVEDLLGDLRTAEPWLPGGLVAQLGRHAVRLLNVEEPAGAPAPPISAAEPPTRVEPPVAARPADPPTVTTPAQPLPPQVPGPHAPYGYGSPYHHPTVVVAPAPPPRRSKTPVIVTAIVVAGLLTGGGTVYLLNRETHDTGHGAGPVPASSASARSTAPSGGTASSAGPATPAPGPPTAVGASPTPTSGGQGFEGTWQSSFGSGSRVNTRTITVSQGPAAGVTIDGSGVLDDGSSYVCTWRTTVTGGGTAGTPMRLGPSSVTRAMPTSACQPGSASELVLLPDGRMRRDFADSGTKDASLVYRKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI35</accession>
    <name>A0A2G1XI35_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19045</name>
        <name evidence="4" type="ORF">CYQ11_14235</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50851">
        <property type="protein sequence ID" value="PHQ50851"/>
        <property type="gene ID" value="BLA24_19045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13891">
        <property type="protein sequence ID" value="PPT13891"/>
        <property type="gene ID" value="CYQ11_14235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="273"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="723" mass="74208" checksum="31E8DD79E19BC0CD" modified="2018-01-31" version="1">MRWLVGWSRTSAGSGPGGLPDPEGPDDANVQPVGAQLLWGAPAPLWAVGDWRPDEVRVIQTDPTTRLAVFGRCGASDDALRAGLVAARGGALRHLSAWPGSYTAVAQVGRRLTVLGDLAGARPVFHTAWSGGTAYATAALPLADLVEAQLDVGHLAALLACPDAPEALGDSTPYTGVRRVPPGHALILRDGARDITGYEPTTSLAVAAPQRDAAQAMDGVRNALVESVRTRLAAPRHAPDYGAGTPEARDPGPVPGMGPAQRRAARGAPAPGIGADLSGGSASGTLALLAAGLPGMPGTPHGLGTAAGERLQAVTFNDLATGGGRAREAELERARALAAGPRLRHVIVAAGTEALPYAGLADGPLTDEPCPALVDAARHRHRLAAGSADHFVGHGARQVLDAHPARLTDLLMDRRRRHLLRPVSALARADGPSAHSLFVPFTVYRAARRLARTTYREGIEAAADALLRAGAGENGGPGTTGAAGAVDASLAALTWCRPGPAARWLTGEALAEVSVRLHGAAVRPPAGPLQRPGERRAAAALGRHAADHRVFEQAAEVRGQRLHAPFLDNQVVRACRALPEALRVQPGARASVLRAVLAGAGIRELPPGWGATSHASHAAAMRTGLAASLGNLLELFTAPLLADAGLIEAHVVRGALCAAAEGAALPLDGLAELVAVEVWLRRLLARRGTCWTGSAAPRQRAAAGGVIPPRAQGVPFGTAQVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ4</accession>
    <name>A0A2G1XIJ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">BLA24_14795</name>
        <name evidence="9" type="ORF">CYQ11_13275</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51045">
        <property type="protein sequence ID" value="PHQ51045"/>
        <property type="gene ID" value="BLA24_14795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13732">
        <property type="protein sequence ID" value="PPT13732"/>
        <property type="gene ID" value="CYQ11_13275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13440" checksum="C232C674360FB707" modified="2018-01-31" version="1">MAYGVKIAKGDAYKRAAKQRRHIRIRKNMSGTAERPRLVVTRSNRGITAQVIDDLKGHTLASASHLDASVRGGEGDKSAQAKKVGALVAERAKAAGVEAVVFDRGGNKYAGRIAALADAAREAGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM6</accession>
    <name>A0A2G1XIM6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_15150</name>
        <name evidence="5" type="ORF">CYQ11_12920</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51108">
        <property type="protein sequence ID" value="PHQ51108"/>
        <property type="gene ID" value="BLA24_15150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13668">
        <property type="protein sequence ID" value="PPT13668"/>
        <property type="gene ID" value="CYQ11_12920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="12"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="357" mass="37228" checksum="093B6D50D212E95A" modified="2018-01-31" version="1">MRGVIFDGKRPQVVDDLEVRGPGPGEVLVAVTAAGLCHSDLSVLDGTIPHPLPVVLGHEGVGVVEGVGPGVTHVAPGDHVALSTLANCGACADCDRGRPTMCWNSIGRPARPFSWRGERPYHFAASSVFAERTVVKAAQAVRIPDDIPAASAALLGCAVLTGVGAVLNRARVAQGDSVLVIGTGGVGLNVLQGARLAGASVVVAVDADPAKEALARTFGAKHFVDASAVPDVPSAVREILPAGVDHAFECVGDARLVRQAIDLLGRRGQAVLLGVPPAGVEASFRVSSMYLDKSILGCRYGSSRPQHDIALYARLYREGRLLLDELVTRVYPVGQFERAVEDAHNLSGARGVLSFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ42</accession>
    <name>A0A2G1XJ42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16135</name>
        <name evidence="4" type="ORF">CYQ11_11940</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51274">
        <property type="protein sequence ID" value="PHQ51274"/>
        <property type="gene ID" value="BLA24_16135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13501">
        <property type="protein sequence ID" value="PPT13501"/>
        <property type="gene ID" value="CYQ11_11940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="12069" checksum="871CB2DEC5DD1B02" modified="2018-01-31" version="1">MPLTVYVDGVPHQARQGQTVAALLLTADRPSWRTTRRGGRPRGLFCGTGVCHDCLVVVNGLPDVRACLRELREGDRIETQDGARLPARPPGADDGRTDDGRTGAGGAGDGGPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJF0</accession>
    <name>A0A2G1XJF0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4243 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15375</name>
        <name evidence="3" type="ORF">CYQ11_12700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51355">
        <property type="protein sequence ID" value="PHQ51355"/>
        <property type="gene ID" value="BLA24_15375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16521">
        <property type="protein sequence ID" value="PPT16521"/>
        <property type="gene ID" value="CYQ11_12700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="375" mass="40425" checksum="348D19DE08B15FF8" modified="2018-01-31" version="1">MPVTGYTDALHDALERLDGLGFERGADADLANHGPMGAEALAALGHTDQVAAWVEGYRTAMPHNPVPAPRFALDAGDASSWRPALGDFSRVGDWEELFRRELAEAPWAEVLTRWWPRLLPGMLAGLTHGTIRTAHAVRSLATTPAPTPAQLTELAGGLAYWAARFAHLPGQVRMSGTHDLAAAVAALPRTPHTGERRGRAAAAHRLVHPDELTGYTEALGALAPVPADRTQEMLSDLTAEFAGVYTGHPEVFAVPLIHGVTAPAAVRLVLPHLPQELHEPSLAALWHVGTTLLVAFTEHRSGEADAAREAAEAAAELPSFDELAARAAEHGDEHVIKFTEACRREHALRPDHRYPAAVLTAQQRITPRRPRASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJQ6</accession>
    <name>A0A2G1XJQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13230</name>
        <name evidence="2" type="ORF">CYQ11_00950</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51472">
        <property type="protein sequence ID" value="PHQ51472"/>
        <property type="gene ID" value="BLA24_13230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11654">
        <property type="protein sequence ID" value="PPT11654"/>
        <property type="gene ID" value="CYQ11_00950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="304" mass="33523" checksum="10633C08E7754C4B" modified="2018-01-31" version="1">MYTLYGQDATTVRGTGEISISTNATLNATNTSWDEHIVVEATRFTGWVRGLVVAFDASCSGNCTMNKAKPWDGHALLGREGAKKEGDVTFHSGVTQGRTSIYPSYHADFYAVEEDAPGDHTVRWTSQVEVRCDAELSTAGCVAPQKKPDLVLPMSVYGTAAVTYLFAETKLPDAWGTPRNPLWRIDISDKEREERYRRTCGRTGTTPFVPIPVVPDDSCDEYPFARSFQGGKYAAQCAEIIPTLENNQWVVYDADPRRPVTYREPCVRGHVPLKQNEAAGGAYGSLVKTDRILDMDPFIVSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK50</accession>
    <name>A0A2G1XK50_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_13040</name>
        <name evidence="9" type="ORF">CYQ11_17400</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51615">
        <property type="protein sequence ID" value="PHQ51615"/>
        <property type="gene ID" value="BLA24_13040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14408">
        <property type="protein sequence ID" value="PPT14408"/>
        <property type="gene ID" value="CYQ11_17400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="430" mass="45272" checksum="388E4F49EA688A49" modified="2018-01-31" version="1">MSVASVRQAVRRSVAGLPREFWWLWTSTLINRMGAFVATFLALYLTLDRGYSAVYAGLVAALHGLGGVISSLGAGVMADRLGRRPTLLIAQLSTAVTVALLGFMEHPVAVAAVAFLVGMTSTASRPAVQAMMADIVAPEDRVRAFALNYWAINLGFAFSSLAAGLVAEHSYLIGFLGEAALTLACALLVFWKLPESRPEPTAGADGAVADEDPVSLMTVLRDRRYMGVVFLSFLMAFVFMQHSVALPVAMGADGFSPGDYGTVIAVNGVLIVALQIPVTRFIEHRDPRTLLTFSALLAGYGFGLTAFAGSVGVYALTIVVWTLAEIINSPTQMGLVVRLSPAQGRGRYQGMFTLSWPAAALVAPLAGGWLIDRYGADTLWATCAVVGTVAAAGYWLLMRDLPAAEAGTGQAAAPAEQPEAAAREAEPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK53</accession>
    <name>A0A2G1XK53_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12895</name>
        <name evidence="6" type="ORF">CYQ11_17255</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51590">
        <property type="protein sequence ID" value="PHQ51590"/>
        <property type="gene ID" value="BLA24_12895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14383">
        <property type="protein sequence ID" value="PPT14383"/>
        <property type="gene ID" value="CYQ11_17255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="156"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="31612" checksum="15268637E567EFDE" modified="2018-01-31" version="1">MSRSDVLVDADWVQARIDAGDPKTVIVEVDEDTSAYDKNHIKTAVRIDWRRDLQDPVRRDFVDRAGFEELLSEKGIANDDTVVLYGGNNNWFAAYAYWYFKLYGHQDVRLLDGGRKKWELDSRDLVAEVPRRPRTTYRAKEQDTSIRAFRDDVVAAIGSLNLVDVRSPDEFSGKLLAPAHLPQEQSQRPGHVPSARNIPWSKSANDDGTFKSDAELTELYEGAGVDLAKDTIAYCRIGERSAHTWFVLHELLGQSNVRNYDGSWTEYGSLVGVPIELGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK68</accession>
    <name>A0A2G1XK68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12760</name>
        <name evidence="6" type="ORF">CYQ11_17115</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51627">
        <property type="protein sequence ID" value="PHQ51627"/>
        <property type="gene ID" value="BLA24_12760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14359">
        <property type="protein sequence ID" value="PPT14359"/>
        <property type="gene ID" value="CYQ11_17115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="28252" checksum="C0FE3C8102B19C59" modified="2018-01-31" version="1">MAKRIDVSGLTAYYGSHKAIEDISMTVEPRSVTAFIGPSGCGKSTFLRTLNRMHEVTPGGRVEGKVMLDDENLYGAGVDPVSVRRTVGMVFQRPNPFPTMSIYDNVAAGIRLNGDRVRKAELDTIVEKSLKGANLWKEVKDRLNKPGAGLSGGQQQRLCIARAIAVEPQVLLMDEPCSALDPISTLAIEDLIGELKERFTIVIVTHNMQQAARVSDRTAFFNLAGVGQPGKLVEIDDTERIFSNPSVQATEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKT6</accession>
    <name>A0A2G1XKT6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11680</name>
        <name evidence="4" type="ORF">CYQ11_02920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51853">
        <property type="protein sequence ID" value="PHQ51853"/>
        <property type="gene ID" value="BLA24_11680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16317">
        <property type="protein sequence ID" value="PPT16317"/>
        <property type="gene ID" value="CYQ11_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="328" mass="35100" checksum="8E9022B077A2C620" modified="2018-01-31" version="1">MRLLILGGTEFVGRAVTEEALARDWDVTVFHRGRHGAPPGAAELLGDRTAEGGLAALARGEWDVVVDTWSAAPTAVRDTARLLAGRAGHYAYVSTASVYAYPPPERLSEASPVVDGSPDAEARDYARDKRGGELAALDAFGDRALLLRAGLILGPYENIGRLPWWLLRIARGGPVLAPGPRDLALQYIDARDLAAWTLSAAERGLGGPYNLVSPSGHATMGGLLEACRRATGSDAELRWTDPGRIIAAGVEPWTQLPVWMPPGEMHDAFHRGDVAKAVSAGLRCRPVEDTVTDTWNWLCDLGGVAPQRPDRPPVGLDAETEAKLLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL11</accession>
    <name>A0A2G1XL11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly-gamma-glutamate biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12175</name>
        <name evidence="4" type="ORF">CYQ11_03415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51829">
        <property type="protein sequence ID" value="PHQ51829"/>
        <property type="gene ID" value="BLA24_12175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12076">
        <property type="protein sequence ID" value="PPT12076"/>
        <property type="gene ID" value="CYQ11_03415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="327" mass="34467" checksum="1E8387BEE328F57A" modified="2018-01-31" version="1">MSITVALAGDTMLGRCVAERLEQDPRPATVLSAALRGLVAGADAFVLNLECCVSDRGEPWPAPGKPFFFRAPPAAATVLADLGADCVTLANNHALDYGFDALADTRALLTRAGVRSVGAGPDPAAARRFALLEAGATRLAVVGVTDHPEDFAAGPDRPGVAYADLARGVPGWLADLVGRAAAEADAVLVTPHWGPNMTSAPPPHVRHTAAALLEAGATLVAGHSAHVFHGVADRCLFDMGDFVDDYAVDPVLRNDLGLLFLVTLDGTGPARPRPVRVEAVPLHLDFCRTTQASGDEWEWIRDRFTRACAEFGTTVTVRGERLVVDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL34</accession>
    <name>A0A2G1XL34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51940">
        <property type="protein sequence ID" value="PHQ51940"/>
        <property type="gene ID" value="BLA24_10845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="82" mass="8687" checksum="0071C758B30ACD7B" modified="2018-01-31" version="1">MLLRDHGGVFSPTAVQLHRISAENSAGGQGGRPAALRPVLLGLAEPGRSLTARREASPEGGRPVDVGERSRRQVPLRGDPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL64</accession>
    <name>A0A2G1XL64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11115</name>
        <name evidence="4" type="ORF">CYQ11_16830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51879">
        <property type="protein sequence ID" value="PHQ51879"/>
        <property type="gene ID" value="BLA24_11115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14308">
        <property type="protein sequence ID" value="PPT14308"/>
        <property type="gene ID" value="CYQ11_16830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="20404" checksum="3E4703919D39F7EA" modified="2018-01-31" version="1">MITAAVVAAGLGLSAARVQAGQVPRADYQAVAHAVAGRVGQTVEVELGVRNGGGGAADAGRAYEVTAPPGTRITSVADSGPGGPERCAANAQGAGTYLCAIGPQVAAGESETLRFHVRIDSKVEGAEGWVRIVDREATASPDPDPDNDAAPILVDVTDSGPSASGPSSRLGPVAEAGASATLLIATTSGTALSAGAIVLGVARRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL71</accession>
    <name>A0A2G1XL71_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_10605</name>
        <name evidence="8" type="ORF">BLA24_10610</name>
        <name evidence="6" type="ORF">BLA24_30305</name>
        <name evidence="9" type="ORF">CYQ11_23400</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000126">
        <property type="protein sequence ID" value="PHQ51965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000126">
        <property type="protein sequence ID" value="PHQ51966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47807">
        <property type="protein sequence ID" value="PHQ47807"/>
        <property type="gene ID" value="BLA24_30305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51965">
        <property type="protein sequence ID" value="PHQ51965"/>
        <property type="gene ID" value="BLA24_10605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51966">
        <property type="protein sequence ID" value="PHQ51966"/>
        <property type="gene ID" value="BLA24_10610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15432">
        <property type="protein sequence ID" value="PPT15432"/>
        <property type="gene ID" value="CYQ11_23400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ47807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="25474" checksum="F59F88E5ED007A19" modified="2018-01-31" version="1">MRLLLVEDDDHVAAALSAVLARHGFDVTHARSGEEALHALLPAGGVPFSVVLLDLGLPDQDGFEVCGKIRKRTATPVIMVTARADTRSKIHGLNLGADDYVVKPYDTGELLARIHAVARRTPQTESAPGQPQDPAAPQALSLGPLTIELPNRRVFVDGTTVPLTRKEFDLLALLAQRPGVVFRREQIISEVWRTSWEGTGRTLEVHIASLRSKLRLPALIETVRGVGYKIVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLL9</accession>
    <name>A0A2G1XLL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09620</name>
        <name evidence="3" type="ORF">CYQ11_28230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52164">
        <property type="protein sequence ID" value="PHQ52164"/>
        <property type="gene ID" value="BLA24_09620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16245">
        <property type="protein sequence ID" value="PPT16245"/>
        <property type="gene ID" value="CYQ11_28230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="70" mass="8145" checksum="5598F38EDCAA43E8" modified="2018-01-31" version="1">MTNPFEDPDAEYLVLVNDENQHSLWPVFADVPEGWRAVFGKAGRQDCLDYIEKSWTDMRPKSLIEAMEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLN1</accession>
    <name>A0A2G1XLN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09400</name>
        <name evidence="2" type="ORF">CYQ11_28010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52126">
        <property type="protein sequence ID" value="PHQ52126"/>
        <property type="gene ID" value="BLA24_09400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16206">
        <property type="protein sequence ID" value="PPT16206"/>
        <property type="gene ID" value="CYQ11_28010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="37120" checksum="886694F6EC9C17E7" modified="2018-01-31" version="1">MNSTDVNSSAIPARSGDVLAVVSQSGPTVTFFDALTHERLDVLEVPAQPHELLFDADRRLIYCTSAYVSGYYGANQGTARQVSVIDADARKIIDVLDTAPDHAPHGIALDRARDRLYVSVEATATAPGGVIVYDARTRERIGRIPVMADGPHWFAVTPDGRRGYSTNKEAPFVSVLDLERDEFAGRIEVPGSEGLDVSRDGAHVYVAAPHADFGAGPAARPGIRVIETATGEVVRTLPTEGMVFPVHTTATGAVLAGELRMAGAGGGVLGRQTDGVLTVFSPGTLEPAGHVQVGVFPLTITSSPDGKVGYVANVVSSTVTVVDLERLAVLTTLEVDRLGEPGAHGLAYIPAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLN6</accession>
    <name>A0A2G1XLN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09555</name>
        <name evidence="3" type="ORF">CYQ11_28165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52153">
        <property type="protein sequence ID" value="PHQ52153"/>
        <property type="gene ID" value="BLA24_09555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16234">
        <property type="protein sequence ID" value="PPT16234"/>
        <property type="gene ID" value="CYQ11_28165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="16157" checksum="1C43580170610A35" modified="2018-01-31" version="1">MSELERHPNIETAVRYHQAVARWATGEELARFFHEDAVHRELPNALFPDGVVRELPEILAAAEQGRRVLCRQHFDVVNAVAMGDQVALEVTWSGTLAVPLGELPAGHVLRAHIATFLRFRDGRIVAQHNYDCYEPLTSVSRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLQ4</accession>
    <name>A0A2G1XLQ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09290</name>
        <name evidence="3" type="ORF">CYQ11_27900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52178">
        <property type="protein sequence ID" value="PHQ52178"/>
        <property type="gene ID" value="BLA24_09290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16843">
        <property type="protein sequence ID" value="PPT16843"/>
        <property type="gene ID" value="CYQ11_27900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="33692" checksum="E0C44864619ED0EC" modified="2018-01-31" version="1">MALSEEVIPLTLDGYAYSGRIIHQPNARLAPIVFVGGAFQYQNAWGRLEQGCREAASVITVDLPGWGGADRLPAHYGFDFLTEALDQLLAKVAPSPVNVLGASYGSAVAYQWARDHPDRAERVALFGTMSHLTASARARVQLTLDLAEQERHAEFVECVLEGMMCTSPRVTVARRATVARCLTRALREMSPDDLAKYRDNSLRLLANARLPAGPPVRVPVLVATGEHDPLSTPALSREAAAQCADARFVAFRNADHLLHLECPAEVVDLLTRFFSGDSLSGLDYCHPVEHIRHRMRNALPSPRPSTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM63</accession>
    <name>A0A2G1XM63_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_07830</name>
        <name evidence="7" type="ORF">CYQ11_00265</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52354">
        <property type="protein sequence ID" value="PHQ52354"/>
        <property type="gene ID" value="BLA24_07830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11556">
        <property type="protein sequence ID" value="PPT11556"/>
        <property type="gene ID" value="CYQ11_00265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="180" mass="20132" checksum="EA2C64F6B602E037" modified="2018-01-31" version="1">MPSETLRVGAGVFIQHDDGRILLVHHAKTGYWVIPGGKAEPGETPRQCAVREAREETGLDGRPGRLLAVQHLTADRYWGSKYIADPYELFVFALHVHLDQYADIRVPDGELLGWDWYSPDERGTGHGRDRGHSQWDLRLPRGPSRAGVAAEQVPLFETMRAVRPYARDGAHPPTSHPKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM69</accession>
    <name>A0A2G1XM69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07760</name>
        <name evidence="2" type="ORF">CYQ11_00190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52342">
        <property type="protein sequence ID" value="PHQ52342"/>
        <property type="gene ID" value="BLA24_07760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11545">
        <property type="protein sequence ID" value="PPT11545"/>
        <property type="gene ID" value="CYQ11_00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="25779" checksum="345C41DB36B0F26D" modified="2018-01-31" version="1">MIEVSGDSALELVSDDDSLGGMRPFLDGDEAVLGYEPQEGFLDRCWVLHTVAVGGKKVRWEDVLACVGKRLEDWQHTPSFRVFGGFDLPEDLETPELGEIDRDSLAHLIEVLARHSPDGLRTECYWAQAAIEDIGRPVPARRGRLDEALAHYDACAWPDWTVETQFPAHWWPLEGSWFVLTNWDLSATEVFGTPALIADLLADNRLDAVRHPSIAEVQGRFAEWREQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMF3</accession>
    <name>A0A2G1XMF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08090</name>
        <name evidence="3" type="ORF">CYQ11_00535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52393">
        <property type="protein sequence ID" value="PHQ52393"/>
        <property type="gene ID" value="BLA24_08090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11595">
        <property type="protein sequence ID" value="PPT11595"/>
        <property type="gene ID" value="CYQ11_00535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="409" mass="41023" checksum="F653C36E7F7F5F5E" modified="2018-01-31" version="1">MPSLRSNPYARLFALPGARAFTAWNLLARLPMGMFGVGAVMMISAERGSYTLAGAVTATGLAATALAGPWTARLVDRYGQARVTVPAAAFAALGSLSLVLCVHADAPAWTLFASYAATATSPNTGGMSRARWAHLLRADPAALHTANAFEQAVDEVCFMLGPVLATFLCTSFFPGAGTLTATLMFVTGAVLFAAQKRTEPPVSATPLKQRSPLRGNRGLAAILAVFICTGALFGSLEVVTIGFADAQGHRAAAGAVLGLQAAGSCAAGLLYGLRRPASPASARFPRCLAAMAALALLPLLTTTAGGGLPLLAAALLLAGMATAPTMVTGMNLVQGLTPPGSLNEGMTLAVTGLLGGIAAGSATGGWAVEHLGAAGYAVPAGASAAALLVATASRRALSGRRALSVRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT5</accession>
    <name>A0A2G1XMT5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BLA24_06855</name>
        <name evidence="18" type="ORF">CYQ11_27005</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52491">
        <property type="protein sequence ID" value="PHQ52491"/>
        <property type="gene ID" value="BLA24_06855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16025">
        <property type="protein sequence ID" value="PPT16025"/>
        <property type="gene ID" value="CYQ11_27005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ52491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT16025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="30753" checksum="F31EC0688F9CE8FD" modified="2018-01-31" version="1">MPELPEVEALAGFLTERLVGRTVERVLPAAVSVLKTYDPPLGALDGREVTAVRRYGKFLGLATGDGPHLVFHLARAGWLRWRDTLPDAPPRPGKGPLALRVRLAGGGGFDLTEAGTQKRLAVYCVRDPADVPGIARLGPDPLAPEFTLEVFAGLLSGGRRQLKGVLRDQGVIAGIGNAYSDEILHAARMSPFRLAAGLTEEETAVLYEALGTTLREAVERSRGQAAADLKAEKKTGLRVHGRTGQPCPVCGDMIREVSFSDSSLQYCPTCQTGGKPLADRRLSKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX0</accession>
    <name>A0A2G1XMX0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_07360</name>
        <name evidence="6" type="ORF">CYQ11_27515</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52578">
        <property type="protein sequence ID" value="PHQ52578"/>
        <property type="gene ID" value="BLA24_07360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16116">
        <property type="protein sequence ID" value="PPT16116"/>
        <property type="gene ID" value="CYQ11_27515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="919" mass="98456" checksum="3A4F97CC9C0F290C" modified="2018-01-31" version="1">MARIRGRSWRPSGRSSTGRRPGGRHERRQGREGPRSSWARRLRSMASARSVAGQMFLLQALIVLLLVVAASVTLLYQARSDRFQAARDRSLAAAEAFAHGPGLVQTMQGPDPSAVLQPLTQAASKEGGVDFLVVMNRDGIRYTHPDPTEIGKKFVGTIGPSLAGRVTIESVNGPLGQELQVVVPVMDARGNVVGMVSSGLKVSSVSSAVDQQLPLVLGAGAAALALATGSTALVTRRLRRQTHGLGPSEMTQMYEHHDAVLHAVREGVVIVGGDGRVLLVNDEARRLLGLSPDAEGRDVAGLGLDPRMAELLASRRVVTDEVIPVGERLVAVNQRPTDRRGGPPGAVATLRDSTELRALAGKAEVARGRLRLLYDASVAIGTTLDVQRTAEELAEVASPRFADYVSVDLAEPVLRGEEPRMAVGSEAPELRRVALSGTPDDHPLYRAGEIHRFASPTPQAKGFISGHAVLVPDLAASTGWRTQDTERTQAILDYGFHSLITVPLKARGVLMGIVNFWRTGDSETFEEDDLSLAEELTARASVCIDNARRFTREHAMAVTLQHSLLPRGVPEQNALEVAYRYLPAQAGVGGDWFDVIPLPGARVALVVGDVVGHGLHAAATMGRLRTAVQNFSALDLPPDELLGHLDELVGRIDQEAAPADDEALIAGATCLVAIYDPSSGVCAMARAGHPLPALVHPEGTVEFPELPAGPPLGLGGLPFEAAELRLPEGSSLVLYTDGLVEDRKRDIDAGLDILRRTLAFPGRSPQETCEAVLGALLPSTQSDDIALLVSRTRVLEADRTAEWELPADPAVVARARADVTRQLSRWGLEEAVFTAELILSELITNAIRHASGPIRVRLLRDRMLICEVSDTSSTSPHLRYAAAEDEGGRGLFLVAQLAERWGTRYIPDGKVIWAELPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMY1</accession>
    <name>A0A2G1XMY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin biosynthesis bifunctional protein CbiET</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Precorrin-6y C5,15-methyltransferase (Decarboxylating) subunit CbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_06695</name>
        <name evidence="9" type="ORF">CYQ11_26845</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52614">
        <property type="protein sequence ID" value="PHQ52614"/>
        <property type="gene ID" value="BLA24_06695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15998">
        <property type="protein sequence ID" value="PPT15998"/>
        <property type="gene ID" value="CYQ11_26845"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="430" mass="45083" checksum="F0E6D97319688F88" modified="2018-01-31" version="1">MPLIAVDPEVPPVSPAPVTVVGIGADGWSGLAPASREALRHAEVIIGGPRQLDLLPADCPAERVAWPSPLRPAVPGLLATHAARRVCVLASGDPMFYGIGRTLADVLGADRLRVLPHPSSVSYACARLGRPLHDTDVISLVGRPLATLTAALHDGRGLLLLSAGADTPAEVAELLRRRGWGPSRMTVLEQLGGDRERRLDGTADDWPHPPGDPLNVIAVDCRRAPDALRLPLTPGLPDDAFEHDGQLTKRHVRAATLAALAPAPGELLWDVGGGSGSIGIEWMRAHPSCRAVAVERDPVRAARITRNADALGVPALRVVTGPAPAALAGLPAPDAVFIGGGLTAPGLLDACWEALPPGGRLVANTVTLESEALLTDRYRRHGGDLTRLAVAHAVPVGGFTGWRQAMPVTQWSVVKPPQEPRPTPPQEAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMY7</accession>
    <name>A0A2G1XMY7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_07510</name>
        <name evidence="6" type="ORF">CYQ11_27660</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52607">
        <property type="protein sequence ID" value="PHQ52607"/>
        <property type="gene ID" value="BLA24_07510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16144">
        <property type="protein sequence ID" value="PPT16144"/>
        <property type="gene ID" value="CYQ11_27660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="22749" checksum="9AE6020C0927FAD6" modified="2018-01-31" version="1">MPISVLLVDDEPLVRAGLRAILEAQPDIEVVAEAADGAAVVPLVRRLRPDVVAMDVRMPLLDGIEATRAVLRAVAPPPKILVVTTFENDEYVYDALRVGADGFLLKRAAPAEIVQAVRMVAAGDSLLFPASLRSLAASRGNEPARAAMEKAALTAREAEVLRLMARGLSNPEIAAGLLVGTETVKTHVSAVLAKLGARDRTQAVIAAYESGFVTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNB4</accession>
    <name>A0A2G1XNB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05360</name>
        <name evidence="3" type="ORF">CYQ11_01820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52706">
        <property type="protein sequence ID" value="PHQ52706"/>
        <property type="gene ID" value="BLA24_05360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11799">
        <property type="protein sequence ID" value="PPT11799"/>
        <property type="gene ID" value="CYQ11_01820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="270" mass="29257" checksum="D2B1BF5CA8901A89" modified="2018-01-31" version="1">MESFVLPHTVHGDGPHKVVAVHGWFADRSAFDPILPDVDRSAFQYALVDLRGYGEAKDAPGAYTTAEGAADVLAVADRLGWERFSVVGHSMGGSVAQRLLALAPDRVRRLVGISPVPASGLPLPPEQWELFSSAAHAPQNRRVIIDFTTGGKRPAGWLDRMVSRSLERSEAKAFRAWLDSWAGEDFHAEVADSTVPALAVVGTLDPALTADLMRGTWLRWYADSRLLELPSAGHYAMDETPLELIRAMEDFLRADGDGRGQAPGNGPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNC2</accession>
    <name>A0A2G1XNC2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05390</name>
        <name evidence="2" type="ORF">CYQ11_01850</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52710">
        <property type="protein sequence ID" value="PHQ52710"/>
        <property type="gene ID" value="BLA24_05390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11804">
        <property type="protein sequence ID" value="PPT11804"/>
        <property type="gene ID" value="CYQ11_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="148" mass="16279" checksum="645C0CDDB095590D" modified="2018-01-31" version="1">MPPIPVKPGIYKIHAHIIGPSALVTATEHAIKHGAPVITDRLNPLPIEQEWLIEPAEPVPGSPYVIRLAQHEEVGLVIVDDKLYVNGVQRPELATFTFERVIGGVKIISDKGLALRAGHRGAQLEVVPPKPEFQETWTLEFTSPVHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH3</accession>
    <name>A0A2G1XNH3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05720</name>
        <name evidence="2" type="ORF">CYQ11_02195</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52763">
        <property type="protein sequence ID" value="PHQ52763"/>
        <property type="gene ID" value="BLA24_05720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11864">
        <property type="protein sequence ID" value="PPT11864"/>
        <property type="gene ID" value="CYQ11_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17741" checksum="D8D7C2BEB103FAD7" modified="2018-01-31" version="1">MGVYNVHERLLAARKSEVGALIDTLAGDGDELWPHGDWPPMRFDRPLAVGAAGGHGPVRYTVTAHVPATWVRFTFRAPRGFHGFHEYAALAVDEQHTLLRHTLAMNARGPARLTWPLLWGPLHDACLEDSLDRAELAVTGTVARPARRSPYVRLLRALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNI8</accession>
    <name>A0A2G1XNI8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4956 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05935</name>
        <name evidence="4" type="ORF">CYQ11_02410</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52798">
        <property type="protein sequence ID" value="PHQ52798"/>
        <property type="gene ID" value="BLA24_05935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11900">
        <property type="protein sequence ID" value="PPT11900"/>
        <property type="gene ID" value="CYQ11_02410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="22983" checksum="5C2C459036B4B55E" modified="2018-01-31" version="1">MDSLRHLVAHLGLDLAAISLLTFAIYYPRHRRRDLVPAYLALNVALFTVVAALAEMNGNGGAALGFGLFGVLSIIRLRSDAVQHEEVAYYFVTLVLGLLCGLPHLPIGLAAALSGVLLLVVYTADHPRLLARVRRTVVTLDTVHGDPAALRADLARRLGEPLRWTVMEIDYVRDLTVVDVRYREPEPGTAPGYGTANAEPVQRTAPAWESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNU5</accession>
    <name>A0A2G1XNU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05570</name>
        <name evidence="2" type="ORF">CYQ11_02030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52819">
        <property type="protein sequence ID" value="PHQ52819"/>
        <property type="gene ID" value="BLA24_05570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16296">
        <property type="protein sequence ID" value="PPT16296"/>
        <property type="gene ID" value="CYQ11_02030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="158" mass="17506" checksum="CB492C85BCD3796B" modified="2018-01-31" version="1">MRSVFLAGPFLQLLDPATGEMPESARNPFDTLIKHFEAQRLSVHNAHRREAWGAELMRPEECTRIDQEEIRKADAFVALPGSPASPGTHIEIGWASAFDKPIVLLLERDRDYTFLVQGLHTVATVEYVVHSDIAGALPAVDTALRRAVTRHREGAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNU9</accession>
    <name>A0A2G1XNU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04955</name>
        <name evidence="3" type="ORF">CYQ11_28575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52908">
        <property type="protein sequence ID" value="PHQ52908"/>
        <property type="gene ID" value="BLA24_04955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11432">
        <property type="protein sequence ID" value="PPT11432"/>
        <property type="gene ID" value="CYQ11_28575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032169">
        <property type="entry name" value="DUF5005"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16396">
        <property type="entry name" value="DUF5005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758540" evidence="1">
        <location>
            <begin position="26"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="41572" checksum="76B87A1DCDB549A9" modified="2018-01-31" version="1">MRIPRVLVALAVAVCAFVPPGDRPAAGPPGVGRVRPATALDEAWGAYAERPGRSHWTGGDSTYSVATAAGELWVFSDTFLGTVRADGSRPPVAGAGGTTPFVHNSFVLWPAAGRPRTVTGRDRSGGPAPVVSGPSRDQWYWARAGVAEGRGAAIVYARYARTGSGPLDVAWQGNVLARFGPGRPDRPRSLTPLPSSARTAWGAWLERQGGHTYVYGTEQGPLGAHYLRLARVAGSDLRRPWQYWTADGKWSARESRSARLTGADGAALRTSDELSVVRHGRWYALVTQRSDEPFSAQVQLAWSRTPHGPFTRPRTVYTAPEAGPSGTYRNRNVIAYNPHEHPELERPGELVVSYNVNSLVPQDVIDRAGVYRPRFLRVTLGPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW3</accession>
    <name>A0A2G1XNW3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BLA24_05080</name>
        <name evidence="22" type="ORF">CYQ11_28450</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 24">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52927">
        <property type="protein sequence ID" value="PHQ52927"/>
        <property type="gene ID" value="BLA24_05080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11412">
        <property type="protein sequence ID" value="PPT11412"/>
        <property type="gene ID" value="CYQ11_28450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="21" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="21" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="POLXc" evidence="20">
        <location>
            <begin position="3"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="19">
        <location>
            <begin position="340"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PHQ52927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PPT11412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="574" mass="63390" checksum="838FD45B55CEDB26" modified="2018-01-31" version="1">MARPNEEVEALLQEYADLVAITGGDAFKARAYEKAARAIGGFPTDVSKLDVKGLRDIPNVGKSIAEKVVEFLRTGQVSDVEEVRASVPAGVRELLTIPTLGPKKAMTLYEELRVSSVDELLDAIHDKRLRDLKGFGERTEENVLHGIALMQKAGGRILLNSAMDVAEQVVAELSRVKGCEGCAYAGSLRRMRETIGDVDVLVAAERSAAFMEAFSGLPYTAEVIAHGEKKTSIRTTKGLQVDLRVLPPDSWGAGLLYFTGSKAHNIRVREMAIRHGYKLSEYGLFHAKSGKKAVSGTEEDIYAKLGLPWIPPTLREDRGEIAAALKGELPELIEEGDIRGDLHTHTDLTDGVSGLEDMVAAAADRGYAYFAITDHAPNLYMQRMTDQKILAQREKVRALDGKHRRMHVLHGTELNIGPEGDLDWPDDFLAGFDLCVASVHSHFNQSREELTRRLVRACENPYVSIIGHPTTRQIGKRPGIDADFDEVFAACARTGTALEVNSHPERLDLGDEEILRAKRYGVKFAVNTDAHSVVHLPYMRFGVGTAQRGWLTKDEVINTWPLQKLRRFLRPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNX0</accession>
    <name>A0A2G1XNX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04990</name>
        <name evidence="4" type="ORF">CYQ11_28540</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52913">
        <property type="protein sequence ID" value="PHQ52913"/>
        <property type="gene ID" value="BLA24_04990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11426">
        <property type="protein sequence ID" value="PPT11426"/>
        <property type="gene ID" value="CYQ11_28540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="20985" checksum="A0D67662DB834B33" modified="2018-01-31" version="1">MTVDFDLGPAAQRMAGLLRAVDDEWLTAPTPCERYTLGDLIEHVGGLAGAFTAAATKTAPEPAGSPPPSGDAARLETDWRTRIPERLTALADAWRDPAAWEGVTRAGGVDLPAGVAARVALDELVVHGWDVARATGQPFDCDEAELAACLEFVSGFPRPDPEERPADGGLFGPPVDVPADAPPLDRMLGLTGRDPGWTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP07</accession>
    <name>A0A2G1XP07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05260</name>
        <name evidence="2" type="ORF">CYQ11_28270</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52956">
        <property type="protein sequence ID" value="PHQ52956"/>
        <property type="gene ID" value="BLA24_05260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11382">
        <property type="protein sequence ID" value="PPT11382"/>
        <property type="gene ID" value="CYQ11_28270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="28719" checksum="11E815A66D3FBC75" modified="2018-01-31" version="1">MLLDGVTAVVTGAARGLGRACATRFAEEGADLVLVDVADDVAGVPYPLGSAAQLEHTAKLCREFGACVLTEAADVRDFAACEAVAARALDRFGAVQALVNGAGIAAPSGKAVHEIGGDEWQLMIDTDLTGAWHMMKAFVPSMIARREGSVVNVASTAGLVGYRHFAGYVAAKHGLIGLTKAAALDYAPFRVRVNALCPGSVRDDPLVEGRMLAEIARSLDVAVEEHEEVFSRRQPMNRLIEPQDVAGAALWLSGRDSRQVTGATVTVDGGFTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPD7</accession>
    <name>A0A2G1XPD7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000052">
        <property type="protein sequence ID" value="PHQ53080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53080">
        <property type="protein sequence ID" value="PHQ53080"/>
        <property type="gene ID" value="BLA24_03745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="95" mass="9780" checksum="720D30073DC8D9A4" modified="2018-01-31" version="1">MTAPTLLDRFARQVADHPDAVALRHTGTSLTYRELDEWAGRLAARLAAKGTGPGSLVALAADRGPAAVAGVLAVLKTGAAYLDWTRRPPCGASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPH9</accession>
    <name>A0A2G1XPH9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BLA24_03370</name>
        <name evidence="18" type="ORF">CYQ11_16915</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53123">
        <property type="protein sequence ID" value="PHQ53123"/>
        <property type="gene ID" value="BLA24_03370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14324">
        <property type="protein sequence ID" value="PPT14324"/>
        <property type="gene ID" value="CYQ11_16915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304810" description="Adenine DNA glycosylase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ENDO3c" evidence="16">
        <location>
            <begin position="89"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ53123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT14324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="342" mass="36572" checksum="14D6C36C7E3807DA" modified="2018-01-31" version="1">MTAMPPTPSVPSARSSRPAAAISTSRTSASPTSAPHTSVPRTSGPPAPTPQTSTLLHSPVIDWFEVHARDLPWRRPEAGPWGVMVSEFMLQQTPVSRVLPVYEQWLSRWPRPADLAAEPPGEAVRAWGRLGYPRRALRLHAAASAITERHGGEVPDDHAKLLALPGVGEYTAAAVASFAYGQRHAVLDTNVRRVFARAMTGIQYPPNATTAAERKLARALLPQEEAVAARWAAATMELGALVCTARTPSCARCPIAAHCAWLAAGSPAHDGPPRRGQTYAGTDRQVRGKLLAVLREAVAPVPRSVLDAVWDEPVQRARALDGLVADGLVEPLAGGMYRLPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPN8</accession>
    <name>A0A2G1XPN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone PCu(A)C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02250</name>
        <name evidence="2" type="ORF">CYQ11_04610</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53183">
        <property type="protein sequence ID" value="PHQ53183"/>
        <property type="gene ID" value="BLA24_02250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12275">
        <property type="protein sequence ID" value="PPT12275"/>
        <property type="gene ID" value="CYQ11_04610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="18168" checksum="84650F23E5838C30" modified="2018-01-31" version="1">MNPSHPKNPNGPAKDSLLRTARAALVPLAAGAVALGGLTAWTASGAAGRPAAVTVEDASVLVPFGIDDTAAMVRLRNTGDADDELVGVDVPSAGGAMLSRTVVRNGAGSMRMVASATVPAHGTLEMSPHGLDIMVYRPPKVRVGDRLPFVLRFRKSGTVRGEALVVRAGSRPKAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPQ9</accession>
    <name>A0A2G1XPQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02395</name>
        <name evidence="3" type="ORF">CYQ11_04760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53206">
        <property type="protein sequence ID" value="PHQ53206"/>
        <property type="gene ID" value="BLA24_02395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12298">
        <property type="protein sequence ID" value="PPT12298"/>
        <property type="gene ID" value="CYQ11_04760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="39949" checksum="7A607551442B7FB2" modified="2018-01-31" version="1">MDGSTDGRTDPGDPRVRRARLAIAAVFAVHGAVSGNLATRIPWIQEHTGIGPGLLGLALTCPAVGAALAMPLAGRVGHRYGSRAGLRALLCLLCASLALPALCPGLVALCGAMAVYGAASGMADVAMNALGVRTEELLGRPVMSGLHGMWSVGALAGSAAGTVAAHTGTGARLHLGLAAVVLLGLGVLVCHGVLDLRPGPDEDAPPRFALPRRAVLAIGAVGFCAVFAEGASLDWSAVYLRDVIGSDAGVAAACTTAFSCTMAVARLAGDAVVGRFGPVRTVRAGGVLAGLGGILVVCAHEAVQAMAGFGLLGLGIAVVVPLAFAAAGRSGPEPSGAIAGVATITYTSWLVAPGLIGQLAHATSLTVSFTLVTVTAAGLTVVAGALRTPSGHAVETAAVSSPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPV0</accession>
    <name>A0A2G1XPV0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="15">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">carB</name>
        <name evidence="19" type="ORF">BLA24_02715</name>
        <name evidence="20" type="ORF">CYQ11_05010</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="15"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53243">
        <property type="protein sequence ID" value="PHQ53243"/>
        <property type="gene ID" value="BLA24_02715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12336">
        <property type="protein sequence ID" value="PPT12336"/>
        <property type="gene ID" value="CYQ11_05010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="133"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="682"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="955"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="15">
        <location>
            <begin position="1"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="15">
        <location>
            <begin position="955"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="832"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="844"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="846"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PHQ53243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PPT12336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1103" mass="117965" checksum="70E6D6EF96DD2273" modified="2018-01-31" version="1">MPKRTDIQSVLVIGSGPIVIGQAAEFDYSGTQACRVLKSEGLRVILVNSNPATIMTDPEIADATYVEPITPEFVEKIIAKERPDALLPTLGGQTALNTAISMHENGVLEKYDVELIGANVQAIHKGEDRDLFKGVVEAVNAKIGHGESARSVICHTMDEVLAGVDTLGGYPVVVRPSFTMGGAGSGFAHDEEELRRIAGQGLTLSPTTEVLLEESILGWKEYELELMRDKHDNVVVVCSIENFDPMGVHTGDSITVAPAMTLTDREYQILRDVGIAIIREVGVDTGGCNIQFAVNPEDGRVIVIEMNPRVSRSSALASKATGFPIAKIAARLAVGYTLDEIPNDITEKTPASFEPTLDYVVVKAPRFAFEKFPAADATLTTTMKSVGEAMAIGRNFTEALQKALRSLEKKGSQFDFVSEPGDKAELLEKAVRPTDGRINTVMAAIRAGATPEEVFDATKIDPWFVDQLFLIKEIADELAAAEKLLPELLAEAKRHGFSDAQIAAIRGLREDVVREVRHALGVRPVYKTVDTCAAEFAAKTPYFYSSYDEESEVAPREKPAVIILGSGPNRIGQGIEFDYSCVHASFALSEAGYETVMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEIVHAEQQAGPVAGVIVQLGGQTPLGLAQALKDNGVPIVGTSPEAIDLAEERGAFGRVLTEAGLPAPKYGTAYSFDEAKGIAAGIGYPVMVRPSYVLGGRGMEIVYDEPSLAGYLERHAGLISEHPVLIDRFLDDAIEIDVDALYDGHELYLGGVMEHIEEAGIHSGDSACALPPITLGGYDIKRLRASTEAIAKGVGVRGLINIQFAMAGDILYVLEANPRASRTVPFTSKATAVPLAKAAARISLGATVAELRAEGMLPAQGDGGTLPLDAPISVKEAVMPWSRFRDIHGRGVDTVLGPEMRSTGEVMGIDTVFGTAYAKSQAGAYGALPTKGRAFVSVANRDKRSMIFPARELVAHGFELLATSGTAEVLRRNGINATVVRKQSEGEGPNGEKTIVQLIHEGQVDLIVNTPYGTGGRLDGYEIRTAAVARAVPCLTTVQALAAAVQGIDALTRGEVGVRSLQEHAEHLTAAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPW4</accession>
    <name>A0A2G1XPW4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53253">
        <property type="protein sequence ID" value="PHQ53253"/>
        <property type="gene ID" value="BLA24_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="215" mass="23151" checksum="AC67C19045700363" modified="2018-01-31" version="1">MQYPAGPPLPPAQPPMPAAPPPRPEPVAVHDPSTAPVAVLLIGPAGAGKTTVARYWADTRRVPTAHISLDDVREWVRSGFADPQSGWNDHSEAQYRLARRTCGFAARNFLANGISCILDDAVFPDRPVVGLGGWKRHVGPGLLPVVLLPGLEVVLERNAERSGNRRLSDEEVARIHGRMAGWYGSGLPIIDNSQQDVATTARLLDEAVARALTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPX2</accession>
    <name>A0A2G1XPX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03010</name>
        <name evidence="4" type="ORF">CYQ11_05310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53295">
        <property type="protein sequence ID" value="PHQ53295"/>
        <property type="gene ID" value="BLA24_03010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12392">
        <property type="protein sequence ID" value="PPT12392"/>
        <property type="gene ID" value="CYQ11_05310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="15649" checksum="4A67C3BB374DEF65" modified="2018-01-31" version="1">MLISTVCAAVSAAGLGIALLTAYRKRFLAATRIAAYALVPIGLVLTGVIDWVTDLVFKPSVWAGFGILALSAALFMISRAVERRRGGTRKERRRAAAAGRPEALAPTASAPSLGSPRQAERPKAGKAKPPQGDGEDFSDIEAILKKHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPZ1</accession>
    <name>A0A2G1XPZ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DsbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03015</name>
        <name evidence="3" type="ORF">CYQ11_05315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53296">
        <property type="protein sequence ID" value="PHQ53296"/>
        <property type="gene ID" value="BLA24_03015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12393">
        <property type="protein sequence ID" value="PPT12393"/>
        <property type="gene ID" value="CYQ11_05315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="171" mass="18766" checksum="5CFD5F4A94F935A3" modified="2018-01-31" version="1">MSDTDPLPTVRPVLDVWCELQCPDCHQALDDLRALRARYGDRLEIRLRHFPLEKHKHAYAAAQAAEEAAEQGQAWPYVEAVLARTGELAERGEKLLVEVAGELGLDAEEVDTALIDGRHMLIVDADQAEGKAMGVTGTPTYVIDGVRLDGGKSQEGLRERVEEIADRLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ13</accession>
    <name>A0A2G1XQ13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02470</name>
        <name evidence="2" type="ORF">CYQ11_04835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53337">
        <property type="protein sequence ID" value="PHQ53337"/>
        <property type="gene ID" value="BLA24_02470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16355">
        <property type="protein sequence ID" value="PPT16355"/>
        <property type="gene ID" value="CYQ11_04835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="242" mass="25034" checksum="6569B1D9EEF0CBE9" modified="2018-01-31" version="1">MSPEPTVENGGSHRLALGVDTAQPLSEFLIGELDGLCDRIEDAGGSAVAVIRLGDATAVTPGTGWPGEVGIHLVNKWERALRRLERVGAVTVAVAAGAAGGPALEVLLACDYRIGGSAMRLSLPGRDGEPWPGMLVHRLANQLGPTRARHLVLFGGEISATQALQLGVLDDVVDDTDSAVAAKAASLTHLTGTELAVRRRLLLDATTTSFEEALGAHLAACDRALRRARPTGPTAPADPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ53</accession>
    <name>A0A2G1XQ53_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">BLA24_03185</name>
        <name evidence="10" type="ORF">CYQ11_05485</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53321">
        <property type="protein sequence ID" value="PHQ53321"/>
        <property type="gene ID" value="BLA24_03185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12418">
        <property type="protein sequence ID" value="PPT12418"/>
        <property type="gene ID" value="CYQ11_05485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="305" mass="32294" checksum="1CAAC7E2B8F1FB99" modified="2018-01-31" version="1">MSGSTPTTRRHTALPKARTLVEALPWLTRHHGKTVVIKFGGNAMVDDDLKAAFAQDVVFLRHAGLHPVVVHGGGPQISAHLDRLGLESEFKAGLRVTTPEAMEAVRMVLAGQVQRELVGLLNQHGPLAVGLTGEDAHTMTAVKHFAELDGERVDIGRVGEVTDIDTGAIRALLDNGRIPVVSSIARGADDGGIYNVNADTAAAALAAALGAETLMVLTDVEGLYADWPNSDDVISQLTASELERLLPELASGMVPKMQGCLHAVRNGVTTARVIDGRVQHAILLEIFTDEGIGTMVVPDPEQGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ72</accession>
    <name>A0A2G1XQ72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000030">
        <property type="protein sequence ID" value="PHQ53360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53360">
        <property type="protein sequence ID" value="PHQ53360"/>
        <property type="gene ID" value="BLA24_01720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="450"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="546" mass="58709" checksum="855042F296987300" modified="2018-01-31" version="1">MQDVPLTVTRILAHGSTVHANAHVTTWTGEGAPRRRSFAEVGARATRLAHALRALGVREGDPVGTLMWNNADHVEAYLTVPSMGAVLHTLNLRLPPEQLAWIVRHAADRVVIVNGSLLPLLAPLLPHLDCVEHVVVSGPGDLSALEGCRPQVHAYDELIAGSPAESYDWPELDERQAAALCYTSGTTGDPKGVVYSHRSIYLHAMEVNAAASFGLKPGETCLPVVPMFHVNAWGLPHAAFMAGTSLLMPDRFLQPAPLAEMIESERPTVTAGVPTIWQGLLAELDAKPRDVSSLRTVVSGGSACPPSLMKAFEERHGLTLVQAWGMTETSPLGTVAHPPPGLGAEEAWPYRITQGRMPVSVEARLIGPGGETLPWDGRSAGELEVRGPWIAGAYHGGADGEPQRPEDKFSEDGWLRTGDVGTITADGFLTLTDRAKDVIKSGGEWISSVELENHLMAHPQVAEAAVVAVPDEKWGERPLAAVVLKDGSSVGYEGLRAFLSERIARWQLPERWALVPAVPKTSVGKFDKKVLRRQYADGELVVTTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQE8</accession>
    <name>A0A2G1XQE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00470</name>
        <name evidence="2" type="ORF">CYQ11_07480</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53443">
        <property type="protein sequence ID" value="PHQ53443"/>
        <property type="gene ID" value="BLA24_00470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12748">
        <property type="protein sequence ID" value="PPT12748"/>
        <property type="gene ID" value="CYQ11_07480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="19517" checksum="9F5DB1AE8FAAA92B" modified="2018-01-31" version="1">MSDLMEVDGLQEMIAQLVEKRAREVAEEPGAYSLIQLRPSATEEQLAELQSVVGQALEPRYREFLSVSDGLDNFYFEMPILGCQDWPESAALIRAQSFLELILDMGTLEDEGLPSTSRLVPVSVDEDETNGIFMIDTLGATQDRFWWVGEGSSLLFPDFAAVMAYVIDPAGYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQH1</accession>
    <name>A0A2G1XQH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00585</name>
        <name evidence="4" type="ORF">CYQ11_07595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53463">
        <property type="protein sequence ID" value="PHQ53463"/>
        <property type="gene ID" value="BLA24_00585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12768">
        <property type="protein sequence ID" value="PPT12768"/>
        <property type="gene ID" value="CYQ11_07595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305623" evidence="2">
        <location>
            <begin position="43"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="21112" checksum="0CD8E9F90E37A1FD" modified="2018-01-31" version="1">MDISAARLRALRAALFSALCVLLSAASHVLLSGRPLPGPAVAAASAAVFVLAYALAGAERGYGRIAALLVPLELASCALFTAGQDTCYGSGGRPSAGALTWLCSGSVGQPLAGLAAPGTAPWLVLAGHVVTGLLAALWLRRGEAALGRLLRAAAAVAFRPLLLAAATLTAGGRVRGRAAVRVPNGTRPARPLPPFLHSVVRRGPPALPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQT9</accession>
    <name>A0A2G1XQT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000008">
        <property type="protein sequence ID" value="PHQ53583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53583">
        <property type="protein sequence ID" value="PHQ53583"/>
        <property type="gene ID" value="BLA24_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="71" mass="7520" checksum="FAFC1521C11ED910" modified="2018-01-31" version="1">MDGVSTYLALTFGTLLSSQGTDASFVLTLSGFPPGASLRCFQPYQIRFRSVSGSDSVSGPLLERGFSRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQV7</accession>
    <name>A0A2G1XQV7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-(1-2)-phosphatidylinositol mannosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00980</name>
        <name evidence="3" type="ORF">CYQ11_07990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53571">
        <property type="protein sequence ID" value="PHQ53571"/>
        <property type="gene ID" value="BLA24_00980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16420">
        <property type="protein sequence ID" value="PPT16420"/>
        <property type="gene ID" value="CYQ11_07990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="41167" checksum="2A50B95D9EE62F06" modified="2018-01-31" version="1">MHKTLIVTNDFPPRPGGIQAFLHNMALRLDPERIVVYASTWKRGREGAEATARFDAEQPFPVVRDRTTMLLPTPRVTRRAASLLREHGCSSVWFGAAAPLGLMAPALRRAGARRLVATTHGHEAAWAQLPGSRQLLRRIGEGTDTITYLGEYTRVRIASALTDEAAARMTQLPPGVDEKAFHPASGGEEVRSRLGLADRPVVVCVSRLVPRKGQDTLIQAMPRVLAALPDAVLLIVGGGPYAEDLRKLAADSGVAHAVRFTGPVEWEELPAHYGAGDVFAMPCRTRRGGLDVEGLGIVYLEASATGLPVVAGDSGGAPDAVLEGETGYVVRGGSPAEAADRIVTLLRDPGLRRRMGERGRAWVEERWRWDLLAERLKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9L8</accession>
    <name>A0A2G1X9L8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30930</name>
        <name evidence="4" type="ORF">CYQ11_24030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47916">
        <property type="protein sequence ID" value="PHQ47916"/>
        <property type="gene ID" value="BLA24_30930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15541">
        <property type="protein sequence ID" value="PPT15541"/>
        <property type="gene ID" value="CYQ11_24030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="123"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="455"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="990" mass="109853" checksum="AEA2DD0267A1C023" modified="2018-01-31" version="1">MAEQGQTRYPPGAQILVRDEEWLVRTARRTDHDGDRIEAIGVSEFVRDEEAVFFTGIDTVELLEPEKTLLVPDTSSYFRRARLFLEAVLRKTPLPQSERGLALADRFLLDPLAHQQRPAELALSMRNLRPRILIADVVGLGKTLEIGLTLAELIRRGRGERILVVTPQSVLEQFQHELWTRFSIPLVRLDSLGIQRIQREIPAGRNPFTHYKRVIISVDTLKNIGQYRHHLERIQWDAVVIDESHNLINQGSQRRALAETLSPRTDALLLASATPHNGDKRSFADLVSLLDPAAIVDRDHYDPAGDLGHLFIRRTKISPEVRNGIGDEWADRGPTLSLHCPATEAEERIFAELTEHWLPAPSGSTEFGTADRERTSVSTDPLFAYNVLKTFLSSHIALKETVERRVVALGKKARDMAAEGRQPDPAIGEEQAALARLGALIDSMGDGRAPGDSAKLDALVEQLKDIGVGPGSDTRTVVFSERVPTLKWLAEVVPARLGFTPGKDGKTKAVRVMHGGLSEEEQRLIREEFSLAGAPVRLLFTGDVASEGVNLHRQCHHLIHYDIPWSLIRIEQRNGRIDRYGQRHEPQFRALILTSAQPGAKDDRTVAEKLLAREEEAHKLNGTAEAETGYYRADEEERRLIRELVEGRTVEDFLASAPAADDADLAGLFGQVDTITEGEPPKRAELLSLFDGDAAAFVDTALAELYEDRAEDLIGLSRREDALDRPYLSLSPAKAPDLLRRLKALPPSYLKEQGVAERMILTFDRGLAQEKLTEAREATGTIWPTVSFLSDIHPVVEWLTDKVLVQFGRQEAPVITSPYVDHPTFLIQGIYSNALGRPTVVRWMAVSADPDVPVGTMTDALHAAKVGPALARTGDPRDLAHLQSLVPAAVARARAHLETYKDEWAEQISGPLAEYRARLSDWRQDSLDSLSGGSARRERQIEETADEQAHLLDQLTTTGLPLLRVLAVLDKPAADAPDHTSDNASESAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA27</accession>
    <name>A0A2G1XA27_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32050</name>
        <name evidence="4" type="ORF">CYQ11_25105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48078">
        <property type="protein sequence ID" value="PHQ48078"/>
        <property type="gene ID" value="BLA24_32050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15704">
        <property type="protein sequence ID" value="PPT15704"/>
        <property type="gene ID" value="CYQ11_25105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="119" mass="13090" checksum="902A00F79AB34904" modified="2018-01-31" version="1">MGGEGGVRHPISISSTRLRYFVAVAEELHFGRAAAREYIAQPTLSQQIKCLEKEIGAVLFERTRRTVTLTPAGHRFLAGSREVLESLHRIVQEAREVARQDPGEVPAGTAEAARRVPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAN0</accession>
    <name>A0A2G1XAN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33390</name>
        <name evidence="3" type="ORF">CYQ11_26440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48297">
        <property type="protein sequence ID" value="PHQ48297"/>
        <property type="gene ID" value="BLA24_33390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15928">
        <property type="protein sequence ID" value="PPT15928"/>
        <property type="gene ID" value="CYQ11_26440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="133" mass="14662" checksum="F351AD5979EC9E64" modified="2018-01-31" version="1">MGDTHADNSALTGKVLSHAIWAEDGRRLAEFYAAALGAQVSEPYRDEDGNPAAFPVWVGDMMYVFWSATSFKAPTWPQDELPFHMDIRFDDIEAAEKRLLELGATKPAHQPGGGHWTVLLDPSGQPFCISSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAW9</accession>
    <name>A0A2G1XAW9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32720</name>
        <name evidence="2" type="ORF">CYQ11_25770</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48378">
        <property type="protein sequence ID" value="PHQ48378"/>
        <property type="gene ID" value="BLA24_32720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16804">
        <property type="protein sequence ID" value="PPT16804"/>
        <property type="gene ID" value="CYQ11_25770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="25934" checksum="4D225E521DAE925D" modified="2018-01-31" version="1">MTARFTGKTVLVTGGGTGIGRAVALAFAREGAAVVVAGRRAEPLEETVALVEATGGVASAVTADVTRSEDVRNLVERTVERHGGLDIAVNNVGMFVRPAKVADIPEDDWHAIMSTNLTGAWLSMKHEIDHMRAHGGGAVVNVSSNLGAHLRKPGLGAYSAGKAALSALTRTAALDHIADGVRVNAVSPGPIDTSMSSWPGESAKDKAERMKHEVPAGRAGAPDEVAAAVLYLASEEAGFTVGTELVLDGGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB22</accession>
    <name>A0A2G1XB22_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29005</name>
        <name evidence="4" type="ORF">CYQ11_06470</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48423">
        <property type="protein sequence ID" value="PHQ48423"/>
        <property type="gene ID" value="BLA24_29005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12581">
        <property type="protein sequence ID" value="PPT12581"/>
        <property type="gene ID" value="CYQ11_06470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="220"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="600" mass="66988" checksum="BADA967759147EC7" modified="2018-01-31" version="1">MAGRIEDYALIGDMQTAALVCRDGTADWLCLPRFDSHAAFAGLLGTEEHGYWRIGPAHPAGATPPRADRRRYRGDSLVLESEWDTERGTVRIIDFMPPRDGAPQLIRIVEGVTGRVPMRSALRMRFSYGRVVPWVHKVGDRTVAVAGPDSVWLDTTAETFGKDLTTYSDFTVAPGERVAFTISWQPSHGEPPALPDPEGSLEATEEFWREWVGHCTYHGPYRDAVVRSLITLKALTYAPTGGIVAAPTTSLPEEIGGVRNWDYRYTWLRDAAITLSSLLRTGYREEARAWREWLLRAVAGDPENLQIMYGIAGERELGEAELPWLPGYENSGPVRVGNGAAGQLQLDVYGEVTEALHLAHMTGLARNDYASLLQLRLIGYLEDHWTEPDEGIWEVRGPRRHFVHSKVMAWVAVDRTIKLIESGDVDGPLERWRELRDDIHRDVCERGYDKERNTFTQSYGSQELDASLLLIPQMGFLPPDDKRVIGTIEAIQRELSTPDGFVLRYPTAGHEAGVDGLEGDEGAFLACSFWLADDLAMIGRVDEARQLFEKLLALRNDLGLLAEEWDPRLKRQVGNFPQAFSHVPLIDTALRLTASSAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB39</accession>
    <name>A0A2G1XB39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FadR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_06365</name>
        <name evidence="10" type="ORF">BLA24_06375</name>
        <name evidence="8" type="ORF">BLA24_08430</name>
        <name evidence="7" type="ORF">BLA24_13605</name>
        <name evidence="6" type="ORF">BLA24_30080</name>
        <name evidence="11" type="ORF">CYQ11_01325</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000166">
        <property type="protein sequence ID" value="PHQ48399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000091">
        <property type="protein sequence ID" value="PHQ52297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000078">
        <property type="protein sequence ID" value="PHQ52638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000078">
        <property type="protein sequence ID" value="PHQ52640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48399">
        <property type="protein sequence ID" value="PHQ48399"/>
        <property type="gene ID" value="BLA24_30080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51534">
        <property type="protein sequence ID" value="PHQ51534"/>
        <property type="gene ID" value="BLA24_13605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52297">
        <property type="protein sequence ID" value="PHQ52297"/>
        <property type="gene ID" value="BLA24_08430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52638">
        <property type="protein sequence ID" value="PHQ52638"/>
        <property type="gene ID" value="BLA24_06365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52640">
        <property type="protein sequence ID" value="PHQ52640"/>
        <property type="gene ID" value="BLA24_06375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11718">
        <property type="protein sequence ID" value="PPT11718"/>
        <property type="gene ID" value="CYQ11_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="244" mass="26236" checksum="9B3167DED117E8AC" modified="2018-01-31" version="1">MYAAGDNRGRVQSPHETRASVEPPALRRAAWERAAASRAEGAAEHIATMIARAEPGERLGTKDELRAACGVSVGTFNETLRLLQSRGLVTVRPGPGGGLFAAEQSLMRRLGNSVLALDAHSADGVRAEEVRRIRDALSPLLVEDALWHASPADIAALRRELAELATAVRTSDPVAFAAADHRLHSRLLAVSPDGLLRSLYATLLPLAGPEADDRLQERYEHHVALIDALEAHDRTRALGLTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB67</accession>
    <name>A0A2G1XB67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29245</name>
        <name evidence="3" type="ORF">CYQ11_06230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48456">
        <property type="protein sequence ID" value="PHQ48456"/>
        <property type="gene ID" value="BLA24_29245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16375">
        <property type="protein sequence ID" value="PPT16375"/>
        <property type="gene ID" value="CYQ11_06230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="12770" checksum="E27361829F5B81A5" modified="2018-01-31" version="1">MTVDPDAAEPPYEQIRARIAERARSGALPVGYKLPTVRGFAEELGLAANTVAKAYRALEADGVIETRGRNGTFIAAPGDTAAREAASAARAYAERAQRLGLGREAALDAVRDALRAVYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB73</accession>
    <name>A0A2G1XB73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29215</name>
        <name evidence="5" type="ORF">CYQ11_06260</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48451">
        <property type="protein sequence ID" value="PHQ48451"/>
        <property type="gene ID" value="BLA24_29215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12553">
        <property type="protein sequence ID" value="PPT12553"/>
        <property type="gene ID" value="CYQ11_06260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="254"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="513" mass="53144" checksum="961A8AE5768EF95C" modified="2018-01-31" version="1">MTERSTPPPAPVSALDLVAAVVDPGTWRCWDEPVPLAADDPAYRADLLAARERTGLDESVVTGEGRVRGRRVAVVACEFRFLGGSIGVAAGERLVRAVERATAERLPLLAAPASGGTRMQEGTIAFLQMVKVTAAITDHKAAGLPYLVHLRHPTTGGVLASWGSLGHLTAAEPGALIGFLGPRVHEALYGEEFPPGVQVAENLLANGLVDAVLPAGLLAEATARALSVLCADDAGSTTAGVPAPAQAALAEAPSAEESIRRSRRPDRPGVREFLRVTAADVTPLSGTGAGERDPGLLLALARVGGTPCVVLGHDRGTRDGTPVDGAPARGQALGPAGLRAARRGMRIAAELDLPLLTIVDTAGAALSREAEEGGLAGEIARCLADLVALPAPTVCLLLGQGAGGAALALLPADRVVAARHAWLSPLPPEGASAILYRTTERAHEVAERQGVRSADLLAKGIVDRIVEEEGDFLSTLGRVIGAEMAALRASDRRERRAARRARYRRLGGPDRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBD0</accession>
    <name>A0A2G1XBD0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29755</name>
        <name evidence="5" type="ORF">CYQ11_05720</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48538">
        <property type="protein sequence ID" value="PHQ48538"/>
        <property type="gene ID" value="BLA24_29755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12462">
        <property type="protein sequence ID" value="PPT12462"/>
        <property type="gene ID" value="CYQ11_05720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305485" evidence="3">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="227" mass="23407" checksum="BB30B8CBFB88BCCB" modified="2018-01-31" version="1">MNRVRTALAALVVAAFALPPAATATAAPSGSDDSDSSGSSISSRGTTQRGREITFTVTTSQSVLDDNGGRLTVESPAFAKKLTLKAKRFREGKDGSLYTQVAGMVLCDIQPGTYPVELKAGDDEPEDTDEMTVVADMDPGNRDFCDSPRNYDEVVDRTSETAPDDDSDDDDTTIGPGALAAVIAGTAALAAALASAATYLLTRRRGRGGDGGSGDGGKGETPQDPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBJ4</accession>
    <name>A0A2G1XBJ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29020</name>
        <name evidence="4" type="ORF">CYQ11_06455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48580">
        <property type="protein sequence ID" value="PHQ48580"/>
        <property type="gene ID" value="BLA24_29020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16383">
        <property type="protein sequence ID" value="PPT16383"/>
        <property type="gene ID" value="CYQ11_06455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="48"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="674" mass="71569" checksum="88558FD2D5C7D335" modified="2018-01-31" version="1">MTPRQAPAPAPCFAPAGPFVGRQRELKELRADIVRAGLDTLSGRKRPRGRVLLIAGRPGSGRTALAEELARQLAGDYPDGVLRARLTGADGEPVPTERTARALLGALNAPVPAGAREDELTEALRAALNGRRVLLLLDDAAGAGQVDPLLPDEPECLVVAVSRGPLTGVPDVRPCTLGGLDTPAAVELLERYAGPTRITCDPVAASAVVEECGGQPAALVLVGGWLAARPKMSVVDVAKRLRELPAGGPAAGREGAARPLARAFWLAYEALPPSSARLLHLLALAPAGLADAHTASALAGCALTTAQSALEDLTARGLLRGEAPEGAEGALPPQYRVPGCLAELLGALLQAQERPAEIELARARMLERTVRQLHSCRAATEQDDPAVRRRIEQLPRPLRFPSRPAAEEWLLARLPALLAAARLAVEDGRLDTLARRLVSALTRALTAHLGPEAAAPDLYGLHQLVLDVARRCEMPLEKAAALLNLGDLDARGGRTPEALERYRQALQSAREAGDPYATSRALESIGAAHQELGDWQRAADWYRRSLELRLTRGELADEARLYGRLGAVHGYAGQWSEALRDWRAAAAAHRRLRDQAGQARALGEAARVLEQAGRSREALRTGLEAMECARRAGDGRLEAAARLRLADTLDRLGDGAAAEAHRRAAHELLGEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBS1</accession>
    <name>A0A2G1XBS1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28630</name>
        <name evidence="3" type="ORF">CYQ11_06835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48676">
        <property type="protein sequence ID" value="PHQ48676"/>
        <property type="gene ID" value="BLA24_28630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12643">
        <property type="protein sequence ID" value="PPT12643"/>
        <property type="gene ID" value="CYQ11_06835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="14924" checksum="FF4FAE16C6E9A27A" modified="2018-01-31" version="1">MAQISTAAPAVCPALLYRDARAAIRQLTEAFGFTRTALYESEDGTVLHAELMWGNGIVMIGSRGRGGVFDEAVKDAGPSGVYVAVEDPDAHHRRAVAHGAEVLAPPADQEYGSRDYTARDLEGNLWTFGTYAPKGPETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBV9</accession>
    <name>A0A2G1XBV9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28575</name>
        <name evidence="3" type="ORF">CYQ11_06890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48737">
        <property type="protein sequence ID" value="PHQ48737"/>
        <property type="gene ID" value="BLA24_28575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16392">
        <property type="protein sequence ID" value="PPT16392"/>
        <property type="gene ID" value="CYQ11_06890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="13741" checksum="4397927E9F9C2F66" modified="2018-01-31" version="1">MGGGPRHGGAVRGRGGGRAVNAVLYVGVGACRDVAAAEVLALVEHALAEAGGGAVAALATVDVRADEPGMLAAAARLGVPLTAYAPGVLAAQPVPHPSEAARRALGTPGVAEAAALLAAGPGAVLAVPKRKSAHVTAAVACRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY3</accession>
    <name>A0A2G1XBY3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_28830</name>
        <name evidence="13" type="ORF">CYQ11_06635</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48711">
        <property type="protein sequence ID" value="PHQ48711"/>
        <property type="gene ID" value="BLA24_28830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12608">
        <property type="protein sequence ID" value="PPT12608"/>
        <property type="gene ID" value="CYQ11_06635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="186"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="381" mass="40452" checksum="6E886ACA1514843B" modified="2018-01-31" version="1">MTMGPRSGLTAVSTALLAMSRHLEVRDVLKTIVASARELLDAEYAALGVPDDHGGFAQFVVDGVSEEEWRAIGPLPRQHGILASMLSDATPQRLADVRLDPRFGGWPEAHPDMSDFIGMPVADGDEILGALFLANKRCPKVEGGCSFTAEDEELLAVLAQHAAIALTNARLYERSRELTIAGERARLAHELHDAVSQKLFSLRLTAQAATALVDRDPARAKGELHQVARLAAEAADELRAAVVELRPAGLDEDGLIATLRTQVKVLDRAHSARVTFAAHGVRALPAAQEEALLRVAQEALHNALRHSGAQAVDVVLTRQGPGAVLRVTDDGTGFDPSAVRRAGRHLGLVSMRDRANGVGGALAVLSEPGKGTTIEMEVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC70</accession>
    <name>A0A2G1XC70_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48810">
        <property type="protein sequence ID" value="PHQ48810"/>
        <property type="gene ID" value="BLA24_27465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="262" mass="27877" checksum="DC264DA0C654C960" modified="2018-01-31" version="1">MGQDDISAAAAVRIEGLWKRFGEQVAVAGIDLELPAGRFVGLVGPNGAGKTTTLSMITGLLRPDSGRVEIAGHDVWQDPAAVKARIGVLPEGLRMFERLSGRELLAYTGRLRGLPGDEVDQRATQLLDVLDLAGAQHKLVIDYSTGMRKKIGLAAALLHNPEVLFLDEPFEGVDPVSAQTIRTVLERYTASGATVVFSSHVMELVESLCSWVAVMAGGRIRAQGPLAEVRGDAASLQEAFLALVGARGRAQDDSLDWLGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM6</accession>
    <name>A0A2G1XCM6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27105</name>
        <name evidence="7" type="ORF">CYQ11_18535</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000155">
        <property type="protein sequence ID" value="PHQ48945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48945">
        <property type="protein sequence ID" value="PHQ48945"/>
        <property type="gene ID" value="BLA24_27105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14598">
        <property type="protein sequence ID" value="PPT14598"/>
        <property type="gene ID" value="CYQ11_18535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304573" evidence="4">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="262" mass="28015" checksum="4180F3F97128C66C" modified="2018-01-31" version="1">MTSTAFAGGLSSPLGATAVAARATDLTKVYGQGETQVVALDAVSVEFRQAEFTAIMGPSGSGKSTLMHCMAGLDSVSGGSARIGDTELTALNDKKLTQLRRDKIGFIFQAFNLLPTLTALENITLPMDIAGRKPDRKWLEMVVETVGLSGRLKHRPSQLSGGQQQRVAVARALAGRPEIMFADEPTGNLDSRSGAEVLGFLRNSVRELGQTVVMVTHDPVAASYADRVVFLADGRIVDELHRPTADAVLDRMKRFDAKGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCN8</accession>
    <name>A0A2G1XCN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF503 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23020</name>
        <name evidence="2" type="ORF">CYQ11_23055</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48980">
        <property type="protein sequence ID" value="PHQ48980"/>
        <property type="gene ID" value="BLA24_23020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15375">
        <property type="protein sequence ID" value="PPT15375"/>
        <property type="gene ID" value="CYQ11_23055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="10920" checksum="AAECB53AF0B2023A" modified="2018-01-31" version="1">MYVGTLSFDLLLGDVRSLKEKRSVVRPIVAELHRKYAVSVAEVGDQDLYRRATIGVAAVSGDAGHLTDILDRCERLVAARPEVELLSVRRRFHGDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCS9</accession>
    <name>A0A2G1XCS9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ORF">BLA24_23415</name>
        <name evidence="20" type="ORF">CYQ11_22655</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49043">
        <property type="protein sequence ID" value="PHQ49043"/>
        <property type="gene ID" value="BLA24_23415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15311">
        <property type="protein sequence ID" value="PPT15311"/>
        <property type="gene ID" value="CYQ11_22655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15 20" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PHQ49043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PPT15311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="33057" checksum="9FB446124C95081B" modified="2018-01-31" version="1">MPELPEVEVVRSGLERWVCGRTVAEVEVLHPRAIRRHLAGPADFAARLTGQRLGLAHRRGKYLWLPVESPARPEPARQAVLAHLGMSGQLLVQPQGSPDEKHLRVRVRFADAAATELRFVDQRTFGGLSLHDTVPGDPEGLPDVIAHIARDPLDPAFDDRAFHAALRRRRTTVKRALLDQSLISGVGNIYADEALWRTRLHYDRPTATLTGPRTAELLLHIREVMNEALAAGGTSFDSLYVNVNGESGYFDRSLDAYGREDEPCRRCGTAIRRRPWMNRSSYFCPRCQRPPRPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT8</accession>
    <name>A0A2G1XCT8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ORF">BLA24_23470</name>
        <name evidence="6" type="ORF">CYQ11_22600</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49053">
        <property type="protein sequence ID" value="PHQ49053"/>
        <property type="gene ID" value="BLA24_23470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15301">
        <property type="protein sequence ID" value="PPT15301"/>
        <property type="gene ID" value="CYQ11_22600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="156"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="33662" checksum="B9EE550081F0477F" modified="2018-01-31" version="1">MKGTVGELGEFGLIRELTSRLTTTPAVRLGPGDDAAVVAAPDRRVVASTDVLLEGRHFRRDWSTAYDVGRKATAQNLADIAAMGAVPTAVLLGLVVPAELPATWPTELMDGIRDECQVAGAAVVGGDVVRGETITVAITALGDLRNHEPVTRSGARAGDVVAVTGWLGWSAAGLAVLSRGFRSPRAFVEAHRRPEPPYHAGPAAAALGATAMTDVSDGLIADLGHIAEASKVRIDLRTAAIDVPTQMSDIGQAVGVDPLQWVLTGGEDHAIVATFPPDVKLPARWKVIGEVVNPSALPQVTVDGAPWDKAGGWDHFGDLEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCX8</accession>
    <name>A0A2G1XCX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA carboxylase subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23625</name>
        <name evidence="2" type="ORF">CYQ11_22445</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49078">
        <property type="protein sequence ID" value="PHQ49078"/>
        <property type="gene ID" value="BLA24_23625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15276">
        <property type="protein sequence ID" value="PPT15276"/>
        <property type="gene ID" value="CYQ11_22445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
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    </dbReference>
    <dbReference type="GO" id="GO:0003989">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="66" mass="7094" checksum="4081424A36856632" modified="2018-01-31" version="1">MNDTLVRVEKGTADAEELAAVTAVLLARAAAGTGRAAQAPARRRTPVGWRRLERTPGFRAPHSWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD62</accession>
    <name>A0A2G1XD62_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24330</name>
        <name evidence="5" type="ORF">CYQ11_21740</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49197">
        <property type="protein sequence ID" value="PHQ49197"/>
        <property type="gene ID" value="BLA24_24330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15153">
        <property type="protein sequence ID" value="PPT15153"/>
        <property type="gene ID" value="CYQ11_21740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="110" mass="12061" checksum="16294731E9A55AC7" modified="2018-01-31" version="1">MHIRGDHAELVVGGRLDVRSAADARTVLHSALDAGRGDLVLDLTELDSWDATGLGVIMGAHRRAGRTGRRLVLRGVPDRMQRVLVATRLHRILAIEEDTGADHRRPLPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD73</accession>
    <name>A0A2G1XD73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24380</name>
        <name evidence="4" type="ORF">CYQ11_21690</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49207">
        <property type="protein sequence ID" value="PHQ49207"/>
        <property type="gene ID" value="BLA24_24380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15143">
        <property type="protein sequence ID" value="PPT15143"/>
        <property type="gene ID" value="CYQ11_21690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="187"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="401" mass="41953" checksum="D79A74B854C18BA3" modified="2018-01-31" version="1">MPVRFPSRLPDREAVLIAAAGLLGGALLYALGLNNRPEAELPQWLALVALALMAGAELLRRTAPLVGLAVGTGALVVDVCSGSLFANVAMYTDLVYSAVLYGPPEAYRRIPRVTEAVTVVGTLVAVVLIREPVALLIGIGLGVVTVAPAWTGVGVRVHRDAAEAARMAAERTALLAELDRREAVGAERARMARELHDMVAGHLSAIAIHSSAALSINEPEASREALGVIRENSVQGLAEMRRLIGLLRETVGADEPAATPRLDGLDALVAQARRGVRDDRFAFVLSDGRGAGALPAPVELAAYRIVQESLTNVVKHAASGEVTVELRRADAGSGPLTVEVTSPLGDGRAGPRAPGAGAGLVGMRERVALLGGEFEAGPAEGRTGRVWRIRAVLPVDEEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC0</accession>
    <name>A0A2G1XDC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24535</name>
        <name evidence="4" type="ORF">CYQ11_21535</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49234">
        <property type="protein sequence ID" value="PHQ49234"/>
        <property type="gene ID" value="BLA24_24535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15114">
        <property type="protein sequence ID" value="PPT15114"/>
        <property type="gene ID" value="CYQ11_21535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="25767" checksum="18386DC5A7D4A170" modified="2018-01-31" version="1">MTGSGTASYRRLSVTERRAQLITAALGLFAHRAPEDISLDDVAAAAEVSRPLVYRYFPGGKAQLYEAALRSAADDLELCFAEPQTGPLTGRLAAALDRYLAFVDEHDAGFSALLQGGSVAETSRTGAIVDEVRRAAAAQILKHLSVPAPGVRLRMMVRTWITAVEAASLIWLDEEKQPPRQELRDWLVDHFVALLTATAASDPQTARVTRSALAMEPADGPVGDLARRVAPVVAEAAHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDU3</accession>
    <name>A0A2G1XDU3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25270</name>
        <name evidence="3" type="ORF">CYQ11_20800</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49361">
        <property type="protein sequence ID" value="PHQ49361"/>
        <property type="gene ID" value="BLA24_25270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14990">
        <property type="protein sequence ID" value="PPT14990"/>
        <property type="gene ID" value="CYQ11_20800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="136"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="27494" checksum="FF8D4F3CE3594AB3" modified="2018-01-31" version="1">MAATDRAGLGAPCWVSLLTGDLTAAQNFYGAVMGWTFRKGSLGEGFAVALKDGKPAAGMGDVATRMGVPVSWTCYFAIDDADLVSSRVRERGGTVAVGPLAVGKGRVVLAADPAGAVFGFWQGENLPGWRIGGGEAPAWLELRTRDAFAMAMFYGEIFDWAVDRPDRCEVRYEDEAVTVRAGGSTVACIRGGAIEADPDPRIRPRWHVYFRVDDVEKAVESALGAGGAVVSEPSHTMVGREATLRDPQGGLFTVTEGSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDY3</accession>
    <name>A0A2G1XDY3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_25490</name>
        <name evidence="8" type="ORF">CYQ11_20585</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49401">
        <property type="protein sequence ID" value="PHQ49401"/>
        <property type="gene ID" value="BLA24_25490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14949">
        <property type="protein sequence ID" value="PPT14949"/>
        <property type="gene ID" value="CYQ11_20585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="35405" checksum="1CF2BB49DAA7B9FC" modified="2018-01-31" version="1">MLRFLARRILGAIVIILLISAITFFLFFALPSEPALMSCGKNCTPDAIALINKNLGLDAPVPVQYWHYMAGIFAGRDFSVGHCPAPCFGYSFSHQQPVWDTIVDRFPTTLSITLGGAVVFLVVGVGLGMLAAAYRGTWVDKLFSSLSLVGNALQIYFVGVIALAVLVSGLHWMDNPAYHPITENPVKWFTGMLIPWLVLSVIFVASYCRMTRSQMIEQLAEDHVRTARAKGLSRRTVFFRYAWRGALAPIVTIFGIDLGSLFGGAIITEFTFSLHGLGRLAVSSVSETDLPTLMAVMLVGCTAIVLANIVVDAAYALIDPRVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL7</accession>
    <name>A0A2G1XEL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, SARP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27050</name>
        <name evidence="7" type="ORF">CYQ11_18580</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49670">
        <property type="protein sequence ID" value="PHQ49670"/>
        <property type="gene ID" value="BLA24_27050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14607">
        <property type="protein sequence ID" value="PPT14607"/>
        <property type="gene ID" value="CYQ11_18580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="254" mass="27996" checksum="6F6C7EFCB2305D8B" modified="2018-01-31" version="1">MDDDGVLIPIGAPMLRATLAALALRAGHVVPVGELMDQLWGGRPPATAGATLRNYIKRLRKVIPKDRIRTESGGYRLDVEPADVDVLRFRELRACARALTGSDPQAAARTLDAALALWRGTPFTDLGDGPLRSLEQPRLEDLYLATVEERFAIGLDLGEHHVLVDEIMVMSQVYYLRERLLHQLIVALYRCGRTAEALAAYRSARKRLVAELGIEPGMHLRKLEQAILRSDPELAGERSGWAGVPSRAPLQRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEQ6</accession>
    <name>A0A2G1XEQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23800</name>
        <name evidence="3" type="ORF">CYQ11_22270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49702">
        <property type="protein sequence ID" value="PHQ49702"/>
        <property type="gene ID" value="BLA24_23800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16723">
        <property type="protein sequence ID" value="PPT16723"/>
        <property type="gene ID" value="CYQ11_22270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="33154" checksum="7ED3EB9FE3A84EC7" modified="2018-01-31" version="1">MPGGDAREAAKTVTGSLESLPYLPELPARGPGADMIGRTAGLLVEVFAHVEPSGWRISDRPGRDTRRARSWLGEDLDALEEFTQGYGGPLKVSAVGPWTLAAALELRGGEAALSDAGACRDLTASLAEGLRAHLAEVRRRVPGARIVLQLDEPSLPAVLRGQVRTASGYRTHRAVDRAVVEGALRDLAAVAGETPGGALVVHSCAPGVPFALLRHAGVAGVSFDFSLLTEREDDAIGETVEAGTKLFAGVVPGTDGPLSDPAGSVMGVRTLWRRLGLSPGTLAESVVITPSCGLAGASPAYARAALAHCVRAAKSLADNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XER8</accession>
    <name>A0A2G1XER8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThiF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25080</name>
        <name evidence="4" type="ORF">CYQ11_20990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49728">
        <property type="protein sequence ID" value="PHQ49728"/>
        <property type="gene ID" value="BLA24_25080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16697">
        <property type="protein sequence ID" value="PPT16697"/>
        <property type="gene ID" value="CYQ11_20990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="161"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="412" mass="41627" checksum="02C950923F08AF6A" modified="2018-01-31" version="1">MEKGKAGRPAPAGAGGLSAGPVRAGAAALPDSAHPMIKPALRRAWRNRDSVQFGAAPAHAVVVGPLDTATSCFLGLLDGTRGMPLLREEARRIGLPEGRADAVVERLAGAGLLDDPRGGGEGAAALRGRGGDGLARLRPDLGSLSVLHAEPGAPMRLMAARQSMRVQVRGAGRVGATVAALLSASGVGRVDVLDGGCVEPWDVAPGGVRTGRSGERRDATVRQVVREAAPVPPPRARAGGGDRGSDAVPRLALVILAPRDGLAAYAPDVAASEELLLSGTPHLYAGVLEATGVVGPLVLPGGTACAGCVELARAERDPAWPRMLAQWRSGRAAGVPSCDMALATVVAGLTVARALAFLDGGSTSGAGVRLELALPGPAWTPRPVEPHPRCPCGAAGSPHPGMPESHGHRTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF10</accession>
    <name>A0A2G1XF10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3995 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19410</name>
        <name evidence="3" type="ORF">CYQ11_11390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49818">
        <property type="protein sequence ID" value="PHQ49818"/>
        <property type="gene ID" value="BLA24_19410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13406">
        <property type="protein sequence ID" value="PPT13406"/>
        <property type="gene ID" value="CYQ11_11390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025058">
        <property type="entry name" value="DUF3995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13160">
        <property type="entry name" value="DUF3995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="204" mass="21484" checksum="BADAFB71C7341826" modified="2018-01-31" version="1">MSITRSPDDIARRVPRRAVRLHLSAWPGYAAAGWGFLFAVPSFVWATGSTFGARTTVSPSLVQLARDGVPWFVAVLVVTGFLKLVGALLGIGLTRARGARISRFMVFCGGGAAILLTWHGGLFVVHGVLAEAGAVSVEPDLAALTSWYLYLWGPWFIVGGLAFAGATALYVRPRGDRRELRLYGAVGALGALILSVTSAATGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF28</accession>
    <name>A0A2G1XF28_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integration host factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19485</name>
        <name evidence="5" type="ORF">CYQ11_11310</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004951951.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49830">
        <property type="protein sequence ID" value="PHQ49830"/>
        <property type="gene ID" value="BLA24_19485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13395">
        <property type="protein sequence ID" value="PPT13395"/>
        <property type="gene ID" value="CYQ11_11310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="9777" checksum="FB7AAC2BFF118ECD" modified="2018-01-31" version="1">MNRSELVAALADRAEVTRKDADAVLAALAETVGEVVAKGDEKVTIPGFLTFERTHRAARTARNPQTGEPIQIAAGYSVKVSAGSKLKEAAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFL9</accession>
    <name>A0A2G1XFL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20720</name>
        <name evidence="3" type="ORF">CYQ11_10060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50036">
        <property type="protein sequence ID" value="PHQ50036"/>
        <property type="gene ID" value="BLA24_20720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13186">
        <property type="protein sequence ID" value="PPT13186"/>
        <property type="gene ID" value="CYQ11_10060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045436">
        <property type="entry name" value="DUF6507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20117">
        <property type="entry name" value="DUF6507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="131" mass="13546" checksum="88FDF2EE6C31CF7D" modified="2018-01-31" version="1">MGGKWDIQLDGVRAALGHTGEVAGKFEEEFTSYGEHVSGAATSAGTMALGGATAPEGGFVGPVGAALKEFADGTENDLRFLPVRAGKSIKGAREAAEAYQQGDLEMAQNKEDAALKAPTPEELKPPKDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS8</accession>
    <name>A0A2G1XFS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20820</name>
        <name evidence="4" type="ORF">CYQ11_09960</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50051">
        <property type="protein sequence ID" value="PHQ50051"/>
        <property type="gene ID" value="BLA24_20820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13170">
        <property type="protein sequence ID" value="PPT13170"/>
        <property type="gene ID" value="CYQ11_09960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="29796" checksum="64C29677E9BB4259" modified="2018-01-31" version="1">MTYPQQPGPYGQPGPPAQPGYGQGHGYAHPQQPAPGPYPYAAYGQPGAPGPYPPPVPPGNGGRAGKVVGVVFAGLVLVTAIAGGGLLLYKTRSGHDPVGGDGKRYMLTTPATILGGAYVKAAGAGEGLNSSDLRDLRRLGVTDPETASAAYDGGTGLDKKQIRWTGTWGRIKEPEAVVNGMFAALAHFSEQEKNGERLELVGPPRKVSPDGLDDAVMKCQTARVSNTLTQDRPMTMPVCVWADHSTAAEVFTIDAAAVATGKETSLSEAATLAAKVRRDVRTEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFU2</accession>
    <name>A0A2G1XFU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Phospholipid carrier-dependent glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_21210</name>
        <name evidence="10" type="ORF">CYQ11_09575</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50108">
        <property type="protein sequence ID" value="PHQ50108"/>
        <property type="gene ID" value="BLA24_21210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13111">
        <property type="protein sequence ID" value="PPT13111"/>
        <property type="gene ID" value="CYQ11_09575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="8">
        <location>
            <begin position="107"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="548" mass="58281" checksum="30AF5D36C5A9A4BD" modified="2018-01-31" version="1">MTTTLPTAAAPAAAPPTAPTPLRPVLRLRRSRPDLLLCGALLAAVLLVQGWNTPGFPALSDDEGTYLAQAWAVQQGEGLAHYTYWYDHPPLGWIQLAALTWPASLFSPGTLTVAPMRGAMLLVTAASAVLVYVLGRRLGLAPWAAGLGMLLFGLSPLAVVLQREIFLDNIAVMWILLAFCLAASPRRHLWHHFGAGLAAAVAVLSKETMLVVLPALLVTMWRHSHRDTRKFAVTGAVTACGLVGLAYPLFALLNHELFPGPGHVSLIEGVRYQMSRAGSGFLLDSGSSAHAVLRSWLYYDRVLPLCGLAAAVLLLVAARCSRTGRALAGPALAAVILALVALRPSGYLPAMYVVQALPFLALALAAAATAATGALLRTRPEGGPRWRAVRWGAVGVLAATAAALVVPRWYDGDRTAMTTDANAPYRGAAHWLRDRDHVADPAGTRVLADDAIWLDLVHAGYRPGTGAIWFYKADLDPAVAATLPRGWRDVDYVVASPTVRRDAATLPLVRAALEHSEAVASFGEGEDRIEIRRVAGAGRSLTKTKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFU6</accession>
    <name>A0A2G1XFU6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="11" type="ORF">BLA24_21230</name>
        <name evidence="12" type="ORF">CYQ11_09555</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50112">
        <property type="protein sequence ID" value="PHQ50112"/>
        <property type="gene ID" value="BLA24_21230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13107">
        <property type="protein sequence ID" value="PPT13107"/>
        <property type="gene ID" value="CYQ11_09555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="178"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="302" mass="33388" checksum="F844BB01688D53DA" modified="2018-01-31" version="1">MSVRELVVLGTASQVPTRHRNHNGYVLLWDGEGILFDPGEGTQRQMLRAGVAAHDLNRICVTHFHGDHSLGVAGVVQRINLDRVPHPVTAHYPASGRRFFERLRYATAYKETVKLTEEPVAGTGAVLARTGSYVLEARRLSHPVESYGYRLVEPDGRRMLPERLAERGVSGPDVGRLQREGSVGGVTLDEVSEVRRGQRFAFVMDTRLCAGVHELAEGCDMLVIESTFVDEDETLAGEHGHLTAGQAARVAVEAGVRHLVLTHFSQRYDDPAVFERQARAAGFEGELTVARDLMRVPVPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFU9</accession>
    <name>A0A2G1XFU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21255</name>
        <name evidence="5" type="ORF">CYQ11_09530</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50116">
        <property type="protein sequence ID" value="PHQ50116"/>
        <property type="gene ID" value="BLA24_21255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13103">
        <property type="protein sequence ID" value="PPT13103"/>
        <property type="gene ID" value="CYQ11_09530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="65"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="40057" checksum="0E955EB0C832A47A" modified="2018-01-31" version="1">MTVPSPHPAGSPEERFEGAAPVLDPLAEVRSESDPLTDVYLTGTVFLDIIFTGLDSAPVRGTESWARGMGSSPGGIANMATALARLGLRTSLAAAFGDDMYGEYCWESLSRGEGIDLSLSRTVPGWHSPVTVSMAYEGERTMVSHGHEAPPPEEPAPECPPPARGCVALLVPGRQEEWIATAARRGSRVFADVGWDETGRWDPADLADLEHCEAFLPNAEEAMRYTRTDDPRAAARALADKVPVAVVTMGERGAYAVDGGTGESAEVPAIAVEALDPTGAGDVFVAGFVTGTLAGWPLADRLAFAGLTAALSVQEFGGSLSAPGWVEIAAWWQHVRSFDDQTRSTLRRYAFLDGVLPAAARPWPLRRAVPTLGFRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFW3</accession>
    <name>A0A2G1XFW3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="10" type="ORF">BLA24_21325</name>
        <name evidence="11" type="ORF">CYQ11_09460</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50128">
        <property type="protein sequence ID" value="PHQ50128"/>
        <property type="gene ID" value="BLA24_21325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13091">
        <property type="protein sequence ID" value="PPT13091"/>
        <property type="gene ID" value="CYQ11_09460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="248" mass="26686" checksum="226FA9A8061081D8" modified="2018-01-31" version="1">MSLFRDDGIVLRTQKLGEADRIITLLTRGHGRVRAVARGVRRTKSKFGARLEPFSHVDVQFFARGSELVGRGLPLCTQSETIAPYGGGIVTDYARYTAGTAMLETAERFTDHEGEPAVQQYLLLVGGLRTLAAGEHAPHLILDAFLLRSLAVNGYAPSFGACAKCGMPGPNRFFSAAAGGVVCGECRVPGSVVPSSESIELLGALLTGDWATADACEARYVREGSGLVASYLQWHLERGLRSLRYVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG94</accession>
    <name>A0A2G1XG94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxide stress protein YaaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22090</name>
        <name evidence="2" type="ORF">CYQ11_08695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50252">
        <property type="protein sequence ID" value="PHQ50252"/>
        <property type="gene ID" value="BLA24_22090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12963">
        <property type="protein sequence ID" value="PPT12963"/>
        <property type="gene ID" value="CYQ11_08695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="27148" checksum="521C43D2E6B384B0" modified="2018-01-31" version="1">MLVLLPPSEGKATGGTGPALEIAGLALPALGRARESVLDELVELCSGDEEKAAEVLGLSPGLRGEVAKNAGLRTAGTRPAGEIYTGVLYDALGLATLAGPARRAAGRSLLVFSGLWGAVRVDDAIPSYRCSMGVKLPGLGALAAHWRAPMAEALPEAAGDGLVLDLRSAAYASAWKPKGSLAERTATVRVLQSKVVDGVEKRSVVSHFNKATKGRLVRELLTTGSAPATPAELADALRDLGYTVEGAAPAGAGRPWALDVVVTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGC0</accession>
    <name>A0A2G1XGC0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_22270</name>
        <name evidence="11" type="ORF">CYQ11_08515</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50282">
        <property type="protein sequence ID" value="PHQ50282"/>
        <property type="gene ID" value="BLA24_22270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12932">
        <property type="protein sequence ID" value="PPT12932"/>
        <property type="gene ID" value="CYQ11_08515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="29"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="276" mass="29715" checksum="A7717E4F84A708E4" modified="2018-01-31" version="1">MSATTTAAPPKARPRTGEGRIGLRANLRHIGALARRNALQIKADPESMYDAVLMPVIFILLFTYVFGGSIVGKGQEEQYVNYLVPGLMAMMGLNISMAVGQGINDDFKKGVMDRFRTMPIARSSVLIAKIVVEIGRMLVATTILLVMGLCMGLHISTSVFHLLGAVALSMAFGASLMWIFILLGLTLKNAQAVQGMAMIVLMPLQFGSSIFSSPSNMPGWLETFTKYNPLSNLADAARNLINGGPVAHAVWMTLGWSVAITVVTAPLAIAKFRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGJ2</accession>
    <name>A0A2G1XGJ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01090</name>
        <name evidence="1" type="ORF">BLA24_22690</name>
        <name evidence="2" type="ORF">BLA24_22705</name>
        <name evidence="4" type="ORF">CYQ11_08100</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50351">
        <property type="protein sequence ID" value="PHQ50351"/>
        <property type="gene ID" value="BLA24_22690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50352">
        <property type="protein sequence ID" value="PHQ50352"/>
        <property type="gene ID" value="BLA24_22705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53556">
        <property type="protein sequence ID" value="PHQ53556"/>
        <property type="gene ID" value="BLA24_01090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12861">
        <property type="protein sequence ID" value="PPT12861"/>
        <property type="gene ID" value="CYQ11_08100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="72" mass="7754" checksum="6DA7B0C89918489D" modified="2018-01-31" version="1">MPKTVKDVTPAREPESLAELRRDCARMAPHWTGVAAPAGRPRPHGTPLSLIHGVVVPARSARLLDAMSDYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGN3</accession>
    <name>A0A2G1XGN3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20780</name>
        <name evidence="3" type="ORF">CYQ11_10000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50387">
        <property type="protein sequence ID" value="PHQ50387"/>
        <property type="gene ID" value="BLA24_20780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13176">
        <property type="protein sequence ID" value="PPT13176"/>
        <property type="gene ID" value="CYQ11_10000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="6853" checksum="785457CE363588DF" modified="2018-01-31" version="1">MVISLSVVLLFGIILVVMVRSNKLKMGPALVAILFGFFLASTGMAPSINRLVSSVAETINNIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGS5</accession>
    <name>A0A2G1XGS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19115</name>
        <name evidence="3" type="ORF">CYQ11_11615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000149">
        <property type="protein sequence ID" value="PHQ50440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50440">
        <property type="protein sequence ID" value="PHQ50440"/>
        <property type="gene ID" value="BLA24_19115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13448">
        <property type="protein sequence ID" value="PPT13448"/>
        <property type="gene ID" value="CYQ11_11615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="32414" checksum="AEC6658BC33F5210" modified="2018-01-31" version="1">MIPLRPLAVGEIIEGSVSTLRRHWRTALGVSLAVAVGTQAVATVVERFRPRGSSALTTPEELADATPREVLHALGESLTEIATTSVIGLIGSIVASAMLTVVVSRAVLGRPVTARDAWANARPRLPAMAGLFCVIPLLIVGAFAVGTAPGLVLVAAGAEQAGLSLTLLGGMAGLVGSVWLWIRYSLAAPALMLERQGVMASLRRSEKLVRGSWGRIFGIQILAGLLVFLVATIVALPTSPIEFMITGEAGSDDPSSWTNLIFTGVAATISSMIALPITSGMTALLYMDQRIRRESLDIELTRAASVGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH53</accession>
    <name>A0A2G1XH53_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17250</name>
        <name evidence="4" type="ORF">CYQ11_16025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50562">
        <property type="protein sequence ID" value="PHQ50562"/>
        <property type="gene ID" value="BLA24_17250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14184">
        <property type="protein sequence ID" value="PPT14184"/>
        <property type="gene ID" value="CYQ11_16025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_C" evidence="2">
        <location>
            <begin position="97"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="24830" checksum="D620EF2C25347C4B" modified="2018-01-31" version="1">MSMLTPPGMGGKYRITGHRFPHMRRPRNRRRIVLASVATAAVLGLAGWGTLQLVDVFSGGGGGTEAAAPAKKSTDCKNGGAQAAGRKAPKELPKPGDITVNVYNATPRGGLAKITADELERRGFKIGKVGNAQSDYDKKVTGTGVLLGSREALDGALKVLGTQLTGTEAKSDQREGQDVDLVLGDGYKTLTPKEDADRLLTALEDQSHQSPSASAPAPSSGAPKDSPGQGRADGAKGSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH75</accession>
    <name>A0A2G1XH75_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_17350</name>
        <name evidence="6" type="ORF">CYQ11_15925</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50577">
        <property type="protein sequence ID" value="PHQ50577"/>
        <property type="gene ID" value="BLA24_17350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14169">
        <property type="protein sequence ID" value="PPT14169"/>
        <property type="gene ID" value="CYQ11_15925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="146"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="27755" checksum="D2677E3DB5FCA4DC" modified="2018-01-31" version="1">MTTAPPTGRTQLLHDDGSAVRVLVVDDEAPLADLLSLALRYEGWEVRAAADGTEAIRTARDFRPDAVLLDMMLPDMDGLSVLGRLRREQPDVPVLFLTAKDSVEDRVAGLTAGGDDYVTKPFSLEEVVARLRGLLRRSRAAVPRAESVLTVGDLVLDEDSHEVSRGGTEIHLTATEFELLRFLMRNPRRVLSKPQILDRVWSYDFGGQANVVELYISYLRRKIDAGRAPMIHTRRGAGYLIKPAVQPATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL1</accession>
    <name>A0A2G1XHL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1,2-phenylacetyl-CoA epoxidase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18185</name>
        <name evidence="2" type="ORF">CYQ11_15090</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50715">
        <property type="protein sequence ID" value="PHQ50715"/>
        <property type="gene ID" value="BLA24_18185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14032">
        <property type="protein sequence ID" value="PPT14032"/>
        <property type="gene ID" value="CYQ11_15090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030200">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02157">
        <property type="entry name" value="PA_CoA_Oxy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="95" mass="10804" checksum="F4146CBE31B85F75" modified="2018-01-31" version="1">MTSTDWPLWEVFVRSRRGLSHTHAGSLHAPDAEMALRNARDLYTRRSEGVSIWVVPSVAVTASSPDEKDPFFEPAADKPYRHPTFYEIPEGVRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL8</accession>
    <name>A0A2G1XHL8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18235</name>
        <name evidence="3" type="ORF">CYQ11_15040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50723">
        <property type="protein sequence ID" value="PHQ50723"/>
        <property type="gene ID" value="BLA24_18235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14022">
        <property type="protein sequence ID" value="PPT14022"/>
        <property type="gene ID" value="CYQ11_15040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="13"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="38070" checksum="07EF05E45ED04C03" modified="2018-01-31" version="1">MTTAAVGTDRKPATMAQALCRAMRDAMAEDPAVHVLGEDVGTAGGVFRVTDGLAKEFGEDRCTDTPLAEAGILGTAVGMAMYGLRPVVEMQFDAFAYPAFEQLVSHVSRMRNRTRGAMPMPITIRVPYGGGIGGVEHHSDSSEAYYLATPGIHVVTPATVADAYGLLRAAIASDDPVVFLEPKRLYWSKADWDPERPEPVPGIGRAVVRRRGGSATLITYGPSLPVCLEAAEAAVAEGWDLEVIDLRSLMPFDDETVCASVRRTGRAVVVHEATSFGGPGGEIASRITERCFHHLEAPVLRVAGFDIPYPPPMLEKHHLPGVDRVLDAVARLQWEADWTATDHPTPTAYESGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHV1</accession>
    <name>A0A2G1XHV1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">BLA24_18760</name>
        <name evidence="12" type="ORF">CYQ11_14520</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50810">
        <property type="protein sequence ID" value="PHQ50810"/>
        <property type="gene ID" value="BLA24_18760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13932">
        <property type="protein sequence ID" value="PPT13932"/>
        <property type="gene ID" value="CYQ11_14520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="428" mass="45924" checksum="07082B90C8F1284E" modified="2018-01-31" version="1">MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVVGDQKYALHLLPSGILSPGCTPVIGNGVVVDPAVLLSELSGLNERGVDTSKLLLSGNAHLITPYHTTVDKVTERFLGKRKIGTTGRGIGPTYADKINRVGIRVQDLYDESILTQKVEAALDFKNQILAKLYNRRAIDAAQIVDELLGYADQIKPFVADTTLILNNAIDDGKVVLFEGGQGTLLDVDHGTYPFVTSSNPTAGGACTGAGVGPTKINRVIGILKAYTTRVGAGPFPTELFDKDGEALRTIGGERGVTTGRDRRCGWFDAVIARYATRVNGLTDFFLTKLDVLTGWEQIPVCVAYEIDGKRVEELPYSQSDFHHAKPVYEMLPGWTEDISKAKTFSELPKNAQAYVKALEEMSGAPISAIGVGPGRDETIEINSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI62</accession>
    <name>A0A2G1XI62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylamine--glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18805</name>
        <name evidence="2" type="ORF">CYQ11_14475</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50819">
        <property type="protein sequence ID" value="PHQ50819"/>
        <property type="gene ID" value="BLA24_18805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13923">
        <property type="protein sequence ID" value="PPT13923"/>
        <property type="gene ID" value="CYQ11_14475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="492" mass="54373" checksum="FAF5995793AE3496" modified="2018-01-31" version="1">MGMDQIRRWESGALAHAVSDPFGQGPLPWLRGDESYFDDTGQIIPWYVDPPPASPGAHVPPPRRAGPRAADDVHCQIKGFATASAVAPGESIDFRITVDPPQQFGVDVYRIGHYGGIGAAKMTSSPRLSGIVQPPPLVFDRTVSCHHWWLSWRLTIPSFWTAGAYVAVLTTADGYRSHIPFTVRDSTPADLLLVLPDITWQAYNLYPEDGRTGASLYHAWDDDGRLLGEEGAATTVSFDRPYAGAGLPLHVGHAYDFIRWAERYDYHLAYAETRDLHAGRIDPARYRGIVFPGHDEYWSPAMRRAAEEARDGGTSLVFLSANTMYWQVELAPSPAGPDRLLTCRKRRGPGRSALWRDMSPPEQQLLGIQYAGRVPEPAPMVVRNAGHWLWEATGAGEGDELPGLVAGEADRYFPRTALPEHTRRILLAHSPYQDGEGARRHQETSLYRAPSGALVFASGTFAWSPALDRPGHVDARVQRATANLLDRICKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI81</accession>
    <name>A0A2G1XI81_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14280</name>
        <name evidence="3" type="ORF">CYQ11_13795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50958">
        <property type="protein sequence ID" value="PHQ50958"/>
        <property type="gene ID" value="BLA24_14280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13820">
        <property type="protein sequence ID" value="PPT13820"/>
        <property type="gene ID" value="CYQ11_13795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6884" checksum="376C69182057F7A3" modified="2018-01-31" version="1">MSQEPQWQKSSFSGANGENCVEVAQHGRTVWIRESDTPETVLATNPTNVRAFLRSLKEQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XII6</accession>
    <name>A0A2G1XII6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">glmS</name>
        <name evidence="12" type="ORF">BLA24_14915</name>
        <name evidence="13" type="ORF">CYQ11_13155</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51068">
        <property type="protein sequence ID" value="PHQ51068"/>
        <property type="gene ID" value="BLA24_14915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13709">
        <property type="protein sequence ID" value="PPT13709"/>
        <property type="gene ID" value="CYQ11_13155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="11">
        <location>
            <begin position="288"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="11">
        <location>
            <begin position="461"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="616" mass="66287" checksum="1AAE946842A0BDC9" modified="2018-01-31" version="1">MCGIVGYVGGQSALDVVLAGLRRLEYRGYDSAGVAVLADGGLAAAKKAGKLANLEKELSDRPLPSGPTAVGHTRWATHGGPTDANAHPHLDNPGRVAVVHNGIIENFAALRAELADRGHTLESETDTEVVAHLLSEVFSSCGDLAESMRQVCRRLEGAFTLVAVHADEPDVVVGARRNSPLVVGVGDGENFLASDVAAFIAHTREAIELGQDQVVELRRDGVQVTDFDGASATDVRAYHVDWDASAAEKGGYDYFMLKEIAEQPRAVADTLLGRIDAAGSLTLDEVRIPDSVLREVDKVVVVACGTAYHAGLIAKYAIEHWTRIPCETELASEFRYRDPILDQRTLVIAISQSGETMDTLMALRHAREQGAKVLAVCNTNGSTIPRESDAVLYTHAGPEVAVASTKAFLTQLVACYLVALYLGQVRGTKWGDEVGSVVRELSEIAREVEEVLETMEPVRELARSLADKNTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEQDLPVVVVVPSPRGRSVLHDKIVSNIQEIRARGARTIVIAERGDEAVRPYADHLIEIPRTPVLLQPLVATVPLQVFACELATARGNEVDQPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ0</accession>
    <name>A0A2G1XIJ0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="12" type="ORF">BLA24_14800</name>
        <name evidence="13" type="ORF">CYQ11_13270</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51046">
        <property type="protein sequence ID" value="PHQ51046"/>
        <property type="gene ID" value="BLA24_14800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13731">
        <property type="protein sequence ID" value="PPT13731"/>
        <property type="gene ID" value="CYQ11_13270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="20378" checksum="3CF4B1C446D612C5" modified="2018-01-31" version="1">MAGPQRRGSGAGGGERRDRKGRDGGAAAEKTAYVERVVAINRVAKVVKGGRRFSFTALVVVGDGDGTVGVGYGKAKEVPAAIAKGVEEAKKNFFKVPRIQGTVPHPIQGEKAAGVVMLKPASPGTGVIAGGPVRAVLECAGIHDILSKSLGSSNPINIVHATVEALQGLQRPEEIAARRGLPLEDVAPAALLRARAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIQ4</accession>
    <name>A0A2G1XIQ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (Adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tsaB</name>
        <name evidence="2" type="ORF">BLA24_14990</name>
        <name evidence="3" type="ORF">CYQ11_13080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51080">
        <property type="protein sequence ID" value="PHQ51080"/>
        <property type="gene ID" value="BLA24_14990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13697">
        <property type="protein sequence ID" value="PPT13697"/>
        <property type="gene ID" value="CYQ11_13080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="222" mass="22893" checksum="23B7834BA9ABC170" modified="2018-01-31" version="1">MLLLALDTATPAVTVALHDGETVVAESNEVDARRHGELLLPAVDRVLGEAGVTLDAVTGIVVGVGPGPYTGLRVGIVTAATFAAALSVPVHGLCSLDGVAYAAGQAGLEGEFVVATDARRKEVYWARYADARTRVTEPAVDRPAEVAGQVAGLPAVGAGAVLYPDSFPGVRAELPQHQSAAALAALAAEKLRTGGEFLPDQPLYLRRPDAQVPANYKVVTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIZ0</accession>
    <name>A0A2G1XIZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF348 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Resuscitation-promoting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_15805</name>
        <name evidence="6" type="ORF">CYQ11_12270</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51218">
        <property type="protein sequence ID" value="PHQ51218"/>
        <property type="gene ID" value="BLA24_15805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13558">
        <property type="protein sequence ID" value="PPT13558"/>
        <property type="gene ID" value="CYQ11_12270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="4">
        <location>
            <begin position="328"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="495" mass="52929" checksum="6FDE3C47EF20AA85" modified="2018-01-31" version="1">MSHAPGSPRAATGTPSFDPYAPHDPYGALPDPYAPYDGGAPYGTACENPYADAYGPPPHDPFGQPHLPRQTAGPGTPARDDAAGHHGPPEGTGGAPGTEGRAVTEEAVPTGRGAARRAAAADRRKRPTPRERPEALRRLLPQALVVAFLAGGTSAFVASDKSVQLSVDGKPRTLHTFADDVDELLDDEGMRVGEHDIVAPGPQHDLASGDRVIVRYGRPVTLTLDGERRQVWTTARTVDGALRQLGVRAEGAYLSASRSAPIGRTGLDLDVRTERTITFMADGSERTLRTNAATVREAIDQAGISLHGQDTTSVDPESFPRDGQTISVMRITADDEVREEPIPYATERREDPTLYKGTEVVAQQGEKGVERVTYALRTVNGVQQKPKKISSVVVRPPRTEIIRVGTKPRPTSVRGTEGLNWESLAQCEAGGRPGAVDPSGTYGGLYQFDTRTWHSLGGTGRPQDASAAEQTFRAKKLYVSRGASPWPVCGRKLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ47</accession>
    <name>A0A2G1XJ47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15765</name>
        <name evidence="2" type="ORF">CYQ11_12310</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51211">
        <property type="protein sequence ID" value="PHQ51211"/>
        <property type="gene ID" value="BLA24_15765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13565">
        <property type="protein sequence ID" value="PPT13565"/>
        <property type="gene ID" value="CYQ11_12310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="27479" checksum="0528D31FD4F369B5" modified="2018-01-31" version="1">MAPAAARFEGYAVLITGAGRGIGEAVARRLAAEGAAVLVTDADGPRARRAATRIRAAGLTAEALTCDVGDRDAVDAAVAHAVGRFGRLDVLVNNALSCHPDPPLVEDYPDEVWSRDVDITLTGAFRCVRAAMPHLAAAGGRGAVVNIGSVNGEQDFGNHAYSAAKAGLASLTRTLAGQCAPRGVRVNLIAPGTVRTPNWEGWEASLERAAAHYPLGRVGRPEDVAAAVAFLASEDAGWITGVTLPVDGGILVANLGLRGALRRGYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ66</accession>
    <name>A0A2G1XJ66_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">BLA24_15590</name>
        <name evidence="7" type="ORF">CYQ11_12485</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51179">
        <property type="protein sequence ID" value="PHQ51179"/>
        <property type="gene ID" value="BLA24_15590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13597">
        <property type="protein sequence ID" value="PPT13597"/>
        <property type="gene ID" value="CYQ11_12485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="32748" checksum="95392CD9D098A702" modified="2018-01-31" version="1">MTQSRPRITKAVIPAAGLGTRFLPATKATPKEMLPVVDKPAIQYVVEEAAHAGLSDVLMITGRNKRPLEDHFDRNYELEEALRRKGDASRLAKVQESSDLATMHYVRQGDPRGLGHAVLCAAPHVGDEPFAVLLGDDLIDERDPLLSYMVDVQRLHGGSVIALMEVDPSQVGLYGCAAVKPTDTENVVEVTGLVEKPDPAEAPSNYAVIGRYVLDPAIFDVLRETEPGRGGEIQLTDALQALAAEPALGGPVHGVVFKGRRYDTGDRGDYLRAIVRLACEREDLGPDFRAWLRSYVTEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJQ3</accession>
    <name>A0A2G1XJQ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13190</name>
        <name evidence="3" type="ORF">CYQ11_00910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51465">
        <property type="protein sequence ID" value="PHQ51465"/>
        <property type="gene ID" value="BLA24_13190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11648">
        <property type="protein sequence ID" value="PPT11648"/>
        <property type="gene ID" value="CYQ11_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="16863" checksum="829512C11C42D297" modified="2018-01-31" version="1">MEARLNPFTNPVLGKVFKHIIAAGKVLEGSTLPASTQELVKLRASQINGCGFCTDMHFKDAVHAGESAERLNLVAVWREATVFTDAERAALELAEEATRIADAAGGVPDEVWANAAKYYDEDQLGALVGVITLINAFNRGNVMLQMPAGDYQPGQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJR7</accession>
    <name>A0A2G1XJR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13755</name>
        <name evidence="3" type="ORF">CYQ11_01450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51450">
        <property type="protein sequence ID" value="PHQ51450"/>
        <property type="gene ID" value="BLA24_13755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16281">
        <property type="protein sequence ID" value="PPT16281"/>
        <property type="gene ID" value="CYQ11_01450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="338" mass="35715" checksum="6D68374FA3BC8EBC" modified="2018-01-31" version="1">MLGAPPAHADAPVPPPMADGFGLTQVGAPTGTATNFVITVSTPQVAGEHRIRVLLPKDYAADPTKRYPVFYFLHGASDNPGNPALAYPALTAAQSMITVIPDGGRRGWYTNWLDQKTAAGAQNWENFHINQVIPFIDANLRTLADKKDRAVGGLSMGGFGAMHYAQSHPGLFSQVVSLSGATDFSVNHLVMRGAVVATLTNVGAPLCGSSAPTCSLNFGPTVSSDAVFGSPYPVFNADWRWNAVDPSSHANVSALAGMGIALYTGDGNGAAAEPEFWVESAARHVKDRLDALKFPYHYVDYGNGAGWGSDCKGGHTYGCWAQDLVDYVPRLEAAFASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJW1</accession>
    <name>A0A2G1XJW1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF899 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13535</name>
        <name evidence="2" type="ORF">CYQ11_01255</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51523">
        <property type="protein sequence ID" value="PHQ51523"/>
        <property type="gene ID" value="BLA24_13535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11706">
        <property type="protein sequence ID" value="PPT11706"/>
        <property type="gene ID" value="CYQ11_01255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="27523" checksum="D4A5ECE32A5326B1" modified="2018-01-31" version="1">MKTPPIVSPQEWEAARERLLGEEKELTRARDALAAKRRRMPWTAVDKEYAFEGPEGGASLLDLFGGHRQLIVYRAFFEPGVFGWPDHACRGCSMVADHVGHLAHLRARDTTLVFASRAPQPDIERVKARMGWTMPWYTMTDGFDADFGVDEWHGTNAFIRDGDKVFRTYFVNARGDEALGNTWSYLDMTALGRQETWEDSPEGYPQTPPYEWWNWHDAYGDAEPAPEWTAQTRRGPRGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJX6</accession>
    <name>A0A2G1XJX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000144">
        <property type="protein sequence ID" value="PHQ51548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51548">
        <property type="protein sequence ID" value="PHQ51548"/>
        <property type="gene ID" value="BLA24_13120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="108" mass="10896" checksum="676EA82E5E7297A1" modified="2018-01-31" version="1">MYGQGAGYRVRRLHQKAPAPARRARAAPAAAIHHPPPSCPGSAWGRVAGFSGEVLRSGTGGPAAVGDERGAGSAAGSTVSSFSPRPRAGKPTSTVTFHWPAGRVSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJZ3</accession>
    <name>A0A2G1XJZ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12800</name>
        <name evidence="3" type="ORF">CYQ11_17155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51574">
        <property type="protein sequence ID" value="PHQ51574"/>
        <property type="gene ID" value="BLA24_12800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14366">
        <property type="protein sequence ID" value="PPT14366"/>
        <property type="gene ID" value="CYQ11_17155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="131" mass="14593" checksum="CA154C26EE89458C" modified="2018-01-31" version="1">MASLNVGNLGEYLREQRRTAQLTLRQLADAAGVSNPYLSQIERGLRKPSAEILQQLAKALRISAETLYVQAGILDERDRDEAEVRSVILADPSINERQKQVLLQIYESFRKENGIAVDEAGKKDDPSKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKB7</accession>
    <name>A0A2G1XKB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase PAP2 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11305</name>
        <name evidence="3" type="ORF">CYQ11_02540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51677">
        <property type="protein sequence ID" value="PHQ51677"/>
        <property type="gene ID" value="BLA24_11305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11926">
        <property type="protein sequence ID" value="PPT11926"/>
        <property type="gene ID" value="CYQ11_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="238"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="482" mass="50589" checksum="669EEDB3338A7A00" modified="2018-01-31" version="1">MRTMVSSWDRSLFQQVAARHWPGGDRVLPKLSRGADHGVLWFGVATGAALLGGRSARRAALRGVASLAVASATVNTLGKRSVRRVRPVLDVVPTIRHLARQPFTTSFPSGHAASAAAFTTGVALENPAWGLALVPLAASVCFSRVYTGVHYPGDVVAGALLGVGAAFAVRGVAPTRSQLAPPARPRAEAPALPGGRGLVVVVSRGSGQRAASRPDPVPGIRAVLPDAKIVECSEGDSPADVLERAAAAAGGGALGVFGGDGTVNAAAAVARRHGLPLAVLPGGTYNHFAHDLGIESVADTARAVETGEAVAVDLVRVDGLRFLNTFSIGAYPDLVRVRERWAHRIGAWPAGVLAAVHVLRTAQPVPVRVDGRKRRLWMLFAGNCVYRGLGVAPVRRHDLADGVLDVRMIRGGRLARTRLLTAALTGGLRHSPVLRTARVRRLRVEDVPAGTHMAYDGEVAPAPRSLTLEKENEALVVYRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKG9</accession>
    <name>A0A2G1XKG9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11640</name>
        <name evidence="5" type="ORF">CYQ11_02880</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51735">
        <property type="protein sequence ID" value="PHQ51735"/>
        <property type="gene ID" value="BLA24_11640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11983">
        <property type="protein sequence ID" value="PPT11983"/>
        <property type="gene ID" value="CYQ11_02880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="481" mass="50776" checksum="03C9F31309D6B0D2" modified="2018-01-31" version="1">MVNQGDGPHGGIRGGGAAEGLGGDLHLELSDGPGGRRGALIRALRDAVRTGRLAPGTRLPPYRSLAADLGLARNTVAEAYAELVAEGWLTARQGSGTRVAARAEPPRPVRPPGTLTPPLPRRPRYDLVQGAPDAASFPRAAWLASTRRALTAAPNEAFGPGDPRGRPELRRAVADYLTRARGVRAEPDRVVICPGFAGALRLLGRVLSGTIAVESYGLGFHRSLLADAGLGTVVLPIDEHGARVEELAATGAGAVLLTPAHQFPTGGSLHAERRAAVVDWARATGGLVLEDDYDGEFRYDRQPVGAVQGLDPERVVYVGSVSKSLSPALRVGWMVLPAHLVDAVLAAKGERESWTSALDQLALADFIACGSYDRHVRRMRRHYRRRRDRLLTVLAERAPHVRVTGIAAGLHAVLELPPGTERTVVQGAAWQGLAVEALGPYRHGEATGVPGDGLVVGYGTPPEHAFSGALDALCQALPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL2</accession>
    <name>A0A2G1XKL2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11900</name>
        <name evidence="2" type="ORF">CYQ11_03140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51778">
        <property type="protein sequence ID" value="PHQ51778"/>
        <property type="gene ID" value="BLA24_11900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12025">
        <property type="protein sequence ID" value="PPT12025"/>
        <property type="gene ID" value="CYQ11_03140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="173" mass="19187" checksum="18FBDF82277A91AA" modified="2018-01-31" version="1">MRYADGPSVHEEVHIDAAPGRVWHLVTDIGLPARLSPELQRTGWLDGATAPEPGARFEGYNRHPLVGEWRTISRVVELEPERRFCWEVTDPDGRYGGDPDEPLATWMFELKPEGDGVLLRQSVRVGPGRSGASLAIDRAPEKEEAIVEMRLGELRTGIQATLRGVREIAEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL6</accession>
    <name>A0A2G1XKL6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11860</name>
        <name evidence="4" type="ORF">CYQ11_03100</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51772">
        <property type="protein sequence ID" value="PHQ51772"/>
        <property type="gene ID" value="BLA24_11860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12019">
        <property type="protein sequence ID" value="PPT12019"/>
        <property type="gene ID" value="CYQ11_03100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="248"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="555" mass="60657" checksum="007AD1CCCDC1925F" modified="2018-01-31" version="1">MAASPAKPRRLSPERCDRNTLSRPSHGANGERRRRPPAVSIPAREPGHFTGKVYLDVSELLTELARPATAAELANLYSALDGQGLVPDTVVPSVVVVEAPGSPTLVPGLTERLGPFGVKVIALPAPASSTPARTTFLLGGELHGWCLESPAGDDPARDEESDEAELIGSAVVAARLRAWAAATRPVPTVTRFHRPGSDSIGVVQFDAGAETELVAKIGEAGMIRSETGFTSRTNDDLARIGRDPLFPRLHGVHIEGHQGVSIMEAAEAADLEQRLFSDEDRTEPAPDAADVLAPYLDQLGRWYRLTAGGTRPTSADYLYRERFHALREQPAFRSTFRLCFGDRDLDEHLAADLVLPDGSRIPGYTAATAWLDEHAPALLPRTGSQVHGDIYPTNMLRRSGGGPVFIDPRTVWEQRQRPDVGYGDPVFDLATLLHGLLPMPAILHAARQGKPEALFGDAFDPARPHDVSALRLPLRFSDRLRSMEHRLIETAPGDEPAHTVRCRLYIGAACSLAGWLKYENTLRTPQVWTATYAYTAWYLWQARTVHEQHTTKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKN1</accession>
    <name>A0A2G1XKN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12090</name>
        <name evidence="2" type="ORF">CYQ11_03330</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51814">
        <property type="protein sequence ID" value="PHQ51814"/>
        <property type="gene ID" value="BLA24_12090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12060">
        <property type="protein sequence ID" value="PPT12060"/>
        <property type="gene ID" value="CYQ11_03330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="388" mass="41076" checksum="5EE01E1423A2CF25" modified="2018-01-31" version="1">MSKEPVAVVGIGQTHHAAARRDVSLAGLVREAARRALADAELTWSDIEAVVLGKAPDFFEGVMMPELYLADALGAAGKPVLRVHTAGSVGGSTALVAANLVAARVHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYIRRSGAPGGVGALVALKDRRNALNNPYAHLHEHDITLEKVRSSPMLWDPIRYSETCPSSDGACAMVLTDRAGAARAPHPPAWLHGGAMRSEPTLFPGKDFVSPRAGRDCAADVYRQAGITDPRREIDVVEMYVPFSWYEPMWLENLGFAAEGEGWRLTESGATGPGGDLPVNPSGGVLSTNPIGASGMLRFAEAALQVRGAAGEHQVPGARRALGHAYGGGAQFFSMWLVAAQPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKQ4</accession>
    <name>A0A2G1XKQ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12100</name>
        <name evidence="4" type="ORF">CYQ11_03340</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51815">
        <property type="protein sequence ID" value="PHQ51815"/>
        <property type="gene ID" value="BLA24_12100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12062">
        <property type="protein sequence ID" value="PPT12062"/>
        <property type="gene ID" value="CYQ11_03340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="35014" checksum="E5DA900AACC9180E" modified="2018-01-31" version="1">MPEPLSAPMVVAFPFTRSLGPVQSAFLTGLRERTVLGVRTHDDRVLVPPVEYDPRTAEEIRDLVEVDPTGTVTTWAWNPAPRRGQPLTHPFAWALVRLDGADTALLHALDAPGPDAVRTGLRVRVRWAERREGAITDIACFEPYEHPTAVRPARPHDGVFPDPVTGIIAPARLDYTYSPGRAQTRHLRALAAHRVLGERCPSCHKVCVPPRGACPTCGVATTEPAEVGPRGTVTTFCVVNIKAKNTGHAEGTAVDVPYVYAHIALDGADLALHGRIAGIPYDQVRMGLRVEPVWTDGGRYPDHYRPTGEPDADYDTYKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU9</accession>
    <name>A0A2G1XKU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11395</name>
        <name evidence="4" type="ORF">CYQ11_02630</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51846">
        <property type="protein sequence ID" value="PHQ51846"/>
        <property type="gene ID" value="BLA24_11395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16310">
        <property type="protein sequence ID" value="PPT16310"/>
        <property type="gene ID" value="CYQ11_02630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="2">
        <location>
            <begin position="54"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="465" mass="49020" checksum="F26418DD460E3EB5" modified="2018-01-31" version="1">MALPAGASLPSLPAHPDPRLDEAAASGLLHELAHAFGGPFHLLVPERLDANAAAFRAALAEAGVTGRVYYAKKANKAAAFVERCAATGTGVDVASAGELREALGHGVRGEDLVVTGPAKDPALLRVAVLQGALIAVDALDELDRIVEVARAGPARPARVLLRRLPPTQPHSRFGLDEAELDKALARCAEAGPLVRMEGFSFHLSGYAVQPRADLAGQLVEQCLRARTMGLPADRVSIGGGFAVDYAAADDWHTFLATQRPAHYHAGKTFTAGDFYPYHSPVAGAAALRAVLATRPDGGGVTLAARLRETGTELLLEPGRALLDGAGHSVFRVQGVKDRAGYALVTVDGTSLSLSEQWFASEYLPEPRLVRAPDRSGGRQAGAGEVHPASVGAATCLESDMLSWRKIPFPARPAPGDLLVYPNTAGYQMDSNESPFHDLPLPPKAVLEPAAAGGRPRWRLDRRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKX1</accession>
    <name>A0A2G1XKX1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Threonine/serine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11955</name>
        <name evidence="5" type="ORF">CYQ11_03195</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51789">
        <property type="protein sequence ID" value="PHQ51789"/>
        <property type="gene ID" value="BLA24_11955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12035">
        <property type="protein sequence ID" value="PPT12035"/>
        <property type="gene ID" value="CYQ11_03195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="32321" checksum="16CC89CD32C705D0" modified="2018-01-31" version="1">MHRLTYDDVKRAADRVAGHVRPVTVTAAAPGLWLALEHMQHTGSFKARGARNFLAAHQEDGTLPAAGVTIASGGNAGLACAWAARAQGVRATVFLPENAPHVKVAKLRSYGADVRLVGTEYAQALAACEEFARTTGALPSHAYDHPLIAAGAGTLLDEVRERVPGLDTVVVAVGGGGLFAGVATAARHHGVRTVAVEPENCRALNAALDAGRVVDVTVDSVAADALGARRVSADALALARDGGVRSVLVPDDEIVRTRQTLWDDRRLAVEHAAATALAALAGGERAAYVPAAGERVAVVVCGANTDPSDLVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKZ6</accession>
    <name>A0A2G1XKZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_11040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000131">
        <property type="protein sequence ID" value="PHQ51900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51900">
        <property type="protein sequence ID" value="PHQ51900"/>
        <property type="gene ID" value="BLA24_11040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="233" mass="25521" checksum="2CD19EE5E036654F" modified="2018-01-31" version="1">MADTHVLFVEDDDVIREATQLALERDGFMVTAVPDGLLGLESFRARRPDIALLDVMVPGLDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGAVLVARIRAVLRRFGHASGANGAADGTPETIEGGTLRFGDLEVDTEGMEVRKAGPRRPHPTEMRLLLEFSAAPGTVLSRDRLLERVWDYGWGGDTRVVDVHVQRLRGKIGQDRIETVRGFGYKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL26</accession>
    <name>A0A2G1XL26_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ORF">BLA24_10865</name>
        <name evidence="6" type="ORF">CYQ11_00685</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51943">
        <property type="protein sequence ID" value="PHQ51943"/>
        <property type="gene ID" value="BLA24_10865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11613">
        <property type="protein sequence ID" value="PPT11613"/>
        <property type="gene ID" value="CYQ11_00685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="38729" checksum="43EC13FDE359E035" modified="2018-01-31" version="1">MTGPATARVAPRLSFLDRCLPVWILAAMGAGLGLGRLVPGLGDGLAKVTVTGVSLPIALGLLVMMYPVLAKVRYDHLGTVTRDHRLLTPSLLLNWVLGPAMMFALAWLFLPDLPEYRTGLVIVGLARCIAMVIIWNDLAGGDREAAAVLVALNSVFQVIAFAGLGWFYLSVLPGWLGLDQTALDVSVWEIAQSVLIFLGIPLLAGYLTRRLGEKAKGRSWYEATLIPRIGPFALYGLLFTIVVLFALQGDAIASQPLDVARIALPLLVYFALMWAGSMALGRAAGLDHPRATTLAFTAAGNNFELAIAVAIATFGASSGQALAGVVGPLIEVPVLIGLVYVALAARRFFPPLADAPSAPVPEGSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL29</accession>
    <name>A0A2G1XL29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11125</name>
        <name evidence="3" type="ORF">CYQ11_16840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51881">
        <property type="protein sequence ID" value="PHQ51881"/>
        <property type="gene ID" value="BLA24_11125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14310">
        <property type="protein sequence ID" value="PPT14310"/>
        <property type="gene ID" value="CYQ11_16840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="131" mass="14822" checksum="11BDB2D2218AE04D" modified="2018-01-31" version="1">MVRRLGELEDAVMTRVWEWNRPVTVREVLEDLQQERSIAYTTVMTVMDNLYQKGWLRREAEGRAYRYEAVSNRAAYSAALMNEAWSLSDNPAAALVAFFGMMSAEQREALRDAIRVAQLDGPGEPPGAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLJ7</accession>
    <name>A0A2G1XLJ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09320</name>
        <name evidence="2" type="ORF">CYQ11_27930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52112">
        <property type="protein sequence ID" value="PHQ52112"/>
        <property type="gene ID" value="BLA24_09320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16192">
        <property type="protein sequence ID" value="PPT16192"/>
        <property type="gene ID" value="CYQ11_27930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="95" mass="10221" checksum="1FE4360432C0581C" modified="2018-01-31" version="1">MSTARVWSIERIRDALGSPDLSQRFLGEICRAPADEVLAVFTKWQGIAERTLAAVERGRQAAAAEAAGGEVPGEWIDITQKVQEDAALVRSRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLP6</accession>
    <name>A0A2G1XLP6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-hydroxylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09615</name>
        <name evidence="3" type="ORF">CYQ11_28225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52163">
        <property type="protein sequence ID" value="PHQ52163"/>
        <property type="gene ID" value="BLA24_09615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16244">
        <property type="protein sequence ID" value="PPT16244"/>
        <property type="gene ID" value="CYQ11_28225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041141">
        <property type="entry name" value="CmlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18456">
        <property type="entry name" value="CmlA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CmlA_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="527" mass="58388" checksum="06FC1DF23890A415" modified="2018-01-31" version="1">MQGGEKFLKSRVIIEPLVDRFYAWFHTVAPVQASMNLARLQVPLLESYLQSPESHVVASNNPDLRGGYFVNIPEERSDEVRELLDSIRKERAGMLEFAAAVAEAEELLRQNATGFDLTPLYPKLPKALSGLVELAYDTGNQASVRFVEPLAYHSPAYTEERQSVQLSLEPGVERPFILSTPRLPAPDVLELAVPFRHQGLADLFRARIRPTTEAALREALELDDAQAALLPGLLADEPAGSPDRHIDAGGRIRYFGHACLLLQSPGAAILTDPFISADGSHGDRFTYDDLPDHIDLVLITHGHQDHIVLETLLQLRGRVGAVVVPRASRGNLVDPSVGLYLRHLGLPVVEVDDFDEVPFPGGEVVATPFLGEHCDLDIRAKSTYWVRLAGKSVYVGADSSGIDPGLYRYVREHLGTADMAFLGMECDGAPLTWLYRALLTRPVPKKMSGSRKLSGSDAAQAAAIMTEFGAREAYVYAMGEEEWLGHVMATTYDEDTYQLQQIDEFLTWCADRGIPAEHLLNKREWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY1</accession>
    <name>A0A2G1XLY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08825</name>
        <name evidence="4" type="ORF">CYQ11_04085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52252">
        <property type="protein sequence ID" value="PHQ52252"/>
        <property type="gene ID" value="BLA24_08825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12185">
        <property type="protein sequence ID" value="PPT12185"/>
        <property type="gene ID" value="CYQ11_04085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="393" mass="40951" checksum="5A429F3A3466256C" modified="2018-01-31" version="1">MEQPRAVVVGAGIGGLTAAVALHRRGWRTVVLERAASLEPVGAGISLAPNSQRALDVIGLGDEVRALAAWQGDGGLRSPSGRWLSRTDSAAAARRFGGPLVLLHRATLAGLLAGALPDGTVRTGRPATLADPGGPDRPARVTTPDGDLEADLVVGADGINSPARRMLFPAHPGPVHTGFTTWRVVTPAPERPFAPHETWGTAGLWGTHPLKDGRVYAYASAAAPAGSRAHDDERAELLRRFGTWHHPVPDVLAAADPAGILRNDVHFMAEPLPAFHRGRTALLGDAAHAMPPNLGQGGNQAVEDAVVLAHHAAPVPGGVPAALAAYTHDRLPRTAEVVRRSARTARMALLSGAPAVALRDTAIATVSRLAPGLLLRGFDGIADWRPPVRTYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMB7</accession>
    <name>A0A2G1XMB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07985</name>
        <name evidence="4" type="ORF">CYQ11_00420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52378">
        <property type="protein sequence ID" value="PHQ52378"/>
        <property type="gene ID" value="BLA24_07985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11580">
        <property type="protein sequence ID" value="PPT11580"/>
        <property type="gene ID" value="CYQ11_00420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="21058" checksum="1EFD88D41BE9BF9A" modified="2018-01-31" version="1">MNADTPAKRPGGRSARVQAAVHQAVTDLARERETAQLTIPAVAERAGVNPTTIYRRWGTLQALLAEVATLHTADAPPPSSGDLRTDLEAYAIRTLADLTRPGGIAFFRAEVAPDIDERRSGLRECLHRATVGLEAVLEASRGRGETPPSTERLLDRIVAPLYFRVVFSMPDTDETYARALVTDLFSDPSQPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMF8</accession>
    <name>A0A2G1XMF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07815</name>
        <name evidence="3" type="ORF">CYQ11_00250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52351">
        <property type="protein sequence ID" value="PHQ52351"/>
        <property type="gene ID" value="BLA24_07815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11553">
        <property type="protein sequence ID" value="PPT11553"/>
        <property type="gene ID" value="CYQ11_00250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="99" mass="11269" checksum="DAF0C6C08544B024" modified="2018-01-31" version="1">MPDVTVHHPATSPARHATSYRMNARNRAWLARRNLPRILIPANLAVWILLTLWRFRGLKVLLTSLAGFREGLRTNCGTRTPMSWRTIAQLTLAGRPPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMN1</accession>
    <name>A0A2G1XMN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06495</name>
        <name evidence="3" type="ORF">CYQ11_26645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52431">
        <property type="protein sequence ID" value="PHQ52431"/>
        <property type="gene ID" value="BLA24_06495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15963">
        <property type="protein sequence ID" value="PPT15963"/>
        <property type="gene ID" value="CYQ11_26645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="555" mass="59748" checksum="C29BA69FD4062242" modified="2018-01-31" version="1">MLKSSPYVRRWALVVAVVSVTAAVAQQLLIIAGFGGWLPGWQPWPCLLLAVPSFLIALRSGATVACPAPLLKGAEVIRRVPVGVCVLGVLVLTAFVWASLQEHEPHFGHEEAVYANKARSWLEGTPDAGWGLYRPVGLPALGYVALTVHNSVGTLRVVALCVVLFTLTVTYVVAARWTTPRRAVVVTLLLLGGLGFLRRVPEFLNDIGSTGLLLMVVFLVALAQEKPRSRAVLGLPFVIVPAFYFRYGVVGNLLAVFLAALVAYGPRAWAAQWRRLLWAVLLVALGLVPHLVHAVRATGSPLGVMTRATSQANRAFFGDGLLYYAATFPYRLAGDLGAVVMVAGILALVAAVRRVRSAGPSTIERSEDRRRVFLGLTALFMFVVLGCTSHGEPRFVYVPVVLLTVLGVQNLAERSGRWSAQTLTAVGVLASLSVLVTAQVVGHGAMRGPSRLSESTVPVARSLTSDRPCLVVSGYEPEMGWYSGCDAVTYAQYEERAVPPDMRVTLVLFERGRLQPGPTAVKELVGDREVTTSVRDTDGSLGTARAITFREGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMU2</accession>
    <name>A0A2G1XMU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWF or SNF family helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07185</name>
        <name evidence="3" type="ORF">CYQ11_27340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52548">
        <property type="protein sequence ID" value="PHQ52548"/>
        <property type="gene ID" value="BLA24_07185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16086">
        <property type="protein sequence ID" value="PPT16086"/>
        <property type="gene ID" value="CYQ11_27340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="44336" checksum="3F5E170873A7806F" modified="2018-01-31" version="1">MTSVNEHDEHDERTFAALPPVQGRGFAQSEWGRAWLAALEDSALDGQQVKAGRRHARAGAVGAVTVRPGRITALVRDRDGTAQRSDVVVQRLSAADWDRLLDLVAGRAGHVAALLDRALPPHLAEDAAAAGVDLLPGIGDLEPECACGAWDHCPHTAALCHQVARLLDEDPFVLLLIRGRGERELRRELEARGTAGTTAHARQAPAGVPAREVFAAHAVVRELPAPPPAVEAPGRAPVLAGASAEPPGLDVPALEFLVTAAAARAHQMLSEALAPGHEETPVPVELTVRQDAVRLAAAGPPGRVADRLAAGCGHGRAELAQAVRAWGHGGPAALAVLDEDGEPEPADLARARARLAGAWEQGEAPRLRAVRNRWTVVGTGAQLRYGPDGRWWPYRKEGGRWQPAGPGDHDPAAALAGVLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN01</accession>
    <name>A0A2G1XN01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07200</name>
        <name evidence="3" type="ORF">CYQ11_27355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52551">
        <property type="protein sequence ID" value="PHQ52551"/>
        <property type="gene ID" value="BLA24_07200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16089">
        <property type="protein sequence ID" value="PPT16089"/>
        <property type="gene ID" value="CYQ11_27355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="60" mass="6596" checksum="B1058F0F6BE5A272" modified="2018-01-31" version="1">MTNRTKVAVGGVAVGVVLLWLLPFWAALLVLIGVPVGAYLLLDPSQRKRLRRASRKELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN39</accession>
    <name>A0A2G1XN39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07430</name>
        <name evidence="3" type="ORF">CYQ11_27580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52591">
        <property type="protein sequence ID" value="PHQ52591"/>
        <property type="gene ID" value="BLA24_07430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16128">
        <property type="protein sequence ID" value="PPT16128"/>
        <property type="gene ID" value="CYQ11_27580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="190" mass="20713" checksum="A6B1FA0CC5005839" modified="2018-01-31" version="1">MTDLDQLTQSLARNLKRWRNERNFTLDALAARSGVSRGMIIQIEQARTNPSVGTTVKLADALGVSITTLLDYEQGTRVRLVSPEQVVRMWSTEAGSHTSLLVGADARGPLELWEWRLVPGDSSASDPHPPGTVEMLRVTAGELTLVVDGEEHRLAAGTSATFDADVPHTYRNDGDRPVEMTMVVAVPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN59</accession>
    <name>A0A2G1XN59_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_06145</name>
        <name evidence="9" type="ORF">CYQ11_03670</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52682">
        <property type="protein sequence ID" value="PHQ52682"/>
        <property type="gene ID" value="BLA24_06145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12116">
        <property type="protein sequence ID" value="PPT12116"/>
        <property type="gene ID" value="CYQ11_03670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="22498" checksum="CF69A274D8133FE7" modified="2018-01-31" version="1">MHVLLDNVDLFRRGFLGTLALTGLSTFLALTLGTVLTVFRVCPVPPLRVFGAAGVTVLCNTPLTLLFFGVTLGLPMVGLSGMGYFTLAVLTLGGYSSAFVCEALRSGVNTVDVGQAEAARSLGMSFAQTAFLVVLPQAGRVAVPPVGSILITLTKNSALAGGFSVYELFSVEKTLAEQGYAILTVFAWVSVAYLLLILTISGAVRLVEHRLAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN78</accession>
    <name>A0A2G1XN78_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05335</name>
        <name evidence="5" type="ORF">CYQ11_01795</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52702">
        <property type="protein sequence ID" value="PHQ52702"/>
        <property type="gene ID" value="BLA24_05335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11795">
        <property type="protein sequence ID" value="PPT11795"/>
        <property type="gene ID" value="CYQ11_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304980" evidence="2">
        <location>
            <begin position="43"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="164"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="24744" checksum="3674D0F4860DB56C" modified="2018-01-31" version="1">MRSTHSGYTRLSKVHKVSAAGLTAAAAATVVFAAVSGGTASAAEAHAVKPVAWSAGSFGETQQDELSTYADAAAAKAKAEAAAKVKAAAKADAAAKAKADQERASRSEARKPMKPAAAKPAAKPAAPAKKAYADNLDGWIRQSLDILHAKGVPASYEGIKRNVMRESTGNPRAINDWDVNAVNGVPSKGLLQIIDPTFKAYHVEGTSWDIWDPVANITASCNYAADKYGSMDNVNSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN94</accession>
    <name>A0A2G1XN94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylaspartate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06095</name>
        <name evidence="2" type="ORF">CYQ11_03620</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52698">
        <property type="protein sequence ID" value="PHQ52698"/>
        <property type="gene ID" value="BLA24_06095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16331">
        <property type="protein sequence ID" value="PPT16331"/>
        <property type="gene ID" value="CYQ11_03620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006396">
        <property type="entry name" value="Glu_mut_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06368">
        <property type="entry name" value="Met_asp_mut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001495">
        <property type="entry name" value="Met_asp_mut_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="439" mass="47192" checksum="0B777E5B7875707C" modified="2018-01-31" version="1">MPRSLFGDFVARSSAAGRLVVQPRMGFGDPGVMRAGLVDVHRADATSIGTITLDSYTRVGELDAARQALAEGADLNGYPIVVHGTPTNKAVVEGLLGRDFPIQVRHGSARPQDIIASSLRAGLDATEGGPVSYCLPYGRISLRDSVRNWEESCRLMTDSRGPGCEPHVETFGGCMLGQLCPPSLLVAISLLEGLFFRWHGVRSISLSYAQQTNAEQDCGAVRALRRLARLFMPDVDWHVVVYTYMGVYPRTASGARLLLEQSVDIAVRTGAERLIVKTAAEAHRIASVADNIEALEAAADADRQARAAGLAAAADAETADDADTLEVFDESLSIVTTILGLHEDPGAALQEAFARGLLDVPYCLHADNMGRTRSYIAPDGRLRWSDTGALPIRTAGRTAETGRMTASDLLDALSCVQRSFDHAAVRHARQPGRRVHLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNC3</accession>
    <name>A0A2G1XNC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05490</name>
        <name evidence="3" type="ORF">CYQ11_01950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52728">
        <property type="protein sequence ID" value="PHQ52728"/>
        <property type="gene ID" value="BLA24_05490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11822">
        <property type="protein sequence ID" value="PPT11822"/>
        <property type="gene ID" value="CYQ11_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045428">
        <property type="entry name" value="EACC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19953">
        <property type="entry name" value="EACC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="99" mass="11114" checksum="5E53DCA29AD12722" modified="2018-01-31" version="1">MSGHVEERDVKSLETWLKDEPELKGRVQVKRGARRGEAGVPMGPQLDIVLHVIDWGGAAASAEIVRRVAESVKEWRTSRRALGDPDPPDFRAERDDEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XND1</accession>
    <name>A0A2G1XND1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_05445</name>
        <name evidence="6" type="ORF">CYQ11_01905</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52720">
        <property type="protein sequence ID" value="PHQ52720"/>
        <property type="gene ID" value="BLA24_05445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11814">
        <property type="protein sequence ID" value="PPT11814"/>
        <property type="gene ID" value="CYQ11_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="227" mass="23518" checksum="C40910316A539D80" modified="2018-01-31" version="1">MIRVLLADDEPMIRVGIRAVLSTDPGLEVVAEAGDGHEAVELVRRHRPDVAVLDIRMPRVNGIEAAARIRAAVPGTGVVMLTTFGEDDYILQALSGGAAGFLVKSGAPEELLAGVRAVAEGAAYLSPKVAARVVAHLSATGAGSATARRAAARERIASLTPRERDVLSHLGAGLSNGQIARRLHLVEGTVKAHVSSILSRLGVDNRAAAAVVAHEAGVLPPPVQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNG4</accession>
    <name>A0A2G1XNG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05890</name>
        <name evidence="4" type="ORF">CYQ11_02365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52792">
        <property type="protein sequence ID" value="PHQ52792"/>
        <property type="gene ID" value="BLA24_05890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11894">
        <property type="protein sequence ID" value="PPT11894"/>
        <property type="gene ID" value="CYQ11_02365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="97" mass="10840" checksum="FC784D96BFFBBC39" modified="2018-01-31" version="1">MTEPTTVDEAGVLAEITDVLRRVLDDLELEDIPVTPDTRFVEDLDLESIDLVTLTAELRARYGERVDFPAFFASLELSEIIGLTVGRLVRHIVGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH5</accession>
    <name>A0A2G1XNH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XshC-Cox1-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05515</name>
        <name evidence="5" type="ORF">CYQ11_01975</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52731">
        <property type="protein sequence ID" value="PHQ52731"/>
        <property type="gene ID" value="BLA24_05515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11826">
        <property type="protein sequence ID" value="PPT11826"/>
        <property type="gene ID" value="CYQ11_01975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="3">
        <location>
            <begin position="206"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="404" mass="41958" checksum="E9522338ABC23E1E" modified="2018-01-31" version="1">MLDIAPELSRWCAQGRDFAVATVVATQGSAPRRPGAALAVDADGTVTGSVSGGCVEAAVYELCRQALTSGTSVLERFGHDADDPFAAGLSCGGAIDVLVTPVPAGTPDADTLADALTAAARGEAVALVRGLDSPAGLLGRVLLVRPDGTGRGSLGGDARLDGAAAEEARALLGAGRTSTVRLGHDGSRCGETTTLLIETAAPPPRLVVFGAVDFASALVRVGEFLGFHVTVCDARAVFATRERFPRADEVVVDWPHRYLDSQRLDGRAALCVLTHDARFDVPLLERALRLPVAYVGAMGSRRTHHERLRRLREAGLTEAELARLRSPIGLDLGARTPEETALSIASEIVAERHGGTGRPLTGLCAPIHRDPSPGRPVRAGLPAVDGSGAGHPPRRVRATGPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH8</accession>
    <name>A0A2G1XNH8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05870</name>
        <name evidence="2" type="ORF">CYQ11_02345</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52788">
        <property type="protein sequence ID" value="PHQ52788"/>
        <property type="gene ID" value="BLA24_05870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11890">
        <property type="protein sequence ID" value="PPT11890"/>
        <property type="gene ID" value="CYQ11_02345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="13750" checksum="275A4C545A3B144F" modified="2018-01-31" version="1">MPFIRVTVSDPGLVPATQQALADGLTALAVSALGKSAGRTTVHVLLTPPGRFFVAGRPMAECTGAHVEASITAGTNSADEKGRFITGAYELLRETLGVLPPVAGVALYELHPESYGYNGITQLEHYRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNQ0</accession>
    <name>A0A2G1XNQ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04730</name>
        <name evidence="2" type="ORF">CYQ11_28805</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52874">
        <property type="protein sequence ID" value="PHQ52874"/>
        <property type="gene ID" value="BLA24_04730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11467">
        <property type="protein sequence ID" value="PPT11467"/>
        <property type="gene ID" value="CYQ11_28805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="99" mass="11141" checksum="21B25D246A329F3B" modified="2018-01-31" version="1">MSTSQPWTIDGIGHALPHPELRATFMREVSFTDVRELPAVLERWVAFIQTFEAERPRLEQLRELVHENGHPPATYTAGLIDVAPDELHSAADENRRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNV3</accession>
    <name>A0A2G1XNV3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05895</name>
        <name evidence="9" type="ORF">CYQ11_02370</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52829">
        <property type="protein sequence ID" value="PHQ52829"/>
        <property type="gene ID" value="BLA24_05895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16304">
        <property type="protein sequence ID" value="PPT16304"/>
        <property type="gene ID" value="CYQ11_02370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="7">
        <location>
            <begin position="546"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1352"/>
            <end position="1378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1414" mass="148893" checksum="BC404F95508FEBB4" modified="2018-01-31" version="1">MAVTLPGAGDLDTYWRNIVRGTDAISDVPPGRLDPDEVEGIHCRRGGFVDDVAGIDPAAFGIMPDSVATTEPDQLIALRTAAAAIADAGGALPRDRSRAGVVLGRGGYLTAGLARLDQRVRTCGQLLRTLREVMPELDGERLAQLRTAFLDALGPRGGEHGIGLVPNFAASRVANRLDLRGPAYTVDAACASSLVAVDQAAGELRAGRCDVMLAGGVHHCHDITLWSVFAQLRALSPTQRIRPFHREADGVLMGEGTGVVVLKRLRDAQRDGDRVYAVVRGVGVASDGRTASLVNPDPSGQARAVRLAWAAAGLDPALPGALGLLEAHGTGTPHGDRAEMAMMAEVFGGGDGPADAVVGSVKSMIGHTMPAAGAAGLIKAALAVHHGVLPPTLHCDDPHPALLATRFRPLAEARPWEADVRRAGVDAFGFGGINAHVVLEEPPAPAARRPARPAALDVAEPEPLLRLAAADQPALAVLLDADDAALRHSGEPGPGPARLAVAGPTAKRLALARKAVARGRPWGGRGDVWFAPGPLLGAAGGKTAFLFPGLEADFVPRVDDVARRFGLPRPGRQDARVGDVARHGAAVVGVGRLLTHALRRVGVTPDAVAGHSVGEWTAMVAGGMFADDEVDAFLRDFDPHALEVPGLAFAAFGAPAAQVRAALTDLDGVVLSHDNAPHQSVACGPDARVRALAARLRGEGVLGQVLPFESGFHTPMLAPHLGPIREQSLRFTLRPATVPVWSCTTAEPFPADESAVRELFVRHLLEPVRFRQLTEAMYAAGFRAFVQLGTGRLPSLVGDTLADRDHLAVAANSPRRSGLAQLAHVAAALWTAGAEPDFAALLGPRPGTRIDLGAGPVSLAPADRDRLRRTLRGPGGGASPLAAWAPGVPAAAELDALLTETASAAADVLAAAATAAPPVVSPAAPGPAVAPPLRTRVRVGVETMPYLLDHCFFPQRPGWPDLTDRWPVVPATTIAQHMTDAVAAAGTPVALRGARFLEWAVAAPPVDVDVTATAGSDGWYDVAFGRYARAEVRVADAYPAPPAPWPDPGPGIRPPLTAREMYDERWMFHGPLFRGVTAVTALGERHVRGVLTAPPAPGALLDNVGQLLGYWLMATHRERTVVFPVGFREAVFHGPHPGPGTALDCHIRITTLTDTTLEADAELARGHRVWARILGWQDRRFDSTPGTDAVHRRPDRRTLSTEQPGGWQLLFDRWPDPASRELTMRNQLAGEERTAYAAHPPRGRRQWLLGRIAAKDAVRRHLWDHGGGPVFPGEIRIHDDAAGRPRAGGRHGRRLPPLALSLAHSREAAVALVRPAGTPAGIGIEEVPEGEPADPGNTPLHRAAARAAAAAEGTALPADPRGTALARTGPDRLTARTPSGRTYTVRLTRTGNPPGLPPRTYVVAWTEENEEQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP22</accession>
    <name>A0A2G1XP22_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05245</name>
        <name evidence="9" type="ORF">CYQ11_28285</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52988">
        <property type="protein sequence ID" value="PHQ52988"/>
        <property type="gene ID" value="BLA24_05245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11500">
        <property type="protein sequence ID" value="PPT11500"/>
        <property type="gene ID" value="CYQ11_28285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="49932" checksum="28910E5B53463E70" modified="2018-01-31" version="1">MSAPVSVVLFTSDLRLHDHPPLRAALASAAEVVPLFVRDEGIDAAGFAVPNRRAFLADCLRDLDAGLRKRGGRLVVRSGDVVARVCEVVAESGAGAVHMAAGVSGYAQRREERLERALRARGCRLSVHDSVITALAPGAVTPAGSGHFAVFTPYFRRWSGERLRDVLGAPRAVPVPPGVRSEDLPSRADVPGTSPGLAAGGETAGRGRFAAWRRAGLARYGDRHDDLAGDATSRLSPHLHFGTLSPVELVRRAREAGGPGADAFVRQLAWRDFHHQVLAARPAAALADYRPRHDRWRTEESAREEVAAWKEGRTGYPVIDAAMRQLLHEGWMHNRGRLLVASFLTKTLYVDWRVGARHFLDLLVDGDVANNQLNWQWVAGTGTDTRPNRVLNPVAQAGRHDPEGAYVRRWVPELAGLAAPAVHAPWTLPAPERAAYDYPAPVVALSEGLARFKRARGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP85</accession>
    <name>A0A2G1XP85_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_03975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53047">
        <property type="protein sequence ID" value="PHQ53047"/>
        <property type="gene ID" value="BLA24_03975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ53047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="120" mass="13364" checksum="C07D6FD645A583F9" modified="2018-01-31" version="1" fragment="single">YRERRVDTLLAALDPYIRRDSSGRPRIDEHHRLILDPSVKGAVHVQNAETHTHGVGAPDLGLAAWRSAVILNALTGKTVYALPQRTAFTTFGLEPRPQPRPQTAIGSENRHTIPRQLPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPH0</accession>
    <name>A0A2G1XPH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03230</name>
        <name evidence="2" type="ORF">BLA24_16685</name>
        <name evidence="4" type="ORF">CYQ11_16600</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000038">
        <property type="protein sequence ID" value="PHQ53134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50476">
        <property type="protein sequence ID" value="PHQ50476"/>
        <property type="gene ID" value="BLA24_16685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53134">
        <property type="protein sequence ID" value="PHQ53134"/>
        <property type="gene ID" value="BLA24_03230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14269">
        <property type="protein sequence ID" value="PPT14269"/>
        <property type="gene ID" value="CYQ11_16600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="17239" checksum="14521783EF6DDC43" modified="2018-01-31" version="1">MLAPLWRGLSPIDSSADSNSVSCALPPRFEAVRTARRFTRSTLGQWDLGGLFDDVALVVSELVTNSMRYAIPADLIGTEYEPPVRLHLTRWASRLVCAVRDPSEVSPVTGEADAADECGRGLLLVESFSDAWGWHPLAGALHGKVVWALFRLPREHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPU2</accession>
    <name>A0A2G1XPU2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroQ</name>
        <name evidence="11" type="ORF">BLA24_02770</name>
        <name evidence="12" type="ORF">CYQ11_05065</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53254">
        <property type="protein sequence ID" value="PHQ53254"/>
        <property type="gene ID" value="BLA24_02770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12346">
        <property type="protein sequence ID" value="PPT12346"/>
        <property type="gene ID" value="CYQ11_05065"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="15888" checksum="37025F9E9C344DAC" modified="2018-01-31" version="1">MNGASGRRVLVLNGPNLGRLGSREPDVYGSTSYEGLVEACTALGTELGFAVEVRETNDEGELVRWLHEAADGALPVVINPGAFTHYSYAMRDAAAQRTAPLIEVHISNPYAREEFRHTSVIAAVASGTVAGFGIGSYRLALRALAEELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPV8</accession>
    <name>A0A2G1XPV8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crotonyl-CoA carboxylase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccrA</name>
        <name evidence="3" type="ORF">BLA24_02590</name>
        <name evidence="4" type="ORF">CYQ11_04885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53221">
        <property type="protein sequence ID" value="PHQ53221"/>
        <property type="gene ID" value="BLA24_02590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12313">
        <property type="protein sequence ID" value="PPT12313"/>
        <property type="gene ID" value="CYQ11_04885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043880">
        <property type="term" value="F:crotonyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010085">
        <property type="entry name" value="Crot_CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01751">
        <property type="entry name" value="crot-CoA-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="49"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="447" mass="48591" checksum="0AED7D9208CD8587" modified="2018-01-31" version="1">MDQILSAILSDDAVSEDFAALPLPESYRGVVVLAEETAMFDGMASSDKDPEKSLHVQDVPTPEPGPGEVLVASMASAINYNTVWSAIFEPLPTFGFLKRYAQSSALHARHFQPYHVVGSDMAGVVLRTGPGVERWKPGDRVVATAHQAAMDTPDGYDDSMLDPSGRAWGFETNYGGLAELALVNGTQLMPMPEHLTWEEAACSTLCNATAYRQLASPNAAGMKQGDVVLIWGATGGLGSYATQLVLNGGGIPVCVVSSESKAELVRGMGAELVINRAAEGYRFWADENTPDPREWKRFRARIRELTGGDDPDIVFEHPGRETFGASVFAARQGGTVVTCAATSGYQHVYDNRYLWMSLKRIIGTHFANYREAAESNRLIAKGMVHPTLSKVFPLEETGMAARDVHRNRHSGKVGVLCLAPEEGLGVRDARLRERHIDAITRFRRAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPV9</accession>
    <name>A0A2G1XPV9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ruvB</name>
        <name evidence="9" type="ORF">BLA24_02885</name>
        <name evidence="10" type="ORF">CYQ11_05180</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53274">
        <property type="protein sequence ID" value="PHQ53274"/>
        <property type="gene ID" value="BLA24_02885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12369">
        <property type="protein sequence ID" value="PPT12369"/>
        <property type="gene ID" value="CYQ11_05180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="364" mass="38719" checksum="B37B91ED6B58E75D" modified="2018-01-31" version="1">MNWDDESAYATPPAGDRLVGTTADGEDQAVEAALRPKDLGEFIGQERVREQLDLVLKAARARGATADHVLLSGAPGLGKTTLSMIIAAEMGAPIRITSGPAIQHAGDLAAILSSLTEGEVLFLDEIHRMSRPAEEMLYMAMEDFRVDVIVGKGPGATAIPLELPPFTLVGATTRAGLLPPPLRDRFGFTGHMEFYAPAELQRVVHRSARLLDVEIDEKGAAEIAGRSRGTPRIANRLLRRVRDYAQVKADGVITQEIAAQALQVYEVDGRGLDRLDRAVLTALLKLFGGGPVGLSTLAVAVGEERETVEEVAEPFLVREGLLARTPRGRVATPAAWSHLGLVPPQQGGGRAGAGGSDQHGLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ62</accession>
    <name>A0A2G1XQ62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaL</name>
        <name evidence="2" type="ORF">BLA24_02195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53331">
        <property type="protein sequence ID" value="PHQ53331"/>
        <property type="gene ID" value="BLA24_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="306" mass="30961" checksum="940EFF1563C7CEE7" modified="2018-01-31" version="1">MLDLDFFRRFLDRATRVIVAAAPRLTDLDAAIGDADHGANLKRGFTSAAATVADEPPATPGALLTAVGVHLTNTVGGASGPLYGTVLRRMGKVLGEDEVVEPETLGRALAAAVASVRRLGDSAPGDKTMVDALQPAADAYAAALAEGDVTAALDAAARAAREGAEATVPLLARRGRASYLGERSIGHQDPGAASSALLVTALYEATDPRLCAVEPEPAEPAVSAEVAEEPPALVGLVLVSHSRDVAESTAALARALVGGGEPAPVAAAGGVPGGGSVRARSWSARPCATWTGGRAWSCCATWAARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ83</accession>
    <name>A0A2G1XQ83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01705</name>
        <name evidence="2" type="ORF">BLA24_25715</name>
        <name evidence="4" type="ORF">CYQ11_20355</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000029">
        <property type="protein sequence ID" value="PHQ53370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49441">
        <property type="protein sequence ID" value="PHQ49441"/>
        <property type="gene ID" value="BLA24_25715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53370">
        <property type="protein sequence ID" value="PHQ53370"/>
        <property type="gene ID" value="BLA24_01705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14909">
        <property type="protein sequence ID" value="PPT14909"/>
        <property type="gene ID" value="CYQ11_20355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="60" mass="6985" checksum="AE78995F17467E53" modified="2018-01-31" version="1">MSLGGSNRLLTPEEVADWLKVSEITVKNKYRTWGIKAQKVGRLLRFRERDIVAYLEDNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQE1</accession>
    <name>A0A2G1XQE1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_00560</name>
        <name evidence="7" type="ORF">CYQ11_07570</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53458">
        <property type="protein sequence ID" value="PHQ53458"/>
        <property type="gene ID" value="BLA24_00560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12763">
        <property type="protein sequence ID" value="PPT12763"/>
        <property type="gene ID" value="CYQ11_07570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="182" mass="18768" checksum="438A08A282B24879" modified="2018-01-31" version="1">MAFRSRNDVLAGRGGVAYRTLPAGCSLGLLLLRMMLGVIMMAHGTQKLFGWWDGPGLDGTAKFFQLYGYPAPRAMAVVAGLSETLGGAGLFLGFLTPLAAAAVLGTMINALGVTWEGGFLLPKGVEFTLLVAVGAAALALTGPGEFAVDRFVPGLRGHRLAYGVAAIALACVVGAVFLLVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ9</accession>
    <name>A0A2G1XQJ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsZ</name>
        <name evidence="11" type="ORF">BLA24_00730</name>
        <name evidence="12" type="ORF">CYQ11_07740</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53490">
        <property type="protein sequence ID" value="PHQ53490"/>
        <property type="gene ID" value="BLA24_00730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12795">
        <property type="protein sequence ID" value="PPT12795"/>
        <property type="gene ID" value="CYQ11_07740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="417" mass="42528" checksum="D0EBA6F1C748AEE4" modified="2018-01-31" version="1">MAAPQNYLAVIKVVGIGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPDVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAGLRDEVDTLIVIPNDRLLSISDRQVSVLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPAKGSRDKVLGGSSSYGSAREESSAATTPASRQAAPSAEPARPSFGGLGSVTPRTEEPVPADPSPVAEVPPPPVASPQVPPARPYQDSTAEELDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQZ0</accession>
    <name>A0A2G1XQZ0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000009">
        <property type="protein sequence ID" value="PHQ53579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53579">
        <property type="protein sequence ID" value="PHQ53579"/>
        <property type="gene ID" value="BLA24_00235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="224" mass="24014" checksum="04EA951C0E637F3A" modified="2018-01-31" version="1">MDVWNSEAHGSVAVLGDSITDGVSATVDADHRWTDYLAARLNSEPGAPRYGVLNEGISGNRVLLSGQGASPTANPSALERFDRDVLSRAGVRVVVVELGINDILRQPQQADPGRITAGLRQLVDRAHLRGLRVIGSTLTPFGGRTGAGPQHEAVRQGVNEEIRAGRVFDDVVDFDQALRDPEQPQRLLPAYDCGDHLHPSDAGYRAMADTLDVEKLKAQPAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9F5</accession>
    <name>A0A2G1X9F5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30600</name>
        <name evidence="3" type="ORF">CYQ11_23695</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47860">
        <property type="protein sequence ID" value="PHQ47860"/>
        <property type="gene ID" value="BLA24_30600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15485">
        <property type="protein sequence ID" value="PPT15485"/>
        <property type="gene ID" value="CYQ11_23695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="406" mass="42977" checksum="C29238800F18F857" modified="2018-01-31" version="1">MSGSSAGPTAAGAAWHDPVPLDPRSAPLPRYGTGSLADLLPTVAAGLGVPGLSAGMELAPADRVCVFLIDGLGWELLRAHPAEAPFLHSLLSTSMNGTGTPMTAGFPSTTATSLASVGTGLPPGAHGLPGYTVADPATGALMNQLRWRPWTDPHAWQPYPTVFQLADAAGIATCQVSAPDFQHTPLTKIALSGGTFHGRLSGEERMDLAADRLGAADRSLVYTYYSEVDGKGHRFGVDSEEWRGQLMYVDLLAQRLAEQLPPRSALYVTADHGMIDIPFDPESRIDFDEDWELRAGVALLGGEARARHVYAVPGAASDVLAVWREVLGEQMWVAGRDEAIEAGWFGPPGEGVDDRVYARIGDVVAAARDDVAIVATETEPNESTMVGLHGSMTPVEQLVPLLEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9M4</accession>
    <name>A0A2G1X9M4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1998 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30975</name>
        <name evidence="5" type="ORF">CYQ11_24075</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47925">
        <property type="protein sequence ID" value="PHQ47925"/>
        <property type="gene ID" value="BLA24_30975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15550">
        <property type="protein sequence ID" value="PPT15550"/>
        <property type="gene ID" value="CYQ11_24075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="91"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2109"/>
            <end position="2138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="2262" mass="247412" checksum="6D816AEF650374D6" modified="2018-01-31" version="1">MRPTLAADQVRGSLSQYLSTTYALADESTRSALEQFLGDAEDGIFRGPYLRIRTPFRVAEGDDWQRHLTWWPRVKDFTPYRHQERAWERLSTLHGPARPTLVTTGTGSGKTESFLVPLLDHCRREREAGREGVKAVLLYPMNALATDQAHRINDYLGNPRDARLRDAGVRAALYIGDKASKEFKQANPRVAVDRDEIRRTRPDILITNYKMLDLLLQRPEDQRLWREADGSALAFVVLDEFHTYDGAQGTDVAMLLRRLGAVAGLDEPGRPLGPVCPVATSATLGESGSGAAGGSMLDVAEQVFGVPFPPEAVVGEDRHSAQEFAGDSDFTLPFPSPHEVADLGDPTRDPEALDRLAAAFTGKSGLSPQQLGRQLRRHRLTAAVLEILDGRPRTMAEVMDVLPRYAYHWGMAVQQNPAMAAQALARYIALLSTARDPDHPARPLLSIEVHHWVRSVSRLLRGVSAARAEFRWDDERVAAGGRLAARTGGGAAAGGSGTVPTDDAAQAVPAGDSAPPPAQVFLPAVFCRECGRSGWAALSPEADPAELDMKATKIRRASVGRDKSRVRNMISATPQQAYDAAFVTEKARGGPTVMVLDGLTGRLRPLSPEADFQALRDGAGPRVAKPLHDAAFVWVDLADDRAAQGDQCPACRTFNAIRYLGTGLAALAAASITQLFTGGELDKNLKEDKTLLFNDSVQDAAHRAGYVASRSYTFSFRSLLTSRIDEDEPIALSDLAADLIADVVDSKAVQAAVIPPDLHVVRGVDTLLSGRSRGSRATWELIAQRLAFAAVLEFGLRSRQGRTLELTRTVAAEVPLEDPDAIAEIVRELLHTTPGDISLPDGSLPGPDRWIGHVRGLLERLRTRGAIRHAWLDGWLDQAGVRRWLIWGGRKTGMPAFPPGVSAPAFLLGSPKQGSDDFDVVTGRLGWYQDWTRRSLGLRPDAANAFLGRLLPALVDAGVLSARTAKDGATRVYGLQPGHVQVRKLADDCVADASAHCPVCSWEQTVHPDLADQWHGQPCPRYRCGGLLRTGQDLESGVRRRDFTQDFYRRMYREAGVFTINTAEHTGTLSRPKREAVEKAFRAGTGAHYANPQVLSCTPTLELGIDIGDLSAVVLASLPKGPANYVQRVGRAGRATGNAYLLTMVDRGPRDRYYLEDPRQMIAGDIQPPGCFLSAIEILRRQYLAHLLDLAGAGRLPAPDGDGAAIHPLPRLATELFGPSGWLSEFQKAALAQGPLLAEKFLALFPPYVEAKGIGVSPQAADELRAYATGGLAGALDKARTQWEDHRDEMQRRIKTIDEAYQALVAGDPEHERQGRELRAERRAVARRAGEISRATAHGTLVDLGLLPNYSLVDSVTELEATLTWREEGKDGQPEHHSKVLKYDRPARLALSDFAPGNHYYIQGYKHRITGLDVGSPGRPAWLWWRVCPDCGHVRTHQARQDSSACPRCHSAAIGDVGCLHKVLVPHRVLARDQRDDVRVRDDTDERERRHYTVVPAVDIPQEHVETAWRHKKATFGWEFTRQAVIRHINVGASRVDTGADEAFAGRRVRLNPFWVCDSCGYADADGGPAAAHAGQQDALVAHRVTKYHRPWCPRLRDGLGETRAAQQGVRLLLAHELRSEALRILIPAVTAHTQERLVSFKALLLAGIAQSYGGDPDHLAVVTDSMPEPGSDVRRHFLVLYDALPGGTGYLHRLAGPDGLHDVLTRARQVIERCPCVGENRPACHRCLLRYVSDSEYELVSREHALDMLGELLGRAGDGWDIEEAATTRDITLVQQVESELEALFRRGLLAWAERVDEVSVRTALTPDGERDTTLRFTAPDGTVSGWRMETQTDLGFTVPDVVFRSLDDDRRRVAVYLDGYRYHASPDHNRIAGDAAKRTRLRAGHGWQVFQLTWDDVRAWTGETKPPAAPVWVPYQNTAQKTASDIHRRVHGGDPRDLPRFVWANPVETLIGYLTTPDHEVWRRRAQSVLAGFAAVSATSRALADGPEIGHRIADALTGKRLSGGQGAVQVMATQDGSGCPLTIALDLRKGQAGASWTALTVLDDSPDAVAGDENAHRRRWQAWLYWTNLLQFLNEGEGDGVQLASSQLPGFDPVELAVTGGAGWLESRRQSPEPDAEGEAASGPHTVPAAEPAGEVLRDPAWDEVIEYLVEEPGLAELADALAASGAPAPDAGYELGEAAWPAELAWPTHRIGVVLAHRRGADGAEDRDAEDRDQAYAAAGWTVRTAAEWDARELADALLRPAGADHRPAMNDDEEHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9R8</accession>
    <name>A0A2G1X9R8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31500</name>
        <name evidence="3" type="ORF">CYQ11_24545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47984">
        <property type="protein sequence ID" value="PHQ47984"/>
        <property type="gene ID" value="BLA24_31500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15609">
        <property type="protein sequence ID" value="PPT15609"/>
        <property type="gene ID" value="CYQ11_24545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="38433" checksum="21FEEB15864ED9FC" modified="2018-01-31" version="1">MAVRTSTPTTGWLLRGKDGRLTAYAPVSGGVVRWTETRPGGPEWTGPERVEVPGLEPYLSIAQSPEGYVSLAGLRRRAHDDGRAETDVVYSTQFQSGRAMTTWRSVGTPYGQDWQRADQIGVPTAVRDSVGLHLLVRNAGGGVCGRRQDARGIWGPWTDMKGSHLLDTVSGATTADGRIELFGPASEFVLRWRQEEPGGPLRRVLNTPAKPLTGTATSFPTGDGRVAHVWRDATDSVLQHLSPAAPTGPGSEEGAEAAAPTALVSLGGDGTGPVAALRTTLDGHPSTVLAQRSGSGLPAVTAYPDGEDVPTDAAWSQTGEECAGAPALALDAQGRVVLAVIATDGTLRVARQRTAEAGLALGPWERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9W4</accession>
    <name>A0A2G1X9W4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NERD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31595</name>
        <name evidence="4" type="ORF">CYQ11_24645</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48001">
        <property type="protein sequence ID" value="PHQ48001"/>
        <property type="gene ID" value="BLA24_31595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15627">
        <property type="protein sequence ID" value="PPT15627"/>
        <property type="gene ID" value="CYQ11_24645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="2">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="270" mass="28831" checksum="9C7C8D167873D4AC" modified="2018-01-31" version="1">MGSTRRPRPPFAPALPPNRADTVGSPASAAGWRVGVMGVCERPEAKRSAIGRPYDPERLFLPPDDDLAPNRPGETLRARLDASRTGRAGLVLARLLGRRPVEDSWRRRLAAEQVVGAELEELTAGGWEVVHSIVLPGGPASAVISHLLIGPGGVFCVASEPTRRAHAEVGDSAVRVVGERHPRPCVRRARHSAARASLALSRGCGFLVRVLPVLVLVGPPSWEVAASLEDVRVLGEREVAGLGALGGALHPHRVDRIHTVARNRRVWLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA95</accession>
    <name>A0A2G1XA95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32385</name>
        <name evidence="2" type="ORF">CYQ11_25435</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48131">
        <property type="protein sequence ID" value="PHQ48131"/>
        <property type="gene ID" value="BLA24_32385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15757">
        <property type="protein sequence ID" value="PPT15757"/>
        <property type="gene ID" value="CYQ11_25435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046245">
        <property type="entry name" value="DUF6278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19794">
        <property type="entry name" value="DUF6278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="15876" checksum="9BBC8C5F3E6EC634" modified="2018-01-31" version="1">MNIPFLDSWRKRHEAARGLASPRGAERDPEGLAELLSECELLRAHAQSAGVALDDSPSSLEALDQLQPRWREDPELVPWLGNDAGLYLGTAVVRTVPGAGWWVRAADGQPVVRLASGREIDVVEAGQAWAADGAPQLSQLYAEVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAA7</accession>
    <name>A0A2G1XAA7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32530</name>
        <name evidence="7" type="ORF">CYQ11_25580</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48153">
        <property type="protein sequence ID" value="PHQ48153"/>
        <property type="gene ID" value="BLA24_32530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15779">
        <property type="protein sequence ID" value="PPT15779"/>
        <property type="gene ID" value="CYQ11_25580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="170" mass="19084" checksum="DCC957D7418EC956" modified="2018-01-31" version="1">MQFGRTYEEFTVGDVYKHWPGKTVTEYDDHLFCLLTMNHHPLHMDSNYAEETTDFGKNVVVGNYVYSLLLGMSVPDVSGKAIANLEVESLKHIAPTFHGDTIYGETTVLDKTPSKSKSDRGIVHVETRGYKQDGTVVCVFRRKVMVPTATYIKERGGEQPGRPEPITGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAI1</accession>
    <name>A0A2G1XAI1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32675</name>
        <name evidence="3" type="ORF">CYQ11_25725</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48179">
        <property type="protein sequence ID" value="PHQ48179"/>
        <property type="gene ID" value="BLA24_32675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15805">
        <property type="protein sequence ID" value="PPT15805"/>
        <property type="gene ID" value="CYQ11_25725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="398" mass="40773" checksum="825399CFCB5AD821" modified="2018-01-31" version="1">MQQGSAALPGPGLPVLPELAARLAEAAGRTGPEPLGGGTALRSAAAGYWARRGLPTEPGRVVAAPGAQPLLLALFASAGGEVLLTRPCAPWYGPLARLAGRLAYHVPVPAECGGVPDPFALLETVRRIRAEGGRPRFLVLSVADDTTGTVAPPEILHEVCEAAAAEELTVVSDETWRDTVHDPPPATVFVSPAEMYPDRVVVLTDLAGALTPTAWPAAVARFPAAGTGPALHARAASVLAALRAELPPPIAAAASLALSEPAPVRARTAAAARLYGVLGEALRQRLDAAGALCRPSQTGPHLYADLGELRDALAARGITDSVELEAHLGAVLGHPAPGGHRFGDVPDSLRVRLSTLALLGPADDQRQRALDAPDPLRSPGVAEALSTFGSAFSELAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAJ8</accession>
    <name>A0A2G1XAJ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33095</name>
        <name evidence="3" type="ORF">CYQ11_26145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48250">
        <property type="protein sequence ID" value="PHQ48250"/>
        <property type="gene ID" value="BLA24_33095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15880">
        <property type="protein sequence ID" value="PPT15880"/>
        <property type="gene ID" value="CYQ11_26145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="132"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="29378" checksum="A18E683F301A5C86" modified="2018-01-31" version="1">MTQTPHVPSHRPQAETLLAGVRNFRDLGGLPAADGRRVRPGVLFRSGHLAHATAEDVVFLKSLGLHTVFDFRNAADIELEGPDVALTGVRNVNIPLSDPADGSAFWRMVRDGDLDVLRSVLGDGRAAGRMSRSYRTIITTRTAEHSRVLHTLADGGVPALMHCAAGKDRAGLSIAVTLLALGVTPEAVEADYLESNAPHRRYRVRRGDAMDGQATPEVMELLSPLFEARAEYLAAAFAAVAETWGTTDRYLAEGLGLAPATRERLRDLLLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAK1</accession>
    <name>A0A2G1XAK1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_33205</name>
        <name evidence="2" type="ORF">CYQ11_26255</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48267">
        <property type="protein sequence ID" value="PHQ48267"/>
        <property type="gene ID" value="BLA24_33205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15897">
        <property type="protein sequence ID" value="PPT15897"/>
        <property type="gene ID" value="CYQ11_26255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="146" mass="15957" checksum="C553FBDF6ADC1BED" modified="2018-01-31" version="1">MLTGDTFSSSTFAIELGKFQVETVQDVSGLTLEQDVVEVRQVSATGELIVRKQPGARKTGEITITRGMDKSTAFTDWIKATLVNADLDSARQNITIALKDAQKQTVRRIHLSNAWASRWEGPQLGAANSGNATEQVTITYEDITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP3</accession>
    <name>A0A2G1XAP3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl carrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Curamycin polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_33355</name>
        <name evidence="7" type="ORF">CYQ11_26405</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48290">
        <property type="protein sequence ID" value="PHQ48290"/>
        <property type="gene ID" value="BLA24_33355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15921">
        <property type="protein sequence ID" value="PPT15921"/>
        <property type="gene ID" value="CYQ11_26405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="86" mass="8977" checksum="869F3BFE7D092DA1" modified="2018-01-31" version="1">MTIKELTFGELAALMKQSAGVTGDPARLEQAPDTPFASLGVDSLGLLGIVGELENRYAVSLPTDAERCKTPAEFIGVVNDALKTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAY0</accession>
    <name>A0A2G1XAY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_13075</name>
        <name evidence="2" type="ORF">BLA24_30125</name>
        <name evidence="3" type="ORF">BLA24_30150</name>
        <name evidence="5" type="ORF">CYQ11_17435</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000167">
        <property type="protein sequence ID" value="PHQ48397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000167">
        <property type="protein sequence ID" value="PHQ48398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003953493.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48397">
        <property type="protein sequence ID" value="PHQ48397"/>
        <property type="gene ID" value="BLA24_30125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48398">
        <property type="protein sequence ID" value="PHQ48398"/>
        <property type="gene ID" value="BLA24_30150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51620">
        <property type="protein sequence ID" value="PHQ51620"/>
        <property type="gene ID" value="BLA24_13075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14413">
        <property type="protein sequence ID" value="PPT14413"/>
        <property type="gene ID" value="CYQ11_17435"/>
    </dbReference>
    <dbReference type="GeneID" id="63981650"/>
    <dbReference type="GeneID" id="67401070"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17829" checksum="0D8F10F093DB8DAB" modified="2018-01-31" version="1">MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLTVRVPADNAEFVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKVAEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAY3</accession>
    <name>A0A2G1XAY3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32955</name>
        <name evidence="3" type="ORF">CYQ11_26005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48383">
        <property type="protein sequence ID" value="PHQ48383"/>
        <property type="gene ID" value="BLA24_32955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16808">
        <property type="protein sequence ID" value="PPT16808"/>
        <property type="gene ID" value="CYQ11_26005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="180" mass="19503" checksum="5151570E121FFD2D" modified="2018-01-31" version="1">MRKVIASVYVTLDGVMENPAWSAPYFNDEAGAFARAQLFAAEALLLGRVTYQGFAQAWPSMTDGDGFADRMNAMPKYVATTTLDTPEWNATFLTGDVPAAVADLKRQDGGDLLVYGSGDLVNTLLEHDLLDELRLWTHPVVEGTGKRLFTEVSPKKTLRLVGTTTFATGAQVLAYAPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB59</accession>
    <name>A0A2G1XB59_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29285</name>
        <name evidence="4" type="ORF">CYQ11_06190</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48463">
        <property type="protein sequence ID" value="PHQ48463"/>
        <property type="gene ID" value="BLA24_29285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12542">
        <property type="protein sequence ID" value="PPT12542"/>
        <property type="gene ID" value="CYQ11_06190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="275" mass="29717" checksum="8F6C5472C7C18361" modified="2018-01-31" version="1">MSAFLRPAASEEDPETSGGRYRPVTSQFAIAPPVSVVIPAMNEAENLPYVFKTLPDWIHEVVLVDGNSTDDTVGVARGLRPDVKVVEQLGKGKGDALITGFAACTGEIIVMVDADGSADGGEIVSYVSALVGGADFAKGSRFANGGGTDDMTFVRKLGNRVLTSMVNHKFGARYTDLCYGYNAFWKHCLDEIALDCAGFEVETLMNIRVVKAGLRVQEIPSHEFVRIHGASNLRAVRDGIRVLKVILRERGVRRGSRRRQRPLAIAPAANRGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB94</accession>
    <name>A0A2G1XB94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29350</name>
        <name evidence="7" type="ORF">CYQ11_06125</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48471">
        <property type="protein sequence ID" value="PHQ48471"/>
        <property type="gene ID" value="BLA24_29350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12531">
        <property type="protein sequence ID" value="PPT12531"/>
        <property type="gene ID" value="CYQ11_06125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="22965" checksum="9C92E20A846A9ACC" modified="2018-01-31" version="1">MGTQAQRTEQWADVTPDAARRLLTAAVEAFAERGYHATTTRDIAGRAGMSPAALYIHYRTKEELLYRISGVGHRLALGILRRAHDGPGSPAERLADAVRRFVRWHAEHHTTARVVQYELGALGEEHHAEIVALRRETDAAVRAIIEEGVAAGDFDVPDVRGTSLAVLSLCVDVARWFSVDGRRTPEEVGDLYAGLVLRMVGHGNGVRAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBA7</accession>
    <name>A0A2G1XBA7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">prcB</name>
        <name evidence="4" type="ORF">BLA24_29680</name>
        <name evidence="5" type="ORF">CYQ11_05795</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48527">
        <property type="protein sequence ID" value="PHQ48527"/>
        <property type="gene ID" value="BLA24_29680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12474">
        <property type="protein sequence ID" value="PPT12474"/>
        <property type="gene ID" value="CYQ11_05795"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5034593653" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034593652" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="53"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="30078" checksum="E1DBD6F98971AAC7" modified="2018-01-31" version="1">MEANPRSIGRLPAAFLTPGSSSFMDFLAQHQPDLLPRNRQLPAQGVLEAPHGTTIVAASFPGGVVLAGDRRATMGNVIAQRDIEKVFPADEYSAVGIAGTAGLAVEMVKLFQLELEHFEKVEGVSLSLEGKANRLSTMIRSNLGMAMQGLAVVPLFAGWDVDRQKGRIFSYDVTGGRSEEHGFAATGSGSLFARGALKKLFREDLTEGQATTLVVQALYDAADDDSATGGPDLARRIYPIVTVITDEGFRKLTEAQCSEIVRAVHERRLEEPDGPRAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBC0</accession>
    <name>A0A2G1XBC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29395</name>
        <name evidence="3" type="ORF">CYQ11_06080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48479">
        <property type="protein sequence ID" value="PHQ48479"/>
        <property type="gene ID" value="BLA24_29395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12523">
        <property type="protein sequence ID" value="PPT12523"/>
        <property type="gene ID" value="CYQ11_06080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="15811" checksum="D0006B0E4F027A40" modified="2018-01-31" version="1">MTGSTTPPPTKAQLLELVAALGTAQWQDFAAAAGRHGLTSVQAKLLSQLKGPVPMRGLATLLVCDASNVTGIVDRLEARGLVRREPDPADRRVKNVVATDEGREIIQRVRGEMQATHSALDALDEEERATLYRLLEALRPGLEHGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBF0</accession>
    <name>A0A2G1XBF0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29785</name>
        <name evidence="7" type="ORF">CYQ11_05690</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48542">
        <property type="protein sequence ID" value="PHQ48542"/>
        <property type="gene ID" value="BLA24_29785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12457">
        <property type="protein sequence ID" value="PPT12457"/>
        <property type="gene ID" value="CYQ11_05690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="374" mass="37963" checksum="B76DFB3729119C6D" modified="2018-01-31" version="1">MTTTRSHTPLRHLGPNWYATVMGTAIVASAGAALPGDTGGLRGAFEAVWAVAALALLVLLAARAVHWARHPDQARRHLADPAVAPFYGCLAMALLAVGGATLSVGSGVIGADAAVRADAVLWVTGTVVGLGAACAVPYLMVTRHRVAPGDASPVWLLPVVAPMVSAALGPALVPHLPAGQWREAMLLGCYALFGASLLATLVILPVVFSRLVHHGPLPLALTPTLFLVLGPLGQSTTAVGNLADVAPGAVGQPYARAMAGFAVLYGAPVIGFALLWLALATALVVRAFRGGMGFAMTWWAFTFPLGTCVTGAAGLARHTGLEAFTWLAVGLYAVLVAAWAVAGARTLAGLLSGGLLAAPRPAPVALGSTTVRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBK5</accession>
    <name>A0A2G1XBK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29295</name>
        <name evidence="4" type="ORF">CYQ11_06180</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48590">
        <property type="protein sequence ID" value="PHQ48590"/>
        <property type="gene ID" value="BLA24_29295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12540">
        <property type="protein sequence ID" value="PPT12540"/>
        <property type="gene ID" value="CYQ11_06180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="15130" checksum="798C6AE1E0AA3B01" modified="2018-01-31" version="1">MQSFTDLTGLDEPTEPDGAGGEEGPIGGRRPAGDSLPVIAGAATAIAGVGGALALADIGSPLRAPFTLFFLLVAPACALSAVLRGLDPLSRSVVATGGAVAVDLLIAETMLALHTWSVRGGVAAVAAVSLLLYLLAHARRHRGRAARSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBU9</accession>
    <name>A0A2G1XBU9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_28695</name>
        <name evidence="7" type="ORF">CYQ11_06770</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48688">
        <property type="protein sequence ID" value="PHQ48688"/>
        <property type="gene ID" value="BLA24_28695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12631">
        <property type="protein sequence ID" value="PPT12631"/>
        <property type="gene ID" value="CYQ11_06770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="29609" checksum="A3CAD0E6A834C963" modified="2018-01-31" version="1">MYRFLLTRQWVILTLVGLALIPVMIKLGFWQLHRHEQRVARNNQIGESLAHAPVPITGLTGPGREVAHESVWRRVTATGTYDTKGEVVARYRTDESGKSGYMVITPLVLDDGTAVLVNRGWIPADAGQREFPSVPAPPGGKVTVTGRLRADETAGSGIRDTKGLPARMIMIINSERQAEVLHRPVLGGYVELVSPTGDGQPQPVPSPDHSSIGNHMAYAVQWWLFSAFVPVGWVILVRRERRDRAAEAAAATAGTTTEPAEPAAGVAASSTSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBX2</accession>
    <name>A0A2G1XBX2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000157">
        <property type="protein sequence ID" value="PHQ48754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48754">
        <property type="protein sequence ID" value="PHQ48754"/>
        <property type="gene ID" value="BLA24_28125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase_6" evidence="1">
        <location>
            <begin position="104"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="281" mass="31583" checksum="3AE761B10C54C4FF" modified="2018-01-31" version="1">MRQASQADKKASAELDKLATKINVSDTNVAHNYIETETAHLEIDMIRGSIPVGKDPHLVRAWWDGLTPEQHKALMLADPVTIADLTGLPDDVGKEIRGRDGKIDRVEMVRYALDHWNKPDDLKFENNCANFASSALEAGGMQKKFDTWLGPRGDNTWGRESGIGIDWWDQRAYHSRSWASAKYLRNFLTDNGGEEVPRSQARPGDLIFYEQVAEDPGKGGEPQGETYHAAVVTSVTPDGDIKLSQHTGEWQNVSLEAREHVATRNHGEQRIHIVRPHPNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC56</accession>
    <name>A0A2G1XC56_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27475</name>
        <name evidence="3" type="ORF">CYQ11_18170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48812">
        <property type="protein sequence ID" value="PHQ48812"/>
        <property type="gene ID" value="BLA24_27475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14541">
        <property type="protein sequence ID" value="PPT14541"/>
        <property type="gene ID" value="CYQ11_18170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="11"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="480" mass="50605" checksum="578F7ECE32B18A23" modified="2018-01-31" version="1">MSPPTGPEADADVLVVGAGPTGLLLAGDLAAAGVRVVLLERRDQESNLTRAFAVHARTLEVLDIRSVAEKLMETGTFLPGLRLFGPARIDLTGLPTRFAGVLMTPQYETERVLQDRAVRHGVEIRRGARVTGLRQDAHGVSVDVGPGPGTDGASYTLRARYAVGADGVHSAVREALGMPFPGHSVVRSVMLADVRLDSAPAQTPTVRTGDEGFVFLASFGDGWYRVIAWERGCDLPSDAPVDMEGLRALVRACYGTDFGMRDARWTSRFHSDERQVPRYRDGRVFLAGDAAHVHSPAGGMGMNTGLQDAANLGWKLAAVVHGQASDDLLDSYDAERHPVGRGVLRLSGGLVRAALAGSRVKRGLRNAAIAGAFAAPGVVRRGALFVSGIGISYPAPRGSHPLTGHRAPDLPLAETGDGKGPTRLYEALRGGTYVRVLPRGAKAPADGGGMPVTTVTRADASGTSLLVRPDAYVERAAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB3</accession>
    <name>A0A2G1XCB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27790</name>
        <name evidence="2" type="ORF">CYQ11_17850</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48866">
        <property type="protein sequence ID" value="PHQ48866"/>
        <property type="gene ID" value="BLA24_27790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14487">
        <property type="protein sequence ID" value="PPT14487"/>
        <property type="gene ID" value="CYQ11_17850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="9663" checksum="47835A3FE8B9A412" modified="2018-01-31" version="1">MKLRFLGIIPNTGKDDSPTIWLDQDSGDLLIQSYRATEEELKACKEIGSIPGHSTDVPDHETVIRLPKVMLQYIPRPDGDAADEAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCD2</accession>
    <name>A0A2G1XCD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27765</name>
        <name evidence="6" type="ORF">CYQ11_17875</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48861">
        <property type="protein sequence ID" value="PHQ48861"/>
        <property type="gene ID" value="BLA24_27765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14492">
        <property type="protein sequence ID" value="PPT14492"/>
        <property type="gene ID" value="CYQ11_17875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="4">
        <location>
            <begin position="525"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="819" mass="85153" checksum="BB035F7E8F9CAB0F" modified="2018-01-31" version="1">MTTSRETGSTGGSTGGAPRTLAEELRTRPDEALAALLRARPDLLNPVPGDLTQLATRASTRASVVRALDRLDRFALQVAEALAVAPDPCPYTTLSGLMTGDEASDPRVAAELPRAVATLRDQALVWGGEDRLRLVRTARELLAPSAAHLSPTGLGPTVTEATAGMSPGRLQRIIEAAGLPATHDPVSAVAALTALFEDRSRMAALLAGAPAEAQAVLGKLLWGPPHGTVTAEPASHLRWLLDRGLLLPTGPGSVVLPREAALHLRAGRAHRCPEPLAPDLAPVTEHPSATVDAGAAGQAFTALSVVEDLLTDWETAGPLVLRAGGLSVRDLKRTAAVLDTTEGDAAFWAELAYAAGLLASDGDVDERYAPTPEYDDWLALPAERRWTRLATAWLATTRTPALAGEKDAKGRALAVLGPDLDRGPAPEVRRRVLDLLASLPPGASVSADTLLARLAWERPPRSATDDLRSRLALSALAEAETLGLTSRGALAAHARTLLAGPDPDTAAARAGAELAPLLPRPVDHVLLQADLTAVAPGPLLRPLAQTLAVLADVESKGGATVYRFTPGSVRRALDAGRTAADLHAFLAGHSLTPVPQPLAYLIDDVARRHGRLRVGAASSYLRCDDEAVLAEILADRRSAPLRLRRLASTVLAAQAAPDTLLETLRAMGYAPAAESAEGDVVITRADAHRTPPRTAPAPVPEGPPVPGDTLLGAAVRAVRAGDLAATAHRKPSGAPAPADGGLPRTTSADTLATVQAAVLTGAAVWIGYVNAEGGASQRVIAPIRVEGGFVTAYDHTADEVRTYPLHRITGVAELADDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCF0</accession>
    <name>A0A2G1XCF0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27635</name>
        <name evidence="3" type="ORF">CYQ11_18005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48839">
        <property type="protein sequence ID" value="PHQ48839"/>
        <property type="gene ID" value="BLA24_27635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14515">
        <property type="protein sequence ID" value="PPT14515"/>
        <property type="gene ID" value="CYQ11_18005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="9"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="309" mass="31835" checksum="E6F5A6FEE74A37E4" modified="2018-01-31" version="1">MRALLVDRSARAGLRLAQVPDPDPAPHQALVRVEATSLNYGEVRFGLQEAADGTVLGWDAAGVVERAAADGSGPAAGTRVVTLGPAGGWAELRAVDTDMMGVVPAGADLGAVSTIPVAGATALRALHRLGPLLGRRVLITGATGGTGRYAVQLARRGGAHVIASTGAPERHGDGLRDLGAHDVVAEPLRVAEPVDGVVDLVGGRQLVDAYGRLAEGGNLVAVGHSAHEGETFPYGALYGDQGRHDRSLTTFFLLACTGLARDLTWLAHQVATGGLTPHISWRGTWGEAADAIAALLDRRLHGKAVLDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCV2</accession>
    <name>A0A2G1XCV2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23540</name>
        <name evidence="3" type="ORF">CYQ11_22530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49066">
        <property type="protein sequence ID" value="PHQ49066"/>
        <property type="gene ID" value="BLA24_23540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15288">
        <property type="protein sequence ID" value="PPT15288"/>
        <property type="gene ID" value="CYQ11_22530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="236"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="329" mass="35405" checksum="CBD53A40C42FCF92" modified="2018-01-31" version="1">MPFASARGIFSCVLPPPVGQRHNPGMVHPNGLRGRVHVGDLRPGDHACLLFESDEERASILRDFVLGGLEAEDKILYLSGAEDPPGPGALLDECRLPEPPGGLADRVEVVRLAEFLSGRGQFEPAALLRRLRSAAERSRQQGYRTLRVAGDLCAALHDGGGAFSALDVARLLRYEALLAEEFSSGGALAVCQYDIRRCGPAALDAFASAHVSSVEADPLVRTAELVVVRTYRPQGLRVEGVVDAEAHPCLRDALRSVAGVRGDVRLEMSRVEFLDLAGLRLLMTFARARAARHCTVELAGLPPHLLQVITVVGWDRTPGLRLGAAHACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCV7</accession>
    <name>A0A2G1XCV7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAK2 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23455</name>
        <name evidence="3" type="ORF">CYQ11_22615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49050">
        <property type="protein sequence ID" value="PHQ49050"/>
        <property type="gene ID" value="BLA24_23455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15304">
        <property type="protein sequence ID" value="PPT15304"/>
        <property type="gene ID" value="CYQ11_22615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="566" mass="57352" checksum="9C44F74E87B8BAAF" modified="2018-01-31" version="1">MPHTPPDSVRGRPLDADAVRTWCALALEGLGRAREEIDAINVYPVADGDTGTNLYLTVESATRAVDAVFEGHATTGPGSRPGLAEAVRAMAHGALIGARGNSGTILAQLLRGMAEVLTGDGDADHEAPDNAALLRRALRRAVESAYEGVARPVEGTVLTVASAAADAASTAATGDAAGVSRAAFDAAGTALAATPGQLEVLGRAGVVDAGGRGLVEVLGALAAALAGTEAAPHPPAGDSRHATRAWTAEACPADLGATTVTTGGEPDFEVIYLLEADDAAVARLRARLDALGESLVVVGGDGLWNVHVHVDDAGAAVEAGVEAGRPHRIRITHLATGTGLTRVREPAQRAVLALVPGEGLAALCAEAGATVVAVRPQEPPASGELVQAIRHAGVREVVLLPNDAELRHTAAAAAEQARAEGVRVALIPTRSPVQGIAALAVHEPGRRFDEDVVAMTSAAGATRHAELVVAERQSWTMAGVCQAGDVLGLIDGDVAVIGTDLAATAAVVLDRMLAAGGEMVTLVLGAGVPDEVADGLRRHVRRGHLAVDTVVYRGGQQAAPLLIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD19</accession>
    <name>A0A2G1XD19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23505</name>
        <name evidence="2" type="ORF">CYQ11_22565</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49059">
        <property type="protein sequence ID" value="PHQ49059"/>
        <property type="gene ID" value="BLA24_23505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15295">
        <property type="protein sequence ID" value="PPT15295"/>
        <property type="gene ID" value="CYQ11_22565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="75" mass="7807" checksum="CC79C3FE68386AD3" modified="2018-01-31" version="1">MQATAYTFDPSTRSGSVLLDDGTPVPFDAAAFDAGGLRLLRPGQRVRIECAQAPEGTAAGPAAGRRVTLVTLQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD46</accession>
    <name>A0A2G1XD46_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24025</name>
        <name evidence="3" type="ORF">CYQ11_22045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49142">
        <property type="protein sequence ID" value="PHQ49142"/>
        <property type="gene ID" value="BLA24_24025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15208">
        <property type="protein sequence ID" value="PPT15208"/>
        <property type="gene ID" value="CYQ11_22045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="20130" checksum="2A5F402C5E234F83" modified="2018-01-31" version="1">MAVTIDRTVTEEHAPSPPARLSLTPGSAPGLLDGAWWPRSRDLSRELPALAARLDHSWGRVTRVTVNPVFWPVIPRKVPVTGHTVHVGWFTNEQDPHKLLVFSYTADRLDLLIVPPETDPAAAARLMSAATTPGSLLTASRLMEDERAADDATESRDRQEEWETEGGTAPPPAGNPPGPPPSARGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDA3</accession>
    <name>A0A2G1XDA3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF3817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_24220</name>
        <name evidence="10" type="ORF">CYQ11_21855</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49175">
        <property type="protein sequence ID" value="PHQ49175"/>
        <property type="gene ID" value="BLA24_24220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15175">
        <property type="protein sequence ID" value="PPT15175"/>
        <property type="gene ID" value="CYQ11_21855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="110" mass="12100" checksum="67541608E5FB46F9" modified="2018-01-31" version="1">MKQSVLTRYRAMAYVTGVLLLLLTIGMIAKYGLDMDVSGPVRVIAIAHGWLFVVYLVFAFDMASKAKWPFGRLVWTLVAGTIPLAAFFVERKATRDLEPLVAAQAGPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDQ6</accession>
    <name>A0A2G1XDQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1003 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25330</name>
        <name evidence="4" type="ORF">CYQ11_20745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49373">
        <property type="protein sequence ID" value="PHQ49373"/>
        <property type="gene ID" value="BLA24_25330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14979">
        <property type="protein sequence ID" value="PPT14979"/>
        <property type="gene ID" value="CYQ11_20745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="189" mass="22450" checksum="510494E278F8B04C" modified="2018-01-31" version="1">MGAAERAEHRSEARERERERAHTPPRVRLDLPRPQRRTWLPEYDPEAFGRTSERIARFLGTGRFIVWMTVVIILWVVWNTSAPGHLRFDNYPFIFLTLMLSLQASYAAPLILLAQNRQDDRDRVNLEQDRKQNERSIADTEYLTREIAGLRMGLGEVATRDWIRSEFQELVKELEERRVFPEESEERDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDR5</accession>
    <name>A0A2G1XDR5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49345">
        <property type="protein sequence ID" value="PHQ49345"/>
        <property type="gene ID" value="BLA24_25170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="333" mass="34420" checksum="63C6FD8241086016" modified="2018-01-31" version="1">MLTGALAVAALVAALVALWQTQFGPLTRPDYCWGTWAQDGGPFHAGATHRTSSERAPTRRHPSGHCALSWRGGHGPKARDQRLDVRYDTGPEPADERRTWLAGLFTGGDSALPGGLPGFVTAASGSLVLPQTCDVKGLPSVLTISGTFADTAETARLLLQAADRAARVTGCAPRAAPRPGALPAAVAYAARAAAIAPGTAGCGIPALGREVRSAPAGRLTDRAGSLQDDFQTCAVASDSTWAARFTMTARPRIVALFAGLTGDGPPARGWRAHGRITPDGALVTADCAGRTTVFTMRSGPARTGTRLDDPREVFPDFVDAVAGRIGCAPLHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDZ1</accession>
    <name>A0A2G1XDZ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25835</name>
        <name evidence="2" type="ORF">CYQ11_20235</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49464">
        <property type="protein sequence ID" value="PHQ49464"/>
        <property type="gene ID" value="BLA24_25835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14886">
        <property type="protein sequence ID" value="PPT14886"/>
        <property type="gene ID" value="CYQ11_20235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13850" checksum="590390AA606250C7" modified="2018-01-31" version="1">MNANDWKLSVTGDNCPEWCSADHADEDPEHDSVFHESAPVAVELPPLINGERLRLAFVTTSSEAYRLPGEGRSPARVDLGTESDREGAVHDYVPVSSAETLDKLITDLRHAVSTLEQWRDRLPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE7</accession>
    <name>A0A2G1XEE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_26630</name>
        <name evidence="9" type="ORF">CYQ11_19005</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49600">
        <property type="protein sequence ID" value="PHQ49600"/>
        <property type="gene ID" value="BLA24_26630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14680">
        <property type="protein sequence ID" value="PPT14680"/>
        <property type="gene ID" value="CYQ11_19005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="28231" checksum="DEC54CE11C44BE6F" modified="2018-01-31" version="1">MNTLHSTTTSAVRTRLHDAGRSPEKSGAVGGRGCARGTGRGRPQYVYLTAAIDAIAYGEPKGGAPGGTGERGAQVPRTKASDAEEAFTAYVQERRASLYATAYHLTGDRHEAEDLLQSALFSTYRAWDRIADKAAIGGYLRRTMTNLHISAWRRRKLNEYPTEELPETVGEQDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIAEILDISVGTVKSSIWRSLRRLRDDEVICSGRVAEESFGELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEF8</accession>
    <name>A0A2G1XEF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26400</name>
        <name evidence="3" type="ORF">CYQ11_19240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49559">
        <property type="protein sequence ID" value="PHQ49559"/>
        <property type="gene ID" value="BLA24_26400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14721">
        <property type="protein sequence ID" value="PPT14721"/>
        <property type="gene ID" value="CYQ11_19240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="72" mass="7426" checksum="525CBE7ED371A98D" modified="2018-01-31" version="1">MMSASATLAALPLAAADLDKDKVTPGVLGFIVFAVIGGAVWLLMKSMNKHMKRVDFVEAPEPGAPGEGAADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI5</accession>
    <name>A0A2G1XEI5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26820</name>
        <name evidence="3" type="ORF">CYQ11_18815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49632">
        <property type="protein sequence ID" value="PHQ49632"/>
        <property type="gene ID" value="BLA24_26820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14647">
        <property type="protein sequence ID" value="PPT14647"/>
        <property type="gene ID" value="CYQ11_18815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="465" mass="47354" checksum="09AACDDD2B2B2486" modified="2018-01-31" version="1">MSALSVEMLAAAPTAPITSAGHAQLGAAVLVGIAVIVLLITRLKLHAFLSLTIGSLVLGAVAGAPLDKVITSFTTGLGSTVAGVGVLIALGAILGKLLADSGGADQIVDTILAKAGERSMPWAMVLIAGVIGLPLFFEVGIVLLIPVVLLVAKRGNQSLMRIGIPALAGLSVMHGLVPPHPGPLAAIDAIGADLGVTLALGVLVAVPTAVIAGPLFSRFAARWVDVAPPEKLIPQRPSEELERRPGFAVTVATVLLPVALMLVKALTDVVVDDPRDHVQRVADVIGSPLVALLTAVLVGMVTLGRAAGFRRDRLAGTVEKSLVPIAGILLIVGAGGGFKQTLIDVGVGRMILDVSKDWSVSALLLAWLIAVGIRLATGSATVATISAAGLVAPLAADMSTTHSALLVLAVGAGSLFFSHVNDAGFWMVKEYFGMGVGQTIKTWSLMETVISVVGLGFVMALSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEM6</accession>
    <name>A0A2G1XEM6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27060</name>
        <name evidence="7" type="ORF">CYQ11_18570</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49672">
        <property type="protein sequence ID" value="PHQ49672"/>
        <property type="gene ID" value="BLA24_27060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14605">
        <property type="protein sequence ID" value="PPT14605"/>
        <property type="gene ID" value="CYQ11_18570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="43"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="31572" checksum="728B8D4F2AF840FB" modified="2018-01-31" version="1">MTLATSRHTTRHATKHAAKRSERDEAGTGTGTGEGAAGVVPAVRIDRVHKGFGRSGGGRPVLEDISLDVRPGEFVCILGASGCGKSTLLNLVAGLDRPTSGTIDVPGGRPALMFQEHALFPWLTAGRNIELALRLRGVPRTERRTEAERLLDLVRLGGSHGKRVHELSGGMRQRVALARALAQDSRVLLMDEPFAALDAITRDVLHHELTRVWSQTRLSVLFVTHNVREAVRLGQRVVLLSSRPGKIVREWTVDIPQPRRIEDTTVADLSIEITEELRKEIRRHGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEQ2</accession>
    <name>A0A2G1XEQ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_23855</name>
        <name evidence="15" type="ORF">CYQ11_22215</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49703">
        <property type="protein sequence ID" value="PHQ49703"/>
        <property type="gene ID" value="BLA24_23855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16722">
        <property type="protein sequence ID" value="PPT16722"/>
        <property type="gene ID" value="CYQ11_22215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="83"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="341"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ49703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT16722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="497" mass="54807" checksum="D49A335633E96457" modified="2018-01-31" version="1">MAFPRSIRKHGTRDGRARRSGAIRTPLPRRISVRLLALLTAAASTWVMSPAPAPSLAALPEAGLPGVGDSYFPGLGNGGFDVRHYDLDVRYAPDSGRLDGRTTITARATRPLSSFDLDLQRLDVASVEVNGIPAGFRRDGDELRVHPVIPLPKGRTFTTTVTYGGVPEPLGGPVVFGSRYGWMKTKDGAFVACEPNAASTWFPSSDHPSDKATFDIRIRAPKGLTAISNGRLLATSAHGATTVTHWRENKPMAPYLATATIGKFDVKRGTTPGGTPLYVATDPTLAAGKLDMYALTAEATDHWSRVFGPYPFEETGAIIDDVPQADFSLEAQTKPLFSAVRDESTVVHELAHQWFGDSVSVERWKDIWLNEGFATYAEWLWDEHKGRKSAHQSFLEAYDLHHADDPFWKVVVADPQRETMLSRAVYYRGAMTLQMLRERIGDRAFFRLLPRWTKLHRHGNARTAQFTALAEAVSHKDLGDLFTTWLHTPGKPALPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF85</accession>
    <name>A0A2G1XF85_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase BLA24_19825</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_19825</name>
        <name evidence="8" type="ORF">CYQ11_10965</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49887">
        <property type="protein sequence ID" value="PHQ49887"/>
        <property type="gene ID" value="BLA24_19825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13337">
        <property type="protein sequence ID" value="PPT13337"/>
        <property type="gene ID" value="CYQ11_10965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="417" mass="45187" checksum="DA9AFE98239158A2" modified="2018-01-31" version="1">MEIRPTTDKDLDVFVDTLHAAFGRFPETPAEDGGGLWWSALETDRSLLAVAADGRPVGTASAYSFELTLPGEALVPAAGVTGVGVLPSHRRQGVLTAMMRHQLVELRSRGEFLSVLLASEALIYRRFGYGPATYAQQLTVARHQAAFARPRARGTAGIPATGSDAGPDAGSDTGSVELLRRAECGGILEEVYDRYRRAQPGALSRPHRWWALGAGQPPVSSAPRHVAVHRDPDGVPDGYASYSVESNTLTVDETIATDDAAFTALARFVLGHDLVTQVVFKRLPPEHPLRWQLEDFRAGQVSDDDWLWVRLLDVPRALTARGWCADGELVLDVDDPFLGEHGRYLLTVRGGEADCVPTDREPDLSLDVSDLGSVYLGGTTPSTLVRAGHVRAHRPGAAALADALFRAERPPHCLHWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFF7</accession>
    <name>A0A2G1XFF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20365</name>
        <name evidence="3" type="ORF">CYQ11_10420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49974">
        <property type="protein sequence ID" value="PHQ49974"/>
        <property type="gene ID" value="BLA24_20365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13249">
        <property type="protein sequence ID" value="PPT13249"/>
        <property type="gene ID" value="CYQ11_10420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="86" mass="8873" checksum="0A7911B8A4E89166" modified="2018-01-31" version="1">MSAVAHRGREPAESVLRVVRGDPDAAQLAAATVALLAALRGRAGGDGAGDGRRRPARWRPPVAYEPPGAWGSGMGRQYGGSLRGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFL6</accession>
    <name>A0A2G1XFL6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pepN</name>
        <name evidence="16" type="ORF">BLA24_20620</name>
        <name evidence="17" type="ORF">CYQ11_10160</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50017">
        <property type="protein sequence ID" value="PHQ50017"/>
        <property type="gene ID" value="BLA24_20620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13205">
        <property type="protein sequence ID" value="PPT13205"/>
        <property type="gene ID" value="CYQ11_10160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="231"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="535"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ50017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="857" mass="94419" checksum="C5E893587AF30B0F" modified="2018-01-31" version="1">MPGTNLTREEAQQRARLLSVDSYEIDLDLSGAQEGGTFRSVTTVRFDVSEAGADSFIDLVAPAVHEVVLNGAALDAAEVFADSRIALPGLKAGRNDLTVVADCAYTNTGEGLHRFVDPVDQQAYLYTQFEVPDARRVFASFEQPDLKATFQFTVKAPEGWTVVSNSPTPKRPADNVWRFEPTPRISTYITALIAGPYHAVHSTYEKDGQTVPLGIYCRPSLAEFLDADAIFDVTRQGFDWFQEKFDYAYPFAKYDQLFVPEFNAGAMENAGAVTIRDQYVFRSKVTDAAYEVRAETILHELAHMWFGDLVTMEWWNDLWLNESFATYTSIACQAYAPGSKWPHSWTTFANSMKTWAYRQDQLPSTHPIMADIRDLDDVLVNFDGITYAKGASVLKQLVAYVGMDEFFTGVQAYFKEHAFGNTRLSDLLGALEKTSGRDLSTWSRKWLETAGINVLRPEVTTDAAGVITAFAVRQEAPALPAGAKGEPTLRPHRIAIGLYEHEDGKLVRKDRVELDVDGELTEVPQLVGRARPAVVLLNDDDLSYAKVRLDAESLATVTQHLGDFAESLPRALCWASAWDMTRDGELATRDYLDLVLSGVAKESDIGVVQSLQRQVKTAIDLYAAPTWRETGLAKWTEATLEHLRAATPGSDHQLAWARAFAATARTDEQLALLAGLLDGSESIEGLAVDTELRWDLLGRLAATGRADEKAIAAELERDKTSAGEEHAAWARAARPTAEAKAEAWASVVDSDKLPNAVQESVIGGFQQSDQRELLAPYAEKYFAVVKDVWEKRSHEMAQQIAVGLYPLLQVSQETLDATDAWLASAEPNAALRRLVTESRAGVERALRAQAADAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFM2</accession>
    <name>A0A2G1XFM2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BLA24_20700</name>
        <name evidence="19" type="ORF">CYQ11_10080</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50033">
        <property type="protein sequence ID" value="PHQ50033"/>
        <property type="gene ID" value="BLA24_20700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13189">
        <property type="protein sequence ID" value="PPT13189"/>
        <property type="gene ID" value="CYQ11_10080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="17">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="16">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PHQ50033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PPT13189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="29379" checksum="13CD203DD14B7226" modified="2018-01-31" version="1">MPEGHTIHRLAADHRDLFAGRPVRASSPQGKFADGAALIDGRVFETAEAHGKHLFLGFAGTGWVHVHLGLFGKYTLGGGQAPPPTETVRLRLASPDAHADLRGPTACALITDAEKQAVHDRLGPDPLRPEHDGEAAYARVSRSRSSVAALLMDQKVVAGVGNVYRAEVLFRHGVDPYRAGRDLTRAEWDAIWADLVELMREGVRNNRIDTVRPEHTPEAMGRPPRVDDHGGEVYVYRRAGMPCHVCGDAIRTAGLAARNLFWCPECQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFT7</accession>
    <name>A0A2G1XFT7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21160</name>
        <name evidence="3" type="ORF">CYQ11_09625</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50102">
        <property type="protein sequence ID" value="PHQ50102"/>
        <property type="gene ID" value="BLA24_21160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13117">
        <property type="protein sequence ID" value="PPT13117"/>
        <property type="gene ID" value="CYQ11_09625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="21518" checksum="BD74438A7A42B206" modified="2018-01-31" version="1">MYAISLGDDGAELRPLEPWQAEEFLAHVRRGRDFVGRFLPLSEVVWDLESSRAYLRSYAQKAATDTGRIHGIWADGQLVGVVLIRSMDVGQGVAEVGCWLEPSAVGKGLITRAARSVIDWAVEQRGIHRVEWQAATANTASIAVARRLGMTKEGVQRESFPLRGERYDMELWSVLAPEWRAARAAAATAAVAASMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGA9</accession>
    <name>A0A2G1XGA9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">npdG</name>
        <name evidence="2" type="ORF">BLA24_22250</name>
        <name evidence="3" type="ORF">CYQ11_08535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50278">
        <property type="protein sequence ID" value="PHQ50278"/>
        <property type="gene ID" value="BLA24_22250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12936">
        <property type="protein sequence ID" value="PPT12936"/>
        <property type="gene ID" value="CYQ11_08535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="24591" checksum="7BFBE83D6250E7ED" modified="2018-01-31" version="1">MTTSEEPKKAPAKDPWDLPDVSGLVVGVLGGTGDQGRGLAYRLAKAGQRVIIGSRAAGRAQAAADELGLGVEGADNAECARRSDIVIVAVPWDGHAETLRSLREELAGKLVVDCVNPLGFDKQGAYALKPEEGSAAEQAAALLPGSRVTAAFHHLSAVLLSDPEIAEIDTDVMVLGEKRADTDVVQALAGRIPGMRGVFAGRLRNAHQVESMVANLISMNRRYKAHAGLRVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGE4</accession>
    <name>A0A2G1XGE4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22410</name>
        <name evidence="3" type="ORF">CYQ11_08375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50306">
        <property type="protein sequence ID" value="PHQ50306"/>
        <property type="gene ID" value="BLA24_22410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12907">
        <property type="protein sequence ID" value="PPT12907"/>
        <property type="gene ID" value="CYQ11_08375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="16346" checksum="A4852FC9816D344A" modified="2018-01-31" version="1">MTEPCELVRLLDLQPHVEGGWFRETWQTAGATVPDGYAGPRAYATGIYFLLHPGEVSRWHRVRSDEMWLWHRGGPLRLRLGGTGERPDEAGAADVVLGSGVERGERPQVLVPGGVWQSAEPVGTEPALVTCVVAPGFHYEDFTLAGEPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGI0</accession>
    <name>A0A2G1XGI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22465</name>
        <name evidence="3" type="ORF">CYQ11_08325</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50315">
        <property type="protein sequence ID" value="PHQ50315"/>
        <property type="gene ID" value="BLA24_22465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12898">
        <property type="protein sequence ID" value="PPT12898"/>
        <property type="gene ID" value="CYQ11_08325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="118" mass="12336" checksum="E88124BAF52719D6" modified="2018-01-31" version="1">MRQIPVDTSAASVMVAKPPQPKLKDRRTGERAVDAETGAPLSVVDVMFAANDEVEILSVAVPETGVSGELVMGTPVALTGLVARPWENEFNGQKRHGISFRAVAVTSLVAGATKPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGJ0</accession>
    <name>A0A2G1XGJ0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glutamine synthetase</fullName>
            <ecNumber evidence="9">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glnA</name>
        <name evidence="11" type="ORF">BLA24_22530</name>
        <name evidence="12" type="ORF">CYQ11_08260</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50325">
        <property type="protein sequence ID" value="PHQ50325"/>
        <property type="gene ID" value="BLA24_22530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12888">
        <property type="protein sequence ID" value="PPT12888"/>
        <property type="gene ID" value="CYQ11_08260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="10">
        <location>
            <begin position="101"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="6">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="469" mass="52430" checksum="1124B5646D19E4DD" modified="2018-01-31" version="1">MFQNADEAKKFISDEDVKFVDVRFCDLPGVMQHFTIPASAFDPTEELAFDGSSIRGFQAIHESDMALRADLSTARMDPFRRDKTLNINFFIHDPITGEQYSRDPRNIAKKAEAYLASTGIADTAYFGPEAEFYVFDSVRFETSANQSFYHIDSEAGAWNTGALEDNRGYKVRYKGGYFPAPPVDHFADLRAEISLELDKAGLQVERQHHEVGTAGQAEINYKFNTLLAAADDLMLFKYIVKNVAWRNGKTATFMPKPIFGDNGSGMHVHQSLWSNGEPLFYDEQGYAGLSDTARYYIGGILKHAPSLLAFTNPTVNSYHRLVPGFEAPVNLVYSQRNRSAAMRIPITGANPKAKRVEFRAPDPSSNPYLAFSALLLAGLDGVKNKIEPAEPIDKDLYELAPDEHAGVPQVPTSLPAVLEALEADNEYLQAGGVFTSDLIETWIDYKRTNEIAPIQLRPHPHEFEMYFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGJ1</accession>
    <name>A0A2G1XGJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22150</name>
        <name evidence="2" type="ORF">CYQ11_08635</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50259">
        <property type="protein sequence ID" value="PHQ50259"/>
        <property type="gene ID" value="BLA24_22150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12955">
        <property type="protein sequence ID" value="PPT12955"/>
        <property type="gene ID" value="CYQ11_08635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="9283" checksum="88959B5DE2083C7F" modified="2018-01-31" version="1">MVRSHALPRERVEHVAVHAHAEPHPVLGVYLLAERLEQAELHAAQACRRTIAHRPELAEWELATAQVPLLDLHGPLELSPLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGW1</accession>
    <name>A0A2G1XGW1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16670</name>
        <name evidence="2" type="ORF">CYQ11_16615</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50473">
        <property type="protein sequence ID" value="PHQ50473"/>
        <property type="gene ID" value="BLA24_16670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14272">
        <property type="protein sequence ID" value="PPT14272"/>
        <property type="gene ID" value="CYQ11_16615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="20596" checksum="2D31DA1948182806" modified="2018-01-31" version="1">MPTHVIEKDFSDERATLLAFLEAQRGGLRRALLGLTEEQAAAKPSASELSLGGLLKHVAETEQGWVRRAQGLPPAVERDEKTWSDSFRLTGDETVKGQLAHWAAVAAETERFIYSVQSLEENFALPEAPWFPKARVSMRWLVLHLIEETARHAGHADVIRESLDGKTAFALVDEERRAAEAAAQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH35</accession>
    <name>A0A2G1XH35_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16505</name>
        <name evidence="6" type="ORF">CYQ11_16780</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50449">
        <property type="protein sequence ID" value="PHQ50449"/>
        <property type="gene ID" value="BLA24_16505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14299">
        <property type="protein sequence ID" value="PPT14299"/>
        <property type="gene ID" value="CYQ11_16780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="35848" checksum="D8758B7047F890C7" modified="2018-01-31" version="1">MASGTRTWREAAQAALYGPDGFYRRPEGPAGHFRTSVHASPLYARAVADLLCRVDAALGHPAELAFTDMGAGRGELVTGVLAHCPAELTERLRPYAVEIAARPAGLDPRVIWLDTPPDGVTGLFFANEWLDNVPLDVAEADGDGTARQVLVRPDGEELLGDPVAGEDAAWLAGWWPLEGAPPGSRAEIGRPRDAAWAGAVAGLRAGLAVAVDYAHARASRPPMGTLTGFRDGREVRPVPDGSCDITAHVALDACAAAGADHGPAGSLISQREALRALGVDGGRPPLSLASTDPVAYVRALGRAGEAAELTAPGGLGGFGWLLQPVGAACADLVADGPAGPPSEGRDPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH39</accession>
    <name>A0A2G1XH39_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="7" type="ORF">BLA24_17080</name>
        <name evidence="8" type="ORF">CYQ11_16195</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50535">
        <property type="protein sequence ID" value="PHQ50535"/>
        <property type="gene ID" value="BLA24_17080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14211">
        <property type="protein sequence ID" value="PPT14211"/>
        <property type="gene ID" value="CYQ11_16195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="760" mass="77631" checksum="BC85D1A67CC20371" modified="2018-01-31" version="1">MSSLALYRRYRPESFAEVIGQEHVTTPLQQALRNNRVNHAYLFSGPRGCGKTTSARILARCLNCEQGPTPTPCGECQSCLDLARNGRGSIDVIEIDAASHGGVDDARELREKAFFGPASSRYKIYIIDEAHMVTSAGFNALLKVVEEPPEHLKFIFATTEPEKVIGTIRSRTHHYPFRLVPPGTLRDYLGEVCEQEKIPVEDGVLPLVVRAGAGSVRDSMSVMDQLLAGAAEDGVTYAMATSLLGYTDGSLLDAVVEAFAAGDGAAAFEVVDRVIEGGNDPRRFVADLLERLRDLVILAAVPDAAEKGLIDAPVDVIERMQAQASVFGAAELSRAADLVNQGLTEMRGATSPRLQLELICARVLLPAAFDDERSVRARLDRLERGAAAGALAGGVAAGVPAGGAVGYVPGPEAHAPVVEPGAGLSGAAAARAAVSGTGVPTAAAPPAPVAQAPAAPAPAAPEPVQPPVAPGGSRPGAWPMAATPGQQPPEQPATPQAGAWPTAAASPAASTSALTPASAPQTGAWPTAATPAPAQTPAAPAAGPGSGGPQGDATQARQLWPNILEAVKNRRRFTWILLSQNAQVAGCDGTTLQVGFSNAGARDSFANSGSEDVLRQALGDLGLPWKTELLVDPSGGGNPPGGGATPPGGGFGGGMGGGFGGGAPAAPPAAPAYARPQTPAPAPAPQQAPPGPAPEARPAQSAPPAAGPSQQYRQPEPPPVPIEDDVPAEDDPDLDDTALTGHDLIVRELGATVIEEIANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHD9</accession>
    <name>A0A2G1XHD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17730</name>
        <name evidence="3" type="ORF">CYQ11_15545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50637">
        <property type="protein sequence ID" value="PHQ50637"/>
        <property type="gene ID" value="BLA24_17730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14108">
        <property type="protein sequence ID" value="PPT14108"/>
        <property type="gene ID" value="CYQ11_15545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="105" mass="11561" checksum="CA01B9628D6D02AD" modified="2018-01-31" version="1">MKAFRLDELEAERAANEGAYLQFLRERNMSMGLYALDAGDQDPQAPHAQDEVYVVVSGRASITVGTETTEVGRGSVVYVPAGVTHRFHHISEDLRVLVVFSPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHS4</accession>
    <name>A0A2G1XHS4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="7" type="ORF">BLA24_18685</name>
        <name evidence="8" type="ORF">CYQ11_14595</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50798">
        <property type="protein sequence ID" value="PHQ50798"/>
        <property type="gene ID" value="BLA24_18685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13944">
        <property type="protein sequence ID" value="PPT13944"/>
        <property type="gene ID" value="CYQ11_14595"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="6">
        <location>
            <begin position="230"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="520" mass="55166" checksum="DCE37A92B0057A48" modified="2018-01-31" version="1">MVPRPVPARLPVPAELGRLLVLTTVFICAACGLVYELELVALASYLIGDSVTQASVVLSVMVFAMGVGSLLAKRLRARAALGFAAIEAVLALTGGLSAMALYACFAWFGQARLALVGFSLAIGVLIGAEVPLLMTLIQRIRRQDAGGAVADLFAADYVGALVGGLAFPFLLLPVLGQLTGALVTGAVNAVAGGVLVLWLFRRDLTVRALWLLVAVNALVLALLGVCSALTGPFERAARQAVYGAEVKVAVHSDVQEVVLTGGGASGQPLSLFLDGRLRVSGNDDCRYHEALVHPAMAGPHRRVLVLGGGDGLAVREVLRYPDVASVTVVEEDAAVLRLARADRDLVALNGAAYRDPRVRVVTADAFDWLRSSRGQEAGPYDVVVSDLPDPGVTPSAKLYSQEFYGLVTRSLAPGGRLAIHGGDLSARPHTFWTVDATVRSVGLATEPYRVMAPPARDTRRQDWGLLLASRSPAPLRLPEARPALRTLTPHRLRRLAWAAERGRQPSPPPSTLMHPRYGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHS8</accession>
    <name>A0A2G1XHS8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="3" type="ORF">BLA24_18730</name>
        <name evidence="4" type="ORF">CYQ11_14550</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50804">
        <property type="protein sequence ID" value="PHQ50804"/>
        <property type="gene ID" value="BLA24_18730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13938">
        <property type="protein sequence ID" value="PPT13938"/>
        <property type="gene ID" value="CYQ11_14550"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="31823" checksum="8BDFE91D0F1F2E76" modified="2018-01-31" version="1">MPHPQSPVPETGPEAVPAPNLDFESTTPYEDYIRASVLSQLQHPRSDDPGEMVFIVTTQVMELWFTVLVHEWETAARALREDALPVAMAALKRSVHELRSLNASWEPIAHLTPAQFNGYRSALGEASGFQSATYRRLEFLLGDKSASMLVPYRNVPRVHDELEKALHAPSLYDEVLRWLARRGHAVPAAVLERDVAERHTGDPGVEDVWQRVYAGDQDSEECRLGEALTEVAEQVWRWRNDHLVATRRAMGSKVGTGGSGGVAWLEKRAAKNVFPELWTARSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHV7</accession>
    <name>A0A2G1XHV7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_18775</name>
        <name evidence="6" type="ORF">CYQ11_14505</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50813">
        <property type="protein sequence ID" value="PHQ50813"/>
        <property type="gene ID" value="BLA24_18775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13929">
        <property type="protein sequence ID" value="PPT13929"/>
        <property type="gene ID" value="CYQ11_14505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="243" mass="26709" checksum="57C29500A668C3DD" modified="2018-01-31" version="1">MPGSDPVKRTTLRSQIADALREEVIAGRLPAGRQFTVKEIAEQYGVSATPVREALLDLCSQGLLDVELHKAYRVREFSYADFRDMVEARTLIVEGMFRRSAERALLSATPESLGSVRRRAEEAGRAALAGDLDILIGYDLRFWREMAGLVGNPYISDFLDRVRVQSWVFTVPLLRRLDDLRGRLWHRHTELVEAVAGRDVARAQRIIVEYNAHTLALVDGLSGAAAGGAGRSPGSPAEGPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI13</accession>
    <name>A0A2G1XI13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18515</name>
        <name evidence="4" type="ORF">CYQ11_14765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50769">
        <property type="protein sequence ID" value="PHQ50769"/>
        <property type="gene ID" value="BLA24_18515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13973">
        <property type="protein sequence ID" value="PPT13973"/>
        <property type="gene ID" value="CYQ11_14765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="22088" checksum="2A3B6D7E05C9AFAD" modified="2018-01-31" version="1">MASSPQARKSDTRERIQKTALDLFVSRGYDKTSLREIAEELGVTKAALYYHFKTKEDILGALSDQLGRPVDDLIAWAREQPVTLETKRELLRRYSTALRDAAPIYHVFQENQATLRELSIGEALQERLVAVTALLQAGTDRSPDAQVRFSSAMLTVHFGAFTLNGLAGEAEEKREALLRVALEILDSTDDARGEEPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI28</accession>
    <name>A0A2G1XI28_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdhA</name>
        <name evidence="5" type="ORF">BLA24_18230</name>
        <name evidence="6" type="ORF">CYQ11_15045</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50898">
        <property type="protein sequence ID" value="PHQ50898"/>
        <property type="gene ID" value="BLA24_18230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14023">
        <property type="protein sequence ID" value="PPT14023"/>
        <property type="gene ID" value="CYQ11_15045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="67"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="389" mass="42444" checksum="E0D98ABAF1CC995C" modified="2018-01-31" version="1">MTVLEQPGSYRPTPPPAWQPRTDPVPLLPDAEPFRLLGTEAAAELDPQLLLRLYGQLVRGRRYNTQATALTRQGRLAVYPSSTGQEACEVAAALALEERDWLFPSYRDTLAAIVRGLDPVQALTLLRGDWHTGYDPHEHRVAPLCTPLATQLPHAVGLAHAARLKGDDVVALAMVGDGGTSEGDFHEALNFAAVWRAPVVFLVQNNGFAISVPLAKQTAAPSLAHKAVGYGMPGRLVDGNDVAAVHQVLSEAVARARAGGGPTLVEAVTYRIDAHTNADDATRYRTDAEVETWRAHDPVDLLRRELTGRKLLDEATIRAEQDAAERMAADLRERMNQDPELDPMELFSHVYTQQTAQLREQAAQLRAELTAAGELPAAQEGRPQEGRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI41</accession>
    <name>A0A2G1XI41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-beta hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18695</name>
        <name evidence="3" type="ORF">CYQ11_14585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50799">
        <property type="protein sequence ID" value="PHQ50799"/>
        <property type="gene ID" value="BLA24_18695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13943">
        <property type="protein sequence ID" value="PPT13943"/>
        <property type="gene ID" value="CYQ11_14585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="22528" checksum="D06E3AAA9D993FF3" modified="2018-01-31" version="1">MVRIALFGATGTIGSRVLREALERGHQVTAVVRDPAKLTERHPGLKVTTGDVLDPASVAAAAEGQDVVVSAVGGGDGPGHVATIEPAAKSLVAGVRSLGAMAPRLIAVGGAGSLRTPAGTKVWDAEGIPEFLLQIMHAHGDALDYYRTVSDVRWTNLSPAGTIEPGERTGAYRTALEDLVVDEQGVSRISAEDYAVALVDEIETPKHVGERFTVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI87</accession>
    <name>A0A2G1XI87_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uma2 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14110</name>
        <name evidence="3" type="ORF">CYQ11_13965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50930">
        <property type="protein sequence ID" value="PHQ50930"/>
        <property type="gene ID" value="BLA24_14110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13850">
        <property type="protein sequence ID" value="PPT13850"/>
        <property type="gene ID" value="CYQ11_13965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="191" mass="21546" checksum="70B0440F9C33FF1B" modified="2018-01-31" version="1">MAAVRDSAELDRMFDDLEHLNLPADYRVEIIEGEIIMNPQRKVHSKIIQLLTMALTDALGRKANILWDVRVDFPGYLNGFAPDVALVKDGAEEDEAGNHDYRDVEFVAEVVSRGSRRADYEAKLNVYAVAGVPTYLIADPKSGLVHVHHDPREGKYTDEVVYTFGSTFTLPYPEVTIDTSDWPRDHRASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XID9</accession>
    <name>A0A2G1XID9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ORF">BLA24_14640</name>
        <name evidence="12" type="ORF">CYQ11_13430</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956479.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51018">
        <property type="protein sequence ID" value="PHQ51018"/>
        <property type="gene ID" value="BLA24_14640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13759">
        <property type="protein sequence ID" value="PPT13759"/>
        <property type="gene ID" value="CYQ11_13430"/>
    </dbReference>
    <dbReference type="GeneID" id="61470280"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="15222" checksum="2BAF53D4C7640730" modified="2018-01-31" version="1">MPPKKKKVTGLIKLQIQAGAANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGMVVPVEITVYEDRSFTFVTKTPPAAKLILKAAGVDKGSGEPHKTKVAKLTRDQVRDIATTKMPDLNANDLDAAEKIIAGTARSMGITVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG3</accession>
    <name>A0A2G1XIG3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">BLA24_14515</name>
        <name evidence="15" type="ORF">CYQ11_13560</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51000">
        <property type="protein sequence ID" value="PHQ51000"/>
        <property type="gene ID" value="BLA24_14515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13778">
        <property type="protein sequence ID" value="PPT13778"/>
        <property type="gene ID" value="CYQ11_13560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ51000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="31193" checksum="95C913FA21493ED9" modified="2018-01-31" version="1">MHRRHNGLRTAVLLGGLSALIIVIGSVFGRTGLIVAVLVALGTNAYAYWNSDKLALRAMRARPVSEFEAPQLYRMVRELSTAARQPMPRLYISPTEAPNAFATGRNPRNAAVCCTEGILRLLDERELRGVIGHELSHVYNRDILISSVAGALASVVMFLVNFAWLIPFGRSDDDEGPGIFGMIMIMLLGPVAASLIQLAVSRSREYEADASGARLTGDPLALAAALRKLEAGTQRLPLPPEPRLETASHMMIANPFRAGEGMTKLFSTHPPMTERISRLERMAGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIH6</accession>
    <name>A0A2G1XIH6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">BLA24_14840</name>
        <name evidence="9" type="ORF">CYQ11_13230</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51054">
        <property type="protein sequence ID" value="PHQ51054"/>
        <property type="gene ID" value="BLA24_14840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13723">
        <property type="protein sequence ID" value="PPT13723"/>
        <property type="gene ID" value="CYQ11_13230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="14120" checksum="83EFA8F84CBF051C" modified="2018-01-31" version="1">MARVSGVDIPRDKRVEVALTYVFGIGRTQSKATLAATGVNPNTRVRDLSEEDLVKIREHVDANLKTEGDLRREIQADIRRKVEIGCYQGLRHRRGLPVHGQRTSTNARTRKGPRRAIAGKKKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIR6</accession>
    <name>A0A2G1XIR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15240</name>
        <name evidence="4" type="ORF">CYQ11_12830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51126">
        <property type="protein sequence ID" value="PHQ51126"/>
        <property type="gene ID" value="BLA24_15240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13652">
        <property type="protein sequence ID" value="PPT13652"/>
        <property type="gene ID" value="CYQ11_12830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="107"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="409" mass="44915" checksum="163091ED36920820" modified="2018-01-31" version="1">MASFPKIISVDDHVVEPSDVWRDRLPARLRDVGPRVVRAAVKEMTFVGGRFAPVMGAPGDDGPVADWWVYEDLCRPLTRLDTAVGCSRDEIRLEGITYERMRPGSYSVAERLADMDLNHVQSALCFPTFPRFCGQTFAEAADRELALLCVRAYNDWMVEEWCGPAAQGRLIPLGLVPLWDAGLAAAEVRRNAARGVRAVCFSEIPPHLGLPSVHGDDWDPFLRACEESGTVIAMHIGSSSRMPSTSADAPAAVGSALTFANCCFSLADWLMSGKFDRFPGLRVMYAEGQIGWIPYLLERADTVWEENRGWGGVADKVLRPPSEAFAEHVYGCFFDDAFGLRNLDAIGVGNVLYETDYPHSDSTWPKSRQVAEEQMAHLAPEVVERVVRGNAVELLGLTPEGLWAGGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIZ6</accession>
    <name>A0A2G1XIZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_15740</name>
        <name evidence="8" type="ORF">CYQ11_12335</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51206">
        <property type="protein sequence ID" value="PHQ51206"/>
        <property type="gene ID" value="BLA24_15740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13570">
        <property type="protein sequence ID" value="PPT13570"/>
        <property type="gene ID" value="CYQ11_12335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="678" mass="71215" checksum="B02808F6309F8496" modified="2018-01-31" version="1">MTTTTPAPQAPPAPPVLSRRRTNLVFVTIVLGMLLAALDQTIVSTALPTIVADLGGGGHMAWVVTAYLLAETVSTVLVGKFGDLFGRKVVFQLSAVVFVGGSVFAGAATSMPMLVAARAVQGVGGGGLMVTAMALIADVIPLRERGKYQGALGAVFGVTTVVGPTLGGVFTDHATWRWCFYVNVPVAIVMVVMAARTVPAVRPAVRPVIDYPGIVLVALGSSALVLGLEWGGNRYAWSSPVVVALFAAAAVLLAAFVAVERRAAEPMLPMHLFRTPVFTVCSVLSFIVGFAMLGSMTYLPTYLQFVDGDSATLSGVRALPLVAGLLGASMISGTVVGHTGRYRVFPIAGTAVMALGLFLMSTMGASTGVWLESLYMCVLGVGLGFAMQVLTIAVQNTVPYHELGSATSGVTFFRTLGSAFGTAIFGTLYTNQLVPNLRDALARAPGVPLSAVQSPQALAALPAAQARPVVDAYAATVNYVFLWIVPVALVGFVAAWFLREVPLRDSARAGASDLGEAFSAPDSAEADRQLERAVASVLRKAGAVPVGRGVLARSGSALDPVLAWTLGQIHWRLRVRGEATLSSVATAHRMPPEVLEPAFARAAGAGYARIEGDRLFLTPAGESEVARLATAWRAWLAARLDDWDLTDGEDRARLDRALDVIAERLLEEDEHAQERLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ63</accession>
    <name>A0A2G1XJ63_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">glmU</name>
        <name evidence="18" type="ORF">BLA24_15915</name>
        <name evidence="19" type="ORF">CYQ11_12160</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51240">
        <property type="protein sequence ID" value="PHQ51240"/>
        <property type="gene ID" value="BLA24_15915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13536">
        <property type="protein sequence ID" value="PPT13536"/>
        <property type="gene ID" value="CYQ11_12160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="17">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="262"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="396"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PHQ51240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PPT13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="484" mass="50183" checksum="3963DE93F2C772F8" modified="2018-01-31" version="1">MSANRPAAVVVLAAGEGTRMKSATPKVLHEICGRSLVGHVVAAARELGPEHLVVIVGHAREQVSAHLAAIDPGVRTAVQYEQNGTGHAVRMGLEELSNSGIALDGTVVVVCGDTPLLTGETLERLAGTHAADGNAVTVLTAEVPDSTGYGRIVRDDDGAVTAIVEHKDASDAQRAIREINSGVFAFDAQLLTDALGKVRTDNSQGEEYLTDVLGILREAGHRVGAAVAGDHREILGINNRVQLAEARRLLNERLLHAAMMSGVTVVDPATTWVDVTVTFEPDALVQPGTQLLGATHLATGSEVGPNTRLKDTAVGAGARVDNTVADSALIGEGASVGPYAYLRPGTRLGPKSKAGAYVEMKNAEIGEGTKVPHLSYVGDATIGEYSNIGAASVFVNYDGVNKHHTTIGSHCRTGSDNMFVAPVTIGDGAYTAAGSVITKDVPPGSLAVARGQQRNIEGWVARKRPGSAAAQAASAARRDPDGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ99</accession>
    <name>A0A2G1XJ99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14395</name>
        <name evidence="4" type="ORF">CYQ11_13680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51334">
        <property type="protein sequence ID" value="PHQ51334"/>
        <property type="gene ID" value="BLA24_14395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16543">
        <property type="protein sequence ID" value="PPT16543"/>
        <property type="gene ID" value="CYQ11_13680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="137"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="417" mass="46267" checksum="2C8AD7684140AA46" modified="2018-01-31" version="1">MASRIAPVAADRSVPGLIVKIGDYPLHHGGVGAIRSLGRLGVPMYAVTEDRWTPAAVSRYLSSCFVWPTTGSERPGELVAGLLRIGREIGRPTVLIPTDEEAAVLIAENAGELAGPFLFPPVERGLPRRLASKQGLHELCVEHGVPSPSALFPASYEEIEKYASVATFPLVAKNREAFERRRHPAVHGTTRIHGPRELLALARDWGPAPGVILQEYLPREQAEDWIVHAYFDAESTPMAMFTGVKVRSWPPHAGMTANAYIVDNPELAAMAAQFIKQIGFCGIVDLDWRFDRRDGRYKLLDFNPRMGAQFRMFENEAGIDVVRAQHLDLTGRAVPEGEQLAGRRFVVENIDLPALAAYRRSGYTTPHAPARANGTELAWAARDDMKPFFTMLARFVRPGARHLWQLWRSRRRSAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJJ2</accession>
    <name>A0A2G1XJJ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="5">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_16095</name>
        <name evidence="16" type="ORF">CYQ11_11980</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51370">
        <property type="protein sequence ID" value="PHQ51370"/>
        <property type="gene ID" value="BLA24_16095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16507">
        <property type="protein sequence ID" value="PPT16507"/>
        <property type="gene ID" value="CYQ11_11980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="336"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ51370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="464" mass="49443" checksum="18125FD4F06679D5" modified="2018-01-31" version="1">MQYHDSMIELVGNTPLVKLNSVTEGVQATVLAKVEYFNPGGSVKDRIALRMVEAAEKSGELKPGGTIVEPTSGNTGVGLAIVAQQKGYKCIFVCPDKVSQDKINVLRAYGAEVVVCPTAVDPEHPDSYYNVSDRLVRETPNAWKPDQYSNPNNPLSHYHSTGPELWEQTEGKITHFVAGVGTGGTISGTGRYLKEVSEGRVQVIGSDPEGSVYSGGSGRPYLIEGVGEDFWPTAYDGSVPDEIVAVSDKDAFQMTRRLAKEEGLLVGGSCGMAVVSALRVAERLGPDDVVVVLLPDSGRGYLSKIFNDEWMADYGFLEEAGDAARVGDVLRRKDGDLPSLVHMHPEETVGQAIEVLREYGVSQMPIVKPGAGHPDVMAAEVIGSVVERDLLDALFAQRASLDDPLEKHMSLPLPQVGSGEPVADLMAVLGDADAAIVLVDGKPTGVVSRQDLLAFLAADTSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJM8</accession>
    <name>A0A2G1XJM8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_13830</name>
        <name evidence="12" type="ORF">CYQ11_01525</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51410">
        <property type="protein sequence ID" value="PHQ51410"/>
        <property type="gene ID" value="BLA24_13830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11751">
        <property type="protein sequence ID" value="PPT11751"/>
        <property type="gene ID" value="CYQ11_01525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="36"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="371"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="404"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="624" mass="65676" checksum="00862986C4E91A17" modified="2018-01-31" version="1">MTGGQAPAPHPGARHSARGAVAVMYRLTAGHRPAIAVATVFSVGASALGLAQPLLAQKIVDASGHGRALWPLLALLAALFLAEAATSALGRFLLERMGERVVRGLRLSLVSRLLRLEMREMGRHRSADLISRVTADTTLLREAVAQSLVDLVTGAAVATGAVVMMVLIDPLLLGLVILTVAVAAAIVASLLTGIRTAAERMQAAVGEIAADLERALGALPMVRTHCAEEREERCIGSRVEGSYEAGVRTAKLASVMSPVVEVAVQGSFLLVLVIGGMRVGRSDSLGDVVAFLLYASYLVVPLSSVFRTIGQIQRGMGAYQRVDEVLHLPVEPAGPGFAQEAPGETGECRKPASPSPSPAVPEPGEEPAPVLALSDVWFGYGPDRPVLRGVSLTVPHHRMVALVGRSGAGKSTVFSLVSRFYEPDGGAVLFDGRKASSMGRRECRSRVAVVDQSTHVVHGSLWDNITYGAPDASLPEVEEAVDRANLRPVVDRLPGGLACVLGERGGALSAGERQRVALARALLGEPSLLLLDEPTSHLDALNEAALSQVMQDITKRCAVLVIAHRLSTVQNADHIYVLDAGRVIASGRHDELLVRSDTYRELARAQSLRVSGAEGDAAAPSPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJQ1</accession>
    <name>A0A2G1XJQ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_14010</name>
        <name evidence="14" type="ORF">CYQ11_01705</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51456">
        <property type="protein sequence ID" value="PHQ51456"/>
        <property type="gene ID" value="BLA24_14010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16286">
        <property type="protein sequence ID" value="PPT16286"/>
        <property type="gene ID" value="CYQ11_01705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT16286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="294" mass="30911" checksum="137F738EEFC65343" modified="2018-01-31" version="1">MMLSFARRRYLVTGVLNQDSIAWHTARALQEAGAEILLTGFGRSRRITEAAAAGLPDPPDVLELDVTRPGDFPLLARELDKRWGGVDGVLHAVASAPKDAVSGNFLTTGPDSATHAFRTAAYSLHALTTTLAPLLGGPGRGGSVVGLDFDSSAAWPGYDWMGVGKAALGAVCRYLALYLGPSGIRVNLVAAGPVETVAGRGISTFDRIADRWEEQAPLGWDRADVARLTGPVLFLLSDLAATVTGEIVHADGGMHAVHMEGGGQVLHEAGRRAAQAGRPPREGGRRPPAKETTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJR9</accession>
    <name>A0A2G1XJR9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_13395</name>
        <name evidence="5" type="ORF">CYQ11_01115</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51498">
        <property type="protein sequence ID" value="PHQ51498"/>
        <property type="gene ID" value="BLA24_13395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11680">
        <property type="protein sequence ID" value="PPT11680"/>
        <property type="gene ID" value="CYQ11_01115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758359" description="Beta-lactamase domain-containing protein" evidence="2">
        <location>
            <begin position="38"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="424" mass="45413" checksum="8751A05BBC2A0284" modified="2018-01-31" version="1">MSRRRNLRDTSGVRWMGPVAVAAVMTLVAGAATAASAEPAPAVPDASGVRAALQRTMEAGAPGAFAVIRNHDGRGGDQTVALGAADLDGRPMDAGLRFRVGSNSKAFASVLVMRLAEQGRIDLDEPLRDFLPEGTLPLDWQMTGRQVMQHRAGVYDHTDDLLEHTGEETTAAFEQRIRDNVYEPADLVAMSVKHGPQSTPGARYAYSNTDYVLMGLAVEHLTGRPYADVLREWIIEPLRLRQTSFVVPRKAIDGPHATGYLTNDDRSKPLLDSTEQTASWIWSAGAVISTAEDLDRFLTALLAGSAGGLVSDGSLRQMPRVLPTPTAKISYGLGVREISLSCGKVLGHGGIVQGYQTQSFSTPHGERTVVVFANASNNGAVTQGLMGALEPAFCGKHTRGPGRPFTEDTDRNDTTVPVVEDTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJW5</accession>
    <name>A0A2G1XJW5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_13945</name>
        <name evidence="7" type="ORF">CYQ11_01640</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51429">
        <property type="protein sequence ID" value="PHQ51429"/>
        <property type="gene ID" value="BLA24_13945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11770">
        <property type="protein sequence ID" value="PPT11770"/>
        <property type="gene ID" value="CYQ11_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304963" evidence="5">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="395" mass="42048" checksum="1AAE1766B351723B" modified="2018-01-31" version="1">MVLLPATTALTAAAAPGPAASVSASSGHGRADRSAPSPRLPEPTGAHAVGRSTLHLVDRDRPDPWVPEAGPRELMVDVYYPARAHTGRQAPYATTEEIRLFLKDRGLTGAVDPGVLSSTRTNSRTDARPEGGRHPLVVLSPGFSVSRYTQTVLAEELASRGYVVATVDHAYESAGTAFPGGRVLTCVACEKAQTPADFRAAARGRAEDISFVVDRLTGPRPAWRYAGLIDDRRIGVAGHSMGGASAASAMARDDRLKAGLNMDGGFRDPVPAGGLDGRPFLLLGTDDATHRPHGTDTTWDEAWQRLDGWKRWLTVSGSVHFSFCDMAWLTGQLGLPLADPPPPLSGSRATDIVRAYAGAFFDQHLRGVPQPLLDGPDPAHPEVRFQDPAAERPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKH5</accession>
    <name>A0A2G1XKH5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11695</name>
        <name evidence="4" type="ORF">CYQ11_02935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51743">
        <property type="protein sequence ID" value="PHQ51743"/>
        <property type="gene ID" value="BLA24_11695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11991">
        <property type="protein sequence ID" value="PPT11991"/>
        <property type="gene ID" value="CYQ11_02935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="320" mass="36280" checksum="0DD72C775CD2062F" modified="2018-01-31" version="1">MTTARTTRGRSPVLNLPRTATGFDQVLHALRGRKPRRATGLPGEPRWRREFVRRDAAGPRTSLEEFGYGSHELNHAHGTVDDTALVGPLRILTPEGLDCLAEVCDRLEPSAGSSRFIATRRLRSADLMSAFINNMIRDRDFLLACSRLAGVPLIPHPLRIPTAQINYFEGRGRPEIVRWHRDGMDYVLTIQLNGYEDYDGGRFLYFQGRTDEFPGVREDDPRIREAPCGERGTALFLHGSRIFHAVTPVTRGRRVTLVISFFCPYFARQDSNTFWHLAADDGIPATIPSWLRLKWPVRDPAMDFSLRAGSPVITWEDVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKM5</accession>
    <name>A0A2G1XKM5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11975</name>
        <name evidence="4" type="ORF">CYQ11_03215</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51793">
        <property type="protein sequence ID" value="PHQ51793"/>
        <property type="gene ID" value="BLA24_11975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12039">
        <property type="protein sequence ID" value="PPT12039"/>
        <property type="gene ID" value="CYQ11_03215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="45105" checksum="AFBABED06766C71B" modified="2018-01-31" version="1">MTTSERAPDRYPVRFWDVGDLKGLDFDPFMADRLRDDPVSRVKLPHGEGHAWLVTRYEDVKFVTSDPRFSRQAVLGRPITRLAPHFIPLDEAVGFADPPEHTRLRKSVAKAFTARSLDRLRPGAQRAADELLDAMERQGPPADLMEHLNGPLPLAVISDLMGVPEEDRPRMAEWTNVQLSAGHGRKASEQAKENMAAYFTELLGHRCAEPRDDLAGDLAQATTQGELSMAEAVAVALLIQASAAHAVRNNSGNMVYALLTHPQHTARLRSEPGLLPQAIEELLRFIPHRNAVGLARVATEDVEVGGVLIRAGEVVHSSYLTANRDPAVFDRPDELDFDREHNPHLSFGHGPHFCLGSMLARLESEIILATLLRRFPRLRLAEPVESVPWQRDALIRGPERLPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKN8</accession>
    <name>A0A2G1XKN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyoverdin chromophore biosynthetic protein pvcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11675</name>
        <name evidence="5" type="ORF">CYQ11_02915</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51741">
        <property type="protein sequence ID" value="PHQ51741"/>
        <property type="gene ID" value="BLA24_11675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11989">
        <property type="protein sequence ID" value="PPT11989"/>
        <property type="gene ID" value="CYQ11_02915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024677">
        <property type="entry name" value="HpaB/PvcC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500125">
        <property type="entry name" value="4_HPA_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="2">
        <location>
            <begin position="284"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000331-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="502" mass="55265" checksum="B0785D5AE4F413F4" modified="2018-01-31" version="1">MSGRTGSPSLMTGEEYLESLRDGRAVYVDGERVKDVTEHPAFANSALSVARLYDALHAPETRDVLTGTDDFGLRTHHFFKPARSSGDLLAAREAVAAWSRMGYGFLGRTPDYKAAFMSGLAANAGFYGEFAPNAVRWYKEFAGRGLYLNHVIINPPTDRKQAVHDMRDVFVHVEKETDAGIVVSGAKMLATGSAITNASFVAPVASAALTPGRGEDFAVVFFARMDNPGVKLICRTPYARPDRAPFDAPLSGRFDENDAVLVLDRALIPWEDVLVHRDVERSTGFYARSGFANLYNFQSGVRLSVKLELMAGLLSLGTRANGTDAFRGVQAAVGELVTLRDMVWGLTTAMATDPEPGTDGIVLPKLEYASAMRMYNAQVWNRVHEIFETTLGGAPLVVPSSARDLDHPELRPLIDRFYRGSDVTALDRIKLFKLIWDAIGTEFGGRHELYERNYSGNGEQVRLDALKWATRRGAVSSYEAFAHECMADYDTTGWVRGPWRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKQ6</accession>
    <name>A0A2G1XKQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12040</name>
        <name evidence="4" type="ORF">CYQ11_03280</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51806">
        <property type="protein sequence ID" value="PHQ51806"/>
        <property type="gene ID" value="BLA24_12040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12052">
        <property type="protein sequence ID" value="PPT12052"/>
        <property type="gene ID" value="CYQ11_03280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758366" evidence="2">
        <location>
            <begin position="40"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="15918" checksum="20D4F4DDBB96B569" modified="2018-01-31" version="1">MKSDQQHEGRHRGRLARRVSALIALALCAALLATPVAAAAPAATGAHPVVAEARSTVTTDDGAASAVTAAHRSPGAAAAHHAGSDHQVLAKDHKTLAKDKDKKKKKKKKGFFKRLGTTLLVIVILGILLVVVFVVLAIFLLRRAFKRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKT2</accession>
    <name>A0A2G1XKT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51749">
        <property type="protein sequence ID" value="PHQ51749"/>
        <property type="gene ID" value="BLA24_11725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="235" mass="24834" checksum="692A453AD8C7E0DA" modified="2018-01-31" version="1">MSPQGQGGALTWGPISLSDAGTGLERRTIVFPWNSPGLGAANTGDVDRAVAAFQAYVRLALCCSPGQRAPACERAHYLRERLTSGRAPDLEPAGRRLVERLGALLDTLSPAPPPGCVLRLLLHRYVREARRVEHGPAARDLAAPLARLARAEFTVVRVVLAGAGAWEELGGLSAALRTRPFWDVRRLAAATLLRLAPDGYSLNALAPAGAGAPDDRIRAMVEASSRELALLGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU2</accession>
    <name>A0A2G1XKU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11855</name>
        <name evidence="4" type="ORF">CYQ11_03095</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51858">
        <property type="protein sequence ID" value="PHQ51858"/>
        <property type="gene ID" value="BLA24_11855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16322">
        <property type="protein sequence ID" value="PPT16322"/>
        <property type="gene ID" value="CYQ11_03095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="184"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="390" mass="42528" checksum="1B93726270554B5F" modified="2018-01-31" version="1">MGAAAAPRRRLRRPGLRPRHAAARPAADARHPPRRPAGQARGALRRRLRPGPAARRLRPPAAPALLRPAAVDGAPADRDRPRRRAGAHRALPPLHRRGLLAGRVAEVREHPAHPPGVDGDLRLHRLVPVAGPHRPRAAHHQGACVTALDYNQLAAEYARHRRPYPGLVEFLAEFAGVTGDSAVLEMGCGTANHLASLQRLTGACALGVDPFPEMLKAAGTHEAELELRTGRAEEIAALDLPEASFDLIFSVDMIHYVREPGRYFEGAFRALKPGGVLCTATDSEEIIRTRVPVAQYFPSTVEVELGRHHAIDDLLAELRFAGFTDGQQRVFESTYELTDATKYREKAFSSLHLIPDEEFETGVAALTAELAKGPLKANNRTCAVLARRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL39</accession>
    <name>A0A2G1XL39_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_03390</name>
        <name evidence="10" type="ORF">BLA24_11180</name>
        <name evidence="12" type="ORF">CYQ11_16895</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51891">
        <property type="protein sequence ID" value="PHQ51891"/>
        <property type="gene ID" value="BLA24_11180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53127">
        <property type="protein sequence ID" value="PHQ53127"/>
        <property type="gene ID" value="BLA24_03390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14320">
        <property type="protein sequence ID" value="PPT14320"/>
        <property type="gene ID" value="CYQ11_16895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="221"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="431" mass="46620" checksum="062632C36D20792B" modified="2018-01-31" version="1">MVKLALRSGLRWKVSLAIAGVGALVAVALSLVVHNAARVSMLNSSRDQMDDRVQIAQRYYESTGGKLMLRAKVDDPNLPKPLREAADVGLRATYLQDDGNAAPEVWASTPLRNGKVLSIHSRFKDRYSILKDLDRALIIGSVSVVLGGCALGILVGGQLSRRLRKAATAARKLADGDPDVRVRDAIGGRVRDETDDLARAVDGMAEALRDRLEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVRDRAQAMRTLVEDVLEVARLDGFAERAEMQDIELGEFVRRRVRSVSPEAHVKTVRDAYVSTDPRRLERILGNLLANAAKHGKGPVEVTVEGRVLRVRDHGPGFPEELLREGPSRFRTGSEDRAGKGHGLGLTIAAGQARVLGARLTFRNADPEVEGGSGAIAVLWLPESSPTSTGSFPIISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLC8</accession>
    <name>A0A2G1XLC8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_10840</name>
        <name evidence="2" type="ORF">CYQ11_00710</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51939">
        <property type="protein sequence ID" value="PHQ51939"/>
        <property type="gene ID" value="BLA24_10840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11616">
        <property type="protein sequence ID" value="PPT11616"/>
        <property type="gene ID" value="CYQ11_00710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="19323" checksum="B167953A786E5948" modified="2018-01-31" version="1">MTRIDDTPPAWDERTQLTTFLDYARDTARAKCEGVSAENARKALLPGSPLMTMSGVINHLRWVEYYWFQVVFLGEEDQGPWTEEDPDREMRIAVDFPLAQLLDEYAEQSATYRELVAGNDLDQQAERAVRDGVRVDLRWILLHLTEETARHNGHLDILREMLDGTTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLQ9</accession>
    <name>A0A2G1XLQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08520</name>
        <name evidence="3" type="ORF">CYQ11_03775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52204">
        <property type="protein sequence ID" value="PHQ52204"/>
        <property type="gene ID" value="BLA24_08520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12137">
        <property type="protein sequence ID" value="PPT12137"/>
        <property type="gene ID" value="CYQ11_03775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="159" mass="17296" checksum="9D7A2B003DAF0D98" modified="2018-01-31" version="1">MPIPDYIRDLRAFAGHQLLWTPGVSAIVLDDEGRVLLGRRADTGQWSIIGGIPEPGEQPAAAIVREVHEETAVHCVPEKVLLVEALKPITYPNGDVCQFMDICFLCRAVGGEAKVNDDESLEVGWFDADALPPMEDFAVTRVKQAAAGGPTWFEGIGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLW8</accession>
    <name>A0A2G1XLW8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ORF">BLA24_08770</name>
        <name evidence="6" type="ORF">CYQ11_04030</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52245">
        <property type="protein sequence ID" value="PHQ52245"/>
        <property type="gene ID" value="BLA24_08770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12178">
        <property type="protein sequence ID" value="PPT12178"/>
        <property type="gene ID" value="CYQ11_04030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="52"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="347" mass="37561" checksum="8C26FEAE0847E7B1" modified="2018-01-31" version="1">MRTMWKGAIGFGLVSVPVRLYASIQEHGTRLHQVHDEDGGRIHLKRVCDVCAEEVDYEHVAKGFEDEEGHTAVLTKNDLAGLPLPSKKLIDVLAFVDSDRIDPLRLQSAYYLAPESAAANKPYVLLRETLKQTDRVAVTKIALRTRESLALLRVHEDLLTLHTMYWPDEIRSAAGLAPPDSVTVRPQELKMATSLMDTLSEDFDLDELEDEYESALGELISAHLDHRPVAKKETAPAPDNVIDLMAALQASIDTAGKKGEQEPKKTAAGTDSATEKKTAKSRTGTAGRKTAATSKTTAKTTAKTTAKAASKTASKSTAVTKKSATGSTRSKTAAKKTTAKKTSRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM47</accession>
    <name>A0A2G1XM47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000089">
        <property type="protein sequence ID" value="PHQ52307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52307">
        <property type="protein sequence ID" value="PHQ52307"/>
        <property type="gene ID" value="BLA24_08340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="SSF50923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="275" mass="29971" checksum="AB50749774810367" modified="2018-01-31" version="1">MPGPVADAKCLDAVIRTGEGEPRLWFYGTQCLWDGEGASPQDIGSAFPDLPEDFSSQLDAVTVLADPASDDAYELFFFKGETFYHRAYTSTDRAFVPQAESRGVRSLISEAFPGLSPQCQVSPDAVVVIGGVFFFMKGTRTEPALWRREDDPLHVLLVPLFEGDPAQAPPGDAFDVPPDVLDSVVGVVEASRLLGERLRGHTPLPPLRDRGDRTPWSSAAADQERTRRATNAPCAASSTHSRRTGRAGWPWAGASTRATSSPCWRRCRRSGARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM52</accession>
    <name>A0A2G1XM52_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="5" type="ORF">BLA24_07780</name>
        <name evidence="6" type="ORF">CYQ11_00210</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52344">
        <property type="protein sequence ID" value="PHQ52344"/>
        <property type="gene ID" value="BLA24_07780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11547">
        <property type="protein sequence ID" value="PPT11547"/>
        <property type="gene ID" value="CYQ11_00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="101" mass="11692" checksum="24F5AD0805999A92" modified="2018-01-31" version="1">MAKKSKITQNEKRKEIVERYAARRAELKEIIRRPSFSAAEREVAIAELRRQPRDASATRVRNRDSVDGRPRGYLRKFGLSRVRARQQAHSGFLPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMD2</accession>
    <name>A0A2G1XMD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07970</name>
        <name evidence="2" type="ORF">CYQ11_00405</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52376">
        <property type="protein sequence ID" value="PHQ52376"/>
        <property type="gene ID" value="BLA24_07970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11578">
        <property type="protein sequence ID" value="PPT11578"/>
        <property type="gene ID" value="CYQ11_00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7284" checksum="3B25E4834C6A6A78" modified="2018-01-31" version="1">MTSRFYGLATNPQQLVSGLQDHAIPAADAPTMIYLHATAVWLQGTRDWMVNSGQCQPAATRAAGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMP4</accession>
    <name>A0A2G1XMP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07055</name>
        <name evidence="2" type="ORF">CYQ11_27210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52525">
        <property type="protein sequence ID" value="PHQ52525"/>
        <property type="gene ID" value="BLA24_07055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16062">
        <property type="protein sequence ID" value="PPT16062"/>
        <property type="gene ID" value="CYQ11_27210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="26634" checksum="9C9BFBC6F871D087" modified="2018-01-31" version="1">MSVSTARPEPGIAVLTVDFPPVNALPVQGWFELAGAVRAAGSDPGTRCVVLTAAGRGFNAGVDIKELQRTPGNDALIGVSHGCFEAFSAVYECEVPLVAAVHGFCLGGGIGLVGNADAVVASDDATFGLPELDRGALGAATHLARLVPQHLMRTLYYTSRTVTARELHAHGSVWRVVPREDLTAAALELAREIAAKDASLLRLAKAALNGIDPVDVHRSYRYEQGFTFEASLGGAGDRHRDAFVAGHRGRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR0</accession>
    <name>A0A2G1XMR0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07160</name>
        <name evidence="3" type="ORF">CYQ11_27315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52544">
        <property type="protein sequence ID" value="PHQ52544"/>
        <property type="gene ID" value="BLA24_07160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16082">
        <property type="protein sequence ID" value="PPT16082"/>
        <property type="gene ID" value="CYQ11_27315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="106"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="470" mass="51518" checksum="45293B2D49E7712D" modified="2018-01-31" version="1">MTTPVESGTGTVDPPGRLSLGTEAARNLATTTKSVPQMQGITSRWLLRLLPWTQVSGGTYRVNRRLTHTLGDGRVEFFTTGAEVRVIPAELGELPLLRGFSGTEALQELADRFTQREFRPGEMLVEAGRPADQVVLLAHGKAEKVRTGEYGDPVVLGVLADGGYVGDRPLAAGAPGDWDFSVRALTACTVLTLPHQEFQEVLERSAELRSHVESYRDRATLPQNEHGESAIDVASGHVGEPALPGVFADYEPTPREYGLSVAQTVLRVHTRVADLYNEPMNQLEQQLRLTIEALRERQEHEMVNNRDFGLLHNADLSQRIHTRSGPPTPDDLDELLATVWKDPSFLLAHPRTIAAIAREFNRRGVYPDSVDVNGHAVPAWRGVPIFPCNKIPVSESGVSSVLLMRTGEENQGVIGLHRTGIPDEYQPSLSVRFMGISEQAIMSYLVSAYYSAAVLVPDALGILEHVEVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNA5</accession>
    <name>A0A2G1XNA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05380</name>
        <name evidence="2" type="ORF">CYQ11_01840</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52708">
        <property type="protein sequence ID" value="PHQ52708"/>
        <property type="gene ID" value="BLA24_05380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11802">
        <property type="protein sequence ID" value="PPT11802"/>
        <property type="gene ID" value="CYQ11_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="411" mass="43965" checksum="C07D4C2D5566FA6A" modified="2018-01-31" version="1">MTALPHITAAQRRARLVRRHLLAPSVREKAPEAAADALVGLHATDPATVFLAAAARMHAPTAGAVEAALYGTPAGRPAGGQPAGAPALARIRCMRRTMFVVPAPLAPAVHAATAGGHAHRHRTDAMARLHDALGWDARRYAAVEHATLQALTAHGAATAVQLAAAIPDLREQIITFPGKPYESRQRASTPVLGVLAAEGRIRRARPAGSWTSAQFRWAPARPLPEVPVAEAKTELARRYVAAFGPVTVDDVRWWTGWTLTDTRKALAATGAQAVELDEGTGYSLPEHLDVPDDAPEPSAALLPGLDPTPMGWRHRGWYLDGDHTKALFDRNGNIGPTIWWNGRIVGAWAQQPHGHINHHFLTDPGREGRAAVATEIERLTAFLGGVRVTPCYRTPLERRLSAPPSGARTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNA8</accession>
    <name>A0A2G1XNA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_06200</name>
        <name evidence="6" type="ORF">CYQ11_03725</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52693">
        <property type="protein sequence ID" value="PHQ52693"/>
        <property type="gene ID" value="BLA24_06200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12127">
        <property type="protein sequence ID" value="PPT12127"/>
        <property type="gene ID" value="CYQ11_03725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019295">
        <property type="term" value="P:coenzyme M biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022401">
        <property type="entry name" value="Cysteate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03844">
        <property type="entry name" value="cysteate_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0174">Coenzyme M biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="4">
        <location>
            <begin position="70"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="437" mass="47506" checksum="3CB94F69B6E60F5D" modified="2018-01-31" version="1">MKNPEERHYRIVCPLCGRRQEDDGLTLTCASDHEPALLHTEYREKEFRPRPEADGIFRYADWLPVVRSFPQAGRTVVFRSESLSAFLGMPGLRIAFNGYWPERGAFLETCTFKELEAYTVLGRLPEEPVALVVASAGNTAAAFASVCSRYAKPCLLIVPEGGLARLKLREPLHPAVRLVVMDGADYSDAIALSEAVAKLPGFLLEGGVRNVGRRDGLGTVMYAAMEEAGELPEYYFQAVGSAAGAIAVHEAAKRIQRAVPAEGDRPLPRLMLSQNASFAPLQQAWHSGRRALVPAERDRQAIESAYADELTNRFPPYAVHSGVHDVLTESRGDVLTVDKSSALAARQKVLDLESIDLEPAAAVATASLFAAVSEGRVPRDASVLLNLTGGGRGRLARDHVLHQAEPDLRIAAGASLDDALERIRELFASDLCRQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNB1</accession>
    <name>A0A2G1XNB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_06085</name>
        <name evidence="5" type="ORF">CYQ11_03610</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52671">
        <property type="protein sequence ID" value="PHQ52671"/>
        <property type="gene ID" value="BLA24_06085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12105">
        <property type="protein sequence ID" value="PPT12105"/>
        <property type="gene ID" value="CYQ11_03610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="256" mass="27904" checksum="6C93BAB5C9A38FFA" modified="2018-01-31" version="1">MNANQDTKVIRIHTPQDAKRTLICLGFCGGGTAAYHQWNESLPPRTALAAVCYPGREGRFLEDCATDWDELADDATATVLSAIDRPYVLFGHSMGGWMAFEVATRIERGGAQGPEALVVSSCNAPDRGLTERDMFPAQHQSDTELMTWMTSHGLMPEHVVGDPDLEGMALELMRADIKVRDSFHYTPGAKVRAALQMLSAADDPVIESDAGEQWRGVAQGDFRHDVLPGGHFYTPETWRRLPTHIAALNASAGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNV1</accession>
    <name>A0A2G1XNV1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HypC/HybG/HupF family hydrogenase formation chaperone</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Ni/Fe hydrogenase formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypC</name>
        <name evidence="2" type="ORF">BLA24_05065</name>
        <name evidence="3" type="ORF">CYQ11_28465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52924">
        <property type="protein sequence ID" value="PHQ52924"/>
        <property type="gene ID" value="BLA24_05065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11415">
        <property type="protein sequence ID" value="PPT11415"/>
        <property type="gene ID" value="CYQ11_28465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="102" mass="10845" checksum="02A8362C3C464AA2" modified="2018-01-31" version="1">MCLAVPGKVVGIEERDGTRMARVDFGGAVKDVCLAYLPDIEVGDYAIVHVGFALQRLDEAAALATLDLFARIGALEEEFGDAWSRAAAEAGVVPAEPLEDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNZ5</accession>
    <name>A0A2G1XNZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_05270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52957">
        <property type="protein sequence ID" value="PHQ52957"/>
        <property type="gene ID" value="BLA24_05270"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="275"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1359"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2441"/>
            <end position="2515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1650"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1394"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="2773" mass="291051" checksum="76323F4D670566CC" modified="2018-01-31" version="1">MCEGGAVAFGGAGCGGWSGGVGSCSVVGVGGESARSSWVGELLEAAGDVAVFNHYGPTEATVGVVAGRLDAATVAGGVVPIGAPLGNSCAYVLDEWLRPVPVGVVGELYVCGVQLARGYVGRARLTAERFVACPFVSGQRMYRTGDRARWTADGRLVFAGRADDQVKIRGFRVEPAEVQAVLSTAHPDAAQVAVTVHEDKAGDPQLVCYVVPAEGADPTGVTDALRALATRTLPQHMVPAAFVVLDVLPLTGNGKLDRGALPAPDFAGVAGGGRAPADAQEELLCQAFADILGLPAVGVEDDFFALGGHSLLAVSLVERLRARGVAVSVRALFATPTPAGLAAVAGPRPVEVPPNLIPPGAEEITPGMLPLVDLTEAELACVVATVPGGAANIADVYPLAPLQEGVFFHHLMADQDAGDVYVLPMVLGFEARERLDAFLNAMQRVVDRHDIYRTAVVWDGLREPVQVVLRHADLPVEEVVLAPDGPQPADQLLAAGGAWIELDRAPLLRVSVAAEPGTGRWLALLRIHQLIRDHTTQEVLLGELWALLSGNEDSLPQPLPFREFVAQARLGVSRDEHERYFADLLGDVTETTAPYGLLDVHGDGASVQRAQLWTDDALAARVREVARSSAVSPATVFHLAWARVLGVLAGRDDVVFGTVLFGRMNAGAGADRVLGPFINTLPVRVRLDGRGVGEALSAMRGQLADLLAHEHAPLALAQRAGAVPAGSPLFTSLFNYRHSGLVPQEPGTEPEPPAGADDAFAGISQLMSRERTNYPVAVSVDDLGEGFRLTVDAVAPADAAQVCALLHTGLDHLVTALEQAPDERLDAVDVLDDAERHRVVAEWNRTDREVAAKTFPALFAAQVARSPRSTALVRGAHELSYAQLDERANRLARLLIGQGIGPESVVAVMLPRSVELAVAFLAVLKAGAAYLPVDPALPAERVSYLFADARPVHVLTDSACAPQVPAGPPVTVLGTPRTDARLDGFAPSDPTDAERVTALLPAHPAYVIYTSGSTGRPKGVVVSHGGVPGLAVAQGDAFGVGVGCRVVLLASPGFDASVMELVMALGSGAVLVVPEGGGGLAGEELAGVLVGEGVTHGLIPPSVLATVPVPVGDVLETLVVGAEVCSAGLASRWSVGRRLVNAYGPTEVTVLCTLSDAVVGGEVPPIGRPIVNTRVYVLDDTLRPVPPGVPGELYVTGAGLARGYVGQPGLTSERFVACPFEPGGRMYRTGDRARWRADGQLDFAGRADDQVKIRGFRIEPGEVEAVLAAHPGVAQAAVLVREDVPGDKRLVAYLVPSRQDPDDLVDTVRAHTADRLPSYMVPAAFVVLEALPLTVNGKVDRRALPAPDFAEVAGAGGRVPADAREELLCLAFAEVLGLPVVGADDDFFALGGHSLLATRLVSRVRAVLGVEVSLRTLFDNPTPARLAARVIHAAPGRVALGAGVRPERVPLSFAQRRLWFLGQLEGPSTTYNIPLVLRLSGELDRDALAVALRDVVARHEVLRTVFPMADGEPYQKVLTPEEAAFALKVVDVAEAELADAVDRASRHTFDLSGEIPVRARLFAVAPDEHVLVLVLHHIAGDGWSVGPLARDVAEAYAARCTGDEPQWPPLPVQYADYALWQRELLGDESDPDSVLSRQVAHWRDALSGAPQELDLPADRPRPAEASHRGHATGFAVPAATHRKLQALTREQGVTLFMVVQAALATLLSKTGAGDDVPIGVAVAGRTDQALDDLVGFFVNTLVVRTDLSGDPTFAELLGRIRETSLAAYENQDVPFDKLVEELAPARSLTRSPLFQVMLAVQNTGSPGGGPGAGLPGLRTEVLPGGTGGAKFDLDVSLGETFDSDGAPAGLRGVLRAAADLFDPDTADRLAGWLVRALEAMAADPLARIGDVDVLAPAERRRVLTEWNDTARTCPASTVPELFAAQAARTPDAVAVVCGETEVTYAELDARTNRLARCLTGRGVGPESVVAVSLDRSADLVATLLGVLKAGGAYLPLDTEYPAERVRFMLRDAGAMCLLADASARERLAAVADEEGLPVLVLDDPATAGELAALDEGALTPAERAGVLLPDHPAYVVYTSGSTGTPKGVVVPHAGVDRLVRDSGYIDLTPDDVIGQLASVSFDAATFEIWGALLNGARLAVSASTRLSVPETRDFLAGHRVSVLFLTTGLFNVLADADAEALAHLRVLLTGGEAYHPALFEKVLDRLPGVRLSHVYGPTENTTFTTEHRVRHADLKGGATVPIGGPISDTRLYVLDERLNPVPPGGTGELYVAGLGLARGYAGRAALTGERFVACPFEAGERMYRTGDRARWTAGGGVVFAGRADEQVKIRGFRIEPGEVEAVLSGHPAVARATVVVRQDVPGDKRLVAYLVPAEEAGRDPAALAGAVGAYAAERLPRYMLPAAIVPLDALPLTVNGKIDRAALPEPGPAARATGGGATDRGSVGALEQAMCEAFAEVLGLDAVGLEDDFFALGGHSLLAVSLVEKLRERGVDVAVRAVMAHPTVAGLRNTLSLSSVRDSLGPLLPIRTTGDQPPLFCVHPGGGLSWCYTPLARHLPADRPVYGLQARGLDGTGALPADVVEMAADYVERIREVQPAGPYHLLGYSFGGSAAHEIAVRLQDLGEEVASLIIMDSFPTAPTDLSGPSGPAEPAGEDDAEVAEWAELIRAELGHALGGLSDEEIVVLARVFRNNGDIRSAHHFGRFDGDALLLVAAEGRPDGESGAARWAPHVSGRVQETRLPCSHADMVRPDMLGLVGEAVAAWLRGTRSGDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP17</accession>
    <name>A0A2G1XP17_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52960">
        <property type="protein sequence ID" value="PHQ52960"/>
        <property type="gene ID" value="BLA24_04440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="125" mass="13113" checksum="F9EA44DEA3161707" modified="2018-01-31" version="1" fragment="single">MTAAIVGIGAELPPRTVPNSDFTHLDTSDEWITKRTGIRERRFLAPDGHLADLALAACRQALSAAGCAARDVRHIVVATTTPDRVTPGLAVEVATRLGMPQAAAFDLHAACAGFVYALDHAAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP54</accession>
    <name>A0A2G1XP54_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05165</name>
        <name evidence="2" type="ORF">CYQ11_28365</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52939">
        <property type="protein sequence ID" value="PHQ52939"/>
        <property type="gene ID" value="BLA24_05165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11399">
        <property type="protein sequence ID" value="PPT11399"/>
        <property type="gene ID" value="CYQ11_28365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="12988" checksum="4DE83182D9887456" modified="2018-01-31" version="1">MSGPDTADHVSVHLTSCGHDDATAVFEALESAFPSGSKVRAVDTGAGAPTVWSTVVDARTRVAPGTTVPSPLGGAVTVDLFGAADPVRQVREELAAAFGVEDHGTVPGEHELETRLVLTAHPDHAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP57</accession>
    <name>A0A2G1XP57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04135</name>
        <name evidence="3" type="ORF">CYQ11_14125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53014">
        <property type="protein sequence ID" value="PHQ53014"/>
        <property type="gene ID" value="BLA24_04135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13878">
        <property type="protein sequence ID" value="PPT13878"/>
        <property type="gene ID" value="CYQ11_14125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="9022" checksum="9663DD65A6010644" modified="2018-01-31" version="1">MRVMCGRFRCVMAAGERPLNEVVFLTVAEVAAVMRVSKMTVYRLVHSGHLPAIRVGRSFRVPEQAVHEYLRESYVGVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPH6</accession>
    <name>A0A2G1XPH6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02020</name>
        <name evidence="6" type="ORF">CYQ11_04380</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53145">
        <property type="protein sequence ID" value="PHQ53145"/>
        <property type="gene ID" value="BLA24_02020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12235">
        <property type="protein sequence ID" value="PPT12235"/>
        <property type="gene ID" value="CYQ11_04380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="214" mass="23410" checksum="EAA255A689AB4936" modified="2018-01-31" version="1">MARSTAQRVAAALRDRIEGGDLPPGTQLSEEALGRELGVSRNTLREAFRLLVHEGLVVHLLNRGVFVRVLEPADVTDIYRVRAALETAGVRAAATAPAPLRDAVTAAVEEAEQAAGADDWQRVGTADLRFHRALAALAGSARIDAAMERLMAELRLAFHEMPSPRHFHEPFVGRNRALAGLLAKGEHARAEAELTAYLDDARRLILDTMREEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQC9</accession>
    <name>A0A2G1XQC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00475</name>
        <name evidence="3" type="ORF">CYQ11_07485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53444">
        <property type="protein sequence ID" value="PHQ53444"/>
        <property type="gene ID" value="BLA24_00475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12749">
        <property type="protein sequence ID" value="PPT12749"/>
        <property type="gene ID" value="CYQ11_07485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="769" mass="82247" checksum="3AA77D7F91AE7413" modified="2018-01-31" version="1">MTSRTDKSGTSTYGYDAAGRLNRTEDAVTGGQTTTAYDAAGRVLQEQYATKPAGSTDWQLGAKRGYGYDQLGRLTESKVTSADGTAQVMSNTYDYDLNNRLTKKTTSGISGAGTEAYAYDKSGRMTSWTSDGKTTTYAWDDAGNRVKAGDVPATFDEANRLLTDGAGRYGYTPRGTLSSVDTGSGKRSLTHDAFERRIADGDTRFTYDSLDRVSRNGDTAFTYDGGSNNLVSDGSSTYSRSPGGALLGSTDGTTRQRAVTDQHTDVVAGLSPDGTKVVGSTAYDPFGSVRAKSGSRSSLGFQSGWTDPSSGDVNMAARWYQPGTGRFASRDTWQLDASPSVQANRFVYGNASPLNGTDPSGHCFWDACAAELIAGAAAYGAYTTCVQYCGGLTSSLSDAVDWTRDRWNDWASDDTDSGTNEWTFELGGRIVGSIVRDYSIVRGIWRSVRSIPRSWDVDEDEGGWGGGGYDGGCIRCDGGSGGPVGTPLRNPRGTRKRHVQPPRPPRPKIDQNPNNGKNPKPAPKRPAPKPDWDPGGGWKPGDVVNTVITAANILDLFNGDSYDPDREPGAAPRSAPGADPSRGGRLNGDQDDDDVDCTKLLEMDTVSKGMSGPVCFRAPSGATAAQIEELKDHIAAINAIPGYWSPKGRVSPPKEFVGNKTLSAVATEYLVNHKKELKGTPYEYRTGQAAGHLPDTTWSGKEKPYCWHQQDGRVNSTVGSYANKYPVGYKPTGFYYAGVRNDPSTYTTEYESGSVSVGSYGLCSISRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQG8</accession>
    <name>A0A2G1XQG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00460</name>
        <name evidence="2" type="ORF">CYQ11_07470</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53441">
        <property type="protein sequence ID" value="PHQ53441"/>
        <property type="gene ID" value="BLA24_00460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12746">
        <property type="protein sequence ID" value="PPT12746"/>
        <property type="gene ID" value="CYQ11_07470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="65" mass="7553" checksum="0CE1F08E55E197CA" modified="2018-01-31" version="1">MTDHIARWFRRVRALLAPVPTPPPPRRKPPHCPRATEHPYTYTVVVSAHGINFIPRQPHRAQVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQS2</accession>
    <name>A0A2G1XQS2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">atpF</name>
        <name evidence="16" type="ORF">BLA24_00335</name>
        <name evidence="17" type="ORF">CYQ11_07345</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53560">
        <property type="protein sequence ID" value="PHQ53560"/>
        <property type="gene ID" value="BLA24_00335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12724">
        <property type="protein sequence ID" value="PPT12724"/>
        <property type="gene ID" value="CYQ11_07345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ53560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="20326" checksum="56FF3C0E3CC6757F" modified="2018-01-31" version="1">MAMTFALDVGPLKPEPAPLILGLVLFFLTFWVMAKVILPRVNKVLIERENATEGRFEEAEETRAEAARVHAEYQELLAEARHEAARLRQESFEQGTAIIAELRAEGQRQREEIISAGHAVIDAERAVAEAELREQVGVLATDLAGKIVGEPMTDYARESGVVDRFLEELRTAKASDAAAGETRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9E7</accession>
    <name>A0A2G1X9E7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_30540</name>
        <name evidence="7" type="ORF">CYQ11_23635</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47852">
        <property type="protein sequence ID" value="PHQ47852"/>
        <property type="gene ID" value="BLA24_30540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15477">
        <property type="protein sequence ID" value="PPT15477"/>
        <property type="gene ID" value="CYQ11_23635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="95"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="294" mass="31297" checksum="897FF00A7563F85B" modified="2018-01-31" version="1">MPPVSLESAESVGAPTALSTVKGLTEARAKAARNRRLLVLGARVLLLAALLTTWEVLARTKTIDPFNFSMPSKIWDQIVQWTTHGTTHGSLGRQIWVTLYEALVGWGVGVTAGVVLGITLGRVRFLADVLGPFIKVLNALPRIVLAPIFIIWFGLGPESKIASAVVLVFFPVFFNAFQGAREVDRNLVANARILGAGDRRVTLQVVVPAATSWIFTSLHVSFGFALIGAIVGEFIGASEGIGLLVAESQGTFNAAGVYAAMAILAAVALLAEGLLTFAEKRLFRWKPGSPGGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA09</accession>
    <name>A0A2G1XA09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31970</name>
        <name evidence="4" type="ORF">CYQ11_25025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48066">
        <property type="protein sequence ID" value="PHQ48066"/>
        <property type="gene ID" value="BLA24_31970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15692">
        <property type="protein sequence ID" value="PPT15692"/>
        <property type="gene ID" value="CYQ11_25025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="456" mass="48009" checksum="3D621F8A799E5DDE" modified="2018-01-31" version="1">MSAGEGFEGVLIRHGDRDYDRARADAVWNGRKPQRFPDAVVRAASEEDVPRALSYARSHGLRVSVRSGGHNWSGSPLRDGGLLLDLSGLARCEVDPVPATATVGPAATGQDLVAALAPHGLAFPVGHCPTVAVGGFLLSGGLGWNSRAWGAACADVQEIQAVTADGRTVICSETENSDLFWAARGAGPGFFAVTTRFRLGLHPQPAAIVTTSLTFPVSEVGRVAAWGERTARELPPYVETALVLRASGDPAATPPAGPQIMIGATSFAASREEALASLAPVDACPFAASAESRQAPEPTSFAALHAGAGSLWPPGRRYAADTLWSAETYETQLTRAADAVAHAPSPRSLVLAPVQPVSEEPALLRNMAFSPLGRSYCVSYAIWDDPGADGANDRWLRGVAAATDPSGHGGRYVAEADLEADAARARRAYAPADWDRLQELKARWDPENVFHPYLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA16</accession>
    <name>A0A2G1XA16_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Purine permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_32105</name>
        <name evidence="10" type="ORF">CYQ11_25165</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48087">
        <property type="protein sequence ID" value="PHQ48087"/>
        <property type="gene ID" value="BLA24_32105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15713">
        <property type="protein sequence ID" value="PPT15713"/>
        <property type="gene ID" value="CYQ11_25165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="461" mass="46927" checksum="2DA01C413D14CFE9" modified="2018-01-31" version="1">MTAEPGATERPQERPAPPPGEVHPVDRLPGPGRLLASGFQHVAASYAGVVAPPLVVGAFVGLPPAQTTFLVGAALFTAGLATLLQTIGFWKVGARLPFVNGVSFAGVAPMLAIADARPGHAGALPAIQGAVIVAGVLGFLLAPCFCRLVRFFPPVVSGTVITLIGITLLPVSFGWIQGGHPERPASLTNLGLAGATLVTVLVLRRLLTGFGRQIAILLGLVAGTLLAIPTGAVDTAATRAAAVAGFPEPFHFGHPLFEGPAIVSMCVLMLVCMTESTADMLALGEIVERPADERTIAAGLRADTLGSAVSPLFNGFANSAFAQNVGLVALTGVRSRFTVAACGAMFLLLGLSPVCASLIALVPQPVLGGAGIVLFGTVAASGVNVLRGAGLDRGDNLLIAATSLGVGMIPVVSRTFYANAAVPETLRIILDSGVSAGCLTAVLLNLAFNHLGRRRRPVRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA59</accession>
    <name>A0A2G1XA59_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pucD</name>
        <name evidence="3" type="ORF">BLA24_31865</name>
        <name evidence="4" type="ORF">CYQ11_24920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48049">
        <property type="protein sequence ID" value="PHQ48049"/>
        <property type="gene ID" value="BLA24_31865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15675">
        <property type="protein sequence ID" value="PPT15675"/>
        <property type="gene ID" value="CYQ11_24920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017609">
        <property type="entry name" value="Xanthine_dehydrogenase_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03196">
        <property type="entry name" value="pucD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="35"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="794" mass="83687" checksum="7461BF293FDE47D3" modified="2018-01-31" version="1">MSDDTRTPAGVTRRGGTRGGVGESTLRPDGTLKVTGEFAYASDLWHEDMLWGFTLRSPHAHARIRSVDVSAALATAGVHAVMTHRDLPAETRYGLEIKDTPVLADGVVRHHGEPVALVAADHPETARRAAAKIVVDYEQLPVVTGEESATAPGAPVLHPGRTDDHARHVPHPNIVHRQPVVRGDVAAARARADVVVTGDYEVGMQDQAFLGPESGLAVPAEDGGVDLYIATQWLHADLRQIAPVLGLPEHKVRMTLSGVGGAFGGREDLSMQAHACLLALRTGKPVKIVYNRFESFFGHVHRHPATLRYEHGATRDGRLCHVKARIVLDGGAYASSSPAVVGNAASLAVGPYAVDDVDVEAIALYTNNPPCGAMRGFGAVQACFAYEAQMDKLADALGMDPVEFRRVNAMAQGAVMPTGQVVDSPAPVAELLRRVKAMPLPPRRQWETAGGSPDVRALPGGLSNTTHGESVVRGVGYAVGIKNVGFSEGFDDYSTARVRLEVTGGEPVATVHTAMAEVGQGGVTVHAQIARTELGVSRVTVAPADTAVGSAGSTSASRQTYVTGGAVKHACEAVREKVLELGRAKFGTYHPAWATAELLLEDGKVVTDGGETLASLADVLEGESCEAELEWRHRPTQPFDPRTGQGFGHVQYSFAAHRAVVEVDTELGLVKVVELACAQDVGKALNPLSVAGQIQGGTTQGLGLAVMEEIVVDPVTAKVRNPSFTDYLIPTILDTPAIPVDVLELADHHAPYGLRGVGEAPTLSSTPAVVAAIRRATGLALARVPVRPEHLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF8</accession>
    <name>A0A2G1XAF8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">BLA24_32810</name>
        <name evidence="5" type="ORF">CYQ11_25860</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48203">
        <property type="protein sequence ID" value="PHQ48203"/>
        <property type="gene ID" value="BLA24_32810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15829">
        <property type="protein sequence ID" value="PPT15829"/>
        <property type="gene ID" value="CYQ11_25860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="28997" checksum="2BD723C4D673AE88" modified="2018-01-31" version="1">MGRVTARRRVIRIRDGAVSARPDTLVAEEPLEIRLNGKPLAITMRTPGDDFDLAAGFLVSEGVLGGAEELANIVYCAGATDDGSNTYNVVDVRLAPSVPVPAVSLERNVYTTSSCGLCGKASLDAVRTTARWPLSDGPSPLRLETGLLAALPGRLREAQRVFDRTGGLHGAALFSAEGELLDVREDVGRHNAVDKLVGRALREGMLPLAGAVLLVSGRASFELAQKAVMAGIPVLAAVSAPSSLAVDLAVETGMTLIGFLRGSSMNVYAGEERVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAJ9</accession>
    <name>A0A2G1XAJ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent dioxygenase AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_33130</name>
        <name evidence="8" type="ORF">CYQ11_26180</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48256">
        <property type="protein sequence ID" value="PHQ48256"/>
        <property type="gene ID" value="BLA24_33130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15886">
        <property type="protein sequence ID" value="PPT15886"/>
        <property type="gene ID" value="CYQ11_26180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="PTHR16557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23323" checksum="A6D58551E699A7EE" modified="2018-01-31" version="1">MDGELFPRPSAEVAPGAVHVPGWLGPADQRRLLAACRRWAAPPAGLRTVRMPSGGEMSVRTVCLGWHWFPYGYARTVVDGDGAPVKPFPAWLGELARDAVARAYGREAGPEPYDIALVNFYDARGKAKMGLHRDGDEKSLAPVVSLSLGDTCVFRFGHPGGRTRPWTDVELRSGDLFVFGGPSRLAYHGVPRTLPGTAPPALGLDGRLNVTLRVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP5</accession>
    <name>A0A2G1XAP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_33285</name>
        <name evidence="2" type="ORF">CYQ11_26335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48281">
        <property type="protein sequence ID" value="PHQ48281"/>
        <property type="gene ID" value="BLA24_33285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15911">
        <property type="protein sequence ID" value="PPT15911"/>
        <property type="gene ID" value="CYQ11_26335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="131" mass="14062" checksum="3F7BDD2B77AAC66D" modified="2018-01-31" version="1">MPENDSPLRTEYDFQLPHGYVDAAGTVHRQGAMRLATARDELSPLIDQRVRENPAYLGVILLSLVITRLGTVSEVHAGVVEQLFAKDLAYLQDLYRRINGLDSSHGAVACPSCGTSFALPGPASGGRLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB44</accession>
    <name>A0A2G1XB44_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29300</name>
        <name evidence="4" type="ORF">CYQ11_06175</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48464">
        <property type="protein sequence ID" value="PHQ48464"/>
        <property type="gene ID" value="BLA24_29300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12539">
        <property type="protein sequence ID" value="PPT12539"/>
        <property type="gene ID" value="CYQ11_06175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304759" evidence="1">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="40"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="27144" checksum="0AF5FF1F84B2A390" modified="2018-01-31" version="1">MKLSRFAGSVSALALTVALAFGGAGAAHAAEHASTPAYVALGDSYASGVGAGNYDSASGACKRSTKAYPALWAAAHAPSRFTFVACSGARTGDVLSGQLASLNSSTGLVSISVGGNDAGFADTMSSCVLGTDSSCLDRIARARAFIQDELPAKLDSVYTAISSRAPAARVVVLGYPRFYKTGGVCIGLSDTKRKAINAAADQIDTVIAKRAADHGFAYGDVNSTFAGHELCSGSAWLNSVAFPVDESYHPNAAGHSRGYLPVFTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB69</accession>
    <name>A0A2G1XB69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29360</name>
        <name evidence="5" type="ORF">CYQ11_06115</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48473">
        <property type="protein sequence ID" value="PHQ48473"/>
        <property type="gene ID" value="BLA24_29360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12529">
        <property type="protein sequence ID" value="PPT12529"/>
        <property type="gene ID" value="CYQ11_06115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="362" mass="36459" checksum="5732D3B21585D71A" modified="2018-01-31" version="1">MVRAAVLPAVGAPLEIAEIDLPAPGPGQVRVRVAAAGVCHSDLSLCDGTLRQPVPAVLGHEGAGTVVAVGEGVRHVAPGDQVVLNWAPSCGACHFCGLAEPWLCARAAAAATVPYATLRADGRALHAGLGTAVFAEETVVGADAVLPLPEGVPLAEAALLGCAVLTGYGAVHHNARVRAGESVVVVGAGGVGLATLRAARLAGAGTIVAVDVSPDKEELARAAGATEFLLASDDTARRVRALTGGHGADVAVECVGRAGSIRTAWSSTRRGGRTTVVGIGGKDQQVSFSALELFHFGRTLSGCVYGNSDPAKDLPVIAGHVREGRFDLAGLVTDRIGLDGIPGAFEEMVAGRGGRALVVFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBC1</accession>
    <name>A0A2G1XBC1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29620</name>
        <name evidence="3" type="ORF">CYQ11_05855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48516">
        <property type="protein sequence ID" value="PHQ48516"/>
        <property type="gene ID" value="BLA24_29620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12485">
        <property type="protein sequence ID" value="PPT12485"/>
        <property type="gene ID" value="CYQ11_05855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="80"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="528" mass="56968" checksum="BCD60E9661D3B160" modified="2018-01-31" version="1">MRKRDQWLAAPLGAGLAAALLSGCGSEDGNAAGTGESVVMGMSDEVLSTDPASGYDPGSWLLFNNVFQSLLSFPKGSTVPQPEAAKSCKFKDDSSTVYQCTLQDGLKFSNGHDLTSEDVAYSFRRTLKIKDKNGPAATMLSSIKDIQTPDKSTVIFRLSRSDATFPQKIASGAGSIVDHTEYSMDKLRTDGKAVGSGVYKLDSYDKSKAVFKVNASYKGPATVQNKGMTLKFFHGEQDALKDAVVKGDIDLAYRGLAMKDIADLETSGGKDIKVVEGTSAEVQHLVFNTKDPVVGKVGVRKAIAYLIDRSSLVRDVYKRTAEPLYSVVPSGITSHRTPFFDVYGDRPQLDKATAALKSANISGKVKLTLWATPVRYGPGTVPEFQEIAKQLNASGLFEADVQSVPLDEYEKGIEAGKYGVYVKGWVPDYPDPDNFTSPFFGEDNVLGNNYQSKEIAGILPATAAQGSRAATVGDFVKLQNTVAQDVPLLPLWQGKQYAVSSDRISGLQWTLDSSTVFRFWEISKAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBC6</accession>
    <name>A0A2G1XBC6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29650</name>
        <name evidence="7" type="ORF">CYQ11_05825</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48522">
        <property type="protein sequence ID" value="PHQ48522"/>
        <property type="gene ID" value="BLA24_29650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12479">
        <property type="protein sequence ID" value="PPT12479"/>
        <property type="gene ID" value="CYQ11_05825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="10637" checksum="5C0B0649A1EAEAD7" modified="2018-01-31" version="1">MTVQDEGLGDLEVWIDQDLCTGDGICAQYAPEVFELDVDGLAYVKSADDELLQDKGATTPVPLPLLNDVRDSAKECPGDCIHVRRVSDKVEVFGPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBS0</accession>
    <name>A0A2G1XBS0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_28610</name>
        <name evidence="8" type="ORF">CYQ11_06855</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48672">
        <property type="protein sequence ID" value="PHQ48672"/>
        <property type="gene ID" value="BLA24_28610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12647">
        <property type="protein sequence ID" value="PPT12647"/>
        <property type="gene ID" value="CYQ11_06855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="417" mass="41390" checksum="18C177719AAF1686" modified="2018-01-31" version="1">MENITLLIGIVIVTALVFDFTNGFHDTANAMATTISTGALKPKAAVAMSAVLNLVGAFLSVEVAKTISGGIIDESAGIRPEVIFAGLVGAIVWNLVTWLVGLPSSSSHALFGGLIGATIVSVGFDAVNADKIVMKVLIPAVAAPLVAGLAATAATRLTYRLTKGRDEQETAKGYRAGQIASAALVSLAHGTNDAQKTMGVITLALVAGGVVAPHSDPPLWVIVSAGLAIALGTYLGGWRIIQTLGKGLTDIRPAQGFAAQTGAATVILASSHIGFALSTTQVCSGSIMGAGLGRKGGVVRWSTAGRMVAAWVLTLPAAGLVAGGAALLADQGDWGVAAVAVLGLAVSGAIWAASRRKPVSHDTVNDLNVPQGLPAEPAGVVTAALQAVAPPPAGPLSAVPAAPAAQTAAPAAATATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY0</accession>
    <name>A0A2G1XBY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000160">
        <property type="protein sequence ID" value="PHQ48743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48743">
        <property type="protein sequence ID" value="PHQ48743"/>
        <property type="gene ID" value="BLA24_28190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="690" mass="79777" checksum="A7133278F72675FF" modified="2018-01-31" version="1">MSTNSPDDRSGGEPRRGGPRGPRSGGGGFRRDDRAGGFRRDDRGPRRDDDRGGFRRDERRDDRGPRRDDDRGGFRRDDRRDDRGPRRDDDRGGYRGGRPGGGFGPRRDDDRGGFRRDERRDDRGPRRDDDRGGFRRDDRRDERPSFRRDERRDERPSFRRDERRDDRGGRPGGGFGPRRDDDRGGFRRDERRDDRGPRRDDDRGGFRRDDRRDERPSFRRDERRDDRGPRRDDDRGGFRRDDRRDERPSFRRDERRDDRGPRRDDDRGGFRRDDRRDERPSFRRDERRDERPSFRRDERRDDRGGRPGGGFGPRRDDDRGGFRRDERRDDRGPRRDDDRGGFRRDDRRDERPSFRRDERRDDRGPRRDDDRGPRRSYRDDRQGGGGGYRGGRDDRSGGYGRRDDRDRDREPVKRLPIPEEVTGDEIDKDVRQELMSLPKTLAEDVARNLVMVAKLLDEEPEQAYEYSRIALRLASRVAAVREAAGFAAYATGKYSEALAEFRAARRMTGSVELWPVMADCERGMGRPERALAMAGEPEVHKLDKAGQVEMRLVAAGARKDMGQAEAAVVTLQSPELASNSIQPWTARLRYAYADALLEVGRESEAREWFAKALEADQGGTTNASDRLAELDGVEFTDALEEETEDEAEIAEPKAEDAEVKDEPKGETESAASADADADAEPKAGEGDSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCC5</accession>
    <name>A0A2G1XCC5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27760</name>
        <name evidence="4" type="ORF">CYQ11_17880</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48860">
        <property type="protein sequence ID" value="PHQ48860"/>
        <property type="gene ID" value="BLA24_27760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14493">
        <property type="protein sequence ID" value="PPT14493"/>
        <property type="gene ID" value="CYQ11_17880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="311" mass="32407" checksum="07F9E30EED69EDB0" modified="2018-01-31" version="1">MGIESDQLVYDYLSQVGDLAQRQSLTSGDRMRLVSRLRAEIERRRADEGAETPAAVQRILDGLGTPSEAVAGAGSSSGGDDGPGTGRVPVQRREGESVRPPGGALPPHLATEEELRPRGGGDPDWWRMAPGPFDGGGAGDRVHGFVGGIEVPDMLRPPKEAGVAAAAPAAAGLRKAAKETEAALDEEEDEAAEDAEDAGRVPLSPVLVLVAVLLVVGAVLGNWFVLVAGWGLAYLTRRLTPAESKWAVMGVPGLAAAGGVAWLWGRVDERWGEPVPQGAMGTALAETLPVVVRVAAVASALFVMWRARKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCI0</accession>
    <name>A0A2G1XCI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27805</name>
        <name evidence="5" type="ORF">CYQ11_17835</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48869">
        <property type="protein sequence ID" value="PHQ48869"/>
        <property type="gene ID" value="BLA24_27805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14484">
        <property type="protein sequence ID" value="PPT14484"/>
        <property type="gene ID" value="CYQ11_17835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="182"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="545" mass="60563" checksum="BE390974AC67C6C1" modified="2018-01-31" version="1">MTDTTPATARAMPRARRPKGVAANAPGMRAAVYVRLSRETEESTSPERQRAACEALCQARGWQVIAVEEDIDVSGYSRGLDRPGLQRILARLAEFDVIVFFKIDRLARSTVDFAEIMKITQNEGVALASASEPLDLTSSMGRAMAKVIAVFAELESDTIGMRVSNAHEHLRREGRWTGGRVPYGYQVAPNPDGPGRVLVVNPEEAKTVREIVGRVLEKDSLMKIATDLTKAGVPSPGHSSRQTSGKRTDSKQWYTTTLKSLLTNPQLLGQVIEDGKPILRTDGLPLVTRPPILDMDTWHALQDELKRRTGAGERRRHNTALLRAVLYCGVCASRMYTYTSKGRLRYRCIGRLKQRQRTGEQGGCYGPSVPAEHTEEHVTGQFLEKFGSLQVVRMVEHVGEDFRPQIRQAEEALSDLEKDRYERGLFKGDDGAKRYADQYAKLEDRLASLKEKQRNAKPAGMEAVPTGRTFGELWKAADVEGKRDLLLEAGAYVEVAPAKRGAQRLDTSRLAVFFGEDGKIRRADADGKDVEEVIREAVARDLEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCJ1</accession>
    <name>A0A2G1XCJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose-6-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27935</name>
        <name evidence="4" type="ORF">CYQ11_17705</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48942">
        <property type="protein sequence ID" value="PHQ48942"/>
        <property type="gene ID" value="BLA24_27935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16629">
        <property type="protein sequence ID" value="PPT16629"/>
        <property type="gene ID" value="CYQ11_17705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000293">
        <property type="entry name" value="Channel_colicin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00276">
        <property type="entry name" value="CHANNEL_COLICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHANNEL_COLICIN" evidence="2">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="54349" checksum="1721410DCE88136C" modified="2018-01-31" version="1">MVDEHTHSAPIVVASNRGPVAYKLREDGSLAAGRGGGGLVSGLSAIGPDAGAVWVCAAMGEGDREAARRAGPRLPASDTAGHRVRMLDIAPDTFAAAYNGVANSVLWFLHHMLWQTPLEPVFDAEFRAQWAAYEAYNTAFADALAEEAAEGASVLVQDYHLTLVPGLLRERRPDLRIGHFSHTPWAPPDYYRLLPDDIAEQVLRGVLGGDRAAFLTRRWAEAFAGCCADVLGAEVVREDGAGGAAVAVRFEGRTTRLGVHGLGADGDFLRERAHREDVEQRMAVLRERVGPGRRAIVRVDRTELSKNIVRGLRAYRRLLEDRPQWRGKVVHIAFAYPSRQDLVVYRHYMAEVARVAREINAAFGTEDWEPVVLHLEDDFPRSLAAYRLADVALVNPIRDGMNLVAKEVPVVSDRGCALVLSREAGAAAELGDDAITVNPYDVEATARALHEALSMDPAERAERTKRLASAATALSPARWFVDQLAALERSGPGGDASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT0</accession>
    <name>A0A2G1XCT0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22965</name>
        <name evidence="4" type="ORF">CYQ11_23110</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48969">
        <property type="protein sequence ID" value="PHQ48969"/>
        <property type="gene ID" value="BLA24_22965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15386">
        <property type="protein sequence ID" value="PPT15386"/>
        <property type="gene ID" value="CYQ11_23110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="476" mass="51191" checksum="5846330619022E33" modified="2018-01-31" version="1">MSQSPHYGYPPQTPPPPVTSSFTASRLSSGGGSGRGPLRRKTVLGGLALVLLLAVGAWAAWAFTGDDSPGAKKPAQTAKGPAAGSVAWMAKPRTTPEKKFNSALGTWFTDHLVVKAEPDMVTAYDVKSGEKKWSFILTGPLCAASRESEGNVAVVATMFGGHCIDLKAFDLRDGHRTWDELVLADSGLGDTLSPEKWGKSEPRIALHEGHVYMTWNTGEQTRRLSDGKRVDEQKHDACEWVDAAGGAQLISITYCGEKEIQIRSLDPGKLGKPRWSTAMPRNDGFLSIVSTRPLVLSQSPGKNSADDQFDFVTLDPATGKEKARIAYNRNWRLGDCFLVTSGCTGALVDQDSLYVAGQGLTYAYDLTGGKERWTYKGDANRSTAPVAVHDGRLAVYTPATSDRPGRLAYVATSSGKALRTVDHSNDARDRKNEAVMGRIAGFPRLVDERLLLIKDGGLADENEGVILAISAPEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCW0</accession>
    <name>A0A2G1XCW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiD</name>
        <name evidence="7" type="ORF">BLA24_23465</name>
        <name evidence="8" type="ORF">CYQ11_22605</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49052">
        <property type="protein sequence ID" value="PHQ49052"/>
        <property type="gene ID" value="BLA24_23465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15302">
        <property type="protein sequence ID" value="PPT15302"/>
        <property type="gene ID" value="CYQ11_22605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="14"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="26910" checksum="40AD73B425DF17CD" modified="2018-01-31" version="1">MRTPPTVLTVAGSDSGGGAGVQADLKTMLALGAHGMSVVTAVTAQNSLGVQGVWPLPAQAVRAQFRSVVDDIGVQAVKTGMLASAELVETVAGLLAGVDAPVVVDPVGISKHGDALLAASALDAVRTKLLPAATVVTPNLDEVAWLTGVRVRSEADLRRAADAVLAYGPRWVLVKGGHLAGDAVDLLTDGVEEHRFRAPRHDNRHTHGTGCTLASAVAVGLAKGLPVPEAVSAAKAYVTGAIAAGFALGAGIGPVDHGWLAPRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD42</accession>
    <name>A0A2G1XD42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24120</name>
        <name evidence="3" type="ORF">CYQ11_21955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49156">
        <property type="protein sequence ID" value="PHQ49156"/>
        <property type="gene ID" value="BLA24_24120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15194">
        <property type="protein sequence ID" value="PPT15194"/>
        <property type="gene ID" value="CYQ11_21955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="169" mass="17926" checksum="551F45FC1E38B288" modified="2018-01-31" version="1">MDDTTAKRLVFAMLDADGDGVISREEYAARAERVALAAGRAEDDPLVVTARTAGRRAWELMDANGDGGVTFDEYAAWAGAEAFDTVCEPVLGALFDVIDTDGDGTLDLPEFTKLRAALGNPVGNIETAFDALDSDGDGRVRRADYIASIRAHITGEGSPMGKALYAEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD79</accession>
    <name>A0A2G1XD79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_23880</name>
        <name evidence="8" type="ORF">CYQ11_22190</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49119">
        <property type="protein sequence ID" value="PHQ49119"/>
        <property type="gene ID" value="BLA24_23880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15233">
        <property type="protein sequence ID" value="PPT15233"/>
        <property type="gene ID" value="CYQ11_22190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="120"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="332" mass="35255" checksum="0C7168B6FBACDBB0" modified="2018-01-31" version="1">MTAPLHDTGAAETAAVDVAAGVPAKAIEGRSPWRIAWVRLRRDKVALGGGVVVLLLVLVAVFAPVIVGLLGHPPNDYHEDQIDALFGTPKGSWGGINSDFLFGVEPVNGRDVFSRVVYGARVSLLVAFLSAVVAVVIGTAVGIVAGYFGGWIDAVVSRVMDLLLAFPQLLFILALISVVPNSLWGLSGSGVRMAVLIAVIGFFGWPYVGRIVRGQTLSLREREYVEAARSLGAGRFYILFRELLPNLVAPITVYATLMIPTNVLTEAALSFLGAGVKPPTSSWGQMLSKAVATYENDPLFMIIPGLAIFVTVLAFNLFGDGVRDALDPKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF9</accession>
    <name>A0A2G1XDF9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">BLA24_24765</name>
        <name evidence="10" type="ORF">CYQ11_21305</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49274">
        <property type="protein sequence ID" value="PHQ49274"/>
        <property type="gene ID" value="BLA24_24765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15075">
        <property type="protein sequence ID" value="PPT15075"/>
        <property type="gene ID" value="CYQ11_21305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="103" mass="10893" checksum="6C24E7F164AB243B" modified="2018-01-31" version="1">MVGSPTTAQESSQESAERWWAPVLRNALEPWHVLVIVLVVVVLFGSKKLPDTARALGKSLRILKSETRALKDDTATAGPPSGAQGDPAGTPTPAPRNAVDSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDG6</accession>
    <name>A0A2G1XDG6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">atpC</name>
        <name evidence="11" type="ORF">BLA24_24395</name>
        <name evidence="12" type="ORF">CYQ11_21675</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49209">
        <property type="protein sequence ID" value="PHQ49209"/>
        <property type="gene ID" value="BLA24_24395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15140">
        <property type="protein sequence ID" value="PPT15140"/>
        <property type="gene ID" value="CYQ11_21675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="124" mass="12949" checksum="83DC16BA60B16895" modified="2018-01-31" version="1">MAAELHVELVAADRSVWSGEATLVIARTTSGDIGVMPGHQPLLGVLESGPVTIKTADGNVVAAVHGGFISFADDKLSLLAEIAELADEIDVKRAERALERAKAEADAAAERRADVRLKAVTGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDQ1</accession>
    <name>A0A2G1XDQ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3311 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24895</name>
        <name evidence="3" type="ORF">CYQ11_21175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49299">
        <property type="protein sequence ID" value="PHQ49299"/>
        <property type="gene ID" value="BLA24_24895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15051">
        <property type="protein sequence ID" value="PPT15051"/>
        <property type="gene ID" value="CYQ11_21175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40034">
        <property type="entry name" value="PTHR40034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="89" mass="10003" checksum="8A5FA090BC583B27" modified="2018-01-31" version="1">MSEPPEQPPADGRKPVVPVPLFVAGVCLAIPFVAMLWVGSYARVTPSFIGIPFFYWYQMLWVVISTLLTVIAYVLVRRHERTRGRGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDT2</accession>
    <name>A0A2G1XDT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHP domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25290</name>
        <name evidence="3" type="ORF">CYQ11_20785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49365">
        <property type="protein sequence ID" value="PHQ49365"/>
        <property type="gene ID" value="BLA24_25290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14987">
        <property type="protein sequence ID" value="PPT14987"/>
        <property type="gene ID" value="CYQ11_20785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="293" mass="30577" checksum="D81CAA016836998A" modified="2018-01-31" version="1">MRIDLHTHSTASDGTDTPAELVRNAAAAGLDVVALTDHDGVGGHAEALAALPAGLTLVTGAELSCRLDGVSLHMLAYLFDPAEPEFARERDLVRDDRVPRARAMVAKLNDLGVPVRWERVLEIAGVPGDAREVTGVAVGRPHIASAMVELGVVATVSDAFTPEWLAGDGRAYVEKHESDPFEAIRLVKAAGGVTVLAHPLALKRGQCVSESAIAELASAGLDGVEVDHMDHDAATRARLRGLASDLGLLTTGSSDYHGSRKTCGLGDFTTDPEIYGEITRRATGAFPVPGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XED9</accession>
    <name>A0A2G1XED9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26280</name>
        <name evidence="2" type="ORF">CYQ11_19360</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49539">
        <property type="protein sequence ID" value="PHQ49539"/>
        <property type="gene ID" value="BLA24_26280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14741">
        <property type="protein sequence ID" value="PPT14741"/>
        <property type="gene ID" value="CYQ11_19360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="133" mass="14693" checksum="03402323EA87FE6E" modified="2018-01-31" version="1">MTVPWTLGDITDALRGAWAADTCSPDDAAREPWGSGNPAWGHCDVTALVVNDIFGGDLLVGEVYLDGEQHGFHWWNRLPSGVDVDLTREQFRRGQRVTGARVVKRPAGPLPRRHEEYVLLRERVAARLGPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEN2</accession>
    <name>A0A2G1XEN2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyraldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_23165</name>
        <name evidence="7" type="ORF">CYQ11_22910</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49686">
        <property type="protein sequence ID" value="PHQ49686"/>
        <property type="gene ID" value="BLA24_23165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16737">
        <property type="protein sequence ID" value="PPT16737"/>
        <property type="gene ID" value="CYQ11_22910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="483" mass="51855" checksum="297275AAF1A9C238" modified="2018-01-31" version="1">MTTELRRLRNYIDGEFRDAVDGRTTEVVNPATGEAYATAPLSGPADVDAAMAAAEAAFPAWRDLVPAERQKVLLKIADAFEARAEDLIAAESENTGKPLALTRSEEVPPMVDQIRFFAGAARLLEGRSAGEYMEGMTSIIRREPVGVCAQVAPWNYPMMMAVWKFAPALAAGNTVVLKPSDTTPASTVLIAEIIGGVLEELGHPKGVFNVVCGDRDTGRLMVEHSVPAMASITGSVRAGMSVAESASKDLKRVHLELGGKAPVVVFEDADIAKAVEDIAVAGYFNAGQDCTAATRVLVHESVHDEFVTALAKAAADTKTGQPDDEDVLYGPLNNANQLQQVTGFIERLPAHAKVEAGGHRVGEKGYFYAPTVVSGLKQDDEIVQHEVFGPVITVQSFTDEQQAVSYANGVEYALASSVWTKDHARAMRMSKALDFGCVWINTHIPLVAEMPHGGFKKSGYGKDLSAYGFEDYTRIKHVMTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF69</accession>
    <name>A0A2G1XF69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19785</name>
        <name evidence="5" type="ORF">CYQ11_11005</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49880">
        <property type="protein sequence ID" value="PHQ49880"/>
        <property type="gene ID" value="BLA24_19785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13344">
        <property type="protein sequence ID" value="PPT13344"/>
        <property type="gene ID" value="CYQ11_11005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="231"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="441" mass="46229" checksum="059F8C4E3D2B0FF9" modified="2018-01-31" version="1">MNRPPLPRGAAYAVLAALAAVVIVVSTAIFLGVGGPGDDSDRGPRAPRRSAAPAVTGGWTGSWSTSPAAAEPNTAHGFADQTIRNVVHTTLAGSSARIQLSNLYGTQPLAISHATLALAAAPHSPAAEPGSMRPITFGGQPTAIIPAGQALVSDPVRFTVPYAADLLVTTYSPTPSGPATFHPHARQTSYLADGDQADATDGAPFVTRTTYWRYLTGVDVWNSEAHGSVAVLGDSITDGVSATVDADHRWTDYLAARLNSEPGAPRYGVLNEGISGNRVLLSGQGASPTANPSALERFDRDVLSRAGVRVVVVELGINDILRQPQQADPGRITAGLRQLVDRAHLRGLRVIGSTLTPFGGRTGAGPQHEAVRQGVNEEIRAGRVFDDVVDFDQALRDPEQPQRLLPAYDCGDHLHPSDAGYRAMADTLDVEKLKAQPAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF73</accession>
    <name>A0A2G1XF73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19830</name>
        <name evidence="3" type="ORF">CYQ11_10960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49888">
        <property type="protein sequence ID" value="PHQ49888"/>
        <property type="gene ID" value="BLA24_19830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13336">
        <property type="protein sequence ID" value="PPT13336"/>
        <property type="gene ID" value="CYQ11_10960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="65" mass="7080" checksum="FCCDDB3538BB10E2" modified="2018-01-31" version="1">MTITPQALWHKSSYSSGGDNCVEVATQAHPAPIAIRDSKHPHGPLLTFSPAEFRFFTRALTDGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD6</accession>
    <name>A0A2G1XFD6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent RecD-like DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recD2</name>
        <name evidence="5" type="ORF">BLA24_20225</name>
        <name evidence="6" type="ORF">CYQ11_10565</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecD family. RecD-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49948">
        <property type="protein sequence ID" value="PHQ49948"/>
        <property type="gene ID" value="BLA24_20225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13275">
        <property type="protein sequence ID" value="PPT13275"/>
        <property type="gene ID" value="CYQ11_10565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01488">
        <property type="entry name" value="RecD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006345">
        <property type="entry name" value="DNA_helicase_RecD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041451">
        <property type="entry name" value="RecD-like_SH13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18335">
        <property type="entry name" value="SH3_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01448">
        <property type="entry name" value="recD_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_4" evidence="3">
        <location>
            <begin position="144"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SH3_13" evidence="4">
        <location>
            <begin position="573"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD_C_2" evidence="2">
        <location>
            <begin position="658"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="360"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="750" mass="80271" checksum="368E7FF540E5FCB2" modified="2018-01-31" version="1">MVQLAVVEGVLERITYANEDSGYTVARVDTGRGGGDLLTVVGALLGAQPGESLRLEGRWGSHPQYGRQFTVENYTTLLPATIQGIRRYLGSGLIKGVGPRIADRIVTHFGTDTLDVIEQEPERLIEVPGLGPKRTKSIGAAWEEQKAIKEVMVFLQGVGVSTSIAVRIYKKYGDASISVTRNEPYRLAADVWGIGFLTADRIAQSVGIPHDSPERVKAGLQYALSQSTDQGHCFLPEERLIADAVKLLQVDTGLVIDCLAELAAEEEGVVRETVPGPEDEGPVTAVYLVPFHRAELSLAGQLTRLLRTDADRLAGFQDVDWDKALTWLAGRTGAELAAEQQQAVRLALTSKVAVLTGGPGCGKSFTVRSVVELARAKKAKVVLAAPTGRAAKRLSELTGADASTVHRLLELKPGGDAAYDKDRPLDADLVVVDEASMLDLLLANKLVKAVPPGAHLLLVGDVDQLPSVGAGEVLRDLLAPGSPVSAVRLTRIFRQAQQSGVVTNAHRINSGVPPITLGMTDFFLFAEEDTEEAGRLTVDVAARRIPAKFGLDPRRDVQVLAPMHRGPAGAGTLNGLLQQAITPARPDVAERRFGGRVFRVGDKVTQIRNNYEKGQNGVFNGTVGVVTALDVVEQRLTVRTDEDEEVGYDFDELDELAHAYAVTIHRSQGSEYPAVVIPVTTGAWMMLQRNLLYTAVTRAKKLVVLVGSRRALGQAVRTVSAGRRCTALDHRLGGGFPGGGTGGGKGGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFF0</accession>
    <name>A0A2G1XFF0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="4" type="ORF">BLA24_19660</name>
        <name evidence="5" type="ORF">CYQ11_11135</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49859">
        <property type="protein sequence ID" value="PHQ49859"/>
        <property type="gene ID" value="BLA24_19660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13365">
        <property type="protein sequence ID" value="PPT13365"/>
        <property type="gene ID" value="CYQ11_11135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="3">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="103" mass="11611" checksum="DF87272B495458A9" modified="2018-01-31" version="1">MGNVSVAPVEIERPETGESPYAVAEPDVPWVTLVHNDPVNLMSYVTYVFQAYFGYSKDKAHRLMLDVHHKGRATVSSGSREEMERDVQAMHGYGLWATLSQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFH9</accession>
    <name>A0A2G1XFH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20450</name>
        <name evidence="3" type="ORF">CYQ11_10335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49988">
        <property type="protein sequence ID" value="PHQ49988"/>
        <property type="gene ID" value="BLA24_20450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13235">
        <property type="protein sequence ID" value="PPT13235"/>
        <property type="gene ID" value="CYQ11_10335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="8347" checksum="1D0A72CB6D1C4496" modified="2018-01-31" version="1">MNPDLLAAGVLLGPGLILGPVCLFGHRLARRHDEAAAAAIAAFRPTPPTPAPVPPSPGEPQPVAVVVHLDAHRRRTRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFI0</accession>
    <name>A0A2G1XFI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19835</name>
        <name evidence="4" type="ORF">CYQ11_10955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49889">
        <property type="protein sequence ID" value="PHQ49889"/>
        <property type="gene ID" value="BLA24_19835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13335">
        <property type="protein sequence ID" value="PPT13335"/>
        <property type="gene ID" value="CYQ11_10955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="9174" checksum="CB53ABE003ECB588" modified="2018-01-31" version="1">MLHNRLSAHRWRKSSYSGDQNPSCLEWQHTPDGSIAIRDSKTPSRGGFLFRREAWSAFVIALQSESAEASKLRSEQEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFK6</accession>
    <name>A0A2G1XFK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20655</name>
        <name evidence="2" type="ORF">CYQ11_10125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50024">
        <property type="protein sequence ID" value="PHQ50024"/>
        <property type="gene ID" value="BLA24_20655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13198">
        <property type="protein sequence ID" value="PPT13198"/>
        <property type="gene ID" value="CYQ11_10125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="208" mass="22736" checksum="CF1C294F0FFF5234" modified="2018-01-31" version="1">MDQTDLTRPLGRDGGWPEAEAPCANAAYGELPVRAYDLLTLALCHVLGALWALLGLRRAAGALRHYLRRSGTPYRVDAEALLTLPAVRAAADGQLARWRAEALARWRAGPGGPAAYPADSGWRDVLLTREVSTDWWLALRCAEFRLTGTVRVDAAGHTAVDYRFAVQKAWNFDRGKSELGVPFAPFARLHETGLAREFLVTGEAFGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFM8</accession>
    <name>A0A2G1XFM8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Trigger factor</fullName>
            <shortName evidence="6">TF</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tig</name>
        <name evidence="11" type="ORF">BLA24_20795</name>
        <name evidence="12" type="ORF">CYQ11_09985</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 8">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50046">
        <property type="protein sequence ID" value="PHQ50046"/>
        <property type="gene ID" value="BLA24_20795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13175">
        <property type="protein sequence ID" value="PPT13175"/>
        <property type="gene ID" value="CYQ11_09985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="50180" checksum="C45D6675C0EDB655" modified="2018-01-31" version="1">MKSAVETLNPTRVRLTVEVPFEELKPSLDAAYKKINQQVTVKGFRQGKIPARVIDQRFGRGAVLEEAVNDALPKLYTEAVNEAELNPLGQPEVDITELKDGELLAFTAEVDIRPALEIPDYSGIEVTVDAVEVTDEDLEKSVEQLRERFATTSPVERAAAEGDIVTVDLEAKVEGEVLEDGVASDVDYTIGSGQLLEGIDDAVTGLEAGGTATFTSELKGGSAEGKEAEITVVVKAVKARELPELDDDFAQMASEFDTLDELKADSRKRLERMKKFDQATQAQEKVLEELLKLVEVPMPEKLLADEVNTRKHNLEHHQLGQIGMTLDKYLEMQGKSAEEFEAELKEQAEKGIKTQFVLDEIVNKEKVSVGQEELTEHLMRRAQSSGMAPDQFAQAVVEQGQVPMLVGEVARGKALATVVEAATVKDSNGEVVDLEDEDETETAVETVEAAEAGDEKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGG8</accession>
    <name>A0A2G1XGG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_22525</name>
        <name evidence="8" type="ORF">CYQ11_08265</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50324">
        <property type="protein sequence ID" value="PHQ50324"/>
        <property type="gene ID" value="BLA24_22525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12889">
        <property type="protein sequence ID" value="PPT12889"/>
        <property type="gene ID" value="CYQ11_08265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="185"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="407" mass="45416" checksum="0E0BEEE5FE3C189B" modified="2018-01-31" version="1">MAGHIQDRWYKTEPGPSGKPVKTKTDRHGIGLRYRARYVGPDGTEKSKSFPDKQKRRAETWLSTIETDMARGQYIDPTAGRITFRDFASDWMASQTTDPATRQAVELRLRLHAFPHLGSRSMSAFAPGNIRAWARALQDSGMAPTYQRVVFANVSSVFTAAVDDGLIARNPCRARSVRAPKVERRKVQPWSHERVRTVRLGLPEQYRLTVDLGAGCGLRQGEVFGLAVDDVDFLGGVVHVVRQVKMIGAELVFAPPKGGKIRDVPLADVTSTALTQHITRRPPLEVTLPWKTPDGPPVTASLLLYTRERKALNRNYFNMYLWKPALVAAGAIPERQPGERFKESREHGMHALRHYYASVLLDAGENVKALAEYLGHSDPGFTLRTYTHLLPNSSERARRAIDAAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGH4</accession>
    <name>A0A2G1XGH4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">BLA24_22600</name>
        <name evidence="17" type="ORF">CYQ11_08190</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50336">
        <property type="protein sequence ID" value="PHQ50336"/>
        <property type="gene ID" value="BLA24_22600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12875">
        <property type="protein sequence ID" value="PPT12875"/>
        <property type="gene ID" value="CYQ11_08190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="9"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="341"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ50336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="462" mass="48545" checksum="BEB39A3824497732" modified="2018-01-31" version="1">MANDASTVFDLVILGGGSGGYAAALRGAQLGLDVALIEKDKLGGTCLHRGCIPTKALLHAGEVADQAREAEQFGVKASLEGIDIAGVHKYKDDVISGLYKGLQGLVASRKVTYITGEGRLSSPTSVDVNGERVHGRHVLLATGSVPKSLPGLTIDGDRVISSDHALVLDRVPKSAIVLGGGVIGVEFASAWKSFGVDVTIVEALPHLVPVEDENSSKLLERAFRKRGINFSLGSRFSGVEYTADGVKVSLENGKTFEAELLLVAVGRGPVSQGLGYEEAGVAMDRGYVLVDEYMQTNVPTISAVGDLVPTLQLAHVGFAEGILVAERLAGLKPVPVDYDGVPRVTYCHPEVASVGITEAKAKELYGADKVVALKYNLAGNGKSKILKTAGEIKLVQVRDGAVVGVHMVGDRMGEQVGEAQLIYNWEALPAEVAQLIHAHPTQNEALGEAHLALAGKPLHSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGZ2</accession>
    <name>A0A2G1XGZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16865</name>
        <name evidence="4" type="ORF">CYQ11_16420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50502">
        <property type="protein sequence ID" value="PHQ50502"/>
        <property type="gene ID" value="BLA24_16865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14242">
        <property type="protein sequence ID" value="PPT14242"/>
        <property type="gene ID" value="CYQ11_16420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="340" mass="37305" checksum="1019FAEC5B1EB395" modified="2018-01-31" version="1">MTVPDTPAAPPSPEPDRPAPHPAAGSPAPGPGAPGVSPTAVVRAEGPWTHRDVAANGARFHIAEMGEGPLVLLLHGFPQFWWTWRHQLPALAEAGFRAVAMDLRGVGGSDRTPRGYDPANLALDITGVVRSLGEPDAALVGHDLGGYLAWTAAVMRPKLVRRLVVSSMPHPRRWRSAMVGDPKQSAASSHIWGFQRPWLPERRLVADDAALVGRLIRDWSGPRLPDDAAVDTYRQAMSIPSTAHCSIEPYRWMVRSLARPDGLQFNRRMKMPVRVPTLHLHGSLDPVMRTRSAAGSGEYVEAPYRWRLLDGLGHFPHEEDPAAFSAELISWLKDTEPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHA3</accession>
    <name>A0A2G1XHA3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_16975</name>
        <name evidence="11" type="ORF">CYQ11_16305</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50519">
        <property type="protein sequence ID" value="PHQ50519"/>
        <property type="gene ID" value="BLA24_16975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14226">
        <property type="protein sequence ID" value="PPT14226"/>
        <property type="gene ID" value="CYQ11_16305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="79"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="36630" checksum="E229670944EE0CB4" modified="2018-01-31" version="1">MPLSPTRSTTVTPSAPVLPPQGYDGTSPFPQDGPAPARDGGERLYVTVTAVIVVLPFVAIGLAGWLLWGSLIHPADIVLALVLYAITGLGVTVGFHRGLTHVGYRAVRPVRIALAVAGSMSFQGDVIGWVAIHRRHHAFTDRPGDPHSPYRYGTHLRGQLRGLLHAHVGWLFRNDHTPPERYAPDLLADRDIRAVARAFPALCVLTLALPFAVGWVIGGTWLYGVTALLWAGLVRIALLHHVTWSVNSLCHMVGERPFRTRRHDRATNLWPLALLSFGESWHNLHHADPTSARHGVDRGQLDPSAAVIRLLERLGWVHDVRWPTPDRVAARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHJ9</accession>
    <name>A0A2G1XHJ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18110</name>
        <name evidence="5" type="ORF">CYQ11_15165</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50702">
        <property type="protein sequence ID" value="PHQ50702"/>
        <property type="gene ID" value="BLA24_18110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14044">
        <property type="protein sequence ID" value="PPT14044"/>
        <property type="gene ID" value="CYQ11_15165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="19046" checksum="AD94EC85939A6E11" modified="2018-01-31" version="1">MSELTLTVMRLGFLAVLWLFVIVAVQVIRSDLFGTRVTQRGSRRGAGGGQAQRAQQAAPPQQRQQQSGGRRADRGRRGAPTKLVVSEGTLTGTTVALQGQTISLGRAHDSTIVLDDDYASSRHARIYPDRDGQWIVEDLGSTNGTYLDRTRLTTPTPIPLGAPIRIGKTVIELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK2</accession>
    <name>A0A2G1XHK2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18135</name>
        <name evidence="2" type="ORF">CYQ11_15140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50705">
        <property type="protein sequence ID" value="PHQ50705"/>
        <property type="gene ID" value="BLA24_18135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14041">
        <property type="protein sequence ID" value="PPT14041"/>
        <property type="gene ID" value="CYQ11_15140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="94" mass="10194" checksum="6892DBC768E3D077" modified="2018-01-31" version="1">MAGGAKSDGRARSGGRFERVTVNLAPRSSAALEHAAMITGDTKTDTINRALQIYAMLADVVDNGGAVLVRYTPDGELERQRLFPERFDRVTTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK5</accession>
    <name>A0A2G1XHK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18265</name>
        <name evidence="5" type="ORF">CYQ11_15010</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50728">
        <property type="protein sequence ID" value="PHQ50728"/>
        <property type="gene ID" value="BLA24_18265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14016">
        <property type="protein sequence ID" value="PPT14016"/>
        <property type="gene ID" value="CYQ11_15010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304650" evidence="3">
        <location>
            <begin position="28"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="183" mass="18105" checksum="00E42BADBC72BADF" modified="2018-01-31" version="1">MRGSGPLAGPALAAVVSVLIAPWPARAGQPGPAAPEPPPSVAATTATTVFPSAPPSPGADALAGTVAGEGRIHPGRSSGPPEAGAAASPSPVPTGRGTPDRRHGAHQPPGEAVPGEEEDGAVDEPDDLPPASYGAVPLPAPEHAPPRETQGSTDRVMRVLPLGTGMALTGLGLGFIALRLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHM9</accession>
    <name>A0A2G1XHM9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18305</name>
        <name evidence="3" type="ORF">CYQ11_14970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50735">
        <property type="protein sequence ID" value="PHQ50735"/>
        <property type="gene ID" value="BLA24_18305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14008">
        <property type="protein sequence ID" value="PPT14008"/>
        <property type="gene ID" value="CYQ11_14970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="326" mass="35476" checksum="492A506110623531" modified="2018-01-31" version="1">MSIEKLTIAKAINASLRTALETDPKVLVMGEDVGKLGGVFRVTDGLQKDFGEERVIDTPLAESGIVGTAIGMALRGYRPVVEIQFDGFVFPAYDQIVTQLAKMHARALGKIKLPVVIRIPYGGAIGAVEHHSESPEALFAHVAGLKVVSPANASDAYWMLQQAIQSDDPVIYFEPKRRYHDRAEVDTAAIPGPLHTARTVREGTDLTLVAYGPMVKTCLEAAAAAEEEGKSLEVLDLRSISPIDFDAIQRSVEKTGRLVVVHEAPVFFGSGAEIAARITERCFYHLEAPVLRVGGYHAPYPPSRLEDEYLPGLDRVLDSVDRALAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI09</accession>
    <name>A0A2G1XI09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17460</name>
        <name evidence="4" type="ORF">CYQ11_15815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50882">
        <property type="protein sequence ID" value="PHQ50882"/>
        <property type="gene ID" value="BLA24_17460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16590">
        <property type="protein sequence ID" value="PPT16590"/>
        <property type="gene ID" value="CYQ11_15815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="362"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="448" mass="43366" checksum="C947DF4ECC2AC869" modified="2018-01-31" version="1">MPPAAAAPGDPAQQQAAFAAAGASGPGPAGTSGAAGAWYGGADAPPPYGGAAGGAPGGPATPWGAPPPPPPRKRSGGLVAAVLAAALLAGGIGGGVGYWAADRNGSDGSTTVSSSGDPKTESRAPGSVADIAGKALPSVVTIEAQSNSGEGGTGTGFVYDKQGHILTNNHVVASAAEGGKLQATFSDGKSYDAEVVGRAQGYDVAVIKLKDPSGAKLNPLPLGDSDKAAVGDATVAIGAPFGLSGTVTTGIVSAKKRPVASSDGGGGGQASYMSALQTDASINPGNSGGPLLNAQGAVIGINSAIQSAGNGGGFGGGQTQSGSIGLGFAIPINQAKNVADQLIRNHTPIYPVISATVNMKDSGTGAKIAANGANGSPAVTPGGPADKAGLKSGDVIVKLDDTKIDSGPTLISEIWTHQPGDKVTVTFIRDGKQSTTEITLGERRGDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI46</accession>
    <name>A0A2G1XI46_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_18200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50897">
        <property type="protein sequence ID" value="PHQ50897"/>
        <property type="gene ID" value="BLA24_18200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="7">
        <location>
            <begin position="29"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="435" mass="46930" checksum="1120C64DE884E7C4" modified="2018-01-31" version="1">MVAGHRRRPRGGEQPMINALSRGLDRVTGASLGPYQTAVVRIGLSFTWLCYLLREWPNRHELYGPDAPWSWGMARELTGDNHAFTALMWSGSATWFETVYVLALVSAALLTLGWRTRTMSVLSMVTVLSLQNRSVFIGDGGDNVIHLMALYLVLTRCGQVWSLDARRAARRASDRGSGSGSGSEAGAASGSGPRGAGWDVTGVVLWTACGLALATAQLVCDTGMSWTADGPLPGIGWAAALWGLWAVQGLWWAVARFAPGEPRTVLDALAHLAHNATLLVIMAEVCLIYATAGWYKIQGTRWQDGTALYYPLHIDYFSPWPGLSHALAGNGLVVLLLSYGTVAVQVAFPFTLLNRRVKNVLLPVMMAEHVGIAVLLGLPFFSLAMIMTDAVFLPTSFLRRVGDLAGRARSRLRASRTGGVPQQRDTEPTRAAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI69</accession>
    <name>A0A2G1XI69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18600</name>
        <name evidence="2" type="ORF">CYQ11_14680</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50910">
        <property type="protein sequence ID" value="PHQ50910"/>
        <property type="gene ID" value="BLA24_18600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16565">
        <property type="protein sequence ID" value="PPT16565"/>
        <property type="gene ID" value="CYQ11_14680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="60" mass="6576" checksum="92CE512658A16E58" modified="2018-01-31" version="1">MGKGSSMERTVVRCAEGHVFSTASFPMQHLGAGRIGPGRLLRCPRCARLRHSVPVDLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ5</accession>
    <name>A0A2G1XIJ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15005</name>
        <name evidence="3" type="ORF">CYQ11_13065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51082">
        <property type="protein sequence ID" value="PHQ51082"/>
        <property type="gene ID" value="BLA24_15005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13695">
        <property type="protein sequence ID" value="PPT13695"/>
        <property type="gene ID" value="CYQ11_13065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009452">
        <property type="term" value="P:7-methylguanosine RNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="325"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="42511" checksum="44DCDAC6C9514EAB" modified="2018-01-31" version="1">MGHVPAPNAATDAFTALLTDEGRRLLDGLRDYDPARELATATRLRREHPAELVSAALGQARLRQRAVAKFGAEDAYRMFFTPHGVEQATRASVALHRARRFEALGVRRLADLCCGNGGDAIALARAGISVLAVDRDPLTCEVARANAEALGLSDLIEVRCADVADVDTSTYDAVFVDPARRGGRGRIFDPEAYSPPLSWAVEAARKAPHAALKIAPGVPHEAIPEDAEAEWISDGGDVKEAVLWFGTEPGARRATLLPSGASLVGQGLPDPSVRPMGRYLYEPDGAVIRAHLVADVAAELGDGGLVDETIAYVTSDGLRDSAYATAYEITDVLPFNLKRLKAIVRERGIGVAVIKKRGSAVEPEELRKKLKLEGANSCVIVLTRVAGAPTMLLGHPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM1</accession>
    <name>A0A2G1XIM1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_15115</name>
        <name evidence="10" type="ORF">CYQ11_12955</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51102">
        <property type="protein sequence ID" value="PHQ51102"/>
        <property type="gene ID" value="BLA24_15115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13674">
        <property type="protein sequence ID" value="PPT13674"/>
        <property type="gene ID" value="CYQ11_12955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="389" mass="42419" checksum="2B9B9035F9CAE60A" modified="2018-01-31" version="1">MDLGWTKEEEDFRLRLRAWLRTTLPGLPAKPSPDDWPARRAYDCAWQRALYEAGYAGLHWPAEAGGQGATPTQQLIYLEETERAGAPYVGANFVGLLHAGPTIAAEGTAAQRARWLPPILRGDEVWCQGFTEPEAGSDLASLRTRAVRDGDAYVVTGSKIWTSHAEIADWCELLVRTDASASGHRGISWLALPMDAPGVTVRPLRTLAGSTEFAEVFLDEVRVPVSHRVGAENDGWRVTMVTLAFERGTAFAGEVVACRRTLERLAVTAKENGRWDDAVLRRRLGRLDAEFGALWRLVQGNVSEAESSLRAGGDGVPGAGASVFKLRYSQARQDLYDAAAEVLGPLSLDADHAWTGERLTSLSYTIAAGTSQIQQNIIAERVLGLPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM7</accession>
    <name>A0A2G1XIM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14955</name>
        <name evidence="4" type="ORF">CYQ11_13115</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51075">
        <property type="protein sequence ID" value="PHQ51075"/>
        <property type="gene ID" value="BLA24_14955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13702">
        <property type="protein sequence ID" value="PPT13702"/>
        <property type="gene ID" value="CYQ11_13115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="307"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1110" mass="120563" checksum="FBDA20C7FF057DBE" modified="2018-01-31" version="1">MHPARERIAAVFGRGQGSGYLLAPDLVLTAAHVVGDCEAPTVIVPGGVGKVRCRVGWSRDDNRRCDVALLLAERDLVPPETAAAFEPLVWGRAYDLRAWPGAQAIGFPHVQRDGAGELDSEQVVGALKPGSNLLSGRHVLDSDHGAPAAPADGGSPWAGMSGAAVFVDGLLAGVVCADPGGWRHGRLTVTPSETLWQDFRFLRECVLAGHKPESRSLASPRQREVEVFERRLRDYIVGRSGELTIIGLTLGDGEGETWPLDAAYLSLELTGAGRAGAGEGFGLPGGDPAARSVPSPKRAEEALAGHRRVLLRGAAGSGKTTLLQWLATLTARGEVPPELGHLSGCIPLTLPLRTLIRRGELPRPEEFLAAAAGPLAGLPAAQGWATRRLTEGTALLLIDGVDEVPEADRRRTLAWLKDLLAAYPDARYVITTRPSAVREGWLADAGFTELELLPMSRGDVLAFIDRWHAAAGAAHDERLRSFRDALSAAVVAKRDLGRLATNPLMCALICALNRSRRGHLPHGRMELYRAALDLLLIRRDREREIVVGLEGPELEQAQVALLQKIAYWLIRNGRSEIEWHKAVEILERALPAMPAVAARGSAEQILRHLVVRSGLLRQPTSETLDFVHRTFQDYLGAQAAVDDWDFDVLVNHAHDDQWEDVLRMAVGHAPPRARAELLGMLLERGEKEETNRHRLRLLAAACLEQATEVDPAVRARVERAASELVPPRDTESAKALAEAGQIVLDLLPGPEGLSDEVAHAVVVTATTIGDDRAIPLLARYAAHPSLAVRAQLTWAWDRFDTEHYADAVISKLSYAEEGGDYLRFVAKSRRHLVVLRRMGGRPRVEYEGTPSEEDLRLLFTPVLRELAVQSADVFDLRVLSALPSLRELTVYRSKTVAHLDELDSGCLERLHFNLDEPPAGLEAVGGMTGLRYFGLTMDRSRARAGRPQTLSLPPALSALTLSAGRAVGVDLSALHHHPALEYLTYYGEDVRREELGLGTLPRLVRLHAMAEDLRTLREAEPLPGVTTLHLGHPRELGGLVHLPAAYPDVERLSIVMRHGSEEAIDLAPLRDLGRPVAVTVHHSGPVTGGDCLPEGSTLSVREAVKSAQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIN5</accession>
    <name>A0A2G1XIN5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="4" type="ORF">BLA24_15075</name>
        <name evidence="5" type="ORF">CYQ11_12995</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51096">
        <property type="protein sequence ID" value="PHQ51096"/>
        <property type="gene ID" value="BLA24_15075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13681">
        <property type="protein sequence ID" value="PPT13681"/>
        <property type="gene ID" value="CYQ11_12995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="323"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="382" mass="39993" checksum="6B6E823C0524F323" modified="2018-01-31" version="1">MAQSKSFSGRDMGIDLGTANTLVYVRGKGVVLNEPSVVAVNAEDGSVLSVGSEAKETIGRTPSNIVAIRPLRDGVIADFEIAERMLRHFIKKVMGNRRFSRPRVVVCVPSGITGVERRAVIEAAGQAGARQVHLVEEPMAAAIGAGLPVSEPTGCMVVDIGGGTTEVAVISLGGIVTARSVRTAGDAMDAAITSYVKKEYALAIGERTAEDIKMIIGSASPTTYASEAGLAALARQVAAGGGREDGGDPEETQGLRPGDRYTIRGRDQVSGLPKTLELTADEVRHALTEPVDAIVMAVRQTLDETPPELAGDIMDRGVVLTGGGALLRGLDVRLSKELDIPVLVADDPLDCVAIGTGRCVEDFTSLRTVLDAQPRMLSTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIP0</accession>
    <name>A0A2G1XIP0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-glucosamine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_15080</name>
        <name evidence="6" type="ORF">CYQ11_12990</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51097">
        <property type="protein sequence ID" value="PHQ51097"/>
        <property type="gene ID" value="BLA24_15080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13680">
        <property type="protein sequence ID" value="PPT13680"/>
        <property type="gene ID" value="CYQ11_12990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="321"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="45115" checksum="2E867C3CFDE103BC" modified="2018-01-31" version="1">MPADFAVIGLGPFGLPLAQAATAAAIPTVGYDTDSRVIAALRAGHLPTEGDGSLTAAGIRRMLSAGFRATTDDAELGRVRTAAICAPTRLGEDRALDLTAIGDAARALAARLRPHTTVLLESAVYPGTTEEFIRPILEDGSGLRAGRDFHLAYSPSRIDPGNRRHGFANTPKVIGGLTPACTEAAAAFYGRICEKVVRAKGLREAEAVKVLETNYRHVNIALANEMAVFCHDIGVDLWDVVRCAETKPFGFQAFRPGPGVGGHGVPLDPNYLSYKGRSLGYPLRMVELAQEINGRMPRYVIQRCAMLLNEHGKSARGARVLLLGVGYKADVGDEEGSPAREIAARLVEMGAQLSYHDPHVSQWRVLGQPVPRADCLYEAAAAADLTVLLQHHRTYDLQGLAVKAQLLLDTRGASPAGAAYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ43</accession>
    <name>A0A2G1XJ43_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15955</name>
        <name evidence="3" type="ORF">CYQ11_12120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51245">
        <property type="protein sequence ID" value="PHQ51245"/>
        <property type="gene ID" value="BLA24_15955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13530">
        <property type="protein sequence ID" value="PPT13530"/>
        <property type="gene ID" value="CYQ11_12120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="33123" checksum="A691A8BB08449E4B" modified="2018-01-31" version="1">MSPDGFAVVRGRGYRPEQVDRAVAEFARQRDTAWERAARLTVLAREMEDEGRRLEQVVAKLPPQTYETLGPRAQGLVTTAELEAAGLRERAEAEAAEVQESAAAYGRELREAAHEYAVAVRAEAEEWARQAQLAAQTVADDLRTTVRQETKKRREESLAALKEMRQHTAMILAEQEKEQAERWDVAGREIAEREAAMDARVAALEEYARTALGEARRRYADTEEAARHGQEDAEAQAAAVIAQARVREERIARDTERVLREHEERREELRSHMAHVRHSLAALTGKPVAEDAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJA7</accession>
    <name>A0A2G1XJA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gas vesicle protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_14535</name>
        <name evidence="8" type="ORF">CYQ11_13540</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51338">
        <property type="protein sequence ID" value="PHQ51338"/>
        <property type="gene ID" value="BLA24_14535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16539">
        <property type="protein sequence ID" value="PPT16539"/>
        <property type="gene ID" value="CYQ11_13540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="14891" checksum="5DAA869395199F94" modified="2018-01-31" version="1">MPRPDHLREPDRLREVAQAAARALSVVPAHPDELPPPLGAPGRTAAERLHTDPDTVERDLVRLVLTIVELLRQLMERQALHRVDEGDLTEEQEERLGLTLMILHDRMAELCERYGLTMDDLNLDLGPLGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJB3</accession>
    <name>A0A2G1XJB3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EPPG:FO PEP transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fbiA</name>
        <name evidence="4" type="ORF">BLA24_16370</name>
        <name evidence="5" type="ORF">CYQ11_11705</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="2.7.8.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CofD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51313">
        <property type="protein sequence ID" value="PHQ51313"/>
        <property type="gene ID" value="BLA24_16370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13461">
        <property type="protein sequence ID" value="PPT13461"/>
        <property type="gene ID" value="CYQ11_11705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>7,8-didemethyl-8-hydroxy-5-deazariboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="33388" checksum="06B5C3A3FC079362" modified="2018-01-31" version="1">MQRIVVLAGGIGGARFLRGLKAAAPEAEITVIGNTGDDIHLFGLKVCPDLDTVMYTLGGGIHEEQGWGRAGESFAVKEELAAYGVGPEWFGLGDRDFATHIVRTQMLGAGYPLSAVTEALCARWRPGVRLLPMSDDRVETHVLIDDPEGGGARKAVHFQEYWVRMRAAVPAHAIVPVGAEQAKPAPGVLEAVAAADVVLFPPSNPVVSVGTILGVPGVREAVANAAAPVVGLSPIVGGAPVRGMADKVLAAVGVESTAAAVARHYGAGLLDGWLVDSVDSEAVAEVETAGIRCRAVPLMMTDVEATAEMARQALALAEEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJC0</accession>
    <name>A0A2G1XJC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15365</name>
        <name evidence="4" type="ORF">CYQ11_12710</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51354">
        <property type="protein sequence ID" value="PHQ51354"/>
        <property type="gene ID" value="BLA24_15365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16522">
        <property type="protein sequence ID" value="PPT16522"/>
        <property type="gene ID" value="CYQ11_12710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="22517" checksum="2FD3D7A114E5B031" modified="2018-01-31" version="1">MTAAVLAAALATGGWLVAHGARDHAPPPQPSRAEAFPAPGEPLLAPGRGERLVPPLPAAPPTRVRIPAIQVDAPLMPLGLLPDRTLAGPPEGDKNLAGWYAGGTPPGSAGTAVVAGHVDTDSGPAVFYNLGALKKGHEVEVARADGRTAVFVIDAIEVYARADFPSAKVYGASRRAEIRLITCGGGFSQEAGAYLGNVVVYAHLAGVRRPPQIAQRAGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJJ6</accession>
    <name>A0A2G1XJJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13970</name>
        <name evidence="2" type="ORF">CYQ11_01665</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51434">
        <property type="protein sequence ID" value="PHQ51434"/>
        <property type="gene ID" value="BLA24_13970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11775">
        <property type="protein sequence ID" value="PPT11775"/>
        <property type="gene ID" value="CYQ11_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="326" mass="33262" checksum="3524D0F73FC7019C" modified="2018-01-31" version="1">MRLQPPQQGRLSIGLDVGGTKIAAGVVDADGEVVERVPPLPSSATDQAAMLRTLSAVVEELRTRHPGVVAIGVGAAGLVHWPEGRIRTAPNNTYRDLPLRHVLQDSTGLPTVVDNDANAACWAEYRKGHSASYMAFITVGTGVGGGVVLADRLFRGRTGIAMEIGHMIVDPHGGERCGCGNTGCLEPLASGPALGRYGSAAAAAEPGGMLATLAGDPAKVTGETVSAAALAGDPGALAQLERLGGWLGIGVATLVNLFDVELVVVGGGVAEVGDPLLAPIRSHFARFVTAAGHRELPDIRPARLGPEAGWIGAALLALDQEEAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJN4</accession>
    <name>A0A2G1XJN4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="11">BCAT</shortName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ilvE</name>
        <name evidence="12" type="ORF">BLA24_13985</name>
        <name evidence="13" type="ORF">CYQ11_01680</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 11">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51437">
        <property type="protein sequence ID" value="PHQ51437"/>
        <property type="gene ID" value="BLA24_13985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11778">
        <property type="protein sequence ID" value="PPT11778"/>
        <property type="gene ID" value="CYQ11_01680"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT11778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="305" mass="33330" checksum="3FC1ED7B2F91118B" modified="2018-01-31" version="1">MALTEAEYIWMNGELVPWGDARVHVLTHGLHYGTGVLEGTRVYATPDGPAVFRLDDHIDRLYRSAHIMRMRLPYGKEQLRQASLELVRSNGHQACYLRHLANVGYGAMGIDPRANPIDVMVASWEWGAYLGEEAVQRGVRLMVSSWRRNDANVVPPVAKATGPYLNSVLAKLEALEAGFDEAVLLSGTGMVSECSGENIFVVVDGTLITPPVNAGALQGITQSTVFTLAAELGLPVRVDNLVRSDLYTADEVFLSGTAAELTPVRSIDHREVGEPGPITRQLMGLFDDVVHGRSPLSEKWLTRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJP3</accession>
    <name>A0A2G1XJP3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13810</name>
        <name evidence="2" type="ORF">CYQ11_01505</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51453">
        <property type="protein sequence ID" value="PHQ51453"/>
        <property type="gene ID" value="BLA24_13810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11747">
        <property type="protein sequence ID" value="PPT11747"/>
        <property type="gene ID" value="CYQ11_01505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="53928" checksum="36AF99B2ECF29535" modified="2018-01-31" version="1">MTTFVLVPGPHCGGWVWEGVTARLREAGAEVHPVTLTGLGDRRDLAGPGTDLETHIEELARLLDRIDAPQVVIAGHGAGIHPVLGVADRRPDRVGRIVHVDAGMPRDGESVLDLMPDPAARERLLDRAEDGWRVPPPTAAEWPARGSTAGVPDDELARLVRLAAPQPVRTLDQPLRLSGRADGVPTTGVLCTANGSSIAMVELVMSMGDPRYRKLTDPRVTFFELDTGHWPMLSTPDELAGVLLRAAAGEGRRVTVTPCERPVHPRPFLLDVPERPRERTGRIDLYPPDADEPRPAVVFVHGGPVPESAQPTPRDWPSFVGYGRYAASLGAVGVTLDHRLHGLGDYGRAAQDVAEAVELVRADPRVDGQRVALWFFSAGGLLSADWLAAPPPWLRCVAATYPVLAPLPGWGLADSRFRPAVAVRAAERPPIVLTRVGLENAQIAGTVEEFLRAAEDCDAEVEVIDVPLGHHGFETIDHTAQTRHAVERAMGSVLRHLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJQ2</accession>
    <name>A0A2G1XJQ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat-shock protein Hsp20</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_10665</name>
        <name evidence="4" type="ORF">BLA24_13170</name>
        <name evidence="6" type="ORF">CYQ11_00890</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51463">
        <property type="protein sequence ID" value="PHQ51463"/>
        <property type="gene ID" value="BLA24_13170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51910">
        <property type="protein sequence ID" value="PHQ51910"/>
        <property type="gene ID" value="BLA24_10665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11646">
        <property type="protein sequence ID" value="PPT11646"/>
        <property type="gene ID" value="CYQ11_00890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="143" mass="15987" checksum="A9CD24F3D8D26279" modified="2018-01-31" version="1">MLMRTDPFRELDRLAQQMMGPGTWSRPSAMAMDAYREGDEYVVAFDLPGVSAEAIDIDVERNMLTVKAERRPLAKADHVQMELSERPLGVFSRQIVLADTLDTEHIQADYDAGVLTLRIPIAERAKPRKISIGGESSRKEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJR6</accession>
    <name>A0A2G1XJR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Teichoic acid biosynthesis protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13295</name>
        <name evidence="3" type="ORF">CYQ11_01015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51482">
        <property type="protein sequence ID" value="PHQ51482"/>
        <property type="gene ID" value="BLA24_13295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11664">
        <property type="protein sequence ID" value="PPT11664"/>
        <property type="gene ID" value="CYQ11_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758874" evidence="1">
        <location>
            <begin position="36"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="329" mass="35234" checksum="43BBDE0E842DC26C" modified="2018-01-31" version="1">MSRIAGFSRRSLLRAGSGLGLAAFGLGTAASPASAAVPASQRFDLTQASTDLYRGKPLHDVTVQQGFAFDNVNRRLFVAQRRNGSADAAGDLCVTQLDFAGNYVGYMHLTGFGHGVAFGAQGVGSSTYLWTEVDADNGYGQRLARFKFTSGTTLSHTSSALTKYTPVAAATEHTCSIDPVNNRLIVRYQLGDGKHIAVYDLAAATNGDFSNPLADFKQPTLPTASSKFQGYAAYGQYLYVMTGDDYETNGKDSDGNWIVDSEITSIDMNTGTIKQGPVLTKAGSTLDFREPEGLAVYQTVAGDVRLFLGFASGLENDRRSNLFYKDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJW8</accession>
    <name>A0A2G1XJW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13595</name>
        <name evidence="2" type="ORF">CYQ11_01315</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51533">
        <property type="protein sequence ID" value="PHQ51533"/>
        <property type="gene ID" value="BLA24_13595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11717">
        <property type="protein sequence ID" value="PPT11717"/>
        <property type="gene ID" value="CYQ11_01315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="421" mass="45903" checksum="92F6321188DA280E" modified="2018-01-31" version="1">MRVLLGAQNCGFGPASVLVAVSRLLPGHERVFVGDGVAAAFARRNAAAFDSVHALTGPEGGQGTLLDRVLEDSDQVVSAMDADLVLRAVVAGRPVVLVDCLFSFWRHRHSLARLRELCATMPRTCLSAARRHLSGLSPHEHVLAAHLLADHSVVQNFPGVARRMAALADAGADCAMRLTGAVVDLDGLREARAEGPAGSGPDYDLLINTGGFKNFLLDYDVHNDYLRLIDRWLPDLLRDWPRFTRVLLCGGPYAGERGTTLRTAGRRVDRRCLPQRELLRQVARTPHYLLAPGLSALHEATFLGRLPLGLPEQHYAHVFTLRHLAGTLFGDQAGRFTDVLPGHALPEDDYAGTEALVAVASRIREDDGLYAKFRATFNERLERYLHLTPEQRRNGAAELRHVLDGPPAASVIAALLASRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJX5</accession>
    <name>A0A2G1XJX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13350</name>
        <name evidence="4" type="ORF">CYQ11_01070</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51542">
        <property type="protein sequence ID" value="PHQ51542"/>
        <property type="gene ID" value="BLA24_13350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16272">
        <property type="protein sequence ID" value="PPT16272"/>
        <property type="gene ID" value="CYQ11_01070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305590" evidence="2">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="22129" checksum="6A4A679B21344E65" modified="2018-01-31" version="1">MKSKIVSVLIAGSMCLVATGCGGGKSSGGGGGAKPKPAGTVLPQRLDKPPTMPDGELKPSPAAGASFSENLAYELRRKTQDMAGAPGEITAECPTDVGSKSGTKVTCKTTYEGLEVEWDVSIGDKSAFSDNLVQYKATPRQGILTRDGVARLLYGNYRDSIDYALCNDIPKAVLAPLGTQSTYACEVVFKGQKPVGFPQPVRATDSGPRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK19</accession>
    <name>A0A2G1XK19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13340</name>
        <name evidence="3" type="ORF">CYQ11_01060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51489">
        <property type="protein sequence ID" value="PHQ51489"/>
        <property type="gene ID" value="BLA24_13340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11671">
        <property type="protein sequence ID" value="PPT11671"/>
        <property type="gene ID" value="CYQ11_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304911" evidence="1">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="12964" checksum="6AABD388338D6AA8" modified="2018-01-31" version="1">MKRRSWGRGAAATVGVAALFLTIGGSVTAAAPPEAAPAPHPQRVAAVAPHPVWDTGIDIPPNTTFGTIVACPAGEVISGGGGRADVPYSLSVSDSYQEEGANSWVWAGKNVSSRTVKVKALTICTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKA8</accession>
    <name>A0A2G1XKA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11310</name>
        <name evidence="3" type="ORF">CYQ11_02545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51678">
        <property type="protein sequence ID" value="PHQ51678"/>
        <property type="gene ID" value="BLA24_11310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11927">
        <property type="protein sequence ID" value="PPT11927"/>
        <property type="gene ID" value="CYQ11_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="159" mass="17733" checksum="36C16A8E77491EE9" modified="2018-01-31" version="1">MNAERHGRDESQEERADRRWAELLQEVRVAQTGVQVLFGFLLTVAFTPRFATLGDTDRIIYVITVVLGAATTGALIGPVSFHRIVTGRRLKPETVVWVSRLTLAGVVLLLATVVSALLLILRVTLHNAAVPWVVVGLLVWFLLCWFALPGWARMRYGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKF4</accession>
    <name>A0A2G1XKF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF4040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_11485</name>
        <name evidence="10" type="ORF">CYQ11_02720</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51707">
        <property type="protein sequence ID" value="PHQ51707"/>
        <property type="gene ID" value="BLA24_11485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11956">
        <property type="protein sequence ID" value="PPT11956"/>
        <property type="gene ID" value="CYQ11_02720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="86" mass="9242" checksum="A14F12A50ACEC657" modified="2018-01-31" version="1">MREALDDLLLALALLLVATAATAAVLNREPARQAVVLSLLGLCLALLFTVLQAPDVALSQLGVGSAVTPLMILLTVRKVRRRKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKK5</accession>
    <name>A0A2G1XKK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11835</name>
        <name evidence="2" type="ORF">CYQ11_03075</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51768">
        <property type="protein sequence ID" value="PHQ51768"/>
        <property type="gene ID" value="BLA24_11835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12015">
        <property type="protein sequence ID" value="PPT12015"/>
        <property type="gene ID" value="CYQ11_03075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="466" mass="49054" checksum="FC175646F52BE9C5" modified="2018-01-31" version="1">MTAPDPGPLTGLLRRSAFAERVEHARRRSALPWEPWPPAAAAPGDDTGSALWNLLHLGRRPDRRLAPALAERLTALGLADDAGGPGRWEVTAFRGLLAARDRPAEGGEPGTGNVYVGEDSLRFVDTILRARPTGRALDVGCGSGITTCALALGCAEVTGADLQQDCLDATALTAALNGLDDRVHTWHGDFFRDHTPDAPFNCVVANLPYAPVPPALRYSAAGDGGPDGLDLNRRLLRRAAGLLDPRDGLLITRFQSLGDASGPLLLPDIEAFAKEAGHDVTVVADGRTVPEVRAALTALHARRHNPELTSAQVLDIVDDHMRRFEQPHYFACGMISRSGGTGEVTFTDLSAPLTLDDTLTAVGGAPDDAAPAAVRLYRGRALDLPDGFWELGTADDVAVTEQRLPALLAALRGAGPAGATGRDLAAEVFADRFGADPLRSRALLVTTELMAGCLADEGLVEGGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKM8</accession>
    <name>A0A2G1XKM8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11620</name>
        <name evidence="3" type="ORF">CYQ11_02860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51731">
        <property type="protein sequence ID" value="PHQ51731"/>
        <property type="gene ID" value="BLA24_11620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11979">
        <property type="protein sequence ID" value="PPT11979"/>
        <property type="gene ID" value="CYQ11_02860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758365" evidence="1">
        <location>
            <begin position="38"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="180" mass="17399" checksum="121B2677DD305F5D" modified="2018-01-31" version="1">MNTPTLLKRHRRTPANAALALALAIAGVGLWAPSATADPVSVGYTCTGPGAPDGVQSLQVTVTAPATVAQGGTAELTLEVATELKVPFGIPAQSVTGELDLQLGGAGSGRVTAGGFTNTSAIPGGSAVTLTGGTASVRLDTAGTATFSPGDAAVHVFGVTVNCTVSGTAPVAATTEVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKZ1</accession>
    <name>A0A2G1XKZ1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">BLA24_10965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000129">
        <property type="protein sequence ID" value="PHQ51908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51908">
        <property type="protein sequence ID" value="PHQ51908"/>
        <property type="gene ID" value="BLA24_10965"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="347" mass="37217" checksum="8697FF7FBF8410FB" modified="2018-01-31" version="1">MHHRADDGVQTRAVAGPPGLRTSVIRSVVHRAVVGHGDEVIGFEDGFKGLLDGRHRKLDLDAVSGILARGGTILGSSRLERARLREACESSKELAREYGIDVLIPIGGEGTLTAARMLSDAGLPVVGVPKTIDNDISSTDRTFGFDTAVGVATEAIDRLKTTAESHQRVMVVEVMGRHAGWIALESGMAGGAHGICLPERAFDPADLASMVEERFARGKKFAVICVAEGAHPAEGTMDYKKGAIDQFGHERFAGIGTKLAGELERRLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAAHRGDFGKMTALKGTDIRMVPLAEATTELKRVPENRMDEAESVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLF9</accession>
    <name>A0A2G1XLF9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gabD2</name>
        <name evidence="6" type="ORF">BLA24_10560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000124">
        <property type="protein sequence ID" value="PHQ51969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51969">
        <property type="protein sequence ID" value="PHQ51969"/>
        <property type="gene ID" value="BLA24_10560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="40"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="526" mass="56384" checksum="9D871A6E1C673DFA" modified="2018-01-31" version="1">MTAPVPVGRSDERRRRGHHSGRAPPPRWRRPDAAARRQRTSLTGDVLAELPVSTPEDVAGAFARARQAQRAWAATPVRRRAAVLLRFHDLVLARQSEVLDLIQLETGKARLHAHEEVQAVAVAARHYGHAAPALLRPKGHTGVLPLLTKATELRRPRGVVGQIAPWNYPFELSVGDALPAFAAGNAVVMKPDTQTALTALWARRLLVEAGLPEGVWQVVLGDGPVVGPAVVAHADYVSFTGSTRTGREVARGAAARLVGCSLELGGKNAMLVLRDADVEKAAAGAVRACFSSAGQLCVSIERLYVHSSLADDFLRRFTARTKAMRLGTALAYGADMGSLISARQLETVTRHVEEAVAKGATVLAGGRPRPDVGPFFHEPTILDGVEPPMAVCAEETFGPVVSVYRFDDEDEAVRRANATPYGLNASVWTTDGRRGRALAARLDAGTVNVNEGYAAAYGSARAPMGGMGDSGLGRRHGSEGLLKYTEAQTVAHQRIMPLAPAFGLDDEQYARVMTRGLRLLKAVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLV9</accession>
    <name>A0A2G1XLV9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">M56 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_08710</name>
        <name evidence="10" type="ORF">CYQ11_03970</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52235">
        <property type="protein sequence ID" value="PHQ52235"/>
        <property type="gene ID" value="BLA24_08710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12168">
        <property type="protein sequence ID" value="PPT12168"/>
        <property type="gene ID" value="CYQ11_03970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="118"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="33730" checksum="663CE642BE98FB6C" modified="2018-01-31" version="1">MMVPLALLVLGGLVAALAPRVLTRADWPDREPVLALWVWQCVVAAVLLCCALAMALSAAAAWKAVRGNVFAPAPHGVVEAYALPAYGGWAAPMALTLACGAVWTVAMLTREIHDTRARRRRQRAELLVRSPRLPGEEQGSERLVVLEGDRPEARLLRGGTAPQLVITTGALRRLRGRQLDAVLAHEQGHARARHDWLLHCSSALANGFPQVPVFAAFRDRVHHLVELAADDAASRRFGRLTTALALVELNEDRGVFGPCPTGLSQVPDRVERLLAPAPRLTAARRLRLTAVAALVPFVPVLVTFVPGLRALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLW4</accession>
    <name>A0A2G1XLW4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_08660</name>
        <name evidence="5" type="ORF">CYQ11_03915</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52228">
        <property type="protein sequence ID" value="PHQ52228"/>
        <property type="gene ID" value="BLA24_08660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12161">
        <property type="protein sequence ID" value="PPT12161"/>
        <property type="gene ID" value="CYQ11_03915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="261" mass="27492" checksum="1F4895AA8E40A7A3" modified="2018-01-31" version="1">MSLRIVVCVKYVPDATGDRHFAEDLTVDRDDVDGLLSELDEYAVEQALQIAEDADDAEITVLTVGPEDAKDALRKALSMGADKAVHVEDDDLHGTDALGTSLVLAKALEHVGYDLVVSGMASTDGGMGVVPAMLAERLGVPQVTLLSEVKVEDGKVTGRRDGDAASEQLEAALPAVVSVTDQSGEARYPSFKGIMAAKKKPVQSLDLSDLGIEADEVGLEGSWTKVDEAAERPARTAGTVVKDEGEGGKQLAEFLAGQKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLX5</accession>
    <name>A0A2G1XLX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_08560</name>
        <name evidence="6" type="ORF">CYQ11_03815</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52210">
        <property type="protein sequence ID" value="PHQ52210"/>
        <property type="gene ID" value="BLA24_08560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12143">
        <property type="protein sequence ID" value="PPT12143"/>
        <property type="gene ID" value="CYQ11_03815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASH" evidence="4">
        <location>
            <begin position="41"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="4">
        <location>
            <begin position="314"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="582"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="805" mass="83655" checksum="63623A9D62427C17" modified="2018-01-31" version="1">MAQGSVQVTHTGTSRWRRRTGEYDSLAAALEAAADGDVLSLAPGTYRENLVLTRAVTLRGAEGAPGSVRIAPTEGVAVTVRASATLLDLRIEGHDAAAPALLVEGGAPELDGLRVVTRSAAGIEVRGVSARPAVRRCVVDNPGGVGISVLDGASGVFEDCEVVAAGQSGVVVRGGAEPRLERCRVHHARGAGLSLTGEGSALEAVGCEVYEIKGTGVQVAARAAGRLSDCRVHRTSADGVTLDTDAVLALTDCAIHDVPENAVDLRSRSVLTMARSTVRRFGRNGLSVWDPGTRAEAAQCEIHESTGDYPAVWVSDGASALLGSCRVHDVPDALFVLDRGSHVDVADSDLSGVRGTAVSVSGGATVRLDDCRIREATTGVWFRGQGSGGTLAGCAIDATSTGVIVTKGADPVFERCAVTSPTEAGFYVSAEGRGTFDGCRVTGSGGYGFHVIDGCRATLTGCRTERCARGGYEFAEEGPVSEGCTSDERAAAGSGAGAVAAVVTAARPVRPASGVPQPRSPVAADPPAGAGGGAAARGAASVLGELDALVGLESVKREVRALTDMIEVGRRRREAGLKAASVRRHLVFTGSPGTGKTTVARLYGEILAALGVLERGHLVEVSRVDLVGEHIGSTAIRTQEAFDRARGGVLFIDEAYALCPEDSGRDFGREAIDTLVKLMEDHRDEVVVIVAGYTAEMERFLTINPGVASRFSRTITFGDYAPDELLCIVRQQAEEHEYRIGAGAGEALLEYFTALPKGPAFGNGRTARQTFEAMVERHAGRVAQLAAPSTDDLTLLYPEDLPELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM23</accession>
    <name>A0A2G1XM23_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08870</name>
        <name evidence="3" type="ORF">CYQ11_04125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52260">
        <property type="protein sequence ID" value="PHQ52260"/>
        <property type="gene ID" value="BLA24_08870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12192">
        <property type="protein sequence ID" value="PPT12192"/>
        <property type="gene ID" value="CYQ11_04125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="21877" checksum="ACB02DDE585C2F13" modified="2018-01-31" version="1">MAPPQEQLAEGLDPATTVLLTVECQRGVVGPGSALPELAAAARASGALANVARLVAGAHEAGVQVVHAVAERRPDGRGASRNARLFRLAERLPVQQLTGSLAVRVADPIPVGDGDLVVRRLHGLSPLAGTGVDALLRNIGCRTLVVTGVSANVAVPNAVFDAVNLGYTAVVPSDAIAGVPADYTAAVVRHTLALVASVTTTEALLHGWRRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM76</accession>
    <name>A0A2G1XM76_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2267 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07840</name>
        <name evidence="2" type="ORF">CYQ11_00275</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52355">
        <property type="protein sequence ID" value="PHQ52355"/>
        <property type="gene ID" value="BLA24_07840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11557">
        <property type="protein sequence ID" value="PPT11557"/>
        <property type="gene ID" value="CYQ11_00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="146" mass="15786" checksum="6FFD62692CDF1ABC" modified="2018-01-31" version="1">MITDVRAPLEHQPYGTAYEQMLEKVRYEGAYATRERAEEAVRLVLSGLGRQLTGDERVDLAACLPLEAARVLTVQIPDTQPLTGWAFVKDLAARSGASLATSRWDTGSVFAAVAAYAGPDLITRILHQLPTGYALLFGRAELSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM90</accession>
    <name>A0A2G1XM90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07885</name>
        <name evidence="1" type="ORF">BLA24_09970</name>
        <name evidence="2" type="ORF">BLA24_09995</name>
        <name evidence="4" type="ORF">CYQ11_00320</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000104">
        <property type="protein sequence ID" value="PHQ52027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000104">
        <property type="protein sequence ID" value="PHQ52028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52027">
        <property type="protein sequence ID" value="PHQ52027"/>
        <property type="gene ID" value="BLA24_09970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52028">
        <property type="protein sequence ID" value="PHQ52028"/>
        <property type="gene ID" value="BLA24_09995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52362">
        <property type="protein sequence ID" value="PHQ52362"/>
        <property type="gene ID" value="BLA24_07885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11564">
        <property type="protein sequence ID" value="PPT11564"/>
        <property type="gene ID" value="CYQ11_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="142" mass="15926" checksum="87D5A9416384B9FC" modified="2018-01-31" version="1">MNIQPLLEALNIQEVAARALAADLRTQVGELQTRLREAETHLEHLAITRKTVTGLADRLPAVPPDLPEHPDYPRILAVFNDTTGPLRARDVCEALDHELLPKNIEGTRAKLKRLVKLDILIEGDAGNFTRKQQPTEHRNPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMC2</accession>
    <name>A0A2G1XMC2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08060</name>
        <name evidence="2" type="ORF">CYQ11_00500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52387">
        <property type="protein sequence ID" value="PHQ52387"/>
        <property type="gene ID" value="BLA24_08060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11589">
        <property type="protein sequence ID" value="PPT11589"/>
        <property type="gene ID" value="CYQ11_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="8039" checksum="B4D506FDE5395D90" modified="2018-01-31" version="1">MSRSRAAKASYAALALAPRVPESIDWSSRTPAAAIVRAFSAASASARTSSARMKPIWDRRASRAASDAAEASSIGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMJ6</accession>
    <name>A0A2G1XMJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06645</name>
        <name evidence="3" type="ORF">CYQ11_26795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52458">
        <property type="protein sequence ID" value="PHQ52458"/>
        <property type="gene ID" value="BLA24_06645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15990">
        <property type="protein sequence ID" value="PPT15990"/>
        <property type="gene ID" value="CYQ11_26795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="7984" checksum="7B1DBECF4E391060" modified="2018-01-31" version="1">MGSPTDPRQAIMASHHSHLTPDLPPIIEVPDLPGAQHPSRSARDDSDAEPVTSSPHASGAHQEVDGRHKHAGEGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT4</accession>
    <name>A0A2G1XMT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF3516 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07240</name>
        <name evidence="4" type="ORF">CYQ11_27395</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52557">
        <property type="protein sequence ID" value="PHQ52557"/>
        <property type="gene ID" value="BLA24_07240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16095">
        <property type="protein sequence ID" value="PPT16095"/>
        <property type="gene ID" value="CYQ11_27395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="219"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="837" mass="93645" checksum="EF1F110983FB24B5" modified="2018-01-31" version="1">MTLIDQMPSHADPDALFEAFSTWAEERGITLYPAQEEALIEVVSGANVILSTPTGSGKSLVAAGAHFTALANDKVTFYTAPIKALVSEKFFDLCKIFGTENVGMLTGDASVNADAPVICCTAEVLASIALRDGRDADIGQVVMDEFHFYAEPDRGWAWQIPLLELPQAQFVLMSATLGDVSRFEEDLTRRTGRPTTVVRSATRPVPLSYEYRATPLTETLTELLQTHQAPVYIVHFTQAAAVERAQALMSINMCSREEKDEIAKLIGNFRFTTKFGRNLSRYVRHGIGVHHAGMLPKYRRLVERLAQAGLLKVICGTDTLGVGVNVPIRTVLFTALTKYDGQRVRTLRAREFHQIAGRAGRAGFDTAGFVVAQAPDHVVENEKALAKAGDDPKKRRKVVRKKAPEGFVNWTETTFEKLIASEPEQLTSRFRVTHAMLLAVIARPGNAFDAMRRLLEDNHEPRKNQLRHIRRAIAIYRSLLHGGVVEQLDEPDAEGRIVRLTVDLQSDFALNQPLSTFALASFELLDPESPSYALDMVSVVESTLDDPRQILAAQQNKARGEAVAAMKADGVEYEERMERLMDISYPKPLEELLSHAYDVYRKSHPWVGDHPLSPKSVIRDMYERAMTFTEFTSFYDLARTEGIVLRYLASAYKALDHTVPDDLKSDDFEDLIAWLGEMVRQVDSSLLDEWEQLANPAEETAEEAQERADQVKPVTANARAFRVLVRNALFRRVELAALDKVGELGELDEESGWNEDRWAEAMDAYWEEYEELGTGPDARGPKLLRIEERPEDGLWRVRQTFADPNGDHDWGITAEVDLAASDEEGRAVIRIMDVGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMU0</accession>
    <name>A0A2G1XMU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactonase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07340</name>
        <name evidence="3" type="ORF">CYQ11_27495</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52574">
        <property type="protein sequence ID" value="PHQ52574"/>
        <property type="gene ID" value="BLA24_07340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16112">
        <property type="protein sequence ID" value="PPT16112"/>
        <property type="gene ID" value="CYQ11_27495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="362" mass="37351" checksum="F625B5E3BAEDB04D" modified="2018-01-31" version="1">MTEREQRGRWAYIGSFTEAGGLGLTVAEVDGDTGALTPVHSTDAVVNPSFLTLSPGGEVLYAVSETDEGAAAAFSLADPTRPRLLGPPVPVRGDGPTHLALAGTWLFTANYGSGSVSVLPVRTGGGLGAPAAVLPHRGGGPVAERQAGPHAHAVVPDPSGRWVLAVDLGTDSVWTYALHAATGPAVAAPAPSPHRETRLRPGSGPRHLAFHPRGDRAYVLNELDSTVTTCRWDAASGHLEPIGETRVLPPGVETANFPSAPVVSADGRFLWAANRGHDSVSTLALDTTGDRPELHATVSCGGHWPRALTAHPDGRRLYAADERSGDVTWFGVDPDTGIPSRAGSVEIPAASCVVFTTGPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMW1</accession>
    <name>A0A2G1XMW1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07310</name>
        <name evidence="3" type="ORF">CYQ11_27465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52568">
        <property type="protein sequence ID" value="PHQ52568"/>
        <property type="gene ID" value="BLA24_07310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16106">
        <property type="protein sequence ID" value="PPT16106"/>
        <property type="gene ID" value="CYQ11_27465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="291" mass="31807" checksum="0F455FD541B54132" modified="2018-01-31" version="1">MNSGTPLVNFRLPTAVSGPRGRSPMRFFALLLVLSVPFWVLGAVVESPEAMPMGMPLSAFMFVCPFTAAVVLVRREEGPAGPRRLLRRLFWFRGAGNGLWFALAVLVMPVLMLASYVFLRLAGMPLDGARSPFLALPVLLVVFLVSAAGEEAGWLGYALDPLQDRWGALRAAAATGTVWAAWHVGPWLQVHGVAWTAGWFLFTVFARVLIVWLYNRTRGAVLSGILFHAMINVSSSLFPDVGAWQVPAVLAVLTAVVAGCAVLLARRPRRVLHSRRPLRQDEARTINGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMW5</accession>
    <name>A0A2G1XMW5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07435</name>
        <name evidence="3" type="ORF">CYQ11_27585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52592">
        <property type="protein sequence ID" value="PHQ52592"/>
        <property type="gene ID" value="BLA24_07435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16129">
        <property type="protein sequence ID" value="PPT16129"/>
        <property type="gene ID" value="CYQ11_27585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="18081" checksum="864B073E2D703F5B" modified="2018-01-31" version="1">MIITRPARPGDASEIVRLRRLMFAAMSGEDSPGDWERTAEEIARRQLADTSRPGLCGFVVDGDPAAGGPHLAACSLGRIEERLPAPGHPTGRFGFVFTVCTDPRYRGRGFARATTEALLELFAARGVTRVDLHATEEAEALYRSLGFAEHSTALSLDVSRWAGTVSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN31</accession>
    <name>A0A2G1XN31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_06050</name>
        <name evidence="6" type="ORF">CYQ11_03575</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52664">
        <property type="protein sequence ID" value="PHQ52664"/>
        <property type="gene ID" value="BLA24_06050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12098">
        <property type="protein sequence ID" value="PPT12098"/>
        <property type="gene ID" value="CYQ11_03575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="40673" checksum="D8EF674990CDCFAE" modified="2018-01-31" version="1">MSDTPESENWRREVDRSFSPRREAGPIDLRRYYVQPAYSGMPTFMGVPLALNQDDLRAGKVDAAVVGCPVDVSTGHRGAAYGPRAIRSDERYMYATPEAYIHSATRVNPFNVLKVVDYGDAAVDPFDITRSMEPIRGLVREIAEVGAAPIVLGGDHSLLWPSVGALSEVHGRGSIAVVHFDAHPDCHDELFGHKATHTTPIRRLMHDEMVPGANIIQVGLRTATGPDDQLFNWMRRAGMKSHFMAEIERVGLAAVVDKVIEEAKAVADHVYISLDIDVLDPAFAPGTGTPEPAGLNTRELFTALRRIAHETNLVGMDVVEVAPHLDPGYSTAMNARRAVFEVLTGLAMNKVKISTKNYTNPIVAGEVRFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNA0</accession>
    <name>A0A2G1XNA0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1206 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05475</name>
        <name evidence="4" type="ORF">CYQ11_01935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52725">
        <property type="protein sequence ID" value="PHQ52725"/>
        <property type="gene ID" value="BLA24_05475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11819">
        <property type="protein sequence ID" value="PPT11819"/>
        <property type="gene ID" value="CYQ11_01935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="108"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="203"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="28587" checksum="137D4B25022EE7D9" modified="2018-01-31" version="1">MGRWRDEGDVREARRTGTAVAARAGLVARGVLYFLVGTLALRIAVADGGEQADRGGAVQELAHKPFGHVLVWAVGVGLVGMALWQLSEAVFGAAGPDGRKVRKRSASAVRSVFFCVVAGSVIGFAAGERGSGAGSTDEKSRDVTARALDWPAGQWLVAAAGVVVAAVGVWMVVRAATRAYRRELRMAMMTPVTRRVVDVLGVVGGISRGLVFAAAGTFAVRAAVTYDPGQAKGLDDTLRTFAGSPAGPWLLAAVAVGLALFGLFSFTMARWRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNC7</accession>
    <name>A0A2G1XNC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05620</name>
        <name evidence="4" type="ORF">CYQ11_02080</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52747">
        <property type="protein sequence ID" value="PHQ52747"/>
        <property type="gene ID" value="BLA24_05620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11844">
        <property type="protein sequence ID" value="PPT11844"/>
        <property type="gene ID" value="CYQ11_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="375" mass="40258" checksum="B88449CF90947EFE" modified="2018-01-31" version="1">MIKPGRPRLRRRPDRGPLTLLSPVILTVVIATLAYTTPREVAFSRLLPAAPALAAAMWPVLPTVLLGTVCLFLMIGLGVVFPGLGTWWTASGIVAVTVAAAYGSHVRLQRERTLFQVRLVADAAQQVVLSPMPRRFGGVEIEALYLAAAAEARIGGDFYEVVDTRYGVRLLIGDVRGKGLPAVGQAAAMVNCFREAAYDEADLGSVARRLDASSTRYSAAFPPQDLMERFATALLVEIPHGGSRIGILNCGHPPPLLLSRGELRTLEPTAPSPLLNLAELTGDHYSIDSFGVVPGDLLLLYTDGVTEARDRDGEFFPLAAWMRRQAPPGPRELLGALHRDLLHYSGGGLDDDIAALAVRLREVPEPLETPGDPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNE1</accession>
    <name>A0A2G1XNE1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase family protein molybdopterin-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05510</name>
        <name evidence="3" type="ORF">CYQ11_01970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52730">
        <property type="protein sequence ID" value="PHQ52730"/>
        <property type="gene ID" value="BLA24_05510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11825">
        <property type="protein sequence ID" value="PPT11825"/>
        <property type="gene ID" value="CYQ11_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="728" mass="76914" checksum="D7C3C0BA44DF1329" modified="2018-01-31" version="1">MAHPDIGEGIDRVDARVKVSGRAAYPTDQDHPDLAHAVLVQSTVAAGRVTALDTAAAEAAPGVLAVITHENAPELHEAPDRRATLPPPPLRGDRIVHHGQTVAVVVAETFEQATEGARLVRAAYERTDPVVDIDHPGAEHVRDPFGSDDGTGDVAAALAAAPVRVEQTYRTAVNTNNPMGPFATVASWDGDQLTVHDCTQGPSRTRADLAATLKAPQDTIRVLAPYLGGGFGSGLRTWSHTVLAAVAARRVGRPVKLVLTRKQMFTSVGHRPDTRQTLKIGATRDGRITALDHEAWQTLSMGDVNTETVARVSLSGYASPAVSARDVQVRVNVPSPGSMRAPGDGQGNFALECALDELAHELGMDPLELRLRNYAGEHPVTGQRWSSNDLRECYRVGAEKFGWSRRDPAPRSMRRGRTLVGYGMAGTSFFFYQSSCAARITVNRDGGAVVASAGMDLGTGTYTVMTQLASELLALPLGRVRMVMGDSSLPQAPSAGGSGLTGAMGSAIHAASRHLIRSFLDLVRDDPGSPLRGAGTGDVRVEDGRIVREDDGRGESYEEILTRHRLDELTAEGSAEAPGEDQPVVPTGPYAAKFAEVHVDPDLGVIRVARLVTAAHCGRILNEKTARSQLVGGTVGGIGMALLEETVTEPHTGRIANGTFGDYLIAVNADIPELDVHFVGGPDPTNPTGTKGCGELGIPGTPAAIANAVFHATGTRVRHLPITIEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNE9</accession>
    <name>A0A2G1XNE9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_05330</name>
        <name evidence="11" type="ORF">CYQ11_01790</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52701">
        <property type="protein sequence ID" value="PHQ52701"/>
        <property type="gene ID" value="BLA24_05330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11794">
        <property type="protein sequence ID" value="PPT11794"/>
        <property type="gene ID" value="CYQ11_01790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="173" mass="18896" checksum="244A0C0B910D4660" modified="2018-01-31" version="1">MTTHIPASHRVHTVIDSPYGALTLVAEDGGLAGLYMEQQRHRPPEESFDERDSRPFGEVEAQLEEYFSGRRTEFDLPLRLRGTPFQRTVWEALLGIPFGSTVSYGQLAATIGRPAAARAVGLANGRNPVGIIVPCHRVLGSTGDLTGYGGGLDRKQRLLGFERQGARQLMLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH4</accession>
    <name>A0A2G1XNH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05755</name>
        <name evidence="2" type="ORF">CYQ11_02230</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52770">
        <property type="protein sequence ID" value="PHQ52770"/>
        <property type="gene ID" value="BLA24_05755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11871">
        <property type="protein sequence ID" value="PPT11871"/>
        <property type="gene ID" value="CYQ11_02230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="171" mass="19965" checksum="0616490C2871BA4A" modified="2018-01-31" version="1">MTPQPYVSTDDLKALLGDALHAEVVAHFLEKTGAAPDFVERQVTECLRYLYLVSRHRERLSGLFLPVEQEIDEIWHYLILQTREYAALCEERLPGRFLIHHRSIAYEAYQQEPGREQALEEALRWIPLYCREFGPFDEGALPHWTIVRFLHQRMDMSLEEISALEPLESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNI4</accession>
    <name>A0A2G1XNI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05965</name>
        <name evidence="3" type="ORF">CYQ11_02440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52804">
        <property type="protein sequence ID" value="PHQ52804"/>
        <property type="gene ID" value="BLA24_05965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11906">
        <property type="protein sequence ID" value="PPT11906"/>
        <property type="gene ID" value="CYQ11_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="293" mass="32309" checksum="C055DD6AA65CCA77" modified="2018-01-31" version="1">MDLESVVDELFRLRPEEFTAVRDRRAAEALRAGDRELARYVKALRRPTLAAWASNLLVRERPDEAEALTALGEGLREAHRKLDGRQLRELGRRQRVLVAALSRQAGELAAEAGHPVGEDVRREVEDTLHAALADAAAAREWAAGRLARPLAAAAGFPGLAPDAAARLAAPPAPAPPGPAHDGAAGVTDLAQARETRRAAQRHEERDRAQRQAERATRDLRACEEDLARLHDEAGRAERDVRDAQRRLDELTTVLQAARDSERDVQRRLREAEEVVRAARQAAREAETKADRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNK3</accession>
    <name>A0A2G1XNK3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05760</name>
        <name evidence="9" type="ORF">CYQ11_02235</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52824">
        <property type="protein sequence ID" value="PHQ52824"/>
        <property type="gene ID" value="BLA24_05760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16300">
        <property type="protein sequence ID" value="PPT16300"/>
        <property type="gene ID" value="CYQ11_02235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="387" mass="37562" checksum="54E19C54DDF41814" modified="2018-01-31" version="1">MLGSTGLAGVPTALFTAGSSLGAVAIGRLCQRRGRRPGLALGYATGAVGSLGVVVAAAAGSVPLVFVSLVVYGAGTATNLLARYAGADLASPARRGRAVSSVLFATTLGAVVGPNLVDVTGDLAHAWGVPRLAGPFLLATVAFGAAAVALGTLLRPDPLLLARTMAAAGGPGRPAPPPPGPGGETRAGRAPSRALVAGTAVMVLTQLVMIAIMTMTPVHMTAHGHGTQAAGLVIALHVGAMFLPSPLTGRLVDRFGPPRIAVASGLTLLAAGALAALAPPHSVAALAAALVLLGLGWNFGLVSGTTIVTEAAPPETRASTQGMVDVGVAIAGSTGGMASGVVVASGSYAVLAAGGGVLALLLVPPLALAAARPRAVPAEDAMGGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNP5</accession>
    <name>A0A2G1XNP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem reaction center subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04505</name>
        <name evidence="3" type="ORF">CYQ11_01765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52840">
        <property type="protein sequence ID" value="PHQ52840"/>
        <property type="gene ID" value="BLA24_04505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11789">
        <property type="protein sequence ID" value="PPT11789"/>
        <property type="gene ID" value="CYQ11_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="199" mass="20630" checksum="867C1E27544408CF" modified="2018-01-31" version="1">MNALVLATELAKRPVVTLGGEAVAQIKDTVFDSPAGRIAGFTLSGRGLLAGPLKQSLPWSSVHALGRQAVMIPGREALAAAGVVVASGEAAQGDVLGVRVVTDAGAEAGTVLDVVVERGGRMAGFRIAAAEPLDPRRRSVFVPREEVLAVSGQALVIPAAPRHLVADELPSFTTQVEMYLARQAAPRPGAVREGGERTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNU8</accession>
    <name>A0A2G1XNU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04875</name>
        <name evidence="3" type="ORF">CYQ11_28655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52896">
        <property type="protein sequence ID" value="PHQ52896"/>
        <property type="gene ID" value="BLA24_04875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11444">
        <property type="protein sequence ID" value="PPT11444"/>
        <property type="gene ID" value="CYQ11_28655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="344" mass="36317" checksum="412CC25C5B5B9098" modified="2018-01-31" version="1">MAEDNESGAWRTFRHSPFFPATVLVLIVAAAAGLFAGSYTYAMANPTPHSIPTAVTGVSAPEVKRAEFVQGMEKALGASLRLRHYGSYDAARTAVDEQKVYAILRERPGGAELDVSGASGATVAQLLSETAPQVGGRIGVPVTVKDVNPLQRGDPRGLALFYISLAAVIVGFVGAIQLSVHASKLNPGERIAFTVAYSALGGFTIAAIVDWGLGALRLPFAESWLILALTMFTSGMVFSMFNVLIGRWAMLPTWGLMVLLGNPSSGGAVSWPLLPSPLGTIGRWLPPGASVNAQHTAVYFGGHQHVFPFAVLAAWAAVSCAVFWTWRHRHPGGRELRTAAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPE6</accession>
    <name>A0A2G1XPE6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BACON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53117">
        <property type="protein sequence ID" value="PHQ53117"/>
        <property type="gene ID" value="BLA24_03340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACON" evidence="2">
        <location>
            <begin position="517"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="627" mass="64573" checksum="98302F6CA6F8754E" modified="2018-01-31" version="1">MMTRRPEPPTHATGAHRAPSRAPRAVQPPVVQHVEHPEHVEHADTTASVQSAEPGEPAGDTVASHPVPNDPLDDTLVEGLARDAPQPHGSRATPPAADSAPSPYEPWLDGLFTYCLSVLREHESAVAALGGVLALAERRADRAPAAEEAHRVWLYALARWECLRRLAEPGPRPAPGAAGDARARAELALLAWPEAAGTTAEQREALELAVRHGLAPHEVAAVLRLDHNAARTLLSTAACEVERTRTALAVVESGRCPVVARFTGETEVLLGAALRRELVRHVDECADCRRTAERANAGEPWPGTAASSAPLPVLEAPRPGVRAALHRALGARPQRRRQAARAMPRFDRGGFPLAPKDRAARRGRLRSRAVTTTVVATVIAAPVLALWAAYRGGPSGDEQGAAPVSATETDSLGGSPHEGAYDGSYGGPYDGTYGGGPFDDGHGGAGRARGAGASASVGHRFPDVSVAVVGPDGKPVSGPPAPAATPPAAAVGAPLAPAARGPVLGPGRLTVEAQPSGTVTLVTLTASGGEPVSWSMSADAPWLRLSQPGGVLRPGQSVTITVEVDHAREPAGPWRARVAVAPGGAAVTIEGCGAPPEPTPTVPAHPSAPPPATSPAPVPAPEQTHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPK4</accession>
    <name>A0A2G1XPK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000052">
        <property type="protein sequence ID" value="PHQ53079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53079">
        <property type="protein sequence ID" value="PHQ53079"/>
        <property type="gene ID" value="BLA24_03740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="79" mass="9181" checksum="A2CF517265B93BDF" modified="2018-01-31" version="1">MRISRRSVRNRLEWMWRDHPFTRARSWPSRSPWPWSPPPGSCWAACSRASPRWSSAATRCSTRRCSPPPSPGRRSPTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPZ4</accession>
    <name>A0A2G1XPZ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uroporphyrinogen-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cobA</name>
        <name evidence="16" type="ORF">BLA24_03080</name>
        <name evidence="17" type="ORF">CYQ11_05380</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53302">
        <property type="protein sequence ID" value="PHQ53302"/>
        <property type="gene ID" value="BLA24_03080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12399">
        <property type="protein sequence ID" value="PPT12399"/>
        <property type="gene ID" value="CYQ11_05380"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="15">
        <location>
            <begin position="169"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ53302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="409" mass="42749" checksum="CE72BC0E44C01E5A" modified="2018-01-31" version="1">MAEPAHVAAYPVGLRLAGRRVVVLGAGQVAQRRLPALLAAKADVLLVSPSATPSVEAMADAGELRWERRRYRDGDLDGAWYALISTDDPAANEAASAEAEARRVWAVRSDDAEAASAWTPATGRAAGVTVAVLTGRDPRRSAAVRDAVVEGLRDGSLAAPHHRTAAKGVALVGGGPGDPDLITVRGRRLLAEADVVIADRLGPRDLLDELPPHVEVIDAAKIPYGRFMAQEAINNALIQHAKAGKAVVRLKGGDPFVFGRGMEELQALAEHGIPCTVVPGISSTISVPAAAGIPVTHRGVAHEFTVVSGHVAPDDPRSLVDWEAVARLRGTLVLLMSVEKIGAIAETLIGHGRSADTPVAVVQEGTTAAQRRVDATLATVGERVRAEDIRPPAVIVIGDVVTVGPDTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ64</accession>
    <name>A0A2G1XQ64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01485</name>
        <name evidence="3" type="ORF">BLA24_28265</name>
        <name evidence="5" type="ORF">CYQ11_07205</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000024">
        <property type="protein sequence ID" value="PHQ53385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48618">
        <property type="protein sequence ID" value="PHQ48618"/>
        <property type="gene ID" value="BLA24_28265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53385">
        <property type="protein sequence ID" value="PHQ53385"/>
        <property type="gene ID" value="BLA24_01485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12702">
        <property type="protein sequence ID" value="PPT12702"/>
        <property type="gene ID" value="CYQ11_07205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045924">
        <property type="entry name" value="DUF6343"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19870">
        <property type="entry name" value="DUF6343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="90" mass="9849" checksum="8FAB0510E1D6AFD5" modified="2018-01-31" version="1">MRTGNEPMTARSPLRLRCGLAAFGLVWTIAGTVLFALAGQPGWAIACGVLVAVTVVDLTLIIRHIRQGPHYQPGRDVPPYEAVREERRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ74</accession>
    <name>A0A2G1XQ74_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000021">
        <property type="protein sequence ID" value="PHQ53395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53395">
        <property type="protein sequence ID" value="PHQ53395"/>
        <property type="gene ID" value="BLA24_01380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013948259" evidence="2">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="115" mass="11488" checksum="E6C9E0C0A717EEB1" modified="2018-01-31" version="1" fragment="single">ATVSNRLSRSRRANPSRKPSVAAVSSHRTRASSSSSCAAQRGASVPRVPAGLGGDHVDGEAFLAGGEVPAYEPDDVGRLPAALPAAPHRPSAQRRTARPTASQPAGAAASADAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ89</accession>
    <name>A0A2G1XQ89_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01475</name>
        <name evidence="1" type="ORF">BLA24_28255</name>
        <name evidence="3" type="ORF">CYQ11_07215</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000024">
        <property type="protein sequence ID" value="PHQ53383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48616">
        <property type="protein sequence ID" value="PHQ48616"/>
        <property type="gene ID" value="BLA24_28255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53383">
        <property type="protein sequence ID" value="PHQ53383"/>
        <property type="gene ID" value="BLA24_01475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12704">
        <property type="protein sequence ID" value="PPT12704"/>
        <property type="gene ID" value="CYQ11_07215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="245" mass="25995" checksum="8254B883071828FD" modified="2018-01-31" version="1">MTQFVDVREPTACLKPPGEPEDFLDPLESINAVCDVLTPGSWLLKLAELMLPRDPVAWAQEQLAGDWKAYAKCSETWRRAGQACDAVARNIDAGVKDIDATWDGNAAEAALRYFDALRGDLEEFRTSLQAMGDEYLAVAQAVSAAGQAIGECIGAITDALVTGAIAAAASTALGWTGWAAAMGYALGAQEARVIIKEWERMTRLINAAQLAMNAGYAAMGRVGGEAMAKLNTFPLPGASYDHPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ94</accession>
    <name>A0A2G1XQ94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01135</name>
        <name evidence="2" type="ORF">BLA24_22945</name>
        <name evidence="4" type="ORF">CYQ11_23130</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000013">
        <property type="protein sequence ID" value="PHQ53415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48966">
        <property type="protein sequence ID" value="PHQ48966"/>
        <property type="gene ID" value="BLA24_22945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53415">
        <property type="protein sequence ID" value="PHQ53415"/>
        <property type="gene ID" value="BLA24_01135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15389">
        <property type="protein sequence ID" value="PPT15389"/>
        <property type="gene ID" value="CYQ11_23130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022534">
        <property type="entry name" value="DUF2563"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10817">
        <property type="entry name" value="DUF2563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="16778" checksum="B5A61768B9DD89D6" modified="2018-01-31" version="1">MGSGTPDLNAPSESLEDFKRRVDRLLEKLDGSAASHTKIADQKVKGGAYGNFAEAQALASAYDTVHAQLEVLSRALGDRLSAMGIAVSAADKGYRHVDGEQARQLAAIQKRGDEYWEQQKKWGDNLTKQPKTEHQDKGGGAEHQDKGGPSSGGTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQN1</accession>
    <name>A0A2G1XQN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00900</name>
        <name evidence="3" type="ORF">CYQ11_07910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53520">
        <property type="protein sequence ID" value="PHQ53520"/>
        <property type="gene ID" value="BLA24_00900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12825">
        <property type="protein sequence ID" value="PPT12825"/>
        <property type="gene ID" value="CYQ11_07910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="9111" checksum="FBF14FBE05C591A7" modified="2018-01-31" version="1">MYVCSCFGITEQQVREHADKGACTPRKIASACKAGTDCGSCVRRIQALLGRGACPRRELADQGEGDVLAAEVTLMAPSASAPDAARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X996</accession>
    <name>A0A2G1X996_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_30255</name>
        <name evidence="8" type="ORF">CYQ11_23350</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47797">
        <property type="protein sequence ID" value="PHQ47797"/>
        <property type="gene ID" value="BLA24_30255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15422">
        <property type="protein sequence ID" value="PPT15422"/>
        <property type="gene ID" value="CYQ11_23350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ47797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="374" mass="40876" checksum="08572A00784FF4EA" modified="2018-01-31" version="1">MPRWLPRAVVTTLALFACFQLAAWAFHQLIGLFINILIAFFLALAVEPAVDRLSARGMRRGLATGLVFLGVAAVFVGFFTLMGSVLAGQIQTMVQEFPSYLDSVINWVNRSFHTRFSRVQVQESVLHSDWLQRYVRNSASGVLDVSATVIGGLFQALTVALFSFYFAADGPRLRRALCSVLPPQRQADVLRAWELAVSKTGGYIYSRALMALFSGIAHYVVLEILGVPYAPALAVWVGLVSQFIPTIGTYLAGALPVLIAFTVNPWYAVWVLVFVVVYQQFENYLLQPRITAKTVDIHPAVAFGSVVAGAALLGAVGALIAIPVTATLQAFLGVYVKRYEVADDADEPRAGRRGRGGRDRPSLLSRLIKALRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9C1</accession>
    <name>A0A2G1X9C1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_30360</name>
        <name evidence="6" type="ORF">CYQ11_23455</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47818">
        <property type="protein sequence ID" value="PHQ47818"/>
        <property type="gene ID" value="BLA24_30360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15443">
        <property type="protein sequence ID" value="PPT15443"/>
        <property type="gene ID" value="CYQ11_23455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="631"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ47818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="712" mass="76890" checksum="EB69EA3E6EB8C104" modified="2018-01-31" version="1">MSAEATNTGAPGRRRGRRIDLRRLGRAALAGSGARGRLPDAIDHVAKVHRAHHPGADLDILRRAYVLAESSHRGQTRKSGEPFITHPLAVTLILAELGAETTTLTASLLHDTVEDTEVTLDQVGEQFGEEVRYLVDGVTKLEKVDYGAAAEPETFRKMLVATGNDVRVMSIKLADRLHNMRTLGVMRPEKQARIAKVTRDVLIPLAERLGVQALKTELEDLVFAILHPEEYARTRDFVLAHADRPTPLEATAARVRAVLREAGIAAEVIVRRRHFVSVHRVRLKRGELTGSDLGRLLVLVAEDADCYAVLGELHTCFTPFISEFKDFIAVPKFNLYQSLHTAVAGEDGGAAEVLIRTHQMHRVAEAGVIALGNPYAAPEVPDATDGERADPTRPGWLSRLLEWQRATPDPDTFWTSLRDELAQDREITVFRAGGGTLGLPAGSSCVDAAYALHGDGAHHCFGARVNGRLATLSTVLRDGDTLQLLMSADPASGPSPDWLDHVRTPAARIAIRRWLATHPASDPPPPAPPAQPAPGPLRAAPHPPAPAGPTRRTVAVVAEGSGHAGAGLRLAGCCTPVPPDEVTGFTVRGGTVTVHRSHCPAVERMVTSGRRPVAVHWRVTDGADAVDYRVTLRAESFSRPHLLADLTEVIAAEGAAVISAAVEPPHEQRVRHTYTLQLSDAGRLPELMRAMRRVPGVYDVERAGRQAAPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9F3</accession>
    <name>A0A2G1X9F3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPr family phosphocarrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30585</name>
        <name evidence="3" type="ORF">CYQ11_23680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47857">
        <property type="protein sequence ID" value="PHQ47857"/>
        <property type="gene ID" value="BLA24_30585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15482">
        <property type="protein sequence ID" value="PPT15482"/>
        <property type="gene ID" value="CYQ11_23680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="9417" checksum="1AE1491491BE8E7B" modified="2018-01-31" version="1">MVERRVNVGWAEGLHARPASIFVRAATAAGVPVTIAKADGTPVNAASMLAVLGLGAQGGEEIVLATEAEGAEAALDRLAKLVAEGLEELPETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9I1</accession>
    <name>A0A2G1X9I1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_30740</name>
        <name evidence="8" type="ORF">CYQ11_23835</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47887">
        <property type="protein sequence ID" value="PHQ47887"/>
        <property type="gene ID" value="BLA24_30740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15512">
        <property type="protein sequence ID" value="PPT15512"/>
        <property type="gene ID" value="CYQ11_23835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ47887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="226" mass="24226" checksum="BDA371E314F53D3B" modified="2018-01-31" version="1">MRVAIAGAGAVGRSIAGELLENGHEVLLIDKAPSAISVERVPLAEWLLADACEITSLDEAALQRCNVVIAATGDDKVNLVVSLLAKTEYGVPRVVARVNNPKNEWLFNEAWGVDVAVSTPRLMSALVEEAVSVGDLVRLLRFSQGDANLVELTLPPEAALAGTRVGDVDWPEDTSLVTIIRGNRVLTPNREDALEAGDELLFVASPAREEQLEDLLSVRREDAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9L3</accession>
    <name>A0A2G1X9L3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30970</name>
        <name evidence="2" type="ORF">CYQ11_24070</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47924">
        <property type="protein sequence ID" value="PHQ47924"/>
        <property type="gene ID" value="BLA24_30970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15549">
        <property type="protein sequence ID" value="PPT15549"/>
        <property type="gene ID" value="CYQ11_24070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="33569" checksum="8DD892AD9B436A16" modified="2018-01-31" version="1">MTELARAVLAVVRADRAGTVLVSREPITGLQIAAGHPIGKWHGDPRNRDAWRRLLQMQSKWPHRIVFPEGQDFYDVEYRHQGEPVEGLGAAHLMDGLGVSLPVEPCWDADHVTLEREQLLEGEDGTYRSDISEVRVRHLSSSAHYEVHGPWVRDGAEAARKGGLAAVRHGGHLWERRAGLFPRLQFLPEVEAHLRQLPPVWVQPVRDRLAELEEAVSAWDPDTRPIAPQWRSDVRTEFESRRRLCWFTDLDGEQRLFDWHCDFLPSPGRMHFRLLHEQRTLRIAYVGRKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Y8</accession>
    <name>A0A2G1X9Y8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rsgA</name>
        <name evidence="6" type="ORF">BLA24_31800</name>
        <name evidence="7" type="ORF">CYQ11_24855</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48038">
        <property type="protein sequence ID" value="PHQ48038"/>
        <property type="gene ID" value="BLA24_31800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15664">
        <property type="protein sequence ID" value="PPT15664"/>
        <property type="gene ID" value="CYQ11_24855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="106"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="114"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="207"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="38284" checksum="83F6CEA773F98A0D" modified="2018-01-31" version="1">MPHHGSTHPLTGYGWDAEFADSFAVHAADGLVPGRIIRVDRGRCDLVVPDGDGVRTVLADTALVTTGDPLRIMCTGDWAAVDLAAGHVRALLPRRTAFVRSTSSKRSEGQILAANVDHAVIAVSLAVELDLGRIERFLALAWESGATPLVVLSKADLVPDPAVLAHLVADTEAAAPGAQVLAVSAETGEGVDALAAVLAGATSVLLGQSGAGKSTLANALLGTETQTVQAIRDRDGKGRHTTTTRNLLALPGGGVLIDTPGLRGVGLWDAEDGVARTFSEIDELAAECRFHDCGHASEPGCAVLAAVEAGELPERRLASYRKLLRENAHIAARTDARLRAEMRREWKVIQAAGRRMNAEKRGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA63</accession>
    <name>A0A2G1XA63_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32290</name>
        <name evidence="5" type="ORF">CYQ11_25345</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48118">
        <property type="protein sequence ID" value="PHQ48118"/>
        <property type="gene ID" value="BLA24_32290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15743">
        <property type="protein sequence ID" value="PPT15743"/>
        <property type="gene ID" value="CYQ11_25345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758817" evidence="2">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="3">
        <location>
            <begin position="141"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="32084" checksum="0902FBE625AF3E86" modified="2018-01-31" version="1">MTVLLLLPLLLPFAVPALATHAERRLAPVTALWVLTLTAVALAGGSLTALGALVLTGLLKLPVLAAYGELIHPLRTPWDAVAVPFAAASVGLLAVGAWTLTRSALRQAKALRAAHAEAGRRPAAGDLCVIDSPYPDAYALPGWPARVVVTTAMIRSLGPAEREVLFAHERAHNAGRHHYFLAVAELAAHCHPALRTVRASIRFAAERAADEAAAAAVGDRRLTARAIARAALAAGAHRPGRPVVTPAATTGPVPRRVAALLAGPRHRAHRAAPWIAVLLALCAATAAGASVASLVAFHHDVEVAQGEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA73</accession>
    <name>A0A2G1XA73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-D-S-L family lipolytic protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32380</name>
        <name evidence="4" type="ORF">CYQ11_25430</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48130">
        <property type="protein sequence ID" value="PHQ48130"/>
        <property type="gene ID" value="BLA24_32380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15756">
        <property type="protein sequence ID" value="PPT15756"/>
        <property type="gene ID" value="CYQ11_25430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304765" evidence="1">
        <location>
            <begin position="42"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="406"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="610" mass="64695" checksum="2345F0AE642DC711" modified="2018-01-31" version="1">MLRITKLGTRHGRRHRRWTVSGALAAGAACALTLTGTPAQADTDAPRREPLPLERLFDNRAVSDDDRPRAADFDGAGGSLSAQDLVRAGWTAGRALDVDASRLQLPRWAPGRPDNVRADGQAVRLGGRGEALSFLVAGTGGDASGTGVVRYRDGSASTYTLTAPDWRRGPLTTKAVGLPHRNTPDGQRSETTRLYAVTVPVARGRDVTSVVLPKAPGRDVALHVFALSLRAPSNGWTGSWAASTSGYAAVGPWTDRTLRLIVHSSAGGPRTRIRLENTFAPSTLRIGHASVAVQRGDGATAAGRPVPLAFGGRAGTEIPAGAQRFSDPVDFSVPPDTNLLVSIHLPGTVRALPVHSYSNQVSYMSADGAGDRTAERGAGAYSQRLGNWPLLTGVDVAGGPGSVVTLGDSITDGEASAPGTNGRWPDLLARRLRAQHTVPRFGVLNHGISGNRVATDRYQGEGTSTVMSGVSAGHRLERDVLSQTSARTVIVFEGVNDIRAGTKADEVVAVLRSIAERAHQRGIRVVAATIAPCGGFYDCTKEADDARVAINRHIRTARGLYDAVFDFDAAIRDPEHPERMLPRYDAGDHLHPNDAGMRVFSETVDLRKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAA4</accession>
    <name>A0A2G1XAA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TIGR03842 family LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32475</name>
        <name evidence="3" type="ORF">CYQ11_25525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48145">
        <property type="protein sequence ID" value="PHQ48145"/>
        <property type="gene ID" value="BLA24_32475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15771">
        <property type="protein sequence ID" value="PPT15771"/>
        <property type="gene ID" value="CYQ11_25525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022315">
        <property type="entry name" value="F420_OxRdatse_CPS4043_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03842">
        <property type="entry name" value="F420_CPS_4043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="332" mass="36663" checksum="C65A4B7A00EF60F1" modified="2018-01-31" version="1">MDFGLVLQTDPPATAVVDLMRRAERCGFRYGWTFDSAVLWQEPFVIYSRVLEHTERLVVGPMVTNPSTRSPEVTASTFATLNDMYGNRTVCGIGRGDSAMRVAGRKPNTLATLSEAMRVIRDLAEGRETDIDGTLMRLPWVRDGRLPVWMAAYGPKALALAGREADGFILQLADPFLTEWMIKAVRAAAADAGRDPSSVTICVAAPAYVGEDLAHAREQCRWFGGMVGNHVADLVSRYGEHSGVVPEALTAYITRRQGYDYSHHGRAGNPSTDFVPDEIVDRFCLLGPVEAHRERLEHLRELGVDQFAVYAMHDAKEATIDAYGEHLVPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAA5</accession>
    <name>A0A2G1XAA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32175</name>
        <name evidence="4" type="ORF">CYQ11_25230</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48099">
        <property type="protein sequence ID" value="PHQ48099"/>
        <property type="gene ID" value="BLA24_32175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15724">
        <property type="protein sequence ID" value="PPT15724"/>
        <property type="gene ID" value="CYQ11_25230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758821" evidence="1">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="55"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="336" mass="35585" checksum="FA16C5DC03391C0C" modified="2018-01-31" version="1">MARVRTGVRAVSAVLAAVLGATLAGCSSTGGKRAEERAAKAAQGRAAVDTPRWTFAMVTHSGDGDTFWDIVQSGAKQAAAKDNIKFLYAHDVEGNKQAQNVQAMIDQKVDGLIVTLAKPDAMKDVVAKAAKAGIPVITVNSGSDKSKDFGALTHIGQDEVIAGEAVGEQLNARGKKKAVCVLHEQGNVGHEQRCEGVKKSFKGDLENLYVEGTNMPNVQSSIEAKLQSDKDIDAVVTLGAPFAPTAVKAAQQAGSKAEVDTFDLNAKVADALQKGTLGFAVDQDPYLQGYEAVDLLWLYRYNRDMLGGGRPVLTGPQIVTKDDAKTLAEYTKRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC8</accession>
    <name>A0A2G1XAC8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR01458 family HAD-type hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32645</name>
        <name evidence="2" type="ORF">CYQ11_25695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48173">
        <property type="protein sequence ID" value="PHQ48173"/>
        <property type="gene ID" value="BLA24_32645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15799">
        <property type="protein sequence ID" value="PPT15799"/>
        <property type="gene ID" value="CYQ11_25695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="28125" checksum="E26A55418982AAC4" modified="2018-01-31" version="1">MNFHVRALLIDINGTVFDHGDAIDGAPKAINRLRDGGYALRFLTNTESKTVEVTLESLRACGLHVEREELFTPVVAAQTLLACSPGARVLPLMSEELRKAFPPSGRTVGAPAATPTHVIVGDCQAVLDYPLLNRAFRAVRAGAELIALQRGALYRTPQGEEFLDTGAIVAALEYGTGRSARLLGKPSSEYFGLAATSTGFSPQETAVIGDDATTDGTGGRSIGAMTVQVRTGKYADQVAAGVAGGASHTVASVAEVPDLLRRLEHATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAR4</accession>
    <accession>A0A346M2J0</accession>
    <name>A0A2G1XAR4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BcmG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bcmG</name>
        <name evidence="6" type="ORF">BLA24_33470</name>
        <name evidence="7" type="ORF">CYQ11_26520</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <title>Biosynthesis of biocyclomycin.</title>
            <authorList>
                <person name="Meng S."/>
                <person name="Pan H.-X."/>
                <person name="Tang G.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MG018995">
        <property type="protein sequence ID" value="AXQ04978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48313">
        <property type="protein sequence ID" value="PHQ48313"/>
        <property type="gene ID" value="BLA24_33470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15944">
        <property type="protein sequence ID" value="PPT15944"/>
        <property type="gene ID" value="CYQ11_26520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="151"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AXQ04978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="33855" checksum="E4749DE79712999A" modified="2018-01-31" version="1">MSTAQGYGWQTAALRGGELVFSTPGGIEQALRDGFFHVEQPEGLDLTAGDRFARGFYLPGEPDSTDPFRGFQHWTSERLGPRQGYYCRDDDQTEQFFLESAHWDSVYPQALARQAEAMRSLALDVLRAVLAHLELPPELWDEATGRCLSARGTYNLTFNHFRPEVPRRGLNVHKDSGWVTVLRSTDPGLEVERDGAWHPIDPRPGTFIVNFGCAIEILTRDTRTPVAAVAHRVVQQPRTDERKPDRFSYALFVDSSLDEDICPGLFRYEPGTGLRLETNFGTFLDTILHNTYQKDTAGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX8</accession>
    <name>A0A2G1XAX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hopanoid biosynthesis associated radical SAM protein HpnH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hpnH</name>
        <name evidence="6" type="ORF">BLA24_33075</name>
        <name evidence="7" type="ORF">CYQ11_26125</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48388">
        <property type="protein sequence ID" value="PHQ48388"/>
        <property type="gene ID" value="BLA24_33075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15876">
        <property type="protein sequence ID" value="PPT15876"/>
        <property type="gene ID" value="CYQ11_26125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="37"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="353" mass="40113" checksum="91AAD92901336DEC" modified="2018-01-31" version="1">MAPFFAAPQEVSQMAMPLRQTIRVGTYLFEQKLRRREKFPLIVELEPLYACNLKCEGCGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVARRKYVFLCTNALLMRKKMEKFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGFRVTTNSTFFNTDTAQTVVEVLNYLNDELRVDEMMISPAYAYEKAPDQEHFLGVEQTRELFKKAFSGGNRKRWRLNHSPLFLDFLEGKADFPCTAWAIPNYSLFGWQRPCYLMSDGYVPTYRQLIEETDWDKYGRGKDPRCANCMAHCGYEPTAVLATMGSLKESLRAARETVSGNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB28</accession>
    <name>A0A2G1XB28_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_29120</name>
        <name evidence="9" type="ORF">CYQ11_06355</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48438">
        <property type="protein sequence ID" value="PHQ48438"/>
        <property type="gene ID" value="BLA24_29120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12566">
        <property type="protein sequence ID" value="PPT12566"/>
        <property type="gene ID" value="CYQ11_06355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="38"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="549" mass="56105" checksum="9D32E585B691EBF2" modified="2018-01-31" version="1">MSGTTTAGPRRPVGVPRQRPRPRRAEGRAAGGVSRWTVLVVLCVSLLLVAVDATVLHVAVPAVSEDLRPGAIQLLWIVDVYPLVCASLLILFGTLGDRVGRRRVLLLGYGLFGLASALAALATVPEVLIAARALLGVGGAMIMPATLSILRQVFPDRRERAVAIGVWSAVAAVGAALGPLVGGLLLQHFWWGSVFLINIPLMLVTLPVGRLLLPESTGDRNGPWDVLGALMAAFGLFGLVYGVKRVGSAEPLSLSTVVPAALGAALLVLFVRRQRRRRHPLVDLAMVARPAFGTSVGCIVLALLALVGLELIAAQYLQLVLGLTPLETGLRLLPLTLAAMAAGLSGSRVLQRFGPRAMVCGGFVLTAMAVLSLTVMGHDDRPVALTLGFLLLGFGLETTLFGAYESMLSEAPAESAGGAAAIGETSYQLGAGIGIALLGSVMNAAYAPAVEAVPGVPSAAGRAASHSLGEAYDVADRLGGPAGAALRAAARDAFVHGLHTALAVSAGLLLLGALAALRLPRGLECAAPEVAPGAVPAGRGPGPDEAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB51</accession>
    <name>A0A2G1XB51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1684 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29140</name>
        <name evidence="2" type="ORF">CYQ11_06335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48442">
        <property type="protein sequence ID" value="PHQ48442"/>
        <property type="gene ID" value="BLA24_29140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12562">
        <property type="protein sequence ID" value="PPT12562"/>
        <property type="gene ID" value="CYQ11_06335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="264" mass="28920" checksum="5ECC4E01468B2DB0" modified="2018-01-31" version="1">MSTDDARRRWEVWREERAEAVSAPYGPLALTGTHWLAEAPEGRIPAIPGRWTPDPGAGSVLLSAAAEDGLTLDGRPLEGRARLRPDGGPAVARVAHGERKLPVLRREGLWAVRVFDPGSPRRRAFAGIDVFDHAVRWALPGRFRPYERERAVLVAHADGRERPLRLSGELVFALGGEEYTLQAGTEADGSLWAVFSDGTSGTAGYRFRFLRLPAPESGRPVTVDFNRAVLPPCAFADHFICPFPPPGNRLPFPVPAGERNPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBA2</accession>
    <name>A0A2G1XBA2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">metH</name>
        <name evidence="30" type="ORF">BLA24_29575</name>
        <name evidence="31" type="ORF">CYQ11_05900</name>
    </gene>
    <organism evidence="30 32">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="30 32" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 32">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="31 33" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 33">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48508">
        <property type="protein sequence ID" value="PHQ48508"/>
        <property type="gene ID" value="BLA24_29575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12493">
        <property type="protein sequence ID" value="PPT12493"/>
        <property type="gene ID" value="CYQ11_05900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="14"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="348"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="29">
        <location>
            <begin position="640"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="28">
        <location>
            <begin position="733"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="27">
        <location>
            <begin position="880"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="743"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1164"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="930"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PHQ48508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="PPT12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1168" mass="127439" checksum="5453DA4090D5BF00" modified="2018-01-31" version="1">MASHTPSTVHSARSAQLREALATRVVVADGAMGTMLQAQDPSLEDFQQLEGCNEILNVTRPDIVRSVHEAYFAVGVDCVETNTFGANLAALGEYEISDRIFELSEAGARVAREVADEFTAGDGRTRWVLGSVGPGTKLPTLGHAAYPVLRDAYQRNVEGLVAGGADAVLIETTQDLLQTKASVVGARRAMEAAGVDLPLLVQVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPAEMSEHLRYLSRHARTRVSAMPNAGLPVLGKDGAHYPLSPAELADAHETFIREYGLSLVGGCCGTTPEHLRQVVERVRGLAPAGRSPRPEPGASSLYQTVPFRQDTSYLAIGERTNANGSKKFREAMLDGRWDDCVEMAREQIREGAHLLDLCVDYVGRDGVADMAEIAGRFATASTLPLVLDSTEPAVIQAGLEKLGGRAVINSVNYEDGDGPDSRFARITRLAVEHGAALIALTIDEDGQARTPEHKVAVAERLIADLTGNWGVRECDIIVDCLTFTIATGQEESRRDGIATIEAIRELKRRHPDVQTTLGLSNISFGLNPAARMVLNSVFLNECVEAGLDSAIVHASKILPIARLEEEQREVALDLIYDRRREGYDPLQRFLELFEGVDTKSMKAGKAEELAALPLEERLRRRIVDGEKNGLEADLDEALTTRPALDIVNDTLLEGMKVVGELFGSGQMQLPFVLQSAEVMKSAVAHLEPHMEKSDAEGKGTIVLATVRGDVHDIGKNLVDIILSNNGYNVVNLGIKQPVSAILEAAEEHRADVIGMSGLLVKSTVIMKENLEELNQRKLAATYPVILGGAALTRAYVEQDLHEIYEGEVRYARDAFEGLRLMDALIAVKRGVPGASLPELKQRRVPKRETAVPEVDEPQGAVRSDVAVDNRVPEPPFWGTRVVKGIPLKDYASWLDEGALFKGQWGLKQARAGGPTYEELVESEGRPRLRGLLEKLHTENLLEAAVVYGYFPCVSKGDDLILLHEDGTERTRFTFPRQRRGRRLCLADYFRPEESGERDVVGLQVVTVGSRIGEATAELFASDSYRDYLELHGLSVQLAEALAEYWHARVRAELGFAGEDPADVEDMFALKYRGARFSLGYGACPDLEDRAKIADLLEPERIGVHLSEEFQLHPEQSTDAIVIHHPEAKYFNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBC9</accession>
    <name>A0A2G1XBC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29615</name>
        <name evidence="4" type="ORF">CYQ11_05860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48515">
        <property type="protein sequence ID" value="PHQ48515"/>
        <property type="gene ID" value="BLA24_29615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12486">
        <property type="protein sequence ID" value="PPT12486"/>
        <property type="gene ID" value="CYQ11_05860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304695" evidence="1">
        <location>
            <begin position="28"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="84"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="531" mass="57918" checksum="1AEBC9E03E875AFC" modified="2018-01-31" version="1">MNRKTLVLPIVAGLLAPVLVACGGSEGAGKDSAIVIGTTDRFEETTDAPAPFDPAAAYDVGAWNVLHSTFQTLLRLPRSGTAPVGDAAEKCTFGDRKNEQFRCTLRSGLKFSNGHALTAEDVKFSIDRARAINYENGPVSLLSNIDKVETPGDLEVVFHLKSPDATFPQKIATPAAAIVDSESYEKDKLGSGFKVVGSGPYTLQTEQKDGHVVKVTLNKNSDYRGSVKVLNDKVEMRFFDDAASMEKALKSGDIDMMNRALLPEQIGRLRGSSGEGVRLLELPGQEISFLAFNTDDSTVKSKAVRQAIAQVVDRAALVRDGYDRTSDPLYSLVPTGIAGHQNSFSNRYGEPSADKARAILKAANVSAPVPITLTYTSDHYGEGTERAFKALQKQLTASGLFDVKIQGVKWADFRPEAAKGKYAVYGMHWFPDFPDPDNFVAPFVGKDNFLRSPYRNTKISNELVPQSRESTQRDAAARYFQQAEDLIADDVPVLPLWQGKQYVAVREKITGAEWALSSASELQPWELSRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBG6</accession>
    <name>A0A2G1XBG6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_29635</name>
        <name evidence="15" type="ORF">CYQ11_05840</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48519">
        <property type="protein sequence ID" value="PHQ48519"/>
        <property type="gene ID" value="BLA24_29635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12482">
        <property type="protein sequence ID" value="PPT12482"/>
        <property type="gene ID" value="CYQ11_05840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="288"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ48519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT12482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="412" mass="43534" checksum="F92E3145AB01FC4C" modified="2018-01-31" version="1">MNDSGQGDTGVGGAGPPAGPQDRKPQRPRESGGGILMGRPFGVPVYVAPSWFLVAALITWVFGGQLDRVLPDLGRLRYLVALFFAVAFYASVLIHELAHTVAALRFKLPVRRIQLQFFGGVSEIEKESETPGREFVLAFVGPLLSLALAGVFYLAMLAVEPGTVPGVLLAGLMISNLLVAAFNLLPGLPLDGGRMLRAVVWKISGKPMTGTIAAAWVGRALAVAVLLGLPLLTHGGIGDGARDFTGVDALTDALLAAILAAIIWTGAGNSLRMARLREHLPELRARNLTRRAVPVQPTTPLSEALRRAGEAGARALVVVDGHGNPTALVREAAIVAVPEHRRPWVEAGSLAQDIKEGMRIPADLTGEDLLDALRTTPATEYLVVEDTGQVYGVLSTADVERAFVAAMARPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH2</accession>
    <name>A0A2G1XBH2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">BLA24_29860</name>
        <name evidence="9" type="ORF">CYQ11_05610</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48555">
        <property type="protein sequence ID" value="PHQ48555"/>
        <property type="gene ID" value="BLA24_29860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12443">
        <property type="protein sequence ID" value="PPT12443"/>
        <property type="gene ID" value="CYQ11_05610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="99"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="24534" checksum="B7761E8EC3C96DF9" modified="2018-01-31" version="1">MAAREGVTWCYRGGPISAEPRINDRIRVPEVRLVGPSGEQVGIVPLAKALELAQEYDLDLVEVAANARPPVCKLMDYGKFKYESAMKAREARKNQAHTVIKEMKLRPKIDPHDYDTKKGHVVRFLKQGDKVKITIMFRGREQSRPELGYRLLQRLAEDVQELGFVESNPKQDGRNMIMVLGPHKKKTEAMAEAREAQAARKAERQGGSSADAAEEPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBI9</accession>
    <name>A0A2G1XBI9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29250</name>
        <name evidence="3" type="ORF">CYQ11_06225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48588">
        <property type="protein sequence ID" value="PHQ48588"/>
        <property type="gene ID" value="BLA24_29250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16374">
        <property type="protein sequence ID" value="PPT16374"/>
        <property type="gene ID" value="CYQ11_06225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045969">
        <property type="entry name" value="DUF5925"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19347">
        <property type="entry name" value="DUF5925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="186"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="373" mass="40312" checksum="5F194169441F666B" modified="2018-01-31" version="1">MCADATAASPRFPSASPSIRLNVDSDSPADVVDALFLGPFSTGEQPYARGHSVERVRSGATLLPPGATVVRSARDDDRSAVLAEGEGWRLLAARWMRGSAEVTVTAVSDELARTVLERAVEGAEDEPEPQPEHVTMGFWYLSPRRGPHRTTRQISAGTWEEVRANYTAPVADAMDRLMKVTPDDIAGRLLLLHGPPGTGKTSALRTLARSWRDWCQVDCVLDPERLLNDVGYLMDIAIGEDDGSERGRWRLLLLEDCDELIRGEARHAAGQALSRLLNLTDGLLGQGRNVLVGVTTNEDLERLHPAVVRPGRCLARIEVGPLTRAEAVGWLGREEGVGRHGATLAELFALRRGTVPASVPEQQGGGADAGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBQ5</accession>
    <name>A0A2G1XBQ5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_28445</name>
        <name evidence="11" type="ORF">CYQ11_07025</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48648">
        <property type="protein sequence ID" value="PHQ48648"/>
        <property type="gene ID" value="BLA24_28445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12673">
        <property type="protein sequence ID" value="PPT12673"/>
        <property type="gene ID" value="CYQ11_07025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="28"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="26499" checksum="C6411DE3FD9A552E" modified="2018-01-31" version="1">MTTGTFTPRPGAAPLPRMIRAQAALETRMLLRNGEQLLLTVVIPTLLLALFSTVDIVDTGEGEAVDFLAPGVLALAVMSTAFTGQAIATGFERRYGVLKRLGASPLPRWGLMTAKTCSVLVTEVLQTVLLTVIAFALGWSPHGNPFAVVLLLVLGTAAFSGLGLLMAGTLKAEATLAAANLVFLLLLVGGGVIVPLTKFPDAAQSVLGLLPISALSGGLRDVLRDGAGMPWADLGILAGWAVLGLGAAARFFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC90</accession>
    <name>A0A2G1XC90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA invertase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_27795</name>
        <name evidence="9" type="ORF">CYQ11_17845</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48867">
        <property type="protein sequence ID" value="PHQ48867"/>
        <property type="gene ID" value="BLA24_27795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14486">
        <property type="protein sequence ID" value="PPT14486"/>
        <property type="gene ID" value="CYQ11_17845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5 6">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="192" mass="20470" checksum="6220DA90E3C5F93B" modified="2018-01-31" version="1">MTTNTGRLIGYARVSTDGQEAQLQLDALAEAGCARIFTDKASGKNTDRPELTAALDYLRPGDTLCVWKLDRFARSLIDLVTMVDGLAERGVGFKVLTGALASIDPNTADGRLMLQVVGAMAEFERSLIRDRTRAGLDAARAQGRTGGRPTVMDADKLAAAKARRAKGESVTAIAKALEVSRATLYRALADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCP3</accession>
    <name>A0A2G1XCP3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_23180</name>
        <name evidence="7" type="ORF">CYQ11_22895</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49006">
        <property type="protein sequence ID" value="PHQ49006"/>
        <property type="gene ID" value="BLA24_23180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15350">
        <property type="protein sequence ID" value="PPT15350"/>
        <property type="gene ID" value="CYQ11_22895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="245" mass="26092" checksum="28852A907290B82B" modified="2018-01-31" version="1">MVAPPDNDVLWARGLHYSYNGSPALTGVSVGVRECEILAVTGPRGAGKTTLLKCLSGQLLADPGEVWFNSAPVHTLSRSARERLRRERFGWIDTEPHLVPELTGWENAALPLLARGIGHRAAKRTAGEWLERLDVGDCARKRPAALTQAQRQRVAIARALAGEPTVVFADEPTAPLHTADRAQVLRTLTTAARSHQITVVLATLDEENAALADRTVTLVDGRRGGAIPAPEAPGGEGRAACSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT5</accession>
    <name>A0A2G1XCT5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">BLA24_23570</name>
        <name evidence="13" type="ORF">CYQ11_22500</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49067">
        <property type="protein sequence ID" value="PHQ49067"/>
        <property type="gene ID" value="BLA24_23570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15287">
        <property type="protein sequence ID" value="PPT15287"/>
        <property type="gene ID" value="CYQ11_22500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="6"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="341"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="491" mass="54382" checksum="89888A07A902E853" modified="2018-01-31" version="1">MASAPVRVRFCPSPTGNPHVGLVRTALFNWAFARHHGGTFVFRIEDTDAARDSEESYEQLLQAMRWLGFDWNEGPEVGGPHAPYRQSQRMDLYKDVAAKLLDAGHAYHCYCTTEELDARREAARAAGKPSGYDGTCREVTEEQKAQYEREGREPIVRFRMPDEPITFTDLVRGELTFTPENVPDFGIVRANGAPLYTLVNPVDDALMEITHVLRGEDLLSSTPRQIALYRALAQIGVGNGTTPSFGHLPYVMGEGNKKLSKRDPQASLNLYRERGFLPEGLLNYLSLLGWSLSADQDIFTMDEMVAAFDIKDVNANPARFDLKKCEAINADHIRRLDPKAFADACEPWLKAPHAPWAPEKFDRAAWEAIAPHAQTRLTVLSDITANVDFLFLDEPAWDETSWQKAMKEGSDALLRTARTALAEAEWNADALKAAVVAAGEEHGLKLGKAQAPVRVAVTGRTVGLPLFESLEILGRERTLARVDAALAKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD09</accession>
    <name>A0A2G1XD09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23975</name>
        <name evidence="3" type="ORF">CYQ11_22095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49134">
        <property type="protein sequence ID" value="PHQ49134"/>
        <property type="gene ID" value="BLA24_23975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15217">
        <property type="protein sequence ID" value="PPT15217"/>
        <property type="gene ID" value="CYQ11_22095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="32380" checksum="D1A7C83255E8DB8F" modified="2018-01-31" version="1">MNTPADLGHFLRTRRAALRPEDVGLVAYGRTRRVPGLRREELAQLAGVSVAYYTRLEQGQSHNASDEVLDALARALRLTRDEHAHLRNLARPARAGRLPAVRPATAAPGVRQLVAALAVPAVIVDHRFDVLGWNPLGHALLAGHLDAGSPERPGERPNLQRLFFLDPHARELYPRWEAEARRAASSLRLAAGEHPDDRRLAELVGELTMKSPEFAALWSRHPVRGCASGSKCFHHPVVGAMELSFEMLRLPDTGGQGVLAFSAEAGSADEAALRLLATAAATDGDRAGRASDAIAIGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD26</accession>
    <name>A0A2G1XD26_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gcvT</name>
        <name evidence="10" type="ORF">BLA24_23900</name>
        <name evidence="11" type="ORF">CYQ11_22170</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49122">
        <property type="protein sequence ID" value="PHQ49122"/>
        <property type="gene ID" value="BLA24_23900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15230">
        <property type="protein sequence ID" value="PPT15230"/>
        <property type="gene ID" value="CYQ11_22170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="11"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="289"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="38930" checksum="4BD3480DDB62E6BB" modified="2018-01-31" version="1">MTEAPRRTALDATHRALGATMTDFAGWDMPLRYGSERDEHLAVRTRAGLFDLSHMGEITLTGPGAGRALDHALVGDLSALAVGRARYTMICEAGGGILDDLIVYRLGEQEYMVVANASNAQVVLDALTERAAGFDAVVRDDRENYALIAVQGPASPGILKSVTDADLDGLKYYAGLPGTVAGVSALIARTGYTGEDGFELFVAPSDAEKLWQALTEAGADAGLVPCGLSCRDTLRLEAGMPLYGHELTTATTPFDAGLGRVVKFDKAGDFVGREALTAAAERAASAPPRKLVGLIAAGRRVPRAGYPVVTADGTVVGEVTSGAPSPTLGKPIAIAYVDAAHATAGTEGVCVDIRGTHEPYEVVALPFYKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD39</accession>
    <name>A0A2G1XD39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_24165</name>
        <name evidence="12" type="ORF">CYQ11_21910</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49164">
        <property type="protein sequence ID" value="PHQ49164"/>
        <property type="gene ID" value="BLA24_24165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15186">
        <property type="protein sequence ID" value="PPT15186"/>
        <property type="gene ID" value="CYQ11_21910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304898" evidence="8">
        <location>
            <begin position="38"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="294"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="745"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="844" mass="87799" checksum="075780A1DA1EBAE5" modified="2018-01-31" version="1">MFRTALRNLLAHKTRLMMTALAVLLGTAFVSGTLVFSDSVDSAYRNKMAQNLADVAVSVTSGSAGPDTRDQDRLDSRAVDKIVSLPGVASVRPSVTGTAMVADKHNEPVGNDWGSTGANYAPGKDGKDSRYPLVRGRGPAAEGEIALDAKSARKAGVEVGGTVRLAVDGPVMTKKLVGVVRTGDPRVSAGGSLALFDTATAQKLFGKPGEFSELVVSATPGTDQARLTAQVREALPKTFEARSGKQLAATEAKMIDADTSAIRKTFLVFAGISLFVGVFIIANTFTMLIAQRTREIALLRAVGASRRQVVRSVLIEAGVLGLVASAAGFLLGLGIAVGLRPVLNTTGASLPDGPLVLKPEAALSALGVGVVVTVLAAWLPSRKAAKIAPVEALAAVEQPPAVRSLVVRNALGAVLTGAGIALMLYVTTFKNSSGLQFAMAGSALTLAGVIVLAPLLSRPFVNLCGRLAVRLAGVSGKLARENALRNPRRTAATASALMIGLTLITGLTVAAVSADRGVARMGQQDLTADYKVTSAGLSGLSPEIARTLSGQPGVATAVALRTTGFQSQERPALATAADPRALPSVTDVRAVDGSLTDVRGTTAVAVSDTYAREHGLKVGATLPMAFYDGKQAGPRVVAVYAENDVLSDVLTSTALLDPHLDKVRDEAVLLKAAPGRADSLPEKIKETLGGNPLIKVQSQDDLRRSEAGDIDDVLYLMYGLLGMAVVIAVIGVVNTLAMSVFERTREIGMLRAIGLARREVKRMVRLESVMIAMFGAVLGVGVGVFLAWSGGHLLRSSFPQYTMVVPWARIGLFLLLALAVGVLAAVWPARRAAKLDVLESIGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD40</accession>
    <name>A0A2G1XD40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23895</name>
        <name evidence="3" type="ORF">CYQ11_22175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49121">
        <property type="protein sequence ID" value="PHQ49121"/>
        <property type="gene ID" value="BLA24_23895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15231">
        <property type="protein sequence ID" value="PPT15231"/>
        <property type="gene ID" value="CYQ11_22175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="23558" checksum="7D517096401A1B9E" modified="2018-01-31" version="1">MGTVPTDVEGQAADPWRGPAGPAAPGRVIDLRGERAAPVELRYALGDLLVVSGLPGSGKSTLIRRAVAALDGRGTPIVCVDSQDSRDRFERRTPPWLPYGLYRPLVRLVHFAALRRALRSGASVVVHDCGQRGWVRRWLVRDARRRGAAVHVLLLAVDAGTALAGQAARGRTVPPRVFARHRRAMGALVGRVTAGRVPPGVSSAALLDRASARAVRVIAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDE9</accession>
    <name>A0A2G1XDE9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_24705</name>
        <name evidence="6" type="ORF">CYQ11_21365</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49264">
        <property type="protein sequence ID" value="PHQ49264"/>
        <property type="gene ID" value="BLA24_24705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15084">
        <property type="protein sequence ID" value="PPT15084"/>
        <property type="gene ID" value="CYQ11_21365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="27974" checksum="CFBC50E657329890" modified="2018-01-31" version="1">MNAMVKAEGVHKSYGAAHILKGIDLEVAPREVFCLIGPSGSGKSTFLRCINHLEQINAGRLYVDGELVGYRQQGNKLYELKDSEVARNRRDIGMVFQRFNLFPHMTALANVMEAPVQVKGESKAVARERARKLLDRVGLADKADNYPSQLSGGQQQRVAIARALAMEPKLMLFDEPTSALDPELVGDVLDVMRDLAEEGMTMIVVTHEMGFAREVGDSIVFMDQGVVVESGHPREVLTNPQHDRTKAFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDK1</accession>
    <name>A0A2G1XDK1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_24955</name>
        <name evidence="9" type="ORF">CYQ11_21115</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49308">
        <property type="protein sequence ID" value="PHQ49308"/>
        <property type="gene ID" value="BLA24_24955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15042">
        <property type="protein sequence ID" value="PPT15042"/>
        <property type="gene ID" value="CYQ11_21115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="273" mass="30254" checksum="932679E4DBB49DE5" modified="2018-01-31" version="1">MCGRYAASRRPEDLAGLFGVEKWEPEETLAPDWNVAPTKSVHAVLERPLKDAADRRPVRQLRTLRWGLVPSWARSPEGAAKMINARAETVHEKPSFRRAFESRRCLLPADGYYEWVTGAQERELEEQGRRKRTRKQPYFVTAADGSVMAMAGVYEFWRDPALPPDHPRAWWATCSVITTAAEPGPFAGTDGAGEGGPGSLAEIHPRMPLVLPPERWAAWLDPRTDPGELRSLLAPPPAGLVRAHPVTTAVSDVRNNGPELLEELAAPEEATLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDM7</accession>
    <name>A0A2G1XDM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25125</name>
        <name evidence="3" type="ORF">CYQ11_20945</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49336">
        <property type="protein sequence ID" value="PHQ49336"/>
        <property type="gene ID" value="BLA24_25125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15016">
        <property type="protein sequence ID" value="PPT15016"/>
        <property type="gene ID" value="CYQ11_20945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="204"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="469" mass="50248" checksum="7B744F8FD9CF26B4" modified="2018-01-31" version="1">MSDTPDNVVRAYIDEHRAAFLGDLADWLRIPSVSADPARAGDVRRSADWLAAKLTETGFPVVEVWETGDGAGAPAVFAEWPSGADGAPTVLVYGHHDVQPAAREDGWHTDPFEPTTVDGRLYARGAADDKGQVFFHTLGVRAHLAATGRTAPAVNLKLLIEGEEESGSPNFPALVQARAERLACDMVIVSDTGMWAEDTPTVCTGMRGLTDCQIDLYGPDQDLHSGSFGGAVPNPATEAARLAAALHDDDRRVAIPGFYDGVVELTDAERELFAELPFDEKRWLRAAHSHAALGESGFSTLERVWARPTAEVNGIGGGYQGPGGKTIVPSTAQLKLSFRLVAGQDTDRVQQSVRAWVAARLPEGIRHEVTFWGATRPCLTPLDHPALQSVVRAMGRAFGQKIRFTREGGSGPAADLQDVLGVPVLFLGISVPSDGWHAPNEKVELDLLMKGVETAAHLWGDLAQNAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDS1</accession>
    <name>A0A2G1XDS1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25025</name>
        <name evidence="2" type="ORF">CYQ11_21045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49319">
        <property type="protein sequence ID" value="PHQ49319"/>
        <property type="gene ID" value="BLA24_25025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15032">
        <property type="protein sequence ID" value="PPT15032"/>
        <property type="gene ID" value="CYQ11_21045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="18718" checksum="3327C051730C70A1" modified="2018-01-31" version="1">MAASPLTRAVLEIDEYASTLGWDQPARLFALVDTARLRVQEPGLAAQLGLDDASSTTTSYTPIEQEELPAGAALDEFLGTIAWPDAVVGCALTVERLMLPPSAEGSVPHGMNDKQLAAWVAKHPDRQEVRMTVAVLRDGARESAVRLREKDSPNEVLTGADLVPGLAEALAATFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDX0</accession>
    <name>A0A2G1XDX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25670</name>
        <name evidence="2" type="ORF">CYQ11_20400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49433">
        <property type="protein sequence ID" value="PHQ49433"/>
        <property type="gene ID" value="BLA24_25670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14917">
        <property type="protein sequence ID" value="PPT14917"/>
        <property type="gene ID" value="CYQ11_20400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="59" mass="6866" checksum="1F53AB480EC7D841" modified="2018-01-31" version="1">MTDTGPVLPWLVIRQDENGNRYRVGRYATRMEAERVADRLDAHGHRQLYIVERVGRAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE84</accession>
    <name>A0A2G1XE84_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">BLA24_26140</name>
        <name evidence="15" type="ORF">CYQ11_19500</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49515">
        <property type="protein sequence ID" value="PHQ49515"/>
        <property type="gene ID" value="BLA24_26140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14765">
        <property type="protein sequence ID" value="PPT14765"/>
        <property type="gene ID" value="CYQ11_19500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="32"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ49515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="118" mass="13121" checksum="A8CCAE2F0B239ECB" modified="2018-01-31" version="1">MLLPHQPLQEAAVPSQRISARDQAGPWHSEAVCRRDEAGLFFAPSKEPTAARLSREEAAKRVCARCPVMVACREHALLQPEPYGVWGGLTAAERRVVLARRRRREAELQRTTRIAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE95</accession>
    <name>A0A2G1XE95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26045</name>
        <name evidence="3" type="ORF">CYQ11_20020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49499">
        <property type="protein sequence ID" value="PHQ49499"/>
        <property type="gene ID" value="BLA24_26045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14850">
        <property type="protein sequence ID" value="PPT14850"/>
        <property type="gene ID" value="CYQ11_20020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="31570" checksum="B0BA6C0A51F9BD4C" modified="2018-01-31" version="1">MESASSSAQEARKALGKRLAEIRVAAGLTKRALSEKLEWHESKASRFESAKRAPSERDLREWCSACGAEDQADLLVQTARRIEGMYVQWQQLESGGLKQAQQSALPLWDRTQQFRFYSPWLIPGPVQTASYIKALLTSIRDRRNTIDDVDAAVEVRLEKQKIVYTQRTFAILLEESALYNRMGGPDVMVGQLGYLLSAMALPRVAIGIIPRHIERPLMPVEGFFMFDDHTVKVELVSAHLTVEQEPELRMYAQTFAELYEMAVFGSAAREIITTAIESFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC5</accession>
    <name>A0A2G1XEC5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">BLA24_26380</name>
        <name evidence="12" type="ORF">CYQ11_19260</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49555">
        <property type="protein sequence ID" value="PHQ49555"/>
        <property type="gene ID" value="BLA24_26380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14724">
        <property type="protein sequence ID" value="PPT14724"/>
        <property type="gene ID" value="CYQ11_19260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="246"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="273"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="515"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="606" mass="66711" checksum="362D5E6DF57FB64D" modified="2018-01-31" version="1">MARTSAAPTTPTHHQELISWVDEIAALTQPDQVVWCDGSEAEYERLCEELVAKGTFKKLDPVKRPNSYYAASDPTDVARVEDRTFICSEKEEDAGPTNRWKAPAEMREVFTGDKGLFRGSMRGRTMYVVPFCMGPLGSPLSAIGVEITDSAYVAVSMRTMTRMGQPVLDELGTDGFFVKAVHTLGAPLAKGEADVPWPCNSTKYISHFPEDREIWSYGSGYGGNALLGKKCYALRIASVMARDEGWLAEHMLILKLTPPQGEAKYVAAAFPSACGKTNLAMLEPTVSGWTVETIGDDIAWMRFGEDGRLYAINPEAGFFGVAPGTGENTNANAMKTLWGNAVFTNVALTDDEDVWWEGMTDEQPAHLTDWKGNDWTPASGTPAAHPNARFTVPASQCPIIAPEWEDPKGVPISAILFGGRRASAVPLVTESFTWQHGVFLGANVASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYMGHWVKVGQDKDQSKLPKIYYVNWFRKDADGRFVWPGFGENSRVLKWIVERLDGKAEGVETPIGVLPTKQALDLDGLDLADADLDLLLTVDKDVWREEAALVPEHLNTFGDHTPKELWDEYRALVQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XET5</accession>
    <name>A0A2G1XET5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25565</name>
        <name evidence="4" type="ORF">CYQ11_20505</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49736">
        <property type="protein sequence ID" value="PHQ49736"/>
        <property type="gene ID" value="BLA24_25565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16690">
        <property type="protein sequence ID" value="PPT16690"/>
        <property type="gene ID" value="CYQ11_20505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="21312" checksum="F0BB669D8FD04AF1" modified="2018-01-31" version="1">MTGPTGRRERKKAQTRRSLAEAALQLFLDRGYDQVGVKDVADAADVSVTTLFKHFPSKEALVFDQDDDREAALVAAVRDRAPGQSIPQALCAHVLRTLTKKDDPRFAEFLRMVEDTPALRDYAHRMWMRHEEAVARAVAQEIGAPENDAACAALAHFALETRALAGRYADPRRAVEEVFGLLERGWAGVRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEU8</accession>
    <name>A0A2G1XEU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26545</name>
        <name evidence="3" type="ORF">CYQ11_19090</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49753">
        <property type="protein sequence ID" value="PHQ49753"/>
        <property type="gene ID" value="BLA24_26545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16665">
        <property type="protein sequence ID" value="PPT16665"/>
        <property type="gene ID" value="CYQ11_19090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="490" mass="52185" checksum="02FA4606CD0F42FC" modified="2018-01-31" version="1">MNKPVRHIAVFSGLLVLALLLQATWLQFARGDELSESKWNRRVRIAAFAQPRGNIIVGGHPITGSTETTGSDLKWKRTYTDGPLYAPVTGFFSQIYGGTQLEAESVDGKWLSGSDDRLFLRRTADMLTGKKPRGGDVVTTIDPDAQKAAYQGLGKYKGAVVAIEPATGKILAMASTPSYDPSVFAGSSGEDKKAWTALEGDKDKPMANRALKERFPPGSTFKILTAAAALDHGIVSDIDAPSGAPAPYTLPGTRTQVRNDIPSAPCDKASLKVAMQWSCNNVFLDLAARLGKDRMRETAEKFGFNDAKVDTPVRAAKSVYPSDIDKAQTALTGMGQGSLDATPLQIAMMTAALANDGKLMKPSMVDSLRSPDLSTVEKHKPEVMDQAVSADAARKVQQMMENTAGEGTGKPALIDGLTVGAKTGTAQHGVDNKETPYAWFVSYAKNGEGKSVAVAVFIDPRGSDIARDDVHGGTLAGPIAKKVMESVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEW0</accession>
    <name>A0A2G1XEW0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_26945</name>
        <name evidence="10" type="ORF">CYQ11_18690</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49763">
        <property type="protein sequence ID" value="PHQ49763"/>
        <property type="gene ID" value="BLA24_26945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16657">
        <property type="protein sequence ID" value="PPT16657"/>
        <property type="gene ID" value="CYQ11_18690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758480" description="Beta-N-acetylhexosaminidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="8">
        <location>
            <begin position="78"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="7">
        <location>
            <begin position="201"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="548" mass="58472" checksum="B5BB8C22B67B68BB" modified="2018-01-31" version="1">MGLPVRVTRTSAIRGTMAGLALLTTMSLMGCPARHGSLRPGDDSRSPQSAASSSASPSPAPPGSAAAPAPAPVPPGAPRTVPAVREFTQRAGPGWRPAPGARVVADPGGPLADEGRKLAGDLQLGFGAGPARAGDVELTLRPGQPGGPESYELATRDRKVTITAPDEAGVFYGTRTVLQAVRSGGGLPEGDVHDRPDRAQRGLNLDTARKNFTADWIEGRLREMADLKLNQLGLHFSDDQGFRIESSSHPEIVSPEHLTKAEVRRITALAGSLHITVVPEIDSPGHLGAVIAAHPGLQLRDASGTAARGAVDIANPQSARIVDDLLREYAPLFPGAWFHLGADEYRALMAKDPQASYPRLAEAARRKYGARARVQDLATGWLNDRAAVVRSVGKTPKAWNDGFFPGGVVSPDKGVQVEYWTGKELGARPPQDYLNEGRTLVNLNDEYLYYVLGEPNQFRYPTGERIYRDWSPGVLRGTTAVAQAQSGPDRVAGGRLAVWCDRAQAQTADQVAAGIRMPLAAVAQRLWDPRPPRLAWADFTALAGRVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEX9</accession>
    <name>A0A2G1XEX9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19255</name>
        <name evidence="5" type="ORF">CYQ11_11545</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49790">
        <property type="protein sequence ID" value="PHQ49790"/>
        <property type="gene ID" value="BLA24_19255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13434">
        <property type="protein sequence ID" value="PPT13434"/>
        <property type="gene ID" value="CYQ11_11545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036761">
        <property type="entry name" value="GDH_Mll4104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1668" mass="184635" checksum="C7976514639FDD77" modified="2018-01-31" version="1">MQTKLDEAKAELLERAARVAENVPAGGQQPVGGKGEGGFDRATLTAYLQRYYLHTAPEDLTGRDPVDIYGAAISHYRLAEKRPQGTANVRVHTPTVEENGWTSSHSVVEVVTDDMPFLVDSVTNELSRQNRGIHVVIHPQVVVRRDVTGRLLEVHGPACDAHGSGKDAELPHDALVESWIHVEIDRETDRDDLKQIAADLVRVLSDVRETVEDWGKMRDTALRVADGLADEPTDDIPGTELDEARELLRWLASDHFTFLGYREYDLTKAATDAGEEDVLTAVPGTGLGILRSDPTHTADGHHDGHHAPLARPSSPSFSRLPADARAKAREHKLLVLTKANSRATVHRPSYLDYIGVKKFDAAGNVIGERRFLGLFSSAAYTESVRRVPVIRRKVAQVLDDAGFRPDSHDGRDLLQILETYPRDELFQTPTDQLRAIATSVLYLQERRRLRLYLRRDEYGRYYSALVYLPRDRYTTAVRLRLIDILKEELGGTSVDFTAWNTESVLSRLHFVVRVEPGASLPDLTDADVERIEARLVEAARSWADGFAETLTAEVGEERSAELLRRYSHAFPEGYKADHSPRSAVSDLAHLERLTSVGGGHDFELSLYEPVGAGPGERRFKIYRTGEPVSLSAVLPVLQRLGVEVVDERPYELRCSDRTTAWIYDFGLRLPEHVEGDDARGRFQDAFAAVWTGDAENDNFNCLVLRAGLDWRQAMVLRAYAKYLRQAGSTFSQAYMEDTLRNNVHITRLLVNLFEARMSPSLQRAGTELTDGLLEELDGALDQVASLDEDRILRSFLTVIKATLRTNHFQRDAQGAPHGYLSLKLDPQAIPDLPAPRPAFEIWVYSPRVEGVHLRFGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNTVIVPVGAKGGFVGKRLPDPSVDRDAWLAEGIASYRTFISGLLDITDNMVGGEVVPPKDVVRHDGDDTYLVVAADKGTATFSDIANEVAESYGFWLGDAFASGGSAGYDHKGMGITARGAWESVKRHFQELGHNTQTQDFTVVGVGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFLDPTPDAAVSYAERRRLFELPRSSWADYDTALLSPGGGVHPRTAKSIPINAQVRAALGIEPGVTKMTPAELMKAILSSPVDLLWNGGIGTYVKASTESHGDVGDKANDAIRVDGGDLRVKVVGEGGNLGLTQLGRIEFALSGGPESTGGRVNTDAIDNSAGVDTSDHEVNIKVLLNGLVTDGDMTVKQRNKLLAEMTDEVGELVLRNNYAQNVALANAVAQAPSLLHAHQRVMRRLSREGHLDRALEFLPSDRQIRERLSAGRGLTQPELAVLLAYIKITAAEELLTTGLPDDPYLQRLLYAYFPQPLRQSFGEQIDKHALRREIVTTVLVNDTVNSGGSTFLHRLREETGASLEEIVRAQAAAREIFALNEVWDAVEALDNVVAADAQTRIRLHSRRLVERGTRWLLNNRPQPLQLAETIEFFRDGVETVWAELPKLLRGEDLEWWQSIHDELVAAGVPAELAVKVAGFSSVFPALDVVATADRTGKQLLDVAEVYYDLGDRLHITQLMDRIIELPRADRWQSMARASIREDLYAAHAALTAEVLSVGNGASTPEQRFAEWEEKNAAILTRARTTLDEIRGSDSFDLANLSVAMRTMRTLLRTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF04</accession>
    <name>A0A2G1XF04_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19385</name>
        <name evidence="4" type="ORF">CYQ11_11415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49814">
        <property type="protein sequence ID" value="PHQ49814"/>
        <property type="gene ID" value="BLA24_19385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13410">
        <property type="protein sequence ID" value="PPT13410"/>
        <property type="gene ID" value="CYQ11_11415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="379" mass="40324" checksum="9041078304BFB65B" modified="2018-01-31" version="1">MTAGALWLGGGGPAAAADGGRGDVHVLLNSAYDNRPGELIDIEVRGVRSTGDVTVSSPVFGHRVRLAPDRHGEGGHHARPVIDEGVRPGTYPLAVHAGGRVVAEDHVEVKASHKPEFQVGAVEDVLRPGERLTLWFDDLYPGEKGDSFTATSPAFRAPVRLAHDPKGGYWNNPRMFTAALALPQDLKDGTYKVALAGPDGRRIDEKPLRVRAARPGDSDYTGRVRGPAFFAPSGSPDTARAHSHKAGPGDTVNVLWRDASPDPGEEDRLTATSPAFERPVPLKRDDSKAGDGDDPRYYGPARLRDGLGAGRYPVTVISHHGRVKRTGHLLVKAEEAAAVGLDEPDRTLLIAGASMGAAALAVMGGVLLLRRRDRLRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF58</accession>
    <name>A0A2G1XF58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoaD/ThiS family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_19680</name>
        <name evidence="2" type="ORF">CYQ11_11115</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49863">
        <property type="protein sequence ID" value="PHQ49863"/>
        <property type="gene ID" value="BLA24_19680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13361">
        <property type="protein sequence ID" value="PPT13361"/>
        <property type="gene ID" value="CYQ11_11115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="95" mass="10198" checksum="609BD068F0B9FC09" modified="2018-01-31" version="1">MAIEVRIPTILRTYTDGQKAVEGGGATIDELFKDLESRHPGIRERLVDEAAGGELRRFVNVYLNDEDVRFLAGIGTELADGDSVTILPAVAGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB0</accession>
    <name>A0A2G1XFB0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10990</name>
        <name evidence="3" type="ORF">BLA24_11015</name>
        <name evidence="1" type="ORF">BLA24_19415</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000130">
        <property type="protein sequence ID" value="PHQ51901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000130">
        <property type="protein sequence ID" value="PHQ51902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49819">
        <property type="protein sequence ID" value="PHQ49819"/>
        <property type="gene ID" value="BLA24_19415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51901">
        <property type="protein sequence ID" value="PHQ51901"/>
        <property type="gene ID" value="BLA24_10990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51902">
        <property type="protein sequence ID" value="PHQ51902"/>
        <property type="gene ID" value="BLA24_11015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="121" mass="13869" checksum="7A1093506122841F" modified="2018-01-31" version="1">MGRWLLRLSSGWRRRICGSCFSGWFRRLRNGRRGGWRRRGDREVLAAIIFVATAGCTWNQLPPGFELSGVTAFRGFTEWSEARVWTKLHGLVLDELGSRGELDWSRCAIDSVSVRALKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFE2</accession>
    <name>A0A2G1XFE2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20295</name>
        <name evidence="4" type="ORF">CYQ11_10490</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49960">
        <property type="protein sequence ID" value="PHQ49960"/>
        <property type="gene ID" value="BLA24_20295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13262">
        <property type="protein sequence ID" value="PPT13262"/>
        <property type="gene ID" value="CYQ11_10490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="17917" checksum="F9696CF87D028A4C" modified="2018-01-31" version="1">MAWTLRPPAHRVGPPARRWWTAQALLVVTGPAVLAATVLLVLSLLFFPGALPWLAPLVVVGLVVPALGYALAMPALRYRAHAWEVGESALYASSGWYRLRRRVLPLARVESVALRRGPLQRRFGLATVAVTTASSAADVRITGVSGTEARRLADRLRAAAGLPAGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFJ4</accession>
    <name>A0A2G1XFJ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ROK family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20580</name>
        <name evidence="4" type="ORF">CYQ11_10200</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50010">
        <property type="protein sequence ID" value="PHQ50010"/>
        <property type="gene ID" value="BLA24_20580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13212">
        <property type="protein sequence ID" value="PPT13212"/>
        <property type="gene ID" value="CYQ11_10200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="39016" checksum="0AB95E2DD9DFE9EF" modified="2018-01-31" version="1">MNDRAALDLLVAHGPLTRTRLGELTGLSKPTASQLLGRLEAAGLVRATGNVTGRPGPSALLYEVNPGIAHVAALAVDEEGISAAVADITGAVLGEHRTRARATDEPGRARTVEQVAEAFTAALGAAGITARDVHRTVVATHGALDPRTGRLRYAAHLPGWSSLVLPDDLAEATGTPVTIENDVNLAALAERHEGAARDCRNFVLLWADEGVGAAVVLGGTLLRGAHGGAGEIGYMPLPGAPLARGGPETFAGPDAGGGFQMLAGSPAVLRLARAHGIDAATVSEALALAAATPGAGEAVLAELAARLATGLAAVVAVVDPELVVLSGEVCRAGGERLRDLVETELTGLALPRPRLRLSALKEAPVLTGALQVALADVRDTAFDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFR2</accession>
    <name>A0A2G1XFR2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rsfS</name>
        <name evidence="4" type="ORF">BLA24_21005</name>
        <name evidence="5" type="ORF">CYQ11_09780</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50078">
        <property type="protein sequence ID" value="PHQ50078"/>
        <property type="gene ID" value="BLA24_21005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13141">
        <property type="protein sequence ID" value="PPT13141"/>
        <property type="gene ID" value="CYQ11_09780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="146" mass="16149" checksum="569D422201410DBC" modified="2018-01-31" version="1">MTATDRSIELIQAAAQAAADKLAHDVIAYDVSDVLSITDAFLLASAPNDRQVKSIVDEIEERLLKELGAKPVRREGDRDARWVLLDYVDIVVHVQHSEERVFYALERLWKDCPEIELPADAAATRGKAEEHARAQAGEADLDGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFY2</accession>
    <name>A0A2G1XFY2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03690</name>
        <name evidence="3" type="ORF">BLA24_03705</name>
        <name evidence="1" type="ORF">BLA24_21445</name>
        <name evidence="4" type="ORF">CYQ11_09340</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000051">
        <property type="protein sequence ID" value="PHQ53089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000051">
        <property type="protein sequence ID" value="PHQ53090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50148">
        <property type="protein sequence ID" value="PHQ50148"/>
        <property type="gene ID" value="BLA24_21445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53089">
        <property type="protein sequence ID" value="PHQ53089"/>
        <property type="gene ID" value="BLA24_03690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53090">
        <property type="protein sequence ID" value="PHQ53090"/>
        <property type="gene ID" value="BLA24_03705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13069">
        <property type="protein sequence ID" value="PPT13069"/>
        <property type="gene ID" value="CYQ11_09340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18118" checksum="BBC111258F62708C" modified="2018-01-31" version="1">MLAFDRGWRREARSAWWCGTALGGALLLVDLARGGLDWPRGCAWTVLGAALVAILWPPRVTAGENWLSARGLLREQRVRTDLLTRVRRADGMAPRLILRDVGGGRVELDPRVLADNPLLWHRLDTGVRRSRASGLLRDGTAPLTALAERVDGEGARRLLKSAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFY5</accession>
    <name>A0A2G1XFY5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21225</name>
        <name evidence="4" type="ORF">CYQ11_09560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50111">
        <property type="protein sequence ID" value="PHQ50111"/>
        <property type="gene ID" value="BLA24_21225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13108">
        <property type="protein sequence ID" value="PPT13108"/>
        <property type="gene ID" value="CYQ11_09560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="118" mass="12283" checksum="29D814EC1504EC8A" modified="2018-01-31" version="1">MAGEPQADCLFCKIVKGDVPATVVKETETTVAFRDINPQAPVHVLVIPKVHYPDAASLAAAEPAVAADVLREAGEVALQENGDSGFRIVFNTGAGAGQTVFHAHAHVLGGRGFNWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG81</accession>
    <name>A0A2G1XG81_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nif3-like dinuclear metal center hexameric protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22070</name>
        <name evidence="3" type="ORF">CYQ11_08715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50250">
        <property type="protein sequence ID" value="PHQ50250"/>
        <property type="gene ID" value="BLA24_22070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12965">
        <property type="protein sequence ID" value="PPT12965"/>
        <property type="gene ID" value="CYQ11_08715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="279" mass="29542" checksum="B9C2DC1F13AFF383" modified="2018-01-31" version="1">MPALSEVIAALEALWPPERAEQWDAVGTVCGDPDAPVGTVLFAVDPVQEVVDEAVRLGADLVVAHHPLYLRGTTTVAAHTFKGRVVHTLIKNDIALHVAHTNADSADPGVSDALAGALDLRVTGPLVPDPTDPHGRRGLGRLCELDPPMSLADFAERAAGRLPATAQGIRVAGDPARTIRTVAVCGGSGDSLFDQVRESGADAYVTADLRHHPASEAQQHSPLALVDAAHWATEWPWTEQAAAQLDEISDRHGWGLRTHVSRTVTDPWTAHAASSGHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGJ8</accession>
    <name>A0A2G1XGJ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19770</name>
        <name evidence="3" type="ORF">CYQ11_11020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50363">
        <property type="protein sequence ID" value="PHQ50363"/>
        <property type="gene ID" value="BLA24_19770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16488">
        <property type="protein sequence ID" value="PPT16488"/>
        <property type="gene ID" value="CYQ11_11020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="254" mass="27436" checksum="85BB63D63A61E7F8" modified="2018-01-31" version="1">MWVRSTMAYRTSFVMMTAGNFLGSGLDFAGILIMFSHIEVLGGFSLAEVAFLYGATSVSFGLADLLLGNMDRVGRRVRDGTMDTLLVRPVPVLAQVAADRFALRRLGRVTQGTLVLVWSLSRLDIAWTPVRLLLVPVMLVSGAAIYGAVFVAGAAFQFWANDASEVQNAFTYGGATLLQYPPTVFATELVRGVTFVVPLAFVNWLPAQRVLGRDDPLGLPGWLDFASPLVALACWVPAALAWRAGLRGYRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGM4</accession>
    <name>A0A2G1XGM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20470</name>
        <name evidence="3" type="ORF">CYQ11_10315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50382">
        <property type="protein sequence ID" value="PHQ50382"/>
        <property type="gene ID" value="BLA24_20470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16469">
        <property type="protein sequence ID" value="PPT16469"/>
        <property type="gene ID" value="CYQ11_10315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="59" mass="6995" checksum="084B6CDE5DAA0EB4" modified="2018-01-31" version="1">MRSMLTLAELCAELRISPSTFYDWRAKGRAPRCIKLPNGDLRIRRSDLNTWLDDREDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX3</accession>
    <name>A0A2G1XGX3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16730</name>
        <name evidence="4" type="ORF">CYQ11_16555</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50483">
        <property type="protein sequence ID" value="PHQ50483"/>
        <property type="gene ID" value="BLA24_16730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14262">
        <property type="protein sequence ID" value="PPT14262"/>
        <property type="gene ID" value="CYQ11_16555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304785" description="Beta-lactamase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="390" mass="41236" checksum="690F1451CBC3B736" modified="2018-01-31" version="1">MRRTTTAVSALLAAAAVLSTAVPALAAPSSVAARPVAARDGLQRALDAAVAAGIPGAVAEVRDESGVWRGSSGVTALDGGRAARGDERFRAGSVTKSFVATVVLQLVAEGELGLDDDIERHLPGLVPDGGHITVRQLLNHTSGLADYFKVLLPDLKALPTLQKATYTPRELVALAVKAGEERKGPKPVPGRTWDYSNTNYVVLGLLVEKVTGRSLGSEITRRLIRPLHLTGTSFPDSARLTGRHLNGYERLGAAPGAGPFVDFTAFNPSTIWAAGTLISTTHDLNRFYRALLGGELLPQNLLREMRTMQPMGDDRPGRAYGLGLEENWNLCAADGPVVGHTGSVAGYNTFSVTTADGKRQITLALSTDFTKTPEADKAANRVLITALCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH30</accession>
    <name>A0A2G1XH30_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17110</name>
        <name evidence="8" type="ORF">CYQ11_16165</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50537">
        <property type="protein sequence ID" value="PHQ50537"/>
        <property type="gene ID" value="BLA24_17110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14209">
        <property type="protein sequence ID" value="PPT14209"/>
        <property type="gene ID" value="CYQ11_16165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="71"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="175"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="414" mass="47272" checksum="DD57D80090EFD6DF" modified="2018-01-31" version="1">MTRSRQPNGASSIYQAKDGRWHGRVTVGVKDDGTPDRRHVSSKTRAEVTKKVRELERQRDAGTVRKAGQSWTVKTWLTHWVENIAALHVSENTIDGYRVAVYHHLIPGLGAHRLEKLEPEHLERFYKKMQDTGSAAGTAHQAHRTVRAALNEAVRRRHITVNPATIAKAPRLEEEEVEPYSVEEVQRLLLEAERHRNTARWVIALALGLRQGEVLGLQWTDVDWEAGVIRVSRGRLRPRYKHGCGNRCGRNPGYCPQKINIRRETKNTKSRAGKRPIGVPEELMKLLRRHKEEQDRERRLARDLWVEKGYVFTSPTGEPLNPNTDYHKWKDLLKAAGVREGRLHDARHTAATVLLILGVPDAIVDAIMGWEPGKSARMRRRYQHLTGRVLQDTAAKVGGLLWGSDKRYGDSNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHC0</accession>
    <name>A0A2G1XHC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ORF">BLA24_17670</name>
        <name evidence="9" type="ORF">CYQ11_15605</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50626">
        <property type="protein sequence ID" value="PHQ50626"/>
        <property type="gene ID" value="BLA24_17670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14119">
        <property type="protein sequence ID" value="PPT14119"/>
        <property type="gene ID" value="CYQ11_15605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="36710" checksum="05AF20BA0C2CCD04" modified="2018-01-31" version="1">MHLHDFWFLLIAVLWTGYFFLEGFDFGIGVLTKTLAEDRTERRVLINTIGPVWDGNEVWLITAAGATFAAFPDWYATLFSGFYLPLLAILVCLIVRGVAFEYRHKRPEERWQRNWENAIFWCSLLPAFLWGVAFAAMVRGVPIGPDKNYSGDVLDLISPYTLLGGLFTLVLFTFHGAVFAALKTTGDIRHRARAHATRYGLAALVLAGAFLAWTQADSGNGRSLPAAVIAAVALLAALVLNRTGREGWAFALSGVTVVAVFAMVFLALFPDVLPSSSDPAWSLTAAGSASSPYTLKIMTWVAGFMTPVILAYQAWTYWVFRKRIGTQHIPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHG3</accession>
    <name>A0A2G1XHG3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="10" type="ORF">BLA24_17985</name>
        <name evidence="11" type="ORF">CYQ11_15290</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50684">
        <property type="protein sequence ID" value="PHQ50684"/>
        <property type="gene ID" value="BLA24_17985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14061">
        <property type="protein sequence ID" value="PPT14061"/>
        <property type="gene ID" value="CYQ11_15290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="374" mass="40574" checksum="D1A91CDCD3486AF1" modified="2018-01-31" version="1">MHVTHLSLADFRSYARAEVPLDPGVTAFVGPNGQGKTNLVEAVGYLATLGSHRVSSDAPLVRMGAERAVIRAAVAQGERQQLVELELNPGRANRARINRSSQVRPRDVLGIVRTVLFAPEDLALVKGDPGERRRFLDELITARSPRMAGVRSDYERVLKQRNTLLKSAAMARRHGGRGMDLSTLDIWDQHLAGVGAELLARRLDLIATLRPLADKAYEALAPGGGPVCFDYKGPASIAGLHAREELQEALLAALGEARKQEIERGVTLVGPHRDDLVLRLGELPAKGYASHGESWSYALALRLASYEVLRSEGNEPVLVLDDVFAELDARRRERLAEMVADGEQVLVTAAVDDDVPGVLSGARYAVAEGTVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHH2</accession>
    <name>A0A2G1XHH2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF881 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18055</name>
        <name evidence="4" type="ORF">CYQ11_15220</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50694">
        <property type="protein sequence ID" value="PHQ50694"/>
        <property type="gene ID" value="BLA24_18055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14051">
        <property type="protein sequence ID" value="PPT14051"/>
        <property type="gene ID" value="CYQ11_15220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="254" mass="27043" checksum="589A2F42EC0FB21B" modified="2018-01-31" version="1">MSNSADSTSGPVRRFRPVRLLTGGVFALAGLIFWMSFNTAQGTNIRTDDSMLRLSDLIQERSHKNKELEDSAAAARAGVDALARRDNGGSAAEDKRLTALEKAAGTQKVAGPGLTVTLTDAPPNATAKIPGVPQPQPNDLVIHQQDLQAVVNALWQGGAQGIEVMDQRLISTSAVRCVGNTLILQGRVYSPPYKVTAVGDRGALRKALDASPAIQNYLQYVAAYGLGWKVDQRDTVTLPGYSGTVDLHVAKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL7</accession>
    <name>A0A2G1XHL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_18225</name>
        <name evidence="6" type="ORF">CYQ11_15050</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50722">
        <property type="protein sequence ID" value="PHQ50722"/>
        <property type="gene ID" value="BLA24_18225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14024">
        <property type="protein sequence ID" value="PPT14024"/>
        <property type="gene ID" value="CYQ11_15050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="170" mass="18845" checksum="93B1B881F70B8BF0" modified="2018-01-31" version="1">MADEQMATSGGRPPARPLDEIDRSILRMLQVDGRASIRSVAERVHVSRANAYARINRLIDDGVIRGFGARVDQERAGHGASAYITMKIVQNSWRSVREKLRELPGAAHIALVSGDFDVLLLVHTKDNRALRELVLTRIQAMEEVLSTRTLLVFEETDLQDLKPPEAPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL9</accession>
    <name>A0A2G1XHL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdenum cofactor guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_18245</name>
        <name evidence="7" type="ORF">CYQ11_15030</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50725">
        <property type="protein sequence ID" value="PHQ50725"/>
        <property type="gene ID" value="BLA24_18245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14020">
        <property type="protein sequence ID" value="PPT14020"/>
        <property type="gene ID" value="CYQ11_15030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6457" evidence="5">
        <location>
            <begin position="195"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="29288" checksum="DD26D8A696912D46" modified="2018-01-31" version="1">MTGYDAVVLAGGAARRLGGADKPGLTVGGRPLIDRVLGACADAGRTVVVGPRRPTARPVDWAREEPPGGGPVAALEAGLRRVTADRVLVLSADLPFLGPGIVRSLLDTLGGPDGPEGALVTDPGGEDHPLVAAYRTEPLRRGLGLLVAEHGTFAGLPLRLLTAELTLTRLPHPLASFDCDTWEDVGAARARIRDDGSVLDEWISAVKAELGIELDVDRAGLLDLARDAAHGVARPAAPLTTFLVGYAAAQRGGGPEAVAEASRLAAALAGRWAAEGRDTKPDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHX4</accession>
    <name>A0A2G1XHX4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="9" type="ORF">BLA24_18880</name>
        <name evidence="10" type="ORF">CYQ11_14400</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50826">
        <property type="protein sequence ID" value="PHQ50826"/>
        <property type="gene ID" value="BLA24_18880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13916">
        <property type="protein sequence ID" value="PPT13916"/>
        <property type="gene ID" value="CYQ11_14400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="212"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="467"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="586"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="749" mass="79832" checksum="01E46B665DBC857A" modified="2018-01-31" version="1">MSLDTVKHAAETPDTDQPWAELGLKQDEYERIRTILGRRPTGAELAMYSVMWSEHCSYKSSKVHLRQFGEKAPENDALLVGIGENAGVVDVGQGYAVTFKVESHNHPSYIEPYQGAATGVGGIVRDILAMGARPVAVMDPLRFGAADHPDTKRVLPGVVAGIGGYGNCLGLPNIGGEVVFDPCYQGNPLVNALCVGVMKHEDIHLAKASGTGNKVILYGARTGGDGIGGVSVLASETFDDSKPTKRPAVQVGDPFQEKLLIECTLEIFREDLVDGIQDLGGAGLSCATSELASAGSGGMRVELDHVPLRDATLSPEEILMSESQERMCAIVEPGKVGRFLEICEKWDVIATVIGEVTDGERLEIFWHGEQIVDVPPRTVAHEGPVYERPYARPDWQDALQADDANKLARPGTPEELRAQVLKVISSPNQASKSWITDQYDRFVQGNTVLAQPEDSGMVRIDEDTNLGVAVATDGNGRYAKLDPYAGAQLALAESYRNVAATGARPLAISNCLNFGSPEDPAVMWQFAEATRGLADGCLALGTPVTGGNVSLYNQTGETAIHPTPVVAVLGVIDDVDRRTPMAFSDEGHLLYLLGDTKEELGGSAWSQVIHDHLGGLPPAVDLDREKLLAEILIAASRDGMVDAAHDLSDGGLIQALVESCLRGGKGARIVVPDGTDPFVFLFSESAGRAVVAVPRSEELRFTDMCGARGLPATRIGVVDGEALDVQGQFAIPLTELRTAHEATIPSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI11</accession>
    <name>A0A2G1XI11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16630</name>
        <name evidence="4" type="ORF">CYQ11_16655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50860">
        <property type="protein sequence ID" value="PHQ50860"/>
        <property type="gene ID" value="BLA24_16630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16612">
        <property type="protein sequence ID" value="PPT16612"/>
        <property type="gene ID" value="CYQ11_16655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="231" mass="24084" checksum="A212BE225B1B4D4E" modified="2018-01-31" version="1">MLWGPHPQPRRGPKPALSLDGIARAGVAIADAEGLPALSMQRVAEHLGKTKMSLYRYVPGRAELVALMVEAAIGAPPEPDAGVWRARLTNWSHALSAVFAHHPWLLDVTVGPRLMGPNELAWMERALAALEGLGLTGGERMDAVVLLTGHVRGIALQSRAAGAGGAEAQLVAALGEVMREHGDGYPSLLAAMASSAEPLAQDQALAFGLERILDGLEVLIARRAGGSPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIN4</accession>
    <name>A0A2G1XIN4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15010</name>
        <name evidence="4" type="ORF">CYQ11_13060</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51083">
        <property type="protein sequence ID" value="PHQ51083"/>
        <property type="gene ID" value="BLA24_15010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13694">
        <property type="protein sequence ID" value="PPT13694"/>
        <property type="gene ID" value="CYQ11_13060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304667" evidence="1">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="178" mass="18674" checksum="0DEA0981129157DA" modified="2018-01-31" version="1">MTTTANRILYLVCCAAAPAVRVADGVRAAQDAGWDVCLILTPYAHRWLEADVPALRELTGHPVRHEYKLPGQPDVLPPPDAILVAPATFNTLNKWAAGISDTLALGLVTEAIGLGLPMAALPHLGAAQAAHPALSRSVDFLRAAGVTVLLGEDGYDPGRGDRVETYPWERGVAALAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIP2</accession>
    <name>A0A2G1XIP2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14925</name>
        <name evidence="4" type="ORF">CYQ11_13145</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51070">
        <property type="protein sequence ID" value="PHQ51070"/>
        <property type="gene ID" value="BLA24_14925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16533">
        <property type="protein sequence ID" value="PPT16533"/>
        <property type="gene ID" value="CYQ11_13145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="2">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="153" mass="16758" checksum="4B726CC3EFFD8145" modified="2018-01-31" version="1">MVRGHRVLRSDVTPARYRQHGRPRGRLNSEHRPRPPPYPTRSHAVHVIEVKDAELMSAIARRSKELGITNAAIVSLIGAVDAFTVSTMPVSDATADVITRYDIPAEMHGSGEITEGTVHIHATMAVEGDRAVCGHVHEAHVGTWFARAYVLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIX6</accession>
    <name>A0A2G1XIX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15040</name>
        <name evidence="4" type="ORF">CYQ11_13030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51089">
        <property type="protein sequence ID" value="PHQ51089"/>
        <property type="gene ID" value="BLA24_15040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13688">
        <property type="protein sequence ID" value="PPT13688"/>
        <property type="gene ID" value="CYQ11_13030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="35"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="254" mass="27237" checksum="C04FAEF6AC9838B8" modified="2018-01-31" version="1">MYLISVNVGRSRTTGDLPGTEGSFTDGLETGIDKRPVEGAVAVASPGPKGTAGSGVAGDHVVDLRHHGGDHQAVYAFAREDLDGWERELGRPLPGGSFGENLTTSGLDVNGARIGERWRIGTDLLLEVTAPRIPCRTFADWLGERGWIRRFTQEAAPGAYLRVIEPGQIRAGDPITVVHRPGHDVTISHTFRALTTERALLPTLLEAGDALEPRLREKALAYTERQKEATGGPEGRRETADGHQQAAASTNVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ09</accession>
    <name>A0A2G1XJ09_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="8" type="ORF">BLA24_15905</name>
        <name evidence="9" type="ORF">CYQ11_12170</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51238">
        <property type="protein sequence ID" value="PHQ51238"/>
        <property type="gene ID" value="BLA24_15905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13538">
        <property type="protein sequence ID" value="PPT13538"/>
        <property type="gene ID" value="CYQ11_12170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="187" mass="19576" checksum="08B0C646715158CC" modified="2018-01-31" version="1">MSEVKLAAAVRTDFGKGAARRIRRAHQVPAVVYGHGGEPVHVSLPGHDLMMALKTPNVLLSLDIEGRNELVIPKQVQRDALKGFLEHVDLLVVKRGEKVTVEIPVQTEGDLAPGGNLLEHTLTALPVEAEATHIPEAVTVSIAGLDAGASVLAKDVVLPAGVELAVEAETVVLHVVAGQVEAEGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ54</accession>
    <name>A0A2G1XJ54_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ORF">BLA24_16220</name>
        <name evidence="8" type="ORF">CYQ11_11855</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51288">
        <property type="protein sequence ID" value="PHQ51288"/>
        <property type="gene ID" value="BLA24_16220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13487">
        <property type="protein sequence ID" value="PPT13487"/>
        <property type="gene ID" value="CYQ11_11855"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="18210" checksum="C336C657B3A79DBA" modified="2018-01-31" version="1">MTGSPVVGIVMGSDSDWPVMEAAAKALDEFEIPYEVDVVSAHRMPREMVAYGEQAAGRGLKAIIAGAGGAAHLPGMLASVTPLPVIGVPVPLKYLDGMDSLLSIVQMPAGVPVATVSVAGARNAGLLAVRMLAAHDGDLLERMRGFQDELNQQATEKGKRLRARTEGATGFGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ57</accession>
    <name>A0A2G1XJ57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_16180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51282">
        <property type="protein sequence ID" value="PHQ51282"/>
        <property type="gene ID" value="BLA24_16180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013847774" evidence="6">
        <location>
            <begin position="28"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="263" mass="25054" checksum="66C580309541F46A" modified="2018-01-31" version="1">MRRGGALAVTAALAGGAIALAAPVAHAETVDVNYQCKTPIGDKSAVSPIDIKAVADGNAYKLTMSFQKGVSSSPVELGKGAMKPSAVIKLGGADSGNVAVAGPANDQPIPANTPIKISDLSGTYTPKKSGQVTFTASTLTIMALGTTTTCEPSNNPKPSLTLDVKAPGGTTGGTTGGSTSGTTGGSTAGSTGGSTAGTSGGSTGGASAGTAGTAATGGSTGGGQLPQTGPSDSALALGTLGGTVFLTGVAGTLWLTRRRRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJE2</accession>
    <name>A0A2G1XJE2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein BLA24_16410</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16410</name>
        <name evidence="3" type="ORF">CYQ11_11665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51320">
        <property type="protein sequence ID" value="PHQ51320"/>
        <property type="gene ID" value="BLA24_16410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13454">
        <property type="protein sequence ID" value="PPT13454"/>
        <property type="gene ID" value="CYQ11_11665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6504" checksum="1926D4FA6915FF13" modified="2018-01-31" version="1">MPLEAGLLEILACPACHASLREENATEETPELVCQGDSCGLAYPVRDGIPVLLVDEARRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJF7</accession>
    <name>A0A2G1XJF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MxaD family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13685</name>
        <name evidence="2" type="ORF">CYQ11_01380</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51388">
        <property type="protein sequence ID" value="PHQ51388"/>
        <property type="gene ID" value="BLA24_13685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11728">
        <property type="protein sequence ID" value="PPT11728"/>
        <property type="gene ID" value="CYQ11_01380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="155" mass="17244" checksum="6C69E5E2FF96E9C8" modified="2018-01-31" version="1">METLTVRRVIAAPIDDVFDWCATTTNYTRTPFVLKARLARPGAGAPYGVGAVRLHTWLIGWFRERVTAYNRPHAFDYDVERSFPPARHELGRMTFTAVDEGTLVVWTTTFQVRLPFGAAITRRFAKPVIAHVFGKILEAAGTALTEAPASRAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJN8</accession>
    <name>A0A2G1XJN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4190 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13895</name>
        <name evidence="4" type="ORF">CYQ11_01590</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51420">
        <property type="protein sequence ID" value="PHQ51420"/>
        <property type="gene ID" value="BLA24_13895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11761">
        <property type="protein sequence ID" value="PPT11761"/>
        <property type="gene ID" value="CYQ11_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="2">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="116" mass="11752" checksum="FC02333CD3CC38E5" modified="2018-01-31" version="1">MSSGTTGSVRTTPSKNGPAKVSLWFAGCGVAAYGNFATGIAWLNPGVFIMMAVLCALIAIVAGHIGRFRGRRLDGDGRGMALLGIVVGWLVILVTVVIALAVGGLIAGLAVLVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJS3</accession>
    <name>A0A2G1XJS3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13250</name>
        <name evidence="3" type="ORF">CYQ11_00970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51476">
        <property type="protein sequence ID" value="PHQ51476"/>
        <property type="gene ID" value="BLA24_13250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11658">
        <property type="protein sequence ID" value="PPT11658"/>
        <property type="gene ID" value="CYQ11_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="30199" checksum="2DC4C021A16C22D9" modified="2018-01-31" version="1">MGDRYVPHAFSHIDAHPNPVRLVDALYRLRAEPFFASYKRRLRQLLQAQPGQRFLDVGAGTGDAARELAAETGAETIACDLSQTMCAEMKRAGLEQVVVADSHCLPFQDAGFDGVWADRVLQHVESPARTLDEMVRVTRPGGRIVVCDPDTATQALDIDDHRLASKVLGLRQSVSIRHGTFARRVPGLLTARGLLDVEVEPHTLVIRDKRAVDGTMGIRDWADVFADRGHLDRSEARRFNALLDDAVEGNRFLYAVTYFLTSATVPTVRTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJT1</accession>
    <name>A0A2G1XJT1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_13365</name>
        <name evidence="5" type="ORF">CYQ11_01085</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51493">
        <property type="protein sequence ID" value="PHQ51493"/>
        <property type="gene ID" value="BLA24_13365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11675">
        <property type="protein sequence ID" value="PPT11675"/>
        <property type="gene ID" value="CYQ11_01085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304741" evidence="2">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="336" mass="34547" checksum="3DE3C5C2A2E8BA0D" modified="2018-01-31" version="1">MVSVDVTVLGLGPMGSALADAFVAAGCRTTVWNRTPGKADALVAKGAVQAASAGEALAASPLTVVVLSTHEAVQEVLHPLADGLAGRTLVNLTSGSPPCARETAAWAQRGGAAYLDGVILTTPSAVGSPGFLQLYAGPPEVFDAHRATLAALGDPVYLGTDPSLPSVYDTALLCQMWATLTGWLHSVVLVGADGPGGGVTATTYTEVANRWMDTVRFFMSAYARQVDSGQCPGGDFPLDLHRMLMRILSDASELRGADTGLPELFTALTERAVAAGHGADSYARLVEFVRTESRPDAALSSSARSPADGGAGEPPSCACRGVRGGVVDRRAGRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJW7</accession>
    <name>A0A2G1XJW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_13610</name>
        <name evidence="4" type="ORF">BLA24_30085</name>
        <name evidence="6" type="ORF">CYQ11_01330</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000166">
        <property type="protein sequence ID" value="PHQ48400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48400">
        <property type="protein sequence ID" value="PHQ48400"/>
        <property type="gene ID" value="BLA24_30085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51535">
        <property type="protein sequence ID" value="PHQ51535"/>
        <property type="gene ID" value="BLA24_13610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11719">
        <property type="protein sequence ID" value="PPT11719"/>
        <property type="gene ID" value="CYQ11_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="29835" checksum="A50554C9FFECC1BD" modified="2018-01-31" version="1">MTLRKSQVRDRPDRHGESALAGVVLAGGNTGLNARGGTVPHFAVHEGYAVYEGPATDSSFHMHAAFQVAIAVRGEVLMVDASGTRHQAVALIVPPMVRHRMLAVPHLLTFFVEPQCAFADRLRERCGPGVTADPELRDLREEDVRSATGRPAEGLDGRLLAAMNALADQRVPMPVLSAQVGLSPQRLRALARQQLGMPLPRWRIWQRLARATEALREGRSLADAATTAGFADQAHFNRQMREMLGLAPSFLLPGPRRPAEGPSGAARGMGGDGSADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKA3</accession>
    <name>A0A2G1XKA3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pstC</name>
        <name evidence="12" type="ORF">BLA24_12770</name>
        <name evidence="13" type="ORF">CYQ11_17125</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51569">
        <property type="protein sequence ID" value="PHQ51569"/>
        <property type="gene ID" value="BLA24_12770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14361">
        <property type="protein sequence ID" value="PPT14361"/>
        <property type="gene ID" value="CYQ11_17125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="94"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="331" mass="34645" checksum="2E1B15719F3EA103" modified="2018-01-31" version="1">MDITSATAAGPPPAPENGRTVAEQGGGTARVGDRIFLGLSRGSGILLLVIMAAIAVFLTIRAASALSHDEGDFFTTFEWNANATPPVFGIAVLAFGTVVSSVIAMLLAVPVAIGIALFISHYAPRRLAAPLSYVVDLLAAVPSIVYGLWGALFLVPHLSGLYGWLNDYFGWTGVFAYHDGAARSLFTIGILLAIMILPIVTSVSREVFLQAPKMHEEAALALGATRWEVIRMSVLPFGRSGVISASMLGLGRALGETMAVATVLSPSFEIGKSLLDPGGGTFAQNIASSFKESGEIGKDALIASGLVLFVLTLLVNGAARLIIARRKEYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKC4</accession>
    <name>A0A2G1XKC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_11470</name>
        <name evidence="6" type="ORF">CYQ11_02705</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51704">
        <property type="protein sequence ID" value="PHQ51704"/>
        <property type="gene ID" value="BLA24_11470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11953">
        <property type="protein sequence ID" value="PPT11953"/>
        <property type="gene ID" value="CYQ11_02705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="131"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="597" mass="60585" checksum="A85020C60B36E18B" modified="2018-01-31" version="1">MDRLIPLIVAVPLLGAAVLVGAGRRVPRPVAETAGLLCAAVSAALALVALTRGTAVVWAGDWRPVGGQGVGIVLVGDRAGLGLVVLASLLVLAVQVYSWHYFDEPPRGHAGAYPALILLFQAGLCAFALNGDLFDAFVYFELMGVVGYALTGYRVEDARAVQGAVNFAFVNSLGGYAMLTGIALLYARTGELGMAQTGRALDASPGPDALVVAAFVLTLTGLLVKAAAVPFHFWLPDAHAVAPTPVCLLLSGVMVETGVYGVARVHTAVFAGPGGVPAATVRGALLVLGVTTALVGAVMCWQQRHVKRLLAFSTVAHTGLFLTGVALLTPEGTAGTCVYVLGHAGAKAALFGCAGILLDRCGSVDEWELHGRGRDIRGVGLLFAAGGLALAGLPPFGTGLGKALVEEQSPWLPALFVLVSAVTGGAVLRVAARVFLGAGDGGGEEAGSAEPETTGDDEEPETGRRLRLPPPPMVAVPALLLAGALAVGTVPALARGAAAAARGLTDHAAYAATVLGGPAGGPTAEAHAWWTVSGVGLGLLSAALACALALAAVRRWVPAGGWSAPLRRLHSGHVGDYVAWTVAGVGLLSLLTWWPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKE9</accession>
    <name>A0A2G1XKE9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B3_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11635</name>
        <name evidence="3" type="ORF">CYQ11_02875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51734">
        <property type="protein sequence ID" value="PHQ51734"/>
        <property type="gene ID" value="BLA24_11635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11982">
        <property type="protein sequence ID" value="PPT11982"/>
        <property type="gene ID" value="CYQ11_02875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3_4" evidence="1">
        <location>
            <begin position="74"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="25402" checksum="82A819201174FC63" modified="2018-01-31" version="1">MATGTADIKAWLDTVTIDPAVRDLRPDYRALVVVAEGLRPGPSDEASGRLLAAAEESARRWAAGTAVEDHPHLAAWREAFRAFGAKPQRTRPSAEALIRRADAGLPRVDRLTDVYNAVSVAHVLPLGGEDLDHYAGSARLVRATGEEPFETTAGGEAVTEHCPPGEVVWRDDAGVTCRRWNWRQCTRTRLTLATTRAVFILDALGPMDDTALAAAGDALTEALADGSPGASMASRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKV1</accession>
    <name>A0A2G1XKV1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000135">
        <property type="protein sequence ID" value="PHQ51868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51868">
        <property type="protein sequence ID" value="PHQ51868"/>
        <property type="gene ID" value="BLA24_11255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="230" mass="23454" checksum="EDD77FB376AADB33" modified="2018-01-31" version="1" fragment="single">MSLHAAGATRLRVRLAAGPAGSVTLNVADETGAPVASIDALTLRAISADQLARARDPHRDALFRLDWTTVPLPAAEPAGTTAVLGTGGPEIDGAEQYPDLAALTAALDAGKPVPDTVFTVLPPAADAPAHDAVRAVTHRTLGLLQAWLDDARVETARLVLITGGAVATTADEDVTDLANAAVWGLVRSAQSENPDRFVLVDLDAPPAGAPELLAAARAGEPQAALRGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKW6</accession>
    <name>A0A2G1XKW6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000134">
        <property type="protein sequence ID" value="PHQ51870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51870">
        <property type="protein sequence ID" value="PHQ51870"/>
        <property type="gene ID" value="BLA24_11205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="28" mass="3328" checksum="7D3A695393EC14DA" modified="2018-01-31" version="1" fragment="single">MRWTHRRDRLPDTYRAIAGLVSDRSINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKY0</accession>
    <name>A0A2G1XKY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000132">
        <property type="protein sequence ID" value="PHQ51898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51898">
        <property type="protein sequence ID" value="PHQ51898"/>
        <property type="gene ID" value="BLA24_11090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="63" mass="6871" checksum="110DE975C12AC39F" modified="2018-01-31" version="1" fragment="single">MADTHVLFVEDDDVIREATQLALERDGFMVTAVPDGLLGLESFRARRPDIALLDVMVPGLDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKY2</accession>
    <name>A0A2G1XKY2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11155</name>
        <name evidence="3" type="ORF">CYQ11_16870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51887">
        <property type="protein sequence ID" value="PHQ51887"/>
        <property type="gene ID" value="BLA24_11155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14316">
        <property type="protein sequence ID" value="PPT14316"/>
        <property type="gene ID" value="CYQ11_16870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="293"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1107" mass="121678" checksum="640192B6F942547E" modified="2018-01-31" version="1">MRVRSAQDRLVSVHGSKQGSGVLLTERLILTSAHVVEVGHPTWVGVPGDLAPTVCDVLWRGNLDGCDAALLGTQRPVVDVADASGLRLGVVTTREPVRGCQVLGFPWVQRYEGDELEAVQITGTLTPFSGRVRRRYVLQSDHHPPAPMPGGSPWSGLSGGPLFAGPLLVGIVCEDQAGWQHSALAAIPLASLFADRGFTAVLRSQWPQAPPLEELHTPHPEDLAYEARYARALKAAYSRMEVFGLDDLGANDNSWDLDTAYLSLEAMAPVAGDTDGRPRPEPRRIEDLLGPRPRTVLRGEAGAGKTTLVWWLASHAAHRTLPEELSTLNGLVPFVIPMRSLAARGLTAPTPAQLPVIAPLQVDTSPDGWAGRVLEAGRALLLVDGLDELPQAERAPARRWLTGLLRMYPDTRCLVTVRPLAVEDAWLESEGFEELQLLPMSDDDIQAFVAAWHRAARLECDSFGGTPRADQERARLATLERDLSQEFQLNSTLRDLARTPLLCAVICALHRRRSGLLPSTRWHLYEAALSMLLGNRDAYRRVGTPEGIALTIDDSRQLLQRIAVWLVRNGRAELSQKQATRQLKTGMAGLRKVRDQGTPDQVLTHLLNRSGLLQERAADSIQFIHRTFQDYLAAKEFQESDSLDELLGHTVDEQWQDVILLAIGHCGRKEVRRVIARLITAGDTAPERAEQWHLRALAAACATAAPYLDDDQYETVWGGVKALGPPASAGKVELLASLGPDVLPVLPRPDDLSSVEVALMVVSVLRSLGTWAIPLLQLYRLHESRKVREGVAAAWHAMDRRRYVEEVLVGMRLDDVAVHVNTAEELALAPRLGDTGRLVLHGEHTDAQALGRALRDRTVDALELWQNHALENVDFLRGHATLRSLSLMYCSRVRDLSGLRGSALRTLRLTETRLSYAALAGLPDVPDLTTLWFDGLPPDSAGRIPPPHPRVTELQVRHWRDPVRLNDIDSWASLETLHVHGTLASPAELRALAGLPHLHTLSLSPNTVEDLDDVEPLRGVHTLGLTLLEGVLDARLFRTFPALRRLSLRESSGTTVLDLSAVPRLPAPLTVSARLRSHLKVIGAKHLKDQLTLDFSRRPPKETAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKY8</accession>
    <name>A0A2G1XKY8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11170</name>
        <name evidence="5" type="ORF">CYQ11_16885</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51892">
        <property type="protein sequence ID" value="PHQ51892"/>
        <property type="gene ID" value="BLA24_11170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16615">
        <property type="protein sequence ID" value="PPT16615"/>
        <property type="gene ID" value="CYQ11_16885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="152" mass="17217" checksum="BD9E006D4412230D" modified="2018-01-31" version="1">MRRLRLAKDAMDRDWAEPLDLDAVSAHAGYSRFHFVRAFKDAYGQTPGQYLSRRRIERAQELLRTANLSVTEICALVGFSSLGTFSTRFKRQTGLTPTEYRARHAPRGAGHIPGCYAMLWNGGFPLRRDGGQGRDRDRDQGRDQDRNSGEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKZ0</accession>
    <name>A0A2G1XKZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_12245</name>
        <name evidence="11" type="ORF">CYQ11_03480</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51841">
        <property type="protein sequence ID" value="PHQ51841"/>
        <property type="gene ID" value="BLA24_12245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12087">
        <property type="protein sequence ID" value="PPT12087"/>
        <property type="gene ID" value="CYQ11_03480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1461"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3533"/>
            <end position="3608"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1499"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="3568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="3689" mass="386781" checksum="98AB09FD67B9916D" modified="2018-01-31" version="1">MENGDKLRDYLKRATTDLRHARRRVRELEDKDREPIAIVAMSCRYPGGVTSPEELWQLVASETDAVSAPPVNRGWGLEQAADPDSAAAVQGGFLHEADRFDPAFFGISPREALAMDPQQRLLLETAWEAFERAGIDPTSVRGERIGVFAGVMYHDYGARVIKVPEGFEDVAGYLGNGSAGSVASGRVSYTLGLEGPAVTVDTACSSSLVALHLAVQALRREECTMALAGGVTVMASPGIFGEFSRQGGLAGDGRCKAFADSADGMGAAEGVGLLLVERLSDARRNGHEVLAVVRGSAINQDGASNGLTAPNGPSQQRVIRQALAASGLSAAEVDAVEAHGTGTPLGDPIEAQALLATYGRSRPAEQPVWLGSVKSNLGHTQAAAGVAGIIKMVMAMRHGTLPRTLHAETPSSHVEWDSGAVRLLTEARPWPETGQPRRVAVSSFGISGTNAHTVLEQAPAAEESEEEPAAAPLPAPAVVPWVLSGKSDAALRAQAERLRDHLAARPELSPVDVAHSLVTGRAALEHRAVVVGGDLLEGVTAVAEGRPAGTTVQGTAYVTRGKVAFVFPGQGSQWVGMARELVDSSPVFAERMRECDAALSVFVDWSLFDVLGDESALERVDVVQPVLFAVMVSLAELWRSHGVNPAAVVGHSQGEIAAACVAGALSLEDAAKVVALRSKAILALSGLGGMVSVALPVEQVRERLTDGLSIAAVNGPKSVVVSGDVAELDALLAACEADEVRARRIPVDYASHSAHVEAIREELFTSLAGIAPRAAEVPFFSTVTADWCDTTGLDAEYWYTNLRETVRFEEATRALVEQGFRFFVEASAHPVLTVGVQETIEAVNGDAVVVGSLRRDEGGLSRFVTSAAEGWTRGLPVDWSTFVPGGQRVELPTYAFQRERFWLDAVSTDDLAAATADPADAAFWAAVEREDATELAGTLGLDDDVLNAVLPALSSWRRHRVDRARVDDWRYTVSWKPLAFAPSTAAPAGRWLLVTADGEGGEDDLRRLLTDRGAEVLSLTGTGCDREALAERLTALQTDAGEGLSGVLCLLGTDDTPHPAFPVLSQGLAATVALVQALGDAGVEAPLWLLTRGAVSVGRSDRLTSTAQSQVWGFGRVVGLEHPDRWGGLVDVPETLDERTGARLLGVLAGTAADEDQIAVRASGVFVRRLLRAPLGDAPVVRPWTPRGTVLITGGTGALGGHVARWAARGGAEHLVLTSRRGRETAGAAELEAELVELGARVTIAACDVADRDAVARLLAEHPPTAVVHAAGVGQLHPLMDTDLPAFAGILDAKVAGARHLDELLGETELDAFVLFSSNAGVWGGGGQGAYGAANAYLDALAEDRRARGLTATSVAWGAWGGGGMAAQGGTEEHLSKRGIGVMAPELAVSALVQAVEHDEAFVAVADVDWARFVPGFTAARPRPLIADIPEAAKALAVAVSDEVTGVSELAGRLAGLTEAEQVRLVLDLVRSEAAGVLGYGAAEAVEPSRAFREMGFDSLTAVEVRNRLAAATGLKLPATLVFDYPSPTVLADFLRREVTGQTGAAGSAAVSAAGGADDEPIAIVGMACRFPGDVRSPEQLWDLVASGTDAMTPFPAGRGWDVEALFGAGTTFTPEGGFVHDAAEFDAEFFGISPREAMAMDPQQRLLLESAWEVLERAGIDPTSLRGSQTGVFVGTASQGYGAAVAGVEEGVEGYLVTGDATAVMSGRLSYTLGLEGPAVTVDTACSSSLVALHLAAQSLRNGECTMALAGGVTVMINPMAFLEFSRQRGLAGNGRCKPFAEAADGTGWGEGVGLLLVERLSDARRNGHEVLAIVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANAGLQPSDVDAVEAHGTGTTLGDPIEAQALLATYGQDRTEPLRLGSVKSNIGHTQSASGVAGIIKMVMAMRHGVLPESLHIDQPSTQVDWSAGAVELLTETIAWPETGHPRRAGVSSFGVSGTNVHTILEQAPEAAPVETAPAIEGVVPWVLSAKSEAGLREQAERLRERLDAGFSPLDVAYSLATTRTALEHRAVVVGTDQAAFRRGLDLLAEGTTGAGVFTGTARREGLTAILFSGQGSQRAGMGRELYGAFPVFAEALDAVCAEFDRVLDRPLREVLFEHGDALDQTGFTQPGLFALEVALYRLVEAWGVRPDYVTGHSIGELAAAHVAGVLTLEDAVTLVAARGRLMQALPTGGAMLAVGADEATVAAHLEGREAQVSIAAVNGPSSVVIAGDEDVVTELGETFAQLGHKTRRLRVSHAFHSPHMDAMLDDFRKVAEGLTYEQPRIPVVSNLTGQVEDVASADYWVRHVRGAVRFGEGVRWLEDQGVSVFLELGPDGVLSGMAQESLSDEPDLIAALRKDRPEPEALVTALGRLHVAGVTPDWNAFFAGRNARRVDLPTYAFQRKAYWPRAAVLTGDVSSIGQTGAGHPLLGAAVALADSDGYLLTGRLSRQTHPWITDHSVGGAVLLPGTAFVELAIRAGDQVGCDRVAELTLEAPLVLPERGGVHLQLVVGAADDTGSRTLTVHSRAEDASADHPWTRHASGLLAQDTGAQPEPLDVWPPADAEALDVDGFYERLAETGYGYGPAFQGLRAAWRRGDELFAEAEVAETDQADAARFALHPALFDSALHALGLASATEAGQEGTSSGTRLPFSWTGLRLHATGAPAVRVRLARDGSGAVAVTMADAAGHPVASVDALVFREVSGDQLAAARTADNDALFTVEWVTAEEAQPGDVPTGDVAVLGGYAGEAATRFADAFAGSGRSVRTFPGLAELAAADSVPEIVVLPCGDGSEPTAAAVHELTVHALGLLRAWADDERFAGSRLVVLTRGAIAAREGEGTTDPAAAAVWGLARSAQSENPGRFVLADLDGTPASHAALPAALAVDEPQVAVRGAEVLVPRLARAASGDALTPADGPWRIDCPERGTLANVTVVPFPEYAAELGVGQVRIAVRAAGVNFRDVLIALGMYPGEAVMGGEAAGVVTEVAPDVTGLAVGDRVMGMVEKAFGPVAVADRRLVARMPDDWSFEHAASTPAVFLTAYYALRDLAELRPGQKILVHAGAGGVGMAAIQLARHLGAEVFATASPAKWDALRELGLDDDHIASSRDLDFEAKFLISTDGAGVDVVLDSLAREFVDASLRLMPRGGRFLEMGKADVRDPEQVAAEHPGVVYRSFDLGDAGPDGIQRMLLELLGLFGQGALTPLPVRTWDVRQARTALRYVSQAKHVGKIVLTVPRQLDPEGTVLITGATGTLGGLLARHLVTERGVRHLLLLSRRGRDAEGAAELEAELTGLGAEVRFAACDAADRDALADVLGSLERPLTGVVHTAGVVDDGVLSSLTPERVSAVLRPKVDAALNLHELTRDQDLAMFVLFSSAAATFGGAGQGNYAAANAFLDALAQYRRAQGLAGQSLAWGMWAQRSAMTGELGEADLARMNRGGIGALSTEQGMSLFDDATASDRALLVPVRLDLAQLREQGPALPHLFRGLVRVQARRTAAAAVRDERKQGPSLAEQLAGLTEQQRLTVLADLVAQHVASVLGYPSAASVDHKRPFQEMGFDSLTSVELRNRMNTATGLHLPPTLVFDNPTPEALAAHLLDEIPLDDVHAVAPLHAELDKLESMLSTVTLEADDRAQVEARLRAFLAKCADGAEADDAVGDNSDLAAATADEIFDLIDNELGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL05</accession>
    <name>A0A2G1XL05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10750</name>
        <name evidence="3" type="ORF">CYQ11_00800</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51923">
        <property type="protein sequence ID" value="PHQ51923"/>
        <property type="gene ID" value="BLA24_10750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11632">
        <property type="protein sequence ID" value="PPT11632"/>
        <property type="gene ID" value="CYQ11_00800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="314" mass="33708" checksum="79BD6281254A7EB2" modified="2018-01-31" version="1">MHASETGTLTDRYVVEVVRRIPADQRGDVADELRATIADTVEARGLADPENAEREVLTEMGDPIRLAARYADRPLALIGPRLYPTYVRLLTVLLSTVLPLVTALSAVLDILDGQGAGAVIGGAVGAVLSVGAQMIAWLTVVFALIERSGKRAGAVGSAWTPDDLPDRRVSKERGAAGYAGVVWHALLIALIVWQHTAQPYQTDGGTRLDALNPDLWSGWIWPILAGLVGLVTLDAIRAVRVWTRSLAIWSAGAQAAFTLPLAWILHRQELFNPAFLSDANGGWQTPQSLYTVAVVGVLAVGAGEVVKRFREARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLA8</accession>
    <name>A0A2G1XLA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000106">
        <property type="protein sequence ID" value="PHQ52010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52010">
        <property type="protein sequence ID" value="PHQ52010"/>
        <property type="gene ID" value="BLA24_10075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="119" mass="12517" checksum="9156FB162DCA584C" modified="2018-01-31" version="1">MEHSGRVVGGAGGVLVAPAFRRGHEFGGRPYRHGEGQDPLERGEEGEDVHPVGDAVRGPGRRGLFGEGGERRHLPAHPVDGFGRDAQVGARGASRMGFARQRTAQRMGARTALTTLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLG3</accession>
    <name>A0A2G1XLG3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000099">
        <property type="protein sequence ID" value="PHQ52060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52060">
        <property type="protein sequence ID" value="PHQ52060"/>
        <property type="gene ID" value="BLA24_09720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="176" mass="18860" checksum="284C3EF59DEF8C05" modified="2018-01-31" version="1">MVGHLADQLGATVTLRRSAFGGTSAVVIVPSEHLVPAREGTAVPEPAKEPAPVPRPAQPTEERRPKLVARQQTGDPAGDPAPGAPELPRRPRKERVRQAGNTAPETPPRSGSGDVPGRPALPERVPQTHIAQRLREPRADEPVGRDAATPEEVADAWADYEDSTRQVELELRGDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLX2</accession>
    <name>A0A2G1XLX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_08890</name>
        <name evidence="5" type="ORF">CYQ11_04145</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52264">
        <property type="protein sequence ID" value="PHQ52264"/>
        <property type="gene ID" value="BLA24_08890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12196">
        <property type="protein sequence ID" value="PPT12196"/>
        <property type="gene ID" value="CYQ11_04145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="181"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="376" mass="37194" checksum="37584FF89DE0C945" modified="2018-01-31" version="1">MHNSSLPACPSSGGPRTGSGVSVGRGLVYVTVAAVAWGTSGATAALVFDSSGLGPLALTFWRTFGGFLLMLAVLAVRRAPRRQAAPGPYEPKGRRVVRALVVGAGFTVFQAAYFAAVDGTGIAVGTVVTLGAAPVMVALGSRLLMGERLGAGGRVAVAGALAGLAVLMLGGDGTGEVRPAGVAMGLLSGAGYALLTVATRYFGGRGRGTDPFTTTLTSLGVGTVCVLPLALAEGLWPRAHELGRTVGLLAYLVTVPTVLAYGLFFAGLVAVRGTTVTVITLLEPVTAAALAVAFLGEHLTTATAVGTAVLLSAVVALAWAETRGTAASVPVAGGGPVTPEPAGATVATGVAEHDDAGEVRPAQSPASEPLPHPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMD0</accession>
    <name>A0A2G1XMD0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07950</name>
        <name evidence="3" type="ORF">CYQ11_00385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52373">
        <property type="protein sequence ID" value="PHQ52373"/>
        <property type="gene ID" value="BLA24_07950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11575">
        <property type="protein sequence ID" value="PPT11575"/>
        <property type="gene ID" value="CYQ11_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="124" mass="13633" checksum="A5B894DA253FDEBA" modified="2018-01-31" version="1">MRIGELSRRTGVSQRSLRYYEEQGLLTPTRLPNGYRDYDERTVTTVRRIQILLSAGLGTSAVAEILPCAVDDTVVLSGKCPELIDGLAKERRRINAAIDDLIAARDILDSLIGRPLLAQAVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR1</accession>
    <name>A0A2G1XMR1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_07005</name>
        <name evidence="6" type="ORF">CYQ11_27160</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52518">
        <property type="protein sequence ID" value="PHQ52518"/>
        <property type="gene ID" value="BLA24_07005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16054">
        <property type="protein sequence ID" value="PPT16054"/>
        <property type="gene ID" value="CYQ11_27160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="202"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="345" mass="35026" checksum="9726EB270236531C" modified="2018-01-31" version="1">MRFALDAEQRAFGRVLDRMLSAAGTPAAVRAWARGEHGPGLALWERVAAAGVFQPAAPEAYGGAGLLPVELSVAFVELGRHGVPGPLVETVAALVLLGRLAGAGEAAPAEEWGPRACAGRARLTLAAAGGPYALDADVADAVFVVDGPQGAAGGAGRHTLRLAPGHGPVQPSLDPARRLARPHGDGELLATGPAVRDAAAHAAEWAALATAAQALGVGHALLDRTVAYARRRTQFGAAIGSFQAVKHRLADTLVDLEFARPLLLGAAVALAGDDPGTSAAVAAAKAAACDAAYAAARTALQVHGAIGYTAEYDLSLWIGKARALRSAWGTPRECRAKALGLYDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMS8</accession>
    <name>A0A2G1XMS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TolB-like translocation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07205</name>
        <name evidence="4" type="ORF">CYQ11_27360</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52552">
        <property type="protein sequence ID" value="PHQ52552"/>
        <property type="gene ID" value="BLA24_07205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16090">
        <property type="protein sequence ID" value="PPT16090"/>
        <property type="gene ID" value="CYQ11_27360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304743" evidence="2">
        <location>
            <begin position="35"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="347" mass="37660" checksum="4577C56D1911A7A0" modified="2018-01-31" version="1">MNRENVLSRRNRLLVLLAAVLVLAAVAVGAVLHAAGRAAQKDQEQAGGPPVRSGKVTLDAPGRGVFRNMAWGPHRDEIASVAADDPTGPRTASGVRCLRFHTAGGTGVCLQAVRGGLREAYRAVVLDAHLRELRHYDLAGVPTRARVSPDGRSVAWTVFVSGDSYAGTAFSTRTSVVDTRTWTVDRDLEDYQVFVDDRPYKRADINVWGVTFADDTRFYATVATAGKTYLVSGDRTARTLRALHENVECPSLSPDGTRIAYKKRVEGASSDAPWRLYVLDLRTLRESATAERRNVDDQAVWRDGHTLVYSLPGDYGSDLWTVPADGSGRPQVAMAAALAPAFTGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMU5</accession>
    <name>A0A2G1XMU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06905</name>
        <name evidence="3" type="ORF">CYQ11_27055</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52501">
        <property type="protein sequence ID" value="PHQ52501"/>
        <property type="gene ID" value="BLA24_06905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16035">
        <property type="protein sequence ID" value="PPT16035"/>
        <property type="gene ID" value="CYQ11_27055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304978" evidence="1">
        <location>
            <begin position="28"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="344" mass="36342" checksum="AAD8E3D5EAC43569" modified="2018-01-31" version="1">MRTAIRTGMTAVAAIAAVAVPAAPAGAEGSPSYGATTGVGVHNAYDTAKYPYFADALDSGAGLLEIDVWTNGFGGGSFRVSHSKPLSNDNNCVNAGSPAALRTGARNQPLSGCLADIRAWHDANPGHRPILLKVEMKDGFNANSGRGPAELDALLSAELGDALYRPGDLMGKHASLDEAVQADGWPSRSALAGKFIVELIPGVVEEGNPLDRLWTDREYATHLRDLAAAGRIGQAAAFPAVHNAAAGDPRTRYADATIRPWFVVFDGDATAYTAGGIDTAWYDRRHYLVVMTDAHKVAPAIDITRPTEAQARERVSLMARSHASFATADWYPLPQVLSTVVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN18</accession>
    <name>A0A2G1XN18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000077">
        <property type="protein sequence ID" value="PHQ52642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52642">
        <property type="protein sequence ID" value="PHQ52642"/>
        <property type="gene ID" value="BLA24_06320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="127" mass="13779" checksum="4232095251BBFBC1" modified="2018-01-31" version="1" fragment="single">MAVELGARGAVVYVTGRTTRERRSEVGRAETVEETAELVTAAGGTGVAVPTDHLEPAAVEALARRVDGEQGRLDVLVNDVWGGEHLIEFGKKVWEADLAKGLRMLRLSIDTHAITSHFLTPLLIRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNB7</accession>
    <name>A0A2G1XNB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05545</name>
        <name evidence="5" type="ORF">CYQ11_02005</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52737">
        <property type="protein sequence ID" value="PHQ52737"/>
        <property type="gene ID" value="BLA24_05545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11832">
        <property type="protein sequence ID" value="PPT11832"/>
        <property type="gene ID" value="CYQ11_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="43005" checksum="23D710F891B0C769" modified="2018-01-31" version="1">MTLDKRLGQRFLPYGANYLDWSDMRELREAIEQGVLFRYQTDGESVASRLERRVAERLGAGHVLAVHNCTEALRLALISTRPRTGDLVHIPAVTFVAVAGAVLSSGLVPVLVDVDESLSLDAALLPPGTERVIVAHMEGTVAPLPQGVPYVVEDCAQALGATFPDGRHAGTAGYAGTFSFHHNKVLTSGEGGLVVTGDPAAWATMRCYHDHGSARVPGRYPTWNPDAHYGENFVTSEGVAAVQFQQFRHLDELLAGLERQHAIAMDALPDRGDLRVLPRATGDVKISLRFRWESRELRDAAVAALTRRGIANWTLDKYLLPEHPVITGRRSLYSDGFPWSLAPDRPLMLSRDGFARTRDLLDRTLCVPLSPELSEPDQVLAVKTLRQVLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW6</accession>
    <name>A0A2G1XNW6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF72 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05200</name>
        <name evidence="2" type="ORF">CYQ11_28330</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52945">
        <property type="protein sequence ID" value="PHQ52945"/>
        <property type="gene ID" value="BLA24_05200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11393">
        <property type="protein sequence ID" value="PPT11393"/>
        <property type="gene ID" value="CYQ11_28330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="28663" checksum="C9E48FA8F0D3775D" modified="2018-01-31" version="1">MPLLVGTSGWQYKDWRGDLYPADLPQRLWLEEYAARFTTVENNNAFYRLPKPETFADWRERTPDGFVMAVKASRYLTHIKRLREPEEPVDRLMRHASGLGERLGPVLLQLPPTLRADAALLDAALACFPAGTRVAVEPRHDSWWTEEIRSVLEDRGAALCWADHDSRPVTPLWRTAGWGYVRFHCGRAQPWPRYGRQALGTWARRVADTWPDDADVYTYFNNDPGGAAVHDAAAFARAAACLGRTVSRTPDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNX2</accession>
    <name>A0A2G1XNX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_04550</name>
        <name evidence="10" type="ORF">CYQ11_28975</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52849">
        <property type="protein sequence ID" value="PHQ52849"/>
        <property type="gene ID" value="BLA24_04550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11494">
        <property type="protein sequence ID" value="PPT11494"/>
        <property type="gene ID" value="CYQ11_28975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="248"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="390" mass="41678" checksum="20CD379E9584FA4E" modified="2018-01-31" version="1">MSTAPSSVLETEHREITEAFMSFVRRELVPLSAELPETWGMPPADLRAHVRKRSARLGFYAGDYPEELGGSGMPFTAVVLLHQAAGRSGCPLAPYALAGSDGPSPLLRQGTPEQVERYLKPLVRGEATRCLALTEPNAGSDAFHLTSTATRQPAGDWVLTGRKTFVSNAGHADFAIVVARAAGGNGEDGPTAFVVDMDHPRLRIGQRYDGMSGEELCELVLDDVRVPAEAVVGGEEGIGAALGHGIDSLSRGRLVVAAMCDGIAEYALELGVAYARERRAFGERIGAYQHVQEHLVGSRAEVEAAKLLTLACARLVDGGVEAPENAALAKLTSSETAVRVVDRSLRVHGATGWVRGHPLEFLYRYVRMMTIIEGTSEIQKVIVARAMGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP00</accession>
    <name>A0A2G1XP00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05170</name>
        <name evidence="3" type="ORF">CYQ11_28360</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52940">
        <property type="protein sequence ID" value="PHQ52940"/>
        <property type="gene ID" value="BLA24_05170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11398">
        <property type="protein sequence ID" value="PPT11398"/>
        <property type="gene ID" value="CYQ11_28360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="407" mass="45464" checksum="63B9AA3C6186112E" modified="2018-01-31" version="1">MPYFTDPLTTLVRRGREPAFVQAVRSTLASVIAYVVALWLSNEPAPLTAPLTALLVVQVTLYSTLTTGIRRVNSVVAGVLIAIGFSALVGLTWWSLGLIILASLVIGRFVRVGEFVPEVAISAMLVLGVTRVAETAWDRVLETLIGAVVGLMFDLLFVPPVWVQPAGDAIEDLARRMRRLLQHIGETVTGHTPVAEAAARLHEARRLDNDITQVDASLRQAEDSLKLNPRVKEGLLFRVVLRTGLDTLEIAAVVLRVICRTLTDLAKERTEETLFAPEVAVALEEVFRHLATAIESFAVLITTQVTANAEEAEDRLLKELAEGRASRDRAAHLLLDGVRVHPRQWQLHGALLAEVDRILDELDVEKRTERLAEELDRHSREQIERHPLRRMRRRLRKSRYGWRSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP50</accession>
    <name>A0A2G1XP50_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_04125</name>
        <name evidence="7" type="ORF">CYQ11_14135</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53012">
        <property type="protein sequence ID" value="PHQ53012"/>
        <property type="gene ID" value="BLA24_04125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16551">
        <property type="protein sequence ID" value="PPT16551"/>
        <property type="gene ID" value="CYQ11_14135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="390" mass="41496" checksum="D6467EC9CDA4BAE7" modified="2018-01-31" version="1">MSGRAQLMWDEAVTGYNFGPGHPMDPVRLSLTMRLVEAFGLDRALRTVAAPAAGESTLRLVHRPDYISAVRRASADPRSADGSYGLGTPDDPAFAGMHEAAALIAGQSVAAAEAIWRGEVLHAVNFAGGLHHAMPGGASGFCVYNDPALAIARLLELGAERVAYVDVDVHHGDGVQAAFWEDPRVLTVSLHEHPRTLFPQTGWPEETGAAGAEGGAVNVALPAGTGDAGWLRAFHAVVPELLAAFRPQVLVTQHGADTHFEDPLAHLAVSLDAQRLVAEACHALAHEHAEGRWLALGGGGYAVADVVPRSWAHLVAIAAGQPVEPGSPMPEEWRSEVYRRTRELGPLRMTDGVEPEWRDFSSGGYDPADRLDQAILATRRSVFPAHGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPP2</accession>
    <name>A0A2G1XPP2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="15" type="ORF">BLA24_02385</name>
        <name evidence="16" type="ORF">CYQ11_04750</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53204">
        <property type="protein sequence ID" value="PHQ53204"/>
        <property type="gene ID" value="BLA24_02385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12296">
        <property type="protein sequence ID" value="PPT12296"/>
        <property type="gene ID" value="CYQ11_04750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="308"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ53204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="384" mass="38631" checksum="49D826E312BF1F77" modified="2018-01-31" version="1">MATATEADAMRRAIELASRALGSTSPNPVVGCVVLDAVGRVAGEGWHRRAGESHAEVDALRAAADAGHDVRGGTAVVTLEPCNHTGRTGPCSQALVEAGIARVVYAVADPNPTATGGAATLAAAGVETEGGLLADEAAAGNAAWLTSVLRGRPFVVWKYAATLDGRTAAADGTSRWITSAESRADVHRLRAEADAVVVGSGTLRADDPHLAVRGQPTPGRPVTQPLRVVVDTHATITPGARVLDDAAPTLVVVGEEADTRHLPGVDTVRLPGEKATGPTGDGKAGIAVHALLGALHDRGVRSVLLEGGATLAGAFLAAGAVDRVIGYLAPALLGAGPSALGDAGIATIAQVLRLDVTDVARLGPDLRITATPTVPATAPATEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT0</accession>
    <name>A0A2G1XPT0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">BLA24_02775</name>
        <name evidence="11" type="ORF">CYQ11_05070</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53255">
        <property type="protein sequence ID" value="PHQ53255"/>
        <property type="gene ID" value="BLA24_02775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12347">
        <property type="protein sequence ID" value="PPT12347"/>
        <property type="gene ID" value="CYQ11_05070"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="363" mass="38459" checksum="4E166E8CDFA96F86" modified="2018-01-31" version="1">MTDAPTRIQVAGSAGTAPYEVLVGRRLLGELPGLIGDKAKRVAVLHPEALAETGEVLRQDLAEQGYEAIAIQLPNAEESKTVEVAAYCWKALGQTNFTRTDVIVGVGGGATTDVAGFVAATWLRGVRWIAVPTTVLGMVDAAVGGKTGINTAEGKNLVGAFHPPAGVLCDLAALESLPVNDYVSGLAEIIKAGFIADPAILELIEADPQAARDPKGPHTAELIERAIRVKAEVVSSDLKESGLREILNYGHTLAHAIEKNERYNWRHGAAVSVGMVFAAELGRIAGRLDDATADRHRAVLTSVGLPVTYRGDQWPKLLETMKVDKKTRGDRLRFIVLDGLAKPTVLEGPDPAMLLAAHAEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQF4</accession>
    <name>A0A2G1XQF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00600</name>
        <name evidence="4" type="ORF">CYQ11_07610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53466">
        <property type="protein sequence ID" value="PHQ53466"/>
        <property type="gene ID" value="BLA24_00600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12771">
        <property type="protein sequence ID" value="PPT12771"/>
        <property type="gene ID" value="CYQ11_07610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="425" mass="46028" checksum="3A3EC3119B177F34" modified="2018-01-31" version="1">MDRCVVLVDAGYLLGAAASLLAGEPARSRITVDHSTLIQGLRERAESETQRPLLRIYWFDGAPDRVPQPEHRRLRVMPRVTVRLGALTRSDGRWAQKGVDAAMHTELTELARNRACSDIVLVTGDGDLLPGLMSAKEHGVAVHLWAVQAADGDYNQSEDLVAEADERRVLDRTWITRAVRAKDLAGACAPQPADRPEIAAILSAPLPETAAAAAAAANRQPEPATTERNGTRPAAVAALTTAERGADGPATRGVPTPKDLAGLGRGPAQQSAGTAQTVQPATPNATLRWSSDKGWVERGAGNGLGEPPETACLPMLAQLTSAEQRWADREEDITTVGGDPFEVGQVFARRWAERLTDSVHLQHLSTEYPRIPHRIDGELLRYAARFGLLAHKDDQIDEHDRYAIRAGFWREIDARTAAEHTQAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQP3</accession>
    <name>A0A2G1XQP3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00950</name>
        <name evidence="6" type="ORF">CYQ11_07960</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53530">
        <property type="protein sequence ID" value="PHQ53530"/>
        <property type="gene ID" value="BLA24_00950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12835">
        <property type="protein sequence ID" value="PPT12835"/>
        <property type="gene ID" value="CYQ11_07960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="32538" checksum="7EFFFF8C298EBC41" modified="2018-01-31" version="1">MGLTIGVDIGGTKIAAGVVDEEGSILATCKVPTPDTPEGVVDAIADAVRTVSEGFDVEAVGIGAAGYVDDKRATVLFAPNINWRHEALKDKVEQRVGLPVVVENDANAAAWGEYRFGAGQGHDDVICITLGTGLGGGIIIGNKLRRGRFGVAAEFGHIRVVPDGLLCGCGSQGCWEQYASGRALVRYAKQRAHATPENAEILLSLGDGTPEGIEGKHISDAARQGDPVAIDSFRELARWAGAGLADLASLFDPSAFIVGGGVSDEGDLVLDPIRKSFRRWLVGGQWRPHAQVLAAQLGGKAGLVGAADLARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQQ0</accession>
    <name>A0A2G1XQQ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01025</name>
        <name evidence="3" type="ORF">CYQ11_08035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53543">
        <property type="protein sequence ID" value="PHQ53543"/>
        <property type="gene ID" value="BLA24_01025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12848">
        <property type="protein sequence ID" value="PPT12848"/>
        <property type="gene ID" value="CYQ11_08035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="38"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="452" mass="47561" checksum="E94DFA0B164BC558" modified="2018-01-31" version="1">MSVATLAADQSVCPPLPVLGRDVRVPLVTGGEVTYAALDYAASAPALQRVWDDVAAYAPYYGSVHRGAGYLSQLSTELFENSRAEVAAFLGCRPGDQVVFTRSTTDSLNLLAAVLPAGCRVFVFETEHHAALLPWPAGHVTVLDAPRSPRQAVEILERALADRDPHGPALVCVTGASNVTGELWPVRELAAAAHAHGARIVVDAAQLAPHHPVDIAACDVDWVAFSGHKLYAPFGSGVLAGRADWLTRARPYLAGGGASRTVARGGDGGLDVEWHTTAARHEAGSPNVIGAYAIAAACKALTEAGFERLVEREQRLVARVREGLAGVPGVRVLSLFGDDAPRVGVLSFVVDGWNSSHFAAALSAEYGIGVRDGLFCAHPLVRVLLGGERDEPGECGAPDGERSLNAVRVSFGAGTPDEHVERFVRAVGELVANGARWLYRTEDGRCVPDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9M8</accession>
    <name>A0A2G1X9M8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_30650</name>
        <name evidence="6" type="ORF">CYQ11_23745</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47869">
        <property type="protein sequence ID" value="PHQ47869"/>
        <property type="gene ID" value="BLA24_30650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15494">
        <property type="protein sequence ID" value="PPT15494"/>
        <property type="gene ID" value="CYQ11_23745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ47869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23873" checksum="E484B31FDC982778" modified="2018-01-31" version="1">MRVLVVEDEQLLADAVATGLRREAMAVDVVYDGAAALERIAVNDYDVIVLDRDLPAVHGDDVCRKVVELGIPTRVLMLTASGDVSDRVEGLEIGADDYLPKPFAFSELTARVRALGRRTTVALPPVLERAGIKLDPNRREVFRDGREVQLAPKEFAVLEVLMRSEGAVVSAEQLLEKAWDENTDPFTNVVRVTVMTLRRKLGEPPVIVTVPGSGYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Z7</accession>
    <name>A0A2G1X9Z7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2637 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31830</name>
        <name evidence="4" type="ORF">CYQ11_24885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48043">
        <property type="protein sequence ID" value="PHQ48043"/>
        <property type="gene ID" value="BLA24_31830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15669">
        <property type="protein sequence ID" value="PPT15669"/>
        <property type="gene ID" value="CYQ11_24885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="353" mass="38918" checksum="1DD65A702C4D94C2" modified="2018-01-31" version="1">MRVTDIPLNWVLPSAVALIGAVVAVTVYARGRRTGPEDTAAGTDSWERNEERRRRKEAIYGSASYVLLFCCAAVAAALSFHGLVGFGQQNLGLTDGWEYLVPFGLDGAAMFCSVLAVREASHGDAALGSRMLVWTFAGAAAWFNWVHAPRGLDHAGAPQFFAGMSLSAAVLFDRALKQTRRAALREQGLVPRPLPQIRMVRWLRAPRETFGAWSLMLLEGVRSLDEAVEEVREDKRQRAQHRMRRREAGKLERARLKAYNRQHRVWSRPRGGRQVEVTAPTPVPAAAQPAQIGSQGGPEPSIVEHGQLPVRSRPLQAVGRPDPIDLTAEDDTQAIPRLDSLEAKLAQIERQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA25</accession>
    <name>A0A2G1XA25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32015</name>
        <name evidence="4" type="ORF">CYQ11_25070</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48072">
        <property type="protein sequence ID" value="PHQ48072"/>
        <property type="gene ID" value="BLA24_32015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15698">
        <property type="protein sequence ID" value="PPT15698"/>
        <property type="gene ID" value="CYQ11_25070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="58"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="463"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="564" mass="61991" checksum="8A537A6DE7CC3B45" modified="2018-01-31" version="1">MTTTSATGTTGPAEAFRAARDFLLAHREDYARAYEGFTWPRPAEFNWAIDWFDTIADGNDRTALWIVEEDGTEQRISFDALRRRSDRVANWLRARGVRAGDRLVVMLGNQTELWETALAAMKLRAVVIPATPLLGPADLADRLARGRARHVVVRAEDTAKFTDVPGDYTRIAVGGTPGGDWLAYEDSAHADEAFTPDGPTRADEPLLLYFTSGTTAQPKLVEHTHTSYPVGHLTTMYWIGLRPGDVHLNISSPGWAKHAWSNLFAPWNAEATVFVHNYTRFDAARLMAEMDRCGVTSFCAPPTVWRMLIQADLGALRRPPREAVAAGEPLNPEVIEAVRRAWGLTIRDGFGQTETSVQVANPPGQALKTGSMGRPSPGFTVALLDPHTGEPADEGEIALDLSERPVGLMTGYAGDPERTAEVMAGGYYRTGDIGSRDADGYITYVGRADDVFKSSDYKISPFELESALLEHEAVVEAAVVPAPDPLRLSVPKAYVVLAEGWEPGPDTAKALFAHSRAVLAPYKRIRRLEFADLPKTVSGKIRRVELRERTARGGGVEYREEDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA81</accession>
    <name>A0A2G1XA81_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_32415</name>
        <name evidence="9" type="ORF">CYQ11_25465</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48136">
        <property type="protein sequence ID" value="PHQ48136"/>
        <property type="gene ID" value="BLA24_32415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15762">
        <property type="protein sequence ID" value="PPT15762"/>
        <property type="gene ID" value="CYQ11_25465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="67"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="31460" checksum="20EAD847F6350609" modified="2018-01-31" version="1">MTGTALYDVPGPQARRRHRLYGVLATVVILGILAWVLYLLFDTEQFTATKWTPFAYKGIQEMLLRGLGNTLKAFAYAAVLSLVLGGVLACGRLSEHGPVRWAATLVVEFFRAMPVLVMIFFVFVALKVQPLPALVTGLTLYNGSVLAEVFRTGVNSVERGQREAAYSLGMNKTQVMSHVLVPQALRAMLPTIISQLVVALKDTSLGFLITYEEFLHAGKLIASNLDYDLPFIPVVMVISPVYIGMCMLLSWFATWVAKQQRRSLKTEAVQVAPAEPGTLMPGTTAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAU6</accession>
    <name>A0A2G1XAU6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_30645</name>
        <name evidence="7" type="ORF">CYQ11_23740</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48332">
        <property type="protein sequence ID" value="PHQ48332"/>
        <property type="gene ID" value="BLA24_30645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16756">
        <property type="protein sequence ID" value="PPT16756"/>
        <property type="gene ID" value="CYQ11_23740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="27719" checksum="AD7A98113546A676" modified="2018-01-31" version="1">MKAELKAELLAVALEAAERAGTLLRDGRPADLGVAATKTSPIDVVTEMDIAAEKLITGFLAERRPADGLLGEEGASSEGSSGVRWVIDPIDGTVNYLYGLPSWAVSIAAEIDGEAVVGVVAAPMRGETYRAVLGEGAFAGDRRLAVRPTPALEQALIGTGFGYLTARRAAQAEVLRSLLPEVRDIRRGGSAAIDLCDVACGRLDGYYERGLNPWDFAAGALIAREAGALTGGRPGEPASGELTVAAPQGLFAPLQARLEDLGAWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAZ1</accession>
    <name>A0A2G1XAZ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL family lipase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32450</name>
        <name evidence="4" type="ORF">CYQ11_25500</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48371">
        <property type="protein sequence ID" value="PHQ48371"/>
        <property type="gene ID" value="BLA24_32450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16797">
        <property type="protein sequence ID" value="PPT16797"/>
        <property type="gene ID" value="CYQ11_25500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304545" evidence="1">
        <location>
            <begin position="32"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="296" mass="30186" checksum="83EDEE72CF5CFA1A" modified="2018-01-31" version="1">MTKRSGRYGKALAALGAASALAAGAAAPAAAATGQSAEQSGGARYVALGDSYTSAPGVPTQVDENCARSSVNYPSLVAAKLNQKSFKDVSCSGAKTDEMWREQGTNAPQLNALGKNTRLVTLGIGGNDIGFSGIIGTCAQLSASDPAGAPCQKQFTAGGTDQLTARIAEAAPKVASVLKAVHQRAPHARVAVVGYPAIMPDSGVGCFPAVPIAAGDAAYLRDTEKHLNDMLRTEARKAHVGYVDTYGPTVGHDVCTPTADRWIEGASPENPAAPFHPNAKGEQAMAGAVLGTLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB26</accession>
    <name>A0A2G1XB26_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent ferric siderophore reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28945</name>
        <name evidence="3" type="ORF">CYQ11_06530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48412">
        <property type="protein sequence ID" value="PHQ48412"/>
        <property type="gene ID" value="BLA24_28945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12593">
        <property type="protein sequence ID" value="PPT12593"/>
        <property type="gene ID" value="CYQ11_06530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="30366" checksum="B7EAE7A47791BDD9" modified="2018-01-31" version="1">MPDAPPPPPPYQWFDLHVLRTERVSPSLLRVTFGGERLGDMVTDGRDQRFKLFLPRPGQDAPVLPDDRGISWYAQWRAQDPAVRAVMRSYTIRELRHDPAELDVDFVQHGEGHDGHGGPASHWSRTARPGDRVAVLGPVAEDNGGADFQPPAGTDWVLITADESALPAVAGILAWLPAGTPARVWVEVAHPEDVQDLPTKADAEVTWLVGGATATLDAVRAADLPAGTPYAWVAGESGTVRAVRRHLVSERGFDRRTVTFTGYWRRGATEEQLLAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB41</accession>
    <name>A0A2G1XB41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29325</name>
        <name evidence="5" type="ORF">CYQ11_06150</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48467">
        <property type="protein sequence ID" value="PHQ48467"/>
        <property type="gene ID" value="BLA24_29325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12535">
        <property type="protein sequence ID" value="PPT12535"/>
        <property type="gene ID" value="CYQ11_06150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="26038" checksum="DD4D5A9943893142" modified="2018-01-31" version="1">MAASGRSAGPEVIWARPERSARGPRPSHTRADIAAAAVRIADAEGLDAVSMRRVAAEIGCGTMSLYNYVPRKEDLYELMFDAAVAEYDLSEPPTGDWRADTLALARQTRALMHRHPWLPRLLAPEYGFSPHSLRYLEYALWALDPLDVGGGTKMELLSMLSAVVAAYVTHELSAAERARSSPFAPGQEQAARQEHLVRQLAGGAYPRLAAAFAAPSEVPDGEALFERAVERVLAGFAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB48</accession>
    <name>A0A2G1XB48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29260</name>
        <name evidence="2" type="ORF">CYQ11_06215</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48458">
        <property type="protein sequence ID" value="PHQ48458"/>
        <property type="gene ID" value="BLA24_29260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12547">
        <property type="protein sequence ID" value="PPT12547"/>
        <property type="gene ID" value="CYQ11_06215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="84" mass="8984" checksum="AA8177A4EE2846B0" modified="2018-01-31" version="1">MPENESQALVIVDAEDNYYVLPREAVEMARAAPEARAVIEEHLGGSEKVPLAGGYAFVGVLTLPGEAEMAHYTPEVAWPVATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB85</accession>
    <name>A0A2G1XB85_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUDIX domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29410</name>
        <name evidence="7" type="ORF">CYQ11_06065</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48482">
        <property type="protein sequence ID" value="PHQ48482"/>
        <property type="gene ID" value="BLA24_29410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12520">
        <property type="protein sequence ID" value="PPT12520"/>
        <property type="gene ID" value="CYQ11_06065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024195">
        <property type="entry name" value="NUDIX_hydrolase_YfcD_pred"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017340">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017340-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="20163" checksum="4DB584CA0971E371" modified="2018-01-31" version="1">MSDQEPLAADEVLDVVDAHDRVVGQAPRGEAYARGLRHRCVFVQARDARGRIFVHRRTDRKLVFPSRYDMFVGGVVGAGETYDGAALREAEEELGVSGLPAPTPLFRFLYETDEHSWWSAVYEVRCDLPVNPQAEEVAWYAFLSEEEVEARLEQWEWVPDGLAAHRLLREHRRNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBE1</accession>
    <name>A0A2G1XBE1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29905</name>
        <name evidence="4" type="ORF">CYQ11_05565</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48564">
        <property type="protein sequence ID" value="PHQ48564"/>
        <property type="gene ID" value="BLA24_29905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12434">
        <property type="protein sequence ID" value="PPT12434"/>
        <property type="gene ID" value="CYQ11_05565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="20179" checksum="6652D8035C18E232" modified="2018-01-31" version="1">MRWKNLSELTVYENRWFQVNLADVELPDGRHLDHFLIRLRPVAVATVVNAANEVLLLWRHRFITDNWGWELAAGVVEDGEDVAYAAAREMEEETGWRPGPLRHLMSVEPSNGLTDARHHIYWSDEAEYIGDPEDAFESDRREWVPLKLVPDLIARGEVPAANMAAALLLLHHIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBF2</accession>
    <name>A0A2G1XBF2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29715</name>
        <name evidence="3" type="ORF">CYQ11_05760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48531">
        <property type="protein sequence ID" value="PHQ48531"/>
        <property type="gene ID" value="BLA24_29715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12469">
        <property type="protein sequence ID" value="PPT12469"/>
        <property type="gene ID" value="CYQ11_05760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="155"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="324" mass="35749" checksum="961F9C7881C13D8A" modified="2018-01-31" version="1">MAIAKAERLMNLALCLLSTRRPLTKGELRASIEAYIEAATAGGEPGKDDAFNRMFERDKEDLRELGLIIETVEGVDGETGYLARRDSNRLPPITLDVEEAAALGLAAKVWQQARLAGAASGALQKLRAAGMPLAEDPYGATSALETRIPVHEAAFEPLMLAARDRRPVVFDYRKASAAHPEQRRVEPWALECWRGHWYLAGWDRDRQAERVFRLSRITGKVRSRALAFTAPVPDHVTVRETVESWAGETATGTARIRVRTGHGYPLRARALSSRELGDGWDELEIPYGHGLDAWLVEFGPDVIVLGPAELRADVVDRLRAVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBG3</accession>
    <name>A0A2G1XBG3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29915</name>
        <name evidence="5" type="ORF">CYQ11_05555</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48566">
        <property type="protein sequence ID" value="PHQ48566"/>
        <property type="gene ID" value="BLA24_29915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12432">
        <property type="protein sequence ID" value="PPT12432"/>
        <property type="gene ID" value="CYQ11_05555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="199"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="31727" checksum="107B4AC240847C73" modified="2018-01-31" version="1">MSERHDVTDIAVDLARVGVVGCGQMGAGIAEVCARAGLDVKVAETTGEALELGRTRLTNSLGKAAERGKITEGERDATLGRLSFTTDLGEFADRDLVIEAVVENEQVKTEIFQILDQVVTRPDAILASNTSSIPLVKLAVATSRPDRVIGIHFFNPAPVQKLVELIPALTTSDETIKRAEALVGKILGKHAIRAQDRSGFVVNALLIPYLLSAIRMFESGMASREDIDNGMELGCAHPMGPLKLSDLIGLDTVASVAQSMYEEYKEPLYAAPPLLQRMVDAGRMGRKSGAGFYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBM5</accession>
    <name>A0A2G1XBM5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28485</name>
        <name evidence="3" type="ORF">CYQ11_06985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48654">
        <property type="protein sequence ID" value="PHQ48654"/>
        <property type="gene ID" value="BLA24_28485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12666">
        <property type="protein sequence ID" value="PPT12666"/>
        <property type="gene ID" value="CYQ11_06985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="17224" checksum="39EA4D301000C737" modified="2018-01-31" version="1">MKLDSMYQDVILDHYKNPHGRGLRDGDAEVHHVNPTCGDEITLRVRMAGETVEDVSYEGQGCSISQASASVLNELLVGKDLGEARRIQETFLELMQSKGRIEPDDAMEEVLEDAVAFAGVSKYPARVKCALLSWMAWKDATAQALGEGPESTVRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBM7</accession>
    <name>A0A2G1XBM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_28500</name>
        <name evidence="11" type="ORF">CYQ11_06970</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48657">
        <property type="protein sequence ID" value="PHQ48657"/>
        <property type="gene ID" value="BLA24_28500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12663">
        <property type="protein sequence ID" value="PPT12663"/>
        <property type="gene ID" value="CYQ11_06970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304556" evidence="7">
        <location>
            <begin position="27"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="162"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="41041" checksum="B48E847A2F97B33D" modified="2018-01-31" version="1">MKPPRYRLCAAALMLALPLAAAPAVAAEPAPGPDSTARLAPLRQTSGQPVPGHYIVTLRKGSSPRTLTSRLGVVPDFVYTHALTGFAATLTPEQLEAVRGASDVEAVEEDAVYSQADEDDAPATRTRAPTQSWGLDRVDQHRLPLDGQFSEAATGEGGTAYIVDTGIDYGHPEFGGRARNGTDLVTSGGDGKDCPSGSGHGTHVAGVVGGATYGVARKATLVSVRVLDCTGRTTAARVAAAFEYVAANAPAASVVNASLSGPPSRAIDTAVGNVAAKGVLPVVAAGNNNDSACDHSPSGALAALAVGATNQRDQMTDFSNSGPCARILAPGEDIVSAAPGGGTATKSGTSQASPYVTGVATLYKARTPSATSDAVIKWLVEQSTKDVVTDLKAGTPNRLLFTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBP9</accession>
    <name>A0A2G1XBP9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="11" type="ORF">BLA24_28345</name>
        <name evidence="12" type="ORF">CYQ11_07125</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48631">
        <property type="protein sequence ID" value="PHQ48631"/>
        <property type="gene ID" value="BLA24_28345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12690">
        <property type="protein sequence ID" value="PPT12690"/>
        <property type="gene ID" value="CYQ11_07125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="10">
        <location>
            <begin position="259"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="666" mass="74490" checksum="48FBDA38D809D4EC" modified="2018-01-31" version="1">MADPSSYRPKPGQIPDSPGVYRFRDEHGRVIYVGKAKSLRQRLSSYFQDLAGLHPRTRTMVTTAASVEWTVVSTEVEALQLEYSWIKEYDPRFNVKYRDDKSYPSLAVTLNEEFPRVQVMRGPKKKGVRYFGPYAHAWAIRETVDLMLRVFPVRTCSAGVFKRSAQIGRPCLLGYIGKCSAPCVGRVTPEEHRELAEEFCDFMAGRTGAYIRRLEQRMHDAAEEMEYERAARLRDDIEALRRAMEKNAVVLADATDADLIAVAEDELEAAVQIFHVRGGRVRGQRGWVTDKVEAVDTAGLVEHALQQLYGEESGDAVPKEVLVPALPQPAEPVAQWLTERRGARVDLRIPQRGDKRDLMATVQRNAQQALVLHKTRRASDLTTRSRALEEIAGALGLDSAPLRIECFDISHLQGQDVVASMVVFEDGLARKSEYRRFQIKGRVGDTQVWHGTGQDDVRSMHEVVSRRFRRYLQEKQKTGEWTEEALDGEVSAEGDDRPKRFAYPPQLVVVDGGKPQVAAAQRALDELGVTDVAVCGLAKRLEEVWLPEEDDPVVLPRTSEGLYLLQRVRDEAHRFAIAYQRGKRTKTMKAGPLDTVPGLGSTRKQALLKHFGSVKRLRAATVEQICETPGIGRKTAETIVAALARAAPPAPAVNMATGEIMDDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBV2</accession>
    <name>A0A2G1XBV2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_28545</name>
        <name evidence="7" type="ORF">CYQ11_06925</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48734">
        <property type="protein sequence ID" value="PHQ48734"/>
        <property type="gene ID" value="BLA24_28545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16394">
        <property type="protein sequence ID" value="PPT16394"/>
        <property type="gene ID" value="CYQ11_06925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="224" mass="23978" checksum="3D57E9C8E5C4865A" modified="2018-01-31" version="1">MTAAPPPVRIVLADDERMVRTALRAILGAEPDLQVVGEAATGAEAVSLVRELRPDIVLMDVRMPEVDGIRATERIVAGMAEPPRVIVVTTFENDAYVYDALRAGACGFLLKRAGADELVQAVRMVAGSDSLLFPSAVRALAAAYGQERASRAEAERLRARLSEREAEVLRLMTRGLSNAEIAQRMALGAATVKTHVAGVLAKLGVRDRTQAVIAAYECGFVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBX0</accession>
    <name>A0A2G1XBX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28825</name>
        <name evidence="4" type="ORF">CYQ11_06640</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48710">
        <property type="protein sequence ID" value="PHQ48710"/>
        <property type="gene ID" value="BLA24_28825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12609">
        <property type="protein sequence ID" value="PPT12609"/>
        <property type="gene ID" value="CYQ11_06640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="24063" checksum="907A2984E67D022B" modified="2018-01-31" version="1">MPYRPERMPAEESLARAAELRERMGRRRTVRQFSPDPVPEQVVKDAIACAATAPSGAHQQPWTFVLVKDPQIRRRIRLAAEEEEHVSYEGRLGEEWLAALRPLGTDEVKPHLTDAPALVVVFQQRYWLGEDGDKRKHYYVDESVGIAVGMLLTALHLSGLAALVHTPSPMRFLSEVLGRPVNEKAFAVIPVGYPAADCQVPDLVRKSLDQVLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY7</accession>
    <name>A0A2G1XBY7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">BLA24_28395</name>
        <name evidence="10" type="ORF">CYQ11_07075</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48728">
        <property type="protein sequence ID" value="PHQ48728"/>
        <property type="gene ID" value="BLA24_28395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16400">
        <property type="protein sequence ID" value="PPT16400"/>
        <property type="gene ID" value="CYQ11_07075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="550" mass="60433" checksum="B95E09A5221841B6" modified="2018-01-31" version="1">MNAEGRGRLDQTPEWHALAKHRDELGEVHLRELFASDPGRAEKFSLSVGDLHLDYSKHLVTDETLRLLRELAASAGVAQLRDAMFRGERINTTEDRAVLHTALRAPESADVEVDGENVVPAVHAVLRKMQVFSDRVRSGDWKGHTGKPIKNVVNIGIGGSDLGPAMAYEALRAYTARDLTFRFVSNVDGADLHEALHDLDAEETLFIVASKTFTTIETITNATSARNWLLTELRAGEEAVAKHFVALSTNEEKVAAFGIDTANMFEFWDWVGGRYSFDSAIGLSLMIAIGPDRFREMLAGFHLVDEHFRTAPPEENAPLLLGLLGIWYGNFHDAQSHAVLPYSHYLSKFAAYLQQLDMESNGKSVDREGRPVSWQTGPVVWGTPGTNGQHAYYQLIHQGTKLIPADLLGFAKPVDDLQPGLVAQHDLLMANLFAQGQALAFGKTPEEVAAEGVPAELVPHKTFRGNHPTTTILASELSPSVLGQLIALYEHKVFVQGAVWNIDSFDQWGVELGKVLAKRVEPALTEGAEVPGLDASTAALVSRYRELRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC94</accession>
    <name>A0A2G1XC94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_27525</name>
        <name evidence="10" type="ORF">CYQ11_18120</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48821">
        <property type="protein sequence ID" value="PHQ48821"/>
        <property type="gene ID" value="BLA24_27525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14533">
        <property type="protein sequence ID" value="PPT14533"/>
        <property type="gene ID" value="CYQ11_18120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="389" mass="41371" checksum="C135659ABC0BF60D" modified="2018-01-31" version="1">MNAVSTLTEPPEHRALRTAVAALGRRYGRAYFASVVREGAQTDELWAEAGKLGYLGVNLPAEYGGGGGGITELAIVLEELGAAGCPLLLLVVSPAICGTVIARFGTDEQKRTWLPGLAAGTLKMAFGITEPDAGSNSHRLTTTARRDGDDWLLTGRKVFISGVDTADATLVVGRTEDSRTGRLKPCLFVVGRDAPGFSYRRIPMEVSAPEKQFELVLDDVRLPSGALVGDEDAGLLQLFAGLNPERVMTAAFALGMGRYALDRAVDYARTRRVWDEPIGAHQAVAHPLARSHIEIELARLMTYRAAHLYDAGDDAGAGEAANMAKYAAGEAAVHAVDHAVHTLGGNGLTTEYGLASLITAARVARVAPVSREMILNYVSHHTLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF3</accession>
    <name>A0A2G1XDF3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">BLA24_24480</name>
        <name evidence="13" type="ORF">CYQ11_21590</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49225">
        <property type="protein sequence ID" value="PHQ49225"/>
        <property type="gene ID" value="BLA24_24480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15124">
        <property type="protein sequence ID" value="PPT15124"/>
        <property type="gene ID" value="CYQ11_21590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="303"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="421"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="433"/>
            <end position="438"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="680" mass="73219" checksum="D34ECAEDB3C98C0F" modified="2018-01-31" version="1">MSDTTDLMGVNAGAAGNASAPATDAPAAPATGAATAPKRRRSGTGLDAMVLAELQQLASSLGIKGTARMRKGQLIEVIKERQAGGSAAPAKAEAAPAAAETKPKRRATSRTRTGDAAAEKAADKAGQQQIEIPGQPGSDEAPAGERRRRRATAPAGSPEAPAAEPARAETKTEVRTEERAEAKAEAAVDTAEGKAAKGGERQDRGERGQKGERRERGERGERGQRDRDRDRDRDRRGGRDGDAGQKGDRQQRGDRGPQGGGPQDDDDFEGGRRGRRGRYRDRRGRRGREDFAGEPQVSDDDVLIPVAGILDILDNYAFIRTSGYLPGPNDVYVSLAQVRKNGLRKGDHVTGAVRQPKDGERREKFNALVRLDSVNGMAPETGRGRPEFGKLTPLYPQDRLRLETDPGVLTTRIIDLVAPIGKGQRGLIVAPPKTGKTMIMQAIANAITTNNPECHLMVVLVDERPEEVTDMQRSVKGEVISSTFDRPAEDHTTVAELAIERAKRLVELGHDVVVLLDSITRLGRAYNLAAPASGRILSGGVDSTALYPPKKFFGAARNIEDGGSLTILATALVETGSRMDEVIFEEFKGTGNMELKLDRKLADKRIFPAVDVDPSGTRKEEILLGSEELAIVWKLRRVLHALDSQQAIELLLDKMKQTKSNAEFLMQIAKTTPSPGNGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDH5</accession>
    <name>A0A2G1XDH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24805</name>
        <name evidence="2" type="ORF">CYQ11_21265</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49282">
        <property type="protein sequence ID" value="PHQ49282"/>
        <property type="gene ID" value="BLA24_24805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15067">
        <property type="protein sequence ID" value="PPT15067"/>
        <property type="gene ID" value="CYQ11_21265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="138" mass="14419" checksum="1208423CCEF267E0" modified="2018-01-31" version="1">MSPIAGEPGTTQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDEIEDLRIAVDEACAILLQQAVPGSVLSCVFRLVGDALRVTVSAPTTDGRAPERDTFAWTVLSALAGEVDSDVADDRTVSISLHKKRGAGPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDR9</accession>
    <name>A0A2G1XDR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3117 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25370</name>
        <name evidence="2" type="ORF">CYQ11_20705</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009997451.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49380">
        <property type="protein sequence ID" value="PHQ49380"/>
        <property type="gene ID" value="BLA24_25370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14971">
        <property type="protein sequence ID" value="PPT14971"/>
        <property type="gene ID" value="CYQ11_20705"/>
    </dbReference>
    <dbReference type="GeneID" id="61489455"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021465">
        <property type="entry name" value="DUF3117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11314">
        <property type="entry name" value="DUF3117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="55" mass="5716" checksum="9A970F631BE97662" modified="2018-01-31" version="1">MAAMKPRTGDGPLEVTKEGRGIVMRVPLEGGGRLVVELTPDEAEALGDALKKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDT1</accession>
    <name>A0A2G1XDT1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25410</name>
        <name evidence="4" type="ORF">CYQ11_20665</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49386">
        <property type="protein sequence ID" value="PHQ49386"/>
        <property type="gene ID" value="BLA24_25410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14964">
        <property type="protein sequence ID" value="PPT14964"/>
        <property type="gene ID" value="CYQ11_20665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304593" evidence="2">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="134" mass="12689" checksum="E28BC746C3891F79" modified="2018-01-31" version="1">MSLPLTRRIARAALLVAAAAPIVGAAAGSASAADLVKAPDLGGLSAVDSANLGNNVDSVSHQAGDVATGVGAKAVHTTTSAVSKAGKEHVPAAQKVTGQLAGSAGQAVGETAKGVTKGGLPTQGLPTPKGLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE11</accession>
    <name>A0A2G1XE11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49466">
        <property type="protein sequence ID" value="PHQ49466"/>
        <property type="gene ID" value="BLA24_25845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013544914" evidence="2">
        <location>
            <begin position="34"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="302" mass="32161" checksum="526124657E9B70D9" modified="2018-01-31" version="1">MVVPNAAARHERLSLTAVGLLVRLLSMPDGAKATIDTVTEQVSEGRRAVAKAFSALEDAGYLRRERGQDPETGLWGTQTHVSDLPMNRIPTVGAPRHRNVGDLPKGDKNQEKNLLPDPSTEAQAEKAPKADAEEDEASGEKNAQTAPADAETGRAATTLAHLGAIDSRLKLSTNEVLRLAPLAAEWLAEGHSTMKITAVLSARLPERVDSAAALVAYRLRNQMPAKPTPKAPPAPDTRDRCDVCRAPFPQGRQGDLCGACREELDRAAAFLAADPELPTTEPAQTDTPASRGRALCRAVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE24</accession>
    <name>A0A2G1XE24_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25920</name>
        <name evidence="3" type="ORF">CYQ11_20150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49478">
        <property type="protein sequence ID" value="PHQ49478"/>
        <property type="gene ID" value="BLA24_25920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14872">
        <property type="protein sequence ID" value="PPT14872"/>
        <property type="gene ID" value="CYQ11_20150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="684"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1365" mass="142108" checksum="5D35330C160E72AA" modified="2018-01-31" version="1">MSAGQIIGRVAVKVSPDTREFRRDAEKQLDRIEQQLDKLKVSTTIDMSGASKEFVEELRKINKRNKQSDARKIRFYTTISTDGMATAVRNAAKELQRRANSQKVDFKVNDLKTTGKVELELDEQSADHVKRKLRDWADDISPLKIKVEPDLANGFGARISARLQVLTRPRTVPIVPDLDNTAVAKVGTALAALSGARVLNNIFERLGRTLRNLDKSVPIIGSLSLAIAGLAGWGLSAASNLAALSSSLASIGATSLLLPGLFGGMAVGLGVTIAAFRDFNKVLPEVKGALSGLQDAISAKFWEQAKKPIQELVDGLLPKFTAGVRQTATELGQFFGAFAKGLQGALDPALNQMFVDLSKSIDIATNGTGAFANIIAVLGKVGTSYLPSLAQWFVDISERFSAFLTKSEGNGKLKGWIDEGIQSLKDLGSVLYNVGGILAGISRAAEAAGGSSLGMMADTLEKIHATVDSEGFQTGLTNVFAAAHTAMNAIATQSGPAVKNLFSELGQLLTELLPQVGEVIGTALDAVASALAQPAVTEGVKAMFSGIQAAVEALAPAMAPLGQALGALMQVIGAFAAMLGPLIAAALVPLANAFTALAPSITPIIQLLGGALTQAIQTLAPVLTQLVPVIGQALNSAFQTLSGVLPTIAEAFGQIVTAMAPVIAQLVSALAPILPIIAQLFAQIFAALAPLVSTLASALAPILPVLSAALQQVLTALQPIIATALQIITAVIQPLLPMLSEVIQSVLPPLADAIQRLLEALQPVFDALLKVVNILMPVLVPVIQFIVELLAKSLVDAVNGVALVFEGLVEIVKGVWDTIVGVLKIAWGLIEGLFTGNFGTLKEGWSQFWSGIWSFVKGIWDTILGAFETFLSIGILGAAGKGLKAIGAAFKSGWQAVKGFGEAAWSAIKSGFSSFGSFLADLGRSMMSGLGSLFSAGWSAIKDVASRAMSALGRAISTGITETIGFVKELPGKAKDALSGLGSTLVDAGKSLIRGLISGISSMFGAVKDKLGDLTSKLTDWKGPAPKDAVLLYDAGRLIIQGLVKGLESEFSSVKEALNELTEKIPNDASQGLKNRINADRTAMLKLAAQWDTGADRLKAARDKLDKMREEAASYAQRVTDRIIDTGDVTKAKSSSFNGITSALQAAIDKAKRFATALKKLKDMGLGQTAMDQIASAGPDAGLAAAESIAAAGKNGIAEVNRLQAELAKYASQAGATASDAMYANGVHIAEGIVKGLQSQQAAIEKQMLQIADSMVAAIKKSLGIHSPSRVFAQLGSYVGQGFAQGIEGESGRVAKAVDAITARPSSADYANAARSASAAIAGGLGPTGGGGVTKVLNYYAAAGSSLSSQEELFAASHRARMVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC8</accession>
    <name>A0A2G1XEC8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 10">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_26590</name>
        <name evidence="14" type="ORF">CYQ11_19045</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 10"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49594">
        <property type="protein sequence ID" value="PHQ49594"/>
        <property type="gene ID" value="BLA24_26590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14687">
        <property type="protein sequence ID" value="PPT14687"/>
        <property type="gene ID" value="CYQ11_19045"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="12">
        <location>
            <begin position="35"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="11">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ49594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="273" mass="28555" checksum="F229730EEE250963" modified="2018-01-31" version="1">MNASVTPDIQADPYAAANDAAARLRELTGAETHDVALVMGSGWVPATEALGTPEAEFPVTELPGFTAAAVAGHAGTFRSYKINDKRVLVFLGRTHYYEGRGVAAVVHGVRTAVAAGCKTIVLTNGCGGLREGMRPGQPVLISDHINMTATSPIVGANFVDLTDLYSPRLRALCKEVDPTLEEGVYVQLPGPHYETPAEIKMVRTLGGDLVGMSTTLEAIAAREAGAEVLGISLVTNLAAGMTGEPLNHEEVLQAGRDSAARMGSLLAQVLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE4</accession>
    <name>A0A2G1XEE4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1330 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26485</name>
        <name evidence="3" type="ORF">CYQ11_19150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49575">
        <property type="protein sequence ID" value="PHQ49575"/>
        <property type="gene ID" value="BLA24_26485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14706">
        <property type="protein sequence ID" value="PPT14706"/>
        <property type="gene ID" value="CYQ11_19150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="114" mass="12298" checksum="4E36692F96919142" modified="2018-01-31" version="1">MTAYALAHLAQGAPNADVLEYMERIQTTLDPFGGRFLVHGATVEVREGTWPGALVVIGFPGIAEARAWYDSPAYQDILPLRTRHLAGDLLLVDGVAPGYDPKSLADKLRPQIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL8</accession>
    <name>A0A2G1XEL8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ORF">BLA24_27005</name>
        <name evidence="11" type="ORF">CYQ11_18625</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49662">
        <property type="protein sequence ID" value="PHQ49662"/>
        <property type="gene ID" value="BLA24_27005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14614">
        <property type="protein sequence ID" value="PPT14614"/>
        <property type="gene ID" value="CYQ11_18625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="337" mass="37065" checksum="B9C14770E7432DC4" modified="2018-01-31" version="1">MALDRPRALSGIQPTAGSFHLGNYLGAVRQYVALQETHDAFYMVVDLHAITVPQDPKELRANTRIAAAQLLAAGLDPDRCTLFIQSHVPEHAQLAWVMNCLTGFGEASRMTQFKDKSAKQGADRTTVGLFTYPVLQVADILLYQADTVPVGEDQRQHVELTRDLAERFNGRFGDTFRVPAAHIVRETAKIYDLQDPTAKMSKSAATAKGLINLLDEPKVSAKKIKSAVTDTDTVIRFDAEKKPGVSNLLTIYSTLTGTTIAELEQKYEGKGYGALKTDLAEVMVEWVTPFRARTQEYLDDPETLDAVLAKGAEKARTVAAETLARAYDKLGFLPAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEW2</accession>
    <name>A0A2G1XEW2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4245 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26130</name>
        <name evidence="3" type="ORF">CYQ11_19510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49745">
        <property type="protein sequence ID" value="PHQ49745"/>
        <property type="gene ID" value="BLA24_26130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16675">
        <property type="protein sequence ID" value="PPT16675"/>
        <property type="gene ID" value="CYQ11_19510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025339">
        <property type="entry name" value="DUF4245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14030">
        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="183" mass="19902" checksum="0DE25127D327E487" modified="2018-01-31" version="1">MAGRNGKTQTIRNMVLSMAVTVPVAGISYLFIPHDTGNDPVRTVNYRVELDTARRAAPYAVAAPEGLGEGWRATSVSYAPSGKQGSAWHLGFLDPQREYVAIEQSDASPRGFIDDVSQRAEKTGETRKVGDVTWDRYEGPRYDALVREEHGVTTVVTGTASEERLMEMAAALKAEKTKIANSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEW4</accession>
    <name>A0A2G1XEW4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19155</name>
        <name evidence="2" type="ORF">BLA24_22805</name>
        <name evidence="1" type="ORF">BLA24_29990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000163">
        <property type="protein sequence ID" value="PHQ48410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000153">
        <property type="protein sequence ID" value="PHQ49770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000150">
        <property type="protein sequence ID" value="PHQ50437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48410">
        <property type="protein sequence ID" value="PHQ48410"/>
        <property type="gene ID" value="BLA24_29990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49770">
        <property type="protein sequence ID" value="PHQ49770"/>
        <property type="gene ID" value="BLA24_22805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50437">
        <property type="protein sequence ID" value="PHQ50437"/>
        <property type="gene ID" value="BLA24_19155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="67" mass="7191" checksum="9AAEE5264C60E434" modified="2018-01-31" version="1">MLWAVSLSTMELIPHSLTAALSLTGIRSLAKVSNPVGPIAYPVLYLRQETHDAAPKCISGRTSYHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEZ4</accession>
    <name>A0A2G1XEZ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_19335</name>
        <name evidence="8" type="ORF">CYQ11_11465</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49806">
        <property type="protein sequence ID" value="PHQ49806"/>
        <property type="gene ID" value="BLA24_19335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13418">
        <property type="protein sequence ID" value="PPT13418"/>
        <property type="gene ID" value="CYQ11_11465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="448" mass="46864" checksum="E2501AF6B4CC93B9" modified="2018-01-31" version="1">MARKIGSRYTAHQVLGRGSAGTVWLGEGPEGPVAIKLLREDLASDQELVGRFVQERAALLGLDHPHVVGVRDLVVDGADLALVMDLIRGTDLRTRLDRERRLAPEAAVAIVADVADGLAAAHAAGVIHRDVKPENVLLDMQGPLGPGGAHPALLTDFGIARLVDAPRPAAPARDRERAPGQRRVIGTPDYLAPEIIEGLPPRASVDVYALATVLYELLAGFTPFGGGHPGAVLRRHVTETVAPLPGIPDELWQLVVQCLAKAPASRLRAPELAARLRELLPGLAGIPPLDIDEPEDEPAAATAGAGEREGAYEPVGASEPRRRGVVPLVPGGVSDSSRDTHTSMRVPGPEELAGGAHGTARAPRAPGQRRTGSARHRSSAEATRRRRIRIGTGLAVGLIAAAGAVGWFATSKQHDPGDAKPGVHRTTPPAGRTHAPNLSPDSSVAPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF36</accession>
    <name>A0A2G1XF36_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19390</name>
        <name evidence="4" type="ORF">CYQ11_11410</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49815">
        <property type="protein sequence ID" value="PHQ49815"/>
        <property type="gene ID" value="BLA24_19390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13409">
        <property type="protein sequence ID" value="PPT13409"/>
        <property type="gene ID" value="CYQ11_11410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="34708" checksum="1D551515A49A739D" modified="2018-01-31" version="1">MPNDIEPRLLRAFVAVADELHFTRAAARLYVAQQALSRDIRRLERGLGAELFVRTTRSVSLTGEGARLLPYVRHVLAAHDELAAACAGAERPLLVDVGARVSTGASVVAEVRRVAPDLELVCRYHSGLTGAAADLLSGRLDVSFGRVAGLAPELRAQLAWMPVRLEPMAVLLRDDHPLASRTAVPLNALRGETLYAAAGNAATAEWTDLAELLFEGRGITVAEPFPEIEGKDEFVRVVRKRGWSVLASVEFIDVPGMVLRPLTDPVPLSPVAMVWRRGLRHAGLDALRGAARKLAAAGGWLEPPEGGAWLPPGDTAAMGLAALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFA0</accession>
    <name>A0A2G1XFA0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF445 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19790</name>
        <name evidence="4" type="ORF">CYQ11_11000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49881">
        <property type="protein sequence ID" value="PHQ49881"/>
        <property type="gene ID" value="BLA24_19790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13343">
        <property type="protein sequence ID" value="PPT13343"/>
        <property type="gene ID" value="CYQ11_11000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="471" mass="50236" checksum="F5D5F72061CFA609" modified="2018-01-31" version="1">MKRSQGSRQGAQDLRGRRSGGSGPGGRPAGGREAGAASAAGVMPTAPGGFTYSAADEEKRRGVRRMKALATGLLLAVALVYALATWAQTSTAAGAGAWAGYVAAAAEAGMVGALADWFAVTALFRRPLGLPIPHTAIIPTKKDQLGQNLGEFVGENFLSGEVIRLRLRAVGIGSRLGAWLAEPAHADRVTAELATALRGALTVLRDADVQAVVDEAITRRAEAVEIAPGAGALLEKVVADGGHRRVVDLVCVRAHDWLVEHSDSVMQAVTGGAPGWTPRFVDRKVGERVYKELLRFVTEMRDMPDHPARGAVDRFLADFAHDLQTDDDTRTRVERLKSDVLGRGEVQDVIASAWSSVRAMVVAAAEDERSELRQRTRASILSLGARMTADDRLRGKVDGWLEDAAVYVVTTYRDEVTSLITDTVAGWDAEHTSRKIEAHIGRDLQFIRINGTVVGALAGLAIYTVSRLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFE4</accession>
    <name>A0A2G1XFE4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolC</name>
        <name evidence="2" type="ORF">BLA24_20260</name>
        <name evidence="3" type="ORF">CYQ11_10525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49953">
        <property type="protein sequence ID" value="PHQ49953"/>
        <property type="gene ID" value="BLA24_20260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13269">
        <property type="protein sequence ID" value="PPT13269"/>
        <property type="gene ID" value="CYQ11_10525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="331" mass="34421" checksum="F43D742B5088DD0B" modified="2018-01-31" version="1">MTGPYDLIAMGRLGVDLYPLQTGVSLAQVETFGKFLGGSAANVAVAAARLGRRTALISRTGDDPFGRYLHDALRDFGVDDRWVTPVAAYPTPVTFCEIHPPDDFPLYFYRRPKAPDLEIHPHELDLDAVRAARILWTTGTGLSEEPSRTATLEALASRAGSGTTVVDLDWRPVFWGGEGGASGAGGRSGPAAVAAARPHYAAALAHATVAVGNADECEVATGEREPHAAARALLAAGVELAVVKQGPEGVLAVHRDGTTVSVPPVEVDVVNGLGAGDAFGGALCHGLLAGWDLERTVRYAGAAGALVASRLACSSAMPTRDEVERLLEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFH2</accession>
    <name>A0A2G1XFH2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20420</name>
        <name evidence="2" type="ORF">CYQ11_10365</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49982">
        <property type="protein sequence ID" value="PHQ49982"/>
        <property type="gene ID" value="BLA24_20420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13241">
        <property type="protein sequence ID" value="PPT13241"/>
        <property type="gene ID" value="CYQ11_10365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="128" mass="14051" checksum="E69CDDC6274509B2" modified="2018-01-31" version="1">MPAAFAECYDPTGARHGIPTYPWRLAPDGLATRRQLRAHGLRPGGQPVVAQVMFHSRRRKTGVQVGYLYRVDRALPVRPMTPGRAAALAAAMLARRTCPTCRQDAGYCIPTSLGECVTCAYPEDQRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFW0</accession>
    <name>A0A2G1XFW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21300</name>
        <name evidence="2" type="ORF">CYQ11_09485</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50124">
        <property type="protein sequence ID" value="PHQ50124"/>
        <property type="gene ID" value="BLA24_21300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13095">
        <property type="protein sequence ID" value="PPT13095"/>
        <property type="gene ID" value="CYQ11_09485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="9683" checksum="D64AFF28DD29ADC0" modified="2018-01-31" version="1">MRIVITRTGGFAGIERRAELDTCGRSDATHLEALAHRALAPGREAPTRGVPDGFHYEINVDGRSVHLADPHLTEEQRELIRTVLKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFY0</accession>
    <name>A0A2G1XFY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21405</name>
        <name evidence="3" type="ORF">CYQ11_09380</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50143">
        <property type="protein sequence ID" value="PHQ50143"/>
        <property type="gene ID" value="BLA24_21405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13075">
        <property type="protein sequence ID" value="PPT13075"/>
        <property type="gene ID" value="CYQ11_09380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="334" mass="35679" checksum="49041AAB662A51C4" modified="2018-01-31" version="1">MQQRTLGTTGPQVSALGLGCMGMSALYGDADRTESIATIHAALDAGVTLLDTGDFYGMGHNEMLIGEALRSAPAAARERALTSVKFGALRGPDGDWSGYDGRPAAVKNFAAYSLQRLGVDHIDIYRIARVDPDVPIEETVGAIAELVEAGHVRHIGLSEVGADTIRRAAAVAPIADLQIEYALITRGIEERILPACRELGIGVTAYGVLSRGLISGHFSRDRQLPANDFRGMSPRFQGENLQRNLDLVDALRKVAEEREASVAQIAIAWVLSRGEDIVPLVGARRRDRLTEALGALDVALDADDLAAIEQAVPADAAAGERYPAEQMAHLDSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFY1</accession>
    <name>A0A2G1XFY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21435</name>
        <name evidence="3" type="ORF">CYQ11_09350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50146">
        <property type="protein sequence ID" value="PHQ50146"/>
        <property type="gene ID" value="BLA24_21435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13071">
        <property type="protein sequence ID" value="PPT13071"/>
        <property type="gene ID" value="CYQ11_09350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="674" mass="72799" checksum="E6C76231AE751F58" modified="2018-01-31" version="1">MPGPDVTVVIAAYNAMPYVTRSVTSVLEQTLGADRIELLAVDDGSTDGTGAELDRLAAKAPLMRVIHQPNSGGPAGPRNTALDLATGRYVFFLDADDHLGPEALERMVAAADDNGSDVVLGRIVGEGGRRAPRSMFGRNQPRTDVFSSRVYWTLNPMKLFRRTLVDRLGLRFATGLSIGEDQPFTATAYLEAAAISVVADYDCLYWVAREDGHNITSQPHGTRTRIDLLRLMTALVAERVEPGPDRDTLMHRHFAVELRDAVLQLCREPHRDVQDKYLKELGDLIEPYYHEGLAARLPAVVRLRCHLVRRGLLDELLTLVRWELDRGAASYGITTLAATAADGPEVLTENGRAYALYPYFRDSTLNIPVDCYDITGELRVRHLVESADLDGTGLRLTGHAYVHRIATREVTTELILRKRGTGAEHRLPVRHTATPGLGADEDGGRFDYGTAGFDVTVDPATAAGGAPLDAGMWDLFLAVGAQGVVKEARLGSRRADSVTVATTTVVTAAGTAAALFTTKPYGNLTLDLGETRHRVPPRLRVTGATWAADAPATLVVTGRCTLASWPAGALTVRAVCADGTTLTVPVETAADGSFAARVPCTTAGEWRIDGCLAAGDKKWTVPVPVKSPLRAARWQRLGLPWYAKPVAGGETLTLRVGRVELLKAVKGRLTRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG29</accession>
    <name>A0A2G1XG29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACP S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21620</name>
        <name evidence="4" type="ORF">CYQ11_09165</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50177">
        <property type="protein sequence ID" value="PHQ50177"/>
        <property type="gene ID" value="BLA24_21620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13040">
        <property type="protein sequence ID" value="PPT13040"/>
        <property type="gene ID" value="CYQ11_09165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="318" mass="32784" checksum="B7C7914DD6E4CD45" modified="2018-01-31" version="1">MLVLVAPGQGAQTPGFLTPWLDLPGVSDRLTEWSSAIGLDLVHYGTNAGDDEIRDTAVAQPLLVASALVSARQLFAGPDDFSRVVGAAAGHSVGELAAAALTGVLSERSVMELVRRRGLAMAEAAAVTETGMAALLGGEPDVVLPHLERLGLTPANVNGAGQIVAAGTKEQLEALAAEKPEGTRKVVALKVAGAFHTHHMAPAVSALESAVRELSPADPHTAYVSNKDGRVVSDGREVVARLVGQVANPVRWDQCMETFKELGVTAIIEVAPGGTLVGLAKRALPGVRTLALKSPDNLEAARELIAEYASDAAGSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGD9</accession>
    <name>A0A2G1XGD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Winged helix family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_22420</name>
        <name evidence="5" type="ORF">CYQ11_08365</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50308">
        <property type="protein sequence ID" value="PHQ50308"/>
        <property type="gene ID" value="BLA24_22420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12905">
        <property type="protein sequence ID" value="PPT12905"/>
        <property type="gene ID" value="CYQ11_08365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="209" mass="22282" checksum="25C47DD5757A1F93" modified="2018-01-31" version="1">MTNLRTVTASSPAAPTLPSPAHRHRLRAVAPDEVPPVAELLHPGATWMPAPQHTLPDLPGQPPMIGYLVLVPADQALSAAPGLPAPVPAPRAPGAQGPDVPGPAAPRTLTEGDALVRIDPEQRTAHIAGKPLDLTYLEFELLAHLVAHPHRVHTRDQLVTTVWGYGHVGDGRTVDVHVARLRRKMGAEHRSSIVTVRRVGYKYAPPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGE7</accession>
    <name>A0A2G1XGE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22480</name>
        <name evidence="2" type="ORF">CYQ11_08310</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50318">
        <property type="protein sequence ID" value="PHQ50318"/>
        <property type="gene ID" value="BLA24_22480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12895">
        <property type="protein sequence ID" value="PPT12895"/>
        <property type="gene ID" value="CYQ11_08310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="72" mass="8381" checksum="7B6D9C58D18D04B6" modified="2018-01-31" version="1">MTVMAYDYDYDAQRADDERQNHLACHVAEYVCHPRHDAEFAAALYSATIAEFEAKEWGDYPPEGHGYPREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGF8</accession>
    <name>A0A2G1XGF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22460</name>
        <name evidence="3" type="ORF">CYQ11_08330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50314">
        <property type="protein sequence ID" value="PHQ50314"/>
        <property type="gene ID" value="BLA24_22460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12899">
        <property type="protein sequence ID" value="PPT12899"/>
        <property type="gene ID" value="CYQ11_08330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="30065" checksum="EA21B906C4C71D5F" modified="2018-01-31" version="1">MQITNALRAAILTKTLTPGERLPSQNELTKRYQVSRATVQRALRDLQDEGLIVARQGSGVFVRSKTERPMALRPHIEQAFAADEVTIDFAGFSGETLYGAIREPIDRIRTGRLRPQSINLRVLVPDTRKPQALPASLDPSVTAEQVRERAHRIMLRSTQGIVDAVTELEILGLIEQARVSVRVHGFTPSFKLYILNQRDVFFGFYPVTPNTVPIGGEPVKILDVLGLDATLFPFSQGDDRNGNETQWVEQSQLWFDSVWDNLGEDFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH26</accession>
    <name>A0A2G1XH26_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase DnaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_17125</name>
        <name evidence="7" type="ORF">CYQ11_16150</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50540">
        <property type="protein sequence ID" value="PHQ50540"/>
        <property type="gene ID" value="BLA24_17125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14206">
        <property type="protein sequence ID" value="PPT14206"/>
        <property type="gene ID" value="CYQ11_16150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="203"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="501" mass="53749" checksum="E3EF5ADD36FE9241" modified="2018-01-31" version="1">MPSHQAAGPASPTDMTVQPPHDAEAERAVLGACMHGPDVIDEVRAMLDAGDFYRPHHETIWRALLALRGEDKPTDPIAVSDLLTRQGDINRVGGIVYVHQLYGAPPSASHAAYYADIVRRAAALRRLREHGIRTVQRTQEPGADPDEIRSAIETDIGAERERALASGCGRLSRYLVDGWRFVTETGADKEPLWGTREKTAWASGESLMIVGAPGVGKTTLAHQVILARIGLQESVLDMPVAPSKRVLYLAMDRPQQIARAMARRIGVKDEAILRERLAVWQGPLPATLDKEPDLLSDLAAAHQADTIVIDSLKDAVSTLVDDALAVAFQNARMRALRNGVEVMELHHQRKSPADASRDQRPALDRVYGSTWITSGAGSVLFISGEAGDPAVTLHHLKTPTGEIGPLQLIHDHAHGTTTVDPALDPVTILRAAPGGLSVRDLAIAQTGTTNPDRAAVEKARRTLDSLVKAGLATKTEGIAGGTGGGQQTRYHASARHIAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH31</accession>
    <name>A0A2G1XH31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17145</name>
        <name evidence="2" type="ORF">CYQ11_16130</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50543">
        <property type="protein sequence ID" value="PHQ50543"/>
        <property type="gene ID" value="BLA24_17145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14203">
        <property type="protein sequence ID" value="PPT14203"/>
        <property type="gene ID" value="CYQ11_16130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="69" mass="7251" checksum="85A306624DED061A" modified="2018-01-31" version="1">MPVFPGTAMPGPAPRLTLQQRLRASVKPLVDPPEDSPGAAFVAAHGDPATWSGETCDAYLDLVHAEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH87</accession>
    <name>A0A2G1XH87_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17190</name>
        <name evidence="3" type="ORF">CYQ11_16085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50551">
        <property type="protein sequence ID" value="PHQ50551"/>
        <property type="gene ID" value="BLA24_17190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14195">
        <property type="protein sequence ID" value="PPT14195"/>
        <property type="gene ID" value="CYQ11_16085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="15103" checksum="BB4881BB75865C60" modified="2018-01-31" version="1">MDPITAAALTALAGGLGGEAGRQAWQGLAALVRRPFGRAAAQGTQDDGTPQVSSGELEVAALEEEPADPMRAQALATALGVRAALDGEFRVLLDEWWQRAHANSSGGNVHNNISGGTQNGPVLQGRDFSSLTFNMTRTMASSDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH93</accession>
    <name>A0A2G1XH93_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2867 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16915</name>
        <name evidence="2" type="ORF">CYQ11_16365</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50509">
        <property type="protein sequence ID" value="PHQ50509"/>
        <property type="gene ID" value="BLA24_16915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14235">
        <property type="protein sequence ID" value="PPT14235"/>
        <property type="gene ID" value="CYQ11_16365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="21961" checksum="81E084173754793D" modified="2018-01-31" version="1">MRLPNSAHTSRPWRIHEIAGDFRIDDVWALPTPGGPDDLAWLVRQFANGDPEAASPVSSPVASFLFAVRWKLGKLLGWDKDDSGVGARVPTLHDRLPADLRDGPRGPDTASTPFTSVYQTHDEWVAEMGNRTVHALMHIGWVPDGAGGYRGQMAVLVKPNGLLGVAYMAAIKPFRYLLVYPALLRTIGREWQAGAAERSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHE1</accession>
    <name>A0A2G1XHE1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCA tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_17880</name>
        <name evidence="5" type="ORF">CYQ11_15395</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50664">
        <property type="protein sequence ID" value="PHQ50664"/>
        <property type="gene ID" value="BLA24_17880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14081">
        <property type="protein sequence ID" value="PPT14081"/>
        <property type="gene ID" value="CYQ11_15395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="275"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="486" mass="54985" checksum="884A8E0B68649456" modified="2018-01-31" version="1">MPNANNDSHTPSSTNELNQVQRRAVSELLRVSPVADDLARRFQEAGFTLALVGGSVRDALLGRLGNDLDFTTDARPEDVLKIVRPWADAVWEVGIAFGTVGCRKSDFDIEVTTYRSEAYDRTSRKPEVSYGDSIEEDLVRRDFTVNAMAVVLPEKQFVDPHHGLEDLAARVLRTPGTPEESFSDDPLRMMRAARFAAQLDFEVAPEVVTAMTEMSDRLEIVSAERVRDELNKLIVSSHPRKGLRLLVDTGLARLVLPELPALRLERDEHHRHKDVYEHTLTVLEQAMDLEKDGPDLVLRLAALLHDIGKPRTRRFEKDGRVSFHHHEVVGAKMTKARMTKLKYSNDLVKDVSKLVELHLRFHGYGTGEWTDSAVRRYVRDAGPLLDRLHKLTRSDCTTRNKRKANALSRAYDGLEERIARLQEQEELDSIRPDLDGNEIMEILGIRPGPQVGQAYKHMLELRLEHGPLGRDAAVAALKEWWAAQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHP1</accession>
    <name>A0A2G1XHP1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6458 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18365</name>
        <name evidence="4" type="ORF">CYQ11_14915</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50745">
        <property type="protein sequence ID" value="PHQ50745"/>
        <property type="gene ID" value="BLA24_18365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13998">
        <property type="protein sequence ID" value="PPT13998"/>
        <property type="gene ID" value="CYQ11_14915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045597">
        <property type="entry name" value="DUF6458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20059">
        <property type="entry name" value="DUF6458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6458" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="8069" checksum="F35CE02FA823653A" modified="2018-01-31" version="1">MGITWCIGLIAAGAILTFAVDWQIDGVNVPLVGLILMAAGFLGLCAYVSIFRRRRTQPPPPAATVVEEDHRYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHX7</accession>
    <name>A0A2G1XHX7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="3" type="ORF">BLA24_19025</name>
        <name evidence="4" type="ORF">CYQ11_14255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50848">
        <property type="protein sequence ID" value="PHQ50848"/>
        <property type="gene ID" value="BLA24_19025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13894">
        <property type="protein sequence ID" value="PPT13894"/>
        <property type="gene ID" value="CYQ11_14255"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="243"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="29202" checksum="660577D4EEF8516D" modified="2018-01-31" version="1">MPENHSSTAPATSPVPAPARARREPMFPDGPAPDPAGSHHERRIRSFQPRRSRVTPGQGDALRRLWPQWGLDIDGLSRLDLGELFGDPDLPVVLEIGFGMGEATAQMAAADPGTGILACDVHTPGQGNLLGLAERNGLANVRVANGDAIILLREMLAPDSLAGVRVYFPDPWPKKRHHKRRLIQPEFLALAATRLAPGGLLHCATDWEPYAEQMLEVLSASPDFENTQPDGGFAPRPEFRPLTRFEGQGLDKGHVVHDLLFRRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIA6</accession>
    <name>A0A2G1XIA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dacB</name>
        <name evidence="4" type="ORF">BLA24_16600</name>
        <name evidence="5" type="ORF">CYQ11_16685</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50859">
        <property type="protein sequence ID" value="PHQ50859"/>
        <property type="gene ID" value="BLA24_16600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16613">
        <property type="protein sequence ID" value="PPT16613"/>
        <property type="gene ID" value="CYQ11_16685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304896" evidence="3">
        <location>
            <begin position="27"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="471" mass="46852" checksum="12997CA46CBE6751" modified="2018-01-31" version="1">MAQRRTVRFVAVSTVAGLVVATGAVAAAGPWDGGQRKAERDRAAAGTRAGGGDHGGAGRAGGAGAGRRAAPPVLGALGGGAARAAGLAGVLDPLLKDAALGPEPSAAVYDAGTGERLYGAGQDTGYTPASTIKLATAAAALAALGPEHRIETTVVAGSDGVVLVGGGDPTLTARPVKGEGPRFASLGDLADATVKALKARGTTRTRLAYDASRYSGPPLHPIGPNENLAPVSALMADEGRLDDSDRGVADRTAEPAADAARKFAAMLRERGVEVEGEPAEGRADAKAERLATVSSAPLADLVERALTNSDNDVAEALARQTALASGRPASFEGAAQAVTERLTGLGLPMAGVHIADGSGLDRSGRASADFLARLLLRSASADSARLRPVLTGLPVAGFTGTLRERYGREVAGRASVRAKTGTLTGVNTLAGTAVTAGGRLLVFAFMASGTADAGGAQQALDRLASALAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XII7</accession>
    <name>A0A2G1XII7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fic family toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_14940</name>
        <name evidence="2" type="ORF">CYQ11_13130</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51072">
        <property type="protein sequence ID" value="PHQ51072"/>
        <property type="gene ID" value="BLA24_14940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13705">
        <property type="protein sequence ID" value="PPT13705"/>
        <property type="gene ID" value="CYQ11_13130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="13063" checksum="EE55E68B894318FB" modified="2018-01-31" version="1">MTLHVDLSWLLEAARLSGNGDPAPEDYGVPIAAVERHKAVLAGQDVYHGVYARAGALVHTLGRLPWLERSNLRVAVGVAQGYLGASGIQVKLTQERVTALAIELKRPASTAASVAAVLRGWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIS5</accession>
    <name>A0A2G1XIS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_15235</name>
        <name evidence="6" type="ORF">CYQ11_12835</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51125">
        <property type="protein sequence ID" value="PHQ51125"/>
        <property type="gene ID" value="BLA24_15235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13653">
        <property type="protein sequence ID" value="PPT13653"/>
        <property type="gene ID" value="CYQ11_12835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="977" mass="104538" checksum="7AD71FA3CC588655" modified="2018-01-31" version="1">MAGDTGHGQQLRFTVLGPVRAWRGDEPLHTGSPQQRALLAALLLRGGRTATAPELVDALWGEEPPHAALAALRTYASRLRKAFGPDADALVSESGGYAIRVGYGGLDIDTAERLAAEADKARGAGDRARARELMNEALDLWDGEPLAGLSGPYADTQRARLEEWRLSILETRLDLDLEVGCHAEAVSELTALTAAHPLRERLRELLMLALYRSGRQAEALAVYADTRRLLADELGVDPCSELSELQQRILNADIALNVHPAAADRPAAGPTFIRPAQLPATVSDFTGRTAFVSELSEQLATAEGRVMAVSAVAGIGGVGKTTLAVHVAHAARHQFPDGQLYVDLQGTGPVVAEPEAVLGSFLRALGVPDSAIPDGVEERSALFRSTLDGRRVLALLDNARDAAQVRPLLPGNEGCAALVTSRARMVGLAGAHLVDLDVMSPEEALVLFTRIVGPERVDSERDAAMDVVAACGFLPLAIRIAASRLAARRTWTVSVLARKLGDERRRLDELRAGDLAVKATFELGYGQLEPAQARAFRLLGLADGPDISLAAAAAVLDLDLDATEELLESLVDTSLLESAAPGRYRYHDLLRLYARSCAERDELPPSEREAALSRLLDFYLATAAGVYVLERPGDQLLTHLTPTTHPGLTFTDRGAAGDWLFAEAGCLLACVRQHSGASGDTTRRAVDLLLAAKDLAESGADSRQYEQAATALLASAQATGDTRAEGRARTVLAHVHSIAGRFAQADAQARQAVQLGRASEDPIPCCYAANNRGIIAIYEHRHEDAEAYIGQALAAFRADGNKPGEASALCNLSRAHLGAGRVQSAVRLTEQAIALYRETNVSWRLANALYAYAVALTSAGRHEEAMARLQEALPVFRDNRQRLWEGMTLFRMAELYLAVREPAKAAAHAEHALAQLRDTGGGWRRANILTVLGRSLDAFGQSGRAHACWTEALGIFEQLGSSEAAEVRELLTPVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIS9</accession>
    <name>A0A2G1XIS9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TIGR03619 family F420-dependent LLM class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15305</name>
        <name evidence="3" type="ORF">CYQ11_12765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51137">
        <property type="protein sequence ID" value="PHQ51137"/>
        <property type="gene ID" value="BLA24_15305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13641">
        <property type="protein sequence ID" value="PPT13641"/>
        <property type="gene ID" value="CYQ11_12765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="30944" checksum="E8A78F7D9D198B7D" modified="2018-01-31" version="1">MRIATTIFLTDETISPVRLARELEQRGFAGLYLPQHTHIPVSRATPAPMGEPLPPEYGRAVDPFVALAQAAAVTHRIEVGTGVTLVAQHDPVVLAKQVATLDFLSGGRFTFGIGYGWNVEEAADHGVEWRSRRELVRDRMAAMRALWAPEPTAYEGEYVSVQASWAHPKPQRAPRERKGVEPLIGPRTLIGGTAGPKLFAHIAEYADGWMPVGSSGLRETLPELRRAWAEAGRPGEPEVVPYAVHPSTGKLAHLADLGIEEVVVGMPSAPEADVLRALDAHAEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIX8</accession>
    <name>A0A2G1XIX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15720</name>
        <name evidence="4" type="ORF">CYQ11_12355</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51202">
        <property type="protein sequence ID" value="PHQ51202"/>
        <property type="gene ID" value="BLA24_15720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13574">
        <property type="protein sequence ID" value="PPT13574"/>
        <property type="gene ID" value="CYQ11_12355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="199" mass="21996" checksum="C43E10BA40E55BFA" modified="2018-01-31" version="1">MPTEPPKPAVRRTRLTPEREAELYEAVLALLREVGYDALTMDAVAARTHASKATLYRQWRGKPELVAGALRHNKPMSLADIDTGTVRGDLQAMVCDADKDRMEKDAALMRGLQRAIHDHPDLKRALRELLVEPEIAALEAMLRRAVDRGEVAPDNPALDYVAHMVLGAFMARPLVEDRPADGAYLTRYIDAVILPALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIZ3</accession>
    <name>A0A2G1XIZ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15480</name>
        <name evidence="4" type="ORF">CYQ11_12595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51161">
        <property type="protein sequence ID" value="PHQ51161"/>
        <property type="gene ID" value="BLA24_15480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13616">
        <property type="protein sequence ID" value="PPT13616"/>
        <property type="gene ID" value="CYQ11_12595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="227" mass="24932" checksum="027325808E415004" modified="2018-01-31" version="1">MFVVATASQPRLRADALRNRERIVTAAREVLVEHGVESSLDEIARRAGVGNATLYRHFADRRELIHHVTLFVMGRIADQAETARSEESDAFQALRRFVHAAADERIGALCSLLADSGVDRDHPDHVVARERTEVAIEALLADARAAGQLRDDIAIGDLMVAITQLTRPLPDSGCIDFDQFVHRHLQLFLDGLAAPARSRLPGTPVTLDDLRQKAAQAASRTTDLSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ96</accession>
    <name>A0A2G1XJ96_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_15755</name>
        <name evidence="7" type="ORF">CYQ11_12320</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51209">
        <property type="protein sequence ID" value="PHQ51209"/>
        <property type="gene ID" value="BLA24_15755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13567">
        <property type="protein sequence ID" value="PPT13567"/>
        <property type="gene ID" value="CYQ11_12320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="27194" checksum="8E52D3E2FFE303BA" modified="2018-01-31" version="1">MTTPASLEVSGLAFAYPDGHQALFGVDLTVGRGERVALLGPNGAGKTTLVLHLNGILSGGAGTVRVAGLPVGKRNLAEIRRRVGIVFQDPDDQLFMPTVREDVAFGPAAAGLRGAELEACVRTALERVGMAAFADRPPHHLSFGQRRRVAVATVLAMEPEILVLDEPSSNLDPASRRELADILRSLDVTVLMVTHDLPYALELCERSVVLSDGVIAADGPTGDLLRDEDLMRAHRLELPFGFDPGAVAARPATAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJF9</accession>
    <name>A0A2G1XJF9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15795</name>
        <name evidence="3" type="ORF">CYQ11_12280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51365">
        <property type="protein sequence ID" value="PHQ51365"/>
        <property type="gene ID" value="BLA24_15795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16512">
        <property type="protein sequence ID" value="PPT16512"/>
        <property type="gene ID" value="CYQ11_12280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="131" mass="14889" checksum="93662DCCD326E1B0" modified="2018-01-31" version="1">MHTATAQSPKPFETVYESYAFACMRCAHAWEQSYEIRHHVDAEGQPFVTYYADDKRVPSPLTRPTCENCGEHVVRIMRPGQVSVVADALHLPKPSVFPQATTGPLQNGGSHEPHPRHHWHLSDLLKPFHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJI6</accession>
    <name>A0A2G1XJI6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HPr-rel-A system PqqD family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">PqqD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13840</name>
        <name evidence="2" type="ORF">CYQ11_01535</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51412">
        <property type="protein sequence ID" value="PHQ51412"/>
        <property type="gene ID" value="BLA24_13840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11753">
        <property type="protein sequence ID" value="PPT11753"/>
        <property type="gene ID" value="CYQ11_01535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="84" mass="9010" checksum="CBAE58927660CCDA" modified="2018-01-31" version="1">MALRLGTDVCTALTDYGTVLLDQRSGEYWELNPTGTIVVQTLLEGGEQGDAVDALVTEFDVERSQAVRDVTALIAQLRATGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJN3</accession>
    <name>A0A2G1XJN3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_15120</name>
        <name evidence="6" type="ORF">CYQ11_12950</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51349">
        <property type="protein sequence ID" value="PHQ51349"/>
        <property type="gene ID" value="BLA24_15120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16529">
        <property type="protein sequence ID" value="PPT16529"/>
        <property type="gene ID" value="CYQ11_12950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="193"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="340" mass="36166" checksum="9212DC1559A7C332" modified="2018-01-31" version="1">MDFRPSDDQRALRAGMRDVLTSCFPPERLREVLDGGGVEGAATRELWRELGDAGLFSLRLPEEEGGVGLGLTEAVFVFEEAGRALVPGPLVETYLAAGLVPGAAEGTAVVTALDRPGVVGHLAAADAVLLFDGPVVRLLDAAGGAGPGKLEARPVRSVDPLTPLHHVLRLPRIPSLAPTVTADALRLTREAVLLTAAQQLGSSARTLEMAVSHAKSRTQFGRPIGAFQAVQHICAQMLVRTELARSSVYAASLTITASEVSGAKILADEAAVRNARDCLQLHGGLGFSWDAEVHPHVKRAWWRVQQWQPVADAEEELAAALLRRAENCSSEIANFPERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJP0</accession>
    <name>A0A2G1XJP0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13705</name>
        <name evidence="3" type="ORF">CYQ11_01400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51391">
        <property type="protein sequence ID" value="PHQ51391"/>
        <property type="gene ID" value="BLA24_13705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11731">
        <property type="protein sequence ID" value="PPT11731"/>
        <property type="gene ID" value="CYQ11_01400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="54475" checksum="C084E156E7C462AE" modified="2018-01-31" version="1">MPKGDAAPGLTCLVTGATGYIGGRLVPELLAAGYRVRALARSPAKLRDHPWAGDVEVVRGDVTDAASVGAALRGIDVAYYLVHALGTGETFEETDRRSARIFAEQASAAGVRRVVYLGGLTPAGVPEETLSPHLRSRAEVGRILLESRVPATVLRAAVIIGSGSASFEMLRYLTERLPAMVTPRWVHTRTQPIAVRDVLRYLVGSARMPQDLNRAFDVGGPDVLTYGDMMRRYAVAAGLPRRLIVPVPVLTPRLSSQWIGLVTPVPPSIARPLLESLRHEVVCHEHDVAHHVPDPPGTPLPFDTAVSLALERVQEAQVATRWSSASVPGAPSDPLPTDPDWAGGSLYTDHREVCVPASREALWRVVEGIGGENGWYSFPLAWAVRGWLDRLTGGVGLRRGRRDPARLRVGDSLDFWRVEEIEPGHLLRLRAEMRLPGLAWLEMYAESDADGRTRYRQRALFHPRGLAGHAYWWGVSPFHALVFGGMARNVARAAARDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK08</accession>
    <name>A0A2G1XK08_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12820</name>
        <name evidence="3" type="ORF">CYQ11_17175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51578">
        <property type="protein sequence ID" value="PHQ51578"/>
        <property type="gene ID" value="BLA24_12820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14370">
        <property type="protein sequence ID" value="PPT14370"/>
        <property type="gene ID" value="CYQ11_17175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="26604" checksum="41C41FF5B4DAF97A" modified="2018-01-31" version="1">MTSPILVTGGTGTLGGHVVPLLRAAGRDVRVLSRHAREPEEGVAYVTGDLLKDEGVEAAVAGSEIVLHLAGGPKGDDVATRNLVRAASRAGVRHLVYISVIGADTVPLGYFAAKLGAERAVAESGLPWTTLRAAQFHDLVLKVVRTMAKLPVIPAPGGVRMQPVDAREVAARLVELTLGDPAGLVPDLAGPKVYPMAELAHGYLRTQGKRRPTLPLRMPGKAGRAYRAGENLSLEGAALGVRTWEDFLAERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK16</accession>
    <name>A0A2G1XK16_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_13130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000144">
        <property type="protein sequence ID" value="PHQ51550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51550">
        <property type="protein sequence ID" value="PHQ51550"/>
        <property type="gene ID" value="BLA24_13130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="4">
        <location>
            <begin position="452"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="592" mass="62090" checksum="DEA35C94C2FB54A6" modified="2018-01-31" version="1" fragment="single">GDKCAGVYRTDSGLCTHGPDAPPKGVDIAKDTAPAVKAKAAASDPERPEAAEPAPGKRPQDAPAALDAATGKATDPGAAAGGTPATPTTPSTPADGPAGQTVQCDGDGSTGNRVQVVYAHGPGRDRYAEYAASFKKWAADADLIYSTSAKETGGIRHIRYVTSADCTPSVLDIELPDSALSEFSATNRALAAKGLDRRDRKYMVFADAQVYCGIGTFNGDERPGQDNLSNFGPSYGRTDNGCWGGHTAAHELGHNLGAVNNSAPNTSRGAHCTDEWDVMCYSDSPYYPQMRTVCTDREAENVLDCNHDDYFHTNPRPGSYLATHWNIADNQFLMKANGNGTQPNPNPSPTPTTRPTADPGPSGTTGPEVTVGQVSADSAVVSWKPVSNAAWYQIVLNGKHMAWVQPSVVRIYNLQPGTQYTVAVAVRDRAGHDTKPGKASSFRTTGSGGGTTAPNTRYLLNNGGTGNAAEIWGGRTADGTVLVGSRTNGYAGQQWYFDDAGSGYQRIRSAVSGKCLQLGGPAGAGTWVAQQPCGNADSQKWRLSPKGSGVTVAAKSGNYVLGVSNRPYYGSWLLELQSPDGRAAQVWAVQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK88</accession>
    <name>A0A2G1XK88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2993 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12900</name>
        <name evidence="2" type="ORF">CYQ11_17260</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51591">
        <property type="protein sequence ID" value="PHQ51591"/>
        <property type="gene ID" value="BLA24_12900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14384">
        <property type="protein sequence ID" value="PPT14384"/>
        <property type="gene ID" value="CYQ11_17260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="23878" checksum="24C2E28FF4553B42" modified="2018-01-31" version="1">MRAIRTILITAVILGGLFVAADRGAVWFAEKQAAEKIRDSQGLSGTPEVSIKGFPFLTQVASSELDEVEVKLDGVTAGAGDRSVKVSGFDATLHGVRIDSSFSSAVAGRATGTAHLSYEDLTKAAGDPDVSVAYSGTSGSQVKVTGKVTVAGQPVERSVVSTVTVVNGGTIRVHADEVPSQGVPGAERKIREKTDFDRQIAGLPKGLKLDKVTATPSGVDVTLTGSDVNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKD3</accession>
    <name>A0A2G1XKD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11525</name>
        <name evidence="3" type="ORF">CYQ11_02760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51714">
        <property type="protein sequence ID" value="PHQ51714"/>
        <property type="gene ID" value="BLA24_11525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11963">
        <property type="protein sequence ID" value="PPT11963"/>
        <property type="gene ID" value="CYQ11_02760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="24033" checksum="E76FB4A8F5A003F3" modified="2018-01-31" version="1">MCPRRQGVDMNDVQDATTRYLMYGVLPGWFVPGLADWVMHRRTRIEDTSGTKESAIHSLMMAEVGVPIVLTLLCEVNPLLMTVQLGATAAHEATALWDVRTAVRSDREVKPVEQHIHSFLETLPFAALASLMCLHPGQVRSLLRGGRGDAKAWRLVPRRDPLPRSYLAGIGLGVAACVALPYAEEFVRCVRGARGRRKARKRSGRSTDEQFTERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKG0</accession>
    <name>A0A2G1XKG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11590</name>
        <name evidence="2" type="ORF">CYQ11_02825</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51725">
        <property type="protein sequence ID" value="PHQ51725"/>
        <property type="gene ID" value="BLA24_11590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11973">
        <property type="protein sequence ID" value="PPT11973"/>
        <property type="gene ID" value="CYQ11_02825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14339" checksum="3E2ECFDDD997BCE4" modified="2018-01-31" version="1">MSHPMPPHASKRRKWPWVLLVLALLIVGGCAALFLIVSKEYDKTVTVRYEVTGDAKDASVSYSTWDNGAIKATKAGPLPSLPWRKVITTKGFAKGGVLAASTGAGGGTVTCKVTVDDGKPVVDSARGAYATATCQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKR3</accession>
    <name>A0A2G1XKR3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11315</name>
        <name evidence="3" type="ORF">CYQ11_02550</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51844">
        <property type="protein sequence ID" value="PHQ51844"/>
        <property type="gene ID" value="BLA24_11315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16307">
        <property type="protein sequence ID" value="PPT16307"/>
        <property type="gene ID" value="CYQ11_02550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="51" mass="5809" checksum="C0B5E5A20C931CCC" modified="2018-01-31" version="1">MLPLLLVLLLVVILFGAGFAVKILWWIALVVLVLWLIGFVARSGGGRWYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKT0</accession>
    <name>A0A2G1XKT0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">BLA24_12160</name>
        <name evidence="6" type="ORF">CYQ11_03400</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51826">
        <property type="protein sequence ID" value="PHQ51826"/>
        <property type="gene ID" value="BLA24_12160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12073">
        <property type="protein sequence ID" value="PPT12073"/>
        <property type="gene ID" value="CYQ11_03400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="26503" checksum="A4996C9C052D1EDD" modified="2018-01-31" version="1">MITLMSSTELETMREAGRVVAKALDTVRQKAAVGVSLLELDEIAAAVIDDAGATSSFRGYHPGHAPTPYPGVICSSVNDAVVHGIPNGYRLQDGDLVSIDCGASVDGLHGDSAVSFVVGEARPDDLELVDTTERALRAGIDALQPGARMGDVSHAIGVIGRAAGYGLLENHGGHGVGRAMHQDPFVPNEGRAGRGMRLRPGLVLALEPMFLAGGRDGYRVAGDGWTLRTLDGSRAAHAEHTVAVTEDGPLMLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKW8</accession>
    <name>A0A2G1XKW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3995 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000130">
        <property type="protein sequence ID" value="PHQ51904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51904">
        <property type="protein sequence ID" value="PHQ51904"/>
        <property type="gene ID" value="BLA24_11020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="103" mass="11050" checksum="302F3C8DB4DE0FBD" modified="2018-01-31" version="1" fragment="single">MSITRSPDDIARRVPRRAVRLHLSAWPGYAAAGWGFLFAVPSFVWATGSTFGARTTVSPSLVQLARDGVPWFVAVLVVTGFLKLVGALLGIGLTRARGARISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL47</accession>
    <name>A0A2G1XL47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_10430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000119">
        <property type="protein sequence ID" value="PHQ51984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51984">
        <property type="protein sequence ID" value="PHQ51984"/>
        <property type="gene ID" value="BLA24_10430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="198" mass="21914" checksum="263D7EFB8C70840F" modified="2018-01-31" version="1">MGADITALIVDWADLENIPVLEREGALIEAADPDVDDGGTEEGWAWLPPAPEGFPAWCARYEFASTRGSFKPHFWAGERWETVREHVAADLRSALDTFLGGLFWNLPGSEDDLQEEDAEHWYGAMWVYCSPPDVLGLAQAWAEAGPRLEALRGPFDLHAAEPGTRVGRFEGFAMLLRGWAEVVDEAHRRGWGLVGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL55</accession>
    <name>A0A2G1XL55_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51957">
        <property type="protein sequence ID" value="PHQ51957"/>
        <property type="gene ID" value="BLA24_10890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="66" mass="7007" checksum="215947E1CB9C6E6E" modified="2018-01-31" version="1">MSETDASPHPFRALSQGVRDAGHPDPARVARTLVTLRDGAMVGGCLDVPRPVRATLREAAQNLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL58</accession>
    <name>A0A2G1XL58_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000115">
        <property type="protein sequence ID" value="PHQ51994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51994">
        <property type="protein sequence ID" value="PHQ51994"/>
        <property type="gene ID" value="BLA24_10320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="126" mass="13560" checksum="B4FC34318F4411E9" modified="2018-01-31" version="1" fragment="single">MVEQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIITECGPLPAQAVRWLAAGVAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLA4</accession>
    <name>A0A2G1XLA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000106">
        <property type="protein sequence ID" value="PHQ52012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52012">
        <property type="protein sequence ID" value="PHQ52012"/>
        <property type="gene ID" value="BLA24_10085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="108" mass="11184" checksum="C985DF909677078D" modified="2018-01-31" version="1">MAALVLMDGYPSVPTGSPTEADASPGDPGTVREVFESLGHDPAAAAAPDSPLALLGEGKLEAVTRVFTDNARMLDVFTPGVFDGSVLLIEATKGRRTPHRGPRRGGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLD3</accession>
    <name>A0A2G1XLD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF881 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09835</name>
        <name evidence="4" type="ORF">CYQ11_04255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52053">
        <property type="protein sequence ID" value="PHQ52053"/>
        <property type="gene ID" value="BLA24_09835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16345">
        <property type="protein sequence ID" value="PPT16345"/>
        <property type="gene ID" value="CYQ11_04255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="239" mass="25853" checksum="4456D746B42A45DD" modified="2018-01-31" version="1">MTGRQRLKKGLWPPRLTRAQLTVAVLLCVLGLGLAIQVRSTSDNSALRGARQEDLVRILDELDNRTKRLEDEKRRLENQRTELESSSNQAAEARKQTAQKEEQLGVLAGTVAAQGPGIELTVSDPKGAVEADKLLDAIQELRAAGAEAIQINDVRVVADTYLSGSAGKVEIDGKKVSQPYKFKVIGKPQDLEPALNIPGGVVQTLEKGQAGVSVSRSEKIVVDALRPAKRPDYARSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLI5</accession>
    <name>A0A2G1XLI5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF881 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_09825</name>
        <name evidence="5" type="ORF">CYQ11_04265</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52041">
        <property type="protein sequence ID" value="PHQ52041"/>
        <property type="gene ID" value="BLA24_09825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12218">
        <property type="protein sequence ID" value="PPT12218"/>
        <property type="gene ID" value="CYQ11_04265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="293" mass="30617" checksum="88AF2B3A59118E13" modified="2018-01-31" version="1">MSQQPPVRSTSSPPPRPDASMSLLTNVMDHSLDDGYAEAAARRAEGDKGLPGTLRAKLGVAGALLLAAVVVTLGAAQARISAPTLAKERQQLIGRIEAETSAADTLQKNVDTLRDSVGNKQRDALRKHGGDKAELVSLLAGATTVHGPGIKLVVDDAKQAKSGSGGPRENTGFSDTGRVRDRDMQRIVNGLWQSGAEAISVNGQRLTALSAIRAAGDAILVDNKPLVPPYTVLAIGDGQRLSTAFQDSADGQYLHVLQQNYGVRASISAQDEVRLPPAPSLIVRTAKPGKGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM1</accession>
    <name>A0A2G1XLM1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09340</name>
        <name evidence="4" type="ORF">CYQ11_27950</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52116">
        <property type="protein sequence ID" value="PHQ52116"/>
        <property type="gene ID" value="BLA24_09340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16196">
        <property type="protein sequence ID" value="PPT16196"/>
        <property type="gene ID" value="CYQ11_27950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305603" evidence="1">
        <location>
            <begin position="29"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="404" mass="43443" checksum="578CC343EB9DBFCA" modified="2018-01-31" version="1">MTLRMVRRALTAALATVTLTATALTATASAGTDRRGGRHDATRAVMEAEVKAGTPGILGQVQDTYGTWNASAGVADLATHRQRLPRDRFRIGSVTKVFVSTVLLQLEAEGRIRLDDTVERWLPGLVHGNGHDGSRITVRQLLNHTSGISNYTEDPAFRKIISTGFSEHRYDTYTPDELVAVAMTHRPDFEPGKGWHYSNTNYIVAGMIVEKASGRDYATEIRERVIDRLGLRSTTLPGTSPRMPSPHGRAYSKLFATAPDAKIHDTTELNASWGGAAGEIISTTGDLNRFYRALLGGELLPERQQRELQTTVPTGDGTIGDGYGLGIAWSTLSCGRTVWFHSGGIHGSTSLASATPGGGHTAAFNLNSDWRGDLPALLEAEYCGSAPAAATESTKSLARLTALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLT9</accession>
    <name>A0A2G1XLT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08545</name>
        <name evidence="3" type="ORF">CYQ11_03800</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52208">
        <property type="protein sequence ID" value="PHQ52208"/>
        <property type="gene ID" value="BLA24_08545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12141">
        <property type="protein sequence ID" value="PPT12141"/>
        <property type="gene ID" value="CYQ11_03800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="169" mass="17259" checksum="AB00E0FEA7C38F3F" modified="2018-01-31" version="1">MTSPRSTYGGGYYASSSFPDTPIYDSLVAERGTPQIAPIRVSSPYDFGGGHLGGGGNPGGGNLPALPALPSGPSSHPAPQAQQHGYAAQAQQYGGQPAPAQPMGLQQAHAPHIPQQGAPRGYAGPPQQQRPAAAPAGPAGYDAMRPAAPRPSGQYEDPYGNRPYDQGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM04</accession>
    <name>A0A2G1XM04_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08910</name>
        <name evidence="4" type="ORF">CYQ11_04165</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52268">
        <property type="protein sequence ID" value="PHQ52268"/>
        <property type="gene ID" value="BLA24_08910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12200">
        <property type="protein sequence ID" value="PPT12200"/>
        <property type="gene ID" value="CYQ11_04165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="60"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="20946" checksum="22B60DDCAD46D894" modified="2018-01-31" version="1">MRFHGHGHEHHGPGPYGPPGFGGRRAFGPFGPPFGGPPFGGRGRGGPGGRARRGDVRASILALLKDRPMHGYEMIREIAERSGGAWKPSPGSVYPTLQLLEDEGLIASESEGGKKLFTLTESGRAEADAGPATPWEDVGRGVDWEAMQEIRQAGFGLMEAFGQVWKTGSAEQREKALAVINETRKKLYLILADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMC7</accession>
    <name>A0A2G1XMC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07600</name>
        <name evidence="3" type="ORF">CYQ11_00030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52405">
        <property type="protein sequence ID" value="PHQ52405"/>
        <property type="gene ID" value="BLA24_07600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16250">
        <property type="protein sequence ID" value="PPT16250"/>
        <property type="gene ID" value="CYQ11_00030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008868">
        <property type="entry name" value="TniB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05621">
        <property type="entry name" value="TniB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="39158" checksum="C9DADCC7554EF7AF" modified="2018-01-31" version="1">MNASPGTSDASARRSPRAADRSPSAAASTADDTPDPQQRSVTTWDGFQAFATTPVAAPPPPGAPRRSLEERLAYHSRFVTVRTPAIDALAKNVRTLMVLGRHQAVTARPSLIVTGPAGAGKTTALLQVGRACHLAHTRRHGPAATAGQAPVAYVLVPPAASAKTLAIEFARYLGTPVTAGMSQAQITGAVCHTYTAARVQLVMIDEIHRLNPRTTTGAQSADLIKDLTERIGATFVYAGIDVTTTPLFTGVRGAQLAGRASLIDCAAFPARLGDEEPFRDLITAMESALDLRHHQPGTLPRLAPYLHERTAGRIGSLARLIRQAAITALLDGTERITKTTLAAIRLDHLAEQHYQPRARPRSRNTNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XME2</accession>
    <name>A0A2G1XME2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08020</name>
        <name evidence="4" type="ORF">CYQ11_00455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52383">
        <property type="protein sequence ID" value="PHQ52383"/>
        <property type="gene ID" value="BLA24_08020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11585">
        <property type="protein sequence ID" value="PPT11585"/>
        <property type="gene ID" value="CYQ11_00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758884" evidence="2">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="124" mass="12306" checksum="2A464F06DCAB8EF0" modified="2018-01-31" version="1">MSSMRSRVAAVMLAVAAGGAVLGQASTAMADDHHRHGHDDGLGPLPIAIVSPAPGKITKERKITDTYTYDAKGGSSSSSQEQPPPSSSPSQPEPGPVTALKDTANSAAQAVTSGAGATVDAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMF6</accession>
    <name>A0A2G1XMF6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiazolylpeptide-type bacteriocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06525</name>
        <name evidence="2" type="ORF">CYQ11_26670</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52435">
        <property type="protein sequence ID" value="PHQ52435"/>
        <property type="gene ID" value="BLA24_06525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15967">
        <property type="protein sequence ID" value="PPT15967"/>
        <property type="gene ID" value="CYQ11_26670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023895">
        <property type="entry name" value="Thiopep_bacteriocin_prcur"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03892">
        <property type="entry name" value="thiopep_precurs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="52" mass="5473" checksum="1AC31DA93780CAC4" modified="2018-01-31" version="1">MNNDILEMDELDFQLEELSVLDIADARALPELGASNGSIGCSSSTCSSTCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMW8</accession>
    <name>A0A2G1XMW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07020</name>
        <name evidence="3" type="ORF">CYQ11_27175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52521">
        <property type="protein sequence ID" value="PHQ52521"/>
        <property type="gene ID" value="BLA24_07020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16057">
        <property type="protein sequence ID" value="PPT16057"/>
        <property type="gene ID" value="CYQ11_27175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="275" mass="28494" checksum="252D9F2E9053E593" modified="2018-01-31" version="1">MSSVEESRTPRTAPRSGPPPRPAPHALLSGRTAVVTAAAGTGIGGATARRFLEEGAAVVLGDAHERRLRATVTALAGEFGAGRVAGTPCDVTDEGQVAALLDLARARHGPLDVLVNNAGLGGTAELADMTDEQWHRVLDTTLNGTFRCTRAALRRMRADGTGGVVVNNASVIGWRAQRGQAHYAAAKAGVMALTRCAAVEAAAYGVRVNAVAPSLAAHPHLARVTTPGLLAELAEREAFGRAAEPWEVANVIVFLASDYSSYMTGETVSVSSQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX9</accession>
    <name>A0A2G1XMX9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_07280</name>
        <name evidence="11" type="ORF">CYQ11_27435</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52563">
        <property type="protein sequence ID" value="PHQ52563"/>
        <property type="gene ID" value="BLA24_07280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16101">
        <property type="protein sequence ID" value="PPT16101"/>
        <property type="gene ID" value="CYQ11_27435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="356"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="389"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="598" mass="64696" checksum="8BC0E852187139DF" modified="2018-01-31" version="1">MPHDELDWTPPPADPEQPAQVRRILRLFRPYRGRLGLVGLLVAASSLVTVASPFLLREVLDVAIPQGRTGLLTLLALGMIAAAVVNSVFGVLQTLISTTVGQRVMHDLRTAVYGRLQTMPLAFFTRTRTGEVQSRIANDIGGMQATVTSTATSLVSNLTSVIATVVAMVALDWRLTVVSLLLLPLFVWISRRVGDERKRITAKRQSQMAAMAAMVTESLSVSGILLGRTMGRSDSLTKAFAQESERLVALEVRTNMAGRWRMSTIGIVMAAMPALVYWAAGMALKTGGPDISLGTLVAFVSLQQGLFRPTVSLLSTGVQMQTSLALFQRIFEYLDMPVDITEPEHPVRLDKISGEVRFENVSFSYDPANPALTGIDLMVPAGGSLAVVGPTGSGKSTLSYLVPRLYDVTAGRVLLDGTDVRDLDFDTLARAVGVVSQETYLFHASVAENLRFAKPDASDEELRAAAEAAQIHDHIASLPEGYDTLVGERGYRFSGGEKQRLAIARTILRDPPVLILDEATSALDTHTEHAVQQAIDALSAGRTTITIAHRLSTVRHADQIVVLRGGRIAERGTHQELLAGDGHYAALVRRDTHLTVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN27</accession>
    <name>A0A2G1XN27_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000074">
        <property type="protein sequence ID" value="PHQ52652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52652">
        <property type="protein sequence ID" value="PHQ52652"/>
        <property type="gene ID" value="BLA24_06225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="96" mass="9829" checksum="FA57FE70FE3BB75B" modified="2018-01-31" version="1">MRSWSSAGNPARAMTTLFASGRAYACTRSTGGSAGTSSARRPAISSIRGSRSRAPFAEKYGTTGLRSRSCAGDPSKPMLGAVNVLVLARTSRTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN47</accession>
    <name>A0A2G1XN47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylaspartate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06090</name>
        <name evidence="2" type="ORF">CYQ11_03615</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52672">
        <property type="protein sequence ID" value="PHQ52672"/>
        <property type="gene ID" value="BLA24_06090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12106">
        <property type="protein sequence ID" value="PPT12106"/>
        <property type="gene ID" value="CYQ11_03615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="163" mass="16938" checksum="87934FE608AE7317" modified="2018-01-31" version="1">MTPAGGLDVVVSGTESDSHTWNLVYLQLLLEDWGHRVENAGPCIGGADLVTRYAYRAPDLLVLSSVNGHGESDGLRAIAALRTAPELAATPIVIGGKLGTRGVTADGAHGGGAEQVTRRLLAAGFSAVFLDPVDLQGFQDFVRAVAGHRARTNRGVLATSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN66</accession>
    <name>A0A2G1XN66_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_06170</name>
        <name evidence="6" type="ORF">CYQ11_03695</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52687">
        <property type="protein sequence ID" value="PHQ52687"/>
        <property type="gene ID" value="BLA24_06170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12121">
        <property type="protein sequence ID" value="PPT12121"/>
        <property type="gene ID" value="CYQ11_03695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="160"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="319" mass="33899" checksum="F1998E47B401E455" modified="2018-01-31" version="1">MGDTPLRQGPGPERGLFSLAELPPPLIQGLTARSVELFHDPRAHDRPLAAQVVGVLFTRTSTRTRTAFTVATLRLGGSPVGFGPGDLQLNTGETVGDTGRVLGSMLDLLVARTAGPLDELRNLSRSGRLPVVNAMAAQEHPSQGLCDLATLALTFGDLTGIQVLYVGEGNNTAVALAHGLAAVPGARVTFATPAGYGLPEDELRTAERRAGTVGAAVEQIHELAAAPADVDVVYTTRWQTTGTVKPDPDWREAFRPFHVDEHLLDRWPRASFMHDLPAHRGDEVSGRVLDGPRSLAWTQAAMKLSSAMAVLEWAAGPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN75</accession>
    <name>A0A2G1XN75_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_06030</name>
        <name evidence="5" type="ORF">CYQ11_03555</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52697">
        <property type="protein sequence ID" value="PHQ52697"/>
        <property type="gene ID" value="BLA24_06030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16330">
        <property type="protein sequence ID" value="PPT16330"/>
        <property type="gene ID" value="CYQ11_03555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="191" mass="20616" checksum="A10EF9AA798C541A" modified="2018-01-31" version="1">MRESAVHNTTGRHGPAPDTAGTAPAAPRLRPPAHPVDPRAITWWTWQAVLTVLGFLACVAGLELWLWKKTPLPLSVGVIALSLLLSVAYVLIVPSWRFRVHRWETTGEAVYTASGWLWQVWRVAPMSRIQTVDTARGPLQQMLGLATVVVTTASAAGPVRIHGLSHDLAKEVVDHLTATTQATQGADGDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN98</accession>
    <name>A0A2G1XN98_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4865 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05460</name>
        <name evidence="2" type="ORF">CYQ11_01920</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52722">
        <property type="protein sequence ID" value="PHQ52722"/>
        <property type="gene ID" value="BLA24_05460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11816">
        <property type="protein sequence ID" value="PPT11816"/>
        <property type="gene ID" value="CYQ11_01920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032349">
        <property type="entry name" value="DUF4865"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16157">
        <property type="entry name" value="DUF4865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="202" mass="22382" checksum="8D60C926F0195B65" modified="2018-01-31" version="1">MYAKQYEVTLPADYDMRIIRKRVADFGHILDDRAGLGLKAYVIRERGVEGSPVNQYAPFYLWADTAAMSEFLVGGGGFQGIIRDFGRPVVHHWTGISSEAGPARNTTPKAASRRVTRLPADSGTAGTGLADLIRREADALHALAQRDGVHTAALAVDPHHWELMRFVLWEDAVPETEDATERYEVLHLSAPHLADLPEGRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNF6</accession>
    <name>A0A2G1XNF6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05395</name>
        <name evidence="3" type="ORF">CYQ11_01855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52711">
        <property type="protein sequence ID" value="PHQ52711"/>
        <property type="gene ID" value="BLA24_05395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11805">
        <property type="protein sequence ID" value="PPT11805"/>
        <property type="gene ID" value="CYQ11_01855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="183" mass="20954" checksum="CE5177DE34C4024D" modified="2018-01-31" version="1">MFSLPLRDDARLRPLETWHAEEFAAHLDRAREHIRPWVGPAFVTDDVDGARATIRRYAERQATDGARLYGIWLDDVLVGGVMFTDFDAAWGSCEVGCWLEPAAEGRGLITEACRALLDWAFTTRGLHRAEWHCRADNDRSYAVAERLGMVLEGVRREAWPFEGARYDKQIWGVLASEWRAHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNK5</accession>
    <name>A0A2G1XNK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05920</name>
        <name evidence="3" type="ORF">CYQ11_02395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52796">
        <property type="protein sequence ID" value="PHQ52796"/>
        <property type="gene ID" value="BLA24_05920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11898">
        <property type="protein sequence ID" value="PPT11898"/>
        <property type="gene ID" value="CYQ11_02395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304756" evidence="1">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="18196" checksum="73A845492C208375" modified="2018-01-31" version="1">MRTTARKAAGAGAAMALAAATLVTGAGAASAAPAEAAATCGTSGLRASLADKSPGGQSGMSHEGTVLTLTNTSDHTCALRGYPGLGLEDARHGPLETHTSWGSTYFIPDPGKQTLRLRPGESAEAGLAWAHADAPTMVQARYLEITPPASRDHLTVPFDKTVTNGDLSVTAFARTVDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNL5</accession>
    <name>A0A2G1XNL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CsbD family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">General stress protein CsbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05975</name>
        <name evidence="5" type="ORF">CYQ11_02450</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52806">
        <property type="protein sequence ID" value="PHQ52806"/>
        <property type="gene ID" value="BLA24_05975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11908">
        <property type="protein sequence ID" value="PPT11908"/>
        <property type="gene ID" value="CYQ11_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6714" checksum="E66A78C0C8AD9ADA" modified="2018-01-31" version="1">MSAKDKAKAKAEKMKGRAKQTTGRATGDKHTQDVGRLERAKGEVRDAVEKVRHSTKGKHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNQ4</accession>
    <name>A0A2G1XNQ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_04535</name>
        <name evidence="8" type="ORF">CYQ11_28990</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52846">
        <property type="protein sequence ID" value="PHQ52846"/>
        <property type="gene ID" value="BLA24_04535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11497">
        <property type="protein sequence ID" value="PPT11497"/>
        <property type="gene ID" value="CYQ11_28990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="227"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="421" mass="43377" checksum="D16E61ECFC8404AB" modified="2018-01-31" version="1">MLSVKASDGAGPLRNHDFRLLLAGASVSQIGAQVTLVALPLVAVVELEASPLQAGMLTAAETGAFLIVGLPAGAWVDRMRRLPVLVRADVVRAVAMASLPLAAWAEVLTMTQLYAVALVTGLATVFFDIAHQSYLPVLLPREQLVAGNGALETARSSAQVAGPGLGGALVQALGAPFALMADAVGYLLSAFFLRGIRAHEERPEPVVGVSLRAQVGEGLAFVLRHPVLRVIACATAVSNFFTAMLMAVQTVFLVRVLGLPPGVIGLMMSAAAVGGLAGALCAGVLSRAVGQARVIWLSTVVTGPFALLWPLAGRGAAAAWFALATAAVFFGGVVYNVAQVSFRQMLCPPELLGRMNATLRFLVWGTMPLGAVVGGAVAGTAGPRDAVWLCAAGILLVPVPLLLSPLRRMRDLPAPAGTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNU7</accession>
    <name>A0A2G1XNU7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04640</name>
        <name evidence="4" type="ORF">CYQ11_28890</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52861">
        <property type="protein sequence ID" value="PHQ52861"/>
        <property type="gene ID" value="BLA24_04640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11480">
        <property type="protein sequence ID" value="PPT11480"/>
        <property type="gene ID" value="CYQ11_28890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304751" evidence="2">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="16819" checksum="85FB88B0E53A670C" modified="2018-01-31" version="1">MPSLATRRRCAGAACAAGMLILTPVPAGAATPAPATVVVRCSGAFTMTAGGFTGAAQGRGELTCAVPGRPEPTSATLRMRGSFSGRATAVTTATEDTLTFDTGQVTRFSATRTFVTDAGRLAETGEGVSTSGDHHPATATESGRGTTRSGGDVTVFTVDDGFTLELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP68</accession>
    <name>A0A2G1XP68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04090</name>
        <name evidence="4" type="ORF">BLA24_04105</name>
        <name evidence="2" type="ORF">BLA24_17845</name>
        <name evidence="5" type="ORF">CYQ11_15430</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000062">
        <property type="protein sequence ID" value="PHQ53038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000062">
        <property type="protein sequence ID" value="PHQ53039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50657">
        <property type="protein sequence ID" value="PHQ50657"/>
        <property type="gene ID" value="BLA24_17845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53038">
        <property type="protein sequence ID" value="PHQ53038"/>
        <property type="gene ID" value="BLA24_04090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53039">
        <property type="protein sequence ID" value="PHQ53039"/>
        <property type="gene ID" value="BLA24_04105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14088">
        <property type="protein sequence ID" value="PPT14088"/>
        <property type="gene ID" value="CYQ11_15430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="343" mass="37825" checksum="653878E8687D3B44" modified="2018-01-31" version="1">MALTLYVDTARWRAHQQSVLQQFPGIIPVCKGNGYGFGHERLSDEATRMGADILAVGTTYEAARIKDFFSGDLLVLTPFRLGEEPVPLPDRAIRSVSSVEGVRGLVGARVVVEVMSSMKRHGISEEDLPKLHAAIEDVRLEGFAIHLPLDRGDGTGAVDEVTGWMERLRNAHLPLHTMFVSHLKSEELRELQQRFPQTRFRARIGTRLWLGDHDATQYRGAVLDVTPVAKGDRFGYRQQKAAGDGYLVVVAGGTSHGVGLEAPKALHGMMPRAKGVARAGLATMNRNLSPFVWAGKQRWFAEPPHMQVSILFVPADAPAPQVGDELVAHLRHTTTQFDRIVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPD5</accession>
    <name>A0A2G1XPD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_03600</name>
        <name evidence="2" type="ORF">CYQ11_23255</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000047">
        <property type="protein sequence ID" value="PHQ53094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53094">
        <property type="protein sequence ID" value="PHQ53094"/>
        <property type="gene ID" value="BLA24_03600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15408">
        <property type="protein sequence ID" value="PPT15408"/>
        <property type="gene ID" value="CYQ11_23255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="233" mass="24325" checksum="3615041536D5C280" modified="2018-01-31" version="1">MGTQEKLAAAGVGPGDEVIVPSYGPSEPAEAVRNAGALPVFADIDPVTFCLDPASVADAVSRRTAAIVPVHLFGHLADLAALQSLACRDGLLLVAPDAPEEGTGGTAGSAVDSRRANAAFLGARLTGVVTPSAAPGVRHRYESYVVRVPGNGRPDRDAFARALRARGIHCRVPVQTPVHRMPLFRQELWLTETERAADECLALPVDAGMSRRELHRVVSACNALGGLMPVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPM0</accession>
    <name>A0A2G1XPM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02275</name>
        <name evidence="3" type="ORF">CYQ11_04635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53187">
        <property type="protein sequence ID" value="PHQ53187"/>
        <property type="gene ID" value="BLA24_02275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12279">
        <property type="protein sequence ID" value="PPT12279"/>
        <property type="gene ID" value="CYQ11_04635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="110"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="419" mass="44941" checksum="803A295443DBF325" modified="2018-01-31" version="1">MVNPWLAMTCGGDPAERCRSVRSAHAAFLTGGLVAPDVREVVADSWRRSAAVLPAGEFLAPVELAGAELEEYRRTHPLARAMPLLRELLGSIADDGAHLLAVSDASGRLLWVEGHRGVRGRAERMNFVAGARWDERHAGTNAPGTALALGHAVQIFATEHYNRLVQPWTCVAAPLRDPGSGRLLGTVDITGGDHLAGPHSLALVRATARAAEAQLASGSARPGHVLSVLGRDEALLVTDGRRLRLGRRHSEILLLLAGRPEGLTGDQLTWELYGERPVPPVTLRAELSRLRRLVGGLLGSRPYRLSVPVQTDAACVERELAAGDLRAALRAYEGPPLPLSEAPGVCRTRRLLEDRLRRAVLGGGDAGALQMWADSPWGEDDLEVWERLLAALPESAGHRGAVAARARRLRATFAQPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ38</accession>
    <name>A0A2G1XQ38_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_02800</name>
        <name evidence="5" type="ORF">CYQ11_05095</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53259">
        <property type="protein sequence ID" value="PHQ53259"/>
        <property type="gene ID" value="BLA24_02800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12352">
        <property type="protein sequence ID" value="PPT12352"/>
        <property type="gene ID" value="CYQ11_05095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="156" mass="16393" checksum="32AC3D4787E48400" modified="2018-01-31" version="1">MTVRRGRRIAVDVGDARIGVASCDPDGILATPVETVPGRDIPQAHKRLAAIVAEYEPIEVVVGLPRSLKGGEGPAAAKVRTFAKEMARRVAPVPVRLVDERMTTVTAAQGLRASGVSAKKGRSFVDQAAAVVILQNALEIEKVSGRPPGEAVEVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ84</accession>
    <name>A0A2G1XQ84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_01385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000021">
        <property type="protein sequence ID" value="PHQ53396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53396">
        <property type="protein sequence ID" value="PHQ53396"/>
        <property type="gene ID" value="BLA24_01385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="237"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="402" mass="42590" checksum="384E34CE38A4111C" modified="2018-01-31" version="1">MPEPSLASSAGRRGASDTAKDGSGKSQGQVDAAAAKDASKAQIKITPKGGTTDAGISTDAVQVTVSDGELTSVKMTTEKGTPVEGSISSDKKTWKPNSQLERSTKYKVVAEAKDDKGRKATENSSFSTVSPANSFIGAFTPEDGSTVGVGMPVSINFNKPIKDRKAVQSHLEVTSSSGQKVVGHWFGDQRLDFRPQDYWKANSQVTLKMNLDGVEGAPGIKGVQNKTINFKIGHAQVSTVDAKTHKMTVTRDGQVVKTIPISAGSPSNPTYNGKMVISEKFKETRMDGSTVGFSKADGKGEYDIKDVPHAMRLSTSGTFIHGNYWGSGVFGVANTSHGCVGLEDKQGADDPNTPGSWFFSNSILGDVVEVKNSDDKTIAPDNGLNGWNMDWNQWVQGSATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQR9</accession>
    <name>A0A2G1XQR9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="8" type="ORF">BLA24_00780</name>
        <name evidence="9" type="ORF">CYQ11_07790</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53499">
        <property type="protein sequence ID" value="PHQ53499"/>
        <property type="gene ID" value="BLA24_00780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12804">
        <property type="protein sequence ID" value="PPT12804"/>
        <property type="gene ID" value="CYQ11_07790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="319" mass="34560" checksum="9AE9FA8BDE66FEA0" modified="2018-01-31" version="1">MSSNARHVPVMLQRCLDMLAPALAEPGAVVVDCTLGAGGHSEALLKRFPEVRLVALDRDPTALKLAGERLAPYGDRATLVRAVYHELPEVLERLGIPRVQGVLFDLGVSSMQLDEADRGFAYAQDAPLDMRMDQTTGISAAEVLNTYPPGELVRILRAYGEEKQAKRIVSAVVREREKEPFSNSARLVELIRDALPQAAKRTGGNPAKRTFQALRIEVNAELASVEQAIPAAVAALAVGGRIAVLSYQSLEDRIVKSVFAAGATSTAPPGLPVVPEQYQPRLKLLTRGAELPTEEEVAENRRAAPARLRGAERIREDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9N6</accession>
    <name>A0A2G1X9N6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_31030</name>
        <name evidence="5" type="ORF">CYQ11_24130</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47936">
        <property type="protein sequence ID" value="PHQ47936"/>
        <property type="gene ID" value="BLA24_31030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15561">
        <property type="protein sequence ID" value="PPT15561"/>
        <property type="gene ID" value="CYQ11_24130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="178"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="31680" checksum="4EF34FD1DC13F161" modified="2018-01-31" version="1">MAPGRAARTRRGGVAAASAAPPPKERGRPRTGAFLVLLAGVLWGTMGAAQKVPDQMGGVASTGAFRTLLGGVCLLVAAGRAARPRRSPGARSLGALLLGGVSVGAFQILFFASMRHIGVAMGTVLTIGSSPVFAGLIVWVRTRRRPATHWWVATATTVLGCALLNGGAPSGSAGSPAPGIAMALAAGASYALFAVVSKPLIAAAPAQVVMGWMLLVAAVVLLPFALRDDLSWLAATDGLAVALYLGVVTTAGGFLVFGLGLRWVSPTTAATLSLVEPLTAAVLGFGLLGEPLTAAMLAGVCLLFAGLAWTALRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9V5</accession>
    <name>A0A2G1X9V5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">3' terminal RNA ribose 2'-O-methyltransferase Hen1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_31285</name>
        <name evidence="12" type="ORF">CYQ11_24325</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47949">
        <property type="protein sequence ID" value="PHQ47949"/>
        <property type="gene ID" value="BLA24_31285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15573">
        <property type="protein sequence ID" value="PPT15573"/>
        <property type="gene ID" value="CYQ11_24325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024026">
        <property type="entry name" value="3'-RNA_MeTfrase_Hen1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024740">
        <property type="entry name" value="Hen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038546">
        <property type="entry name" value="Hen1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="PTHR21404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12623">
        <property type="entry name" value="Hen1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04074">
        <property type="entry name" value="bacter_Hen1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hen1_L" evidence="10">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_12" evidence="9">
        <location>
            <begin position="302"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="503" mass="55378" checksum="5702DBC7D2AADA34" modified="2018-01-31" version="1">MFLTISTTGTPENPATDLGFLLHKHPEKAQRFSTSHGTAHVLYPEAGVERCTAALLLEVDPVALVRRGKGKERGGPADPTLAQYVNDRPYAASSLLAVALGSVFSSAVKGQCAARPELPGRARPLRVEVPALPARGGAALIARLFEPLGWTVTARPVALDERFPEWGESRYVSLVLEGELRLADALRHLYVLLPVLDDAKHYWVAPDEVEKLLRSGEGWLEDHPEQRLITSRYLSRRWSLTRDALERLALARLAEADDSRAEELDNAVDEKDDTEERPQPLAVRRREAVVAALRASGAARVLDLGCGQGQLVGALLQDTRFTEIVGVDVSVRALKEAARRLRLDRMTERQSARVTLLQGSLAYTDRRLAGYDAAVLSEVVEHLDLSRLPALEYAVFGAARPGTVVVTTPNAEYNIRWETLPAGHVRHADHRFEWTREEFRAWADRVAGRHGYAVEFTPVGADDPEVGPPTQMAVFRRNDTGNAPQGTDGERGTDETAKEEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Y3</accession>
    <name>A0A2G1X9Y3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cysC</name>
        <name evidence="3" type="ORF">BLA24_31765</name>
        <name evidence="4" type="ORF">CYQ11_24820</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48032">
        <property type="protein sequence ID" value="PHQ48032"/>
        <property type="gene ID" value="BLA24_31765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15658">
        <property type="protein sequence ID" value="PPT15658"/>
        <property type="gene ID" value="CYQ11_24820"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="178" mass="18925" checksum="A321C03758C535E4" modified="2018-01-31" version="1">MSVGATVWLTGLPSAGKTTIARALAGRLRGVGGRVEVLDGDEVREFLSAGLGFSREDRFVNVERIGFVAQLLASHGVLVLVPVIAPYADAREAVRERHRVRGTGFVEVHVATPVEVCAVRDVKGLYARQAAGRLSGLTGVDDPYEVPVAPDLRIAAHEQGVEESVAALHVLLSERGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA90</accession>
    <name>A0A2G1XA90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32550</name>
        <name evidence="5" type="ORF">CYQ11_25600</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48157">
        <property type="protein sequence ID" value="PHQ48157"/>
        <property type="gene ID" value="BLA24_32550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15783">
        <property type="protein sequence ID" value="PPT15783"/>
        <property type="gene ID" value="CYQ11_25600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="30773" checksum="0CFBA00CDC1BCAC3" modified="2018-01-31" version="1">MSQPAKSARAPRGAAAEPRGAKGPKGSREPAETGTESAGSRRAAAQRLTMRRKLAAAAMELFATKGYEATTVDEIAATAGVARRTFFRHFRSKEEAIFPDHDDTLVRAAGVLDAAPPHENPLDTVCRGIKEVMRMYAASPAVSVERYRLTREVPALREREIASVARYERLFTRYLLGHFDETAHHVGDDDPLLAEVAASAVVTAHNHVLRRWLRGGGQGDVEAQLDHAFAIVRETFGSGIGAGREAEAAPAATARTEGEVLVTVARTDAPLDEVMRAIEKALKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA93</accession>
    <name>A0A2G1XA93_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32510</name>
        <name evidence="7" type="ORF">CYQ11_25560</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48150">
        <property type="protein sequence ID" value="PHQ48150"/>
        <property type="gene ID" value="BLA24_32510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15776">
        <property type="protein sequence ID" value="PPT15776"/>
        <property type="gene ID" value="CYQ11_25560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="38807" checksum="CB74068DC0C2FF94" modified="2018-01-31" version="1">MGSATVPRVGSPRRDPEARGCTVAEATRVLIAADKFKGSLTAAQVAGHVAAGLRRAAPTADVTALPVADGGDGTVDAALAAGFARREAAVTGPLGEPVVAAYALRAADGTAVVEMAGASGLRLLPGGRSAPLTATTYGTGELLRAALDAGARTIVLGVGGSATTDGGSGMLAALGGRLADGAGRPVGPGGAALAALAEADLSGLDERLARTRVVLASDVDNPLTGPRGAAAVYGPQKGASPADVEVLDAALAHYAAVLDGGERAAEPGAGAAGGTGYGALVGLGAAFRPGIEVMLDVLGFETALEGAGLVITGEGSLDEQTLHGKAPVGVARAARARGVPVVAVCGRLALDAAALAGAGIERAYALTDLEPDPRRCMAEAGPLLERLAERVARDHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC7</accession>
    <name>A0A2G1XAC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32570</name>
        <name evidence="2" type="ORF">CYQ11_25620</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48161">
        <property type="protein sequence ID" value="PHQ48161"/>
        <property type="gene ID" value="BLA24_32570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15787">
        <property type="protein sequence ID" value="PPT15787"/>
        <property type="gene ID" value="CYQ11_25620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014488">
        <property type="entry name" value="UCP017371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017371">
        <property type="entry name" value="UCP017371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="152" mass="16303" checksum="8AB86093191CAD11" modified="2018-01-31" version="1">MGQVEASTERIIAAGAEDVFDALADYSDTRAKLLPEHFSEYEVREGGDGEGTVVHWKLQATSKRVRDCLLEVSEPSTGQLVERDRNSSMVTTWTVTPAGEGKAKVVVTTTWKGAGGVGGFFERTFAPKGLARIYDAVLDKLAAEVEGRPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAM5</accession>
    <name>A0A2G1XAM5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33180</name>
        <name evidence="3" type="ORF">CYQ11_26230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48262">
        <property type="protein sequence ID" value="PHQ48262"/>
        <property type="gene ID" value="BLA24_33180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15893">
        <property type="protein sequence ID" value="PPT15893"/>
        <property type="gene ID" value="CYQ11_26230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="36053" checksum="E168DE5F6E500540" modified="2018-01-31" version="1">MQLPRLESRCKFGAMDGDRTTKWGEGTAADLVADAHSLGVMKASPRMVTSWVEDGMLASPEPRKTSPHGSDPRVFPPEQRELFTRLLEARERSPLGRIPQRSLIRVVLYLWLIDDTIVHTPQARRAWRTHARATGQTTAVRRGKNVRAIVEQLAHPSATLKQRRVAQLVLEEGERTGRIDIGKLTAVLTELYSPWPVQPGMPRIERALPGPFGPVSVQHHIAMWKAREQTFRRLRHEEIDENELDRVRAVYRPMWADYQARRPAMATIGDGEFAAYFAEPDTMEGRAIKAVDAFVGTLAGELGLIEAAAHAAETARLRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAS6</accession>
    <name>A0A2G1XAS6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">treZ</name>
        <name evidence="14" type="ORF">BLA24_31675</name>
        <name evidence="15" type="ORF">CYQ11_24730</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48347">
        <property type="protein sequence ID" value="PHQ48347"/>
        <property type="gene ID" value="BLA24_31675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16773">
        <property type="protein sequence ID" value="PPT16773"/>
        <property type="gene ID" value="CYQ11_24730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="13">
        <location>
            <begin position="98"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="242"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="378"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ48347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT16773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="597" mass="63765" checksum="328C0513F99DCEE9" modified="2018-01-31" version="1">MLFEVWAPRAGQVTLWADGGTYAMAPGPAGTGWWRCEAPGTEGTRYGFRLDGGPPLPDPRSRRQPDGPDGTSAVVDVSRFAWRHAWPGRPLPGAVLYELHVGTFTREGTFEAAAAKLPHLAELGVTHVEVMPVCPFPGRHGWGYDGVAPWAVHEPYGGPEGLARFVDAAHGRGLGVVLDVVHNHLGPSGNHLPSFGPYFTDAHHTPWGAAVNLDGPGSAEVRAYLTASALAWLRDYRLDGLRLDAVHALADTSPEHFLAELSAAVDDLAARLGRPLFLVAESDRNDPATTTPREAGGLGLHAQWNDDFHHALHTALTGESQGYYADFAADPAAALGKTLRSGFFHDGAYSSFRGRRHGHPLDPGVTPAHRLLGYAQTHDQVGNRALGDRLSAALSPGLLACAAALVLCAPFTPMLFMGEEWGARTPWQYFTDHTDPGLAEAVRTGRRREFTAHGWPEEEIPDPQDPATRDRSCLDWAEPSREPHAALLAWYRRLIALRHTEPALTDPRWAYGDLSADARTVRFARGPLHVAVNLGAETAALRMGAAAAGAEVVAAWRPVPPPDAEGVLRLPPETAVVLRAGAAPAPPVAAATGAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAU8</accession>
    <name>A0A2G1XAU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32255</name>
        <name evidence="5" type="ORF">CYQ11_25310</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48364">
        <property type="protein sequence ID" value="PHQ48364"/>
        <property type="gene ID" value="BLA24_32255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16790">
        <property type="protein sequence ID" value="PPT16790"/>
        <property type="gene ID" value="CYQ11_25310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="375" mass="38301" checksum="4D22DD54B8B7DD91" modified="2018-01-31" version="1">MRHDGSPPPPPSAPTGPGSRRTSATDEAGPPSGPLPPGRLTAWLRRRLGWTVTAAYLTAVALPGPGLRLRHVHTVPLPGACLPLNVPSLLLALVLFSAGLQVPLGDLGRLLRRPLALLAGLALHLAAPLLVVPAVAFALQRSPDSDGGSGLITAMILIVAMPVAAGATVWTGKGDADQPVMVGLVLASTLLSPFTVPLTVHALSPLLGGDYAGTLDKAAYGAGNSFALTSVLLPCGAGILTRLFLPHRVMQPLLRATPAAALWGSLLLTYVNASGALGSFFTQPRPLLLAAALIVASAVCALSFALGRVTARLLRLDTPTGSSLTLACGMNNSSASAVLITTALPDRPHLLLPVLAYGFLQKLAAGRVVRASAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAZ0</accession>
    <name>A0A2G1XAZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress-inducible protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_33315</name>
        <name evidence="4" type="ORF">CYQ11_26365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48393">
        <property type="protein sequence ID" value="PHQ48393"/>
        <property type="gene ID" value="BLA24_33315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16815">
        <property type="protein sequence ID" value="PPT16815"/>
        <property type="gene ID" value="CYQ11_26365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="167"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="30700" checksum="8EC2A70CA165C9FC" modified="2018-01-31" version="1">MESAPITVGLDGSAESLAAALWAADEAERRGLGLRLLHAWVLLAGEPATGLPPDKDQNYWAKRIVRAAATAVYERHHDLSVTEDLVAEEPEAALLNAAVSSTMIVLGSRGLERLESFFLGDISLQVAGRAAQPVVLVRAPAGRARPLAGTDEGGVVVGASLHGRYDSVLGFAFETAAARGVPLRVVHGCPLPVQAYAPWGVDPEVAGEISKEASEKLSRAVQPWSERNPGVMTTSTVRLGSPARAVLGAAEDADLLVIGRRKHHPPVAPRLGNIAQACVHHARCPVAVVPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB92</accession>
    <name>A0A2G1XB92_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29510</name>
        <name evidence="3" type="ORF">CYQ11_05965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48498">
        <property type="protein sequence ID" value="PHQ48498"/>
        <property type="gene ID" value="BLA24_29510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12503">
        <property type="protein sequence ID" value="PPT12503"/>
        <property type="gene ID" value="CYQ11_05965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="27475" checksum="42036B08EBBAF713" modified="2018-01-31" version="1">MSDAAQPTAAEVRAAAEAVKTALDRHLEAVERRSGEDDPAVYAAFNELAATAEAYDELLYDAYDEVTPFEIPGDDTLPAYAGPEEPSALSVLIRRDYAVVEPQRLLAQAQRVADLDPDADTDTVPGTSGGALGLVGSSVHAALGVLFGEYEPDEIASRHKEFGLEEGDSTLWVAAADEPAEPGEWLSAPFDQADPQRVVCRFDVSAVFDEELDLDDEALDDESLEDESLEDEGLEDDGPADGPDAAGDDAGPPGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBB0</accession>
    <name>A0A2G1XBB0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29340</name>
        <name evidence="2" type="ORF">CYQ11_06135</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48469">
        <property type="protein sequence ID" value="PHQ48469"/>
        <property type="gene ID" value="BLA24_29340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12533">
        <property type="protein sequence ID" value="PPT12533"/>
        <property type="gene ID" value="CYQ11_06135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="205" mass="22964" checksum="061E1DCEA02FC6B7" modified="2018-01-31" version="1">MAGFRALAREVRNPRNTIALRRTSLRKCLERFAPYGHRATWRHLCARAGIAPDDRAPDPGRLIAALAELEEAREVWLAYEAEFAGRRRREKHDGIRQPSAVDDWHRNTWGGCDIVPCASPDVQPDARLADVLRRVITAMESAPGDACPVCAQERIEWRTDLERYPLQGPVCTDCGIVVPVSVLTPAALSAARRYTFTFAERYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBB9</accession>
    <name>A0A2G1XBB9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_29585</name>
        <name evidence="9" type="ORF">CYQ11_05890</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48510">
        <property type="protein sequence ID" value="PHQ48510"/>
        <property type="gene ID" value="BLA24_29585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12491">
        <property type="protein sequence ID" value="PPT12491"/>
        <property type="gene ID" value="CYQ11_05890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="26362" checksum="103659452304CF6A" modified="2018-01-31" version="1">MSSSDIFTGETIGTAVLILLGGGVCAAVTLKRSKALNAGWLAITFGWGFAVLAGAYIGAKSGAHLNPAVTVGLALDGAVEWSDVPLYIGSQLLGAMIGATLVWLTYMGQFKAHLTDPELVATLNPAEGMVDQTATPQAGPVLGVFSTGPEIRNAVQNLITEIIATAALVLFILTMGLTKGLAVSGTGTLMVALVVVGIGLSLGGPTGYAINPARDLGPRIVHALLPLPNKGGSDWGYAWIPVVGPIIGAALAAGIHKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH3</accession>
    <name>A0A2G1XBH3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_29970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48576">
        <property type="protein sequence ID" value="PHQ48576"/>
        <property type="gene ID" value="BLA24_29970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ48576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="220" mass="23619" checksum="F6A7561F3BCF6821" modified="2018-01-31" version="1">MLERTGERSPAGRRRGCPLSGRPPGAEAPDARPHRRRHRHRDDPARARHRAALGAARRRAGPCARRSALAGGTFLLSALVIALFWRAHHAALESAERIDVRLFWLNVAFLALVSLIPFPTSVLQNYGDRTLGPGLYGAVIGTVSLVVYAMEVHAHRLSAAPRRRPVPFPAQALVFLLSIGIAHISPLAAIYSWAAALPLSVLADKVAARRAGPGAGAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBJ0</accession>
    <name>A0A2G1XBJ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28245</name>
        <name evidence="3" type="ORF">CYQ11_07225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48614">
        <property type="protein sequence ID" value="PHQ48614"/>
        <property type="gene ID" value="BLA24_28245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12706">
        <property type="protein sequence ID" value="PPT12706"/>
        <property type="gene ID" value="CYQ11_07225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="194" mass="21172" checksum="3051EAAA8912978E" modified="2018-01-31" version="1">MAMPDMLSSSPFATPTEPRYKTWLIGAGYVLLGLLCMGATATQATKATGEVAHKGTLTVESCTVRHVSGRHGGDKTMCVGTFRPGRGPAVRDETELEGDHIPGEHVRVYREDYEYHLISWRSFWGWLAFFFLSVLAVCRGATTALSGVHARTVDEFTVVRSLMERHPGAPYVAALRWAGAGGLLLCFVFALVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBV6</accession>
    <name>A0A2G1XBV6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C69</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28705</name>
        <name evidence="5" type="ORF">CYQ11_06760</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48690">
        <property type="protein sequence ID" value="PHQ48690"/>
        <property type="gene ID" value="BLA24_28705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12629">
        <property type="protein sequence ID" value="PPT12629"/>
        <property type="gene ID" value="CYQ11_06760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="254"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="509" mass="54438" checksum="7A54106BA38D1C17" modified="2018-01-31" version="1">MPHEIDPSFLALPLRPLADAALARARALGAEHADFRFERVRDASWRLRDARLAGSSDSTDLGYAVRVVHGGTWGFASGVELTMDAAARVASQAVAMAKLSAKVIAAAGSDERVELADEPVHAERTWVSSYETDPFDVPDSDKTGLLAEWSERLLAADGVAHVDASLVTVHENKFYADSAGTTTTQQRVRLHPQLTAVAVDHRTGGFDSMRTLAPPAGRGWEYLTGAGGWDWDAELAEIPSLLAEKMRAPSVEAGTYDLVVDPSNLWLTIHESVGHATELDRALGYEAAYAGTSFATPDLLGTLAYGSQLMNVTGDRTAEHGLATVGYDDEGVAAQSWDLVRDGVLVGYQLDRRIARLTGLGRSNGCAYADSPAHVPVQRMANVSLRPAAGGPSTEELISGVKRGVYVVGDRSWSIDMQRYNFQFTQQRAYAIRDGRLAGQLRDVAYQGITPEFWGSMEAIGGPRTYVLGGAFNCGKAQPGQVAAVSHGCPSALFRGVNILNTANEAGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBZ4</accession>
    <name>A0A2G1XBZ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28885</name>
        <name evidence="4" type="ORF">CYQ11_06580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48721">
        <property type="protein sequence ID" value="PHQ48721"/>
        <property type="gene ID" value="BLA24_28885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12599">
        <property type="protein sequence ID" value="PPT12599"/>
        <property type="gene ID" value="CYQ11_06580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="48"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="143" mass="15549" checksum="6963703553321023" modified="2018-01-31" version="1">MTRSLPASGLQGILSGATPPGLYRLPPAEPPQEVMDLAAEADWRAARLRLDGVHDKAAFLRRCAADLGFPDWFGHNWDALADCLTDLSWWREAGKSRGYLLLAEQWEAFSKAAPADARTAEAVLADAVDFWAEGESPLTVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC91</accession>
    <name>A0A2G1XC91_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27775</name>
        <name evidence="2" type="ORF">CYQ11_17865</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48863">
        <property type="protein sequence ID" value="PHQ48863"/>
        <property type="gene ID" value="BLA24_27775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14490">
        <property type="protein sequence ID" value="PPT14490"/>
        <property type="gene ID" value="CYQ11_17865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="69" mass="7750" checksum="A31AFAAF8BC8EA85" modified="2018-01-31" version="1">MGSRTQAADADARQWEYVTYAPTGETCPACRRKIKPLEPCRRFTVERASAAPVVAYRHAHCGGTREIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCD1</accession>
    <name>A0A2G1XCD1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4031 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27880</name>
        <name evidence="3" type="ORF">CYQ11_17760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48882">
        <property type="protein sequence ID" value="PHQ48882"/>
        <property type="gene ID" value="BLA24_27880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14471">
        <property type="protein sequence ID" value="PPT14471"/>
        <property type="gene ID" value="CYQ11_17760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025109">
        <property type="entry name" value="DUF4031"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13223">
        <property type="entry name" value="DUF4031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4031" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="97" mass="10546" checksum="01C343FF3C71A62B" modified="2018-01-31" version="1">MTLYIDPPHWPGHGRFWSHLISDASLDELHAFAGRLGLPERAFDGDHYDVASASYADAVALGAVEVGSKDVVRLLTAAGLRRRKRGRRNPAAPRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCE7</accession>
    <name>A0A2G1XCE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28020</name>
        <name evidence="3" type="ORF">CYQ11_17620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48906">
        <property type="protein sequence ID" value="PHQ48906"/>
        <property type="gene ID" value="BLA24_28020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14445">
        <property type="protein sequence ID" value="PPT14445"/>
        <property type="gene ID" value="CYQ11_17620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="37617" checksum="24BD1F65FA151645" modified="2018-01-31" version="1">MTTTAFDPFELGGRKLANRIAMAPMTRSRAYGPGATPTEAMADYYAQRASAGLIVTEGVQPSVVGQGYPDTPGLHSAEQVVAWRTVTEAVHRAGGTIYAQLMHTGRVGHPSLLPDGLLPVGPSAVAAKGQVFTHEGPKDFVTPQELTEAAIERTIADFARAARNAVAAGFDGVEVHGANGYLIHQFLAPNANLRTDGWGGSAEGRVRFGVEVATAVADAVGAEKVGFRISPGNPFNDIAETDLEETYGALTEKLAALGLGYLHVMEGPHRDLTHRLRKNWSGAFVLNPFTHPDVTGPESLTLVEDGTADVIAFGALFLANPDLPRRLAAGGPYNTPDPATFYGGDERGYTDYPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCR0</accession>
    <name>A0A2G1XCR0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">BLA24_22845</name>
        <name evidence="13" type="ORF">CYQ11_23230</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48949">
        <property type="protein sequence ID" value="PHQ48949"/>
        <property type="gene ID" value="BLA24_22845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15406">
        <property type="protein sequence ID" value="PPT15406"/>
        <property type="gene ID" value="CYQ11_23230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="31"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="373"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="561" mass="60923" checksum="CE0482ABF306EDA3" modified="2018-01-31" version="1">MSHPHPELGPPPKLPKGGLRVTPLGGLGEIGRNMTVFEYDGRLLIVDCGVLFPEEEQPGVDLILPDFSSIRDRLDDIEGIVLTHGHEDHIGGVPFLLREKPDIPLIGSKLTLALIEAKLQEHRIRPYTLEVVEGHRERIGPFDCEFIAVNHSIPDALAVAIRTPAGMVVHTGDFKMDQLPLDRRLTDLPAFAKLGEEGIDLLLVDSTNAEVPGFVPPERDISGVLRQVFAGAQKRIIVASFASHVHRIQQILDAAHEYGRRVAFVGRSMVRNMGIARDLGYLRVPAGLVVDVKTLDDLPDEEVVLVCTGSQGEPMAALSRMANRDHQIRIVQGDTVILASSLIPGNENAVYRVINGLTRWGANVVHKGNARVHVSGHASAGELLYFYNICKPKNLMPVHGEWRHLRANAELGALTGIPKDHIVIAEDGVVVDLVDGRAKIVGKVQAGYVYVDGLSVGDVTEASLKDRRILGDEGIISVFVVVDSTTGKVVSGPQVQARGSGIDDASFSAVLPKIEEAIAKAAADGVAEPHQLQQLVRRSVGKWVSDSYRRRPMILPVVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD08</accession>
    <name>A0A2G1XD08_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gatB</name>
        <name evidence="13" type="ORF">BLA24_23770</name>
        <name evidence="14" type="ORF">CYQ11_22300</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49102">
        <property type="protein sequence ID" value="PHQ49102"/>
        <property type="gene ID" value="BLA24_23770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15251">
        <property type="protein sequence ID" value="PPT15251"/>
        <property type="gene ID" value="CYQ11_22300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="12">
        <location>
            <begin position="351"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ49102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="502" mass="54243" checksum="0223ACF2821D4307" modified="2018-01-31" version="1">MTVTELVSYEEALATFEPVMGLEVHVELGTKTKMFCGCATELGAEPNSQTCPTCLGLPGSLPVVNGTAVESAVKIGLALHCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAFNGYLDVQLEDGEVFRVEIERAHMEEDTGKSTHVGGATGRIHGARHSLLDYNRAGIPLIEIVTKPITGAGERAPEVAKAYVAELRELIKALGVSEARMEMGQMRCDVNLSLMPKGSEKFGTRSETKNVNSLRSVERAARFEIQRHAAVLSSGGTIVQETRHFHEEDGSTTSGRIKEEAEDYRYFPEPDLVPVAPSREWVEELRGTLPELPRVRRNRLREQWGVSEHDMQSILNAGAVDLIVATIEAGADAASARKWWMGELARRANEAGSDLAALEITPEQVARVCALVAEGSLNDKLARQVIEGVLAGEGGPDQVVEARGLKVVSDEGALGTAVDEAIAANAAIADKIRSGKVAAAGALVGAVMKATRGQADAARVRELILEKLGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD16</accession>
    <name>A0A2G1XD16_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23875</name>
        <name evidence="4" type="ORF">CYQ11_22195</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49118">
        <property type="protein sequence ID" value="PHQ49118"/>
        <property type="gene ID" value="BLA24_23875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15234">
        <property type="protein sequence ID" value="PPT15234"/>
        <property type="gene ID" value="CYQ11_22195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758479" evidence="1">
        <location>
            <begin position="30"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="109"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="590" mass="64134" checksum="84829321B21CE361" modified="2018-01-31" version="1">MTTQRTSRRRLAAGAALVVAALVSTTACGGGGSKDGKGDGKAPGFNAAVNKVANASDKKGGELKFIATQDADSWDPQRGYYGFGWDFARYFTRTLVTPKPAPGEESVAVVPDLATDTGQVSADKKTYTFTLRDGVTWEDGKPVTSRDVKYGIERTWAQDKISGGPLWLMKTLDPDQTYKGPYRDESPDKLGLKAIETPDDKTVVFHLPKPNGDFLQMLAIPAAAPVRADKDTGEKYGLRVFSNGPYKWVSYSPNKGLELTRNDKWKKDSDPVRKALPDKITVKITTNADDMDNKLIAGEYDIDLNATGMGSAGRQNALGSHKANVDNPLTGFIRYAAMPKSVEPFNNEHCRKAVMYGADHTSLQTARGGPQAGGDIGVNMLPPAVKGHDGNYDPFQMKQGKPDEAKAKEELKACGKPEGFSTTIAVRNNKPIEVATAESLQASLKKIGINAQIDQYDGAQYSSIIGAPKNVKAKNYGIIIMGWGADFPSGQGYLQPIADGRFITESGNQNFAEVDEPAINKLFDDAIAEIDPDKAAKIYQEANKKVTEGAWYLPFTYEKNIIWRSSRLTNVYTSDAYNGRYDYASLGVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD72</accession>
    <name>A0A2G1XD72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Co-chaperone YbbN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24205</name>
        <name evidence="5" type="ORF">CYQ11_21870</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49172">
        <property type="protein sequence ID" value="PHQ49172"/>
        <property type="gene ID" value="BLA24_24205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15178">
        <property type="protein sequence ID" value="PPT15178"/>
        <property type="gene ID" value="CYQ11_21870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="314" mass="32650" checksum="CBACF2A2A98D350D" modified="2018-01-31" version="1">MSGVVDLAAVKAAGEAKQKAEQARAEAARQGGVPGAGAGPLVFDVDEAGFELDVLQRSAEVPVVIDFWADWCEPCKQLGPLLERLAQEYAGRFVLAKVDVEANQLLFQQFGVQSIPAVFAVVAGQALPLFQGAAPEAQVRQVLDQLVAVAEQRFGIVGAPAGEGEGVPAAPQAPATPYDSALGAAHDALDAGDLGGAVRAYKNVLSDDPGNPEAKLGLAQAELLQRVQGMDPQQVRKAAADAPGDARAQIAAADLDLAGGHVQDAFGRLIEAVKRTAGEDRDAARVRLLELFEVIGPDDPRVTAARTALSRALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDD2</accession>
    <name>A0A2G1XDD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF742 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Multi-component regulatory system-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24560</name>
        <name evidence="3" type="ORF">CYQ11_21510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49238">
        <property type="protein sequence ID" value="PHQ49238"/>
        <property type="gene ID" value="BLA24_24560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15110">
        <property type="protein sequence ID" value="PPT15110"/>
        <property type="gene ID" value="CYQ11_21510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="139" mass="14531" checksum="E97263F01BB0B86C" modified="2018-01-31" version="1">MTTAPGSLAPAPGPPPDRRTARVRPYSLTGGRSRFGHVLLVETFVAAAGTCAGAGPSEPASGGLASRVMPEVRAIIGLCRRLRSVAEVSALLKMPLGVVRMLLGDLADQGRIRVYGTGHAVGRPDRALLERVLSGLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDG5</accession>
    <name>A0A2G1XDG5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49272">
        <property type="protein sequence ID" value="PHQ49272"/>
        <property type="gene ID" value="BLA24_24755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013961774" evidence="3">
        <location>
            <begin position="38"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="454" mass="46442" checksum="E68A562FBEB2CFAF" modified="2018-01-31" version="1">MSATATRPALPRPLLALVAALIALAGALLYAPAPAHAAGGLDTVAEALRKNPVYVDPRAAGQLPAADADRLARQIKDADKPVFVAVLPAAPEFPRSTVLADLRTKVGISGVYAVHLGDAFNAAADRSVMSRNAVSNLVGSVRRTGGDTNSQLSAFVDAAARTARGHAPGSWSGVEDKGFGTAGLITGGAVVVAGGAGAYALYRRTRRKREERERAELDALRVVVDEDITAFGEELDRLDFSPSEAGATEAMRADYERALDAYEEAKSKMAAAGRPQEVEGVTASLDEGRFALATLAARRTGAPLPERRMPCFFDPRHGPSVQDVEWAPPGGAVRTVPACAADATRLAEGEEPLARQVQTAGGPQPYWNAGPAYAPWAGGYFGGGLLPGLLVGTMLGSMMSGPAYAASPDGGGPEGGDYTGSDYNSDDFGGGGWGDGGGGGDFGGGGGDFGGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDV7</accession>
    <name>A0A2G1XDV7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_25495</name>
        <name evidence="7" type="ORF">CYQ11_20580</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49402">
        <property type="protein sequence ID" value="PHQ49402"/>
        <property type="gene ID" value="BLA24_25495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14948">
        <property type="protein sequence ID" value="PPT14948"/>
        <property type="gene ID" value="CYQ11_20580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="339" mass="36597" checksum="833B2B01D787D426" modified="2018-01-31" version="1">MTSAPPPFLSVRDLSVRFTTEDGVVKAVDGLSFDVEPGRTLGIVGESGSGKSVASLSVLGLHDPRYTEIGGEIVLDGQELTGAPESVLERLRGNKVAMVFQDSLTALSPYYTVGRQIAEPFRKHTGASRRDARLRAIEMLEKVGIPTPALRVDDYPHQFSGGMRQRVMIAMALVCDPLLLIADEPTTALDVTVQAQILDLLKDLQQQTGSSIILITHDLGVVAHTVDDLLVMYAGRAVERGTVREVLGSPRHPYTWGLLGSMPRLASAVDEPLHPIPGTPPSLLAPPPGCPFHPRCGFTGEVAGERCRTQRPELPEGRGAACHLGAERQLRISGERTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDW1</accession>
    <name>A0A2G1XDW1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ORF">BLA24_25620</name>
        <name evidence="5" type="ORF">CYQ11_20450</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49423">
        <property type="protein sequence ID" value="PHQ49423"/>
        <property type="gene ID" value="BLA24_25620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14927">
        <property type="protein sequence ID" value="PPT14927"/>
        <property type="gene ID" value="CYQ11_20450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="635" mass="69684" checksum="D465E2C0842C75D5" modified="2018-01-31" version="1">MPTRHDIRNVAIVAHVDHGKTTIVDAMLKQAGAFAAHQLESVDDRVMDSNDLEREKGITILAKNTAVKYHPKDGGDPITINIIDTPGHADFGGEVERGLSMVDAVVLLVDASEGPLPQTRFVLRKALQQRKPVILCINKTDRPDSRIDEVVNETYDLFLDLDADEDQIEFPIVYACGRDGVASLTKPEDGTVPADSTNLEPFFSTILEHVPAPTYEEDAPLQAHVTNLDADNFLGRIALLRVEQGELRKGQTVAWIKRDGSIQNVRITELMMTEALTRKPAEVAGPGDICAVAGIPEIMIGETLADPENPVALPLITVDEPAISMTIGTNTSPLVGRGGTGKGADAKAAVKDRKVTARQVKDRLDRELIGNVSLRVLDTERPDAWEVQGRGELALAILVEQMRREGFEMTIGKPQVVTKEVDGKTYEPVERMTIDVPEEHMGAVTQLMGVRKGRMDNMSNHGSGWVRMEFVVPSRGLIGFRTEFLTNTRGTGIAHSIHEGHEPWFGTLQTRNNGSLVADRAGAVTAFAMTNLQERGVLFTDPGTEVYEGMIVGENSRSDDMDVNITKEKKLTNMRSSSADSFEAIVPPRKLSLEQSLEFCRDDECVEVTPEAVRIRKVVLDQKERGRTASRAKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEB8</accession>
    <name>A0A2G1XEB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_26500</name>
        <name evidence="8" type="ORF">CYQ11_19135</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49578">
        <property type="protein sequence ID" value="PHQ49578"/>
        <property type="gene ID" value="BLA24_26500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14703">
        <property type="protein sequence ID" value="PPT14703"/>
        <property type="gene ID" value="CYQ11_19135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304744" evidence="4">
        <location>
            <begin position="40"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="78"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="257"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="44667" checksum="AD042A1613DAAB4C" modified="2018-01-31" version="1">MEKRVMTYGKRRKGLVAAAAVLGGVLTLAACGGDGDDDAKDGSGKSQGQVDAAAAKDASKAQIKITPKGGTTDAGISTDAVQVTVSDGELTSVKMTTEKGTPVEGSISSDKKTWKPNSQLERSTKYKVVAEAKDDKGRKATENSSFSTVSPANSFIGAFTPEDGSTVGVGMPVSINFNKPIKDRKAVQSHLEVTSSSGQKVVGHWFGDQRLDFRPQDYWKANSQVTLKMNLDGVEGAPGIKGVQNKTINFKIGHAQVSTVDAKTHKMTVTRDGQVVKTIPISAGSPSNPTYNGKMVISEKFKETRMDGSTVGFSKADGKGEYDIKDVPHAMRLSTSGTFIHGNYWGSGVFGVANTSHGCVGLEDKQGADDPNTPGSWFFSNSILGDVVEVKNSDDKTIAPDNGLNGWNMDWNQWVQGSATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEH0</accession>
    <name>A0A2G1XEH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26800</name>
        <name evidence="2" type="ORF">CYQ11_18835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49628">
        <property type="protein sequence ID" value="PHQ49628"/>
        <property type="gene ID" value="BLA24_26800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14651">
        <property type="protein sequence ID" value="PPT14651"/>
        <property type="gene ID" value="CYQ11_18835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010866">
        <property type="entry name" value="A-2_8-polyST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07388">
        <property type="entry name" value="A-2_8-polyST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="451" mass="48802" checksum="48A60A7EBDA4B323" modified="2018-01-31" version="1">MPARQRTQILLASTLYGAATLAAALDAGLLPAADRRLLVVANTAATPETTAALDEAPGFASLGARFDGLLSWNDAIRPFHPTGWSPRPDDAPLWERHLRLLWDLGTDEVAIVLESLQVNPALALAQIFTDAPLDVYADGLMSYGPTRSKLDPLVGTRVRSLLHLDLVPGLRPLLLSEFGVEPRVVPGEVVTKVLGELADAAAASLPPAPEGAALLLGQYLSALDILTPEEEERLHVRMLRGAVARGHRRVVFKPHPSSPARWSGMLEEEAERLGADLTVLDAPVLAEVLYQRLRPALVVACFSTALLTARTLYGLPVARAGTDLLLERLAPYQNSNRVPVTIVDALLPDLERSGPAAGAGEEDLDGLLAAVGYAMQPQVLPGLRPAAERYLSARLNARTRRYFKRRRLTALALPGAIPSQLAFLPRSPAVRRVVRRARAVRRRLLKRTVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEJ4</accession>
    <name>A0A2G1XEJ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acylneuraminate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_26785</name>
        <name evidence="10" type="ORF">CYQ11_18850</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11344"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60073"/>
            <dbReference type="ChEBI" id="CHEBI:68671"/>
            <dbReference type="EC" id="2.7.7.43"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylneuraminate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CMP-NeuNAc synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KdsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.43" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49625">
        <property type="protein sequence ID" value="PHQ49625"/>
        <property type="gene ID" value="BLA24_26785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14654">
        <property type="protein sequence ID" value="PPT14654"/>
        <property type="gene ID" value="CYQ11_18850"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00628"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008781">
        <property type="term" value="F:N-acylneuraminate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006054">
        <property type="term" value="P:N-acetylneuraminate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="42138" checksum="201AEE83A46EA3AB" modified="2018-01-31" version="1">MSRAVLAVIPARGGSKGVPAKNLAPVGGVPLVARAVRACREARLVTDVVVSTDDPAIAEVARGAGAVVVHRPPALAGDTASSEAAVLHAMDAYESTRARPVAAVLLVQCTSPFLTAQDVDGVASAVVEGGADSALTVAPFHGFVWRGSAPDPAPPAGGRSSGGHGVNHDKATRPRRQDRPQDLLETGAAYAMRADGFRAARHRFFGRTELVRTDAARVLEVDDPHDLARARALAPLLDTAPTALPRHEDVDAVVLDFDGTQTDDRVLIDADGRELVAVHRGDGLGVAALRRAGLAVLILSTETNPVVAARGRKLGVPVIHGSERKDLSLKRWCDEHGIDPQRVLYAGNDVNDLPCLDLVGWPVAVADAHGSVRAAARAVTATPGGRGAVREIAGWLLGEHLAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEW3</accession>
    <name>A0A2G1XEW3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49731">
        <property type="protein sequence ID" value="PHQ49731"/>
        <property type="gene ID" value="BLA24_25340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="208" mass="22408" checksum="CA7D94F7F46C88B8" modified="2018-01-31" version="1">MPEGGPGPRRSVDGYLLASFPWYGLDEAYTGPRWLMQVGAAADGTVEHGSTGHGAEPSLRMGRVEHETGTQRFAVVVTVASRPVRRSADGTGVLEATSVSSAAWLAGSGLLACTWPAQMERALRQDWLDQQTALAWELADRLEESAWSTLSLPVDGVPTDFRYRESEYGWVLAGSPEEGGVHLGAYGRGMSAYGMGFSVIKNITDYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF20</accession>
    <name>A0A2G1XF20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19535</name>
        <name evidence="3" type="ORF">CYQ11_11260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49836">
        <property type="protein sequence ID" value="PHQ49836"/>
        <property type="gene ID" value="BLA24_19535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13388">
        <property type="protein sequence ID" value="PPT13388"/>
        <property type="gene ID" value="CYQ11_11260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="545" mass="55532" checksum="035207DB7FEEBA72" modified="2018-01-31" version="1">MSTPPPGPVSPLVRQRVSGLFTVSDFESKTHQELRAMVEHAKPYEAGALSDRLNVAAAAIKKVGEDLKAHMAEVEWEGEGGDAFRLWGADMANATLRLSGFSEAAGRWMGHAIATLSDVKSSMPEVSASSRATLDSYLHNNPNQLGSVPSPLVTDQTAGLKQQGPSQQQAYDAQKRLDADQAEAAQLMRKLAQSYAWSAHNISVTERPTFPPIDARMMPPSVKDLDDVRVEPGGGPDDAADAASGRPGMAALAAPEGSGSLRHQPADVQFSPSVAPASIQHPGTTQVDGGVSLAQSPTLMQGIGTAQAQPSDAPTGLPLLPPPGIPPVMPVLQAKGLPGGEGATTGRSGSASRLPDRSVASTPGRGMVGGRVGVSSPVFPNEGIIGGRPVPRETGLPQARVPRGTVIGAEPGQGGGQGQARAAMGHGGGYAGGPGVPANQPGAAGQRRVAHEPGWTAGGRPAAGVGKAGSRAFTPGGSGLLRNRGARPNEPQAQGGGGAQGTMTSRSATPAVQPEREGTGRPGYVVEGDETWTQGGLQVVPPVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF45</accession>
    <name>A0A2G1XF45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_19625</name>
        <name evidence="10" type="ORF">CYQ11_11170</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49853">
        <property type="protein sequence ID" value="PHQ49853"/>
        <property type="gene ID" value="BLA24_19625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13371">
        <property type="protein sequence ID" value="PPT13371"/>
        <property type="gene ID" value="CYQ11_11170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="8">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="312"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="474" mass="49183" checksum="FCFA0A286F6CCE3D" modified="2018-01-31" version="1">MTSPSLDGNVPGPGYYPDPSIPGYIRYWSGTAWVPGTSRPAPAEGEPMPAPPASVAASLPALAAPVPPTARQAPQTAGRPAEETGPVFLDEEPEPGQERAARGGAWQADATRQDGFGGENDRRVSWGDASSAAPEHASALPKARDPRLPPAGAPDAAAAPADGGAPASGAPGRGTLQMRPRPQGAAPSGPQTRPAVGEQRAEPAPAAVPAAQAWPGPRTEEPPAEPLRAASLPVRREESAPVPAAAVPSQAQAQAPASAPAPSADRPVGWAQQVHQLAQQQPQPGAGEGVMPWKPPVDDPFLRAARAQGRPAPLGRRLAARLLDTVVLGAVVSAVGVPLWGKSVEHIDAKVEQARQTGRTVTVWLIDGTTGTYLAIVAAVLLVVGVLYEALPTAKWGRTPGKKLFGLRVLDIESHDTPSFGRTLRRWLVYGGLGVLAVGVVNALWCLFDRPWRQCWHDKAAGTFVASADDGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF88</accession>
    <name>A0A2G1XF88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19940</name>
        <name evidence="5" type="ORF">CYQ11_10850</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49906">
        <property type="protein sequence ID" value="PHQ49906"/>
        <property type="gene ID" value="BLA24_19940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13318">
        <property type="protein sequence ID" value="PPT13318"/>
        <property type="gene ID" value="CYQ11_10850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304648" evidence="2">
        <location>
            <begin position="41"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="252" mass="26883" checksum="E9F6D070DABF803C" modified="2018-01-31" version="1">MSARLSTPSRRLAAIGAVVALVVAIVAASLAIGKSGGGSAEHESSAAGTQPSFDPRQSTYDQLEQATSRRKDGDPLAVGKADAPVVLVEYADYQCSFCGRFTRETQPELVRKYVDAGVLRIEFRNFPIFGKDSERAARASWAAGRQGRFWQFHDEAFAKLRKGDALAEDKLADMARTAGVEDVEKFRADMNGDEAAAAVKKDQEEGYSLGVQSTPSFLVGGRPLAGAQPLKEFEAAITQAKAVKDAAGKPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFE7</accession>
    <name>A0A2G1XFE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20315</name>
        <name evidence="4" type="ORF">CYQ11_10470</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49964">
        <property type="protein sequence ID" value="PHQ49964"/>
        <property type="gene ID" value="BLA24_20315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13259">
        <property type="protein sequence ID" value="PPT13259"/>
        <property type="gene ID" value="CYQ11_10470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="2">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="129" mass="13713" checksum="CD4D18276AF3CABD" modified="2018-01-31" version="1">MGAGGSAGGGGRPRPRPQGAPEGHTHTVTTPEDGFNDTIHAPNRLRICAALDAVEEIEFATIRETLGVSPSVLSKHVTVLSDAGYVEQRRGVRDTRQRVWLKLTKTGRAAYHAHLAALRAIVNADLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFE9</accession>
    <name>A0A2G1XFE9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20325</name>
        <name evidence="9" type="ORF">CYQ11_10460</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49966">
        <property type="protein sequence ID" value="PHQ49966"/>
        <property type="gene ID" value="BLA24_20325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13257">
        <property type="protein sequence ID" value="PPT13257"/>
        <property type="gene ID" value="CYQ11_10460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="26104" checksum="082F0C58FC9BA756" modified="2018-01-31" version="1">MALATRTEKPPSLIGSVWRSTVGKKAVMAVTGLIMLAYLVAHMLGNLKVFFGAGEFNHYGHWIRTIGEPFLHREWFLWLARVALGTSVVLHGVAAYQLSRRDIAARPVRYEGARGKKAPRASYATRTMRWGGVILGLFVVWHILDFTTLTVNPNAQEGRPYENLVASFGRWYVSAFYIAAMLALGLHVRHGFWSAAQTLGAASPRRDRALKTLANVLAALLTCGFVAVPLGVLTGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFF4</accession>
    <name>A0A2G1XFF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20310</name>
        <name evidence="3" type="ORF">CYQ11_10475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49963">
        <property type="protein sequence ID" value="PHQ49963"/>
        <property type="gene ID" value="BLA24_20310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13260">
        <property type="protein sequence ID" value="PPT13260"/>
        <property type="gene ID" value="CYQ11_10475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="141" mass="14800" checksum="9580BDCBD5B918A5" modified="2018-01-31" version="1">MPSRESAALSLALATEAQGAVGSLAPGRWYGTSLSAALAGVYFSQLLPDPLDLVGLALMYVLMLTVIVVQLSSSGVRHRMHPSMKRGAILCGVLGLVTFLGAMVLEDWAGMPWIWVPAGLLVAGGVHVLDHKARQKGIPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFH8</accession>
    <name>A0A2G1XFH8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49961">
        <property type="protein sequence ID" value="PHQ49961"/>
        <property type="gene ID" value="BLA24_20300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="246"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="335" mass="35630" checksum="7991D0B7D23882A1" modified="2018-01-31" version="1">MRVLATADRRWTRYAPLTFWVWGGVLMVAGTVWRIVRATGTEPWRTGVVRHLWAGLGGDALWVSVPLALAAVTGLGVAGAVAFYAGHWWGYRLERGQDGGLVVRRGPRGRNAVAIEEARLYGVALREPLLLRAGGGASVRAVAGGLGDRDQNRRRSVVLPPAPRGEAVRVCAEVLGGAVDAQGLRPHPRAALRRRVVWALGWGVLPVTLALGVLGWLLALPVLGYCAVGWTLLAAPVAYGLARDAYRALGHALRGRHLVLRSGTFGRETVSLDRSAVLAWTFTDTPLSRRAGVVTVTAAVPGGEGGYRIRDISAAEAVGFVESAAPGSLREFLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFM3</accession>
    <name>A0A2G1XFM3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20150</name>
        <name evidence="3" type="ORF">CYQ11_10640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49939">
        <property type="protein sequence ID" value="PHQ49939"/>
        <property type="gene ID" value="BLA24_20150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13285">
        <property type="protein sequence ID" value="PPT13285"/>
        <property type="gene ID" value="CYQ11_10640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="402" mass="44895" checksum="BAA5FDFF7835734C" modified="2018-01-31" version="1">MRAGELAAVRGRLEEFVSDVFAPLVRRDQRAKGGLYLRGLLLDGRRKSMQPMAERLGVDHQQLQQFMTSSTWQVEQVRARLAWRAVAVVRPQVWVVDDTGFPKDGRFSPGVARQYSGTLGKVGNCQIGVSVHAASGEASCPLSWRLFLPAAWDGPDAQVRRQACRIPGSERHRAKWQLALDMLDELAGCGLRPAALVADTGYGANADFRHGLDERGLAWVLQVKGEMTAHGQDAVPHQREYGGLGPRPLPRYRTRPVSLREHVLAAGRSRGRTVTWRKGSKAAMSSHFVFLRVRLAGRRPKPAADGTIPLSWLIAQWPEGESEPVKYWISNLPADLPAKDLIRLAKARWRIEHDYRELKTALGLDHFEGRSFAGWHRHVTLVTAAHLFLTEQRTHPKAPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN3</accession>
    <name>A0A2G1XFN3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_20230</name>
        <name evidence="10" type="ORF">CYQ11_10555</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49949">
        <property type="protein sequence ID" value="PHQ49949"/>
        <property type="gene ID" value="BLA24_20230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13273">
        <property type="protein sequence ID" value="PPT13273"/>
        <property type="gene ID" value="CYQ11_10555"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="429" mass="47695" checksum="F5679687B761B3BC" modified="2018-01-31" version="1">MSDNSVVLRYGDGEYTYPVVDSTVGDKGFDIGKLRAQTGLVTLDSGYGNTAAYKSAITYLDGEQGILRYRGYPIEQLAERSSFLETAFLLINGELPTVDELATFKGEITQHTLLHEDVKRFFDGFPRDAHPMAMLSSVVSALSTFYQDSHNPFDEKQRHLSTIRLLAKLPTIAAYAFKKSIGHPIVYPRNDLGYVENFLRMTFSVPAAEFELDPVVVSALDKLLILHADHEQNCSTSTVRLVGSSQANLFASISAGINALWGPLHGGANQAVLEMLESIQASGGDVDAFIRKVKNKEDGVRLMGFGHRVYKSFDPRAKIIKAAAHDVLSALGKSDELLDIALKLEEHALSDDYFVSRNLYPNVDFYTGLIYRAMGFPSEMFTVLFALGRLPGWIAQWHEMIKEPGSRIGRPRQIYTGVVERDFVPVEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFP7</accession>
    <name>A0A2G1XFP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4233 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20865</name>
        <name evidence="3" type="ORF">CYQ11_09915</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50058">
        <property type="protein sequence ID" value="PHQ50058"/>
        <property type="gene ID" value="BLA24_20865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13163">
        <property type="protein sequence ID" value="PPT13163"/>
        <property type="gene ID" value="CYQ11_09915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="114" mass="11908" checksum="9C1BFEA789B45A86" modified="2018-01-31" version="1">MRTLCASTLIGEFFVIGFAGLVAMQTSDLSTGTVWAVSGTAMVLSVLLCGMLTRPGGVQLGWALQIGLIASGLVVPMMFILGVVFAGLWWASVHFGRKVDEAKARFAAAQAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFV7</accession>
    <name>A0A2G1XFV7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_21030</name>
        <name evidence="11" type="ORF">CYQ11_09755</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50081">
        <property type="protein sequence ID" value="PHQ50081"/>
        <property type="gene ID" value="BLA24_21030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13138">
        <property type="protein sequence ID" value="PPT13138"/>
        <property type="gene ID" value="CYQ11_09755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304893" evidence="8">
        <location>
            <begin position="38"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="243"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="658" mass="68403" checksum="010337A468E6E553" modified="2018-01-31" version="1">MGVSLTSRRSRARAGLSLAAALPLVAGALAVGTAAHADPAPHDRQPLVGTKPQWATDRADRGTTSGSDAVGARVYLAGRDAEGLAAYARAVSDPKSPSYGKYLTAEEAKNRFGTTKDQIARVTGWLKSSGLKVTGGNDHYVTVSGDAAAAKKAFGTELHDYVKDGRTYHAPSGTASVPASLGGAVLTVVGLNNAPRLAHHDDTLPGPSAVFRNAGPFSTYYGSNVNDGLPSAYGSHAPYAIKGYTGKQLRAAYGAKNFTGKGVTVAITDAYASPTIAKDIAEYAERNGDKAYRKGQFSQVLPADYTHTKPDECDAAGWYGEETLDIEAVHAVAPEAGIVYVAGASCQDDDLIDSLHKIVDGRLADIVSNSWGDIENNETPDVAAAYDHVFQQGAVEGIGFYFSSGDDGDNTVKHGVKQVDTPANSAWVTSVGGTSLAVGKGDKYLWETGWGTHKAGLSKDGLTWEGFPGTFTGGAGGGTSKAVEQPFYQRGVVPDALAKADGAAKPMRVEPDISAVADSSTGFLVGQTQTFPDGSQKYSEYRIGGTSLAAPVIAGVQALAQQARHGVPIGFANPAIYDRYGTAAYHDVTDHPLGQGRGLGVVRVDYVNGADEKEGLTTSLRSMGGDTSLSATPGYDNVTGVGSPADGYVTSYVPRNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFX4</accession>
    <name>A0A2G1XFX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20745</name>
        <name evidence="2" type="ORF">CYQ11_10035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50039">
        <property type="protein sequence ID" value="PHQ50039"/>
        <property type="gene ID" value="BLA24_20745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13183">
        <property type="protein sequence ID" value="PPT13183"/>
        <property type="gene ID" value="CYQ11_10035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046175">
        <property type="entry name" value="DUF6177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19674">
        <property type="entry name" value="DUF6177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="50927" checksum="74F54465471506D7" modified="2018-01-31" version="1">MTKDVIALTRRMPDAMSVLAGLLAGGPDVRVDTVGDGAVIQLCDAEGRPLVSVETPVMVQVPDEADRLLGPGAEPPGEEPQWWVEARATTGVPEAERLAGAFAARLTMLLGGRVWPPDAPGTQGAAHPVDMSGVTAVPVPAAAQPAVDMLTEQAAVVLQDRPVVPMTSWLSEALRATVESDRSLQVITPPHCRLSLPTRLLLQSVPSRWVVQDERCGYYDGLTGAVLRWQENAFVPDRDDRGETPVADSFAEFQPTDERQLVLSFRTLHRPDADLVLGGAVEAAWQALTGALPAGWGTAEPAGLVWSRRQLTDLAYRRAPEPTWTVVVGDADRPAIATLRVIRTPEGVEEDVTLTVGYGAGEKPPLEALPELAAELVTGHGLKTMLCQLRAARRDLTAPARFERPPMPYAFVLGAAEVREAGRELASRTPLARTPVQLGPDAAPGFYYPLGDGESEECWETFGGLVRHLRGAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG83</accession>
    <name>A0A2G1XG83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21845</name>
        <name evidence="2" type="ORF">CYQ11_08940</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50215">
        <property type="protein sequence ID" value="PHQ50215"/>
        <property type="gene ID" value="BLA24_21845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13001">
        <property type="protein sequence ID" value="PPT13001"/>
        <property type="gene ID" value="CYQ11_08940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="169" mass="19233" checksum="9547924B59C07924" modified="2018-01-31" version="1">MTSDQRVGPPSFGSERDMLRAFLDYHRATLAMKCEGLTDEELRRQSMPPSTLSLLGLVRHMAEVERAWFRRVFEDNDAPMVWSDEIDFQAAYDAGASTRHEAFAAWEAEVETSRRIEREARSLDQAGHQPRWGEDVSLRMVMVHVLLEYGRHNGHADFLREGVDGAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG93</accession>
    <name>A0A2G1XG93_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22125</name>
        <name evidence="4" type="ORF">CYQ11_08660</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50254">
        <property type="protein sequence ID" value="PHQ50254"/>
        <property type="gene ID" value="BLA24_22125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12960">
        <property type="protein sequence ID" value="PPT12960"/>
        <property type="gene ID" value="CYQ11_08660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="27204" checksum="35F5CC9C59C06339" modified="2018-01-31" version="1">MSVLSPHSPPRHARWWQRPGVVIALLVVLPPVGIVLAWLSDWPRRKKTIAIVLSALWLALFVATPSKAEHEGKGKAAAPKPAGRASASPAPSPTPSETPSPTPPPTPTPTADPQMPDVVNMPYGKASDALKKLVDGGTEAYSAYTDVELVNDHDDWTVCFQSPSAGTPLAPAHAAPKIHVAPPGTPCPKSKNTELHPKPTTEPGPDPDRKPGTGGASGGSAGGGGVGVVHPGAFCSPQGATGVTTKGTPMTCAPSTGGRNRWRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGA6</accession>
    <name>A0A2G1XGA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22190</name>
        <name evidence="4" type="ORF">CYQ11_08595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50266">
        <property type="protein sequence ID" value="PHQ50266"/>
        <property type="gene ID" value="BLA24_22190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12948">
        <property type="protein sequence ID" value="PPT12948"/>
        <property type="gene ID" value="CYQ11_08595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="21655" checksum="401938240A03F024" modified="2018-01-31" version="1">MATPRTPDSTRRSERSRRAIFDAALELVGEVGYDKLTIEGIAARAGVGKQTIYRWWPSKAAVLLDAFTADAGDYEAGLPDTGDLAADLRFVLRASVDEFNDPKFQAPYRALAAAGANDAELSADFVARLMEPGIKVYTDRLRAARDQGQVAEDADLRVAAEMLLGPFSQRWLMRTGPLTYEFTDTLVDLVVRAVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGB0</accession>
    <name>A0A2G1XGB0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22010</name>
        <name evidence="4" type="ORF">CYQ11_08775</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50241">
        <property type="protein sequence ID" value="PHQ50241"/>
        <property type="gene ID" value="BLA24_22010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12974">
        <property type="protein sequence ID" value="PPT12974"/>
        <property type="gene ID" value="CYQ11_08775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="150"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="28610" checksum="F708DA2598A83E03" modified="2018-01-31" version="1">MSLLSHERYCGEVIAETELLCTALRDADVSTPVPTCPDWTLAQLVLHLGGAHRAVEAVVRTRATEFAVPDVSQEAGGPAPADAAALAAWLTEGAATLVAALREAGPDARVWTFGGEQPAAFWFRRMAHETVIHRADAFAAVGSPFAVAPEVAADCLDEWLDILAFLHRLGRLPELSDVTGPDRTLHLHATDAAPELDAEWVIDGTQEHIAWRRAHEKAAVAVRGPLADLLCLVYRRLPLKDADRIEVVGDRELLEAWLERAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGN8</accession>
    <name>A0A2G1XGN8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_19735</name>
        <name evidence="11" type="ORF">CYQ11_11055</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50361">
        <property type="protein sequence ID" value="PHQ50361"/>
        <property type="gene ID" value="BLA24_19735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16490">
        <property type="protein sequence ID" value="PPT16490"/>
        <property type="gene ID" value="CYQ11_11055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="147"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="209"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="426" mass="44218" checksum="41ABCADEC7B9625D" modified="2018-01-31" version="1">MGIRGRIALAISFVTALAVVVLGVAVHHISGLERDSQAMAYQDELLSSALQVYQRDGSLALGAQLDDATLPSPLARVVVKGESGMYISGGDDPRVWAATPVGDGKVLSVSASYPARDPLQTALDKALVVAGAATVALMAVVAWFVAQSLSRRLRLSAAAARRIAAGETPDADALNGGGRDEVAELGRSVHHMATSLAARVSAERQFTADVAHELRTPVAGLVASAELLPHPRAVEMVQERAQTLRALVEDLLEVSRLDAGVESAQLDAVELPSLVRGIVKRARGQRGVEDVTVAVVGEGRIVATDARRVERILVNILANAAKHGRPPIEVTVEGTRIVVRDHGDGFPPGLVDQGPRRFRTAAPERGTGHGLGLTIAVGQAAVLGARLEFGAAEGGGARAVLDLPEAEDVPEEGAPVCRGGARVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGZ9</accession>
    <name>A0A2G1XGZ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16905</name>
        <name evidence="3" type="ORF">CYQ11_16375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50507">
        <property type="protein sequence ID" value="PHQ50507"/>
        <property type="gene ID" value="BLA24_16905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14237">
        <property type="protein sequence ID" value="PPT14237"/>
        <property type="gene ID" value="CYQ11_16375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="154" mass="15660" checksum="DF7756F93D063570" modified="2018-01-31" version="1">MSAVEDKLAELGLTLPDVVPPLAAYQPAVRSGAYVHTAGQLPMVKGSIPVTGKVGAEVSAEQAKELAAVCALNGLAAVKSVIGDLDKIVRVVKVVGFVASAPDFTGQPGVINGTSELLGEVLGEKGVHARSAVGVAVLPLDAPVEVEFLVEVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH52</accession>
    <name>A0A2G1XH52_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17290</name>
        <name evidence="3" type="ORF">CYQ11_15985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50568">
        <property type="protein sequence ID" value="PHQ50568"/>
        <property type="gene ID" value="BLA24_17290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14178">
        <property type="protein sequence ID" value="PPT14178"/>
        <property type="gene ID" value="CYQ11_15985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="97" mass="11292" checksum="573E92A2F7CAA740" modified="2018-01-31" version="1">MIRHLVLFKLNEGVERDDPRVVAGVRAFEELEKAIPELRSWECAWNISDRPIAYDYAINCSVEDTDALQRYLDHPAHQAGVGQWREFATWVIADYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK9</accession>
    <name>A0A2G1XHK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetate-CoA oxygenase subunit PaaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paaJ</name>
        <name evidence="2" type="ORF">BLA24_18175</name>
        <name evidence="3" type="ORF">CYQ11_15100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50713">
        <property type="protein sequence ID" value="PHQ50713"/>
        <property type="gene ID" value="BLA24_18175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14034">
        <property type="protein sequence ID" value="PPT14034"/>
        <property type="gene ID" value="CYQ11_15100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011883">
        <property type="entry name" value="PA_CoA_Oase4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02159">
        <property type="entry name" value="PA_CoA_Oxy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="17844" checksum="8E18AB20027E1CD0" modified="2018-01-31" version="1">MVSAPTPLEEELRALAGAVPDPELPVLSLAELGVLRGLRLTGPGRVEVELTPTYTGCPAVEAMSADIERVLREHGQREVTVRTVLSPAWSTDDITAEGRRKLAEFGIAPPRPTGPDGPVMVDLAIRCPHCGSTDTTLLSRFSSTACKALRRCEACREPFDHFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHN4</accession>
    <name>A0A2G1XHN4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18350</name>
        <name evidence="4" type="ORF">CYQ11_14930</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50742">
        <property type="protein sequence ID" value="PHQ50742"/>
        <property type="gene ID" value="BLA24_18350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14001">
        <property type="protein sequence ID" value="PPT14001"/>
        <property type="gene ID" value="CYQ11_14930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="172"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="276" mass="30761" checksum="4B4062E0E4C9ED8F" modified="2018-01-31" version="1">MTVHPSLQPAIDAWTHSVEAVSDLVRPLAESDWNRATECPGWSVRDVVSHIIGVECEMLGEPRPIHTLPRDLRHVTDEFSRYIEVQVDVRRCHTAPEMTSELEYTIIRRCRQLRNETRPPQATVRWPLGTANEQTLERTLALRAFDVWTHEQDLRRALGVPGNLDSPAAVISRDFLLRALPKLVAEDAGARPGSTVVFDVHGPLEFLRTVRVGPQGKATIDGSVSLGPSVTFALDWETYARLACGRVRPEAVADRVKIDGDRELAGAVLREFAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHN5</accession>
    <name>A0A2G1XHN5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsW</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">FtsW/RodA/SpoVE family cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_18100</name>
        <name evidence="9" type="ORF">CYQ11_15175</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50701">
        <property type="protein sequence ID" value="PHQ50701"/>
        <property type="gene ID" value="BLA24_18100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14045">
        <property type="protein sequence ID" value="PPT14045"/>
        <property type="gene ID" value="CYQ11_15175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="50645" checksum="B3474659E6166E2C" modified="2018-01-31" version="1">MSAISPMSNNTTTISTAGPPSRRNTELALLAFAVIIPCFAYANVGLAIDDELPSGLLGYGIGLGLLAGVGHLVVRKFAKYADPLLLPLATLLNGLGLILIWRLDQSPRLMQLAKNQGFKFVPYAPNQLLYSALGIALFVAVVIFLKDHRVLQRYTYISMVVALALLIAPMFFPPKFGARIWITIPGLGGLQPGEFAKIVLAVFFAGYLMVKRDALALASRRFMGLYLPRGRDLGPILAVWAFSILILVFETDLGTSLLFFGMFVVMLYVATERTSWIVFGLLMSAAGAVGVASFEHHVQERVDAWLNPFAVFETHKGTEQIGQALMSFGSGGVFGTGWGQGNSDLIGFAANSDFILGTVGEELGLAGVMAVLLVYGLIVERGVRTALAARDPFGKLLSVGLSGAFAIQVFVVAGGVMGLIPLTGMTMPFMAYGGSSVLANWALIAILMKISDAARRPAPAPAPSPDAEMTQVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHP0</accession>
    <name>A0A2G1XHP0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18320</name>
        <name evidence="3" type="ORF">CYQ11_14955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50737">
        <property type="protein sequence ID" value="PHQ50737"/>
        <property type="gene ID" value="BLA24_18320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14005">
        <property type="protein sequence ID" value="PPT14005"/>
        <property type="gene ID" value="CYQ11_14955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="164" mass="17471" checksum="274B8671FB524EA5" modified="2018-01-31" version="1">MGEKDAHGQHELPKPVFLPAGPGQEGFAPAPGSTLSKFIPNLYDPTSRSPLITPYPGLNGPVKPDLKIEPKVLTGAAGKAGEIRTAFAQPAASLDEPTRAAAKGLDGMASKTALETMHHYWEEQAGTVAAWLDNIAQSLRLAANDYHRTNLGVKDYFKSSGQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHU2</accession>
    <name>A0A2G1XHU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain protein CspD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18770</name>
        <name evidence="5" type="ORF">CYQ11_14510</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50812">
        <property type="protein sequence ID" value="PHQ50812"/>
        <property type="gene ID" value="BLA24_18770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13930">
        <property type="protein sequence ID" value="PPT13930"/>
        <property type="gene ID" value="CYQ11_14510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7281" checksum="3BB99C0DECE14DE1" modified="2018-01-31" version="1">MATGTVKWFNSEKGFGFIQQDGGGADVFAHYSNIATQGYRELQQGQKVSFEISQGQKGPQAENILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI48</accession>
    <name>A0A2G1XI48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_18840</name>
        <name evidence="10" type="ORF">CYQ11_14440</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50918">
        <property type="protein sequence ID" value="PHQ50918"/>
        <property type="gene ID" value="BLA24_18840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16557">
        <property type="protein sequence ID" value="PPT16557"/>
        <property type="gene ID" value="CYQ11_14440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="272" mass="28540" checksum="B8F0CDB1C7931FB4" modified="2018-01-31" version="1">MSTTATAAEAAGTGVPAAPTTLAGRALTLGRAEFTLLGRNKTALYITLFLPALMVYAMRSGTKNVDLDGSGLSLKDVTMTGAFGYVLIFAVYYNLMSVYTARREQLVLKRLRTGEAGDVEILAGTALPSAVIALAQCLLLVTGGVAWLDMRVPARPELLVAGLLLGVVMLTALAAASTALARTAETAQFAAMPLAMVSMLGSGLFVPLDILPDMLATACELLPLTPVVELMRDGWLGGASVGGTLGHLGAALVWSALGVFAVRRWFRWEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI75</accession>
    <name>A0A2G1XI75_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17805</name>
        <name evidence="3" type="ORF">CYQ11_15470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50891">
        <property type="protein sequence ID" value="PHQ50891"/>
        <property type="gene ID" value="BLA24_17805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16581">
        <property type="protein sequence ID" value="PPT16581"/>
        <property type="gene ID" value="CYQ11_15470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="68" mass="7633" checksum="7122562D5CDBAB34" modified="2018-01-31" version="1">MSGPSLWRTPRILCTTRGKPLWTNTQSPGAHPSDLRFYRPPAVEEKNFPGRGEMATNGADKITHNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG2</accession>
    <name>A0A2G1XIG2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="10" type="ORF">BLA24_14635</name>
        <name evidence="11" type="ORF">CYQ11_13435</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51017">
        <property type="protein sequence ID" value="PHQ51017"/>
        <property type="gene ID" value="BLA24_14635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13760">
        <property type="protein sequence ID" value="PPT13760"/>
        <property type="gene ID" value="CYQ11_13435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="109"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="299" mass="32425" checksum="A664D359E2C59B6D" modified="2018-01-31" version="1">MSDPNLNDAAEPVEATEADVDAPAPADSEEVGEDTETQILQNADGGDELDAEEAAAGEPAEEAALRVEGEDAEDAEEAEGTEEEAAEPAEEEAPADPVDALREELRGLPGEWYVIHTYAGYENRVKTNLEQRAVSLNVEDYIFQAEVPQEEVVQIKNGDRRTVRQNKLPGYVLVRMDLTNESWGVVRNTPGVTGFVGNAYDPYPLTLDEIVKMLAPEAEAKAAKEAAEAEGRPAPSRKVEVQVLDFEVGDSVTVTDGPFATLQATINEINADSKKVKGLVEIFGRETPVELSFDQIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIL9</accession>
    <name>A0A2G1XIL9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="8" type="ORF">BLA24_14820</name>
        <name evidence="9" type="ORF">CYQ11_13250</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51050">
        <property type="protein sequence ID" value="PHQ51050"/>
        <property type="gene ID" value="BLA24_14820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13727">
        <property type="protein sequence ID" value="PPT13727"/>
        <property type="gene ID" value="CYQ11_13250"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="SSF57774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="23771" checksum="1C508BBB35E4A38F" modified="2018-01-31" version="1">MRIVLVGPPGAGKGTQAAYLAKNLAIPHISTGDLFRANISQGTPLGQKAQEYMRAGQLVPDEVTIGMAKDRMQQADAAHGFLLDGFPRNLAQAEALDEILKADGLGLDAVLDLEVPEDEVVKRIAGRRMCRKDSSHIFHVIYNPPAAEGVCDVCGGELYQREDDSEETVRKRLEVYHSETEPIIDYYKAQGLVVTISALGKVAEVTQRAMGALPSREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ70</accession>
    <name>A0A2G1XJ70_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formimidoylglutamate deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16155</name>
        <name evidence="3" type="ORF">CYQ11_11920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="PPT13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51277">
        <property type="protein sequence ID" value="PHQ51277"/>
        <property type="gene ID" value="BLA24_16155"/>
    </dbReference>
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        <property type="protein sequence ID" value="PPT13498"/>
        <property type="gene ID" value="CYQ11_11920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="52"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="445" mass="46490" checksum="0D170F5E50B924DB" modified="2018-01-31" version="1">MQVTTYWAEHAWLDPVVESGVAVDVADGRITAVRTAVTAPPPGAVSLRGLTLPGLANAHSHAFHRALRARTQEGSGTFWTWRDVMYGVAGALTPDSYFALARATYAEMALAGITCVGEFHYLHHAPGGTPYANPNAMGEALIAAAAEAGIRITLLDTAYLSAGFGEPPNRHQQRFSDGTADAWAERAAALTPADHARIGAAVHSVRAVPADQLATVADWAKDREAPLHVHLSEQTAENDACLAAHGCTPTRLLADHGVLGPRTSAVHATHLTDDDIRLLGDAGSTICMCPTTERDLADGIGPAARLQRAGSPLSLGSDSHAVIDLLEEARALELDERLRTRTRGHWTAAALLRAATADGHASLGWAEAGRIEAGALADFTTVALDSVRTAGPPARLGAETAVFAATGQDVRHTVVAGRHVVRDGAHQLVPDVPGALADSIAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJB8</accession>
    <name>A0A2G1XJB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C biogenesis protein ResC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14095</name>
        <name evidence="4" type="ORF">CYQ11_13980</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51327">
        <property type="protein sequence ID" value="PHQ51327"/>
        <property type="gene ID" value="BLA24_14095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16548">
        <property type="protein sequence ID" value="PPT16548"/>
        <property type="gene ID" value="CYQ11_13980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="34"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="261" mass="26956" checksum="56FF1B79B9723888" modified="2018-01-31" version="1">MTGSPAAAHVLAAATDTNQTVLSGALLLALPVAVLGGLISFFSPCVLPLVPGYLSYVTGVSGADLAEARRGRMVAGSSLFVAGFSAVFVSAGAFFGYFGKTLQDHKETISMVLGGLTIVLGLAFMGALGLFGQREFRFHTRPAIGLAGAPVLGVLFGVGWTPCIGPTLAAVQSLSFNQASAGRGALLTVAYCLGLGLPFVLTAVAFRRALGAFGWVKRHYVWVMRAGGAMLVVVGLLLVTGVWDSMVGELQTWSQNFTPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD9</accession>
    <name>A0A2G1XJD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14985</name>
        <name evidence="4" type="ORF">CYQ11_13085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51346">
        <property type="protein sequence ID" value="PHQ51346"/>
        <property type="gene ID" value="BLA24_14985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16531">
        <property type="protein sequence ID" value="PPT16531"/>
        <property type="gene ID" value="CYQ11_13085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304897" evidence="2">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="194" mass="19409" checksum="2F97EA1270211C40" modified="2018-01-31" version="1">MARSSSGAIVAALTAAALAGVGFLAVQAEAAPDRPAAAHASAGKDKGQDSGGQGAGDAAGQDQGKGPEAVPQGSGAGMRVVYALAQKRVWLVGADEKASHTFEVSPSTVSPPPGTYKVTSRTLNVTGSDGTPIEHVVIFHRDAAGIVFGFSAAVDGRPPNPTPGKKTGGIRENPADGLAMWQFAVSNTKVVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJI2</accession>
    <name>A0A2G1XJI2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13820</name>
        <name evidence="3" type="ORF">CYQ11_01515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51408">
        <property type="protein sequence ID" value="PHQ51408"/>
        <property type="gene ID" value="BLA24_13820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11749">
        <property type="protein sequence ID" value="PPT11749"/>
        <property type="gene ID" value="CYQ11_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="42441" checksum="E1889A9CCCCA6155" modified="2018-01-31" version="1">MNRQDGPERPYDVVLFGATGYVGELTAEYLLAHAPQGCRLALAGRSRDKLEGLRERLAALDPERAAGLAVVAADASDPVAMRALAESTHVVASTVGPYIWYGEALVAACAEAGTDYTDLTGEPEFVDLMFVRYGARARATGARIVHACGFDSLPHDLGVYFTVQRLPEGVPLTVDGFVRARGMVSGGTLTSALTIVGRRSQALAAARERRRYEERPVGRRVRAPMGAPRFSKETGTWALPLPTLDPMVVRRSAAALERYGPDFRYRHYASVKTLPVALAAPAGVGVLAAAAQVPSVRSWLAGRYAPGRGPSARQRARGWFRLRYVGAGGGRRVFTEVTGGDPGYGETAKMLAESSLCLALDELPTTSGQVTPATAMGDALIERLETAGVPFRVRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK14</accession>
    <name>A0A2G1XK14_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore-associated protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13275</name>
        <name evidence="3" type="ORF">CYQ11_00995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51479">
        <property type="protein sequence ID" value="PHQ51479"/>
        <property type="gene ID" value="BLA24_13275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11661">
        <property type="protein sequence ID" value="PPT11661"/>
        <property type="gene ID" value="CYQ11_00995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758361" evidence="1">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="162" mass="17048" checksum="9B18F00EFB8FB5D1" modified="2018-01-31" version="1">MRLATSSEDTVKCAVSTRVAGAALLAAATTVTALAAGTGTSVAAPARAAAYNRECGTGYTQVNQIPIPGRGTVFLTYNAATGKNCVVTKRNSSTGSPLWMGSWLQRNTELKSKQEQYGSFTSYSGPVYLDAKGKCVDWGGEIDGYVVARYKTNCATLAQTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKD1</accession>
    <name>A0A2G1XKD1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_12945</name>
        <name evidence="12" type="ORF">CYQ11_17305</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51599">
        <property type="protein sequence ID" value="PHQ51599"/>
        <property type="gene ID" value="BLA24_12945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14392">
        <property type="protein sequence ID" value="PPT14392"/>
        <property type="gene ID" value="CYQ11_17305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305596" description="Histidine kinase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="245"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="474" mass="49968" checksum="94CD9DFB631D43F2" modified="2018-01-31" version="1">MITRFRRLPLRSRLALLTAAAVAVAVALAAGACWFVTKEQLAHQRDTTLTSQRVDERSVQELIRSCGTNPSGLPPAPGSYTVQVVTAGGLVCTTPGKAAIRVTDADLAVARGRADEVLHDGTAVDGKEMRVATYASDQLARTAISIAQPLSETEKPLNALALVLVLTAGVGVLGAAMAGLGIARAGLRPVDQLTDAVEHIARTEDLAVRIPVEGEDEIARLSRSFNSMTAALASSRDRQAQLIADAGHELRTPLTSLRTNIDLLARSEETGRAIPPEDRKELLASVKAQMTELAELIGDLQELSRPDGPEGGAPLQVVPLHEAVGRAVARARLRAAGSGLVVDDRTDPWYVRAEPAALERAVVNLLDNAVKFSPPGGVIEVRLVNGELTVRDHGPGIPDHELPHVFDRFWRSPSARSLPGSGLGLSIVARTVQQAGGVVTLRPAEGGEGTVATVRLPGAATEPPPLTGDEPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKI1</accession>
    <name>A0A2G1XKI1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GlxA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11650</name>
        <name evidence="3" type="ORF">CYQ11_02890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51737">
        <property type="protein sequence ID" value="PHQ51737"/>
        <property type="gene ID" value="BLA24_11650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11985">
        <property type="protein sequence ID" value="PPT11985"/>
        <property type="gene ID" value="CYQ11_02890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="224"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="326" mass="34189" checksum="978CCEEC6AC72ABC" modified="2018-01-31" version="1">MATVSGKVETRDVLIVVYDGVQLLDVAGPLDVFDRAGREADAGYRVRLASVGGWDVATSAGAALGVSADLARVRKPPDTLVVAGGHGYAAAAGDPDLVRHVRRLSAGARRTGSVCTGAFVLAEAGLLDGRRATTHWAYCTELAAGYPAVSVEPDAIFVRDGTVVTSAGVTAGIDLTLSLLEDDCGPEVARAVAKFLVVFMKRPGGQSQFGSRARNETLRGGALRDLVDAIDGDPSGDLSVPALAARLGMSRRHFSRLFTQEVGVSPGAYVERARVAVARSLLEGSADGVDAIAARCGFNTVETMRRAFVRETGVSPAAYRDRFRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKN2</accession>
    <name>A0A2G1XKN2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11445</name>
        <name evidence="3" type="ORF">CYQ11_02680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51699">
        <property type="protein sequence ID" value="PHQ51699"/>
        <property type="gene ID" value="BLA24_11445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11948">
        <property type="protein sequence ID" value="PPT11948"/>
        <property type="gene ID" value="CYQ11_02680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304916" evidence="1">
        <location>
            <begin position="34"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="451" mass="50370" checksum="1949F13D003D9429" modified="2018-01-31" version="1">MSPTGPRRRRSALFLTLLLSLGTFTAAAGPAQAGPRADDPAEALARAASPLRTTEPLGDLGDLRPLGRMVGDASVVGMGEATHSSHEFFTDKHRVFRYLVEEKGFTAFALEAPWSTGLRLNDYVLHGKGDARQIMKEEFQRDYTFWNTREYLDLIEWMRAYNTRHDRKVQFVGDDIGYTGPQVFDEITRYVAAHHRALLPRFTELYRAQRPAPGTSVGDAMRAYLQRPLAERRDMAERAHRALDLLSRQQPGPDRAAFDLAVQHARVVAQTADEYAYDLEDAQDVARAMRHRDESMAANVAWWHERTGSKVLLSAHNAHVAYESEDPGHYPRMQGAFLREKLGKGYLAVRQSFGQGSFNATTDPDESKIEVCTVGPAEPGGNEHTLDRVSREDYLLDLRTAPAGARSWLATARPSRDIGTAYPEPLHPVALGSSYDVLIHLHRVTAARRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKS8</accession>
    <name>A0A2G1XKS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12185</name>
        <name evidence="5" type="ORF">CYQ11_03425</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51830">
        <property type="protein sequence ID" value="PHQ51830"/>
        <property type="gene ID" value="BLA24_12185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12077">
        <property type="protein sequence ID" value="PPT12077"/>
        <property type="gene ID" value="CYQ11_03425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="53"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="31329" checksum="35661DC0C7D02279" modified="2018-01-31" version="1">MQTKWTEVRAGHIRAIRPRSRSESRAEQVIQQSTTSPWFLRFPQDPACRTRLVCFPHAGGAASYYVPYARALSPEVDVLAVQYPGRQNRYSEAHIEDIGTLADEIAAALEPWLDLPTALFGHSMGAVLAFEVTRRLERRGDFDAARLFVSGCPAPSRRREETFRKLDGDLDDNGVIAELRALSGTNAAVFENEELLRLTLPTIRSDYTAVRNYRAEPGAAVRAPVTVLAGDSDHRTTPDELQAWQTHTTATCDVHTFTGGHFFINDHAGEIVGLITDRLLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKT1</accession>
    <name>A0A2G1XKT1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11420</name>
        <name evidence="3" type="ORF">CYQ11_02655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51848">
        <property type="protein sequence ID" value="PHQ51848"/>
        <property type="gene ID" value="BLA24_11420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16312">
        <property type="protein sequence ID" value="PPT16312"/>
        <property type="gene ID" value="CYQ11_02655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="14782" checksum="4770288C1E4EBAF9" modified="2018-01-31" version="1">MRRALRQLAGRRQPMTAAPEVLAELQGLRVRVPHLTGAMVASTDGLVIAHLVTGMEPDGVAALTAAALGVGSRLAAAVGHGGFRELLVCGDQGYVATYAAGSACVLTLLASSDANVGRLNLEARRAGARIAALAESSLERQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKY3</accession>
    <name>A0A2G1XKY3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_01860</name>
        <name evidence="11" type="ORF">BLA24_01885</name>
        <name evidence="9" type="ORF">BLA24_03375</name>
        <name evidence="8" type="ORF">BLA24_11080</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000132">
        <property type="protein sequence ID" value="PHQ51895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000034">
        <property type="protein sequence ID" value="PHQ53348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000034">
        <property type="protein sequence ID" value="PHQ53351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51895">
        <property type="protein sequence ID" value="PHQ51895"/>
        <property type="gene ID" value="BLA24_11080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53124">
        <property type="protein sequence ID" value="PHQ53124"/>
        <property type="gene ID" value="BLA24_03375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53348">
        <property type="protein sequence ID" value="PHQ53348"/>
        <property type="gene ID" value="BLA24_01860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53351">
        <property type="protein sequence ID" value="PHQ53351"/>
        <property type="gene ID" value="BLA24_01885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="187" mass="21341" checksum="AFA5C46BC1048F6A" modified="2018-01-31" version="1">MEAASMASSGKVLDFEEYVRNRQDALLRSARRLVPDPIDAQDLLQTALVRTYGRWDGIADKSLADAYLRRVMINTRTEWWRARKLDEVPTEQLPDASVEDGTEQHADRALLMDILGVLAPKQRSVVVLRHWEQMSTEETAEALGMSTGTVKSTLHRALARLRQELESRNLDFHALERRERGQERCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKZ5</accession>
    <name>A0A2G1XKZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10685</name>
        <name evidence="3" type="ORF">CYQ11_00870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51913">
        <property type="protein sequence ID" value="PHQ51913"/>
        <property type="gene ID" value="BLA24_10685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11642">
        <property type="protein sequence ID" value="PPT11642"/>
        <property type="gene ID" value="CYQ11_00870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23963" checksum="DB0E823A6172E981" modified="2018-01-31" version="1">MKNATGHAGQRAGAERDVKAAIAAERRELADLLEGLRADEWNTPSLCEGWRVREVVAHMSMGFRLSLPATLGELVKARGNLHRMTDRVARGDAAAHSVGELSGFLRDNAHHPWTPPVGGVVAALGHDVVHGLDVTVALGLDRRVPEDRLRILLDDIKPSGLRFFGVDLRGVRLCAEDMDWSYGSGAPVYGAAQDLLLLAFGRRLAHGRLRGEPSDRFTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL00</accession>
    <name>A0A2G1XL00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_10720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51918">
        <property type="protein sequence ID" value="PHQ51918"/>
        <property type="gene ID" value="BLA24_10720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="98" mass="10594" checksum="E1CF8F1FBE16FDCF" modified="2018-01-31" version="1">MRIQALSDLPLSAVRRGRPGSSRGCALRVSGAGASPRTGFEDHGAVGECIADAPICMLERLGIRRDLLLPGRLVPAEPTVRRLLARDPRRPLALLRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL19</accession>
    <name>A0A2G1XL19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_10740</name>
        <name evidence="9" type="ORF">CYQ11_00810</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51922">
        <property type="protein sequence ID" value="PHQ51922"/>
        <property type="gene ID" value="BLA24_10740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11633">
        <property type="protein sequence ID" value="PPT11633"/>
        <property type="gene ID" value="CYQ11_00810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="10393" checksum="37FF5BBBA4C38E38" modified="2018-01-31" version="1">MGILAWIIIGLLAGAIAKALMPGKDPGGMLVTMLIGIVGGLLGGFLGKIMFGVESINGFFHLSTWIAAIVGSVIILALYRVFARRNHRHHGHGRHSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM6</accession>
    <name>A0A2G1XLM6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1876 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09515</name>
        <name evidence="2" type="ORF">CYQ11_28125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52145">
        <property type="protein sequence ID" value="PHQ52145"/>
        <property type="gene ID" value="BLA24_09515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16226">
        <property type="protein sequence ID" value="PPT16226"/>
        <property type="gene ID" value="CYQ11_28125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="89" mass="10106" checksum="9F8086916F25C17D" modified="2018-01-31" version="1">MQTIVGWHVEVEFEEVDKRTRAACMLRLQDGTELRARGHATRHPDDPEQQRVGEELAAARALNELSRELLKKAGHDIEEATHVEAHPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM06</accession>
    <name>A0A2G1XM06_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_09650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52169">
        <property type="protein sequence ID" value="PHQ52169"/>
        <property type="gene ID" value="BLA24_09650"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="364"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2551"/>
            <end position="2626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3520"/>
            <end position="3562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="3546"/>
            <end position="3562"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1506"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="3562" mass="374229" checksum="23B8E4CCF802BDC8" modified="2018-01-31" version="1">MLLAGHPAYVLYTSGSTGRPKGVVVSHGAFANLSLSHAKFGVGPGCRVAQFASVGFDMFCEELLLGLLSGAALVVVPSDRRVGAELAGFLRDEGVTHATLPTAVVASIPPGEVLPEGFVLDIGGEACPPELVERCTADGRVMFNSYGPTETTVNATSWPCHMGAVEPGVVPIGRPIANNRVYVLDGSLHPVPPGVVGELYVTGSGLARGYLGRPGLTGERFVACPFEPGERMYRTGDRVRWTVDGQLVFAGRTDDQVKIRGFRIEPGEVETVLGFHPHVGQLAVVVREDVPGDARLVGYVVPSGAGINDLGESVRDFAAERLPSYMVPAAFVVLDALPLTVNGKLDRKALPAPDFAAAVGGGRAPADAREELLCQGFAEVLGLPVVGVDDDFFSLGGHSLLAVSLVEWLRARGVSVSVRALFATPTPAGLAAVAGPGQVVVPPNRIPIGTSEIKPEMLPLVELTEAELARVVAAVPGGAANVADVYPLAPLQEGIFFHHLMGNGDGSDVYASPTVVQFDSRERLDAFLAAFQRVVERHDIYRTAIVWEGLREPVQVVARHVDLPVEEVVLDPEADAVTQLLSAGGSRMELGRAPLMTVCVAAEAGTSGRWLALLRVHHLVQDHTALDVLLGELRAFLSGTDDELPVPLPFREFVAQARSGGAREEHARYFAELLGDVEETTAPFGLLDVHGDGTGIAQGRLPVEDALAGRLREVARSLGVSPATVFHMAWARVLATVSGRDDVVFGTVLFGRMNAGAGADRVPGLFINTLPVRVRVKGQSVGEALAGMRGQLADLMVHEHAPLTVAQSASGLPGGTPLFTSLFNYRHTRPTPGAGDQVDGIRTVFSQDRTNYPLTVAVDDEGSGFVLVVDASTPVDPGLVCALTHTAVANLVTALEEAPDTCFATVGVLDPAERRRLVEGGDAPAAPGPEATVSAVATAPAVTIPELFAAQAARTPDAIAVTHGSAEVSYAQLDAQANRLARLLISRGVGPESFVAVVMDRSAELMVALLAVLKAGGAYVPLDPAYPAERIAFTIGDASPALVLAQAATAASVASAADAGAVPVVVVDAPETLGELAECDDTEPADVERRGALLPHHPMYVIYTSGSTGRPKGVVIPHANVVSLFRATADWFEYRAEDVWTWFHSVAFDFSVWELWGALLHGGRLVVVPFETSRSPVDFLDLLARERVTVLNQTPSAFYQLTQAEAATPGAGRDELALRRIVFGGEALDPARLAGWYDRPPGDTPLLVNMYGITETTVHVTHVPLGSDAPARSTTGSMIGRALAGLRVYVLDQALEPVPPGVAGEMYVSGTQLARGYAGRPGLTGERFVACPFEPGERMYRTGDRAWWTADGQLVFAGRADDQVQIRGFRIEPAEVRAVLAEHEGVEHAAVVVREDVPGDARLVGYVVPAGAGARGLGESVRGFAAERLPSYMVPSAVVVLDALPLTVNGKLDRKALPAPDFAAAVGGGRAPADAREELLCQGFAEVLGLPVVGVDDDFFSLGGHSLLAVSLVGWLRARGVSVSMRALFATPTPAGLAAVAGPGQVVVPPNRIPEGAGEVTPEMLPLVDLTEAEIAAVTASVPGGATNVADVYPLAPLQEGMFFHHLMAERGGGDVYVLPLALAFDTREHLDAFTFGLQRVVDRHDIYRTAIVWEGLREPVQVVARHVDLPVTEIVLDEEGPEPVDQLLHAAGSWMDLRCAPLLRMTVAAEPGADGRWLALLRIHHMVQDHTTLEVLLGELRAFLTGNEEALPEPLPFREFVAQARLGVSREEHERYFAALLGDVTETTAPYGLLDVHGDGTADVQAHLPVEDALAGRLREVARSLGVSPATVFHLAWARVLATVSGRDDVVFGTVLFGRMNGGAGADRVPGLFINTLPVRVRVGEQGVGEALAGMRGQLADLMVHEHAPLSLAQAASGVTGGRPLFTSLINYRYDRATSAADSGLEGVRALFSREHTNYPLDVAVDDDGTGFVITVDAVPSVDSAHVCAMLHAALGNLITSLERDPGARFDAVGVLGGVERRRVLVEWNESAVAGPAVTVPDLFAGQVARTPGAVAVVCGGREVSYGELDERANRLARLLIGRGVGPESVVGVVLGRSPELLVAILAVLKAGGAYLSVDAGLPVERVGFVLGDAAPVVVLADTATVSAVAACDAAVPVVVMEAPEMAGELAGLSGAPVDDGDRCGALLAGHPAYVLYTSGSTGRPKGVVVSHGAFANLSLSHEKFGVGPGCRVAQFASVGFDMFCEELLLGLLSGAALVVVPSDRRVGAELAGFLRDEGVTHATLPTAVVASIPPGEVLPEGFVLDIGGEACPPELVERCTADGRVMFNSYGPTETTVNATSWSCRPDLVDGDAVPIGRPIANNRVYVLDGSLHPVPPGVVGELYVTGSGLARGYLGRPGLTGERFVACPFEPGERMYRTGDRVRWTVDGQLVFAGRADDQVKIRGFRIEPGEAEIVLGAHAGVAQAAVAVREDTPGDKRLVAYLVPSDHGTEDLVDSVRRHAGEGLPSYMVPAAFVVLDALPLTVNGKLDRKALPAPDYAGAMGSTGRAPGSVREELLCHAFAEVLGLPVVGVDDDFFALGGHSLSAVRLVSRMRSVLGAEIPLRTLFEHPTPAALAALLEQAAPGRVALSAHEQRPERVPLSFAQRRLWFLAQLEGPSATYNIPLALRMRGELDRDALTAALQDVVGRHEALRTVFPIADGEPYQRVLSADEAAFALSVRDVAAEDLADEVTRAITYAFDFSAEVPVRAWLFAVAPDEHVLVLVLHHIAGDGWSMGPLARDVSVAYAARCAGGEPGWSALPVQYADYALWQRELLGDEGDPDSVISRQVAYWREALAGAPEELELPVDRPRPAESSHRGYVARVDVPADVHQALLRRARAEGVTLFMAVQAALSALLSRLGAGDDIPIGVAVAGRTDQALDDLVGFFVNTLVMRTDLSGDPTLTEVLGRVRETSLAALAHQELPFEKLVENLAPARSLVRHPLFQVMLTLRNSSPTSGDGSVAEALPGLRVDVLAADVSAAKFDLDVNLDEVFDAEGAPAGLRGGLTVSADLFDAGAAERFAGWFVRVLATLADAPGTRLSAVEVLSSAERGVLLGGWGGGGVVSVPDVSVPELFGVWVGRAPGAVAVVCGDVSLTYGELGGRVSRLARCLVAAGVGSESRVAVLMERSVDVVVVLLAVLRAGGVYVPLDVAWPVGRMEEVVGDAGACVLVVDAGLVGHGLVGWARAGGVGVVSADAEMDAECDAGVLLPVVRAGQAAYVMYTSGSTGRPKGVVAAHGDVVRLALDRCWGASGSMRVLFHAPHAFDASSYELWVPLLSGGTVVVAPPVAVDAGVLRGLISAHGVSHVHVTAGLLRVLAERDPGCFVGVREVLTGGDVVPAGAVRRVLECCAGVVVRHLYGPTEVTLCATQWVVSDAAVVGDVVPMGRGLDNTRVLVLDGSLCLVPPGVVGELYVVGAGVARGYVGRPGLTAERFVACPFVSGERMYRTGDRVRWTADGQLVFAGRVDDQVKIRGFRVEPGEIESGHRGPPAWPGGGHGPRGHPRRQAPGRLRGARRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM18</accession>
    <name>A0A2G1XM18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08845</name>
        <name evidence="2" type="ORF">CYQ11_04100</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52256">
        <property type="protein sequence ID" value="PHQ52256"/>
        <property type="gene ID" value="BLA24_08845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12188">
        <property type="protein sequence ID" value="PPT12188"/>
        <property type="gene ID" value="CYQ11_04100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="26115" checksum="20DB5CBB69BBB02A" modified="2018-01-31" version="1">MTTEEREPTGKVALVTGASRGIGYGIAEALVARGDRVVITGRNEDALKEAVEKLGAGWAVGVPGKAHDEAHQAQAVERAMEAFGRVDYLVNNAGTNPVFGPIADVDLAVARKVFETNVVSALGFAQQTWKAWQKDNGGAIVNIASIAGVTASPFVGVYGVSKAAMANLTLQLAHEFAPVARVNTIAPAVVKTKFAAALYEGREEEAAASYPLGRLGVPEDIGGAAAFLLSDAAGWITGQTLVVDGGLFLNAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM42</accession>
    <name>A0A2G1XM42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2797 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08600</name>
        <name evidence="3" type="ORF">CYQ11_03855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52280">
        <property type="protein sequence ID" value="PHQ52280"/>
        <property type="gene ID" value="BLA24_08600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16335">
        <property type="protein sequence ID" value="PPT16335"/>
        <property type="gene ID" value="CYQ11_03855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021246">
        <property type="entry name" value="DUF2797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10977">
        <property type="entry name" value="DUF2797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="296" mass="31939" checksum="17C24CDA87FFC06E" modified="2018-01-31" version="1">MNDGREQWWCAGLRWSGEDPALLWRHPGHGERLSPLPPGRPLAFSTGDRRRCTGVRRNGRHTPCPDHAEVPATAVSSQCPQCARLDRSYSVASDTAVDDPRPYDVYLAWFAPGLIKVGITAAEREGARLLEQAALSSALLGRGPLMAARRAEAVLGAALAVPDRFPYAAKRAARHPLPARERRTSELAALHERARALAPESLAVRDFAPVHHDRVFHLDRLRPGYGVVRLAPGRTVAGRVAAVAGPDVYLDTPDGQLLLVDARQLAGWSLSAAAPDAGTTAEVHTPESAEPPEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM43</accession>
    <name>A0A2G1XM43_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07700</name>
        <name evidence="3" type="ORF">CYQ11_00130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52334">
        <property type="protein sequence ID" value="PHQ52334"/>
        <property type="gene ID" value="BLA24_07700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11538">
        <property type="protein sequence ID" value="PPT11538"/>
        <property type="gene ID" value="CYQ11_00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304856" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="121" mass="12668" checksum="1EB61EE857EA27E0" modified="2018-01-31" version="1">MRRLRTAGLALLGATLAASVTASPAQASPGETRTVCADSMTPDGWVDVNWGTSASCRVMSGSNIKMIKQLDGLPVGTQVNACASAQPPKGWTKIQTYYSGGCVVFVNSSFTPNAWLLQKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM48</accession>
    <name>A0A2G1XM48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08820</name>
        <name evidence="3" type="ORF">CYQ11_04080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52251">
        <property type="protein sequence ID" value="PHQ52251"/>
        <property type="gene ID" value="BLA24_08820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12184">
        <property type="protein sequence ID" value="PPT12184"/>
        <property type="gene ID" value="CYQ11_04080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="34470" checksum="87F7E24C968B4BB4" modified="2018-01-31" version="1">MSGRTPTDQGGPVKVGCIGLGDIAQKAYLPVLAAQPGVEPHLQTRTPATLHRVADTHRVPDAHRHTDLDSLLAAGIDAAFVHAPTVTHPEIVTRLIEAGIPTYVDKPLAYDLGESERLVRLAQDRRVSLMVGFNRRYAPGYAQCLDHPRDLILMQKNRVGLPEDPRSLVFDDFIHVVDTLRFLAPGPVDHVDVRARVRDGLAHHVVLHLSGDGFTAIGTMNRMSGSTEEILDVSGRDTKRQVLNLAEVVDHKGQPTVRRRGDWVPVARQRGIEQITQTFLDAVRAGRTLDAEDALRTHELCERVVGRISEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMD6</accession>
    <name>A0A2G1XMD6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2267 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07845</name>
        <name evidence="2" type="ORF">CYQ11_00280</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52415">
        <property type="protein sequence ID" value="PHQ52415"/>
        <property type="gene ID" value="BLA24_07845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16259">
        <property type="protein sequence ID" value="PPT16259"/>
        <property type="gene ID" value="CYQ11_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="131" mass="14160" checksum="3C922A6E808CA232" modified="2018-01-31" version="1">MTLRREAFLDHVKERGEYGTVKEAERAARVVLALLGAHLVGEVRSQLAARLPEGFALILLNPLQSAEPLSPERFIRATAAWIEGATEQTATWDVSAVLSAVADTAGDDLLGQILLQLPAGYDLLFGRPQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMG2</accession>
    <name>A0A2G1XMG2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07675</name>
        <name evidence="4" type="ORF">CYQ11_00105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52329">
        <property type="protein sequence ID" value="PHQ52329"/>
        <property type="gene ID" value="BLA24_07675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11533">
        <property type="protein sequence ID" value="PPT11533"/>
        <property type="gene ID" value="CYQ11_00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="40204" checksum="3CFC0BA8D50C6DEF" modified="2018-01-31" version="1">MRRRIAVVGSGPAGLTFARVLHRHSHPVTVLERDAAPDARPPGGTLDLHEGLGQLALDKAGLLAEFQALSRPEGQAMRILDTAGTVLRDWRPRPGDRANPEIDRRQLRDLLLGPLDVQWGRGVTQVVPGTRDGVLVEFADGRQETFDLVVGADGAWSRVRPAVSSVTPHYTGVAFVETSLDDVDTRHPGLARLIGDGSLAVYGVNRALVAQRNSGGHVKVYAQFRAPLDWHTNLDLADVEAVRSSLLALFDGWAAPVLDLLRHGTMFVHRPLYVLPVSHTWTHAFGVTLLGDAAHLMPPLGAGANLAMFEGAELAEAIATGPEDLDEAVRAFEEQMWARAGRWAKITTAGLERLVSPDPAEALALFDQVHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNA1</accession>
    <name>A0A2G1XNA1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06035</name>
        <name evidence="3" type="ORF">CYQ11_03560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52661">
        <property type="protein sequence ID" value="PHQ52661"/>
        <property type="gene ID" value="BLA24_06035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12095">
        <property type="protein sequence ID" value="PPT12095"/>
        <property type="gene ID" value="CYQ11_03560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="8030" checksum="17BCDD143BC8F8DF" modified="2018-01-31" version="1">MKKKTIDLLQFATLVIGAWFGIIPVIFKIVGNHTKGAFLPLYLPDPASMIVAGVVSVVSLVMIFALDKTKRNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNB5</accession>
    <name>A0A2G1XNB5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05435</name>
        <name evidence="2" type="ORF">CYQ11_01895</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52718">
        <property type="protein sequence ID" value="PHQ52718"/>
        <property type="gene ID" value="BLA24_05435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11812">
        <property type="protein sequence ID" value="PPT11812"/>
        <property type="gene ID" value="CYQ11_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="136" mass="15180" checksum="863F390BE326C7EB" modified="2018-01-31" version="1">MSEYESSRTMPALPEHVFDQVNSVERLSGWLPEDLHVRAEELPAVTVHEDRTGEDEPGLFRAQADQMRVEWGTRESGNYAGWLQVAGMDGGASEVTIHLSFFDEGDDPGEEIVNTALAHSLERLEEQVRLRVDEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNI7</accession>
    <name>A0A2G1XNI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05800</name>
        <name evidence="4" type="ORF">CYQ11_02275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52776">
        <property type="protein sequence ID" value="PHQ52776"/>
        <property type="gene ID" value="BLA24_05800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11878">
        <property type="protein sequence ID" value="PPT11878"/>
        <property type="gene ID" value="CYQ11_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758888" evidence="2">
        <location>
            <begin position="30"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="33108" checksum="334DFFD477BEF755" modified="2018-01-31" version="1">MVNQRQAALAAGAITLMMLTAACGGSPSAKERQGDDVKPAANSSEAAKGYGYGAGAGAAGGYGAGDAQGAAAPGEPGGKLAVRETPDLGQFVTDGKGFTLYRFDKDSAKPPASRCDGDCAKAWPPVPAGEVSVSVGIDAGALGEVARSDGSKQLTLGGWPVYRYAKDTAPGDAKGQGVGGTWNALAPDGKKAGGKGEKKEQPAPEGVSVSDNAKLGKILVDGQGRTLYRFNKDSAWPMKFACTDACLETWKPAKPVDKASVKGVAEKLVTTVTRPDGTKQLAIDCWPVYWFTGDGKPGDVNGQGKQGLWFAVDDKGAKVTAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNL3</accession>
    <name>A0A2G1XNL3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_05305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000071">
        <property type="protein sequence ID" value="PHQ52834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52834">
        <property type="protein sequence ID" value="PHQ52834"/>
        <property type="gene ID" value="BLA24_05305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="125" mass="13209" checksum="6F439C3BF18E2F80" modified="2018-01-31" version="1" fragment="single">FLELGFDSLTSVELRTQLNRATALRLPATVVFDYPTPAALAAHLAATLFAAADDTAGEPGEEEIRRALAAVPISRFREAGLLPALLRLADTAEAGPDAPTDDETSELDSMDIENLIEIALDGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN8</accession>
    <name>A0A2G1XNN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05950</name>
        <name evidence="3" type="ORF">CYQ11_02425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52801">
        <property type="protein sequence ID" value="PHQ52801"/>
        <property type="gene ID" value="BLA24_05950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11903">
        <property type="protein sequence ID" value="PPT11903"/>
        <property type="gene ID" value="CYQ11_02425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="156" mass="17422" checksum="F7FC022FE53DA784" modified="2018-01-31" version="1">MQKITPFLWYDGQAEEAVEHYTSVFDDSRIVDVQRYGEEGPGEPGTVMTVTFELAGQRFVALNGGPEFTFTEAVSFSVDCATQDEVDELWARLGEDGQEGPCGWLKDKFGLSWQITPRVLTDLLSDPDPVRSGRVMKAMMGMTKIDIQGLLDAYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNU0</accession>
    <name>A0A2G1XNU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CsbD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_04800</name>
        <name evidence="5" type="ORF">CYQ11_28730</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52886">
        <property type="protein sequence ID" value="PHQ52886"/>
        <property type="gene ID" value="BLA24_04800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11455">
        <property type="protein sequence ID" value="PPT11455"/>
        <property type="gene ID" value="CYQ11_28730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="62" mass="6667" checksum="AA75CDC043E574FC" modified="2018-01-31" version="1">MKELKMSASEKAKAKGEQTVGKVKKEAGRMVGNESKAAEGRAEEAKGNLRGAKEKVKDAFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP97</accession>
    <name>A0A2G1XP97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000061">
        <property type="protein sequence ID" value="PHQ53046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53046">
        <property type="protein sequence ID" value="PHQ53046"/>
        <property type="gene ID" value="BLA24_04080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="118" mass="13060" checksum="FA9165B462FE12BF" modified="2018-01-31" version="1" fragment="single">MPTGVTDRLIVRGAREHNLKNVSLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPI3</accession>
    <name>A0A2G1XPI3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02080</name>
        <name evidence="3" type="ORF">CYQ11_04445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53155">
        <property type="protein sequence ID" value="PHQ53155"/>
        <property type="gene ID" value="BLA24_02080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12245">
        <property type="protein sequence ID" value="PPT12245"/>
        <property type="gene ID" value="CYQ11_04445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="112" mass="12518" checksum="E0B298C463A4474F" modified="2018-01-31" version="1">MSKRQKGRRHRRVNRTPRPVGSSRPRTPRPESRPEARSEPRQVPDLGRHEARTWDGLREAGDGGASVDDLCATVGYQARTIVKHVTGLAGHGLAELRGDRWYATAEGRLVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPL0</accession>
    <name>A0A2G1XPL0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_02220</name>
        <name evidence="9" type="ORF">CYQ11_04580</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53177">
        <property type="protein sequence ID" value="PHQ53177"/>
        <property type="gene ID" value="BLA24_02220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12269">
        <property type="protein sequence ID" value="PPT12269"/>
        <property type="gene ID" value="CYQ11_04580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="357" mass="36384" checksum="3FB1CE1D93D0F9CA" modified="2018-01-31" version="1">MAALATAKRGDDREAGVRTVRAGWACAALGAALLVALVASVCLGSTSVEPGEVWSAVLRGVTGREPAPGTQDLIVWRLRVPRALLAALVGAGLGLVGTATQALVRNPLGDPYLLGVSSGASLGAVAAIVLGASAGGALGLGLSAAAFAGALLSFALVWTFARRAGDFSPLRLVLAGVGIGQFLSGFTHYLVLQAGDEQQTHGALFWMMGSLGGAQWDTLTLPAVAVLLGLAALLARSRALNAMLMGDETAASLGVDVGRLRRELFVVTSLLTGVLVAVSGAIGFVGLMVPHACRMVVGGDHRRLLPVAALFGALLLVVVDLLARTALPDQELPVGVVTALIGAPTLLYLLDRRLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPQ3</accession>
    <name>A0A2G1XPQ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53129">
        <property type="protein sequence ID" value="PHQ53129"/>
        <property type="gene ID" value="BLA24_03405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="46" mass="4668" checksum="FDF1EF0F1DA6B0DC" modified="2018-01-31" version="1" fragment="single">TGQEIGLSGSTGNSSGPHLHFEIRTTPNYGTAVDPVAFMGAHGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPW9</accession>
    <name>A0A2G1XPW9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_02935</name>
        <name evidence="13" type="ORF">CYQ11_05230</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53284">
        <property type="protein sequence ID" value="PHQ53284"/>
        <property type="gene ID" value="BLA24_02935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12379">
        <property type="protein sequence ID" value="PPT12379"/>
        <property type="gene ID" value="CYQ11_05230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ53284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23142" checksum="ACA83D507CCC129D" modified="2018-01-31" version="1">MLNKYARAFFTRVLTPFAALLIRLGVSPDAVTLIGTGGVVAGALVFYPQGEFFWGTVVITLFVFSDLVDGNMARQLGRSSRWGAFLDSTLDRVADSAIFGGLALWYAGRGDSLIVCAVAIFCLASGQVVSYTKARGESIGLPVNVNGLVERAERLVISLVACGLSGLHAFGVPHIDKLLPIALWIVAVGSLVTLIQRVVTVRRESAEADAAVTVGGGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ95</accession>
    <name>A0A2G1XQ95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_01145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000013">
        <property type="protein sequence ID" value="PHQ53417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53417">
        <property type="protein sequence ID" value="PHQ53417"/>
        <property type="gene ID" value="BLA24_01145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="98" mass="10297" checksum="E90B052D4DA3B4BC" modified="2018-01-31" version="1">MGSGTPDLNAPSESLEDFKRRVDRLLEKLDGSAASHTKIADQKVKGGAYGNFAEAQALASAYDTVHAQLEVLSRALGDRLSAMGIAVSAGQGVPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQA8</accession>
    <name>A0A2G1XQA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00370</name>
        <name evidence="3" type="ORF">CYQ11_07380</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53425">
        <property type="protein sequence ID" value="PHQ53425"/>
        <property type="gene ID" value="BLA24_00370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12729">
        <property type="protein sequence ID" value="PPT12729"/>
        <property type="gene ID" value="CYQ11_07380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19328" checksum="EA2FB219C314EDB2" modified="2018-01-31" version="1">MPRTPTRCYAFISHRLIRAALGDSPPRDVRWITPGPGLRCAEIGSGGGFYTTALARHLGPGSLLVALDPAAHDPRAQHGAGPGARTVHVAGDGCALPFASAALDALLYSYSLEEMPEHTALAEAERVLRPGGQLVLFLWRPLVGRHRTTALTHLARGGAFELRRADRGLQNLRLAYRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQI8</accession>
    <name>A0A2G1XQI8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_00695</name>
        <name evidence="8" type="ORF">CYQ11_07705</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53483">
        <property type="protein sequence ID" value="PHQ53483"/>
        <property type="gene ID" value="BLA24_00695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12788">
        <property type="protein sequence ID" value="PPT12788"/>
        <property type="gene ID" value="CYQ11_07705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="362"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="436" mass="42248" checksum="38FD54A6059457B5" modified="2018-01-31" version="1">MAEKSATKAVPARSAVGSARPAKAGAGGKTAPAKKSTAPAAAKSAAGGKKAATKKSVPTGGAAGKATPAKKATTAKTAAGGKAAPVKKAAAAAKAAAAKKTTAAKKAAPGGKAAPAKKATTTKTAAGGKATPAKKAAKAAEPAPAKKTGTAARTATAAPAKAAAKKSASAGKGAPGRKTAPVKKSAPAKKATAADKAAAAGKTATVARAARQGEDATGAAAGTGKAAAKAAPARGTAPKAGPDGTAPPRKPARRAGAASDDRAASAASAPAGTAVPAKETGARTVAAKKSTDEAQAAKKVPGARTGAVLAVRPGEEPWSPAEVAGARSELQTDAARLRAEIAASDAAISGLMRDSGDGAGDDQADTGTKNITREHELALAANAREMLMQTERALERLDAGTYGLCENCGKPIGKARMQAFPRATLCVECKQRQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQL9</accession>
    <name>A0A2G1XQL9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_01000</name>
        <name evidence="7" type="ORF">CYQ11_08010</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53538">
        <property type="protein sequence ID" value="PHQ53538"/>
        <property type="gene ID" value="BLA24_01000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12843">
        <property type="protein sequence ID" value="PPT12843"/>
        <property type="gene ID" value="CYQ11_08010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304946" description="NlpC/P60 domain-containing protein" evidence="4">
        <location>
            <begin position="36"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="239"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="131"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="37562" checksum="8CD371937D1C0D6B" modified="2018-01-31" version="1">MASHRRPKQPSRTRVTVLTATAAAAVALSAQAAHADSPSKADAKTKVDKLYEEAEQATEKFNGAKEKQEQLEKEVGDLQDKVARGQEELNKLRNGLGAIATAQYRSGSVDPTLQLLLSSDPDSYLEKASTLNQLTAKQAEALKRIADKQRTLRQERQQATGKLADLESTRKALGEKKQEIQGKLSDAQDVLNTLSAKERAEITGADKDSGGKSGGSGSGSGADTGSGSSASRPKVPAGSGRAAAALAAADTKAGKAPYVWGATGPNSFDCSGLTSWAYAQAGVNISRTSQEQANDGTRIYDQSQLKPGDLVLFYGDLHHVGLYAGNGMTLHAPKPGTNVRYEAMSNMPFQFGVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQQ3</accession>
    <name>A0A2G1XQQ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_01010</name>
        <name evidence="2" type="ORF">CYQ11_08020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53540">
        <property type="protein sequence ID" value="PHQ53540"/>
        <property type="gene ID" value="BLA24_01010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12845">
        <property type="protein sequence ID" value="PPT12845"/>
        <property type="gene ID" value="CYQ11_08020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="8884" checksum="64E963EC2B80F0D7" modified="2018-01-31" version="1">MGIPQPSAGTRWRCTLCGNLTRFDVTRRTTAVEFVHLDLSGEPTVEEREVLSETIESVRCRWCNAVDQIELVDRPGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQR3</accession>
    <name>A0A2G1XQR3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">coxB</name>
        <name evidence="18" type="ORF">BLA24_01075</name>
        <name evidence="19" type="ORF">CYQ11_08085</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53553">
        <property type="protein sequence ID" value="PHQ53553"/>
        <property type="gene ID" value="BLA24_01075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12858">
        <property type="protein sequence ID" value="PPT12858"/>
        <property type="gene ID" value="CYQ11_08085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="17">
        <location>
            <begin position="135"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PHQ53553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PPT12858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="35792" checksum="833E9F0A7A616CC6" modified="2018-01-31" version="1">MSPNGSDRSSRRPVRRKLLQALAAGAVLATATGCTSKDFPRLGMPTPVTEEAPRILSLWQGSWAAALVVGVLVWGLIIWSVLFHRRSRSKVEVPVQTRYNMPLEALYTVVPIIIVSVLFYFTARDENKLLTNPDKPQHVVNVVGFQWSWAFNYMENVDGNAATPAQPLRQNKELDAIPDRFLQKAPAGAEGVYEVGVPGDRNPQNGNPGPTLWLPKGETVEFILTSRDVVHSFWVVPFLMKQDVFPGHTNSFTVTPSKEGTYMGKCAELCGQDHSRMLFNVKVVSPERYRAHLKELAAKGQTGYQPAGIAQTDHAKNAETKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9A6</accession>
    <name>A0A2G1X9A6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30335</name>
        <name evidence="2" type="ORF">CYQ11_23430</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47813">
        <property type="protein sequence ID" value="PHQ47813"/>
        <property type="gene ID" value="BLA24_30335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15438">
        <property type="protein sequence ID" value="PPT15438"/>
        <property type="gene ID" value="CYQ11_23430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="81" mass="8543" checksum="E8C20705329424A9" modified="2018-01-31" version="1">MGLLNDLKAKLGPLKGKVGDLAHQHEDKIGHGLEKAAQVVDAKTKGKYSSQIRTGTGKAREALGRLAEKDHKGGGTDSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9H1</accession>
    <name>A0A2G1X9H1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="7">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cpfC</name>
        <name evidence="9" type="ORF">BLA24_30640</name>
        <name evidence="10" type="ORF">CYQ11_23735</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47868">
        <property type="protein sequence ID" value="PHQ47868"/>
        <property type="gene ID" value="BLA24_30640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15493">
        <property type="protein sequence ID" value="PPT15493"/>
        <property type="gene ID" value="CYQ11_23735"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ47868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="375" mass="40148" checksum="5B16EB0B006DD7FB" modified="2018-01-31" version="1">MSDQPAHAPYDALLLLSFGGPEGPDDVVPFLENVTRGRGIPRERLQEVGQHYFLFGGVSPINGQNRELLAALRAEFAAHGTDLPVYWGNRNWAPYLTDTLRQLVADGHRRVLTLATSAYASYSGCRQYRENLADALAALEAEGLPLPRVDKLRHYFNHPGFVRPMVDATLAALAELPEEARQGAHLAFTTHSIPTAAADASGPAGDHGDGGAYVAEHLDVARLIADAVRAETGVERPWRLVYQSRSGAPHVPWLEPDVCDHLEAVRAEGASGVVMVPIGFVSDHMEVKYDLDTEATAKAAELGLPVARAATVGADPRFAAAVRELVLERAASERGERPERCALGALGPSHDRCPVGCCPARSPRPAAAGADSPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9I4</accession>
    <name>A0A2G1X9I4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_30785</name>
        <name evidence="8" type="ORF">CYQ11_23880</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47894">
        <property type="protein sequence ID" value="PHQ47894"/>
        <property type="gene ID" value="BLA24_30785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15519">
        <property type="protein sequence ID" value="PPT15519"/>
        <property type="gene ID" value="CYQ11_23880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ47894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="683" mass="73848" checksum="A64FD9A2E00046FA" modified="2018-01-31" version="1">MSKLTDLPKRILIGRALHSNKLGETLLPKRIALPVFASDPLSSVAYAPGEVLLVLSAAGVSAYHFSPWIAVAVVVLMFTVVASYRQNVHAYPSGGGDYEVANVNLGPKAGLTVASALLVDYVLTVAVSIASGIENLGSAIPFVVEHKTACAIAVIVLLTLMNLRGVRESGKLFAIPTYVFVGGVFLMIAWGAYRGLIAGDTMKAPTADYTISAEHQGLAGFALVFLLLRAFSSGCAALTGVEAISNGVPAFRKPKSKNAATTLALMGGLAVTMFCGIIALAMVTKVRMAEEPATHLLNNGTPVGEEYTQNPVISQVAEAVFGGGSFLFILLAAATALVLFLAANTAYNGFPLLGSILAQDRYLPRQLHTRGDRLAFSNGIVLLAGAAAVLTYIYGADSTKLIQLYIVGVFVSFTLSQTGMVRHWNRLLAGETDPGKRRQMIRSRAINTFGAFLTGLVLVVVLLTKFTHGAWVALLGMVIFYATMTAIRKHYDRVADEIAAEEAPGDETVRPSRVHSIVLVSKVHKPTLRALAYAKLMRSDTLEALSISVDPVETKALREEWHRRNIDVPLKILDSPYREITRPVIDYVKGLRKESPRDAVSVFIPEYVVGHWYEHLLHNQSALRLKGRLLFTPGVMVTSVPWQLDSSEVARKRARKRAEWNAPGSVRRGPVTQPKKEKAATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9K0</accession>
    <name>A0A2G1X9K0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30840</name>
        <name evidence="2" type="ORF">CYQ11_23940</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47902">
        <property type="protein sequence ID" value="PHQ47902"/>
        <property type="gene ID" value="BLA24_30840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15527">
        <property type="protein sequence ID" value="PPT15527"/>
        <property type="gene ID" value="CYQ11_23940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="94" mass="9697" checksum="7122E231F6920CB8" modified="2018-01-31" version="1">MADDGTDFPPGNGPTSGISISLTAGTLQAIRERVGKRGVSAYLERAAQRQIERDNLDELIADFDKTHGPADPEAVAAKRAKLTSGTSSDAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9V8</accession>
    <name>A0A2G1X9V8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Indole-3-glycerol phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31635</name>
        <name evidence="2" type="ORF">CYQ11_24690</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48008">
        <property type="protein sequence ID" value="PHQ48008"/>
        <property type="gene ID" value="BLA24_31635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15634">
        <property type="protein sequence ID" value="PPT15634"/>
        <property type="gene ID" value="CYQ11_24690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="166" mass="18448" checksum="B5C74AD07FD988B1" modified="2018-01-31" version="1">MFTSVLMIEQPLSAADVEFVTTLHDDSMSFVVLMRPRGNEDRLLRAIDDVALGELEQAVHEADEPEGEEALRPAALALEHSLRRLRDAGCEAVGQIIDGHPLDLLRSVVEQTHADEVIVLTAPHLVEEFFHRDWASQARHKVGVPVLKLYAHNDEDVNQAETADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9X9</accession>
    <name>A0A2G1X9X9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_31755</name>
        <name evidence="9" type="ORF">CYQ11_24810</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48030">
        <property type="protein sequence ID" value="PHQ48030"/>
        <property type="gene ID" value="BLA24_31755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15656">
        <property type="protein sequence ID" value="PPT15656"/>
        <property type="gene ID" value="CYQ11_24810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="12"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="442" mass="46905" checksum="271E999B9D3A9345" modified="2018-01-31" version="1">MTTTDMVGLAAASLLRFATAGSVDDGKSTLVGRLLHDSKSVLADQLDAVERASRHRGAAAPDLALLTDGLRAEREQGITIDVAHRYFATPRRRFILADTPGHVQYTRNMVTGASTAGLAVVLVDARNGVVEQTRRHAAVAALLRVPHVVLAVNKMDLVGYAESVFAAIAGEFTAYASRLGIGEVTAIPVSALAGDNVVVPSAHMDWYGGPTVLEHLESVPVGTDPTTSAARFPVQYVIRPQTPGHRDYRGYAGQIACGVFRVGDRVAVLPSGRTSTITAIDALGTSVDLAWAPQSVTLRLADDLDISRGDLITPTTSAPPTTRDIEATVCHLADRPLRTGDRVLLKHTTRTVKAIVKDLPSRLSLDDLTHTPHPTHLTANDIGRITLRTSEPLALDPYTNSRHTGSFLLIDPTDGTTLTAGMAGTSFAAPAAPVSTDGEWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA67</accession>
    <name>A0A2G1XA67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32260</name>
        <name evidence="4" type="ORF">CYQ11_25315</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48113">
        <property type="protein sequence ID" value="PHQ48113"/>
        <property type="gene ID" value="BLA24_32260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15738">
        <property type="protein sequence ID" value="PPT15738"/>
        <property type="gene ID" value="CYQ11_25315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007136">
        <property type="entry name" value="DUF347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03988">
        <property type="entry name" value="DUF347"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="29541" checksum="1CD4B54E5B31664D" modified="2018-01-31" version="1">MTPEISETAETLATHTAPAPGAGPGRRWNKVPEVTVYFWVIKVLCTTVGETAADLLNGNLGLGLSGVSLLMSALLVVALVVQFRVRAYRPGLYWLVVALVSVVGTLITDNLTDNMGVPLQVSTAVFAAALVGVFAVWYRSERTLSIHHVDTTRREAFYWAAVLCTFALGTAAGDLVAERMALGYWLSAGLFALAIAAVAVAHYALGLDAVWSFWIAYVLTRPLGASVGDYLSQPAADGGLGLGTVATSGLFLAVITGLVVFLTVTRRDVTARESLTPQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA69</accession>
    <name>A0A2G1XA69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31920</name>
        <name evidence="3" type="ORF">CYQ11_24975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48059">
        <property type="protein sequence ID" value="PHQ48059"/>
        <property type="gene ID" value="BLA24_31920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15685">
        <property type="protein sequence ID" value="PPT15685"/>
        <property type="gene ID" value="CYQ11_24975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="29717" checksum="82838C21CC56A864" modified="2018-01-31" version="1">MTIDRNIQEINRTMWSYGEYRHVADLLRPGAADLVERLAPGPGTRHLDVATGNGNVALLSALRGAVVDGLDLTDEFFPDARTRFDQAGVTVDLHRGDAQELPFPDASFDLVTSTYGVQFAPDHTAAAGEMARVLCPGGRVGMCNWTARSWTAHFQAVLSSYFPSAAGHQGQPMLWGDPDYLTELFGPGCAVTAERRELFYAFPSADDLISFFATCFGPFIAAKNTIAPPSRWKELRAELVEMTEQFHTTDERGTGVPVEYLLAVVETRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD3</accession>
    <name>A0A2G1XAD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32780</name>
        <name evidence="4" type="ORF">CYQ11_25830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48197">
        <property type="protein sequence ID" value="PHQ48197"/>
        <property type="gene ID" value="BLA24_32780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15823">
        <property type="protein sequence ID" value="PPT15823"/>
        <property type="gene ID" value="CYQ11_25830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="298" mass="32312" checksum="01EBAEB4E02F47B1" modified="2018-01-31" version="1">MFDPVHLRTFLAVAQTLSFTQAGHRLGLRQSTVSQHVRRLEEAAGRQLFARDTHSVALTEDGEAMLGFARTILEANERAAHWFAGTRLRGRLRFGASEDFVLTRLPEILESFRRDHPEVDLELTVGLSGTLQEQVAAGRLDLVLVKRHPDVPLPGRGRLVWRDRLVWIGGERLRLDAHRPLPLVLLPPPAVTRARALEVLERHGRPWRVTCTSGSLNGLVAAARAGLGVMAHAEGMRPPGLVRVPARAGLPELGGIDVVLLYGADALRDGSVRGSAEALAAAVLAAGDRLHAPAAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAK0</accession>
    <name>A0A2G1XAK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Laminin G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32790</name>
        <name evidence="7" type="ORF">CYQ11_25840</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48199">
        <property type="protein sequence ID" value="PHQ48199"/>
        <property type="gene ID" value="BLA24_32790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15825">
        <property type="protein sequence ID" value="PPT15825"/>
        <property type="gene ID" value="CYQ11_25840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="5">
        <location>
            <begin position="463"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="4">
        <location>
            <begin position="463"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="655" mass="69907" checksum="85729E489B5BA78F" modified="2018-01-31" version="1">MRDGRVIRALRARPGLSTLLATGGALLALLPHPAFPQPARDLAPFEEQVLFRADLDPGYACYRIPAVVTTTRGTLLAFAEGRKENCGDATDIDLVLKRSTDGGRTWGPLQVVDPGDGDTHGNPAPVVDRRTGRIVLATTYNKGREDAGNCDVPCDRTPHLQHSDDDGLSWSRPRDLSAQIRPRGWNSWYATGPGHGIQLAGGPRRGRLVIGVNAESHDGGHTSANHAALVLSDDGGEHWRLGALDSYPVGSDDTYRQKPSELTLAERGDGAVYVNGREQNGTELGNRDEAVSRDGGASFTAPFRALPGLYSPMVQGAVAPLRPGRWLLSLPADPDRRRTMTIRSSYDQGRTWESAELGRRVTADWSGYSDMAVIAPGTTGLLYEAGKADARQEIRFARFTEEWLGLRRDPGPTTPDRAPGGRDGQLLGAPRLVGGRFGGALSFDGKDSAVRVPYRPSLPLGTRDFTAVLWFRYRAGRGEQPFLWMGGMGGAPQVALRGEPGERRIAGQVTAVTGAGPARTVTVRSAGAYDDGKWHQLALRRTGDQVTLTVDGVSTVAPGVPGTVARNSTFGVHVGQKPDGRASLTGDLDEVRVYGRALTDGELRALRGANALPGAPERRGVSGEAPGAGTAGREPVLWLPLDRIRRVGGPDRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAL0</accession>
    <name>A0A2G1XAL0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33055</name>
        <name evidence="3" type="ORF">CYQ11_26105</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48245">
        <property type="protein sequence ID" value="PHQ48245"/>
        <property type="gene ID" value="BLA24_33055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15872">
        <property type="protein sequence ID" value="PPT15872"/>
        <property type="gene ID" value="CYQ11_26105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017830">
        <property type="entry name" value="SQase_HpnE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03467">
        <property type="entry name" value="HpnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="486" mass="51493" checksum="E7BC815D9C833E3B" modified="2018-01-31" version="1">MTSETTTRHGRLPAHEAGRPEGAAAVVIGGGLAGVTAALELADAGLRVTLLEGRPRLGGLAFSFQRGELTVDNGQHVYLRCCTAYRWFLDRLDARALAPLQDRLDVPVLDVGRPSGRPRLGRLRRTALPVPLHLAASLATYPHLSVAERAGVGRAALALRGMDPLDPALDDVDFGSWLRRHGQSARTVEALWDLVGVATLNATAEHSSLGLATMVFKTGLLSEPGAADIGWAHVPLGELHDTRARAALDRAGVRTALRTRATRISAHPEGGWQVDTAAGPGTAGRLAADTVVLAVPQREAHGLLPEGALDEPGRLLGIGTAPILNLHVVYDRKVLRQPFFTALGSPVQWVFDRTDSSGLAAADPGAQYLAVSQSAAQDDIDRPVAELRERYLPELERLLPAARGAVVKDFFVTRERTATFAPTPGVGRLRPHAPTNAPGLYLAGAWTATGWPATMESAVRSGLNAAGAALSELGRPHRNPVREAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP1</accession>
    <name>A0A2G1XAP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33385</name>
        <name evidence="3" type="ORF">CYQ11_26435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48296">
        <property type="protein sequence ID" value="PHQ48296"/>
        <property type="gene ID" value="BLA24_33385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15927">
        <property type="protein sequence ID" value="PPT15927"/>
        <property type="gene ID" value="CYQ11_26435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="11744" checksum="0993E00B9E8198D3" modified="2018-01-31" version="1">MAYDEVLAERVRELLEETDAVVAKKMFGGLVFTVRGNTAVGVVGDDLLVRVTPDDTPQSLAQPGARPYKFRGRISKGWVLVAGEVLDDDVLDDWLHLGRKAAAALPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX7</accession>
    <name>A0A2G1XAX7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32170</name>
        <name evidence="3" type="ORF">CYQ11_25225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48362">
        <property type="protein sequence ID" value="PHQ48362"/>
        <property type="gene ID" value="BLA24_32170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16788">
        <property type="protein sequence ID" value="PPT16788"/>
        <property type="gene ID" value="CYQ11_25225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="27110" checksum="4C99E7B6C0625A02" modified="2018-01-31" version="1">MAKQQPLQFTLDRGSPVPLYFQLSQQLEAAIEQGRLAPGSLLGNEIDLAGRLGLSRPTVRQAIQSLVDKGLLVRRRGVGTQVVHSQIKRPLELSSLYDDLDAAGQKPATRVLRHAVEPASAQVAAALGVAEGADVLLVERLRLAHGEPMAHLRNHLPVGLLELEGGEALERSGLYRLMRTAGITLHSARQTIGARAATAEEGELLAEPEGAPLLTMERTTFDDTGRAVEFGSHLYRASRYSFDFQLLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBB8</accession>
    <name>A0A2G1XBB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29690</name>
        <name evidence="7" type="ORF">CYQ11_05785</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48528">
        <property type="protein sequence ID" value="PHQ48528"/>
        <property type="gene ID" value="BLA24_29690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12473">
        <property type="protein sequence ID" value="PPT12473"/>
        <property type="gene ID" value="CYQ11_05785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="363" mass="37852" checksum="F57AC3D7DEFD1F7A" modified="2018-01-31" version="1">MTDVEQDGPSSSGHEGRDGRRWPTVRGPHAATARATSRDVARAAGVSQATVSLVMGDKWRGRVSEPTAEAVRAAARDLGYRPNLAARNLRLGRTRTALLVVPALTNEFFARVYTGAARAATDHGVGVVLYPSPEGTGPARDPFASARAALDGVIASSMAADALADIREGDLPLVMLDSDPERTDAATTVNLDIADGIRQVTNHLLALGHRHFAHIAADIDSWTFRVRARALADALHGSTGDVVRTETATLDVTAGRLAAERALTGPGPRPTALICDSDTLAAGACKAARRLGLRVPQDVSVTGFDDLPLATALEPELTTVRLPAEEVGAAGMRALVATLDGRPVTPTALPVELVTRGSTTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBC7</accession>
    <name>A0A2G1XBC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29725</name>
        <name evidence="2" type="ORF">CYQ11_05750</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48533">
        <property type="protein sequence ID" value="PHQ48533"/>
        <property type="gene ID" value="BLA24_29725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12467">
        <property type="protein sequence ID" value="PPT12467"/>
        <property type="gene ID" value="CYQ11_05750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="82" mass="8545" checksum="1F5E9F9F4931875C" modified="2018-01-31" version="1">MTQTSVTAVAAAVFKAACPDCRGRFELAAGALRLAIGASDRTTFYSFTCPDCGSAVRKPAGERIVELLTGGGVRTLRLHITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC02</accession>
    <name>A0A2G1XC02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27135</name>
        <name evidence="5" type="ORF">CYQ11_18520</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48756">
        <property type="protein sequence ID" value="PHQ48756"/>
        <property type="gene ID" value="BLA24_27135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14596">
        <property type="protein sequence ID" value="PPT14596"/>
        <property type="gene ID" value="CYQ11_18520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="505" mass="53483" checksum="3DC5F3F14A19806F" modified="2018-01-31" version="1">MERTWATYGPGDAEPETGRPGEPEGTPAPGATADVPGAVGADLHLDLADAPGRGVRAALTRALREAVRSGRLAPGVRLPSSRSLAADLGLARNTVADAYGELVAEGWLTARQGSGTRVAQRTAPVPRRGGRRPAPPRGGARPLHDLRCGAADVSVFPRAAWLAAARRALAVAPHEAFGYGDGRGRPELRTALADYLARARGVRADPEHIVVCAGFSQGLALLGRLLRERGVRGMGVESYGLWFHHGIVERAGLRPRPMSLDRRGARVGELDEGDVPGAVLLTPAHQFPTGVALHPDRRAAVVDWAARTGGVVVEDDYDGEFRYDRQPVGALQGLAPEHVVYCGTAGKALAPGVRLAWLVLPDHLLGDLLELKATGEWGLSALDQLTLAEFIEAGAYDRHVRAMRLRYRRRRDQLVSALAERAPHVRVTGIAAGLHAVLELPPGTERSTVQAAAWQGLALEGLDRFRHPQAPAPAPGDGLIVAYGTPPDHAFPGALEALLGVLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC61</accession>
    <name>A0A2G1XC61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27720</name>
        <name evidence="4" type="ORF">CYQ11_17920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48854">
        <property type="protein sequence ID" value="PHQ48854"/>
        <property type="gene ID" value="BLA24_27720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14499">
        <property type="protein sequence ID" value="PPT14499"/>
        <property type="gene ID" value="CYQ11_17920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13670" checksum="5F97D952AD017CD3" modified="2018-01-31" version="1">MPTGKVKWFNSEKGFGFLSRDDGGDVFVHSSVLPDGVDALKPGQRVEFGVVAGQRGDQALTVTLLEPAPSLAAAQRRKPDELASIVQDLTTLLENVTQQLERGRYPDKAHGSKIAGMLRAVADQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCF2</accession>
    <name>A0A2G1XCF2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoacyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28000</name>
        <name evidence="5" type="ORF">CYQ11_17640</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48902">
        <property type="protein sequence ID" value="PHQ48902"/>
        <property type="gene ID" value="BLA24_28000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14449">
        <property type="protein sequence ID" value="PPT14449"/>
        <property type="gene ID" value="CYQ11_17640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="141" mass="15936" checksum="FBC4228DA2AD7039" modified="2018-01-31" version="1">MSGPHVIRGSVSLPEAELVWRFSRSSGPGGQHVNTTDSQVELRFDLANTTALPEVWKERALERLASRLVDGVVSVRASEHRSQWRNRETAAVRLAALLAEASAPPPRKRRPTKIPRGINERRLREKKQRGETKRGRSGRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCF5</accession>
    <name>A0A2G1XCF5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">BLA24_27245</name>
        <name evidence="10" type="ORF">CYQ11_18410</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48923">
        <property type="protein sequence ID" value="PHQ48923"/>
        <property type="gene ID" value="BLA24_27245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14576">
        <property type="protein sequence ID" value="PPT14576"/>
        <property type="gene ID" value="CYQ11_18410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="319"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="41010" checksum="F3FD77421AD95BDC" modified="2018-01-31" version="1">MDLFEYQARDLFAKHGVPVLAGEVIDTPEAARAATERLGGKSVVKAQVKVGGRGKAGGVKLAATPDEAVARATDILGMDIKGHTVHKVMIAETAPEILEEYYVSYLLDRTNRTFLAMASVAGGMDIEEVAATTPEKLAKVPVDANEGVSIEKAREIVAQAKFPAEVAEKVAEVMVTLWKTFVAEDALLVEVNPLAKVASGDVIALDGKVSLDENADFRQPEHEALEDKASANPLEAAAKAKGLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGENHGGVKPANFLDIGGGASAEVMANGLEIILGDPDVKSVFVNVFGGITACDEVAKGIVQALELLKDKGEDVTKPLVVRLDGNNAELGRKILSDANHPLVQRVDTMDGAADKAAELAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCL5</accession>
    <name>A0A2G1XCL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27885</name>
        <name evidence="2" type="ORF">CYQ11_17755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48941">
        <property type="protein sequence ID" value="PHQ48941"/>
        <property type="gene ID" value="BLA24_27885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14470">
        <property type="protein sequence ID" value="PPT14470"/>
        <property type="gene ID" value="CYQ11_17755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="13071" checksum="13C048E97B269ED0" modified="2018-01-31" version="1">MELEQALHTARALILADLAAGDVAEADVVSLVEDAVAHRRWWVEQWPEGMAFLPGLVAQDVQDALLERYGRWPLCPVCTGNGELHALEVEPELGADPHWACAKQAVLVARVGSLGTVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT3</accession>
    <name>A0A2G1XCT3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">BLA24_23315</name>
        <name evidence="3" type="ORF">CYQ11_22760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49028">
        <property type="protein sequence ID" value="PHQ49028"/>
        <property type="gene ID" value="BLA24_23315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15326">
        <property type="protein sequence ID" value="PPT15326"/>
        <property type="gene ID" value="CYQ11_22760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="8702" checksum="68E0262D31A1BC49" modified="2018-01-31" version="1">MLEEALEHLVKGIVDNPDDVQIASRNLRRGRVLEVRVHPDDLGKVIGRNGRTARALRTVVGAIGGRGIRVDLVDVDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD17</accession>
    <name>A0A2G1XD17_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_23830</name>
        <name evidence="10" type="ORF">CYQ11_22240</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49112">
        <property type="protein sequence ID" value="PHQ49112"/>
        <property type="gene ID" value="BLA24_23830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15240">
        <property type="protein sequence ID" value="PPT15240"/>
        <property type="gene ID" value="CYQ11_22240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="3"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="389" mass="40049" checksum="21337DFF3631125C" modified="2018-01-31" version="1">MAYLDHAATTPMLPEAVQAMTAQLPLAGNASSLHAAGRRARRTVEEARESLAASLGARPSEVVFTAGGTEADNLAVKGLFWARRAADPARTRVLASPVEHHAVLDAVDWLATHEGATVEYLPVDSYGRVHADALREAIARNPDDVALATVMWANNEIGTVMPVRELADVAAESGVPLHSDAVQAVGQLDVGFAASGLAAMTVSSHKIGGPYGVGALLLGRQYAPVPLLHGGGQERHVRSGTLDVPAIAAFAVAGTLAAERREAFAREVGALRDELIAGVRAAVPDAVLGGDPDPAGRLPANAHFSFPGCEGDSLLLLLDARGIECSTGSACTAGVAQPSHVVLATGTDPELARGTLRFSLGHTSTRDDVAAVVEAIGPVVERARTAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD92</accession>
    <name>A0A2G1XD92_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_24295</name>
        <name evidence="7" type="ORF">CYQ11_21775</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49190">
        <property type="protein sequence ID" value="PHQ49190"/>
        <property type="gene ID" value="BLA24_24295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15160">
        <property type="protein sequence ID" value="PPT15160"/>
        <property type="gene ID" value="CYQ11_21775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="401" mass="42168" checksum="DA5B110E7D51E27E" modified="2018-01-31" version="1">MIEAVGLTKRYGAKTAVHNLSFHVRPGMVTGFLGPNGSGKSTTMRMIVGLDVPTSGRVTIGGLPYHKLPNAPRQVGALLDAKAVHGGRSARTHLLSLAQLGGIPAQRVDEVLDVVGLREVAKKRTRGFSLGMGQRLGIAAALLGDPQVLLFDEPVNGLDPEGILWVRNLMKRLAAEGRTVLVSSHLMSEMALTADHLIVIGRGQLMADMSVKDFISANSSDFARVRTPEGEPEAREKLTSALVEAGGRVLPEQDGALRVVGLALPRISDVAHGADVRLWELSPHQASLEEAYMRMTQGAVDYRSTADQRAGFQAPAQPGWQPYAPAPAVRPEQAYPALPGEQPNPYAQGAPQPPQAAPPAVPVPAAPSGAPATGPAPATPQAKPAAAAPADLTKRDSQDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDH7</accession>
    <name>A0A2G1XDH7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">BLA24_24825</name>
        <name evidence="14" type="ORF">CYQ11_21245</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004937597.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49286">
        <property type="protein sequence ID" value="PHQ49286"/>
        <property type="gene ID" value="BLA24_24825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15063">
        <property type="protein sequence ID" value="PPT15063"/>
        <property type="gene ID" value="CYQ11_21245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ49286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="85" mass="9658" checksum="9D30CEC1E098A00C" modified="2018-01-31" version="1">MDWRHNAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQCLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDP5</accession>
    <name>A0A2G1XDP5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rsgA</name>
        <name evidence="7" type="ORF">BLA24_24970</name>
        <name evidence="8" type="ORF">CYQ11_21100</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49311">
        <property type="protein sequence ID" value="PHQ49311"/>
        <property type="gene ID" value="BLA24_24970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15039">
        <property type="protein sequence ID" value="PPT15039"/>
        <property type="gene ID" value="CYQ11_21100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="99"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="118"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="209"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="334" mass="36694" checksum="C2A6AA0FF96F7C39" modified="2018-01-31" version="1">MRRYGKHTDEDDVRVRPNRKGNRPRTTIRPKHEDAAEGFVLTVDRGRLTVLVEDRTVLAMKARELGRKGVVVGDRVAVVGDLSGAKDTLARIVRVETRSSVLRRTADDDDPYERVVVANADQLAIVTALADPEPRPRLIDRCLVAAYDAGLEPLLVLTKSDLASAETLMESYGSLGTRYVVTSRDELAEGTAARQVREQLEGRITAFVGHSGVGKTTLVNALVERQRATGHVNAVTGRGRHTTTSALALPLPDGTGWVIDTPGVRSFGLHHVDPSRVIHAFPDLEPGTEECPRACSHDEQDCALDQWVADGHADPQRLYSLRRLLATRERREGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDT7</accession>
    <name>A0A2G1XDT7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_25485</name>
        <name evidence="5" type="ORF">CYQ11_20590</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49400">
        <property type="protein sequence ID" value="PHQ49400"/>
        <property type="gene ID" value="BLA24_25485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14950">
        <property type="protein sequence ID" value="PPT14950"/>
        <property type="gene ID" value="CYQ11_20590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758485" evidence="2">
        <location>
            <begin position="31"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="125"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="603" mass="65581" checksum="3FC583CDAC081548" modified="2018-01-31" version="1">MTPTSRFPQHRARFSVMVLAAGALTLSACSSGGGGGGGGKSQGPGEDKNKSSNYSIGTKEDSTGPAPDVAGAKEAKKGGTVTVLQRDAFVHLDPGQIYYSDMLANQMLYNRSLTSYKVDAQGKVKVVGDLATDAGTASDGGKTWKFTLKDGLKFEDGSAITAKDVRWGVERLYASFETDGPLYIPQWLSGDGTDFRKALPDGPYGGQHLPASVLDTPDDKTVIFHFRQPHADTPFATAMPNVGAVKAEKDTKQKYDNAPFSSGPYKVGDYKAGKSLTLVRNENWDPKTDPIRHQYADRFEISFGHQYADSTRRFLADQGGDKTALSFSNAVAPEMTEKVLGQADTKARRFVEIQPYVDYISFNTSRLTDVKVRKALAYAMPNGQILQQNGGETGGVVATNFLSPAMDGYQPTDPFGKKAKPAGDPEKARQLLKEAGKEGQEIVFAYPNTDIQQRVSVVIAQALERAGFKVQKKEVDANTWRTAIAEVKNKFDVYRTSWGADWPVSSTVVPPLFDGRQIADGSQNYGHLDDPKVNAEVDRINAIPDVKQAAPEWQKLADKILTEDVPGVPTFYNRLFTLWGSKLGGVTYHPVYGTVDPTGVYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE53</accession>
    <name>A0A2G1XE53_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26095</name>
        <name evidence="4" type="ORF">CYQ11_19545</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49508">
        <property type="protein sequence ID" value="PHQ49508"/>
        <property type="gene ID" value="BLA24_26095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14772">
        <property type="protein sequence ID" value="PPT14772"/>
        <property type="gene ID" value="CYQ11_19545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="203" mass="21445" checksum="A69E5011D4B95318" modified="2018-01-31" version="1">MEQPSTRIPQRKVRRGSPVPRPAAPVGQRRDPAGTPVRRGRPGRSAVPLSRLPAARLTGLGSGLLTALAMLGVGALDALLLGGSPEVYGVFFLIGSAACALWVRPAELMTAPVSVPIAYAVGAVPLGESTEGVAGRLMSMVTLLSLTAGWLYAGTLLAALIALVRRVLLIRTRRRARNRLRQRPSRRPRSPRCSGAGPGRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEA1</accession>
    <name>A0A2G1XEA1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_26385</name>
        <name evidence="7" type="ORF">CYQ11_19255</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49556">
        <property type="protein sequence ID" value="PHQ49556"/>
        <property type="gene ID" value="BLA24_26385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16669">
        <property type="protein sequence ID" value="PPT16669"/>
        <property type="gene ID" value="CYQ11_19255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="24667" checksum="DED64A84E74F6901" modified="2018-01-31" version="1">MTPAPTAALDAVAVPAPPPVKPRLRGWLHAGMFPAVLIAGVFLTALADSTRGRIACAVYVLTACLLFGISALYHRGDWSPRTTAVLRRLDHANIFLIIAGTYTPLTMLLVPGGRGQALLWAVWAAATAGIAFRVFWVGAPRWLYLPCYIAMGWAAVFFLPDFLHRGGIAVLVLVIVGGLLYSAGGVIYGVKRPNPSPRWFGFHEVFHSFTLAAFIAHYVGISLVAYSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC2</accession>
    <name>A0A2G1XEC2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">BLA24_26470</name>
        <name evidence="7" type="ORF">CYQ11_19170</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49572">
        <property type="protein sequence ID" value="PHQ49572"/>
        <property type="gene ID" value="BLA24_26470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14709">
        <property type="protein sequence ID" value="PPT14709"/>
        <property type="gene ID" value="CYQ11_19170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="46"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="23072" checksum="2AD599258563D58B" modified="2018-01-31" version="1">MSPNRQQNPEGPLKGRPAPQFALQERHTVLGNPLAPPYPEGLAVADFGLGCFWGAERIFWQTEGVWTTLVGYQGGGTQHPAYEEVCSGLTGHAEVVRVVFDPSVVPYETLLKVFWESHDPTQGNRQGNDVGTQYRSAIYTHSPAQQSAAESSRTAYQPVLTSAGYGPITTEIAPAPPFFHAEAYHQQYLAKNPAGYCGIGGTGVSCPVGVAPAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE8</accession>
    <name>A0A2G1XEE8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26650</name>
        <name evidence="5" type="ORF">CYQ11_18985</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49603">
        <property type="protein sequence ID" value="PHQ49603"/>
        <property type="gene ID" value="BLA24_26650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14677">
        <property type="protein sequence ID" value="PPT14677"/>
        <property type="gene ID" value="CYQ11_18985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="3">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="19535" checksum="8F31F6D852263331" modified="2018-01-31" version="1">MQRHGYGGTPALRYRYRVAGCVLLTVQLLVVGWLALRPLTAPWVSAARLEPLATIRADLALSPWDAARSIGAGVLPFAPLGVLLPWAGGRIAVSALGSLARTLFTAVMLSLALQVVQSGVVGQVLDVDKLLMNVTGVALAHVAVVPAVRARLRRRAEGRPTPPLRRKEPDRGLTPTIPRVGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEH3</accession>
    <name>A0A2G1XEH3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26660</name>
        <name evidence="3" type="ORF">CYQ11_18975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49605">
        <property type="protein sequence ID" value="PHQ49605"/>
        <property type="gene ID" value="BLA24_26660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14675">
        <property type="protein sequence ID" value="PPT14675"/>
        <property type="gene ID" value="CYQ11_18975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304831" evidence="1">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="12429" checksum="A6116ADF9BE4D47A" modified="2018-01-31" version="1">MKQATLKALGAVAVGAAIAASAAGTASAGTLESVTTTATGATKGLPIEQVAPIAPAGGPVLVATNRLIASGVLEQTAKAADHALAPHLPTEKLAAPTDNKGNAGLLGGLPTKAIAPNGISLPGIGTPNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XES7</accession>
    <name>A0A2G1XES7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25250</name>
        <name evidence="3" type="ORF">CYQ11_20820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49730">
        <property type="protein sequence ID" value="PHQ49730"/>
        <property type="gene ID" value="BLA24_25250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16695">
        <property type="protein sequence ID" value="PPT16695"/>
        <property type="gene ID" value="CYQ11_20820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="91" mass="9255" checksum="B63A571E91DBDDD7" modified="2018-01-31" version="1">MLWEALGSVLIGLAVSYGALRWLPARLGQFRSRPLALSTGPASALFGALLAHSVLGAGHTLAVLAVALGVAVALVSLLLRPGSRARRSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF03</accession>
    <name>A0A2G1XF03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19400</name>
        <name evidence="3" type="ORF">CYQ11_11400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49816">
        <property type="protein sequence ID" value="PHQ49816"/>
        <property type="gene ID" value="BLA24_19400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13408">
        <property type="protein sequence ID" value="PPT13408"/>
        <property type="gene ID" value="CYQ11_11400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="15730" checksum="470B45F28761D239" modified="2018-01-31" version="1">MPTPEAATVAAELRIAMGKLTRRVKQEDRIPHGQVAVLGVLDRDGAMTTSDLAADQRVRPQSMARAVGLLLEQGLVTRRAHPTDGRKSLVELSDAGRVALEAERGRRAGWLALAIEAELTESEREVLARSAALMERLAAGQGLSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF15</accession>
    <name>A0A2G1XF15_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19450</name>
        <name evidence="3" type="ORF">CYQ11_11350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49823">
        <property type="protein sequence ID" value="PHQ49823"/>
        <property type="gene ID" value="BLA24_19450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13402">
        <property type="protein sequence ID" value="PPT13402"/>
        <property type="gene ID" value="CYQ11_11350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="8241" checksum="DD0C0A1400528D07" modified="2018-01-31" version="1">MVKGVLWGVYILATGIAATGAGALAAAVAGGSVLVHVVFSVLVVLVAGWIAPAVISLTLHLLRRSRPAAPRPRRHVGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF65</accession>
    <name>A0A2G1XF65_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-dependent thiol peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19740</name>
        <name evidence="3" type="ORF">CYQ11_11050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49873">
        <property type="protein sequence ID" value="PHQ49873"/>
        <property type="gene ID" value="BLA24_19740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13351">
        <property type="protein sequence ID" value="PPT13351"/>
        <property type="gene ID" value="CYQ11_11050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="155" mass="16787" checksum="C305BDDA7F41F9D7" modified="2018-01-31" version="1">MSERLQPGDTAPAFTLPDADGKQVSLADRKGRKVIVYFYPAALTPGCTKQACDFTDNLAFLAGHGYDVIGVSPDKPEKLAKFREQEDLKVTLVGDPEKKVLTAYGAFGEKKLYGKTVTGVIRSTVIVDEDGKVERALYNVKATGHVAKIIKDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFG3</accession>
    <name>A0A2G1XFG3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20355</name>
        <name evidence="3" type="ORF">CYQ11_10430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49972">
        <property type="protein sequence ID" value="PHQ49972"/>
        <property type="gene ID" value="BLA24_20355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13251">
        <property type="protein sequence ID" value="PPT13251"/>
        <property type="gene ID" value="CYQ11_10430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041654">
        <property type="entry name" value="StyA_sbd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17885">
        <property type="entry name" value="Smoa_sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smoa_sbd" evidence="1">
        <location>
            <begin position="146"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="414" mass="44500" checksum="271F13B90FC1B44B" modified="2018-01-31" version="1">MRRIAIVGAGQAGLQLALGLRAADYDVTVFSARKAAEIRTGRVMSSQLMYGPALALERRAGLNLWDAATPPIGGLQLTLVDPPGVRSVTISSALDEPAQSVDQRLKTAHWLELLEERGGRVEYRPVAADELAATASAYDLTLVATGHGPLAEVFGRDERHSPYDSPQRALACLYLHGVMPDTRQPPGYARVCAVPGTGEYFLLPALTVSGPCDIMLWEGHPGGPFDCWSDGPDPGAALARSLELLRSYAPWEYELCAAAQPTDARAVLTGGLTPVVRHPVAEVAPGSYVLGMSDAVVLNDPVTGQGSNNAARCAARYLDAIVERGERPFDRAWMHETFAVWWEHARHGTAFTNMVLGPHPEHFQRVLAAASEHPGIAHRYVNGYADPADYQDWLMDADRAEACLAAVAGRPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFM1</accession>
    <name>A0A2G1XFM1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20695</name>
        <name evidence="5" type="ORF">CYQ11_10085</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50032">
        <property type="protein sequence ID" value="PHQ50032"/>
        <property type="gene ID" value="BLA24_20695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13190">
        <property type="protein sequence ID" value="PPT13190"/>
        <property type="gene ID" value="CYQ11_10085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="162" mass="17908" checksum="768F96F5E38ABD9D" modified="2018-01-31" version="1">MRVYLGSDHAGYELKNHLVEWLKAQGHDPVDCGPHIYDAQDDYPPFCLRAAERTAADEGSLGIVIGGSGNGEQIAANKVEGVRAALAWSEQTAALGREHNDANVMSVGARMHTEDEATKFVEIFLATPYSGDERHTRRIEMLSRYERTGELPEIPAHHPQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN4</accession>
    <name>A0A2G1XFN4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ORF">BLA24_20805</name>
        <name evidence="12" type="ORF">CYQ11_09975</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50048">
        <property type="protein sequence ID" value="PHQ50048"/>
        <property type="gene ID" value="BLA24_20805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13173">
        <property type="protein sequence ID" value="PPT13173"/>
        <property type="gene ID" value="CYQ11_09975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23899" checksum="D60260FA736CFD36" modified="2018-01-31" version="1">MNISSPSGLYTGPQAEARYVVPRFVERTSQGVREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESMDPDRDISIYINSPGGSFTALTAIYDTMQFVKPDIQTVCMGQAASAAAILLAAGTPGKRMALPNARVLIHQPSSQTGREQLSDLEIAAKEIMRMRTQLEEMLAKHSTQPIEKIRDDIERDKILTAEESLAYGLVDQIVSTRKSSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG09</accession>
    <name>A0A2G1XG09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21600</name>
        <name evidence="5" type="ORF">CYQ11_09185</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50173">
        <property type="protein sequence ID" value="PHQ50173"/>
        <property type="gene ID" value="BLA24_21600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13044">
        <property type="protein sequence ID" value="PPT13044"/>
        <property type="gene ID" value="CYQ11_09185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="170"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="294" mass="30271" checksum="46FA867187622451" modified="2018-01-31" version="1">MSETRTTSVAVLGTGIMGAAMARNLARAGLSVRAWNRSREKAEPLAAHGVGVEDTPAAAVRDADVVVTMLYDAPATLDAMRAAAPGLRPGTVWAQSATAGLDGFGDLAAFARERGLTLVDAPVLGTRQPAEEGRLTVLAAGPEDVRTVVAPVFDAVGARTVWVGDDAATGAATRLKLVVNSWILAVTHGTAEALALAEGLAVRPEQFLDAVAGGPLDMGYLRAKAGLLLDGALTPPSFATTTAEKDARLIVEAGRAAGVRLDVAAAGAERFRRAVEQGHGDEDMAASYFASFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG41</accession>
    <name>A0A2G1XG41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extradiol dioxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21770</name>
        <name evidence="3" type="ORF">CYQ11_09015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50203">
        <property type="protein sequence ID" value="PHQ50203"/>
        <property type="gene ID" value="BLA24_21770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13013">
        <property type="protein sequence ID" value="PPT13013"/>
        <property type="gene ID" value="CYQ11_09015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="14337" checksum="0449D4D4DD8F216C" modified="2018-01-31" version="1">MAYLGLVTVVVRDYDEALAFYTDAAGFELREDTPLGDGKRWVVVAPPGSKETGVLLARADGPAQQARVGDQTGGRVGLFLTTDDFARDHERMRAAGVHFEEEPRHEPYGTVVVFQDLYGNRWDLIGPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG63</accession>
    <name>A0A2G1XG63_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lytic transglycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21925</name>
        <name evidence="5" type="ORF">CYQ11_08860</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50230">
        <property type="protein sequence ID" value="PHQ50230"/>
        <property type="gene ID" value="BLA24_21925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12985">
        <property type="protein sequence ID" value="PPT12985"/>
        <property type="gene ID" value="CYQ11_08860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="20899" checksum="5D080BB303202A69" modified="2018-01-31" version="1">MPPRRRPPNSGGVGGSVLRKTPVHGGLCQVPRASARLVEPPGSTSLRRHASAPDGRFSFVTFRTINRKASRKLVAAAGAALVLGTAGAVLTAVPAHAAAPSTTATQDIARKMIGDEAQFQCFSKIVEHESGWKHTATNASSGAYGLVQALPGSKMASAGADWQTNPATQIKWGMDYMKDRYGSPCGAWSFWSAHHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG88</accession>
    <name>A0A2G1XG88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21875</name>
        <name evidence="2" type="ORF">CYQ11_08910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50221">
        <property type="protein sequence ID" value="PHQ50221"/>
        <property type="gene ID" value="BLA24_21875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12995">
        <property type="protein sequence ID" value="PPT12995"/>
        <property type="gene ID" value="CYQ11_08910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="218" mass="22751" checksum="F364F46F115FBEA9" modified="2018-01-31" version="1">MTTLTARALLLDMDGTIVNSDAVVERCWRRWAEEHGLDADEALKVVHGRQGYATMAVLLPDRPMELNHEDNRRMLAAETADMDGVVPVPGAPAFMAALAALPHALVTSADRKLAEARMGAAALPMPAVRVTAECVSASKPDPEGFLKGAAELGFAPEDCVVFEDSEAGIAAGKAAGMRVVGVGPRAAAHAPDAHVMTLEQVRVEAGPDGAITLRIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGA7</accession>
    <name>A0A2G1XGA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1906 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22140</name>
        <name evidence="4" type="ORF">CYQ11_08645</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50257">
        <property type="protein sequence ID" value="PHQ50257"/>
        <property type="gene ID" value="BLA24_22140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12957">
        <property type="protein sequence ID" value="PPT12957"/>
        <property type="gene ID" value="CYQ11_08645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304860" evidence="2">
        <location>
            <begin position="33"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="686" mass="71254" checksum="E843458D57911047" modified="2018-01-31" version="1">MMSSKHVRGLATLVAAAAVLAAPLVSAGSALAATPAGQGGAPVSYQGLSLDVPAGWNVVNLDDHPDTCVRLDQKTLYLGHPGANQNCPTHLVGQKTDALVVEPVSGAAPRPDVPTVNVAAGQQVPGTLPTDDGREVRVAFEGAGLFATASYEGSTAAVQKILSSAKLDKSAKPAAAPKPSRAPLAAAAAAVTPSTGFTGKAFDACAAPSNSTMSDWADSPYRGVGIYIGGPTRVCAQPNLTSSWVQTQTRAGWHMLPIYAGTQAAGISSGNATGQGRAAAEKAVELAKDLGFAPGTVLYVDMENYSPGYRANVLNYLSGWSDRIRELGFRSGVYGSASSAMKDLSSVYNNDSYHRPDVVWSANWNSKADTDDSYIPDGYWSHHQRVHQYAGEVSESHGGTQLNIDRDYVDVAPSLGDPGMTQLTAGDLNADGKKDVVAVKVETGELFLYPNTGKSGLDMLGDRVLIGTGGWNGMKDLTVGDFNGDGKDDLVATKAETGELFLYPGTGKKSLEALDDRALIGTGGWNGMKGLFAGDFNGDGKTDLGAVKSETGELFLYPGTGKKSLEALDDRVLIGTGGWNGMNKLAAGDFNKDGKPDLVATKTETGELFLYPGTGKKGLDTLGDRTQIGTGGWNGISDYAAADFTGDGIADLAAVDSDRGETGKLYLYKGNGKGLDSRTEIGTGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGE5</accession>
    <name>A0A2G1XGE5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_21810</name>
        <name evidence="8" type="ORF">CYQ11_08975</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50209">
        <property type="protein sequence ID" value="PHQ50209"/>
        <property type="gene ID" value="BLA24_21810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13007">
        <property type="protein sequence ID" value="PPT13007"/>
        <property type="gene ID" value="CYQ11_08975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20187" checksum="B00F75A81ACDB30C" modified="2018-01-31" version="1">MFSLTVAAVAFGVVFLAELPDKTALAGLMLGTRYRASYVFAGVAAAFLVHVCLAIAAGSVLTLLPHRLVQAVVGVLFLAGATVLLLKKDDDEEEIKKPADQSFWKVSGAGFMLILVAEFGDLTQIMTANLAARYDDPLSVGTGAVLALWAVAGLGIVGGRTLMRYVPLKLITKVAALVMLALAGFSLYEAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGJ3</accession>
    <name>A0A2G1XGJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpdD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22500</name>
        <name evidence="3" type="ORF">CYQ11_08290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50321">
        <property type="protein sequence ID" value="PHQ50321"/>
        <property type="gene ID" value="BLA24_22500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12892">
        <property type="protein sequence ID" value="PPT12892"/>
        <property type="gene ID" value="CYQ11_08290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="106" mass="10647" checksum="8B0259F50BB23208" modified="2018-01-31" version="1">MLYPKVPTNPLPTPVVIPARDIQGDGCPEGSVTPIVCQHTVPPAAPAQRAVQLSAGGTVAAIGLGSVAVLVVGAVLVGMFLAIAITATSLAIVAVIARSMLNDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGM8</accession>
    <name>A0A2G1XGM8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_21130</name>
        <name evidence="8" type="ORF">CYQ11_09655</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50398">
        <property type="protein sequence ID" value="PHQ50398"/>
        <property type="gene ID" value="BLA24_21130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16455">
        <property type="protein sequence ID" value="PPT16455"/>
        <property type="gene ID" value="CYQ11_09655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="26103" checksum="2DF23A9F1C74CA6D" modified="2018-01-31" version="1">MTAPVFLVEEDALTGVFPGTVFPLDGPEGRHAVSVRRLRVGEEIVLTDGAGTGVHGTVTAVEGKDHLEVTVTSVRSEPLPQPRITVVQALPKGDRGELAVETMTETGVDAVVPWTASRCVTQWKGDRGLKSLGKWRATAREAGKQSRRLRFPSVAEAMTTRQVAALLADADFAAVLHEEGSTPLATAELPETGDIVLVVGPEGGVSPEELTAFAEAGAHPYRLGPSVLRTSTAGTAAAALLLGRTGRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGY5</accession>
    <name>A0A2G1XGY5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_16780</name>
        <name evidence="5" type="ORF">CYQ11_16505</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030367299.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50492">
        <property type="protein sequence ID" value="PHQ50492"/>
        <property type="gene ID" value="BLA24_16780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14253">
        <property type="protein sequence ID" value="PPT14253"/>
        <property type="gene ID" value="CYQ11_16505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="113" mass="12380" checksum="21820C1323085EB7" modified="2018-01-31" version="1">MDLSLSTETVGDRTVVRVGGEIDVYTAPKLREQLVELVNDGSYHLVVDMEGVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHTSVEDAVQATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH07</accession>
    <name>A0A2G1XH07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21985</name>
        <name evidence="6" type="ORF">CYQ11_08800</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50419">
        <property type="protein sequence ID" value="PHQ50419"/>
        <property type="gene ID" value="BLA24_21985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16437">
        <property type="protein sequence ID" value="PPT16437"/>
        <property type="gene ID" value="CYQ11_08800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="192" mass="20230" checksum="A830AB05405C4B88" modified="2018-01-31" version="1">MRTALAVLIGREPDLDVSSASWHGALATSRALRPDVCVIDMDSPGASEECGGVRSLAARCGEGDEGGALLALATAGRPGPLRRAYEVGALGYLSKNASPDRLVEGIRHVAKGERYIDETLGYGFLQAAEMPLTRRELSVLSLAAEGASVGEIARSLHLSNGTVRNYMAAITRKTGARNRVDAIRISRGAGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH56</accession>
    <name>A0A2G1XH56_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16985</name>
        <name evidence="4" type="ORF">CYQ11_16295</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50521">
        <property type="protein sequence ID" value="PHQ50521"/>
        <property type="gene ID" value="BLA24_16985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14224">
        <property type="protein sequence ID" value="PPT14224"/>
        <property type="gene ID" value="CYQ11_16295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="13022" checksum="01F08A3CECF5B6B6" modified="2018-01-31" version="1">MMYDQTRAQQPAGRTPDPAGRRGPGPEPLLPSNEQDEIIQRLRHALNTFADAPLEALEEAESAYDEATAQLVNALAKRRRLLRAGWQDQGPGTQSDELRHALRQYREITQRLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH76</accession>
    <name>A0A2G1XH76_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17135</name>
        <name evidence="4" type="ORF">CYQ11_16140</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50541">
        <property type="protein sequence ID" value="PHQ50541"/>
        <property type="gene ID" value="BLA24_17135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14205">
        <property type="protein sequence ID" value="PPT14205"/>
        <property type="gene ID" value="CYQ11_16140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7359" checksum="516842B445B93D71" modified="2018-01-31" version="1">MHAASITELTWRKSSHSGNGTECVEVSDDLPGVVPVRDSKRKNGPSITFTGTAWTSFVEEIHAKRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHD4</accession>
    <name>A0A2G1XHD4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17180</name>
        <name evidence="3" type="ORF">CYQ11_16095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50549">
        <property type="protein sequence ID" value="PHQ50549"/>
        <property type="gene ID" value="BLA24_17180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14197">
        <property type="protein sequence ID" value="PPT14197"/>
        <property type="gene ID" value="CYQ11_16095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="235" mass="26529" checksum="F60CF5A7D249AC76" modified="2018-01-31" version="1">MQPSDRTAAYDGFAETFAQEAAVSAYNAFYDRPTVLALLGDVRGKRVLDAGCGPGLYMTELIARGAEVIGFDQSADMVDRARSRVGSNIQVRRHDLEDRLDWLPNGTIDIALAALVIHYVRNRSTALGELFRVLRPQGRLVLSTSHPTADWLADSGSYFDAREAEETWSCGLRHRYWRQPLQSWIEEFTSAGFAIERLVEHRPHPTMAHEHPADYARLSREPGFIAFRLMKRTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHW3</accession>
    <name>A0A2G1XHW3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18585</name>
        <name evidence="2" type="ORF">CYQ11_14695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50781">
        <property type="protein sequence ID" value="PHQ50781"/>
        <property type="gene ID" value="BLA24_18585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13961">
        <property type="protein sequence ID" value="PPT13961"/>
        <property type="gene ID" value="CYQ11_14695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="10060" checksum="4E956C0C87C144AE" modified="2018-01-31" version="1">MRCVIAHFPFDFVKGEVEQLMTGVEPEAAVGPCAVIDGRTYPVKQVGEVITRQDRRDFTAGEVTRALSRLGFDCLTAPAASSPEPGGWPEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XID7</accession>
    <name>A0A2G1XID7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_14615</name>
        <name evidence="5" type="ORF">CYQ11_13460</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51014">
        <property type="protein sequence ID" value="PHQ51014"/>
        <property type="gene ID" value="BLA24_14615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13764">
        <property type="protein sequence ID" value="PPT13764"/>
        <property type="gene ID" value="CYQ11_13460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="345" mass="37740" checksum="5D57351498B39DDC" modified="2018-01-31" version="1">MRQDPGMEKVRDVRLLPKAHLHLHFTGSMRPSTLLELADKYGVHLPEALSSGQPPRLRATDERGWFRFQRLYDIARSCLRSPEDIRRLVHEAAEEDVRDGSGWLEIQVDPTSYAPRLGGLIPALEIILDAVETASRDTGLGMRVLVAANRMKHPLDARTLARLAVRYADRGVIGFGLSNDERRGLARDFDRAFEIAREGGLLAAPHGGELSGPGSVRDCLDDLHASRVGHGVRAAEDPRLLRKLAERGVTCEVCPTSNVALGVYEKPADVPLRTLYEAGVPIALGADDPLLFGSRLAAQYEVAREHHGFTDAELAELARQSVRGSAAPPDVREKLLAGIGDWLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIH4</accession>
    <name>A0A2G1XIH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14405</name>
        <name evidence="4" type="ORF">CYQ11_13670</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50981">
        <property type="protein sequence ID" value="PHQ50981"/>
        <property type="gene ID" value="BLA24_14405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13797">
        <property type="protein sequence ID" value="PPT13797"/>
        <property type="gene ID" value="CYQ11_13670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="336" mass="35735" checksum="5AE70A2D593A7A8A" modified="2018-01-31" version="1">MTVVGPFGLSVRDQALEADVQAGLAAVEEGLLEATKSGVPFITEAAQHLVQAGGKRFRPLLVMLSAQFGDPYAPGIVPSAVVVELTHLATLYHDDVMDEAEVRRGVDSANARWGNSVAVLTGDFLFSRASRILADLGPEAVRIQAEAFERLVTGQILETAGPRDGRDPIEHYLDVIAGKTGSLIAVSGRYGAMMSGADERVVEILTHYGERLGVAFQLADDVLDIASDSHESGKTPGTDLREGIPTLPVLHLRAAAEATGSPEDLELCAMLEGDLGDDAVLAEVLRRLRVHPALEQARRDTVRFAQEARATLAPLPDCPAKAALEELCDAVVHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIL0</accession>
    <name>A0A2G1XIL0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15035</name>
        <name evidence="3" type="ORF">CYQ11_13035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51088">
        <property type="protein sequence ID" value="PHQ51088"/>
        <property type="gene ID" value="BLA24_15035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13689">
        <property type="protein sequence ID" value="PPT13689"/>
        <property type="gene ID" value="CYQ11_13035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="27698" checksum="19931B5D146EEE4C" modified="2018-01-31" version="1">MTTALITGATAGIGAAFARRLAADGHNLVIVARDEKRLSEQATELHDRHRVEVEVLRADLSQEEGIAAVEARLSDRKNPVDLLVNNAGFGNRGRYLEVPMADELTMLKVHCEAVLRLTSAAAASMRERRRGGVVNVASVAAFVPRGTYGASKAWVVQFTQGAARDLAGSGVRLMALCPGFVRTEFHQRAGMGVDNVPAWMWLDADKLVEAALKDLARGKALSIPDPRYKALTGLMKLAPRRAVSRASASTGRRYGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIN7</accession>
    <name>A0A2G1XIN7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">BLA24_15020</name>
        <name evidence="6" type="ORF">CYQ11_13050</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51085">
        <property type="protein sequence ID" value="PHQ51085"/>
        <property type="gene ID" value="BLA24_15020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13692">
        <property type="protein sequence ID" value="PPT13692"/>
        <property type="gene ID" value="CYQ11_13050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="102" mass="10929" checksum="4144855F85FAD283" modified="2018-01-31" version="1">MTTASSKVAIKPLEDRIVVQPLDAEQTTASGLVIPDTAKEKPQEGAVLAVGPGRFENGERLPLDVKVGDVVLYSKYGGTEVKYNGDEYLVLSARDVLAVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIP7</accession>
    <name>A0A2G1XIP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GuaB3 family IMP dehydrogenase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15070</name>
        <name evidence="4" type="ORF">CYQ11_13000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51095">
        <property type="protein sequence ID" value="PHQ51095"/>
        <property type="gene ID" value="BLA24_15070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13682">
        <property type="protein sequence ID" value="PPT13682"/>
        <property type="gene ID" value="CYQ11_13000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="375" mass="40158" checksum="05A4BD29EE97258F" modified="2018-01-31" version="1">MTEIEIGRGKRGRRAYAFDDIAVVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSVVSPETAIRIGELGGLGVLNLEGLWTRYEDPEPLLAEIAELDEHTATKRMQEIYSAPIKEELIGQRIKEVRDSGVVTAAALSPQRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSGAAEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYMDESGGRYVHVIADGGVGWSGDLPKAVACGADAVMMGSPLARATDAPGRGHHWGMEAVHEDVPRGKRMNLGAVGTTEEILLGPSHTPDGSMNFFGALRRAMATTGYSELKEFQRVEVTVAPSQHDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIP9</accession>
    <name>A0A2G1XIP9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15230</name>
        <name evidence="4" type="ORF">CYQ11_12840</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51124">
        <property type="protein sequence ID" value="PHQ51124"/>
        <property type="gene ID" value="BLA24_15230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13654">
        <property type="protein sequence ID" value="PPT13654"/>
        <property type="gene ID" value="CYQ11_12840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="103" mass="10523" checksum="DEC6377DDB10E740" modified="2018-01-31" version="1">MNFTTTNHTEACGPWEDASATHGTGKRRTLARGAKVLAIAGLVAAVAIIGAGPVVADDHSTTVESFKTPTAAVKVFDDHSTGIFDQANGGSDDHSTIAPLTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIT2</accession>
    <name>A0A2G1XIT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15280</name>
        <name evidence="3" type="ORF">CYQ11_12790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51133">
        <property type="protein sequence ID" value="PHQ51133"/>
        <property type="gene ID" value="BLA24_15280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13645">
        <property type="protein sequence ID" value="PPT13645"/>
        <property type="gene ID" value="CYQ11_12790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304671" evidence="1">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="16299" checksum="E833D055DB0CB5CF" modified="2018-01-31" version="1">MIKRFSVVAAAVVMVVAPLAGVANAAGLPCGGGYSCDNQDPGPVSWDKVDTDDSAKDGGCGSVELRSGKKDGKWYAWARVFVKSGCQGYEGWIDRKGPDGSIEHVLGYFTATDRWGSNFGNMYYWPDGTQVRAGFKHPGEDWSKSGVTKWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ79</accession>
    <name>A0A2G1XJ79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SUKH-3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15935</name>
        <name evidence="2" type="ORF">CYQ11_12140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51241">
        <property type="protein sequence ID" value="PHQ51241"/>
        <property type="gene ID" value="BLA24_15935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13534">
        <property type="protein sequence ID" value="PPT13534"/>
        <property type="gene ID" value="CYQ11_12140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="169" mass="18068" checksum="33451EDBBF69321C" modified="2018-01-31" version="1">MRAFDRTAATRFPVAVDAALREAGWQPGRWDIKAAENWADTLRAHVSPAGHRHTVFPAAVEAWAEFGGLRIIPPGPGRHIAPTPFGIDPLHGLHLARTVADLGRALGTEVCPLGQELDGQALLVIDAHGRVYSLDHTGDWYLGSDIDHAIGTLVTGIRPARLTAGATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ98</accession>
    <name>A0A2G1XJ98_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_16335</name>
        <name evidence="7" type="ORF">CYQ11_11740</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51307">
        <property type="protein sequence ID" value="PHQ51307"/>
        <property type="gene ID" value="BLA24_16335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13467">
        <property type="protein sequence ID" value="PPT13467"/>
        <property type="gene ID" value="CYQ11_11740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="190"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="472"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="593" mass="62716" checksum="F27F056E7D9716E6" modified="2018-01-31" version="1">MDAQGRGRAGGIDPADQWVFDPKTGSYELRLDHAGEPGATADEPSATPSPARVGQQGAAPGARPRPGGKPGAKPGAKPGDGRPVPGQRSGAGGRRAGAKAATGRRRPKPKKSVKKKVLLWTGGTLAFVLVGGSVGAYLLYQHFNNNIDKVDVGINNDAVTKGPVNILVIGTDKRSGSGNTGYGDDGSVGHADTTLLFHVSEDRSNATALSIPRDMITDIPDCPTKQKGGTKNIPGSKGVRFNESLGQEDRDPGCTWRTVEKLTGLKVTHFMMADFNAVKKLSSAVGGVEVCLAKDIDDPKSHLKLSKGRHEIEGEDALAFVRTRHSVGFESDLDRIKLQQQFLSSMIRKMKSGDTLTNPKKLYDLGDAATNSLTVDTGIGSVSKLTSLAKELSKVNLKNITFVTVPVDDNPAEGKNHKTVVLNKAKAEPLFAMVRQDVSLTEVKEKEKKAQEEADAKQAALLQGPRAEPSHVRVKVFNGSGRIGAAQETVAWMQNSKGILRTGNGGNAAGGKKDKTVLQFAPNQADQARRLADDMGLPVDALQQSDAAAAPTAEMTLTLGEDFKGAGIPVSAPKEAPKDIQRVEADDENICAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK3</accession>
    <name>A0A2G1XJK3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13870</name>
        <name evidence="3" type="ORF">CYQ11_01565</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51415">
        <property type="protein sequence ID" value="PHQ51415"/>
        <property type="gene ID" value="BLA24_13870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11756">
        <property type="protein sequence ID" value="PPT11756"/>
        <property type="gene ID" value="CYQ11_01565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="21222" checksum="611C85B06D12F46C" modified="2018-01-31" version="1">MTWPATARYGLEAAPGGLGLVQDLLNTVAAGAHRDLDLLADLGDAQRWADGAAAGWTAVTGQPVPRVVLDADGLEELRAFRGDLHEVTAGGQREEAGPPALVLHCTAASLQLGEDGAVRLEPRGAGWRRLASLVLVAAFEAQLADTRRRLKTCRNPCCRVAFYDRSRNNSGVWHDVRTCGNAANLRAYRARQRAREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJT6</accession>
    <name>A0A2G1XJT6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_13415</name>
        <name evidence="10" type="ORF">CYQ11_01135</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51502">
        <property type="protein sequence ID" value="PHQ51502"/>
        <property type="gene ID" value="BLA24_13415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11684">
        <property type="protein sequence ID" value="PPT11684"/>
        <property type="gene ID" value="CYQ11_01135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="485" mass="48775" checksum="5D87C964AA294EC5" modified="2018-01-31" version="1">MVWVLAVSPLVMVLGMITGLRRPAHWAAVAGAVLAAVLIWWLPDFTLPGDVLTSGAGGAGLLVLNAAAVMLPGVYLSQVLTRREVHRSLREWVRGLPLPGPAKIALVVAGIAPTVEALTGFGVSLLVTVPVLLALAPPPTALRQAMLGMNIMPWGTLGLATVIGAALTGKEVAVLGTATAVTSSLVFPLVTTWAALLARPRRRFRTAAVAAAAGAALSLGLLALNLAGVVQPAGVLAGLLTTGIGLAFCAVRRSRHGAEPAGRLLPPRAVLQAYGLVLGGIALTRAATAAGVPSLTLHAGNAGFALLSSPGLPLLAAALLLDRGRPHGPDARAALARAGRPLLALTGFVTLGRLMADSGMIAELGAAVAGAPSLVTALAAPALGMLSGFLTGSNVGGNAMMMPLQERLAPGGDGLDTWFAALQNSAAGHTVFTSLPMIMLILAVAGDRAKSTDVSEHTLLRFGLGVAAAIYTVLAATAVVVVSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJV2</accession>
    <name>A0A2G1XJV2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13440</name>
        <name evidence="3" type="ORF">CYQ11_01160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51506">
        <property type="protein sequence ID" value="PHQ51506"/>
        <property type="gene ID" value="BLA24_13440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11688">
        <property type="protein sequence ID" value="PPT11688"/>
        <property type="gene ID" value="CYQ11_01160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="608" mass="66041" checksum="ECEFA092A062A821" modified="2018-01-31" version="1">MTAQEQRDALTRPLALHDHIQRRLRDALGELPPRRGHPLPAEREEAETSLPQSGARAAVEEALSPLPDDPAVLLRRFARLGIRSHHCFTIRSVVADLPLPTREQREAARSLGRQLTRTGTTVPAVTTGIALLARLGEPEDVPYLSALGLLRPFPRQAVRALDPLDRPAAALVWLAAGTRCEELLPLVRALWARDRAAIRTELVALPASALFIGAENARRIMEATRLPALLADHPSDTALLARAGRLLVQLGASRDQGNNLLSYPDALTLYEHVVTRAGILPPDLDDHATLLSLALDLRSGPAALLDWPAGRRAALLESLGRLLAQPRWAAVADSTEGGAEQRLRAGWIRRTGRRPFTGPATKGRLRIEVVAGDLADRGPVETRILIDGLPVVPAFFARGPAETPEHLLDGGLLRARPAPHEVRLAEASCTEGCCGALYVTIRRDGEQVVWDDWRRPLTMPGGREPAPEPPAYRFDAAAYDAEVARAEADRSWSWPARTVARLIKAELTARPGLLARWDALQGWISSGFDDPDTTVVTFSYAPGLAAGNADGIPLQFRWVIPDDGGPPERQAAAALRRLAEEDPKTYGTVCGGSRERAEELGFCWPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK07</accession>
    <name>A0A2G1XK07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13210</name>
        <name evidence="2" type="ORF">CYQ11_00930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51469">
        <property type="protein sequence ID" value="PHQ51469"/>
        <property type="gene ID" value="BLA24_13210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11651">
        <property type="protein sequence ID" value="PPT11651"/>
        <property type="gene ID" value="CYQ11_00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="11494" checksum="CD143E8BEFA68B84" modified="2018-01-31" version="1">MYSLPFHAAENHTVTVDVAAELDDPSGNPSLGTIGVGMFQCCDVSDSEVRAQQVGNIGAAGSPVHTHITQQLPNKCSLPTKVGTDFVYYLRLRIASSSQSVHLSYSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK15</accession>
    <name>A0A2G1XK15_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12855</name>
        <name evidence="4" type="ORF">CYQ11_17210</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51583">
        <property type="protein sequence ID" value="PHQ51583"/>
        <property type="gene ID" value="BLA24_12855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14375">
        <property type="protein sequence ID" value="PPT14375"/>
        <property type="gene ID" value="CYQ11_17210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="16133" checksum="7678AA6F26400CA9" modified="2018-01-31" version="1">MVDTDWQSDLRKRGYRLTPQRQLVLEAVDRLEHATPDDILTEVRKTAGGVNISTVYRTLELLEELGLVSHAHLGHGAPTYHLADRHHHIHLVCRDCTAVIEADLSVAADFTEKLRSTFGFETDMKHFAIFGQCAKCSSKAPSGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKC5</accession>
    <name>A0A2G1XKC5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ctaD</name>
        <name evidence="12" type="ORF">BLA24_11340</name>
        <name evidence="13" type="ORF">CYQ11_02575</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51682">
        <property type="protein sequence ID" value="PHQ51682"/>
        <property type="gene ID" value="BLA24_11340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11931">
        <property type="protein sequence ID" value="PPT11931"/>
        <property type="gene ID" value="CYQ11_02575"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="26"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="538"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="575" mass="62544" checksum="A696228D185A4848" modified="2018-01-31" version="1">MPQLEHRPRVQPAGSTENRPTALGGRLLTYLTTTDHKTIGNMYLVTAFGFFLLGGLLAMVMRAELARPGLQIVSADQYNQLVTIHGTVMMLLFATPMFAGFANAVMPLQIGAPDVAFPRLNALTYWLFLFGGLIVVSGFLTPGGAASFGWFAYAPLNSAVRTPGAGGDLWAMGLVVAGLSTTLGSVNFIATIVTLRAPGMTMFRMPVFTWNILFTSILALLAFPVLTAALLALEADRKFGAHVFDAANGGAVLWQHLFWFFGHPEVYIVALPFFGVITEIIPVFSRKPVFGYAGMVGATIAITMLSASVWAHHMFATGAVLLPFFSLMSFLIAVPTGVKFFNWIGTMSRGSISFETPMLWAVGFLVTFLLGGLSGVLIASPPLDFQVTDSYFVVAHLHYVLFGTVVFAMFGGFYFWWPKWTGRMLDERLGKVHFATLFAGFQITFLVQHWLGESGMPRRYADYLAADGFTTLNTVSSIGAFLLGLSTLPFLYNVWHTARHAPKVDRDDPWGFGRSLEWATSCPPPRHNFVTLPQVRSDSPAFDLHHPEAAPQPLPAAPGGAEPGPAAGPREEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKF3</accession>
    <name>A0A2G1XKF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_11385</name>
        <name evidence="8" type="ORF">CYQ11_02620</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the clavaminate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51690">
        <property type="protein sequence ID" value="PHQ51690"/>
        <property type="gene ID" value="BLA24_11385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11939">
        <property type="protein sequence ID" value="PPT11939"/>
        <property type="gene ID" value="CYQ11_02620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014503">
        <property type="entry name" value="Clavaminate_syn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019543">
        <property type="entry name" value="Clavaminate_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="6">
        <location>
            <begin position="227"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR019543-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019543-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="35438" checksum="906960F5719A52DB" modified="2018-01-31" version="1">MSTAAPVRQLDPASVAELRRSAARVLDAFGSSATHPGLLARIAREAAALSPAVRHQCRPVDTAHGLFVLRGLEVDDAGIGPTPASWAVAGDAAAEWDVVLLLLATAMGNPIAWEGQQEGRFVHNIVPTAGREQEQTGASSDVLLSPHTEDAFHPGRAHLLMLCCMRNPDDIATTAASVREVRLTDEDMDCLSRPVLPILPDDAYVEAQGFAGEPPKVPTVWRSEDGPTLRFDPAYTPLGEAPAAYRAAYHRLEGELSRVSRAVSLRPGEVLVVDNDLVVHGRVPFTARYDGTDRWLKRASVRVPGRRSRPEAEALEHGYGQAALEAHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKF5</accession>
    <name>A0A2G1XKF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11510</name>
        <name evidence="2" type="ORF">CYQ11_02745</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51712">
        <property type="protein sequence ID" value="PHQ51712"/>
        <property type="gene ID" value="BLA24_11510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11961">
        <property type="protein sequence ID" value="PPT11961"/>
        <property type="gene ID" value="CYQ11_02745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="21986" checksum="F4626AE394A1BAE0" modified="2018-01-31" version="1">MTGTRLGDDAGAVGRAGTWDTVTAGVVLARLGPRREPPLRFFTPAEEAAAEALMDHLLARSPKDPPIPVLPVIDARLATGESDGWRYADLPEDAEAWRRSLAGLDEDARTRHGGREFARIGYGDRDRLLRYVVQLSGRDWYGMPASHVWSLWTRYACEAYYAHPYAWDEIGFGGPAYPRGYMRLGRGLREPWEDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKP9</accession>
    <name>A0A2G1XKP9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucanase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_12010</name>
        <name evidence="10" type="ORF">CYQ11_03250</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51800">
        <property type="protein sequence ID" value="PHQ51800"/>
        <property type="gene ID" value="BLA24_12010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12046">
        <property type="protein sequence ID" value="PPT12046"/>
        <property type="gene ID" value="CYQ11_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033838707" description="Glucanase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="393" mass="40608" checksum="81BA024D9E1D7D10" modified="2018-01-31" version="1">MPRVRTTRLATGARRGAAVLLCASTVCLPQGAGRAVASGGGDGPDSPFWVQPAGRAARQVRVWEERGREPDAAAVRRIAEQPTAVWMNAEDPRRQVEQIAEEAERAGRIPVLVAYNIPHRDCGQYSSGGARDAAAYREWVARAAAGIGEHRAWVVLEPDAIAQWASGCVPKEAAQERLALLAEAVRTFKAQRGTSVYVDAGNAGWVSDQALLAGALKEAGVGEADGFALNVSNFHTTPVTREYGDRLSDRLGGAHYIVDTSRNGNGPLPPSGVEAHGEEAWCNPPGRALGAPPTTATGDGRIDAFVWIKRPGESDGACRGAPPAGQWWSEYALDLSRAAAAGPPAVPPAPEPAPAPAPPAPVPAAPGPAPAPPPAAAPPAAVPPAAAPPSPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKR4</accession>
    <name>A0A2G1XKR4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAP2 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12155</name>
        <name evidence="5" type="ORF">CYQ11_03395</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51825">
        <property type="protein sequence ID" value="PHQ51825"/>
        <property type="gene ID" value="BLA24_12155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12072">
        <property type="protein sequence ID" value="PPT12072"/>
        <property type="gene ID" value="CYQ11_03395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="87"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="28784" checksum="54346FCD9EE37100" modified="2018-01-31" version="1">MPYVRHWLRNSLLLFALAISLGLVAAHTRLIQPHDLDLDRTIQTNTRTGWLNTLMELVSYCASPVAGVLILGAWCGWLLFARRRPVTAVSTFLVVAVGWNSTQIAKAIVARDRPPRQFSLDPEIGSNSFPSGHTAFTVAAAVATYFLFRNSRHRNTVAVCGVLAVLVVAFSRMYIGAHYPTDTFGSVLVAASAILFVTGVWHAWLLPRLDRLPLLNRFGLDEELAEMEAAQGGYAAGAVPGPHGGRRRAGGAPVSGGRHRKHAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKS2</accession>
    <name>A0A2G1XKS2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11690</name>
        <name evidence="2" type="ORF">CYQ11_02930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51854">
        <property type="protein sequence ID" value="PHQ51854"/>
        <property type="gene ID" value="BLA24_11690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16318">
        <property type="protein sequence ID" value="PPT16318"/>
        <property type="gene ID" value="CYQ11_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="304" mass="32123" checksum="2E7BEE99939EC2B2" modified="2018-01-31" version="1">MPGQDGRSAVVTGANGGIGYATVRALAAAGAEVLLTGRDAERVRAAAVRLTGEVPGARVRPEVLDLADLESVAGFARRLADAGHPVDLLVNNAGVMGVPERRTTEDGFELTFGVNHLGHYALTGRLLPLLLRAPAPRVVTVSAALSRSPIAELSDPQSTHKYRPMAAYAKSKLANVLFARELQRRADVVGAALTSVAVHPGSSLTGLQRYASRPVRTLARLTLERFVGQPVERAAWTPLYAATAPGVVPGGFYGPTGRFEERGAPGPVEPPLLTADSALARGLWELSEDLTGVRYPWPVPRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKS4</accession>
    <name>A0A2G1XKS4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12215</name>
        <name evidence="6" type="ORF">CYQ11_03455</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51835">
        <property type="protein sequence ID" value="PHQ51835"/>
        <property type="gene ID" value="BLA24_12215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12082">
        <property type="protein sequence ID" value="PPT12082"/>
        <property type="gene ID" value="CYQ11_03455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="427" mass="45824" checksum="174F84EA5D9B7F90" modified="2018-01-31" version="1">MTNMTRVEQPDWTLWRARAVDLTLCLVVLTALVAILRSTESTIDWVAPGLQALAAVSLLFRRTAPLPVLVLMLFAAMPMFVEGVLPGTLPEVDRAGVWVPLAAPFACYSVMVYGTELVPAWTFTAVLTLIATRPWSPEVAIIAPGLLLTAVPALAGMYVRAQRRLTDALRDRAERAEREQHLLAEQARAEERANLAVEMHDILTHRVSLMVLHAGALRLSTAEDSTRAAAEELRAAGCQALEELREFVGVLRSPSTPADEEEAGDDEETPDGLPLVGGGDGEEASGEPPARDLAQLVAESEAAGMRIELVESGNRLVASPVIGRTAYRVVQEALANAIKHAPGAPVRVHVRYASDRLHLTIRNEEPEHGPALELSRSGSGVGLTGLRQRVGLVGGELRAGPHPDGGFEVDAELPVFVPAAGDLRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLB9</accession>
    <name>A0A2G1XLB9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10780</name>
        <name evidence="4" type="ORF">CYQ11_00770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51929">
        <property type="protein sequence ID" value="PHQ51929"/>
        <property type="gene ID" value="BLA24_10780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11626">
        <property type="protein sequence ID" value="PPT11626"/>
        <property type="gene ID" value="CYQ11_00770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="25830" checksum="1DF3AF816D5F42C0" modified="2018-01-31" version="1">MSVLSWRRTLSGPPVRLAKVRAVTTPLPHSLRSDARDNRERILAVARTTFAEQGLDVAMREIARRAEVGSATVYRHFPTKEGLVTEAFREQMTACTAVVDVGLADPDPWRGFCLVIEGVCETQARDRGFTAAFASAFPRAIDFAADRERALGKVAELARRAKAAGKLRPDFVLDDLIMVLMANSGIRTTSPTAALTASRRFAALLIQGLRAEPALPPLPPPARLPPAVVSWTVSFGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLC2</accession>
    <name>A0A2G1XLC2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS_TE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000106">
        <property type="protein sequence ID" value="PHQ52016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52016">
        <property type="protein sequence ID" value="PHQ52016"/>
        <property type="gene ID" value="BLA24_10110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="2">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="261" mass="27836" checksum="7118BA1AFB956B8F" modified="2018-01-31" version="1">MDGGTAPAPLFCVHPAAGISWVYSGLLRHLDHDRPVYGLQARGLSDETAAPRSVEEMAEDYLTLVRSVQPHGPYSLLGWSFGGVVAHHLAVRLQEEGEDVAALVLMDGYPSVPTGSPTEADASPGDPGTVREVFESLGHDPAAAAAPDSPLALLARGSWRRDARVHRQRADAGRLHTRRVRRERAPDRGHRREDGRLTAARGVAVPCDGNGACAPGRGAPRRTDPAPPGPAGAGHRRLVRRRTAVGRPTVATRSADRRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLF5</accession>
    <name>A0A2G1XLF5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">BLA24_09100</name>
        <name evidence="7" type="ORF">CYQ11_27710</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52073">
        <property type="protein sequence ID" value="PHQ52073"/>
        <property type="gene ID" value="BLA24_09100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16153">
        <property type="protein sequence ID" value="PPT16153"/>
        <property type="gene ID" value="CYQ11_27710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="318"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="434" mass="47089" checksum="AA4850DBCA07D4AF" modified="2018-01-31" version="1">MPESFAPAELLDLDRRHVWHPYGPMPGRQEPLIVESASGVRLRLAEEAHGSHELVDGMSSWWSAVHGYNHPVLNAAAQEQLGRMSHVMFGGLTHEPAVRLASRLVEITPEGLEHVFLADSGSVSVEVALKMCLQYWRSLGRPEKRRMMTWRGGYHGDTWQPMAVCDPDGGMHQLWSGVLAQQVFADAPPHDYDTDAVPAYSAHLRETIARHAHELAAVIVEPVVQGAGGMRFHDPVYLRVLREACDEHDVLLVFDEIATGFGRTGELFAADHARVTPDVMCLGKALTGGYVTLAATLCTPRVAEGISSGEVPVLAHGPTFMGNPLACAIANASIDLLLSQDWRTEVKRIEAGLRDALADAAPLRGVRDVRTLGAIGVVELDHEVDVAAATRAAVRAGVWLRPFRNLVYVMPPYVTGDEDVARIGAAVCAAAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLN3</accession>
    <name>A0A2G1XLN3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Long-chain-fatty-acyl-CoA reductase</fullName>
            <ecNumber evidence="5">1.2.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_09550</name>
        <name evidence="10" type="ORF">CYQ11_28160</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.50"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid reduction for biolumincescence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LuxC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.50" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52152">
        <property type="protein sequence ID" value="PHQ52152"/>
        <property type="gene ID" value="BLA24_09550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16233">
        <property type="protein sequence ID" value="PPT16233"/>
        <property type="gene ID" value="CYQ11_28160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00569"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050062">
        <property type="term" value="F:long-chain-fatty-acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008670">
        <property type="entry name" value="CoA_reduct_LuxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05893">
        <property type="entry name" value="LuxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0455">Luminescence</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="8">
        <location>
            <begin position="489"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="834" mass="90172" checksum="4D7D2FBC7BF22833" modified="2018-01-31" version="1">MTTPTVQHHYWQGAFIDDAEAERRLADLPAAVEAALAAPLETETVLAACERLAAVLADPAHPTHLRLAGHLPEGEDGALLTELAAFLSRAELTRKLRRELGGTAPQRLNRPDAKETVYEAWAPVGMVAHIAPGNAATVAPLSLVEGLLAGNVNVLKTSGGDTLLAQHLLAELAALDPTGAVAERVIVLRFSSSRQDWLSLMCAAADAVAVWGGEAAVEGVAAHVPPGCRLVEWGHKISFAYLTRDAWQDPAALTALARDVCLHEQQACSSPQVVYLDTEDRDEVLAFAERFAAVLADVPPAERADALDAAEEAELTTTELIARLEEHLDLTRVITAPDGSWRVMADTRPALTASPLHRSVWVKPLPRKSVLRTLRPMRRYLQTAGIAGSRGDIAELSRLALAAGATRVTPLGEMLGSYPGEPHDGVYALQRYSRRVAVRADERFATTACLDDLTRPASFPPPAGPLLDKAAVQELNDSVDRRDAELYFRSGGSTGTPALSLFTYDDYDTQMHAAARGLLAAGYDPARDRTANLFYCGGMYGGFISFFSILERLGGVQMPMAAGTDHRATAEALVAYEVDTLFGMPSYLWQLLHEQADLLRSYGGIRKIFYGGEHFTAEQRRTLTETFGIEVIRSITYGSTDLGPLGYQCTESAGGVHHLHADLHTLEILDVDADRPVPPGETGRLVFTTHARRGQNLGRYVIGDLGRALPGPCACGSRAPRFELLGRLGDVMRVATYFLNYRRFVAIAEETCGYVGETQVLLAADGSRERLTVRVERTDTTPERLRAALLAGYPELRSAVDERLLDLAVETADPAGFARTAASGKLRAVVDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLX6</accession>
    <name>A0A2G1XLX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09510</name>
        <name evidence="4" type="ORF">CYQ11_28120</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52181">
        <property type="protein sequence ID" value="PHQ52181"/>
        <property type="gene ID" value="BLA24_09510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16847">
        <property type="protein sequence ID" value="PPT16847"/>
        <property type="gene ID" value="CYQ11_28120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="90"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="244" mass="26557" checksum="F589CD38E61E7C80" modified="2018-01-31" version="1">MNGPEIQLTFAPELRLFLSADRRRPGAAVITDGVSTLGHVVESLGVPLTEVGRLCVDGRPVPVSHVPAAGESVEVEAVTRPQEVPGAPLRFLLDVHLGTLARRLRLLGVDAAYESEDLGDPALAALSAAEQRVLLSRDRGLLRRREIWAGGYVYSDRPDEQLRDVLSRFAPRLAPWSRCTACNGPLQDADKDAVREHLEHGTRRTYDVFAQCAACGRVYWRGAHHARLQAIVESAVSEFGAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMM0</accession>
    <name>A0A2G1XMM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06700</name>
        <name evidence="3" type="ORF">CYQ11_26850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52466">
        <property type="protein sequence ID" value="PHQ52466"/>
        <property type="gene ID" value="BLA24_06700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15999">
        <property type="protein sequence ID" value="PPT15999"/>
        <property type="gene ID" value="CYQ11_26850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046198">
        <property type="entry name" value="DUF6230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19741">
        <property type="entry name" value="DUF6230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758886" evidence="1">
        <location>
            <begin position="29"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="191" mass="19754" checksum="765B98D5999C34AC" modified="2018-01-31" version="1">MKGTRRKGGRRVSRRRLAAASFAGLALAGGLLMATANGVLAVSAAGSGGAFKLTGERLEGDAFRERTDVIVERDGTRHPVAVVSAERAWVKGLCASLLVPTPFGPLTLRGSAGRTRPVLATGIVINTDRVRGGDTSFSDLRVGLLPEGGVGAATGHAAVDRPEFTSWLATAGTFRMSDVDVGVEAGRHECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMN2</accession>
    <name>A0A2G1XMN2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C(20)-methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Precorrin-3B C(17)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_06750</name>
        <name evidence="9" type="ORF">CYQ11_26900</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52476">
        <property type="protein sequence ID" value="PHQ52476"/>
        <property type="gene ID" value="BLA24_06750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16009">
        <property type="protein sequence ID" value="PPT16009"/>
        <property type="gene ID" value="CYQ11_26900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="255"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="502" mass="54028" checksum="0E593C546AC4F3B5" modified="2018-01-31" version="1">MSEQSSTTGRLYGVGLGPGDPSLMTVRAVEVIASADVVAYHSARHGRSIARSIAERHLRPDHVEERLVYPVTTETTDHPGGYRGAMEEFYEEAAARLAAHLDAGRSVAVLAEGDPLFYSSYMHMHKRLAHRYATEVVPGVTSVSAAAARLGEPLVEGEEVLTILPGTLPEEELTARLAATDSAVVMKLGRTFPAVRGALERSGRLPEARYVERATMSGERTGRLADVDPASVPYFSVAVLPSRVDAAPATTRGEVVVVGLGPAGPLWLTPEARGELAAAEDVVGYSTYVDRVPARPGQRRHASDNKVESERAEFALDLARQGRRVAVVSSGDPGVFAMATAVLEVASEGPYRDIPVRVVPGMTAAHAAAARAGAPLGHDYAVVSLSDRLKPWEVIAERLRSAAAADLVLALYNPGSRSRLWQVGKARELLLEHRTPDTPVVVARDVGGPQEHVRVVRLGELDPSEVDMRTLLIVGSTQTRAVRRGEDGTEEIVWTPRRYPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMQ5</accession>
    <name>A0A2G1XMQ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07105</name>
        <name evidence="4" type="ORF">CYQ11_27260</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52535">
        <property type="protein sequence ID" value="PHQ52535"/>
        <property type="gene ID" value="BLA24_07105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16072">
        <property type="protein sequence ID" value="PPT16072"/>
        <property type="gene ID" value="CYQ11_27260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758515" evidence="2">
        <location>
            <begin position="28"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="432" mass="46729" checksum="9432DE5FA8093796" modified="2018-01-31" version="1">MPISRPRVAVASLLVLPLTLTACGSGGDGGGGGSSADGKPEGTITFQTWNLRAKFKDYFDGLVKDFERQNPGVKVKWLDQPAEHYADKLSAEAGGGTLPDVVNVSPDLSFPLAKAGMLTNLDKEKAAARFKGEYTPEAWQGNTLPGLDGSYAFPWYLNTGPLFYNKALFRSSGLDPEKPPKSYEELFATAMTMAEKSGGRTATLANTPSIEDFGRYGVQLMNHDATRFTYNEPKGVELLSKYKELYDRGGLDPQALTNSAEKSGQKFLEQKVAMNPGGAHDLETFKKNAPSLYRELGITDAPNNTGKPNMYVMGLAVNEHSAHKAAAVAFAHFVTAKENQEAFAHKVAVFPSTRGSLDDPYWTADDGTDEGRVRVASAKMLKGAVNYTPVVMSDEMKTVLKNEVAKALQGRKSPRQALDDAAAQSDKLLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMS2</accession>
    <name>A0A2G1XMS2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dodecin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06920</name>
        <name evidence="2" type="ORF">CYQ11_27070</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52503">
        <property type="protein sequence ID" value="PHQ52503"/>
        <property type="gene ID" value="BLA24_06920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16038">
        <property type="protein sequence ID" value="PPT16038"/>
        <property type="gene ID" value="CYQ11_27070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="70" mass="7805" checksum="AB2AC7F1CCD10368" modified="2018-01-31" version="1">MSNHTYRVTEIVGSSDEGVDAAIRNGISRAAQTLRELDWFEVTQIRGHLENGSIAHYQVGMKVGFRLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT9</accession>
    <name>A0A2G1XMT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitine dehydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07290</name>
        <name evidence="3" type="ORF">CYQ11_27445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52565">
        <property type="protein sequence ID" value="PHQ52565"/>
        <property type="gene ID" value="BLA24_07290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16103">
        <property type="protein sequence ID" value="PPT16103"/>
        <property type="gene ID" value="CYQ11_27445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="406" mass="43222" checksum="92371C920106F5D9" modified="2018-01-31" version="1">MQAPLSGVTVVALEQAVAAPFATRQLADLGARVIKVERPGGGDFARDYDGRVKGLSAYFVWVNRGKESVVLDLKTPADRSLLDRLIDRADVFVQNLGPGAAERLGLGCDVLRARDPRLITCDLSGYGTAGPYRDEKAYDLLVQCETGLVSLTGSADSMARPGISVADIAGGMYAFSGILTALYERERTGTGTALSVALFDALAEWMGHPYFAEAYGGPPLARSGARHPSISPYGPYRCGDGTRVFLSVQNDREWVALCERVLLRPALVRDPRFADNPLRHAHDGELTAVLEECFAAHTADGVLALLGEAGIAHARLRTVAEFAAHPQLAARDRWRDFASPAGPLRGLLPPVVVAGREAAMGAVPALGEHTEAIRAEFTRPRAPEGDPAGGTHAVRTRQEGLGGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMW9</accession>
    <name>A0A2G1XMW9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor SigJ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_07495</name>
        <name evidence="9" type="ORF">CYQ11_27645</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52604">
        <property type="protein sequence ID" value="PHQ52604"/>
        <property type="gene ID" value="BLA24_07495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16141">
        <property type="protein sequence ID" value="PPT16141"/>
        <property type="gene ID" value="CYQ11_27645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="35096" checksum="71CDF60BB072822D" modified="2018-01-31" version="1">MPAGRDRPPVARDESGFTWTTPAGLGWDGAVTASDAVLDAFEEHRSTLTGVAYRMLGRFADAEDVVQEAWLRWSQAGREDVRDPRGYLVRVTTRLAVDRLRQVTARREAYVGPWLPEPVFTDLGEAVPDTAERAVLADSVSLAVLVVLESLSPLERAVFVLREAFGFPYQEIAATLDRSEAAVRQLAGRARRHVEERRPRFDVDPVSRRDLTERFLAAAAGGSIEDLLALLAPDVRLVSDGGGKAKAPLRVIESADKVGRFLLAVSGAFPDAQALVTEVNGGPALLLLVAGRPDTLLSLHVSEGRVAEVYLLRNPDKMLGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XND3</accession>
    <name>A0A2G1XND3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05725</name>
        <name evidence="3" type="ORF">CYQ11_02200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52764">
        <property type="protein sequence ID" value="PHQ52764"/>
        <property type="gene ID" value="BLA24_05725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11865">
        <property type="protein sequence ID" value="PPT11865"/>
        <property type="gene ID" value="CYQ11_02200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304866" evidence="1">
        <location>
            <begin position="38"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="192" mass="20149" checksum="0330C285789FAECC" modified="2018-01-31" version="1">MPRARHALAAATALTLCASAALTLGATTPATAGPAHVAGKAADEPSLTGFGKLKREPGDNPYFAVDARGFGDKAHGDFYVSHHVGKEWGGHFKGRVDCLLTGGPVAVVTGVVTESEFKGAPGMPDVGDLKGKRFGFTVMDDGKHDRVGYSWAMDGMPKNSVGKCVSSAPFETLEKGDYSVHHWMPPRQSAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNE2</accession>
    <name>A0A2G1XNE2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05625</name>
        <name evidence="4" type="ORF">CYQ11_02085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52748">
        <property type="protein sequence ID" value="PHQ52748"/>
        <property type="gene ID" value="BLA24_05625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11845">
        <property type="protein sequence ID" value="PPT11845"/>
        <property type="gene ID" value="CYQ11_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="153"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="449" mass="48800" checksum="82DB949299AF9E59" modified="2018-01-31" version="1">MTVRPRPPAPAGGRHAYGCICPAIRNQEPTVTLVPGEGDWIFSVAAPPVLDAIRGPHRPVPLALTPGTAVALDGGVASDPRRPDDRQGAGMPVPPQRDPSRAREVITRWLTDRFPADGTPTVGSLSTPAETGFSGETLLCDATWDHRGRSLVRPLAVRVAPAGHRLLPESPWHRQVRLQELLAGTDVPVARIHGSEPSGDLLGAPFVVMERIEGRVPGDIPSYHRSGWLAELPPADRAQVWNGGLRVMARLHRLDPDALDLSFLDDPAHGAAGIGRQFGECLAHLEFYGVQDDPVVARAADWLRKHRPEEPDPPRLLWGDARIGNIIYSGHTPVALLDWEMATLGAPESDLAWYLFTDRYLSEGLGLPRLPGLPSRQETVAAYASLLGRPLRDLTFYEVFSAFRFSLITSRVTRLMTGTGIHWPGGRTPYVQSAALLVRALDEADEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNG3</accession>
    <name>A0A2G1XNG3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05865</name>
        <name evidence="2" type="ORF">CYQ11_02340</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52787">
        <property type="protein sequence ID" value="PHQ52787"/>
        <property type="gene ID" value="BLA24_05865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11889">
        <property type="protein sequence ID" value="PPT11889"/>
        <property type="gene ID" value="CYQ11_02340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="352" mass="39281" checksum="B6C6712D3EA21665" modified="2018-01-31" version="1">MTAQAETVAELRHRYRRDLAPGVERFFEPRRVTCPWCSSDRLRERLRTTDLIQHKPGTFVVEECRACGHRFQNPRLTPEGLDFYYRDFYDGLGARTADLIFRSPGSEARHRAVARSVAPFTDPRRWLDVGTGHGHFPKVAKEVFPRTAFDGLDLGEGVETAAREGRIEEAHRGSFTELADGMAGHYDVVSMHHYLEHTPDPRRQLTAARTALRPGGLLLVEVPNPESAYATLLGRWWLPWFQPQHLHLIPSRNLRGAVCELGFTVVTTERGAAHQPVDLAAAVALRMFDLMPRGDAPWHPGPPTALARSLRTAVLAAALPAVAAAYGLDRLVAPVARRAGLSNAYRLVARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH1</accession>
    <name>A0A2G1XNH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type III polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_05735</name>
        <name evidence="6" type="ORF">CYQ11_02210</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52766">
        <property type="protein sequence ID" value="PHQ52766"/>
        <property type="gene ID" value="BLA24_05735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11867">
        <property type="protein sequence ID" value="PPT11867"/>
        <property type="gene ID" value="CYQ11_02210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="70"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="229"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="38378" checksum="C639B6F88B53ECAC" modified="2018-01-31" version="1">MTTRIAAVHGTLAPHRHAQQEITDVIAGLCLPAGADRGVLDRLHRSVGVRARHLVVPLDRYARLNGFGAANDVFVEAATELGARALRGALRGAGLGPEDVDMLMFASVTGVATPSIDARIVGRLGLRPDVKRLPVFGLGCVAGAAGIARLHDYLRGWPEHVAVLVSVELCTLTFQRGDASTANLVATGLFGDGAAAVVACGARWRGPADPAPATPATPAASGPWVVATRSHLYPGTERTMGWDVGDSGFQVVLDRSVPDVVRRHLADDVHGFLHEHGLKPQDVTAWVCHPGGPRVLDTVADVLDLPDGALDVTWRSLAEVGNLSSASVLHVLRDTLAERPPPPGTPGLLLAMGPGFCSELVLLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNK4</accession>
    <name>A0A2G1XNK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_04455</name>
        <name evidence="3" type="ORF">BLA24_14020</name>
        <name evidence="5" type="ORF">CYQ11_01715</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51443">
        <property type="protein sequence ID" value="PHQ51443"/>
        <property type="gene ID" value="BLA24_14020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52835">
        <property type="protein sequence ID" value="PHQ52835"/>
        <property type="gene ID" value="BLA24_04455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11784">
        <property type="protein sequence ID" value="PPT11784"/>
        <property type="gene ID" value="CYQ11_01715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="84" mass="9237" checksum="A294B9545B69AE87" modified="2018-01-31" version="1">MSDTLDREAVETYVTDALVELGVDRSAIVPDASIDDLEVDSLDMVELSQSLRKDLRIPVKPKDFDEVETLGQLLKVCCEKAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNQ1</accession>
    <name>A0A2G1XNQ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04680</name>
        <name evidence="3" type="ORF">CYQ11_28850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52867">
        <property type="protein sequence ID" value="PHQ52867"/>
        <property type="gene ID" value="BLA24_04680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11473">
        <property type="protein sequence ID" value="PPT11473"/>
        <property type="gene ID" value="CYQ11_28850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="403" mass="41585" checksum="BB33989812DC1E9D" modified="2018-01-31" version="1">MTVHHVAVVGAGMAAARFAQQFSARTGGAARLTLYGAEPHAPYNRTLLADVLTGRYDEHAVGLPYGPDAEVRTGTRVTAVDPATRTLTLDDGSAARYDTLVLATGAAPVPPDLPGPHGALPEGVHVLRTLADCRGLADDARRVTRAVVVGGGVLGVSAARALAALGLRTAIVHRAPHLMERHLDPAPAGALRRHLEALGIAVHTGATARALHGTGRVTAVELPGGRHLRAGLVVFACGVRPRTGLARAAGLTVRRGVVVDDHLATSAPGVHAVGDCAEHRGIVHGLADPAWQQADVLAARLSGADPRARYTGTRPHTRLTAGSLQLAAFGDPGTAAAGPRDVLSLADATRGTYKQLVLDGDRLASAVLLGDLTTAGDLIRAWRHDEPLPADPSRLLVPEGAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNV7</accession>
    <name>A0A2G1XNV7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">hypA</name>
        <name evidence="5" type="ORF">BLA24_05050</name>
        <name evidence="6" type="ORF">CYQ11_28480</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52922">
        <property type="protein sequence ID" value="PHQ52922"/>
        <property type="gene ID" value="BLA24_05050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11417">
        <property type="protein sequence ID" value="PPT11417"/>
        <property type="gene ID" value="CYQ11_28480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020538">
        <property type="entry name" value="Hydgase_Ni_incorp_HypA/HybF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00100">
        <property type="entry name" value="hypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01249">
        <property type="entry name" value="HYPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="119" mass="12782" checksum="4A2A6409CB346307" modified="2018-01-31" version="1">MHELSIAAAIVERAAETAGRHGAARVAAVRVRVGELAGVVPDALRFSFEVAREGTVLETARLLIEEVPGRARCAHCAEHFAVGMPPLLWCPRCDRPAEDLTGGRELEITGIELEEEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNY6</accession>
    <name>A0A2G1XNY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04690</name>
        <name evidence="4" type="ORF">CYQ11_28840</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52869">
        <property type="protein sequence ID" value="PHQ52869"/>
        <property type="gene ID" value="BLA24_04690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11471">
        <property type="protein sequence ID" value="PPT11471"/>
        <property type="gene ID" value="CYQ11_28840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="288"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="288"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="40874" checksum="8CE57DC45676B6F3" modified="2018-01-31" version="1">MCTASTTPAPVREGPGPLTGFTIGLTAARRREELVALLERRGARVVEAPTVRIVPLEDDDALRRATRSCLDAPLDYVVATTGVGWRGWMSAAEGWGDGGALLAACRQATVVSRGPKATGAVRASGLHEAFSPGTEASQEVLAWLLGRDLRGRRVAVQEHGAPMEAFAAALRERGAEVITAPVYRWSPPRDAQAVRRLVEAAVHQEVQALAFTSAVAAVALLETAAAAGRREELLAALRTGVTAACVGDLCAQPLLEAGVPVHRPPRARLGALVRTLTEVLPRHGRWGRRPLRSGPHPLVLQGNALLGDGDPVWLPPLPAAVLRALAERPGHVLSRGELLSRAWPGDHADEHAVEMAVTRLRKVLGPHAGLVRTVPKRGYRLADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPB0</accession>
    <name>A0A2G1XPB0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pyk</name>
        <name evidence="17" type="ORF">BLA24_03990</name>
        <name evidence="18" type="ORF">CYQ11_07325</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53050">
        <property type="protein sequence ID" value="PHQ53050"/>
        <property type="gene ID" value="BLA24_03990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12720">
        <property type="protein sequence ID" value="PPT12720"/>
        <property type="gene ID" value="CYQ11_07325"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ53050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT12720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="477" mass="51777" checksum="BEB5DC559224B7D7" modified="2018-01-31" version="1">MRRAKIVCTLGPATDSYEQIKALVEAGMDVARFNLSHGTYVEHETRYQRVRKASDEIGRSVGVLADLQGPKIRLGRFREGPVLLERGDEFTITVEDVEGDRHSCGTTYPGLAHDVSRGERILVDDGRVTLEVIDVHGPRVRTMVIEGGMVSDHKGLNLPGVAVSVPALSAKDVEDLRWAIRTGADIIALSFVRTGHDIDDVHRVMDEEGRRLPVIAKIEKPQAVQNLDDIVAAFDGIMVARGDLGVEMPLETVPIVQKRAIKLAKRNAKPVIVATQMLDSMIDASRPTRAEASDVANAVIDGTDAVMLSGETSVGKYPVETVKTMGRIVAAAEEDVLAKGLPPLTERSKPRTQGGSVARAAAEMGDFLGAKFLVAFTQSGDTVRRLSRYRSPIPLLAFTPEPATRSQLNLTWGVETFLGPMVQTTDEMVEQVDEHLLRIGRCRKGDMVIITAGSPPGTPGTTNLVRVHHIGEDDSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPE1</accession>
    <name>A0A2G1XPE1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000052">
        <property type="protein sequence ID" value="PHQ53083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53083">
        <property type="protein sequence ID" value="PHQ53083"/>
        <property type="gene ID" value="BLA24_03770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="267" mass="27727" checksum="093BD6E335FB042D" modified="2018-01-31" version="1">MDVAGPPLHRGRGPGRPEVRGLGRLPWELLGGLLQGVPSVVLGSDEVLDPALFAAAVAREAITHLYVTPQLLAGLLEESAALAGGHQPVLVTSGADALPVSVVRRFREVWPAATLLNLYGMTETASNVGAYDTAALPDDAERVPVGRAVAGAVLSVRDRLGRRLPAGAPGEVWVSGPPLAWATWAATTGTGSPRTPPGPATTAPATAAASCRTAPWRSPDAPTTRSRSAATGWNWKRSSPPCARRRASPTPGRTPTGRRARHASWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPJ1</accession>
    <name>A0A2G1XPJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02095</name>
        <name evidence="3" type="ORF">CYQ11_04460</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53158">
        <property type="protein sequence ID" value="PHQ53158"/>
        <property type="gene ID" value="BLA24_02095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12248">
        <property type="protein sequence ID" value="PPT12248"/>
        <property type="gene ID" value="CYQ11_04460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021459">
        <property type="entry name" value="GH101-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11308">
        <property type="entry name" value="Glyco_hydro_129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758541" evidence="1">
        <location>
            <begin position="33"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="664" mass="70985" checksum="8FC87B4AEBA35C53" modified="2018-01-31" version="1">MHFTNSSRTARAAAVALAVTLPCVTLVTGAADATSPPAQAVRVHDHLVDVPVAGGTATIDTTTLRVTARTASGSVELSAPAAGAPGTPGRVTTTADGARWTYGNTGLTVTARAEKGRLLVSVRSTGSADHTLKWPVTGGDPAASALQLPRGEGLSIPVGDTFWNSPEAGLAGSSTGMDSGLTLPLWGYTTGRTGVSYLVPTDIGTTLDIASEKGRLRTTAAHTFSRGDGTTDYTVAFSLTDGSPVAPAVDYRAWMKEHGQLGSLKRKIEAVPANKKLLGAFHAYVWGKARTPEGIRKLRALGVDRMWIGYDSGPNPMNAAAVSAAKEAGYLVGPYDSFANGQDPATSDTPTSTWPDKVYPDFCVQRADKTPEPGFHDRGCYLSTEAFEKAEPTRHYLADRTRQMTANGADSYFLDVDAAGELWRDHSPSHPQTKAQDRANRLARMKRLADGDKLALGSEAAGAWSNQVLSYDHGSGTPVHDGLWKAERDKQKWGGYAPEKAPDTFFKPAELPADVAKAMYDPTYRVPLFETALHDSLVNVERWELSYDKLPRQKTDRALLAMLYNTPLNFVISGDSLDKQGGELAALQKYFAPLHQAAGTEPMTGFRTLTPDRTVQRTSFGDGTLTVTANFGPKTYDGLPGGCVDARLKGDKEARRLCPADVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT1</accession>
    <name>A0A2G1XPT1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ORF">BLA24_02740</name>
        <name evidence="7" type="ORF">CYQ11_05035</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53248">
        <property type="protein sequence ID" value="PHQ53248"/>
        <property type="gene ID" value="BLA24_02740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12341">
        <property type="protein sequence ID" value="PPT12341"/>
        <property type="gene ID" value="CYQ11_05035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="189" mass="20519" checksum="68D83C1B44CDD810" modified="2018-01-31" version="1">MDAIPSARPVLEAPDIARVLTRIAHEIVERAKGADDVVLLGIPTRGVFLAHRLAAKLEDITGGKTPVGSLDITMYRDDLRLRPARALARTEIPGEGIDGRLVILVDDVLFSGRTIRAALDAMNDIGRPRAVQLAVLVDRGHRELPIRADYVGKNLPTSLRETVKVQLTEEDGRDSVLLGVRETAPADAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT3</accession>
    <name>A0A2G1XPT3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02100</name>
        <name evidence="3" type="ORF">CYQ11_04465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53159">
        <property type="protein sequence ID" value="PHQ53159"/>
        <property type="gene ID" value="BLA24_02100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12249">
        <property type="protein sequence ID" value="PPT12249"/>
        <property type="gene ID" value="CYQ11_04465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="138" mass="14501" checksum="0CA837EA4B3A5E7C" modified="2018-01-31" version="1">MPEQTPETDEPAHDPEVLQLAAKVFDLARHGDTDTLAAYVDAGVPANLTNDKGDSLVMLAAYHGHDRAVLALLERGADPNRPNDRGQTPLAGAVFKGESEVVRVLVEHGADPAAGVPSALDTAAMFARQDLLDLLQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPU4</accession>
    <name>A0A2G1XPU4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">BLA24_02730</name>
        <name evidence="8" type="ORF">CYQ11_05025</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53246">
        <property type="protein sequence ID" value="PHQ53246"/>
        <property type="gene ID" value="BLA24_02730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12339">
        <property type="protein sequence ID" value="PPT12339"/>
        <property type="gene ID" value="CYQ11_05025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="47"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="428" mass="45046" checksum="BAEB0AACB85CA569" modified="2018-01-31" version="1">MTKILIRGAKVLGGEPQDVLIDGETVAAVGTGLDAGDATVIEAAGKILLPGLVDLHTHLREPGREDSETVLTGTRAAASGGYTAVFAMANTFPVADTAGVVEQVWRLGKESGYCDVQPIGAVTVGLEGKQLSELGAMHDSAAGVTVFSDDGKCVDDAVIMRRALEYVKAFGGVIAQHAQEPRLTEGAQMNEGVVSAELGLGGWPAVAEESIIARDVLLAEHVGSRVHICHLSTAGSVEIVRWAKSRGIDVTAEVTPHHLLLTDELVRSYNPVYKVNPPLRTERDVMALREALADGTIDIVATDHAPHPHEDKDCEWAAAAMGMVGLETALSVVQQTMVETGLLDWAGVAERMSFKPASIGGLAGHGRPIAVGEPANLTLLDSAYRGVVDPAGFASRSRNTPYEGRELPGRVTHTFLRGRATVVDGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ09</accession>
    <name>A0A2G1XQ09_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_03070</name>
        <name evidence="11" type="ORF">CYQ11_05370</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53300">
        <property type="protein sequence ID" value="PHQ53300"/>
        <property type="gene ID" value="BLA24_03070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12397">
        <property type="protein sequence ID" value="PPT12397"/>
        <property type="gene ID" value="CYQ11_05370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="420" mass="44498" checksum="1976F05C41AB74FB" modified="2018-01-31" version="1">MTMMRLRREDPRVVGSFRLHRRLGAGGMGVVYLGSDRRGQRVALKVIRPDLAEDQEFRSRFAREVSAARRIRGGCTARLVAADLEADRPWFATQYVPGPSLHDKVNEEGPLSAAQTASIGAALAEGLLAVHDAGVVHRDLKPSNILLSPKGPRIIDFGIAWSTGASTLTHVGTAVGSPGFLAPEQVRGAAVTPATDVFALGATLAYASTADSPFGQGSSEVMLYRVVHEEPQLMGVPDALAPLIHACLAKDPEERPSTLQLSLRLKEIAAREAHGLSEGRPPSPRREPDRPPARRAAEYERQRTERQPGGSPTPRPHAPLRSPEAHRAPERRPAPPRARRGGSGSRAGARTGPGARRPGPDRKLLRQRLIVFVVVTLLVALGIAAAQGCQGPAHSMDRLPSPPVVSGGAAAGPGGSSADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ7</accession>
    <name>A0A2G1XQJ7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="9" type="ORF">BLA24_00875</name>
        <name evidence="10" type="ORF">CYQ11_07885</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53517">
        <property type="protein sequence ID" value="PHQ53517"/>
        <property type="gene ID" value="BLA24_00875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12822">
        <property type="protein sequence ID" value="PPT12822"/>
        <property type="gene ID" value="CYQ11_07885"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="8">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="28035" checksum="CDB435A09CB6CBFD" modified="2018-01-31" version="1">MADDLLTIAETPFTSRLIMGTGGAPSLDVLERALLASGTELTTVAMRRLDATVRGSVLSVLEKHGIRVLPNTAGCFTAGEAVLTARLAREALGTDWVKLEVIADERTLLPDPIELLDAAEILVDDGFTVLPYTNDDPVLARKLEDVGCAAIMPLGAPIGSGLGIRNPHNFQLITERAGVPVILDAGAGTASDAALAMELGCAAVMLASAVTRAQEPVLMAEAMRHAVEAGRLAHRAGRIPRRHFAEASSPVEGRAALDPERPAFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9C6</accession>
    <name>A0A2G1X9C6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30435</name>
        <name evidence="2" type="ORF">CYQ11_23530</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47833">
        <property type="protein sequence ID" value="PHQ47833"/>
        <property type="gene ID" value="BLA24_30435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15458">
        <property type="protein sequence ID" value="PPT15458"/>
        <property type="gene ID" value="CYQ11_23530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="297" mass="31610" checksum="42FE41EDC7722EC3" modified="2018-01-31" version="1">MNADRFHRALASLRGLAVGDALGSQFFVPANYPALKRRELPPAPWRWTDDTEMACSVLAVLAEHGRIDQDALARSFAERHDFDRGYGPAVGRMLRLIREGGDWRELAAALFKGQGSWGNGAAMRIAPLGAWYADDPEQATHQAEISAYTTHQHREAVAGSMAVAAAAAIAASPARAVTPEELLDGVIALVPRSAVQAGLRRARDMLDYGDATTVAAVLGCGRRTSAHDTVPFALWAAARHLGSFEEAFWTTARAGGDVDTTSAIAGGVVAAAERGAPPESWLRHTEALPGWLPGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9E3</accession>
    <name>A0A2G1X9E3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_30510</name>
        <name evidence="7" type="ORF">CYQ11_23605</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47847">
        <property type="protein sequence ID" value="PHQ47847"/>
        <property type="gene ID" value="BLA24_30510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15472">
        <property type="protein sequence ID" value="PPT15472"/>
        <property type="gene ID" value="CYQ11_23605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="182"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ47847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="26350" checksum="A31B3A584A337A15" modified="2018-01-31" version="1">MAGGGPSGGSGAGGPGSGGDLGGGGGAERRAARVVVVDDQTVVREGIVMLLGLLPGIEVVGSAGDGLEAVRVVAEQAPDVVLMDLRMPRCDGVEATRRIRSEFPGTQVVVLTTYADDDSLFPALQAGARGYLTKDAGGDEIVRAVNHVMSGEAGLSPKVQLRLLERLSTPGAELSAAGPAAPRELPDGLTVREAEVLSLVAEGLSNGEIARRLQVSTATVKTHINNLFAKTGVRDRAQAVRYAFRQGIAQPPGTPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9G3</accession>
    <name>A0A2G1X9G3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30625</name>
        <name evidence="4" type="ORF">CYQ11_23720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47865">
        <property type="protein sequence ID" value="PHQ47865"/>
        <property type="gene ID" value="BLA24_30625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15490">
        <property type="protein sequence ID" value="PPT15490"/>
        <property type="gene ID" value="CYQ11_23720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="353" mass="35199" checksum="8300518219AB8B82" modified="2018-01-31" version="1">MDDKGESDAKTKGKRLDLSVAQVAGSALAAVVAALLAGKLGVYGTVIGAGVVSVVATTGGTLFHHLFKRTGEQIREVTVQGEPRLRQVPLREAGRAVGRARAGGAAAAASPDAAARGHRAAPDRARLDETRMLPTAEDATRRLHQASQPGASPAQSEAHAGAYTGAHDHARFDAYPGDYSEEYSHGTTHGTRLRGWKRPLLAAGAVFVLAMGTVTAVELVSGSSADGSKDGTTVSRLFQPDKQEEKQDPPSHTPGPHHSPGGGQEPGDEPTPTPGASRPGGGADGRSPSPGPSSSSGGGSQQSPGPTPAPSGSPDGGKGTDEGKGGPSGAPATGSAPPPQGQNAAAGTGTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9H3</accession>
    <name>A0A2G1X9H3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">kdpC</name>
        <name evidence="13" type="ORF">BLA24_30705</name>
        <name evidence="14" type="ORF">CYQ11_23800</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47880">
        <property type="protein sequence ID" value="PHQ47880"/>
        <property type="gene ID" value="BLA24_30705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15505">
        <property type="protein sequence ID" value="PPT15505"/>
        <property type="gene ID" value="CYQ11_23800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304550" description="Potassium-transporting ATPase KdpC subunit" evidence="12">
        <location>
            <begin position="41"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="22787" checksum="132164581037D89F" modified="2018-01-31" version="1">MNNSVSNTARLLGAGLRALLVLTVVCGVIYPLVVTGIAQAVFHDKANGSEVTVDGKSVGSERLGQSYNLADRQDKDGNPLPDPRFFQPRVSAAGANTENTQYKIVVSGASNLAADSKVLLKSVEQRRADVAAFNGVRPSSVPVDALTASASGLDPDISPEYARLQAARVAKANGLPQGAVDRLVEDHVDGRILGFMGEERVNVLKLNVALQKLAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9K3</accession>
    <name>A0A2G1X9K3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF262 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30915</name>
        <name evidence="5" type="ORF">CYQ11_24015</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47914">
        <property type="protein sequence ID" value="PHQ47914"/>
        <property type="gene ID" value="BLA24_30915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15539">
        <property type="protein sequence ID" value="PPT15539"/>
        <property type="gene ID" value="CYQ11_24015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="2">
        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="3">
        <location>
            <begin position="419"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="588"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="862" mass="97213" checksum="C40199EC4D09BAF4" modified="2018-01-31" version="1">MQAKETLFADLVQGRAQQFQVPLYQRTYSWSEKQLAQLWNDILEQAELLESGATVNTHFLGSVVLAPSPQNEATFPRWLVVDGQQRLTTLSLALAAIRDHIVDGQPDEAERIDEEYLINKRKKGGDYFRLLPTQADRPQYAAHIHRVHSDRASGDRVAAAYRFFRRKLVEADDPTGAQDMLRIEQAITSRLTLVAVTAERGDNVHRIFESLNNTGLKLSQADLLRNYLFMRLPTRGEHVYESHWLPLQASLSNDELEQLMWLQLVLDGEDRVRRQDLYAAQQQRFERGRTDGADAEAEIESYIKELRRRGLLFRKVLHPVEETSLLVRGHLSRLHDWQAVVTYPALMLVLDRRARGELDERETARAMSYIESFLVRRTICRVPTNNLNRIFQSVPAQLPADVPVADGLHQLLSAENRFWPDDEELREKIRNAPFYQYGRPNQRRLVLQRLEESHEHPEPVDFGSAQLTIEHVMPQSPGEEWMRMLREDVTEGESPEDLHARLQHTLGNLTLTGVNSELSNHPFERKQGLLHGSHLEMNRRIAATERWGAREILDRADELADRAVRLWPGPLSGVGRAERSRDWHLAHQVLAGLPHGTWTSYGDLAAFIGSGAQALGSHLAKAEGVANAYRVLNADGRIAEGFRWTGQDGGDVRARLTADGIHFTVTGAADPVQRLTSDDLALLLAGTEGEDEPAVREGIAQDGGEPRGEETRAARFFRQLADDDSPSTVAAVRELFTRWEKLGGWIGHGAGEVTTSAFLMLGNAGSPGRGIWPLTVYPGSGRGGMAEVVFQHLASREPFTDRSLRAELLGRLNELEGVLIPEGKLELRPSFRLSLLENDRNREALCETLGWFRDRWEGRGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9K5</accession>
    <name>A0A2G1X9K5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30885</name>
        <name evidence="3" type="ORF">CYQ11_23985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47910">
        <property type="protein sequence ID" value="PHQ47910"/>
        <property type="gene ID" value="BLA24_30885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15535">
        <property type="protein sequence ID" value="PPT15535"/>
        <property type="gene ID" value="CYQ11_23985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="33465" checksum="64E5CE236574DA7F" modified="2018-01-31" version="1">MTAPRRGPASRAADALASPVLNNLIGLVGIVTPIVAWLSARGTAKNVLLVAETVIVMVLVGSHIWLRQRFITLRRANNLRSMDDAHYYDLVRAKLENELIADYNAVADGHVQVYAGEVPRLSVMLVNTLVESGSQPQRILAADLTTNPALLTGRRDYLAANRQFLQNGGTINRLFIAFESDLLREDYARDLLNVITHHRDLGVSCGLAVRDRLRADQAVDVVILSRAAALVEEEQGDADYTKGRSTMHFKGVDRWISRFESIWGNGTDSAPTTLRTYETAVRPLLETTWDEDRVRHVVDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9P8</accession>
    <name>A0A2G1X9P8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31235</name>
        <name evidence="2" type="ORF">CYQ11_24275</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47941">
        <property type="protein sequence ID" value="PHQ47941"/>
        <property type="gene ID" value="BLA24_31235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15565">
        <property type="protein sequence ID" value="PPT15565"/>
        <property type="gene ID" value="CYQ11_24275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="366" mass="38529" checksum="C5BD8B905AFA8676" modified="2018-01-31" version="1">MSTLILPASDIARIVQLVGRDTLMDRMIDRMACGIAALGRGEVEPTPRRGGFTRDSDGVGVIEWMPHHEPGKGMTLKTVGYTPSNPTNNDLPTILGTVARYDDVTGQLVALADGVVPTAIRTGAMSAVASRLLARPDSTTVGLIGAGAQSVTQLHALSRVFDVRRVLVHDIDPEHTASFASRVAFLGPDLDIQLVTAERVAAESDVICTATTVGVGEGPVLPDTVMRDHVHVNAVGADLPGKTELSAGLLARSLVTYDHLGQARVEGECQQLPEDAVGPSLASLCADPGSALPWRERSTVFDSTGFAFEDHLALDLFLELAIDFGLGQTVEVEYHPVDSLDPYPPLVDADSAAGVPVRHAVPSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9R5</accession>
    <name>A0A2G1X9R5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uma2 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31360</name>
        <name evidence="3" type="ORF">CYQ11_24400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47963">
        <property type="protein sequence ID" value="PHQ47963"/>
        <property type="gene ID" value="BLA24_31360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15587">
        <property type="protein sequence ID" value="PPT15587"/>
        <property type="gene ID" value="CYQ11_24400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="20203" checksum="E0B82419651D3BEF" modified="2018-01-31" version="1">MSTQPHTYAADDPESALKYAIRHIEGDRVQIVEGVISMMSPSWDHESAANSVRRQIERRVVELDCISGSGDLDLPGTPNWFIPDLAVVPASLAKDAGALVPDQTLLIVEVTSGSNGDTDRIVKRRRYAEYGAPLYLLVDREQRSCTLFSEPGELGYTKSDGPRPFGAPVRLPDPFELELDTSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9S6</accession>
    <name>A0A2G1X9S6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_31475</name>
        <name evidence="6" type="ORF">CYQ11_24520</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47980">
        <property type="protein sequence ID" value="PHQ47980"/>
        <property type="gene ID" value="BLA24_31475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15605">
        <property type="protein sequence ID" value="PPT15605"/>
        <property type="gene ID" value="CYQ11_24520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ47980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="28413" checksum="98AE3B2A2B4FC2B9" modified="2018-01-31" version="1">MIHVTAAPVLALRGISKRFGAVQALTDVELEIHPGEVVALVGDNGAGKSTLVKTIAGAGPADDGVIEWEGRPVTIDRPHTAQELGIATVYQDLALCDNLDVVGNLFLGREITRAGVLDEVEMERRSRELLSTLSIRIPSVRIPIASLSGGQRQTVAIARSLLGEPKIVILDEPTAALGVEQTAQVLDLVERLRERGLGVILISHNMADVKAVADRVAVLRLGRNNGTFDVRTTSQEEIISAITGATDNAVTRRKARTAQSESAEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9U2</accession>
    <name>A0A2G1X9U2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">dxs</name>
        <name evidence="13" type="ORF">BLA24_31485</name>
        <name evidence="14" type="ORF">CYQ11_24530</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47981">
        <property type="protein sequence ID" value="PHQ47981"/>
        <property type="gene ID" value="BLA24_31485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15606">
        <property type="protein sequence ID" value="PPT15606"/>
        <property type="gene ID" value="CYQ11_24530"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="12">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ47981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="658" mass="70188" checksum="1A15921C7415CA0B" modified="2018-01-31" version="1">MALLTRIREPRDLDRLTPEQLDRLAAEIRTFLVDAVSKTGGHLGPNLGVVELTIALHRVFDSPKDKILFDTGHQAYVHKLLTGRQDFSRLRAKGGLSGYPSREESEHDVIENSHASTVLGWADGLAKANQILDKKDHVVAVIGDGALTGGMAWEALNNIAVAKDRPLVIVVNDNERSYEPTIGGLADHLATLRTTDGYERFLARGKDLLERTPVVGKPLYETLHGAKKGLKDFIAPQGMFEDLGLKYVGPIDGHDIEALESALQRAKRFGGPVLVHCLTQKGRGYKHAEQNEADRFHGIGAIHPDTGLPVASGGASWTSVFADEMVKLGQEREDIVAITAAMMQPVGLGKFAKAFPGRVYDVGIAEQHAATSAAGLATGGLHPVFAVYATFLNRAFDQVLMDVALHRCGVTFVLDRAGVTGDDGASHNGMWDMSILQVVPGLRIAAPRDADQVRAQLREAVEVKDAPTVVRYSKGTVGPAVEAVDRVGGMDVLRRPAPGTERPDVLVVSVGALAPMCLEIADLLDKQGISATVVDPRWVKPVDEALPGLAAEHRVVVTVEDNGRVGGVGAAIAQALRDAGVDLPLRDFGIPPRFLDHASRKEVMAEIGLTAPDIARQVTGLVAKLDGRYEEAGPVGTGEDAVAPEAGGSAEPAEAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA01</accession>
    <name>A0A2G1XA01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31860</name>
        <name evidence="4" type="ORF">CYQ11_24915</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48048">
        <property type="protein sequence ID" value="PHQ48048"/>
        <property type="gene ID" value="BLA24_31860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15674">
        <property type="protein sequence ID" value="PPT15674"/>
        <property type="gene ID" value="CYQ11_24915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="164" mass="17089" checksum="D8A67582C4952014" modified="2018-01-31" version="1">MRVNFTVNGRPQEADDVWEGESLLYVLRERLGLPGSKNACEQGECGSCTVRLDGVTVCACLVAAGQAEGCEVTTVEGLAGRAGLPDGELTPVQQAFVDAGAVQCGFCTPGLLVAADELLECDPDPSDADIREALSGNLCRCTGYEKILDAVRLAAARTGEAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA53</accession>
    <name>A0A2G1XA53_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32230</name>
        <name evidence="4" type="ORF">CYQ11_25285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48108">
        <property type="protein sequence ID" value="PHQ48108"/>
        <property type="gene ID" value="BLA24_32230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15734">
        <property type="protein sequence ID" value="PPT15734"/>
        <property type="gene ID" value="CYQ11_25285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="116" mass="12798" checksum="354DA4C56F8F4A13" modified="2018-01-31" version="1">MPADSPLSDRLDDDDYPAYTMGRAAEMLGTTPGFLRAIGEARLITPLRSEGGHRRYSRYQLRIAARARELVDRGTPVEAACRIVILEDQLEEAQRINAEYRRTAKQASDSSGSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAT9</accession>
    <name>A0A2G1XAT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31965</name>
        <name evidence="4" type="ORF">CYQ11_25020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48354">
        <property type="protein sequence ID" value="PHQ48354"/>
        <property type="gene ID" value="BLA24_31965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16780">
        <property type="protein sequence ID" value="PPT16780"/>
        <property type="gene ID" value="CYQ11_25020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038762">
        <property type="entry name" value="ABM_predict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057">
        <property type="entry name" value="PTHR40057"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="101"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="34077" checksum="0797D144826C8097" modified="2018-01-31" version="1">MISQKVRAGRVGDYQRWQDRANEAAREFEGFEGAEAYPPEGGDENVWVAVFRFSGIDHLTAWLDSPRRRELLAEGQDLFEGPPTQEVLHGGAPAEQEPEAVTAVISHVVEPGREQGFLRWQAKALKAQEKAPGFMGSELFRPVQGVQERWVAVFRFDSREHLDDWLASDVRQELLEEGRHYFASYDVHKVGSAFSGWFRFEGGARGGAPPNWKQAMSVLLALYPTVMVLNLTVGYELDELGVPGYVGLFVGNVLSVSALTWLLMPLVNRALAFWLVPGRAPARVHVAGAALVVLAYLLFVVIFGLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX9</accession>
    <name>A0A2G1XAX9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32605</name>
        <name evidence="7" type="ORF">CYQ11_25655</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48376">
        <property type="protein sequence ID" value="PHQ48376"/>
        <property type="gene ID" value="BLA24_32605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16802">
        <property type="protein sequence ID" value="PPT16802"/>
        <property type="gene ID" value="CYQ11_25655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="126"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="390" mass="40773" checksum="51FB4EFBA9C971D5" modified="2018-01-31" version="1">MPADRDATVGAATSLLDAYEPGRARFFASPTRTLLAHGARAHVPHGDAPLARRVAETLDAELLAGNAAPVVVGAVPFDHTAPAALAVPEAVRWAPPLAEDPLVALPAAPPAPAAWDVRPVPEPGVYGDAVAEAVRRMNRGEFSKVVLARTLELRSSRDLDLPALLQRLARRDPTGYTFAVPSGPGRTLLGASPELLVSRRGGRLVANPLAGSTPRSADLAEDVRRAAALLESAKDLHEHAVVVDAVRAALAPYCRTLEVPARPTLVRTATMWHLSTTVTGEPADPAVSALELASALHPTPAVCGTPTATARDVIGELEPFDRGFFTGMVGWGDANGDGEWVVTIRCAEAAERSLRLYAGAGVVAQSSPEAETAETGAKFQTFLQAVGVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB43</accession>
    <name>A0A2G1XB43_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recN</name>
        <name evidence="10" type="ORF">BLA24_28995</name>
        <name evidence="11" type="ORF">CYQ11_06480</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48421">
        <property type="protein sequence ID" value="PHQ48421"/>
        <property type="gene ID" value="BLA24_28995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12583">
        <property type="protein sequence ID" value="PPT12583"/>
        <property type="gene ID" value="CYQ11_06480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="19"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="586" mass="60908" checksum="1DDF35DECA8265E8" modified="2018-01-31" version="1">MVVPVLEEMRIRSLGVIDDAVVELSPGFTAVTGETGAGKTMVVTSLGLLLGGRADPALVRVGAKAAVVEGRLALDGRSPAAVRAEEAGAELDDGTLLVSRTVSAEGRSRAHVGGRSVPVGLLGELADDLVAVHGQTDQQGLLRPARQRQALDRYAGAAVSAPLAKYADAYRRLRAVTAELAELTTRARERAQEADLLRFGLDEVAATEPLPGEDAELAAEAERLGHAESLASAATAAHAALAGNPEDPEGVDAATLVAGAHRALESVRSHDPALAALADRIGEIGILLSDVAGELAGYASDLDADPRRLAAVEDRRAALTHLTRKYDESGEGITAVLAWAERGAARLAELDGDDDRIGELTAERDALRAELGDLAQALTDARTEAAQRFAEAVTAELAELAMPHARVTFSIRQTEVADAASGIDVGGRAVTYGPHGADDVELLLTPHPGAQPRPIAKGASGGELSRVMLAVEVVFAGSDPVPTYLFDEVDAGVGGKAAVEVGRRLARLAQSAQVVVVTHLPQVAAFADRHLVVEKTHDGAVTRSGVQAMEGEARVRELSRMLAGQEDSELARAHAEELLAAARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBC2</accession>
    <name>A0A2G1XBC2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF5110 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29560</name>
        <name evidence="7" type="ORF">CYQ11_05915</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48505">
        <property type="protein sequence ID" value="PHQ48505"/>
        <property type="gene ID" value="BLA24_29560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12496">
        <property type="protein sequence ID" value="PPT12496"/>
        <property type="gene ID" value="CYQ11_05915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032513">
        <property type="entry name" value="AGL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16338">
        <property type="entry name" value="DUF4968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304609" evidence="3">
        <location>
            <begin position="35"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4968" evidence="4">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="5">
        <location>
            <begin position="619"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="753" mass="82614" checksum="18448E1719107C44" modified="2018-01-31" version="1">MTTRTRTRRLRAVIAAVLLGVLTATAGPVGGARASTAEETVGDVTGFSTAGPVFHLRAGQAEARVSFVTPETFRLELAPDGHFTDPTGKDIVLRQGPPPATRWKDKGDRYELSTAAVTLRAYKSPLRFALHRADGSRIWAETKGLTWAADKTTQTLARGADEQFYGAGMQNGRGNTSHRGKTVEVGVDYNWDDGGHPNSVPFYLSSAGYGVYRNTYAPGTYSFGDPVTATERERRFDAYYFAGDSAKDVIGKYTRLTGRPFLPPVYGLEIGDSDCYLHNKNRGERHTLDALKVADGYVAHDLPLGWMLVNDGYGCGYENLGETNKGLAGRGMKMGLWTEDGLTKLADQVKAGQRVAKLDVAWVGDGYKFALDGCKDAYKGIEDNSDARGFTWAPESWSGAQRCGVQWSGDQKGSWEYIRWQIPTYAGATMSGLAYTTGDVDGIFGGSPRTYVRDLQWKTFLPAVMTMDGWAPSDKQPFRYGEPYTSINRKYLKLKESLLPYMYSYAAEATRTGVGPVRPLALEYPHDPKAASDAAKYEFLSGEYFLVAPVYEDSGVRDGIYLPEGTWTDYWTGRTYQGPTTVDGYRAPLDTLPLFVKAGANIPMWPGIRSHEDRTADSPLAWDVYPRGTSSFTLYEDDGVTRAHRTGAYAQQRLTVRAPETGKGDVTLELGASLGDFRGKQTARPYHFTVHAATAPQAVTLEGSALPRLESEDAFDRAGQGWWYDRDDRGGAVKVKTAARSTDRAFTLALRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBD2</accession>
    <name>A0A2G1XBD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exo-alpha-sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29455</name>
        <name evidence="3" type="ORF">CYQ11_06020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48489">
        <property type="protein sequence ID" value="PHQ48489"/>
        <property type="gene ID" value="BLA24_29455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12512">
        <property type="protein sequence ID" value="PPT12512"/>
        <property type="gene ID" value="CYQ11_06020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="73" mass="7862" checksum="729A87F382068629" modified="2018-01-31" version="1">MISPMAATERDETRNRNGGRMTLRVSYDGGKTYGPARTVQVNPRNAVILGSPTKYPPCGCPRCTGRLPPPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCA7</accession>
    <name>A0A2G1XCA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1059 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27690</name>
        <name evidence="2" type="ORF">CYQ11_17950</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48848">
        <property type="protein sequence ID" value="PHQ48848"/>
        <property type="gene ID" value="BLA24_27690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14505">
        <property type="protein sequence ID" value="PPT14505"/>
        <property type="gene ID" value="CYQ11_17950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="63" mass="7060" checksum="13C06D49063B7597" modified="2018-01-31" version="1">MTRKVADCRKYPSESHCTLTISGEEDEVLRAAAEHAVSVHEHEDTPELREQIRGLLEDEKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCH6</accession>
    <name>A0A2G1XCH6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27655</name>
        <name evidence="3" type="ORF">CYQ11_17985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48936">
        <property type="protein sequence ID" value="PHQ48936"/>
        <property type="gene ID" value="BLA24_27655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16633">
        <property type="protein sequence ID" value="PPT16633"/>
        <property type="gene ID" value="CYQ11_17985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304841" evidence="1">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="21078" checksum="67DFB869267E48B1" modified="2018-01-31" version="1">MTTAAALAATGLLVTATPVTPASAAPPRTATAAERDPWHLVDRSPDLVRPKSLTVDASLPTHRARTAVRVTQRLYTFWNTGRARYLAGTVDPRFRDNTLPAGRPQGPAGLAFASKNFRAAVPDLTCELSDVLISGDKITARLVFRGHFTGTFQGRAGRGQKVEFAAIDIQHLGDDGLIVEDWHIEDNQTLLAQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM7</accession>
    <name>A0A2G1XCM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23190</name>
        <name evidence="4" type="ORF">CYQ11_22885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49007">
        <property type="protein sequence ID" value="PHQ49007"/>
        <property type="gene ID" value="BLA24_23190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15349">
        <property type="protein sequence ID" value="PPT15349"/>
        <property type="gene ID" value="CYQ11_22885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="31595" checksum="A418C8EE5A11C1BB" modified="2018-01-31" version="1">MIIGLVTAVAASACYGTGSVLQAVGSRKSARREAATASASGTTQHGGPSLSSTAKAAVTWEFMVGTVLDFVGFALGALAARMLPLFLSQTVISANLIVTALLSVKMLGLRLNRREWLSIGVVCSALVLLATAAGHEGSGEAARSTHWWLLIVSTVLMGGGWIAVHFLGSRAAILAGLLSGLGFGAIGVGVRILDGIDPFDLPTLLADPALYAILIAGGVGMYLHTVALQIGSVNGATAALVVGETVLPGIIGVMWLGDASREGFAWVAVLGFLLAVAGAVAVAWFGEPDAHGGAPETRDEERRPEPTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCP0</accession>
    <name>A0A2G1XCP0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_23150</name>
        <name evidence="5" type="ORF">CYQ11_22925</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49003">
        <property type="protein sequence ID" value="PHQ49003"/>
        <property type="gene ID" value="BLA24_23150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15352">
        <property type="protein sequence ID" value="PPT15352"/>
        <property type="gene ID" value="CYQ11_22925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="340" mass="36874" checksum="4DF8BE75C0FF58E4" modified="2018-01-31" version="1">MPALDSFIAGLPKAELHVHHVGSASPRIVAELAARHPDSPVPTDPEALADFFTFRDFAHFVEVYLSVVDLIRDAEDVRLLTYEVARDMARQNIRYAELTVTPYSSTRRGIPDVAFVEAIEDARKAAESELGVVLRWCFDIPGEAGLEAAEETTRIACDLAPQGLVSFGLGGPEIGVPRPQFKPYFDRAIAAGLHSVPHAGETTGPQTIWDALTELRAERIGHGTSATQDPRLLAHLAEHRIPLEVCPTSNLATRAVTDLDHHPVREMVQAGVLVTINSDDPPMFGTDLNTEYGVAARLLDLDARGLAELAKNAVEASFMDAAGKAALRAEIDSYTATWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCU6</accession>
    <name>A0A2G1XCU6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_23620</name>
        <name evidence="5" type="ORF">CYQ11_22450</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49077">
        <property type="protein sequence ID" value="PHQ49077"/>
        <property type="gene ID" value="BLA24_23620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15277">
        <property type="protein sequence ID" value="PPT15277"/>
        <property type="gene ID" value="CYQ11_22450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20821" checksum="BDE9455A389C8A27" modified="2018-01-31" version="1">MDFGTSSGEAARSTTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHAPDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGHQPYTPEEVREALQIGPDAPIITTDARHRNEAKSALITLVEHALMARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD43</accession>
    <name>A0A2G1XD43_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24155</name>
        <name evidence="2" type="ORF">CYQ11_21920</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49163">
        <property type="protein sequence ID" value="PHQ49163"/>
        <property type="gene ID" value="BLA24_24155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15187">
        <property type="protein sequence ID" value="PPT15187"/>
        <property type="gene ID" value="CYQ11_21920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="131" mass="13676" checksum="C3D722CC167C1FA0" modified="2018-01-31" version="1">MIILDTSATLALVQGHKTLNLLAVNMTRTGDQLVIPALCLMQAEAEDVGASRRALGLPCVTVDNLAMTAAVSVGKMIRDGYGGPDTCHALYCALPRAEFTGMSILLTGHEDAYPPGVVTVDIDSPGMLGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDA9</accession>
    <name>A0A2G1XDA9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24475</name>
        <name evidence="5" type="ORF">CYQ11_21595</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49224">
        <property type="protein sequence ID" value="PHQ49224"/>
        <property type="gene ID" value="BLA24_24475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15125">
        <property type="protein sequence ID" value="PPT15125"/>
        <property type="gene ID" value="CYQ11_21595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="109"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="371" mass="39804" checksum="E6FA45BACC5CE7C6" modified="2018-01-31" version="1">MTDDSRSPGAAPRRRARGKHGRRRKPPVRRTGRRIAAWSAGALVLLGGTGAGFLYFKLNGNLSSVDINAALGKNRPDNVDNGSMDILVLGSDSRAGDNDKYGRDEGSSRSDTAMIVHVYAGHKEASVVSIPRDTIISRPACTTPSGKTSPAVKREQFNEAYSLGGAVCAVKTVEAMTNIRMDHYLEVDFAGFQRLIDKLGGVEVTTTKPINDKWSHLKLDAGTHRLDGEQSLGLVRTRHGVGDGSDLGRIKLQQAFIKALLDQVKSIGLFTSPTKLYGIADTATKALTTDKDLASVDKLYGFANSLKGIGSEDMHMVTLPVGPDPRDSDRVVPLTAAAEQIWQAFREDKPVPEAALKEGDGAKTQADGVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDE5</accession>
    <name>A0A2G1XDE5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49252">
        <property type="protein sequence ID" value="PHQ49252"/>
        <property type="gene ID" value="BLA24_24640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013773747" evidence="2">
        <location>
            <begin position="20"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="569" mass="59902" checksum="A6F583EFFBD592D7" modified="2018-01-31" version="1">MRNAARRRMSRMRPDPARTCFRFTALGKKRAAAGAVLGGRRQGGEERAEAQERPYGRPGPGRCGEGPAPARPRRSRPAGPAGDRGPRPRGRRRSRAALPGSAGRGLGRGQRGRGGGTLYRPVTRRVPDKGGARPGAPSPAGRLARTRSGPEDLAFLLDGLHSRRLVLLKSLLTRLERRPSAVPGHARERFAEHWRLLERAEEHAPLPVRDTLDHPSVGNWLAAALTAADGEPLTRSLDHFGAVAATAALRAGTDFALDLAAPGGILALPGAGLARTGAETVRLTAHGRTARLTADGRRAGPVLLRAAGRLSGAGAGWQGLRRLPGSGACLDDLDPYRAPSGGVGRAALPAAPREAGGHEPWLRRWRAALALLRATDPQRAAETVALLRCLVPLARHGAGGRVLEAGAKASATFRAAPGAVFTTPPESAAELAEVLVHETQHSKLSVLHDLVPLHQAAPGAVHRVAWRADPRPLAGVLQGTYAHLALADFWDRAARRRPLPPAAAADARARRDSYGGQVAQALPILLESGELTPEGREFVEGMERHLAVLLGTAGHCAPFGGTSPAGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDK6</accession>
    <name>A0A2G1XDK6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="7">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">mgtA</name>
        <name evidence="19" type="ORF">BLA24_24750</name>
        <name evidence="20" type="ORF">CYQ11_21320</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49271">
        <property type="protein sequence ID" value="PHQ49271"/>
        <property type="gene ID" value="BLA24_24750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15077">
        <property type="protein sequence ID" value="PPT15077"/>
        <property type="gene ID" value="CYQ11_21320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="728"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="18">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PHQ49271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PPT15077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="847" mass="87445" checksum="9C742D846C37311A" modified="2018-01-31" version="1">MPGPDASVVWAPEARTAPGPGGGTTLEVLRALESGPRGLTEAEAEARLTHHGENVFAGRRPASWPRRFARSLRDPFTAVLLGLGLVSAAVAAWGTACVIAALVTVSGVLRATGEHRADRSAAALRDLVATTATVRRRATASAPPTARELPVDQLVPGDVVLLAPGDLVPADLRLLRATGLSVHEAALTGESAPAARNAQDPCLQGGSVVSGTGSGVVVATGRDTVLSGALPTPRHRSAPGPFHRSVNGIAWTLIRFMLLVAPLVVIAGALLRGRGLETLPFAVAVAVGLTPEMLPVIVTTALARGAALLARDREVIVRRLPALHDLGAVDTLCVDKTGTLTQDRPVVARALDADGHDDPDVLRWAAVNALWTVHLAELPVPDALDEAVLDAAEADAPGYEAEYEGVDALPCGPGRRLSTAVVRRPGDPRFALARTHTLVVKGAPEDVLDRCALAPAERERLVHRAADLAADGLRVLAVARAERPACEGPYTPADEHGLTFAGFVALSDAPAPTAAEALAELARRGVAVKVLTGDHPGTAARICRDLGLHPGAVLTADRLDALGDAELVRVARRTTVFARCSPEHKARVVEALRAGGRTTGFLGDGVNDLAALHAADVGICPRGGVDVAREAADVVLASKDLTALERAIVVGRRSTANIGSYLRITLSSNVGNVIAMLVAGLALPFLPMLPAQVLTQNLFFDAAQLALAFDDPGREAAARPAVLRPRALLRFVAGFGALNAAADLATFAVLALTAGEGPFHAGWFTENLLTQAAVMLLLRSGAGHAPGPLRFAVAGLGVAGLLLPVSPVGAALGMAPLSPLCYGLVGVVLALYGAALTVARRGWFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDT9</accession>
    <name>A0A2G1XDT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25140</name>
        <name evidence="3" type="ORF">CYQ11_20930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49339">
        <property type="protein sequence ID" value="PHQ49339"/>
        <property type="gene ID" value="BLA24_25140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15013">
        <property type="protein sequence ID" value="PPT15013"/>
        <property type="gene ID" value="CYQ11_20930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="13223" checksum="B0F97B8954E75EBA" modified="2018-01-31" version="1">MDRVNELPEYAERVLAVAELIPPGRVMTYGDVAEWLGEGGPRQVGRVMALYGGTVAWWRVVRADGVLLPGHELRALGHYRAEGTPLRERGTAGEGADGHMPRLAMARARWDGAGAPDVTPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDW3</accession>
    <name>A0A2G1XDW3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25460</name>
        <name evidence="3" type="ORF">CYQ11_20615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49395">
        <property type="protein sequence ID" value="PHQ49395"/>
        <property type="gene ID" value="BLA24_25460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14955">
        <property type="protein sequence ID" value="PPT14955"/>
        <property type="gene ID" value="CYQ11_20615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046095">
        <property type="entry name" value="DUF6113"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19608">
        <property type="entry name" value="DUF6113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="12770" checksum="C9991AD29A3E00D1" modified="2018-01-31" version="1">MNGGLISMPSAGRLVAYVGLVLLGLLVGAAGSLVQGGWFPGGLLLALLAVAGLCYGGLKVMGSRAGGGVPAVGWLAAVLFLAANRPEGDFLFEAGIGSYVFLLGGAIVAVICATIPKVPQPAGPPARLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEG7</accession>
    <name>A0A2G1XEG7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">N-acyl-L-amino acid amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26770</name>
        <name evidence="3" type="ORF">CYQ11_18865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49623">
        <property type="protein sequence ID" value="PHQ49623"/>
        <property type="gene ID" value="BLA24_26770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14656">
        <property type="protein sequence ID" value="PPT14656"/>
        <property type="gene ID" value="CYQ11_18865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="208"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="411" mass="43700" checksum="FD1AD7FA689EE1B6" modified="2018-01-31" version="1">MPCEADPETTDGELPGALPPGLRAELIAFRRDLHMHPELGNREYRTTAAVRARLEKAGLRPRTLTGGTGLICDVGRDGAAYPAGRGRPVLALRADLDALPIPDTKTVPYRSTIPKMAHACGHDVHTTVVLGAGLVLAELAEKGLLPHPVRLIFQPAEEVLPGGALDAIECGALDGVGRILAVHCDPKVEVGKLGLRTGAITSACDRVEVALAGPGGHTARPHLTTDLVTAAARVAADVPAVLARRADARSGLSLTWGRLETGHACNVIPQHAELSGTVRCLDVHTWRDAPDLVHAAVDEIATLHRAKSEITYMRGVPPVVNDPEVTALLRRAMTARRGRYALEDTEQSLGGEDFSWYLEHVPGAMARLGVRPVGDTTRRDLHCGDFDVDEDAIGVGVELFTAAALLDGNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEV5</accession>
    <name>A0A2G1XEV5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_26640</name>
        <name evidence="12" type="ORF">CYQ11_18995</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49756">
        <property type="protein sequence ID" value="PHQ49756"/>
        <property type="gene ID" value="BLA24_26640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16663">
        <property type="protein sequence ID" value="PPT16663"/>
        <property type="gene ID" value="CYQ11_18995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758495" description="Histidine kinase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="201"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="268"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="53494" checksum="9757EAA8A3958193" modified="2018-01-31" version="1">MRWISLRLRLMLVFALVALAAAVSASAIAYWLNRDAVLTRTQNAALDDFRKSLQDNTGSLPLTPTCPELQEAADRMAATSQKYEVLLIGKVKGGGDCAAPSDRDLFTLGVVPRTLVTAVNRERKVDESNPYPYHLYWQRITLGGKPYLVGGAKVIGGGPTGYLLKSLDNERADLNSLAWSLGIATGLALIGSALLAQAAASTVLRPVQRLGDAARRLGEGKLDTRLQVSGTDELADLSRTFNKTAESLQKRVEELSAREAASRRFVADMSHELRTPLTAITAVTEVLEDEADNLDPMIAPAVQLVVSETRRLNDLVENLMEVTRFDAGTARLVLDDVDIADQITACIDARAWLDAVELDAERGTMARLDPRRLDVILANLIGNALKHGGSPVRVSVRQTDDELVIAVRDHGPGIPEDVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAANSSDGGAVFTLTLPRDDSATVDDGEGPPSGDRAPEGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF41</accession>
    <name>A0A2G1XF41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49779">
        <property type="protein sequence ID" value="PHQ49779"/>
        <property type="gene ID" value="BLA24_19185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="92" mass="9650" checksum="37A24FA5A01BA155" modified="2018-01-31" version="1" fragment="single">MATVVERFRPRGSSALTTPEELADATPREVLHALGESLTEIATTSVIGLIGSIVASAMLTVVVSRRSWAARSPHGTPGRTHAPAARHGRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF79</accession>
    <name>A0A2G1XF79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49896">
        <property type="protein sequence ID" value="PHQ49896"/>
        <property type="gene ID" value="BLA24_19885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="180" mass="18160" checksum="D83782E49473F8D7" modified="2018-01-31" version="1">MAVLADKGRALRPDHFHLDFYDKNGGRWLPVRFERTDEAENVGVLDDRASDFPGFAIPAHGSVAVPLRLAFTPAAPGGPVTANVTAVQKRGTDGAWVGESDDYTFAVEPAAGPAPEPAGPPRHPGGAASPSGSPAPGVLADTGDLGALLGAGAVACALLAVGAVLVAGARTTRRKPPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB6</accession>
    <name>A0A2G1XFB6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20020</name>
        <name evidence="3" type="ORF">CYQ11_10770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49917">
        <property type="protein sequence ID" value="PHQ49917"/>
        <property type="gene ID" value="BLA24_20020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13308">
        <property type="protein sequence ID" value="PPT13308"/>
        <property type="gene ID" value="CYQ11_10770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="458" mass="49559" checksum="535E136D4AA58F0B" modified="2018-01-31" version="1">MASPHASSSPRPNTAFRELRGQRSPGEFAAAVRRAAREIGEHVSCDARYVGRVESGEIRCPNYAYERVFRHMFPGRDLADMGFAPREAVRGRGARKKGSAPPGHSESPAESRTPRAADSSTESSKESDVRRRAFMTSGTAAVAAVSLGGAPPARAQRRAGESEALAVEQAVRRIRLLDDRHGADGLYRRANRPLKAAYELLDAKTRRQSVADRLHAGAGELAISVGWLAHDSGRFADARSHYAEALATARVAGDPALEAHAFCNTAFLARDAGRPREAVRAAQAAQRAGRQLGSARLMSLLALREAGGWARLEDRPACEEALLRARALFERGRSDADPEWMTFFGEAELEGLEAQCWSALGDWRRAADHAERAVALQDRHFTRNIALYTAQLASDLARDGAAEEAAAAGGRALELLDQVQSARIRTMLTATARVLRRYAANPAVAEFLTRHAAAAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFE6</accession>
    <name>A0A2G1XFE6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20220</name>
        <name evidence="3" type="ORF">CYQ11_10570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49947">
        <property type="protein sequence ID" value="PHQ49947"/>
        <property type="gene ID" value="BLA24_20220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13276">
        <property type="protein sequence ID" value="PPT13276"/>
        <property type="gene ID" value="CYQ11_10570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="276" mass="29085" checksum="56E1D1AB4F50C4BC" modified="2018-01-31" version="1">MRGTERFSLNQATVRQWSLPDLVAGCAAAGVRHVGLWREPVREYGPAAVARLVRAAGLSVSSLCRGGFLTAPDPAGRAAALADNRAAIEEAAAVGTDTLVLVCGGLPPGSRDLAGARERVADALAALVPHAAGCGVRLAVEPLHPVFAADRCVVSTLGQALALAERFPAEWVGIVVDTYHLWWDDTVAEGLARAGEGGRIAAFQLADWVTPLPEGVLLGRGQLGDGSVDLRWFRERVEAAGYTGPTEAEIFSPALWARDGAQVLAETLERYRAHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFF1</accession>
    <name>A0A2G1XFF1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20305</name>
        <name evidence="9" type="ORF">CYQ11_10480</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49962">
        <property type="protein sequence ID" value="PHQ49962"/>
        <property type="gene ID" value="BLA24_20305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13261">
        <property type="protein sequence ID" value="PPT13261"/>
        <property type="gene ID" value="CYQ11_10480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="6">
        <location>
            <begin position="451"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="568" mass="58806" checksum="383A4F44DE6BC6A0" modified="2018-01-31" version="1">MKSVNVAVIEAARAGDAAAQDELVATHLPLVYNIVGRALNGHADVDDVVQDTMLRVINGLDGLRDPASFRSWLVAITMNQIRSHCREDRPEAPVSGLQEVVGEVADPKADFVDLTIVRLGLEGQRKEAAEATRWLDDGEQEVLSLWWLEAAGELKRAEVAAALELSPQHTAVRVQRTKAQLDIARGVVQALAAQPRCPQLGEVVAHWDGVPSALWRKRIARHVRSCGRCTGALSALVPAEGLLVGLGLVPVVGALAGWWGGGSDLGAAPVGYASHAPASSAAHSSAAYASPSASPSASAAGRPRSHRAGARHHRGGGGRSRATRRAVVGAGVLALVAGGVLGGMRFFEDEPGTTVKTQAADSSSDLKQLAAQEPSPLLPTPSQSATPSASASASPSPSASSPTPEQSSKAPEAKPSTAAPERTAPSRAEKSKAPAPGGKGGGGSMGQQVVSLVNAERAKVGCSPVTSNSLLDAAAQGHSDDMAARGFFDHTNPDGKGPGDRITAAGYQWSTYGENIAYGQQDAAAVMDSWMHSDGHRKNILNCSFKEIGIGINKAPGGPRWTQVFGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN8</accession>
    <name>A0A2G1XFN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00070</name>
        <name evidence="1" type="ORF">BLA24_20640</name>
        <name evidence="3" type="ORF">CYQ11_10140</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000004">
        <property type="protein sequence ID" value="PHQ53592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50021">
        <property type="protein sequence ID" value="PHQ50021"/>
        <property type="gene ID" value="BLA24_20640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53592">
        <property type="protein sequence ID" value="PHQ53592"/>
        <property type="gene ID" value="BLA24_00070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13201">
        <property type="protein sequence ID" value="PPT13201"/>
        <property type="gene ID" value="CYQ11_10140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="37951" checksum="796F63A2CFEDF83B" modified="2018-01-31" version="1">MNPNTPLSPRPLHHLSDVRHRILTSRQLREHGVPAATVAERCRPGGPWQQLLPGVFLLHTGPATSEERLHAALMYTLPRARVPAQPGPTSAAPRDAGADSYGQAMITGPAALALHRFTSVPSLLSLDHIDVLLPRTRRLRPTGFVRLVRAHTLPRTELLTGVPVAPAERAVADTVARMTESAAVRRLLAEAVRGGHCEAGALVGELSRARLLRRPYVADAVDALVTEGRAIAEGRLYEMVRAHALPAPLWNVELRLPGGPFLVGVDAYWPDHAVALELDLRNPRQEEDPWSEHLRGRAHMERLGITVVRLAPGMLRDAAALEQQAAVVRTALVASADREPGAYVVVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFV4</accession>
    <name>A0A2G1XFV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DegV family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein DegV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21050</name>
        <name evidence="3" type="ORF">CYQ11_09735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50085">
        <property type="protein sequence ID" value="PHQ50085"/>
        <property type="gene ID" value="BLA24_21050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13134">
        <property type="protein sequence ID" value="PPT13134"/>
        <property type="gene ID" value="CYQ11_09735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="281" mass="29069" checksum="D06C50A3743FCBA8" modified="2018-01-31" version="1">MSRHVAIITDSTAYLPQRAMERHSISAVPLTVVLGGEALEEGTEISARSVAEALRKRKPVTTSRPSPEVFAAAYRAAAEAGAEGVVSLHLSAEISGTYDAAVLAAREAPVPVRVVDTGMVAMALGFCALAAAETAQAGGTPDEVVAAAEKRAQGTAAYFYVDTLDYLRRGGRIGAAQALLGSALAVKPLLQLEGGRIELREKVRTASKAIARLEEIAVERAGAAPVDVAVHHLASPERAGSLAERLRERVPGLVDLHVSEVGAVIGAHTGPGLVGVVVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG46</accession>
    <name>A0A2G1XG46_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21785</name>
        <name evidence="5" type="ORF">CYQ11_09000</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50206">
        <property type="protein sequence ID" value="PHQ50206"/>
        <property type="gene ID" value="BLA24_21785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13010">
        <property type="protein sequence ID" value="PPT13010"/>
        <property type="gene ID" value="CYQ11_09000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="21677" checksum="4636057E53A43101" modified="2018-01-31" version="1">MLEQLGTLAGTPWIYVIVGLSVLLDVFLPVLPSGVLVITAATAAAGSAAGAVGDAAQGHAGFSDMLALVMCAATASVMGDMVAYRLAWRGGDRFDRAIARSRRLTAAQAKLGTALLRGGGPLVVLARFAPAGRSVVSLGAGVMHRRVAEFLPWSALAGLTWAAYSVSLGYFGGQWLGASWLSTAVSVLALFAAGSGAVYVMRREAPETQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGE3</accession>
    <name>A0A2G1XGE3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_22355</name>
        <name evidence="9" type="ORF">CYQ11_08430</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50297">
        <property type="protein sequence ID" value="PHQ50297"/>
        <property type="gene ID" value="BLA24_22355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12917">
        <property type="protein sequence ID" value="PPT12917"/>
        <property type="gene ID" value="CYQ11_08430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="84"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="31885" checksum="AD3BC88F58A66691" modified="2018-01-31" version="1">MGEATARTLEGRTAAPPPTEERGDRPPAGRPRPRAPRLLGRLRSPRHPRLWVEVLLIAVSYWMYSLIRNAVPEQRAAALRNADWIWQTEHTLHIAVEHTVNNAVNSVTWLVVGMNYYYATLHFVLTIGVLVWLYRWHPGRYAAARLVLFATTGVALIGYYLYPLAPPRLMTGPGFVDTVVVHHTWGSMASGNLADMSNQYAAMPSMHIGWSTWCGVTIAMLARRAWAKALGALYPLATLVVIVSTANHFWLDAVGGLLCLTLGGALSRLWYGAFPFRLARHVAVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGH3</accession>
    <name>A0A2G1XGH3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4191 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22540</name>
        <name evidence="4" type="ORF">CYQ11_08250</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50327">
        <property type="protein sequence ID" value="PHQ50327"/>
        <property type="gene ID" value="BLA24_22540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12886">
        <property type="protein sequence ID" value="PPT12886"/>
        <property type="gene ID" value="CYQ11_08250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="227" mass="24355" checksum="8E4EA290FF8B2114" modified="2018-01-31" version="1">MARKETSENPGRLQQIALTYKMTKKVDSKVGLVVAAVGMVTFGVLLAIGFWIDHPVYLGILGFLLAFLGMAIVFGRRAERAAFGQMEGQPGAAAAVLENIRRGGWTTTPAVAMNRNQDVVHRSVGKAGIVLVGEGNPNRVKALLAAEKKRMARIVADVPVHDIVVGDGEGQVPLKKLHTTLLKLPRVLPGAQVTAVNDRLRALGDLMSNMPIPKGPMPKGMRMPKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGJ6</accession>
    <name>A0A2G1XGJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19380</name>
        <name evidence="3" type="ORF">CYQ11_11420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50354">
        <property type="protein sequence ID" value="PHQ50354"/>
        <property type="gene ID" value="BLA24_19380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16496">
        <property type="protein sequence ID" value="PPT16496"/>
        <property type="gene ID" value="CYQ11_11420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="12942" checksum="7B17BA42A18B60F1" modified="2018-01-31" version="1">METYRALRAATGLGEKSVEGAAAGLPNTWYGVTVEHAGATVGMGRVVGDGGCHLQIVDICVLPEHQGRGLGRQIMEELTAELERRAPAGAYVSLIADGDARHLYAKFGFAETAPVSVGMARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGW6</accession>
    <name>A0A2G1XGW6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">BLA24_16715</name>
        <name evidence="4" type="ORF">CYQ11_16570</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50480">
        <property type="protein sequence ID" value="PHQ50480"/>
        <property type="gene ID" value="BLA24_16715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14265">
        <property type="protein sequence ID" value="PPT14265"/>
        <property type="gene ID" value="CYQ11_16570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="342" mass="36226" checksum="ECE08939BD46B5C7" modified="2018-01-31" version="1">MTLSLDQLSRCTVAVDLGAARTRVYLKDTGLVVDEPSLAAVNTRTGSLIAVGSLAEGMAGRTPHHIKVVRPISGGTVVDIDMAQRMLRFLVGNKLRRAWRRKPMVRAAVCLPHDAEPIAQRAAMETLSALGTRRVELVDTLIAAAVGCGLPVEQPEATMIMVCGAASTQVAVLSLGAIVAAEKVQVGGDAIDYAVVQHLRSEHELMLPSQGLHPLHLALFDRSAGGMETEVRGRDVATGLSRTVLVNTAHVREAIQTPLTAVLDAIGRVLRDCPPDLVADLAERGVMLAGGSAMLPGLDTMIEEATGMVVRIAEHPDVCSVMGLGAMMEGKVRPMHLDPLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGZ1</accession>
    <name>A0A2G1XGZ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16745</name>
        <name evidence="3" type="ORF">CYQ11_16540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50485">
        <property type="protein sequence ID" value="PHQ50485"/>
        <property type="gene ID" value="BLA24_16745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14260">
        <property type="protein sequence ID" value="PPT14260"/>
        <property type="gene ID" value="CYQ11_16540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="409" mass="43310" checksum="155A767CB9362D3A" modified="2018-01-31" version="1">MAVWDDLVGQDRVIEQLAAAARDADALVTTVESGHALTDALSPGGASRMTHAWLFTGPPGSGRATAARAFAAALQCVSPDRASSGGPGCGFCDGCHTTLVGTHADVEIVRTDLLSIGVKETRDLVRRAQLSPAGGRWQVIVLEDAGRLTEGAGNVLLKAVEEPAPRTVWLLCAPSVEDVLPTIRSRCRLLTLRTPPAAAVADVLVRRDGIDPELASQMARATQGHIGRARRLATDERARARRASVLKVPLRVADMGGCLKAAQELIDAAAEDAKQVAEEVDTKETEELRAALGAAAGTGGRLPRGTAGAMKELQDRQKRRATRTQRDSLDLALSDLTGFYRDVLAIQLGSRVEPANADAWDALQRIASSSRPESTLRRVEAIVACRQALDRNVAPLLAVEAMTVALRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH05</accession>
    <name>A0A2G1XH05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CsbD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16980</name>
        <name evidence="2" type="ORF">CYQ11_16300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50520">
        <property type="protein sequence ID" value="PHQ50520"/>
        <property type="gene ID" value="BLA24_16980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14225">
        <property type="protein sequence ID" value="PPT14225"/>
        <property type="gene ID" value="CYQ11_16300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="63" mass="7035" checksum="F1DB4B7B7E75CD0A" modified="2018-01-31" version="1">MTVSRAIRNQAQTMQGRITEELGRVARNRRLQRRGGADRVSGGLKQAVEKAKEAFRRNGSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHY3</accession>
    <name>A0A2G1XHY3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18950</name>
        <name evidence="4" type="ORF">CYQ11_14330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50836">
        <property type="protein sequence ID" value="PHQ50836"/>
        <property type="gene ID" value="BLA24_18950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13906">
        <property type="protein sequence ID" value="PPT13906"/>
        <property type="gene ID" value="CYQ11_14330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304874" evidence="2">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="163" mass="15243" checksum="90A3BE543AD080CC" modified="2018-01-31" version="1">MAAVSRIAAVAVATLALGGCMSVSDPGHPGPSGAGKQREAGTQSDAGIQIPGGRPGRTDAKAVRGGASGSPSAKGGRAEASSSASPSAAPGASPPAGHAGKPGQPQKPPTGPGQGVTPAPGKPSAPPQPPTQQPTPPAQQTPPPQPPGPSSPPPTQPGPAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHZ6</accession>
    <name>A0A2G1XHZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18390</name>
        <name evidence="4" type="ORF">CYQ11_14890</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50749">
        <property type="protein sequence ID" value="PHQ50749"/>
        <property type="gene ID" value="BLA24_18390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13993">
        <property type="protein sequence ID" value="PPT13993"/>
        <property type="gene ID" value="CYQ11_14890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="33113" checksum="DEF7321B052F38E6" modified="2018-01-31" version="1">MRERPKPPKSERTGGGPGPAGYAALVAVVLALTAVGLLVANSGLATDAPLADGDSSGHYRQPEDLAEKSAAAMRSAIRTVAPGPLTAPVARGTRTDKLPPSDPLTAQEAPASPAVGPLFYTGQGEPGHGCTASVVHSRRGDLLVTAAHCVHVGGFRTDLAFAPGYKDGVAPYGVWVPTAIDVDPAWVLRRDPDHDVAFVRVRPAEKNGGTPIERVTGAQAIAFDPPRGAPTRVLGYPSDSERPLACQNATEAESGTQVRFDCEGLPNGTSGSPFLTDVDPATGLGTVAGVLGGKDEGGDETTSYSTYFGEPVRKLYRRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XID0</accession>
    <name>A0A2G1XID0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_14415</name>
        <name evidence="6" type="ORF">CYQ11_13660</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50983">
        <property type="protein sequence ID" value="PHQ50983"/>
        <property type="gene ID" value="BLA24_14415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13795">
        <property type="protein sequence ID" value="PPT13795"/>
        <property type="gene ID" value="CYQ11_13660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="319" mass="33346" checksum="0D78A090D73B7B3E" modified="2018-01-31" version="1">MEEPPAGQPVIATRALTKRYRGGQLAVDRLDLTVPRGSVFGFLGPNGSGKTTTIRMLMGLVTPTSGTARVLGEEMPRAGGRVLPRVGALIEGPALYGFLTGRDNLLRFDAADPSADPRTRAARVDRALARVGLTAAAGKKARAYSLGMKQRLALAAALLQPRELLVLDEPTNGLDPQGMREIRALVRALAAEGTTVFLSSHLLDEIEQVCTHAAVMSRGRLLAQGTVAALASSARSRLAVTTADTTDAVRVLKEHGVNDLQVTEDRVTGELPTGAPVDLAALNAALVGAGVRVRAFGAERASLEDAFVALTGEGFDVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIE7</accession>
    <name>A0A2G1XIE7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="10" type="ORF">BLA24_14695</name>
        <name evidence="11" type="ORF">CYQ11_13375</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51028">
        <property type="protein sequence ID" value="PHQ51028"/>
        <property type="gene ID" value="BLA24_14695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13749">
        <property type="protein sequence ID" value="PPT13749"/>
        <property type="gene ID" value="CYQ11_13375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="43893" checksum="ADC66B559557D5E6" modified="2018-01-31" version="1">MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDAYPDLNPFTPFDEIDKAPEERQRGITISIAHVEYQTESRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTKEHVLLARQSGVPYIVVALNKADMVDDEEILELVELEVRELLNEYEFNGDDAPVVRVSALKALEGDKEWGEKLLGLMKAVDENIPQPERDVDKPFLMPIEDVFTITGRGTVVTGRIERGVLKVNETVDIIGIKTEKTTTTVTGIEMFRKLLDEGQAGENVGLLLRGIKREDVERGQCIIKPGSVTPHTEFEATAYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLKEGTEMVMPGDNAEMSVSLIQPVAMEEGLRFTIREGGRTVGAGQVTKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG1</accession>
    <name>A0A2G1XIG1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18970</name>
        <name evidence="3" type="ORF">CYQ11_14310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50919">
        <property type="protein sequence ID" value="PHQ50919"/>
        <property type="gene ID" value="BLA24_18970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16556">
        <property type="protein sequence ID" value="PPT16556"/>
        <property type="gene ID" value="CYQ11_14310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="158" mass="16939" checksum="BFA14B8B520BAE8B" modified="2018-01-31" version="1">MVIAEATQAGQAPALVGCAFGFPVRRDGAWWQGFSGVLPQDVEQLTASGHVFAITEIVVHPHERDRGLAGHLQERLLTSHHASLGATLVDQADRAACAAFRSWGWQDIGEFRWPPGPTVLRVLVLPLGERSAAKPDGLAHNADTERPRAADGVDPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XII9</accession>
    <name>A0A2G1XII9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mqnC</name>
        <name evidence="8" type="ORF">BLA24_14225</name>
        <name evidence="9" type="ORF">CYQ11_13850</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50949">
        <property type="protein sequence ID" value="PHQ50949"/>
        <property type="gene ID" value="BLA24_14225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13830">
        <property type="protein sequence ID" value="PPT13830"/>
        <property type="gene ID" value="CYQ11_13850"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="56"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="398" mass="44004" checksum="A00ABF2FFC278206" modified="2018-01-31" version="1">MTENADLQLVLDRAAAGGRITPEEALELYRSAPLHALGQAADAVRRRRYAGTEHIATYIIERNINYTNSCVTACKFCAFYAPPKSDKVWTRPLDDILRRCAETVELGGTQIMFQGGHHPDYGVEYYEEHFAAIKKEFPQLVIHSLGASEVEHMARISGVSAEEAIRRIHAAGLDSFAGAGAELLPERPRKAIAPLKESGERWLEIMELAHTLGVESTSTMLMGTGETNAERIEHLRMIRDVQDRTGGFRAFIPYTYQPQNNVLKGRTQATVFEYLRMIAVARLFLDNVAHIQGSWLTVGKEAGQLSLHYGADDLGSVMLEENVVSSAGAKHRSNRMELIDLIRKAGRVPAQRATTYEHLVVHDDPANDPVDDRVVSHLSSTAIEGGTAHPELKIVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ2</accession>
    <name>A0A2G1XIJ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsH</name>
        <name evidence="6" type="ORF">BLA24_14785</name>
        <name evidence="7" type="ORF">CYQ11_13285</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51043">
        <property type="protein sequence ID" value="PHQ51043"/>
        <property type="gene ID" value="BLA24_14785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13734">
        <property type="protein sequence ID" value="PPT13734"/>
        <property type="gene ID" value="CYQ11_13285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="14251" checksum="EABC445AE445114E" modified="2018-01-31" version="1">MTMTDPIADMLTRLRNANSAYHDSVAMPHSKIKAHIAEILQQEGYIAGWKVEDAEVGKKLVIDLKFGPNRERSIAGIKRISKPGLRVYAKSTNLPKVLGGLGVAIISTSHGLLTGQQASKKGVGGEVLAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIV6</accession>
    <name>A0A2G1XIV6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl carrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_15440</name>
        <name evidence="6" type="ORF">CYQ11_12635</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51155">
        <property type="protein sequence ID" value="PHQ51155"/>
        <property type="gene ID" value="BLA24_15440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13622">
        <property type="protein sequence ID" value="PPT13622"/>
        <property type="gene ID" value="CYQ11_12635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="75" mass="8389" checksum="4CBD975695EEF121" modified="2018-01-31" version="1">MITEQIHGIWSRELKLDDFSDDDDFFELGGHSLIMTRIQQALSDELGVDVPMDELFRKATVSAISAHVASLQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIZ5</accession>
    <name>A0A2G1XIZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xth</name>
        <name evidence="3" type="ORF">BLA24_15680</name>
        <name evidence="4" type="ORF">CYQ11_12395</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51195">
        <property type="protein sequence ID" value="PHQ51195"/>
        <property type="gene ID" value="BLA24_15680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13581">
        <property type="protein sequence ID" value="PPT13581"/>
        <property type="gene ID" value="CYQ11_12395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="29257" checksum="9BEA9F21458D824D" modified="2018-01-31" version="1">MPNLTVTTANVNGLRAAAKKGFVEWLALTEADVVCLQEVRAEPHQLPDEVREPEGWHVVHAPAAAKGRAGVSLYSRREPDAVRIGFGSAEFDGSGRYAEIDLPGVTVASLYLPSGEVGTERQDEKERFMAEFLPYLVGLKARAAAEGREVLVCGDWNIAHTEADLKNWKANRKSAGFLPEEREWLSKVFEEYTDVVRALHPGVEGPYSWWSYRGRAFDNDSGWRIDYLAATQGLAGRALKAHVERAATHAERWSDHAPVTAVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ22</accession>
    <name>A0A2G1XJ22_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_15830</name>
        <name evidence="7" type="ORF">CYQ11_12245</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51223">
        <property type="protein sequence ID" value="PHQ51223"/>
        <property type="gene ID" value="BLA24_15830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13553">
        <property type="protein sequence ID" value="PPT13553"/>
        <property type="gene ID" value="CYQ11_12245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="291"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="528"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="323"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="601" mass="66559" checksum="F63546D585138AE9" modified="2018-01-31" version="1">MAANLVNLEAVEKVYGTRALLDGISLGVNEGDRIGVVGRNGDGKTTLIRILAKLEDADKGRVTHAGHVRLGVLTQHDSLDPAATVRHEVIGDMADHEWAGDAKVRDVLTGLFGGLDLPAFPQGLDTVIGPLSGGERRRIALAKLLIAEQDLIVLDEPTNHLDVEGISWLAGHLRARRSALVCVTHDRWFLDQVCTRMWDVQRGAVHEYEGGYSDYVFARAERERIAASEETKRQNLMRKELAWLRRGAPARTSKPRFRIEAANELIADVPPPRDSAELMKFASSRLGRTVFDLENVTVQAGPKVLIEHLTWQLGPGDRVGLVGVNGAGKTSLLRTLAEAARTAGEKQPASGKVVVGKTVKLAYLSQEVAELDPAKRVLEAVQQVRDRVDLGKGREMTAGQLCEKFGFTKEKQWTPVGDLSGGERRRLQILRLLMDEPNVLFLDEPTNDLDIETLTQLEDLLDGWPGSMVVISHDRYFVERTTDRVFALLGDRFLRMLPRGLDEYLERRQKVMEAEAAAAPVAPAAAAKTKTAADARAAKKELQKIERRLDRISEQEAKLHERIAGQATDFEAVAKLDAELRELAGERDELELRWLELAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ29</accession>
    <name>A0A2G1XJ29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16000</name>
        <name evidence="4" type="ORF">CYQ11_12075</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51252">
        <property type="protein sequence ID" value="PHQ51252"/>
        <property type="gene ID" value="BLA24_16000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13522">
        <property type="protein sequence ID" value="PPT13522"/>
        <property type="gene ID" value="CYQ11_12075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045513">
        <property type="entry name" value="DUF6479"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20087">
        <property type="entry name" value="DUF6479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="143" mass="15826" checksum="C41C03A2C5F738C1" modified="2018-01-31" version="1">MRYEHTDLALPAWVGGVAPFIVGLFVVALLILAFVFGQRWRDKEPPPPSQPQRRQGAWQTREEHETGPTSPDHGPGHEDDNGRVDYVTEHREADPIQPEANGERVLPHEIRNPGSHPEEPSEERKKWEPGSSGSFGSGGAKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJE1</accession>
    <name>A0A2G1XJE1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14980</name>
        <name evidence="3" type="ORF">CYQ11_13090</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51345">
        <property type="protein sequence ID" value="PHQ51345"/>
        <property type="gene ID" value="BLA24_14980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16532">
        <property type="protein sequence ID" value="PPT16532"/>
        <property type="gene ID" value="CYQ11_13090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6491" checksum="93EEBDF704053CA9" modified="2018-01-31" version="1">MADRSQERPLPLSMRDLLASCAAADAVSTPPKAPREHEDREGAADPAEDTADEGRTTRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK7</accession>
    <name>A0A2G1XJK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13990</name>
        <name evidence="4" type="ORF">CYQ11_01685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51438">
        <property type="protein sequence ID" value="PHQ51438"/>
        <property type="gene ID" value="BLA24_13990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11779">
        <property type="protein sequence ID" value="PPT11779"/>
        <property type="gene ID" value="CYQ11_01685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="419"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="516" mass="55308" checksum="86295E0196CDD0E6" modified="2018-01-31" version="1">MTACAPVPAPRRLPELLSRTAARHPDRPALRADDEEMTFARLDDLTSRAAAWLHSLNIAPGDRVALLLPNVPAFAVLYYGVLRAGAVVVPVNPALKAREVAHCLADAGASLLLTWHEGADEAARGARWAGTRHHAVEPASLTAALQGHDPAGPAPGTSSDDTAVILYTSGTTGKPKGAELTHANLVANVAAAVDLMRLGPDDVVFGALPLFHSFGQVIGLNCAVATGACLTLLRRFDAARALSLIERERVTVFLGVPTMYTLLLGREDTADHDVSSLRLCACGGSPLPVEVLRGFEERFGCAVLEGYGLSESSPLACINRIDRERIAGTVGTPIDGVEMRIVDRWGKEVPDGETGEIVIRGHNVMKGYWRRPEATAEAVRDGWLHTGDLGTRDATGVFRVVDRIKDVIIRGGFNVYPREVEEALYRHPAVAEASVLGVPHPVHGEEVAAAVVLRAGAEATPEQIRDFVRDEVAGFKYPRVVWIADRLPKGPTGKILRREIVLPPELTAFTEGPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJV0</accession>
    <name>A0A2G1XJV0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_13475</name>
        <name evidence="10" type="ORF">CYQ11_01195</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51513">
        <property type="protein sequence ID" value="PHQ51513"/>
        <property type="gene ID" value="BLA24_13475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11695">
        <property type="protein sequence ID" value="PPT11695"/>
        <property type="gene ID" value="CYQ11_01195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="34105" checksum="167B12E9A1A9E455" modified="2018-01-31" version="1">MKSEHSERTEETAGRLAEDSCADPATETFVAHRNLLFTVAYEMLGSAADTEDVLQETWLRWAGVDLGTVRDQRAYLVRITTRQALSRLRTLGRRRESYVGPWLPEPLLTAPDVAEDVELADSVSMAMLLVLETLAPTERAVFVLREVFDLGYDEIAEAVEKSPAAVRQIAHRARAHVAARRPRGVVSPAETRDALDAFRRATETGDLQSLLDILAPDVVFLGDGGGVKQAVLRPVVGADKVGRLLAAGLGRITAESLRPAQVNGYPALILRQDGEIDTVVAVRIDDGLITGFYAVRNPEKLSHMEGENALCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJV5</accession>
    <name>A0A2G1XJV5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13890</name>
        <name evidence="4" type="ORF">CYQ11_01585</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51419">
        <property type="protein sequence ID" value="PHQ51419"/>
        <property type="gene ID" value="BLA24_13890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11760">
        <property type="protein sequence ID" value="PPT11760"/>
        <property type="gene ID" value="CYQ11_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304901" evidence="2">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="101" mass="10242" checksum="E81427E8B6E1F563" modified="2018-01-31" version="1">MLYRPRRSSLLLALLVAVAPVSPAGAAPATPAAPASTSAPPANSAYPVPVVLQPVTPPADGLLDAFLPGFLASLGSGIVLTIGGWGVKKGVKRLRERRPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJZ0</accession>
    <name>A0A2G1XJZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_13355</name>
        <name evidence="8" type="ORF">CYQ11_01075</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51491">
        <property type="protein sequence ID" value="PHQ51491"/>
        <property type="gene ID" value="BLA24_13355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11673">
        <property type="protein sequence ID" value="PPT11673"/>
        <property type="gene ID" value="CYQ11_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="388" mass="39937" checksum="CEA35FFBBFAAD6B8" modified="2018-01-31" version="1">MALSCLLVFMAQMATTIYLPSLPVVAEDFGMPRSYAALSISVFVIGAAAPVVVWGVAADRYGRRGPLLASLALFVLTSALTALIRSPEGLLVLRALQGVGAGGSAIIARILVRDRWSGDELARRLSVLSIAFITAMGGGQFLGGLIGRYAHWETGFVVLAVIGGAAAALTFTVPFESSRAVQRPSEVLRTCLTISRQRGFLLPALAGGAGFATIVLLQEVGPFVFQQHFGLAMDQYGSLGLLLGAAYFAGALTVNRLVSTVGSGRLMTAGAIVMTAAGIAMIVLWSVPGLPDGGALVVFVALYCVTTFGQSVLFPNSMATAVSSQHRHGASAVSLCGFLQQSMAGVAAATAALLHADLAWATVVAALGAAAWLMTRITVPSAVPGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK32</accession>
    <name>A0A2G1XK32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13585</name>
        <name evidence="3" type="ORF">CYQ11_01305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51531">
        <property type="protein sequence ID" value="PHQ51531"/>
        <property type="gene ID" value="BLA24_13585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11715">
        <property type="protein sequence ID" value="PPT11715"/>
        <property type="gene ID" value="CYQ11_01305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304828" evidence="1">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="182" mass="18701" checksum="98F522F4072C2119" modified="2018-01-31" version="1">MTVGVERVRAVALAAAVVLGVAAPVPATASPHGPGHAREPGLLQCQGTESVTYRPGVTFRARRVEVTVDGRFASCVGGGGEVKSGSYHERFTLFAGCNDLLEGFRSRRTYSWDTGDASTAEITGSSTAVAGQVVTPATGTVTHGRFHGRKLLQVIPLPQPSAPQCLSGGVTGATGVTTLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKF9</accession>
    <name>A0A2G1XKF9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_11700</name>
        <name evidence="6" type="ORF">CYQ11_02940</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51744">
        <property type="protein sequence ID" value="PHQ51744"/>
        <property type="gene ID" value="BLA24_11700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11992">
        <property type="protein sequence ID" value="PPT11992"/>
        <property type="gene ID" value="CYQ11_02940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="223" mass="24251" checksum="C7C32B604727A979" modified="2018-01-31" version="1">MRVVIAEDHYLVREGTRRLLEDTGHVTVVAAVGDATELLEAVGELRPEAVIADIRMPPSHHTEGIAAAHAIRVGHPGIGVVMLSQHADENYAFDLFQRGTDGLAYLLKERIGELDELLRALREVAAGRSVVDPRIVEVLMGSHTRAADAPLAGLTRRELDVLRHMAEGKTNRAIAAELVLSESTIEKHVNSTFAKLGLAEEPQLHRRVSAVLAYLRHAPRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKH6</accession>
    <name>A0A2G1XKH6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TIGR03557 family F420-dependent LLM class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11335</name>
        <name evidence="3" type="ORF">CYQ11_02570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51681">
        <property type="protein sequence ID" value="PHQ51681"/>
        <property type="gene ID" value="BLA24_11335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11930">
        <property type="protein sequence ID" value="PPT11930"/>
        <property type="gene ID" value="CYQ11_02570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="319" mass="34848" checksum="7A8D4F928B70C9DA" modified="2018-01-31" version="1">MTEYGYFLSCEENTPKDLVEQARMAEDAGFTSLWISDHFHPWCEAQGQSPFVWSVIGALARATSLPVQTAVTCPTLRMHPVITAQAAATSAALLGEGRFRLGVGSGEALNEHVLGDRWPPAAVRLEMLEEAVHVMRRLFEGGRVDHRGRHYTVENARLYTLPGEPVPVDVSAFGPAALELAGRIGDGLVAIKPEKQAVDGFRSHGGAGKPVFGGVKVCWGRDREAAIDLAHRRWAVEQLPGELNQVLPTPAHFEQAAQLVPRETVARNVTCGDDVDAHVATLREFADAGFDRVHVSQIGPDQRGFFDFYRAEVLPRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKS6</accession>
    <name>A0A2G1XKS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_12255</name>
        <name evidence="10" type="ORF">CYQ11_03490</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51843">
        <property type="protein sequence ID" value="PHQ51843"/>
        <property type="gene ID" value="BLA24_12255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12089">
        <property type="protein sequence ID" value="PPT12089"/>
        <property type="gene ID" value="CYQ11_03490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1456"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2954"/>
            <end position="3032"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4480"/>
            <end position="4555"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1491"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2992"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="4515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="4636" mass="484412" checksum="A3D11D792FC5B159" modified="2018-01-31" version="1">[encoded data, 4636 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKX7</accession>
    <name>A0A2G1XKX7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_01855</name>
        <name evidence="7" type="ORF">BLA24_01890</name>
        <name evidence="5" type="ORF">BLA24_03380</name>
        <name evidence="3" type="ORF">BLA24_11060</name>
        <name evidence="4" type="ORF">BLA24_11085</name>
        <name evidence="8" type="ORF">CYQ11_16905</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000132">
        <property type="protein sequence ID" value="PHQ51893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000132">
        <property type="protein sequence ID" value="PHQ51896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000034">
        <property type="protein sequence ID" value="PHQ53347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000034">
        <property type="protein sequence ID" value="PHQ53352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51893">
        <property type="protein sequence ID" value="PHQ51893"/>
        <property type="gene ID" value="BLA24_11060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51896">
        <property type="protein sequence ID" value="PHQ51896"/>
        <property type="gene ID" value="BLA24_11085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53125">
        <property type="protein sequence ID" value="PHQ53125"/>
        <property type="gene ID" value="BLA24_03380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53347">
        <property type="protein sequence ID" value="PHQ53347"/>
        <property type="gene ID" value="BLA24_01855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53352">
        <property type="protein sequence ID" value="PHQ53352"/>
        <property type="gene ID" value="BLA24_01890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14322">
        <property type="protein sequence ID" value="PPT14322"/>
        <property type="gene ID" value="CYQ11_16905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014078311" evidence="2">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="218" mass="22791" checksum="A8651D427E28B181" modified="2018-01-31" version="1">MRGLNKGARLGKPSLITGGAVTAMAAAAGLLLAGCGTSSDGVRKEGPAQTQSAAKAASRAPSAAASPAQKIDAVKLIKSDPKVSDQVKKNLKPCVKDEYPVDVIYGELTGEDRPDVVVNVLTCADSFGIGSYVYRAKGDAYENVFVAEQSPVYADIDRRDLTITKQVYGPGDAVCCPSGQDVLTYHWSDSAFQETGRTHTDYSKVGNTGKVPSEGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKY1</accession>
    <name>A0A2G1XKY1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12190</name>
        <name evidence="5" type="ORF">CYQ11_03430</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51831">
        <property type="protein sequence ID" value="PHQ51831"/>
        <property type="gene ID" value="BLA24_12190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12078">
        <property type="protein sequence ID" value="PPT12078"/>
        <property type="gene ID" value="CYQ11_03430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="919"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="988" mass="106068" checksum="E9080AFD7367E31A" modified="2018-01-31" version="1">MTTTSAGPAGGTAATSVPGTAKRTWTRGYTWHARPRLFTLRGDLTASARPARPHRREGRPVTLVERDADTSRLERFYDRIPACDPYGVLVVVSGAPGSGRSELLHHLADHAASRGGTTLHAVAAPEERHLPYALVDQLLCALPARGRHLRPQPAHAGPVALSPLQRLLAVRRALLAHRSSPNAPLLVTVDDVEFADPQSLRCLAHLLRHGRPGQLVVAVTHRQGVRVRLPGLGELHDLPGTLALRTRPLGVRGVGQFLTPHLGAGRGPRFAHAVHGLTGGSPLLLAALMSDRWAAKEPTAEDGEPQPGEQFRQAVLACVHRTGRQGLKVARGVALLGRTATAPLLTALTGVGDGALRASLAALQEAGVLDGMTFRHESARTAVLDDLPQEERARLSRHAAELLHHAGSPPTEVAAHLLAAASGPRRGTWAYGALTDAAGAALARGETALAWRCLRTAERHCRDERQRLALQAAQAQLTWRRAPSAAAGQVRALVAPARAGLLAPDASVRLASQLLWQGRMDDATEVFRKAGATARATPDPRLRTELSAFHQHVALSYPGVLEKAGLPDPYDFGDRPSPGAGQAAFRWRSQAALASVLLTHDAAPAPGDPEETLSGVPSAQQSLEVQEASLLALVHAGRLETAATWCERLLSEAERLKAPVTSAVLMGLRALIAARRGRLLDAAEHATAALRRMPDQSWGVGIGLPLSVLIYTGTAMGRHEEVTELLDRPVPREMFHTRYGLHYLYARGRHQLATGRAHAALADFVECGERMRRWHMDVPDLLPWRTGAAEAWLALNDTARAARYVDEQLSRSAGASTRARGAALRVLAATRPPAARRGLLERALEASRDAGDAYETARVLADLGGAHKEQKDSAKGRLLVRQALRAADECGAQELYRSLQPSPGRGAPPAPSGQDRRRATAESASLTAAERRVASLAAHGYTNRDIAAKLFITVSTVEQHLTRVYRKINIRHRKDLPTNLDFHVADTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL31</accession>
    <name>A0A2G1XL31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10795</name>
        <name evidence="3" type="ORF">CYQ11_00755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51932">
        <property type="protein sequence ID" value="PHQ51932"/>
        <property type="gene ID" value="BLA24_10795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11623">
        <property type="protein sequence ID" value="PPT11623"/>
        <property type="gene ID" value="CYQ11_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="256" mass="27468" checksum="B2CF5CADB7A9702D" modified="2018-01-31" version="1">MQATPHLVPRTADLFHQGLEHRTGSALLRFGAARQPSADRIGWSGDVAAAWLDAARGHVWSVGEPDAAAGLIVRAAHGLPGRVREFTGPRGTDVLVGRHLPVTGAVEWVFRWTLEEPPVHRAENRVVALDESHHEELLAFLNEHSPAHSTGPGSADVSLWAGIRDPDGDGRLVACGALSTLRDSGAPLMASVATDARLRGQGLGAALTSWLTRCAVRRHGLCTLWQLADNAPAERLYTRLGYRNEDPCVAARLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL41</accession>
    <name>A0A2G1XL41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate reductase ArsC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10860</name>
        <name evidence="3" type="ORF">CYQ11_00690</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51942">
        <property type="protein sequence ID" value="PHQ51942"/>
        <property type="gene ID" value="BLA24_10860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11614">
        <property type="protein sequence ID" value="PPT11614"/>
        <property type="gene ID" value="CYQ11_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="142" mass="15199" checksum="6DE454FDEF194A09" modified="2018-01-31" version="1">MPESKPSVLFVCVHNAGRSQMGAAFLTHLGAGRIEVRSAGSAPADTVNPAVVEAMREVGVDIAARTPKLLTTEAVQASDVVITMGCGDACPVFPGKRYLDWKLDDPAGQGVEAVRPIRDEIERRVRSLLVELLPPDTGRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL82</accession>
    <name>A0A2G1XL82_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10445</name>
        <name evidence="2" type="ORF">BLA24_18945</name>
        <name evidence="4" type="ORF">CYQ11_14335</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000121">
        <property type="protein sequence ID" value="PHQ51976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50835">
        <property type="protein sequence ID" value="PHQ50835"/>
        <property type="gene ID" value="BLA24_18945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51976">
        <property type="protein sequence ID" value="PHQ51976"/>
        <property type="gene ID" value="BLA24_10445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13907">
        <property type="protein sequence ID" value="PPT13907"/>
        <property type="gene ID" value="CYQ11_14335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="16171" checksum="20F5A865D6B47CA7" modified="2018-01-31" version="1">MGCRDRSPKRFAAPLPPTPRGAFVPDNGGVLEMTREDFEELVAEGLDRIPQELTRLMDNVAVFVEDEPPAEAPDLLGLYEGTPLTERGEWYAGVLPDRITIYRGPTLRMCGSREEVVEEVEVTVVHEVAHHFGIDDERLHALGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLA1</accession>
    <name>A0A2G1XLA1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000106">
        <property type="protein sequence ID" value="PHQ52015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52015">
        <property type="protein sequence ID" value="PHQ52015"/>
        <property type="gene ID" value="BLA24_10095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="151" mass="15904" checksum="0F913F2FFAC68F89" modified="2018-01-31" version="1">MLYVTVPLADASPRSAHSASSGLTADLQGRRGGRAGRPRRRRSSSAAELTSGAIPCWPRRPVGPRRDGTAVGQRPRAGRPRHAAAPEHPAYIVYTSGSTGRPKGVLVEHRALTTCSTSTSARSTPTCRPPGRAPLRAALTGATTFDAAWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLG4</accession>
    <name>A0A2G1XLG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09270</name>
        <name evidence="3" type="ORF">CYQ11_27880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52104">
        <property type="protein sequence ID" value="PHQ52104"/>
        <property type="gene ID" value="BLA24_09270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16184">
        <property type="protein sequence ID" value="PPT16184"/>
        <property type="gene ID" value="CYQ11_27880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="24138" checksum="C65FC302E3EBD41E" modified="2018-01-31" version="1">MTDPSERTARPPGPDPATDVVLDAKGLRALAHPVRVQLVGLLRLHGPSTATRLAERLSLASGVTSYHLRQLAAAGFVEEDTERGNARERWWRAVHRATWFTDKDLADSEPEAVLAYLRSVADTHTLRTRLALGQFPSMPRPWRDRLGLSDWVLRLTPEEARELGDELRSVLSRYRQEQLAPLDADPGPEGAERVMLVLHMLPEPADPDAAVENRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLI1</accession>
    <name>A0A2G1XLI1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09390</name>
        <name evidence="2" type="ORF">CYQ11_28000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52124">
        <property type="protein sequence ID" value="PHQ52124"/>
        <property type="gene ID" value="BLA24_09390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16204">
        <property type="protein sequence ID" value="PPT16204"/>
        <property type="gene ID" value="CYQ11_28000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="26869" checksum="A7226CCA08078086" modified="2018-01-31" version="1">MPSHTLKDKVVVIGGASRNLGSLIAREVAADGANVVVHYNAPSSKEGAEQTAEAVKAAGGDAVVHEADLTKVSEVEGLFEVAEGAFGKVDCVVNTAGMVIKKPMAEVTEAEYDRMFAVNSKAAYFMMQQAARRVEDGGKIITIVTSLLAAYTGLYSVYAGSKAPVEHFTRALSKELFGRNVSVNNIAPGPMDTGFFYPAETDDSIAYHKSSAMNGELTKIEDIVPYVKFLLTDGWWLNGQTLFVNGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLL4</accession>
    <name>A0A2G1XLL4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09465</name>
        <name evidence="3" type="ORF">CYQ11_28075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52138">
        <property type="protein sequence ID" value="PHQ52138"/>
        <property type="gene ID" value="BLA24_09465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16218">
        <property type="protein sequence ID" value="PPT16218"/>
        <property type="gene ID" value="CYQ11_28075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="191" mass="20602" checksum="4E1CF37923E2685D" modified="2018-01-31" version="1">MKDDDKLAFRFDCGAVWLNLLATRGRSFGADPVERVATPARLAEWLERSELAPARPPTPADLERARALRETLRVLALAVVGGEAPPGEAVAALERFLNAGGADPGPVRLAAAPGRLVCEPPPTTDAALVRIARQAVDHLTGVERHTLAVCPEHDCRGVFANPTGRRRWCPAPACASRGRVRALRERRRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLN8</accession>
    <name>A0A2G1XLN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_09815</name>
        <name evidence="15" type="ORF">CYQ11_04275</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52039">
        <property type="protein sequence ID" value="PHQ52039"/>
        <property type="gene ID" value="BLA24_09815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12220">
        <property type="protein sequence ID" value="PPT12220"/>
        <property type="gene ID" value="CYQ11_04275"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ52039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="22169" checksum="FD1BA755C2799F39" modified="2018-01-31" version="1">MEVQETRVQTDRVLTIPNILSMARLVGVPLFLWLILQKHDGWALVVLALSGISDYLDGKLARRWNQISNLGRLLDPAADRLYILSTLFGLTWREILPLWMTAALLAREAMLLVMVWILRRHGYPPPQVNFLGKAATFNLMYAFPLLLLSDGSGWLSSLAAIFGWAFAGWGTTLYWWAGILYVVQVRRLVRADATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM46</accession>
    <name>A0A2G1XM46_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08800</name>
        <name evidence="4" type="ORF">CYQ11_04060</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52286">
        <property type="protein sequence ID" value="PHQ52286"/>
        <property type="gene ID" value="BLA24_08800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16341">
        <property type="protein sequence ID" value="PPT16341"/>
        <property type="gene ID" value="CYQ11_04060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="470" mass="51776" checksum="01D5224D48B1F7DC" modified="2018-01-31" version="1">MLASPSKCPVHAYGPGGVARLYGPTAEDDPMGLYEQLRDRHGAVAPVLLHGDLPAWLVLGYRENLDVTRTPSRFSRDSRNWRDLREGKVPPDHPLTPITMWQPICAFADGSVHERWRGAINDSLGRFDRRGVRRHITRFADQLVDGFCAQGTAELVNDFAEHLPMLVMTQLLGMPEDYGPRLVKAARDMIRGTETAVASNEYVQETLRKLVVRKRSDPGPDFTSWLLEHPSQLSDDEVQQHLRLVLIAAFETTANLIANTVRMLLTDPRCRANLAGGHMTLPDAVEQVLWDEPPFTAILGRWATQDTELAGQQIKAGDVLVLGLAAANVDTAIRPDPTAPVHGNRSHLAFSGGAHECPGQDIGRAIADTGIEALLNRLPDVRLAVAEDELTWISSLMSRHLVALPVQFTPQEPNPVVQPETSPQAGPAHGSPEPHLPAADHPAANDSSPHLGSGTRTSWWRSLTRWLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM49</accession>
    <name>A0A2G1XM49_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07610</name>
        <name evidence="4" type="ORF">CYQ11_00040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52322">
        <property type="protein sequence ID" value="PHQ52322"/>
        <property type="gene ID" value="BLA24_07610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11525">
        <property type="protein sequence ID" value="PPT11525"/>
        <property type="gene ID" value="CYQ11_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HA" evidence="2">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="12137" checksum="2261C673CBD01F85" modified="2018-01-31" version="1">MSKLGVQPAEVSSPAPAATRATKGPSKAQAAFQRGLAALAQWVEREGDRPVPRGHSEQITVDGEAAPVTMKLGVWISNTKSRRNRLDAEQLAALAELGMDWARPVTVPQAAPGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM51</accession>
    <name>A0A2G1XM51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000092">
        <property type="protein sequence ID" value="PHQ52290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52290">
        <property type="protein sequence ID" value="PHQ52290"/>
        <property type="gene ID" value="BLA24_08445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="84" mass="9232" checksum="113033E911B510E0" modified="2018-01-31" version="1" fragment="single">MAYVTCLTGDACCATVEWHAHGGHRNPCACGISCEAQNGRRPALRDARRASDDQQAYVRQGARPECRGRRRRTTVGTRACLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XME7</accession>
    <name>A0A2G1XME7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_06570</name>
        <name evidence="12" type="ORF">CYQ11_26720</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52444">
        <property type="protein sequence ID" value="PHQ52444"/>
        <property type="gene ID" value="BLA24_06570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15976">
        <property type="protein sequence ID" value="PPT15976"/>
        <property type="gene ID" value="CYQ11_26720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="32"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="29850" checksum="AEF663AC009A990E" modified="2018-01-31" version="1">MTASASASVSPPRSRGRRPGALRIGLARGRVELLGIVREPMALFFTLCFPLFMMLMMGNVFQGDVADTGVPARQPLVAGMIGMGVMSSSFLSLAIGMAQDQSEGTLKRLWGTPAPYASYFIGKIVQVLVAVVLQTTVLLTVGVAAFDVRPPDTAGKWATLAWVVLLGTVACSMLGLLVGSLVRSGRAAPTVATAPFIVLQFISGVYFTLTSMPAWIQTAGALFPLKWVCQGIRSALLPDAFLAAEPAGSWEHAHTAMVLGAWTLAGFAAAVVAVRWQRRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMI0</accession>
    <name>A0A2G1XMI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06465</name>
        <name evidence="4" type="ORF">CYQ11_26615</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52426">
        <property type="protein sequence ID" value="PHQ52426"/>
        <property type="gene ID" value="BLA24_06465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15958">
        <property type="protein sequence ID" value="PPT15958"/>
        <property type="gene ID" value="CYQ11_26615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="358" mass="37976" checksum="05FE00164F353114" modified="2018-01-31" version="1">MTPTDDENVLLRTEGRAGYITLNRPKALNALNHAMALRVEEALTDWQKDPAVETVVVTGAGERGLCAGGDIRSIYEDARAGGSASADFWRDEYRLNALIARYPKPYVAVMDGIVMGGGVGVSAHGSVRIVTERSRVAMPETGIGFVPDVGGTYLLGLAPGGLGTHLALTGTAVGAADALLCGLADHYVPSELLPALTGDLAHAPLRDVLARHVRQAPPGELDAHRDWIDHCYAAATVEAIVDRLLDSGVPAAKDAATTLLAKSPTALKVTLAALRRARDLGPLERVLEQEYRVSCAALTSPDLVEGIRAQVIDKDRSPSWSPATLAEVTDADVARFFAPLGARELRLATSDRPQEVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMI5</accession>
    <name>A0A2G1XMI5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C(11)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cobM</name>
        <name evidence="8" type="ORF">BLA24_06690</name>
        <name evidence="9" type="ORF">CYQ11_26840</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52465">
        <property type="protein sequence ID" value="PHQ52465"/>
        <property type="gene ID" value="BLA24_06690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15997">
        <property type="protein sequence ID" value="PPT15997"/>
        <property type="gene ID" value="CYQ11_26840"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="256" mass="26894" checksum="79CF44989BD6BCEA" modified="2018-01-31" version="1">MTVYFIGAGPGAADLITVRGARTLARCAVCLYAGSLVPRELLAECPPDARLVDTARLDLDEITAEFVRAHEAGHDVARLHSGDPALFSAVAEQMRRLDALGIPYEIVPGVPAFAAAAAALGRELTVPTVGQTVILTRVAQRATPMPAGEDLATLGRSGALMVLHLAARHADRVVAELLPHYGADCPAAVVAMASRPDEIVLRGTLADIADQVKAAGVVRTAVIVVGRTLAAEQFPDSFLYSTTRDRDSCGRTVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMK5</accession>
    <name>A0A2G1XMK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase subunit CobN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06765</name>
        <name evidence="2" type="ORF">CYQ11_26915</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52477">
        <property type="protein sequence ID" value="PHQ52477"/>
        <property type="gene ID" value="BLA24_06765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16010">
        <property type="protein sequence ID" value="PPT16010"/>
        <property type="gene ID" value="CYQ11_26915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1199" mass="129467" checksum="E1F28DE21A39C849" modified="2018-01-31" version="1">MILLLSTSDTDLLSARAAGGPVPYRLANPARLPLDDLPELLEGTDLVVVRLLGGLRAWQEGLDQLLAQDRPVVVLTGEQAPDAQLMETSTVPVGIAAEAHAYLAHGGPANLEQLARFLSDTVLLTGHGFEPPAAAPSWGRLERTPKPGASGPLVAVLYYRAHHMSGNTAFVDTLCGAVEDAGGRALPLYVASLRAPEPELIEALRGADAIVTTVLAAGGTRPADASAGGDDESWDAGALTALDVPILQALCLTGPRSAWEENDEGLSPLDAATQVAVPEFDGRIITVPFSFKEVDEDGLPAYVADLERSARVAGIAVRHARLRHVPAADKRVALVLSAYPTKHSRIGNAVGLDTPASAVALLRRLREEGYDFGTEEVPGLASGDGDELIYALIEAGGHDQEWLTEEQLARNPVRIPAADYRRWYAQLPVELREAVEEHWGPAPGEMFVDRSRNPEGDIVLAALRRGNLLILIQPPRGFGENPIAIYHDPDLPPSHHYLAAYRWIAAAREDGGFGADAMIHLGKHGNLEWLPGKNAGLSAACGPDAALGDLPLIYPFLVNDPGEGTQAKRRAHATLVDHLVPPMARAESYGDITRLEQLLDEYAQISAMDPAKLPAIRAQIWTLIQAAKLDHDLGLEDRPDDDGFDDFLLHVDGWLCEVKDAQIRDGLHVLGGAPTGAARVNLVLSILRARQIWGGTSALPGLREALGLDESAATRTTADEAEDKARTLVQAMEDAGWDPAAVATAAAGHGPQVAEILDFAAREVVPRLAATTDEIDHAVHALAGGFVPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRLAWETGQALADSLLERYRTDNGEWPESVGLSLWGTSAMRTAGDDVAEALALLGVRPVWDEASRRVTGLEPVSLDELGRPRIDVTLRISGFFRDAFPHVIGLLDDAVRLVASLDEPADRNHVRAHAQADLAAHGDERRATTRIFGSRPGTYGAGILQLIDSRDWRTDADLAEVYTVWGGYAYGRGLEGRPAREEMETAYKRIAVAAKNTDTREHDIADSDDYFQYHGGMVATVRALRGTAPEAYIGDSTRPETVRTRTLVEETSRVFRARVVNPRWIEAMRRHGYKGAFELAATVDYLFGYDATTGVVPDWMYDKLAQTYVLDPENRAFLQEANPWALHGIAERLLEAESRGMWAKPDAETLEGLRQAFLETEGNLEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMN9</accession>
    <name>A0A2G1XMN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06735</name>
        <name evidence="4" type="ORF">CYQ11_26885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52473">
        <property type="protein sequence ID" value="PHQ52473"/>
        <property type="gene ID" value="BLA24_06735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16006">
        <property type="protein sequence ID" value="PPT16006"/>
        <property type="gene ID" value="CYQ11_26885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17767" checksum="EA220C51F8AE6799" modified="2018-01-31" version="1">MSGRARRVHPAVARAGTTRLFLWLAPRVLPRADRAVHRLTGGRWMPSRLFLPSVVLTTTGHRSGRPHATPLCAFRCPDGSRLVAATNFGRPRHPHWSANLLHRPEATVTYGGRTQPVTAHRLSPAAQRAERARSLAILPAYDHYAARVGDRGIRVFRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN06</accession>
    <name>A0A2G1XN06_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000080">
        <property type="protein sequence ID" value="PHQ52632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52632">
        <property type="protein sequence ID" value="PHQ52632"/>
        <property type="gene ID" value="BLA24_06445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="2">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="190" mass="20856" checksum="48F82B0CB71A1408" modified="2018-01-31" version="1" fragment="single">HLALYTFGVLKSPLADPARLTQEFYESGEAVYREIGQHPGYIAHAEPAEHSRGALFGSDWGAWGEFAVPAWYGKGRTAETTALAATLSLWTDLGSAIDAVYTGLHRVALNRRHDWFERTGHPSHVSWWVADGAIPTWQDGVTRLEHLHDHGYAPHAFTFHHSFDPAGTPARLKGIGPKGDMSVPDSPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN55</accession>
    <name>A0A2G1XN55_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ectoine dioxygenase</fullName>
            <ecNumber evidence="6">1.14.11.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ectoine hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thpD</name>
        <name evidence="11" type="ORF">BLA24_06155</name>
        <name evidence="12" type="ORF">CYQ11_03680</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate</text>
            <dbReference type="Rhea" id="RHEA:45740"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:85413"/>
            <dbReference type="EC" id="1.14.11.55"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. EctD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.55" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52684">
        <property type="protein sequence ID" value="PHQ52684"/>
        <property type="gene ID" value="BLA24_06155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12118">
        <property type="protein sequence ID" value="PPT12118"/>
        <property type="gene ID" value="CYQ11_03680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012774">
        <property type="entry name" value="EctD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02408">
        <property type="entry name" value="ectoine_ThpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="33883" checksum="43C04357DFCA70D5" modified="2018-01-31" version="1">MSSSSPAPDALHDPYPTRYVTESVPVDRSHPVVWGAPGDGPLDAERLAAYDRDGFLALDSLLTADQVGACQEEIGRFARDESLRTDERLVMEPESDGIRSVFEVHELSEVFAAVIRSEPLAGLARQVLGSEVYVHQSRVNYKAPFGGSRFGWHSDFETWHSEDGMPAPRALSLSVALTENLPFNGPLMIVPGSHRTFVPSVGRTPENYHKLSLLGKDLPAGSADRAGVTALAERHGIRQFTGAPGSAVMFDCNCLHASSGNASPFPRSNLFVVYNSVRNPLGSPYAAPRPRPRYLANRLIVPVPRTGSPASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNE8</accession>
    <name>A0A2G1XNE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginine 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">blsG</name>
        <name evidence="10" type="ORF">BLA24_05540</name>
        <name evidence="11" type="ORF">CYQ11_02000</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52736">
        <property type="protein sequence ID" value="PHQ52736"/>
        <property type="gene ID" value="BLA24_05540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11831">
        <property type="protein sequence ID" value="PPT11831"/>
        <property type="gene ID" value="CYQ11_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031015">
        <property type="entry name" value="Arg_2_3_am_muta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00291">
        <property type="entry name" value="arginine_2_3-aminomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04468">
        <property type="entry name" value="arg_2_3_am_muta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="120"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="388" mass="44013" checksum="C459DC865AC258A3" modified="2018-01-31" version="1">MSGTPGEHDTTTDPAGFRPRVPAAEWNDWRWHMRKRINTTDKARRWLRLTADEEKAIAASAGKYRWSITPYYASLMDPDDPACPVRLQAVPAPGELERFPGTDVDPVGDTYYRKTNRVVHKYPDRVIMLVTEACPVYCRHCTRKFHTTDVTGTYFRDDEGGSFDEDLRYIADHPEIRDVLLTGGDPLSYQDGKLEEIVSGLRAIPSVEIIRIGSRFPVLLPQRITDDLCAMLARHHPVWLNTHFNHPKEITPESAAAVDRLLRHGVPVGNQTVLLRGINDDVTTMRTLMTELLRIRVRPYYLYHCDNVTGVAHFMTSVEKGWEIMEGLQGHITGFAVPQYVLTTRIGKIPIARPYFTPTADGLLLRNYRGEEMVVGTAVHPITEPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNJ0</accession>
    <name>A0A2G1XNJ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05840</name>
        <name evidence="3" type="ORF">CYQ11_02315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52783">
        <property type="protein sequence ID" value="PHQ52783"/>
        <property type="gene ID" value="BLA24_05840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11885">
        <property type="protein sequence ID" value="PPT11885"/>
        <property type="gene ID" value="CYQ11_02315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304957" evidence="1">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="128" mass="13683" checksum="BC252EB5D914B155" modified="2018-01-31" version="1">MKRLAARTRRALCAGLVALGAVALLPATGTADAARCGGATCVIVEGAGRYVAKVSVQPAQDGDFFGHFHLRGAGLDGDSALRHWRHGQFYTVALGRKVPQHTVICAEGWEHVEEKVQPHGRVCVDVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW1</accession>
    <name>A0A2G1XNW1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_04920</name>
        <name evidence="6" type="ORF">CYQ11_28610</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52903">
        <property type="protein sequence ID" value="PHQ52903"/>
        <property type="gene ID" value="BLA24_04920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11437">
        <property type="protein sequence ID" value="PPT11437"/>
        <property type="gene ID" value="CYQ11_28610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="239"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="40890" checksum="5082F86295745497" modified="2018-01-31" version="1">MSNRVIHFPDQGLPGSVVYVEHGGESEHDDPDGHGDATGPEPAGTPVEVEARGRVEVPAGALLVYAADADGDALAGLAQCPPDAFVVVDVRGATDETVRSVGGLRDLRTLVLSGDFTDDCFEALRGLSSLGDMVVESPRFTGAGLASLAGSDTLDSLDSLIVCDGGAFDPASLRALAGAEALNSLTLENTRVDDALADAVLSLTPTLTDVSLTERPGHALEVAVLERLLRAGLTVNGVFAPPEHAAAFAAAAAAEGEDEDDLGGLPGGDRDERAPAPLRGVLRDLTDEAELNALLAGPTPVLVQLTAPWCGPCHVLTPVVEDVVEACGDGLRGAVVDVDAVEWAQERFDSLSVPTVVLLRDGAEVFRFHGVRSRRQLASWLEVAGVPATGRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP61</accession>
    <name>A0A2G1XP61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_04350</name>
        <name evidence="5" type="ORF">BLA24_04375</name>
        <name evidence="3" type="ORF">BLA24_15405</name>
        <name evidence="6" type="ORF">CYQ11_12670</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000067">
        <property type="protein sequence ID" value="PHQ52999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000067">
        <property type="protein sequence ID" value="PHQ53000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51149">
        <property type="protein sequence ID" value="PHQ51149"/>
        <property type="gene ID" value="BLA24_15405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52999">
        <property type="protein sequence ID" value="PHQ52999"/>
        <property type="gene ID" value="BLA24_04350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53000">
        <property type="protein sequence ID" value="PHQ53000"/>
        <property type="gene ID" value="BLA24_04375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13628">
        <property type="protein sequence ID" value="PPT13628"/>
        <property type="gene ID" value="CYQ11_12670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="32720" checksum="EB4ED37B8A13DA45" modified="2018-01-31" version="1">MVTLRQLQYMITIVEEGSFTRAARRLHISQPALSRQLQALERFCGGSLVERDARPLRLTPMGQAIHPHARAALAEADRIRLAAATAAGGPGGELRLATLDSLTLGVLPPALSAWHEGNPAMEVRLAEYRRAEELMAALGEGRADVAVGPALDQWYGPRQLLGVAEFVLVLPPDDPVAAAHPGPSVPLAAFTDRAWVHFAPANALSAVLNEACAEAGFTPRTAVRTEQSVAAPLLAASGLGPTLVPTYVLPAHFPGRVMRPEPPVRQQLFVCTTALPGPTVTDFVEVLVRHARVAPHTSLDDLGTASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP89</accession>
    <name>A0A2G1XP89_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04215</name>
        <name evidence="4" type="ORF">CYQ11_14045</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53030">
        <property type="protein sequence ID" value="PHQ53030"/>
        <property type="gene ID" value="BLA24_04215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13862">
        <property type="protein sequence ID" value="PPT13862"/>
        <property type="gene ID" value="CYQ11_14045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304984" evidence="2">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="239" mass="25173" checksum="5F591DAFB9E8B928" modified="2018-01-31" version="1">MHRRTAPRLARILACAAVPVMLVATGCSSDDSGGKKKESAKPTQSAKPTSTASVKPAAYGKLPEVCKTLSEKTVDKLVPKAEKKEGKALPSTDTNDSASCFWSGLNDEDVKDLQFRSLTVSLKRFPSDPTLGSGEKRAQDFAAQQTTKAATQDGAKDAKTEKAGDVGDDASVVSTQTKKDDNDFTNETVVARSQNVVVSVKYSGAGYEGAKSPNADDMKKDAQEAAKEVVAAVANANKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP91</accession>
    <name>A0A2G1XP91_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_04025</name>
        <name evidence="8" type="ORF">CYQ11_07290</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53058">
        <property type="protein sequence ID" value="PHQ53058"/>
        <property type="gene ID" value="BLA24_04025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16407">
        <property type="protein sequence ID" value="PPT16407"/>
        <property type="gene ID" value="CYQ11_07290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="309" mass="32530" checksum="0498D9D4279351B0" modified="2018-01-31" version="1">MHELPQVLVSGIALGALYGLIAIGYTMVYGIVQLINFAHGEIVMIGAFGALTIHLWLPDTIPLAATLPLMLLGGVIASVTVAGAAERFAYRPLRNAPRLAPLITTIGLSIALQQIVWAFYPDAKKSRSFPQFGDAFQLAGNLRLQRDDLFVLIAAPLCMLALGIFVAKSRTGRAMQATAQDPDTARLMGINTDRIIVLAFAIGGAFAAVAAVAQGLRAGQINFEMGFVLGLKAFTAAVLGGIGNIYGAMLGGVLLGIGEIASVTYIQHIPGMHQLGGGGWKDVWAFAMLIAVLLVRPQGLLGERVADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPA0</accession>
    <name>A0A2G1XPA0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan bridge formation protein FemAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000062">
        <property type="protein sequence ID" value="PHQ53040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53040">
        <property type="protein sequence ID" value="PHQ53040"/>
        <property type="gene ID" value="BLA24_04095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="358" mass="40837" checksum="1C6C3723EFEC6E48" modified="2018-01-31" version="1">MPAGRSPSWQAGQPGPWADVKAEWRSENLGWFDKTGQMVGAGLVLYRQLPKIKRYLAYLPEGPVINWFSPNLTDWLQPMLAHLKQQGAFSVKMGPPVVIRRWDANAIKTGIADPDVKRLRDVEATFIEPRAFEVADQLRRMGWQQGEDGGAGFGDVQPRYVFQVPLENRSLEDVHKGFNQLWRRNIKKAEKAGVEVVQGGYEDLATWQHLYEITAERDKFRPRPLSYFQRMWTALNSEDPNRMRLYFAVHEGEAVAAATMLIVGGHVWYSYGASANHKREVRPSNAMQWRMLRDAYALGASVYDLRGIGDSLDENDHLFGLIQFKVGTGGQAAEYLGEWDFPLNKLLHKALDIYMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPK0</accession>
    <name>A0A2G1XPK0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">BLA24_02025</name>
        <name evidence="3" type="ORF">CYQ11_04385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53146">
        <property type="protein sequence ID" value="PHQ53146"/>
        <property type="gene ID" value="BLA24_02025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12236">
        <property type="protein sequence ID" value="PPT12236"/>
        <property type="gene ID" value="CYQ11_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="262" mass="27004" checksum="84C56CC66491046D" modified="2018-01-31" version="1">MTPAATNAPPGPVLDLNADLGEGFGRWQLTDDDALLSVVTSANVACGFHAGDPSTMRRVCERAAERGVRIGAQVSYRDLAGFGRRAMDVPPEELADEITYQIGALRVFARAAGSDVTYVKPHGALYNRAVGDAEQAAAVVAGVLRAGGGLPVLGLPGSRLHEAAASAGLPVVAEAFADRAYTALGTLVPRRQPGAVIPGPDAVVARSVRIARAARVTALTGEEVAVRARSLCVHGDTPGAAQLARRVREGLVAAGVRVEAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPU9</accession>
    <name>A0A2G1XPU9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="10" type="ORF">BLA24_02890</name>
        <name evidence="11" type="ORF">CYQ11_05185</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53275">
        <property type="protein sequence ID" value="PHQ53275"/>
        <property type="gene ID" value="BLA24_02890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12370">
        <property type="protein sequence ID" value="PPT12370"/>
        <property type="gene ID" value="CYQ11_05185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="21091" checksum="07E430C8AAF8AB46" modified="2018-01-31" version="1">MIAFVSGPVAALAPDTAVVEVGGVGMAVQCTPGTLAGLRVGQHAKLATSLVVREDSLTLYGFADDDERQTFELLQTASGVGPRLAQAMLAVHSPDALRRAFAAGDEKALTAVPGIGKKGAQKLLLELKDRLGEPVGSARPAGAPAAAASGWRDQLHAALVGLGYAAREAEEAVTTVGPQAEAVLAEGGTPQVGQLLRAALQTLNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPW2</accession>
    <name>A0A2G1XPW2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_02955</name>
        <name evidence="3" type="ORF">BLA24_04305</name>
        <name evidence="5" type="ORF">CYQ11_05255</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000065">
        <property type="protein sequence ID" value="PHQ53006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53006">
        <property type="protein sequence ID" value="PHQ53006"/>
        <property type="gene ID" value="BLA24_04305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53287">
        <property type="protein sequence ID" value="PHQ53287"/>
        <property type="gene ID" value="BLA24_02955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12383">
        <property type="protein sequence ID" value="PPT12383"/>
        <property type="gene ID" value="CYQ11_05255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="91"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="28962" checksum="B66BD87037CD1B5E" modified="2018-01-31" version="1">MTFLHRRTVLRAAAGGALAGAVGGGVAGCGEGGRTVAAGASPRTPAPTTPAPRGTGGRPRASAPTPGPPLLLPGLPPGLPAQIENGPRRGRAVALTFHGRGDPKSATAVLAEAERAGARVTVLAVGDWLDAEPQMARRVLDGGHELGNHTMRHLAVCSMPEKAAYAEIAECAERLRRLTGGVGRWFRPSRARRATDQVVRLARKAGYPHVLSYDVDSLDFTDPGAEVVRRTVLNAVRPGSVVSLHFGHAGTVAAMPAILDGLHRRGLRAVTTTELLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPX9</accession>
    <name>A0A2G1XPX9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03005</name>
        <name evidence="3" type="ORF">CYQ11_05305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53294">
        <property type="protein sequence ID" value="PHQ53294"/>
        <property type="gene ID" value="BLA24_03005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12391">
        <property type="protein sequence ID" value="PPT12391"/>
        <property type="gene ID" value="CYQ11_05305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="178" mass="19881" checksum="514E8B2A717D7208" modified="2018-01-31" version="1">MLINHDIRRTLDAVVDLLNTELPDLPALREYVRRHDFSGIGALREPDLAAVRSARDRFIQVFDSQDARATADLLNALVAEAGTTPRLTDHDGYDWHVHYFAPGASLAEHLAADGGMALAFLLVEGELERLRRCGAPDCGRAFIDLSRNRSRRYCDGRTCGNRLHVAAYRARRREAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ20</accession>
    <name>A0A2G1XQ20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03125</name>
        <name evidence="3" type="ORF">CYQ11_05425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53310">
        <property type="protein sequence ID" value="PHQ53310"/>
        <property type="gene ID" value="BLA24_03125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12407">
        <property type="protein sequence ID" value="PPT12407"/>
        <property type="gene ID" value="CYQ11_05425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="18135" checksum="993B5327278990CB" modified="2018-01-31" version="1">MGMSVTISAAAETDAEQILKLQYLCYQSEAELYGDYSIEPLTQSLDDLRAELGSGCVLVARLGEEVVGSVRGTVDDDGTAVITGLIVHPRMQRHGLGGRLLGALETRLAGEWAARRFRLATGQRSEGNLRLYRKWGYEPTGTEEVTRKLTLVTLEKEATAVAFATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQD2</accession>
    <name>A0A2G1XQD2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00485</name>
        <name evidence="2" type="ORF">CYQ11_07495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53446">
        <property type="protein sequence ID" value="PHQ53446"/>
        <property type="gene ID" value="BLA24_00485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12751">
        <property type="protein sequence ID" value="PPT12751"/>
        <property type="gene ID" value="CYQ11_07495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="63" mass="7322" checksum="E7339E673694D9E9" modified="2018-01-31" version="1">MTDHIARWFRRVRALLAPIPTPPPPRRKPPHCPRATERPYTVVVSAHGINFIPRQPHRAQVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQE3</accession>
    <name>A0A2G1XQE3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_00610</name>
        <name evidence="9" type="ORF">CYQ11_07620</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53467">
        <property type="protein sequence ID" value="PHQ53467"/>
        <property type="gene ID" value="BLA24_00610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12772">
        <property type="protein sequence ID" value="PPT12772"/>
        <property type="gene ID" value="CYQ11_07620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="44"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="27343" checksum="05E91A8DABFDE736" modified="2018-01-31" version="1">MSAVAAAEGADRTRPPRRGAPLAPAARLLPALSAVYRAQLSRARVARIPLLFVATFQSVGIMILMRGVVDGGDEARAVVAGSSVLVVAFVALNLLAQYFGQLRAGGGLDHYATLPVPPAAVVLGAAGAYASFTVPGTAVTAVVGSVLFQLPMGHLWVLAAVIPLSGAALAGLGAALGLLAPRQELATLCGQLGMSAALLLGVLPAAHMPAPIAYARDLLPSTYGVEALARSFDARPDWLLVLADLGVCAAVGVVSLAVATWAYRRAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9B6</accession>
    <name>A0A2G1X9B6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_30380</name>
        <name evidence="6" type="ORF">CYQ11_23475</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47822">
        <property type="protein sequence ID" value="PHQ47822"/>
        <property type="gene ID" value="BLA24_30380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15447">
        <property type="protein sequence ID" value="PPT15447"/>
        <property type="gene ID" value="CYQ11_23475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="488" mass="50705" checksum="1DF2A7A5B6977E20" modified="2018-01-31" version="1">MALSKRPPTAPCGASPTTHEGILRRQASRESAARTYARSLPIVPVRARGMTIEGADGRRYLDCLSGAGTLALGHNHPVVLEAIRSVLDSGAPLHVLDLATPVKDAFTSELFATLPAGLAASARVQFCGPAGTDAVEAALKLVRTATGRDGLLAFSGAYHGMTAGALAVSGRAPSVRVARLPFPQDYRCPFGVGGDEGAHLAARWTESLLDDPASGVRPPAGMIVEPVQGEGGVLPAPDSWLRRMRDLTAARGIPLIADEVQTGVGRTGAFWAVEHSGVVPDVMVLSKAIGGSLPLAVVVYRDSLDVWQPGDHAGTFRGNQLAMAAGTATLRHVRENGLSQRAAALGERMLARLRPLVAEHDCVGDVRGRGLMMGVEIVDPEGAAHAAPWPGAEPGPGRATARVPLPAGPALATAVQQECLRRGLIVELGGRHDCVVRLLPPLTITDEQAEAVLERLSDAIATVSRTGHRIPTPRSPKEAGAAAPAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9D2</accession>
    <name>A0A2G1X9D2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RecQ family ATP-dependent DNA helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Recombinase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_30455</name>
        <name evidence="8" type="ORF">CYQ11_23550</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47837">
        <property type="protein sequence ID" value="PHQ47837"/>
        <property type="gene ID" value="BLA24_30455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15462">
        <property type="protein sequence ID" value="PPT15462"/>
        <property type="gene ID" value="CYQ11_23550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="242"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ47837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="721" mass="77545" checksum="E636C0BE79366E53" modified="2018-01-31" version="1">MTNEALRTSADTVLARLVGDSTGTARLREDQWRAIEALVADRRRALVVQRTGWGKSAVYFVATALLRERGSGPTVIVSPLLALMRNQVEAAARAGIHARTINSSNTEEWETIQAEVAAGEVDVLLVSPERLNNPDFRDQVLPKLAAATGLLVVDEAHCISDWGHDFRPDYRRLRTMLADLPPGVPVLATTATANARVTADVAEQLGTGEGAEEALVLRGPLDRESLSLGVLRLPDAAHRLAWLADHLDELPGSGIIYTLTVAAAEEVTAFLRRRGHTVASYTGKTENADRQQAEEDLLANRVKALVATSALGMGFDKPDLGFVVHLGSPSSPIAYYQQVGRAGRGVKHAEVLLLPGREDEAIWQYFASLAFPPEDQVRRTLDVLAAADRPLSLPALEPQVELRRSRLETMLKVLDVDGAVHRVRGGWTATGRPWSYDAERYAWVARQRAAEQQAMREYATTTECRMEFLRRQLDDEQAAPCGRCDNCAGARFAAEVSSGALDASRGELGRPGVEVEPRRMWPTGMPAVGVDLKGRIPAGEQAASGRALGRLSDIGWGNRLRPLLAPQAPDAEIPSDVADAVVTVLADWARGAGGWASGAPDAPSRPVGVVTLASRTRPVLIRSLGERIATIGRMPFLGTVEYRDTDTDTRIPRTNSAQRLRALDGALTVPPGLADALASAGGPVLLVDDLADTGWTLAVAARLLRKAGAKEVFPLVLAVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9J4</accession>
    <name>A0A2G1X9J4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Class I SAM-dependent RNA methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_30790</name>
        <name evidence="7" type="ORF">CYQ11_23885</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47895">
        <property type="protein sequence ID" value="PHQ47895"/>
        <property type="gene ID" value="BLA24_30790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15520">
        <property type="protein sequence ID" value="PPT15520"/>
        <property type="gene ID" value="CYQ11_23885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ47895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="442" mass="47944" checksum="60F9792C1CDE5013" modified="2018-01-31" version="1">MSMEPQESLVGEEYEVEVGPVAHGGHCVARTESGRVLFVRHALPGERVIARVTEGEETSRFLRADAVEVLEASKDRVEAPCPFSGPGKCGGCDWQHAKPGAQRRFKGEVIAEQLQRLAGLTPEEAGWDGTVMPAEGDKLPAGQVPAWRTRVQYAIDAEGHAGLRKHRSHEVQVIDRCLIAAPGVSELGVEKREWPQIASVEAIASSGSADRQVILTPKPGGRLPIVELDKPVSVLRVGEKDGRVHRVHGRPFVRERADGRTYRVGEGGFWQVHPQAADTLVQAVMQGLMPRKGDMALDLYCGVGLFAGALGERVGEKGAVLGIESGKRAVEDARHNLQDLDRVRIEHGKVEDVMPRTGINNADIVVLDPPRAGAGKKTVHHLASLGARRIAYVACDPAALARDLKYFSEVGYRVVKLRAFDLFPMTHHVECVAILKPTGNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA56</accession>
    <name>A0A2G1XA56_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain protein CspD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32205</name>
        <name evidence="5" type="ORF">CYQ11_25260</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48103">
        <property type="protein sequence ID" value="PHQ48103"/>
        <property type="gene ID" value="BLA24_32205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15729">
        <property type="protein sequence ID" value="PPT15729"/>
        <property type="gene ID" value="CYQ11_25260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7105" checksum="BBD965D87045B335" modified="2018-01-31" version="1">MASGSVKWFNAEKGFGFIEQDGGGPDVFAHYSNIAAQGFRELSEGQKVTFDIAQGQKGPTAENIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA75</accession>
    <name>A0A2G1XA75_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAP2 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32275</name>
        <name evidence="4" type="ORF">CYQ11_25330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48115">
        <property type="protein sequence ID" value="PHQ48115"/>
        <property type="gene ID" value="BLA24_32275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15740">
        <property type="protein sequence ID" value="PPT15740"/>
        <property type="gene ID" value="CYQ11_25330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="87"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="231" mass="24240" checksum="45A98B838BCD5216" modified="2018-01-31" version="1">MRGPGRAGFVGLAALACFALLAVAVVLRNGTPLPADVSLLSWAVGHRPDTAVTAARDVTSTGTDAVPYLLAALAGVIAGRTARQRLLAAAASLLCLGAGQALRQAVLHLVARSRPPVPDRVTHASGWSFPSGHATTAAITAALLITAVMLRSPRGRYVIAAVIGCWGAAVGLTRVYLGVHWFSDVIGGWLFALAWFTACLWAAARWLPPAVVPKRAENLRRRHERVRPTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAE6</accession>
    <name>A0A2G1XAE6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32755</name>
        <name evidence="3" type="ORF">CYQ11_25805</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48193">
        <property type="protein sequence ID" value="PHQ48193"/>
        <property type="gene ID" value="BLA24_32755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15819">
        <property type="protein sequence ID" value="PPT15819"/>
        <property type="gene ID" value="CYQ11_25805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="273" mass="30059" checksum="9009745643A780C9" modified="2018-01-31" version="1">MTTVAVAPDTGVGVGALLREWRDRRRISQLELALRADSSARHISFIETGRSRPSKDMVLRLADHLDVPVRERNALLIAAGYAPHYPERPLDDPALGDVREGLERLLKSYEPFPALVVDGTYQVLAANSGIAALLEGVAEPLLTPPLNAMRITLHPDGLAPRIRNFLEWRGHLLHQMERQLALMRSAPLRSLYDEVSTYPLPQPLGEERAAAAEGRLPFALPMVIEHRGRTLSFVSTIATFNTPMDVTVSELALETFLPADAETATALREGLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAN9</accession>
    <name>A0A2G1XAN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33440</name>
        <name evidence="3" type="ORF">CYQ11_26490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48307">
        <property type="protein sequence ID" value="PHQ48307"/>
        <property type="gene ID" value="BLA24_33440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15938">
        <property type="protein sequence ID" value="PPT15938"/>
        <property type="gene ID" value="CYQ11_26490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1391" mass="150811" checksum="E50A1496D476AA71" modified="2018-01-31" version="1">MPETIRWTVLPDGPAADGRLRLTVLVSPRLTGGTTLRSFPGFLDWPATLRRYTPELRVEFRAPGPGGPGAQVPVSPRQDRYPPASSDLWTQLFRADSTVRDPAGALTAAATGPLTLRSYPGRAVNERVAALYETAATATARRRAFPDGGSGQGAAAPPPATWDHPHPDELLGLLTEDVRTLGRTVTGSYTTLDGIITQGTGGRAADAAENPYRPRHMVRSRQEYRDHSPVLNFAEAYRFYDRPATPAPPPVTPADLDFHTACALLADYPELLRRFGLALDVLLDPPPGLADQWQARVVFTAAQQPLNEDAKLRPWTAVRFASGQRFEPYAADDAPHGRRMLRLGGPGVHVTDLDVDGAALSYVEFSRILDQTVRSLSDPALSGAPDGTAPPALHGAGFTVLLDDRDTALADRMEDDARHSAGVGPAGEPADAAVLDADHLVRGYRVDVGTVDTATGAVTAWHPLCARTGSHAVRRPGEPPVPLAVRPDEGHVKATAVTHDRTDSQQLYAHPALFGWHGWSLAAPPPGRTLGRGDRPQVPDPEVSPHFPLATAFRPVPGSLPALRYGRTYRLRARLCDLAGNGPDADAATPEGTAGPPVTYGRWEPVPPPVIVPRWPFLEGESETRLVIRSTVDDEGHPLSAGAWALQRNPQVPDHEADSPVDRLDRRYRGHDERHVSPPKTSLQMAEHHGMYDDALGPDRPDAVRRRFFAAASREAGSYLDTKVSPPQDPGVTFDLKALGRIHVAKHDVHDTVPLTELPVSRGSGLERGEYVVHDASQLLLPYLPDVLARGVSLRGLPGGAPNETYDFPGPWPEAKPLRLKIVEGDGPPFWSSLLERELTVRLPKATVATVRMSCRVDPEDLPLLRAWGLLTGSALWNDPVTGLPQAKKDELTAAAVDGENWMITPWTELTLVHAVEKPLEEPRLGTLAFPREAGATFTPFTGTLRSHAASSGRVDVDATWSERTDDPTQDAPQAVERHDRVGGLVLNPRDDTHSLFGLRHEFRDTRHRNVTYTPVATTRFREYFHPAITDRADLITRTGPASAGPSGRGWPVPSSRRPEPPVVSHMVPTVRWERSVDHSRHQVTRTRRHAGFRIHLQRPWFSSGDDELLAVLLDPGTDLPDELVSRCAADPVWADPTPLPRLTPAHFTNAAHVETGRVLAEAVRGQEASVSVAAFEPAYDPERRLWFCDVDIDLTAGQPTAGQAYFPYLRLALARYQPYSVDPLHLSKAVTSDFLQLLPDRTVTARTTGSGAIHLELGGPHSLNALGTRVGTGQAAVAAGRRVLAAVEQRPVGGGDLDWADAGPTVELGCTAAGPGFVWTADLVPPAPRLLPLSEYRLRVEEHERYATDDATADGTVTAGGTAVPVGHRLIHADHFPLVVSPLGRIVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAT2</accession>
    <name>A0A2G1XAT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketosynthase chain-length factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_33350</name>
        <name evidence="5" type="ORF">CYQ11_26400</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48289">
        <property type="protein sequence ID" value="PHQ48289"/>
        <property type="gene ID" value="BLA24_33350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15920">
        <property type="protein sequence ID" value="PPT15920"/>
        <property type="gene ID" value="CYQ11_26400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="415" mass="43299" checksum="48541845897FC031" modified="2018-01-31" version="1">MSTRRPPRAVVTGIGVIAPNGLRTDAYWKSVREGVVVLDRITREGCEHLPLKVAGQVEGFDAQALIEERFLVQTDRFTHYAMAAAALALDDAGLGHEAGEEPFSFGVVTAAGSGGGEFGQRELQKLWGQGSKFVGPYQSIAWFYAASTGQISIRHGFKGPCAVVAGDEAGGLESLAHAARAVRRGTGTVVAGAAEAPLAPYSMVCQLGYPELSTVEEPDRAYRPFTSAACGFVPAEGGAMLVLEDEQRARDRGAAVRAVVAGHGATFTGASRWTESREGLAHAIRVALDEAGCAPEEVDAVFADALGVPEADRAEALALADALGAHARRVPVTAPKTGSGRAYCGASVLDTAAAVLAMEHGLVPPTPNVFDIACDLDLVMSRARPAELRTVLVLSRGLMGTNAALVVRRDGDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAT5</accession>
    <name>A0A2G1XAT5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BLA24_30235</name>
        <name evidence="17" type="ORF">CYQ11_23330</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48325">
        <property type="protein sequence ID" value="PHQ48325"/>
        <property type="gene ID" value="BLA24_30235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16749">
        <property type="protein sequence ID" value="PPT16749"/>
        <property type="gene ID" value="CYQ11_23330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08971">
        <property type="entry name" value="AcNei2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044090">
        <property type="entry name" value="Nei2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="15">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="14">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ48325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PPT16749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="30262" checksum="2E8F9669A2E9854A" modified="2018-01-31" version="1">MPEGDTVWRTARDLHDALAGEPLIRCDLRVPKLATVDLTGRDVIEVVARGKHLLTRFAGGLTLHSHLGMDGAWRIHSVGERRHGGGGPHHQIRAILANSGHTAVGYRLPVLDLLRTPDESTVVGHLGPDLLGPDWDAGEAVRRLLSDPGRTVGEALLDQRNLAGIGNVYKSELCFLLRISPWAPVASLLDPERLVALAKKLLEANKSRTARITTADVRADRRLWVYGRADRPCRRCGSPVLRTEQGPAGQERITYWCPHCQTGPPPLAPPGPDEPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX2</accession>
    <name>A0A2G1XAX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30555</name>
        <name evidence="4" type="ORF">CYQ11_23650</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48329">
        <property type="protein sequence ID" value="PHQ48329"/>
        <property type="gene ID" value="BLA24_30555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16753">
        <property type="protein sequence ID" value="PPT16753"/>
        <property type="gene ID" value="CYQ11_23650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="241"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="353" mass="38439" checksum="F552B6124A257379" modified="2018-01-31" version="1">MAKRQIPVIVLAGFLGSGKTTLLNHLLARSGGSRIGAVVNDFGKIEIDAMTVAGQVDSMVSLGNGCLCCAVDTSELDGFLDRLSRPAARIDVIVIEASGLAEPQEIIRMILASENKSIVYGGLVEVVDAAEFSAVRATHPELDRHVAIADLVVLNKADRIGDEERESLLGTLAELAPGTPVVPVSYGRIDPELLFDRKPREDHREAVRQLTFEDLGADESACSSDDGHDHGHGCGHLHAAYESVEFISETPMNPRRLMEFLDGRPAGLYRIKGFVHFGVKGHRQKFTLHAVGDFLRFYRSAWARSEERATRLVMIGRGIDARALTDGLEACRDLAPQDAGPDSMWGVLRYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBA8</accession>
    <name>A0A2G1XBA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_29495</name>
        <name evidence="8" type="ORF">CYQ11_05980</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48495">
        <property type="protein sequence ID" value="PHQ48495"/>
        <property type="gene ID" value="BLA24_29495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12506">
        <property type="protein sequence ID" value="PPT12506"/>
        <property type="gene ID" value="CYQ11_05980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758387" evidence="5">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="7126" checksum="98830E22A9DF18EC" modified="2018-01-31" version="1">MLKKVVAAAAATSGLVLAGAGMAAASGGAQAAAVNSPGVASGNVVQVPVSVPVNLCGNTINVVGLLNPAAGNTCVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBK0</accession>
    <name>A0A2G1XBK0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">BLA24_28240</name>
        <name evidence="3" type="ORF">CYQ11_07230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48613">
        <property type="protein sequence ID" value="PHQ48613"/>
        <property type="gene ID" value="BLA24_28240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16406">
        <property type="protein sequence ID" value="PPT16406"/>
        <property type="gene ID" value="CYQ11_07230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="205" mass="21493" checksum="3391E586E92AE7E0" modified="2018-01-31" version="1">MLKVGLTGGIGAGKSEVSRLLASYGAVIVDSDRIAREVVEPGTPGLAAVVAEFGPGVLTADGTLDRPKLGAIVFADETRLAALNAIVHPLVRARAEALESAAPADAVVVHDVPLLAENGLAPLYDVVVVIDASPETRLDRLVRLRGMTPSEARARMAAQATREARLAVADVVIDNDVPLAELEPRVRTVWEDLRERAAGSPTEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBN3</accession>
    <name>A0A2G1XBN3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28560</name>
        <name evidence="4" type="ORF">CYQ11_06905</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48664">
        <property type="protein sequence ID" value="PHQ48664"/>
        <property type="gene ID" value="BLA24_28560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12655">
        <property type="protein sequence ID" value="PPT12655"/>
        <property type="gene ID" value="CYQ11_06905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758468" evidence="2">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="18649" checksum="BD27CE318B74C8FB" modified="2018-01-31" version="1">MTKVAAAGVVAEAALALTVLFLWAMAHPEPQPEGDPGPDSPALAIFVLPVLLPLVTAAALAFVSAFVLPTTLLARRAGSWWGGAGAWWWVPAAATAVAAVAVAAVGTGTGLTRGDAAAPAVYLWWWLGLTVATVPAALLARLSNLRDTTGRTPLRGRAVMGWGCGGAVGLVLGVVAVVGALDALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBT9</accession>
    <name>A0A2G1XBT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28665</name>
        <name evidence="2" type="ORF">CYQ11_06800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48682">
        <property type="protein sequence ID" value="PHQ48682"/>
        <property type="gene ID" value="BLA24_28665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12637">
        <property type="protein sequence ID" value="PPT12637"/>
        <property type="gene ID" value="CYQ11_06800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="63" mass="6581" checksum="042EE08E8173DBA2" modified="2018-01-31" version="1">MSMAVVGLAAGMVLGFAGYFGGFGAFLLVAALGAVGFVAGRFLDGDLEPGDFFRPRDHDGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBX4</accession>
    <name>A0A2G1XBX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-5 sterol desaturase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sterol desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28775</name>
        <name evidence="5" type="ORF">CYQ11_06690</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48701">
        <property type="protein sequence ID" value="PHQ48701"/>
        <property type="gene ID" value="BLA24_28775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12618">
        <property type="protein sequence ID" value="PPT12618"/>
        <property type="gene ID" value="CYQ11_06690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="33492" checksum="29089A394436DC3C" modified="2018-01-31" version="1">MPHLPDVVLWSVPAFVLLTVLELASYRLHPDDRLEGYEAKDAATSVGMGLGSLVFDALWKIPIVAVYTALYELTPLRVPVLWWTLPLMLLAQDFFYYWSHRGHHVVRVLWACHVVHHSSRKFNLTTALRQPWTSLTVWPFYVPMVLLGVHPAAVAFCSSVNLVYQFWVHTERIGTLPRPVEYVLNTPSHHRVHHASQGGYLDRNFGGILILWDRAFGSFVAEGERPVYGLTKNIATYNPLRVATHEYAALARDLRAARSWRERAGRVFRGPGWQPAGGGGASGAAAGGAGRASAGLPERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY6</accession>
    <name>A0A2G1XBY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28650</name>
        <name evidence="4" type="ORF">CYQ11_06815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48679">
        <property type="protein sequence ID" value="PHQ48679"/>
        <property type="gene ID" value="BLA24_28650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12640">
        <property type="protein sequence ID" value="PPT12640"/>
        <property type="gene ID" value="CYQ11_06815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="27748" checksum="99EA763564DEB031" modified="2018-01-31" version="1">MTARETLLDQDGVQLTVADAVATVTLTNPAKRNAQSPALWRALTEAGRLLPGTVRVVVLRGEGKSFSAGLDRQAFTPEGFDGEPSFLDLARGSDEALDAEIATYQEAFTWWRRNDVVSIAAVQGHAIGAGFQLALACDLRVCADDAQFAMKETSLGLVPDLGGTQPLVSLVGYARALEICATGRFVGADEAERTGLANLVVPLAELSAATDDLTAALLAAPRDAVVETKALLRGAAGRTYDEQRVAERAAQGRRLRDLAGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC21</accession>
    <name>A0A2G1XC21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine/betaine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27155</name>
        <name evidence="6" type="ORF">CYQ11_18500</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48760">
        <property type="protein sequence ID" value="PHQ48760"/>
        <property type="gene ID" value="BLA24_27155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14592">
        <property type="protein sequence ID" value="PPT14592"/>
        <property type="gene ID" value="CYQ11_18500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="42"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="376" mass="40504" checksum="E4D0005FBC12D37F" modified="2018-01-31" version="1">MPTVDTHDMTPDETSPVFSVRNLWKVFGPKAGRVPGGELAGLSPEELRERTGCTVAVRDVSFDVRPGECFVVMGLSGSGKSTLVRCLTRLIEPTSGTIAIDGEDVCGMDKGALRELRRHRAAMVFQHFGLLPHRTVLDNVAYGLEIQGVGKAERRSRAAEMVEKVGLTGMEERRPGQLSGGQQQRVGLARALAADPEVLLFDEPFSALDPLIRRDMQEEVVRLNRDEGRTMVFITHDLSEALRVGDRIALMRGGRIVQCGTPEEIVGSPADDYVRDFVRDVPREQVLTVRRAMRPVRDAREAETGPALAPATTVADAIEAVARTGTSARVVDAGRCLGVVDSTCLLGVVAGLDEARAANRGTGTGTLGEIKEKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCA4</accession>
    <name>A0A2G1XCA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27575</name>
        <name evidence="3" type="ORF">CYQ11_18070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48831">
        <property type="protein sequence ID" value="PHQ48831"/>
        <property type="gene ID" value="BLA24_27575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14523">
        <property type="protein sequence ID" value="PPT14523"/>
        <property type="gene ID" value="CYQ11_18070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="75" mass="8345" checksum="087D0F5507706814" modified="2018-01-31" version="1">MPEEELHSIRIHLDRILAERGMTLTELSAHVGITVVNLSVLKNGRAKAIRFSTLSRICDVLRCQPGDLITHDPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCF4</accession>
    <name>A0A2G1XCF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27980</name>
        <name evidence="4" type="ORF">CYQ11_17660</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48898">
        <property type="protein sequence ID" value="PHQ48898"/>
        <property type="gene ID" value="BLA24_27980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14453">
        <property type="protein sequence ID" value="PPT14453"/>
        <property type="gene ID" value="CYQ11_17660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="28627" checksum="0357201917258DE6" modified="2018-01-31" version="1">MPLVRTSELMSGASDGAVLAFNVITVEHAEAIAAGAESAGAGAVLQVSENAVRFHGGDLAPIAAATAAVARASRAPLALHLDHVESADLLRACAAHGFGSVMFDASKLPYAKNVKATAEAARWAHARGIWIEAEIGRVGGKPGDAHTPGVRTDPAEAAAYVADTGVDALAVAVGSSHAMTERTATLDHTLIAALRAAVPVPLVLHGSSGVPDAELRRAVAAGMKKINVGTALNAAFTGAVRAFLQAHPQTVDPRAYLAPAREAMAETVAGFLRAVRPRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCQ4</accession>
    <name>A0A2G1XCQ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23240</name>
        <name evidence="4" type="ORF">CYQ11_22835</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49016">
        <property type="protein sequence ID" value="PHQ49016"/>
        <property type="gene ID" value="BLA24_23240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15339">
        <property type="protein sequence ID" value="PPT15339"/>
        <property type="gene ID" value="CYQ11_22835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304576" evidence="1">
        <location>
            <begin position="33"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="63"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="187" mass="19420" checksum="2C3D9EBB91F16AC5" modified="2018-01-31" version="1">MRRPPTVTLRTLVLCTLSALFSWLACPPAAAGADRSWPVAGARGPRPLVVGAWDPPPVRWAAGHRGVDLAARPGTPVRAAAPGRVSFAGTVAGLGVVSVELGPGLRTTYEPVRATVREGDRVAAGDVVGVLQAGVLPHCRGGAGGASAGCLHWGLRRGEVYLDPLSLLPAWMLRRPPSRLLPLTDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCW8</accession>
    <name>A0A2G1XCW8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_23355</name>
        <name evidence="12" type="ORF">CYQ11_22720</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49035">
        <property type="protein sequence ID" value="PHQ49035"/>
        <property type="gene ID" value="BLA24_23355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15319">
        <property type="protein sequence ID" value="PPT15319"/>
        <property type="gene ID" value="CYQ11_22720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="7"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="423" mass="43866" checksum="5C465F89EF071CD6" modified="2018-01-31" version="1">MNGADTAFVLISAALVMLMTPALAFFYGGMVRVKSALNMLMMSFISLGIVSVLWVLFGYSLAFGDDIGAGLLGDLGHVGFKGITPETLTGGKEGIPVLAFALFQLMFAVITPALMSGALADRVKFSAWSLFITLWVTVVYFPVAHWVWQEDGWLFKLKVIDFAGGTAVHINAGIGALAAVLVVGKRVGFKKDPMRPHSLPLVMLGAGLLWFGWFGFNAGSALAANGVAANMAMNTQVATGAAMLGWLAYERVRHGAFTTLGAASGAVAGLVAITPSGAAVNAFGAILIGLVAGAVCSWAVSWKFRLGFDDSLDVVGVHLVGGVIGTLLVGLLATGGVGGLTQLGRQAAGAFSVMAYSFAVSWLLAKLVDKTVGFRASEDDEVSGIDQAFHAETAYDFSAVGGAPASRSGHQTPAQHLTKKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD44</accession>
    <name>A0A2G1XD44_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="3" type="ORF">BLA24_23785</name>
        <name evidence="4" type="ORF">CYQ11_22285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49105">
        <property type="protein sequence ID" value="PHQ49105"/>
        <property type="gene ID" value="BLA24_23785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15248">
        <property type="protein sequence ID" value="PPT15248"/>
        <property type="gene ID" value="CYQ11_22285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="10771" checksum="5773B196BBDF391A" modified="2018-01-31" version="1">MPGITREEVAHLARLSRLELKAEELDHFAEQLDVIIGAVARVSDVADEDVPPTSHPLPLTNVMRADEIRPSLTPQQALSGAPAQEQQRFKVPQILGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD53</accession>
    <name>A0A2G1XD53_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24280</name>
        <name evidence="3" type="ORF">CYQ11_21795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_071962662.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49187">
        <property type="protein sequence ID" value="PHQ49187"/>
        <property type="gene ID" value="BLA24_24280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15163">
        <property type="protein sequence ID" value="PPT15163"/>
        <property type="gene ID" value="CYQ11_21795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="34592" checksum="2D24C2DFD8A56ABB" modified="2018-01-31" version="1">MSDTSSPFGFELVRRGYDRGQVDDRITKLVADRDSALARITSLEKRIEELHLETQNAQAQINDAEPSYAGLGARVEKILRLAEEEAKDLREEARRAAEQHRELAESAAQQVRNDAESFAADRKAKAEDEGARIVEKAKGDAATLRAEAQKDAQSKREEADALFEETRAKAAQAAADFETNLAKRREQSERDLASRQAKAEKRLAEIEHRAEQLRLEAEKLRTDAERRARQTVETAQRQAEDIVADANAKADRIRSESERELAALTNRRDSINAQLTNVREMLATLTGAAVAAAGVPGDDEPISRGVPAQQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDG4</accession>
    <name>A0A2G1XDG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_24740</name>
        <name evidence="9" type="ORF">CYQ11_21330</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49270">
        <property type="protein sequence ID" value="PHQ49270"/>
        <property type="gene ID" value="BLA24_24740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15078">
        <property type="protein sequence ID" value="PPT15078"/>
        <property type="gene ID" value="CYQ11_21330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="87" mass="8954" checksum="06265895798F07DC" modified="2018-01-31" version="1">MEISGIISAIVIGAIIGVLGRLVVPGRQHIGVFTTILIGIAAALVGALIAHALGVDDTKGVDWIEWLIQIGLAALGVVAVDRARARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDK0</accession>
    <name>A0A2G1XDK0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_24945</name>
        <name evidence="10" type="ORF">CYQ11_21125</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49306">
        <property type="protein sequence ID" value="PHQ49306"/>
        <property type="gene ID" value="BLA24_24945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15043">
        <property type="protein sequence ID" value="PPT15043"/>
        <property type="gene ID" value="CYQ11_21125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="283" mass="30857" checksum="EDB55F07B324094D" modified="2018-01-31" version="1">MGSIACPSRPQTADLGWAVMGGAQPVAAGAAGGPDRRLFSDSSGSASGAARVLEEVGPVTGTDTGADDSQRREPGESAVERSARFERDALTFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKKQREPLRSASEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGTAAAPKGSDESHNRKGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDL8</accession>
    <name>A0A2G1XDL8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AIM24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25060</name>
        <name evidence="2" type="ORF">CYQ11_21010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49326">
        <property type="protein sequence ID" value="PHQ49326"/>
        <property type="gene ID" value="BLA24_25060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15026">
        <property type="protein sequence ID" value="PPT15026"/>
        <property type="gene ID" value="CYQ11_21010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="252" mass="27123" checksum="6A536E5316865E0A" modified="2018-01-31" version="1">MQSPLFGHTEAQTQDRYALQNPQLLRVSLTGHEDVLARKGSMVAYQGIIEFDAEYQTRGQQHARAHTGEGLDLMRCSGQGTLYFANLAQYVHVVDVDHQGLTVDGSYVLALDSTLHWDTYAVDSHHGISGAGSHQLNISGQGKVALMTSGQPLMLQVTPDKVVSADADAVVAWSTSLRVQMQAQTSSSGVWRRRGSTGEGWELSFAGHGYALVQPSELLPPQGAQIGQGLAAQYGFGQQGAHGQNHGNIWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDQ5</accession>
    <name>A0A2G1XDQ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25035</name>
        <name evidence="2" type="ORF">CYQ11_21035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49321">
        <property type="protein sequence ID" value="PHQ49321"/>
        <property type="gene ID" value="BLA24_25035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15030">
        <property type="protein sequence ID" value="PPT15030"/>
        <property type="gene ID" value="CYQ11_21035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="66" mass="7074" checksum="B6A190AE3ECE1D4E" modified="2018-01-31" version="1">MAALAWLLIPVAAAVVAALWGSWAARNRKTGDVAELAGYAKFREAMERTEIREAMERAESGSASGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDR8</accession>
    <name>A0A2G1XDR8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25395</name>
        <name evidence="4" type="ORF">CYQ11_20680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49384">
        <property type="protein sequence ID" value="PHQ49384"/>
        <property type="gene ID" value="BLA24_25395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14967">
        <property type="protein sequence ID" value="PPT14967"/>
        <property type="gene ID" value="CYQ11_20680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="26985" checksum="969514BB877A7554" modified="2018-01-31" version="1">MASSEERRTPREQRRGPVVRRHGQMQAGTTDQHLLDTRGTADWVHEDPFRVMRIQSEFVEGFGALAELPPAISVFGSARTRPGTPEYEAGVAIGRGLVEAGFAVITGGGPGAMEAANRGAMEAGGVSVGLGIELPFEQGLNQYVNLGVDFRYFFVRKTMFVKYASGFVVLPGGLGTLDELFEALTLVQTKKVTRFPIVLFGTGYWRGLVGWLRDTLVAEGKAGLHDLQLFHVTDDVQEAVGLVTKEAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE77</accession>
    <name>A0A2G1XE77_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26055</name>
        <name evidence="2" type="ORF">CYQ11_20010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49501">
        <property type="protein sequence ID" value="PHQ49501"/>
        <property type="gene ID" value="BLA24_26055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14848">
        <property type="protein sequence ID" value="PPT14848"/>
        <property type="gene ID" value="CYQ11_20010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19813" checksum="E68C333D2F798F79" modified="2018-01-31" version="1">MSVKEDQIIRELSHYLHEHPGDQMALMPVYDAALDHSRRQACTHDQRCPLVMTAAVVVDERDRVLCLRHQGGYALAEAEPEDQDDSLSEAALRLLVEEVGIRDVWTQPGNEGPFLVDVTPASQHAYGPRLRVGIRYLFRAHASAVRSSVLEAGAAAWVPLSEVSMPPLRGRLESLLIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEG6</accession>
    <name>A0A2G1XEG6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26700</name>
        <name evidence="4" type="ORF">CYQ11_18935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49612">
        <property type="protein sequence ID" value="PHQ49612"/>
        <property type="gene ID" value="BLA24_26700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14668">
        <property type="protein sequence ID" value="PPT14668"/>
        <property type="gene ID" value="CYQ11_18935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="98"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="28045" checksum="CFE617C8D9238452" modified="2018-01-31" version="1">MPGGRLTQRERQQIALGLADELAYAEIARRLDRPTSTITREVMRNGGPTAYRADLAHRATERRTHRRRQAAPQGPQAPAQAHGRDAEALHEYEETFTTLLIQTGLPKMTARVLTCLYTTDAGSLTASELVQRLQVSPASVSKAIALLESQGLVRRERDDRRRERYVVDNDVWYQGMIAAARSHAQLAEIARQGVSVLGRDTPAAVRLENIARFVDFVGERMAHAAEQARDILYTKAETTPAGAAEPGTDQSGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEM4</accession>
    <name>A0A2G1XEM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_23170</name>
        <name evidence="6" type="ORF">CYQ11_22905</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49687">
        <property type="protein sequence ID" value="PHQ49687"/>
        <property type="gene ID" value="BLA24_23170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16736">
        <property type="protein sequence ID" value="PPT16736"/>
        <property type="gene ID" value="CYQ11_22905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="162" mass="17689" checksum="D8BB7B5A0108307F" modified="2018-01-31" version="1">MATRSADPKGVHGTPPTDAVSLAIIEQLQEDGRRPYAAIGKAVGLSEAAVRQRVQKLLDQGVMQIVAVTDPLTVGLRRQAMVGVNVDGDLDPVADALTAMDEVEYVVVTAGSFDLLIEIVCEDDDHLLETINKRIRTLPGVRSTESFVYLKLRKQTYTWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XER0</accession>
    <name>A0A2G1XER0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgB</name>
        <name evidence="12" type="ORF">BLA24_23995</name>
        <name evidence="13" type="ORF">CYQ11_22075</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49710">
        <property type="protein sequence ID" value="PHQ49710"/>
        <property type="gene ID" value="BLA24_23995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16716">
        <property type="protein sequence ID" value="PPT16716"/>
        <property type="gene ID" value="CYQ11_22075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="252"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT16716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="735" mass="82274" checksum="67822083F84F729C" modified="2018-01-31" version="1">MRREARRAEPLDDDARARLLAGAHHDPHALLGAHEAAGGVLFRALRPFARSVAVVAKGLRAELNDEGDGLFARVLPLAEIPADYRLVVTYDDAELEIHDPYRFLPALGDLDLHLIGEGRHEELWRALGARPMTHEGVPGTRFTVWAPNARGVQVVGDFNYWDGTAHPMRSLGGTGVWEVFLPGVGEGALYKYRITRPDGSHTLRADPMARRTEVPPANASIVEASHHVWRDDAWMARRGEPPVHEAPFSVYEVHLPSWRPGLSYRRLAEQLPAYVKDLGFTHVELMPVAEHPFGGSWGYQVTGFYAPTARLGTPDDFRYLVDALHRAGIGVLMDWVPAHFPRDDWALAEFDGRPLYEHQDPLRAAHPDWGTLEFDFGRTEVRNFLVANAVYWCEEFHIDGLRVDAVASMLYLDYSREPGQWSPNEHGGRENLDAVAFLQEMNATVYRRCPGVVTIAEESTAWDGVTRATHHVGPGGFGGLGFGLKWNMGWMHDSLDYMAKEPVHRKYHHGEMTFAMVYAYSENYVLPISHDEVVHGKRSLVSKMPGDWWQQRAGHRAFLGFMWAHPGKQLLFMGQEFAQGAEWSEAHGPDWWLLDPSYSAEPDHRGVRDLVRDLNARYRATPALWQRDTVPEGFEWVVGDAAEDNVLAFVRCDAQRSPLLAVCNFSPVVRHGYRIGVPCGVPVWQEVLNTDAAGYGGGGIGNPDPLKAEPAAWHGRRSSIVPVLPPLATIWLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEU7</accession>
    <name>A0A2G1XEU7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CpaF family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26325</name>
        <name evidence="4" type="ORF">CYQ11_19315</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49750">
        <property type="protein sequence ID" value="PHQ49750"/>
        <property type="gene ID" value="BLA24_26325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14733">
        <property type="protein sequence ID" value="PPT14733"/>
        <property type="gene ID" value="CYQ11_19315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="87"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="442" mass="48470" checksum="121291CEA89B42FC" modified="2018-01-31" version="1">MSLRARITAPQEPADGREPGHLVPVYRAKLLEEIDLAEMSGLAASERRIRLERVLGHIISREGPVLSTAERARLIRRVVDEALGLGVLEPLLEDPSVTEIMVNGPDQVYVERAGRVELVPVRFASNEQLMQTIERIVSTVNRRVDESHPMVDARLPSGERVNVIIPPLALNGATLTIRRFPRVYTLRELIGTGTLDEHMLLLLSALVRAKFNVVVSGPTGAGKTTLLNALSGLIPEGERIITVEDAAELQLQQHHVIRLESRPPNVEGKGRITIRDLVRNSLRMRPDRIIVGEVRGGETLDMLQAMSTGHDGSLATVHANSAEDALMRLRTLASMSEVKIPYEALRDQINSAVDCLVQLARSADGSRRIAEIALLDSRGGWDEGHRLATVCRFEAEPMGADRVVRGRFVHSPLPARAAERLRLANESVPPAFGVAPACGPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEX5</accession>
    <name>A0A2G1XEX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Pyridoxal phosphate-dependent aminotransferase</fullName>
            <ecNumber evidence="2 3">2.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26370</name>
        <name evidence="3" type="ORF">CYQ11_19270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49751">
        <property type="protein sequence ID" value="PHQ49751"/>
        <property type="gene ID" value="BLA24_26370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16670">
        <property type="protein sequence ID" value="PPT16670"/>
        <property type="gene ID" value="CYQ11_19270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="403" mass="44281" checksum="1A736151D2E9F7B4" modified="2018-01-31" version="1">MQVIQSTKLANVCYEIRGPVLEEAMRLEAAGHRILKLNTGNPAIFGFECPPEILEDMLRNVGDAHGYGDAKGLLSARRAVVQHYETRGIELSVEDVYLGNGVSELIQMSMQALLDDGDEVLVPAPDYPLWTASVSLAGGTAVHYRCDEQADWMPDLADIERKVTDRTKAIVIINPNNPTGAVYDDEMLRGLTEIARRHNLIVCSDEIYDKILYDGVTHTPTAALAPDLLTLTFNGLSKAYRVAGYRSGWMAVCGPKAHADSYIEGLTILANMRLCANMPAQYAVATALGGRQSINDLVLPGGRLLEQRDVAHELLTQIPGVSCVKPKGALYAFPRLDPKVYKIKDDRQMVLDLLRAEKIMVVHGTGFNWPEPDHFRLVTLPNAKDLADAVTRIGNFLDGYGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF61</accession>
    <name>A0A2G1XF61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3618 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_19745</name>
        <name evidence="2" type="ORF">CYQ11_11045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49874">
        <property type="protein sequence ID" value="PHQ49874"/>
        <property type="gene ID" value="BLA24_19745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13350">
        <property type="protein sequence ID" value="PPT13350"/>
        <property type="gene ID" value="CYQ11_11045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="119" mass="12884" checksum="A4D5BD0525FD9E31" modified="2018-01-31" version="1">MAEARTPAQIEADIARRRQDLAVVLDEIGVRMHPKTIVGDAKAKVASKVDQTAGRAYVAANRVVSEVRARFVTEDGQPRLERIVPAAMVAVGIVGLLTVRSSKASKASKPVKRSRGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF82</accession>
    <name>A0A2G1XF82_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19895</name>
        <name evidence="5" type="ORF">CYQ11_10895</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49898">
        <property type="protein sequence ID" value="PHQ49898"/>
        <property type="gene ID" value="BLA24_19895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13326">
        <property type="protein sequence ID" value="PPT13326"/>
        <property type="gene ID" value="CYQ11_10895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304844" evidence="3">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="235" mass="23621" checksum="7F7E2C9C106C3C12" modified="2018-01-31" version="1">MASVRFALCGAVAAVAAAAAPVHAHAHDGPATGARAIELAPVAGRPGGEVKLHVSGCAGDRATAVSKAFVSDARLARDPAGLYAEATVRDTVPAGSYPVRVDCDGHSATAHGRLTVVDKASLDDRARDLPGPGPAEDDEPPDGRGYDDASHDESGPGGAYREEPGPGAYDERSDRAPQHHPHGSPFAPVPAGGGGTRPAAAPEAPDTAGLVLAGVTAAIAGALIWHRRRTGSAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFH5</accession>
    <name>A0A2G1XFH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">TQXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20500</name>
        <name evidence="9" type="ORF">CYQ11_10280</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49994">
        <property type="protein sequence ID" value="PHQ49994"/>
        <property type="gene ID" value="BLA24_20500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13228">
        <property type="protein sequence ID" value="PPT13228"/>
        <property type="gene ID" value="CYQ11_10280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004629">
        <property type="term" value="F:phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304653" evidence="6">
        <location>
            <begin position="36"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="471" mass="46961" checksum="1A9BD23017FFFB06" modified="2018-01-31" version="1">MNSVKRRGAARLAAAVLASGLAVAGTVAGAGSAAADDAPHNQGGVTATLGKITAGGGAVVHDRRKTGPVMAGLFEMKVDGGGTLQTYCIDILTNTVDGAKYKETGWGESSLHDNKNAGRIRWILQHSYPQINDLAALSKDSGAGVLDANTAATGTQVAIWRYSDNVNVEAKNPAAEKLADYLYESAKDVEEPKASLTLTPPAVSGKPGQRIGPVTVHTNAGSVAVAPSGDAVAKNVKVVDEAGKPVITTADGGRLFFDVPAGAPDGSVSFKASAATKVPVGRAFIGDHTKTQTMILAGSSESTVFATATANWASKGAIPALTAKKDCAKGGVEITAENKGDQPFVFELDGKTHTVQPGGSETTLVKVGEDQAYKITITGPNGFSKTFSGILDCKTAEGGSAGGAGGGAGGAGTPSASPSPATGGVATTGSTTGGDLASTGSSSTTPVIAGVAIALIVAGSGAVYLLRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG01</accession>
    <name>A0A2G1XG01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Magnesium transporter MgtC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_21585</name>
        <name evidence="9" type="ORF">CYQ11_09200</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50170">
        <property type="protein sequence ID" value="PHQ50170"/>
        <property type="gene ID" value="BLA24_21585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13047">
        <property type="protein sequence ID" value="PPT13047"/>
        <property type="gene ID" value="CYQ11_09200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="28435" checksum="B57B33F687EF6378" modified="2018-01-31" version="1">MDIVELLTGPFISAGRVHAAPLFDPGNGQGARQYAELAMALLLSSLIGMERELQQKSAGLRTHTLVGVGSALFMEVSIHGFGALSGVADARLDGSRVAAQIVSGIGFIGGGLIFVRRDAVRGLTTAATIWLTCAIGMACGGGLPLLGVAAALVHFLVVRGFPLVTRRLPAAPSTTHRVELRLFYRTRRGLLARVLELCTQRGFRVTDVRIDARPSSEENPERGRGKVKEAGLVLGLEGKGSAHPLVEELTDWDGILGVGLRSHRDSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG15</accession>
    <name>A0A2G1XG15_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">BLA24_21615</name>
        <name evidence="12" type="ORF">CYQ11_09170</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50176">
        <property type="protein sequence ID" value="PHQ50176"/>
        <property type="gene ID" value="BLA24_21615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13041">
        <property type="protein sequence ID" value="PPT13041"/>
        <property type="gene ID" value="CYQ11_09170"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="243"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="334" mass="35026" checksum="6CAB59C176683C6D" modified="2018-01-31" version="1">MTATIKPAKGAPYARIMGVGGYRPTRVVPNEEILKHIDSSDEWIRSRSGIATRHWAGPEETVAAMSVEAAGKAIADAGITPEQVGAVIVSTVSHFKQTPAIATEIAHRIGAGKPAAFDISAGCAGFGYGLTLAKDMVTGGSAEYALVIGVERLSDLTDLKDRATAFLFGDGAGAVVVGPSNQPAIGPIVWGSEGDKAETIKQTVAWDVYREETDVRFPAITQEGQAVFRWAVFEMAKIAQQALDEAGVHPDDLDVFIPHQANMRIIDSMVKTLKLPENVTVARDVETTGNTSAASIPLAMERLLATGAAKSGDTALLIGFGAGLVYAATVVTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGB3</accession>
    <name>A0A2G1XGB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Site-2 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_22260</name>
        <name evidence="16" type="ORF">CYQ11_08525</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50280">
        <property type="protein sequence ID" value="PHQ50280"/>
        <property type="gene ID" value="BLA24_22260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12934">
        <property type="protein sequence ID" value="PPT12934"/>
        <property type="gene ID" value="CYQ11_08525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ50280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="269" mass="29437" checksum="C81B613A334340F6" modified="2018-01-31" version="1">MASTATRGERRVSPVFLALVAIMAVSLWAVWTGFSASPGFAVFLFILSGWIVSLCLHEYSHARTALHGGDISVGAKGYLTLNPLLYTHAVLSIVLPVVFVVMGGIGLPGGAVFIEQHRIRSRWKQSLVSAAGPLMDAVFALAVGLPFLLGALDGAPDNVRYALAFMIQLHVTAVILNFLPVPGLDGFGVIQPWLSYKVRRQVEPFAPFGLLAVFGFLWIPEVNHAFFDMIDAVLRTLGVTEWDTYWGQELFRFWQGTPEIPPLHTVDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGC5</accession>
    <name>A0A2G1XGC5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_22295</name>
        <name evidence="5" type="ORF">CYQ11_08490</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50286">
        <property type="protein sequence ID" value="PHQ50286"/>
        <property type="gene ID" value="BLA24_22295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12928">
        <property type="protein sequence ID" value="PPT12928"/>
        <property type="gene ID" value="CYQ11_08490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="347" mass="36697" checksum="BDDE54867EC1349E" modified="2018-01-31" version="1">MPQAYVEETGREGAGPERTGSGAPTFPGRWRGLGAWLGKWKGPGLWRRGLVLAVLAALLGLLMLLHTHLPNRVGNLGSLTETFLPWLGLFVPVLLVLALVRRSATALIALLLPAVAWVNLFGGLLSDKTGKGGDFTVATHNVNAGNPDPAATAKAVAASGADVVALEELSDASRYERAMAGTYRYHSVQGTVGVWSRYPLSDARPVDIKMGWTRALRATVHAPKGPVAVYVAHLPSVRVKFNAGFTAGQRDNSAEALGQAISHEPVKKVVLLGDLNGTMNDRSLAPVTSQLRSAQGAAGNGFGFTWPAGFPMARIDQIMVRGLDPVSAWTLPATDSDHLPVAARVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGL2</accession>
    <name>A0A2G1XGL2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_22630</name>
        <name evidence="12" type="ORF">CYQ11_08160</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50341">
        <property type="protein sequence ID" value="PHQ50341"/>
        <property type="gene ID" value="BLA24_22630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12870">
        <property type="protein sequence ID" value="PPT12870"/>
        <property type="gene ID" value="CYQ11_08160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="348" mass="35733" checksum="E5BEB564B434C415" modified="2018-01-31" version="1">MSGLNLDDFATLIERPDSGVRRDAEERRERIGPRPGALGRLDELGEWLAAAQGAVPVKPVTRPKAVLFAGDHGVAELGVSGGPAEGARTLVRAALDGLGTGAILARRAGVELRVVDMSLDCDPADLPGDVTRHRVRRGSGRIDVEDALTAEEAERAFRAGMAVADEEADSGTDLVVLGDLSVGGTTAAGVLIAALCGTDASVVTGRGGFGIDDLAWMRKCAAIRDALRRARPVLGDQLQLLAAVGGADLAAMTGFLLQSAVRRTPVILDGVVCAAAALVGQRVAFRAPDWWLAGQAAGDPAQAKALDRMALNPLLDHGVTVGEGTGALLALPLVQAAAALAAELPEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGL6</accession>
    <name>A0A2G1XGL6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20390</name>
        <name evidence="2" type="ORF">CYQ11_10395</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50380">
        <property type="protein sequence ID" value="PHQ50380"/>
        <property type="gene ID" value="BLA24_20390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16471">
        <property type="protein sequence ID" value="PPT16471"/>
        <property type="gene ID" value="CYQ11_10395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="329" mass="35902" checksum="39BE9AC1BD9E613A" modified="2018-01-31" version="1">MAARRAKAFALTANQGNLTGEVMEQIHEDVRQLATDYPQRPLSELLGDLVQTQETLYTLLDSRQRPEQARQLYFLTGVTSGLLAKASHDLADPHAAMTQARAAYLCAENADHNGLRAWIRGLQALIAYWAGRLHESVKYAQSGAEFAALSHSTTSVWLPISEARAWAALGNVNQTHAAIRRAEDAWNEVRSDEVDELGGLCSFGRTRQIYYAADALAWLPSEAGTAQDYAAQAVDVYADTSGPEWAFGDAAGSRADLAIARIHLGQLEGADEAVSPILELAPENRINGIINSAMRVHKALSRSPLAPSGSELQERIEMFTRTPLRSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGN9</accession>
    <name>A0A2G1XGN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20920</name>
        <name evidence="4" type="ORF">CYQ11_09860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50392">
        <property type="protein sequence ID" value="PHQ50392"/>
        <property type="gene ID" value="BLA24_20920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16461">
        <property type="protein sequence ID" value="PPT16461"/>
        <property type="gene ID" value="CYQ11_09860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043857">
        <property type="entry name" value="DUF5819"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19136">
        <property type="entry name" value="DUF5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="202" mass="22657" checksum="0F91D07DBB78344B" modified="2018-01-31" version="1">MSRPAGLVIAFAAAVCVATVMVHVCMVFLSVAPPNTVSQRYEGRISTWVYPYFEQNWRLFAPDPEGARRRVLARTATMAPDGARQVSGWIDLSAVDASAVRHNAFPSHINQNMLRRAWSAYLDSHGTRDQSESDRARIIQRYLLNIAAQRAARSHRSFDAIQLRVITTPIASPARRADGSRSPQPPSDSRYLPWWQVTSHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGP5</accession>
    <name>A0A2G1XGP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21465</name>
        <name evidence="3" type="ORF">CYQ11_09320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50410">
        <property type="protein sequence ID" value="PHQ50410"/>
        <property type="gene ID" value="BLA24_21465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16445">
        <property type="protein sequence ID" value="PPT16445"/>
        <property type="gene ID" value="CYQ11_09320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="31059" checksum="C2E224077DDE1EE3" modified="2018-01-31" version="1">MAAAVPKGAGGHGREGSWSSEEARRFWGPSRMSEATEAPADDANADPQIEAQRITGSARHFAGVPSVGVLFYVGDDMRNHFCTASVVHSPKGNMIITAGHCSHGDEAAFVPDYRQGSGKQPFGVWAVDREFVDPRRDSTGEDSDLDFAFATVKPDGRGRQIERVTGANRLVRTPGYTNRTTVIGYPSSDADAADQAIRCTAMTTRLEGYKQLQMRCDGFYSGTSGSPWLIRFDERTKTGDLIGVLGGLNGGGPDGDESDKVSYSPINDDEIFKLYLDAINNREPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGV5</accession>
    <name>A0A2G1XGV5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">tilS</name>
        <name evidence="9" type="ORF">BLA24_16590</name>
        <name evidence="10" type="ORF">CYQ11_16695</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50462">
        <property type="protein sequence ID" value="PHQ50462"/>
        <property type="gene ID" value="BLA24_16590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14283">
        <property type="protein sequence ID" value="PPT14283"/>
        <property type="gene ID" value="CYQ11_16695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="40"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="8">
        <location>
            <begin position="267"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="339" mass="35518" checksum="C86C144C52662BFC" modified="2018-01-31" version="1">MGPHPAVAAIRLAVRRVLHDVLTLAPPASVPQAAGDRPLVLAACSGGADSMALASALAFEAPRLGIRAGGVTVDHGLQEGSDLRAAEVVSRLAAFDLDPVEAVKVSVGREGGPEAAARDARYAALDAVAERHGAAAILLGHTRDDQAETVLLGLARGSGIRSLSGMAVASGVGGRYRRPFLELDRQTARKACMVQSLPVWDDPHNADPAYTRSRVRHEALPVLEKALGKGVVEALARTAQLSRDDADALDSWAAAVEPSVRDDSGALEVAKLFALPPAVRRRVLRRAAIAAGSPAGSLFARHLEEVDRLITSWRGQGAINLPGRVAVRRQGGRLVLRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH68</accession>
    <name>A0A2G1XH68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_17340</name>
        <name evidence="12" type="ORF">CYQ11_15935</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GtrA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50576">
        <property type="protein sequence ID" value="PHQ50576"/>
        <property type="gene ID" value="BLA24_17340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14170">
        <property type="protein sequence ID" value="PPT14170"/>
        <property type="gene ID" value="CYQ11_15935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="9">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="10">
        <location>
            <begin position="293"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="421" mass="45297" checksum="39A1A3568A29DF3A" modified="2018-01-31" version="1">MPQTTRRTAPPSPLPARGPLPRDGTVVLDVVIPVHNEEEDLEACVRRLHAHLADTFPYRFRITIADNASTDRTPEVAALLDDAIEEVTAVRLERKGRGQALHTVWTLSEAPVLAYMDVDLSTGLNALLPLVAPLISGHSDLAIGSRLTGGSRVVRGPKREFVSRAYNLILRTGLAARFSDAQCGFKAIRKDVAERLLPLVEDTGWFFDTELLVLAERAGLRIHEVPVDWVDDPDSSVHLVRTATDDLRGVWRVGRALATGRLPLDRLARPFGDDPRDHALDVPRGLARQLLGFLVVGALSTLAYLGLYWLLRTGAGAGPQPANAAALLVTTVGNTAANRRLTFGVRGRGRVLRHQAQGLVVLGIGLALTSGSLAALDLAGGSPGHGAELSVLVAANLAATALRFLLLRAWVFPHHSQGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHD3</accession>
    <name>A0A2G1XHD3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BLA24_17755</name>
        <name evidence="21" type="ORF">CYQ11_15520</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50642">
        <property type="protein sequence ID" value="PHQ50642"/>
        <property type="gene ID" value="BLA24_17755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14103">
        <property type="protein sequence ID" value="PPT14103"/>
        <property type="gene ID" value="CYQ11_15520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLOBIN" evidence="18">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="317"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PHQ50642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PPT14103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="553" mass="59719" checksum="97B87DEE4F7EDB75" modified="2018-01-31" version="1">MNAPTTPPAGGGTSGERGAWGWFAPSDGEGPKRPARQAPTGSGAESADESPEPPPPPGCRWRPLAYERGPYEPQDHPGQYGLQDHPGQHGLQDHPGQEGLQTHTSQHGQQDHPGQYAQPGHPHQGEQREHQRAPEPPDGPPHSPPGGRPAARPQGGWEAPAGPACEAPDRRPASPATPSPDTLLIRRTLAEIEPIADKVTSYFYALLFLQAPGLRALFPAAMDTQRDRLFKALLTAARHADDTATLSAYLSDLGRSHRKYGTEAAHYPAVGESLIGALSRHATATWCEETQAAWVRAYTAISQIMIDAAAEDERTSPAWWHAEIVSHESRTQDVAVVTVRPDQPYPFVAGQYAAVETPWWPRVWRNYSFSCAPRDDGLLSFHIKAVPAGWVSRALVHRAGLGDVIRLGPPNGSMTVDHTTDNGMLCLGGGTGIAPIKALVEDVARHGRSRPVEVFYGARHDDDLYDIDTMLRLQKAHAWLSVRPVVSHGPTLGLSGQLPQVIRKYGPWTAFDAFLSGPPGMIRSGVDTLVGIGIPSHRIRHDSIDDLTASATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHD7</accession>
    <name>A0A2G1XHD7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17775</name>
        <name evidence="3" type="ORF">CYQ11_15500</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50645">
        <property type="protein sequence ID" value="PHQ50645"/>
        <property type="gene ID" value="BLA24_17775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14100">
        <property type="protein sequence ID" value="PPT14100"/>
        <property type="gene ID" value="CYQ11_15500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="150" mass="16496" checksum="4EB78B13E9953B54" modified="2018-01-31" version="1">MSDIEIRRATADDLPAIVALLADDALGAQRESPDDLAPYRAAFDRLDGDPHQYLAVAVRDGRTVGTLQLTVVPGLSRRGASRSVIEGVRVHADERGSGLGTELIQWAVDRSRNEGCRLVQLTSDATRVDAHRFYERLGFEASHLGFKYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHF7</accession>
    <name>A0A2G1XHF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17870</name>
        <name evidence="3" type="ORF">CYQ11_15405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50662">
        <property type="protein sequence ID" value="PHQ50662"/>
        <property type="gene ID" value="BLA24_17870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14083">
        <property type="protein sequence ID" value="PPT14083"/>
        <property type="gene ID" value="CYQ11_15405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="423" mass="44009" checksum="AA4E832A8400CB84" modified="2018-01-31" version="1">MPVVRDLRVLLHLRDFRRLLTVRLLSQAADGVYQVALATFVVFSPEKQASPAAIASAMAVLLLPYSLLGPFAGVLLDRWRRRQVLLHGNLLRAALATATALLVVARCPEWLFYASALSVTAVNRFVLAGLSAALPHVVDSPERLVMANSVSPTAGTLAATAGGGLAFAVRLGVPEGTAASDAWAMLLGAALYLGAALCSLRMPAGLLGPDAPGPAARVRTALATTVRGMADGLRHLAERPVAARALAAMTLMRFCYGALTVMLLMLCRHSWADDDKGGLAMLGYAVAASGAGYFAAALSTPWAVGRLGWLGWMTACAATAAVLEPALGLPFEPAPMLVAAFVLGVTTQGAKITTDTVVQATVDDAFRGRVFSLYDVLFNVAFVGAAGTAALMLPPDGRSAVLVVTISVIYAGITAGLALFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHH1</accession>
    <name>A0A2G1XHH1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_18020</name>
        <name evidence="8" type="ORF">CYQ11_15255</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50688">
        <property type="protein sequence ID" value="PHQ50688"/>
        <property type="gene ID" value="BLA24_18020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14057">
        <property type="protein sequence ID" value="PPT14057"/>
        <property type="gene ID" value="CYQ11_15255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="378" mass="40682" checksum="67F319B6FC0D587F" modified="2018-01-31" version="1">MGEVFAGRYELVDPIGRGGAGAVWRAWDRRRRRYVAAKVLQQSDAHTLLRFVREQALRIDHPHVLAPMSWAADDDKVLFTMEMVGGGSLAHLIGDYGPLPPHFVCVLLDQLLSGLTAVHAEGVVHRDIKPANLLLEATGTGRPHLRLSDFGIAMRKGEPRLTDTNFVMGTPGYFAPEQLLGEEPDFPADLFAVGLVALYLLTGRKPDAEALVERFLAQGVPSAPAEVPEPLWDVVANLLHPDPYTRFRTATGARKALAAAVELLGEPAADEERIEVFDQLGPLPPGFGPDGPQRRPGAQAEPRPQPPAPPRPNYPPTRLYTPPQTPARHLSGPPPPAPPPAPVTAPRGRPSPPAKVAVPVLLLALLCLAVGVWALAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHJ0</accession>
    <name>A0A2G1XHJ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminodeoxychorismate/anthranilate synthase component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18070</name>
        <name evidence="3" type="ORF">CYQ11_15205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50696">
        <property type="protein sequence ID" value="PHQ50696"/>
        <property type="gene ID" value="BLA24_18070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14049">
        <property type="protein sequence ID" value="PPT14049"/>
        <property type="gene ID" value="CYQ11_15205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="212" mass="22802" checksum="D0517602E4E9B9ED" modified="2018-01-31" version="1">MSARILVVDNYDSFVFNLVQYLYQLGAECEVRRNDEVEPAHAQDGFDGVLLSPGPGAPEQAGVCIDMVRHCAKTSVPVFGVCLGMQSMAVAYGGVVDRAPELLHGKTSPVTHEGKGVFQGLPSPFTATRYHSLAVERDSWPDELEITAWTDTGVAMGLRHRDLPVEGVQFHPESVLTEWGHRMLANWLVACGDMGAVERSAGLAPVVGKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI07</accession>
    <name>A0A2G1XI07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16520</name>
        <name evidence="4" type="ORF">CYQ11_16765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50857">
        <property type="protein sequence ID" value="PHQ50857"/>
        <property type="gene ID" value="BLA24_16520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14296">
        <property type="protein sequence ID" value="PPT14296"/>
        <property type="gene ID" value="CYQ11_16765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="2">
        <location>
            <begin position="49"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="34477" checksum="C17C342F2EC30B46" modified="2018-01-31" version="1">MTRSTRRARTPRALLAVAGVGVLTAGLSACGGDSLEKSGGRADGGGKGSLVVGSASFTESKVLAEIYAALLRDAGYSTSIKTVDARELYEPAMERGEIDVVPEYAATLAEFLNKHQNGKDAPPVASADADTTVKALRKLAEPRGLKVLDPGRAVDQNAFAVTSDFATEHQLKTLSDLGKSKVGVKLAAGDECSQRPFCRPGLEKTYGIDVTGLDPLEVGSPQAKQAVKDGKDQLLLTTTTDATLEQFGLVLLKDDKDLQNSDNVLPVVNAKKAGTEEIAYALGKLNRVLTTADLTELNKKVDAERLKPADVAARYLKQKRLVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI12</accession>
    <name>A0A2G1XI12_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage holin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16860</name>
        <name evidence="4" type="ORF">CYQ11_16425</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50865">
        <property type="protein sequence ID" value="PHQ50865"/>
        <property type="gene ID" value="BLA24_16860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14243">
        <property type="protein sequence ID" value="PPT14243"/>
        <property type="gene ID" value="CYQ11_16425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="152" mass="15432" checksum="04720C7FB52C81A5" modified="2018-01-31" version="1">MSAADDGANRSLGQLMATATTELSALVHDEIALAKAELREDARRLGIGGGAIAGAGVLALFSLPVLSFAAAYGIHNLGLGLAWSFLITGGAFLLLAALLGLLAVTKFKKIKKPEKSIASAKETAAVLGTVKPHPRPVVGTSQADASVTRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI36</accession>
    <name>A0A2G1XI36_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">BLA24_18710</name>
        <name evidence="7" type="ORF">CYQ11_14570</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50914">
        <property type="protein sequence ID" value="PHQ50914"/>
        <property type="gene ID" value="BLA24_18710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16561">
        <property type="protein sequence ID" value="PPT16561"/>
        <property type="gene ID" value="CYQ11_14570"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="18712" checksum="8B4D92B9C95DA5BD" modified="2018-01-31" version="1">MTDARDALLQQIKDKAVVHGKVTLSSGKEADYYIDLRRITLDAEAAPLVGQVMLDATADLAFDAVGGLTLGADPVATSMLHAAAARGRKLDAFVVRKAQKTHGMQRRIEGPDIKGRRVLVVEDTSTTGGSPLTAVEAAREAGAEVVAVATIVDRGAEQAIQDAGLRYVTGYSLGDLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI38</accession>
    <name>A0A2G1XI38_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18555</name>
        <name evidence="4" type="ORF">CYQ11_14725</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50908">
        <property type="protein sequence ID" value="PHQ50908"/>
        <property type="gene ID" value="BLA24_18555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16567">
        <property type="protein sequence ID" value="PPT16567"/>
        <property type="gene ID" value="CYQ11_14725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="607" mass="63425" checksum="87F23CFA1FFDDADA" modified="2018-01-31" version="1">MRLHGEYQGSGFTEPKYIARRGDGQVVQLSRLLHLVASAVDGTRDMRAVAREVSAGFGREVSGENVAYLVENKLEPLGVTVPPGQESDEVQGPRSDLLLGLKGHRVIFNERRVAVIARSLAWLHRPPVVAGVLALAVAMDVWLFGFHGAMTPVLNVLDQPLLLLVVFGITVASLVFHEFGHASACRYDGAHPGCIGCGIFLIWPSMYTDVTDVYRIGRAGRLRTDLGGVYFNVVFMLLLTGAYFVTGQPFLLCAVYLGHFEVLEQLMPAVRLDGYFILGDLAGVPDLYGKIKPILLSMVPGRRTDPAVADLKRRTRVVVTTWVVTMVPLLAAELAYALWNLPRLVATGVRSLAQQLVGTYEAFADGEVLSGLAGVLGSLMLICPLAGMTYLSIRLSGRLGRNALRATAGRPRLRIGLLLGVAAVATTLGFAWSSGVTPKPLPPKPPLAPILQPHVPTLPPPEPAHPELPGRDPARSQVPGVWSPGGSVPAVSPLPWRTPPPRPGMPTPAPAVTAGPPAAPAGGPAAAPGPKPTTAPAPVVLPPAGPPAKPPVLPPSTPKPEPATTTSAPSPAPATPPAATPPATTAPPAATTAPAPTAPPASPAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIF3</accession>
    <name>A0A2G1XIF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_14455</name>
        <name evidence="5" type="ORF">CYQ11_13620</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50990">
        <property type="protein sequence ID" value="PHQ50990"/>
        <property type="gene ID" value="BLA24_14455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13788">
        <property type="protein sequence ID" value="PPT13788"/>
        <property type="gene ID" value="CYQ11_13620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="36"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="445" mass="48042" checksum="A77A63E541863418" modified="2018-01-31" version="1">MAIDYGSHAPEAPRSHKVPAVLRAPLEGRTWREFLYLLLGMPIAVCTFAYAVTLTAAGVGLLITFLGVPLLAATLVGARGLGVLERARARALLRLEVAEPEPVRTRSRDGRAGLMAWVGAVLKSGTSWRHLLYMVLYLPWALFAFVVSLVLWSVSWTVFLYPLWKWVLPTYGDQPGIQLYGDDDGRTWYLDSPFEVGAASALGLVLVLGTPWVIRGLTQVDRLLVSGLLGPSRLAERMWELEEDRGVVVDTAAADLRRIERDLHDGAQARLVALAMDLGLAKEKLLEDPDAAAKMVDEAHGEVKLALQELRDLARGIHPAILTDRGLGPALSALAARCTVPVTTEVDLPTRPAAAIEGIAYFTVSELLQNISKHSQARTARVDVWRVDSRLMLQVGDDGHGGASTAGGSGLAGLAERLRSVDGLLVVDSPQGGPTTVTAELPWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIF8</accession>
    <name>A0A2G1XIF8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="8" type="ORF">BLA24_14735</name>
        <name evidence="9" type="ORF">CYQ11_13335</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004950443.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51034">
        <property type="protein sequence ID" value="PHQ51034"/>
        <property type="gene ID" value="BLA24_14735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13743">
        <property type="protein sequence ID" value="PPT13743"/>
        <property type="gene ID" value="CYQ11_13335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="10471" checksum="4A5E555720572ECA" modified="2018-01-31" version="1">MPRSLKKGPFVDGHLIKKVDAQNEAGTKNVIKTWSRRSMIVPAMLGHTLAVHNGKTHVPVFVTESMVGHKLGEFSPTRTFRGHVKDDRKSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIK2</accession>
    <name>A0A2G1XIK2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">BLA24_14835</name>
        <name evidence="7" type="ORF">CYQ11_13235</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956441.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XIK2"/>
    <dbReference type="EnsemblBacteria" id="PHQ51053">
        <property type="protein sequence ID" value="PHQ51053"/>
        <property type="gene ID" value="BLA24_14835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13724">
        <property type="protein sequence ID" value="PPT13724"/>
        <property type="gene ID" value="CYQ11_13235"/>
    </dbReference>
    <dbReference type="GeneID" id="58435565"/>
    <dbReference type="GeneID" id="63982148"/>
    <dbReference type="GeneID" id="66955264"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="37" mass="4389" checksum="349DC4355BFEF0C8" modified="2018-01-31" version="1">MKVKPSVKKICDKCKVIRRHGRVMVICDNLRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIL6</accession>
    <name>A0A2G1XIL6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF389 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14900</name>
        <name evidence="3" type="ORF">CYQ11_13170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51065">
        <property type="protein sequence ID" value="PHQ51065"/>
        <property type="gene ID" value="BLA24_14900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13712">
        <property type="protein sequence ID" value="PPT13712"/>
        <property type="gene ID" value="CYQ11_13170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="32642" checksum="52E5E73479A08C12" modified="2018-01-31" version="1">MLHLRIISPADRTDEIVALAERTVGVAHLAVLTGAARSPQGDIVLCDVAREAADELLEALGEAGVPQWGAIAVDGVDLMLSRRAEVAKEEAPGEGADAIVWESLAGETHEESTLTVTFLAFLTVATMLAACGVIIDSAILIVGAMAVGPEFGPLAGLCTALVRRTPRLAWRSLAALLVGFPVAMLVTGGFSLLMDWLGLFHEAKFLAPRPQTAFIWQPDAFSFIVAFLAGIAGILSLTSAKSGALIGVAISVTTVPAAANAAVALSYGNWSETRGSAVQLALNLLGIVIAGTLTLLAQKWFWARQRARGPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIQ8</accession>
    <name>A0A2G1XIQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15310</name>
        <name evidence="3" type="ORF">CYQ11_12760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51138">
        <property type="protein sequence ID" value="PHQ51138"/>
        <property type="gene ID" value="BLA24_15310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13640">
        <property type="protein sequence ID" value="PPT13640"/>
        <property type="gene ID" value="CYQ11_12760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="70" mass="7468" checksum="E5FAEE84B79F3943" modified="2018-01-31" version="1">MSGPTRIVVHPPTPSGGRWVTDGAETLGIAHGIADVIEFLTRDGVDLRDAELDDPDLIEWQGGGPGHWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIR8</accession>
    <name>A0A2G1XIR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_15185</name>
        <name evidence="7" type="ORF">CYQ11_12885</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51115">
        <property type="protein sequence ID" value="PHQ51115"/>
        <property type="gene ID" value="BLA24_15185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13662">
        <property type="protein sequence ID" value="PPT13662"/>
        <property type="gene ID" value="CYQ11_12885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="256"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="41757" checksum="9B1D01DA5F755DD8" modified="2018-01-31" version="1">MDAAFSEEQAGIRAALRELLLKRCGVAEVRAAVLTPAGHDEGLWRQLAERLGLAGLAVEQRYGGVGCGPTELALAGEETGRALLPSPLLATTALATPLIASLGTTEQRAELLPRLASGELTAALALPGAPLPVALGLVGPEGAAPPVGGRAGGVQARRTPDGWRLYGEAGQVLDGHSAGLLIVAAHTGGYVDGRALLFLVRPAEARGVVRARLTVMDETRPQARVQLRDVRAELLGARERDAWGVLAALGGPVAAVLAAEAVGVADAALERTVGYARVREQFGRPIGSFQAVKHRLADLHVAVQGARSAAYYAAWAAGGGQPPSGAAAVGGLALAQALETAWTVTGEAIQLHGGIGVTWEHDVQLYFKRAASDALLFGPVHRLRARAAEAAGLFAVTDEREAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIZ8</accession>
    <name>A0A2G1XIZ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_15825</name>
        <name evidence="9" type="ORF">CYQ11_12250</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51222">
        <property type="protein sequence ID" value="PHQ51222"/>
        <property type="gene ID" value="BLA24_15825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13554">
        <property type="protein sequence ID" value="PPT13554"/>
        <property type="gene ID" value="CYQ11_12250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="292"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="750"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="846" mass="86670" checksum="52449CEE724E3F67" modified="2018-01-31" version="1">MTGRLALRSLRHRMGGFLATFVALFIGATVVMACGGLMETGIRNNVPPQRLAGAQLIVTGDRTFVRPGDKHKEVVLPERVELPAALTDKVRAVPGVRTAVGERSFDAALTDRGGKAVGHAWDSAALTPYALDTGGGAPAGAGEVVLDAQLARRAGAGVGDTVRIAAHGGSAAYRVSGVARPTAGRDVPQPALFFSAAEARRLSAREDTVADIAVVLAPGADRGAVREGVAAALAGHRVSLLTGDDRGTVEHPETLAGGEDLVALSGVFGGLAVSIAIFVVAGTVGLCAQQRRRELALLRAIGASAGQLRRMLLGETLIVAVLAGAAAWPAGPVLGRWLFGRLTGSGLTADTVEFSQGWIPAMPAYGSMLLTAVLGGLLGTSAAVRARPVEALCEAAVPRRGLHPVRIVLGLLFLAGATALALVSLLVLRGPVAASTAGPTVMCCATGFALLGPWFATPVTALLHWPVRLLTGPAGRLAALNCRATAARTAAVATPVMLATAVTTGMLYLQTSVAAATERAFTEDLRADAVLTSVTGGVSPSLADAVRRLPGVAGASASVTGSAYTERPHDGDEAKRGLPLTGVDADGARQTLATRVTAGSLTALQGDTLALPEHVAHRMHRGVGDTVRLRLGDGTAVDVRVVALTTGREGFESALTSVGMLAPHTTAGLPDRILVRAAAGTGRDRLLRELAAFVERHPGVKVTDRDALTAQHARNTRTQAWANYLIVGVLVAYTALSVVNSTAVSVGNRRRDFALQRLTGATRAQVLRMMTVEGTLVALVGLVLGTAAAATTLVPFNLAVADTPLPSGPPSIYAAVAGGAWALTLAATLVPTWAVLRTRPVEAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ12</accession>
    <name>A0A2G1XJ12_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6299 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15785</name>
        <name evidence="4" type="ORF">CYQ11_12290</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51215">
        <property type="protein sequence ID" value="PHQ51215"/>
        <property type="gene ID" value="BLA24_15785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13561">
        <property type="protein sequence ID" value="PPT13561"/>
        <property type="gene ID" value="CYQ11_12290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046266">
        <property type="entry name" value="DUF6299"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19816">
        <property type="entry name" value="DUF6299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304956" description="DUF6299 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6299" evidence="2">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="15068" checksum="157C729EE5CA1C52" modified="2018-01-31" version="1">MRIKDALGAAATAAALTAATVALAPGAAGVPGNALTLDQTGAIDHDGTITLTGTYRCAVPRGSGTVFIGSNVVANGRSDGIGGSTATCDGRTHRWRNTARPHEVTYRPGPVRADAVLMQIRRDRGGIPLPRFLSVAGVRTITLVARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ23</accession>
    <name>A0A2G1XJ23_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_15840</name>
        <name evidence="7" type="ORF">CYQ11_12235</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51225">
        <property type="protein sequence ID" value="PHQ51225"/>
        <property type="gene ID" value="BLA24_15840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13551">
        <property type="protein sequence ID" value="PPT13551"/>
        <property type="gene ID" value="CYQ11_12235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="243" mass="24739" checksum="3E2040FD9DB3C0D2" modified="2018-01-31" version="1">MGVRLMVVDDHRLLAEALASALKLRGHRVLAAAAPSAGAAELVISRAPEVCLLGTAAPAEPGAFDPVVRIKRERPQVAVVVLGPVPSPLGIAAAFAAGASGYVRHNERIEGVERAMMKARAGEAAVDPQLLQGSFAELLNPAAQPDDEGARLLQLLTPREVEVLVRVAEGEDTRLIAAGMGIAPSTARTHVQRVLMKLGVGSRLEAAALAARTGLLDRATGATAARPAVGPQAGPAGAVPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJG9</accession>
    <name>A0A2G1XJG9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16230</name>
        <name evidence="6" type="ORF">CYQ11_11845</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51375">
        <property type="protein sequence ID" value="PHQ51375"/>
        <property type="gene ID" value="BLA24_16230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13485">
        <property type="protein sequence ID" value="PPT13485"/>
        <property type="gene ID" value="CYQ11_11845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="181" mass="19864" checksum="A2DCFD56945AF89E" modified="2018-01-31" version="1">MTTQDRSPEAIAGKPTSASRTTLSHIMTGSDTNLLGTVHGGVIMKLVDDVAGAVAGRHSGGPAVTASMDEMAFLEPVRVGDLVHVKAQVNWTGRSSMEVGVRVLAERWNESTPAVQVGSAYLVFAAVDEHGKPRRVPQVLPETEKDRQRYQEAMIRRTHRLARRRAIMELREKRTPEGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL4</accession>
    <name>A0A2G1XJL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">BLA24_13925</name>
        <name evidence="10" type="ORF">CYQ11_01620</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51425">
        <property type="protein sequence ID" value="PHQ51425"/>
        <property type="gene ID" value="BLA24_13925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11766">
        <property type="protein sequence ID" value="PPT11766"/>
        <property type="gene ID" value="CYQ11_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="383"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="624" mass="68546" checksum="02844D88BB685DB8" modified="2018-01-31" version="1">MCGITGWVDFSRDLTTGSSAPVLDAMTDTLAARGPDARGTWLDTHAALGHRRLAIIDLEHGAQPMCTPEHGPGGLPRAVISYGGEIYNFRELREELVLLGHRFTTRSDTEVALRAYLQWGDDFARRLNGMYSIAVWDTAREELLLVRDRLGVKPLFYHPTADGVLFGSEPKAILANPLARAEAGAEELCDALLFLRSPGRVPFRGMSELKPGHLLKVRRDGITEERYWTLESRPHTDDLKTTVATVRELLDDIVPRQMVADVPLVSLLSGGLDSSTVTALAARARAADGGSLSTFSVDFTGHTENFRADAIRPTPDGPYALEVARHVGSDHHPIVLDRAGLLDPAVRRTVLGAWDLPFNFADLDVSLYLLFAAVREHATVALSGEGADEVFGGYLWFSDPGARSAETFPWLKLGAHRGLDPRSLFHPWFVDGIDLGEYEADLYRTALAEVPLLDGEGAEDRRTRELGYLTLTRWLPILLDKKDRMGMASGLEGRVPFCDHRLVEYVFNIPWDMKTYTGQEKALLRAAAADLLPESVLRRTKAAYPSIQDPAYDQALITGLTAAAGDGDAPLSPFLDADAVRRMTDKTATGSLSEFERILVESTVRLDDWTRTYQVALTGVKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJR1</accession>
    <name>A0A2G1XJR1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51466">
        <property type="protein sequence ID" value="PHQ51466"/>
        <property type="gene ID" value="BLA24_13195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="62" mass="6362" checksum="44DC628D03CC8E07" modified="2018-01-31" version="1">MCGGRSTGPAHPAAAPGGRAQPRPARWEPDKFTAAGFRVQPSQVVRPPRVAGCPIQLDGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJR5</accession>
    <name>A0A2G1XJR5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_16340</name>
        <name evidence="5" type="ORF">CYQ11_11735</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51379">
        <property type="protein sequence ID" value="PHQ51379"/>
        <property type="gene ID" value="BLA24_16340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16499">
        <property type="protein sequence ID" value="PPT16499"/>
        <property type="gene ID" value="CYQ11_11735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="82"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="399" mass="43499" checksum="7386C5CBD668E251" modified="2018-01-31" version="1">MRRLALALALALLLVAGIGWVLYEQLNNNITTDTETAEELARWEKQRPSALVAGAQNILIIGSDTRSGSGNGKYGGDSGTQRSDTTILLHVAADRNSATAVSLPRDLMAKIPSCRKPDGTYTNERFAQFNWAYELAGTACTIRTVEGITNIRIDHHIVLDFIGFKRLVDAVDGVEVCLRKPMDDREAHLRLPAGRQVLHGEAALGYVRARYSLGGGSDTERMGRQQEFLGALFREMRSDGILLNPTRLYPVLDAATRSLTTDSGLDSLRKMYDLVRTVRNIPTDRVQFLTAPRKPYAYNANRDELVQPDADQLFEQLRRDRPVSVSAHVRPADGKPGGGPRRDPDPEEPESTELPSDPFAQPSAPPPPASSSAPSPAPSPRPTTPPTYQGTTAAHGICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJU5</accession>
    <name>A0A2G1XJU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13470</name>
        <name evidence="2" type="ORF">CYQ11_01190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51512">
        <property type="protein sequence ID" value="PHQ51512"/>
        <property type="gene ID" value="BLA24_13470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11694">
        <property type="protein sequence ID" value="PPT11694"/>
        <property type="gene ID" value="CYQ11_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="439" mass="46700" checksum="23B9F81BA727FD2E" modified="2018-01-31" version="1">MSLNSNSRFRPSRRTFLLTATAGALGVGGYTGWELLRDKDVAVPPTRAPLWDFEARQTGGRLNFSLAVDGGGVFAATSSPGILALDATTGRKRWSARLGEGSWESGSVTVADGSAYLVTATGAVQAYRADDGELLWSARELGSGYSGAAAVLGSTLCVQLTRYVDDEGPGKPGALCGLDSATGRVRWTTPASGIFQPLPGRQLLFARTGELTDETHDARPVGAVNPLTGAVAWEAPASADEETIGLSPDGDTVYLLDEEHRLCAYATGTGERRWRVPAMDGVITVTEDGGTVYVCTYRGDLASYDARSGERRWRRTVAKGYSRPAVAHRDGRVFITSGDGYGFDSFFGMGGERGYVLALAADSGKELWRVNRMEPCSSPPTAVGDDVIVTHSADWWAYDARTGKPRWRLAAASSITADPYVASGVLYGLCDDGIRAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJZ2</accession>
    <name>A0A2G1XJZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_13115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000144">
        <property type="protein sequence ID" value="PHQ51547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51547">
        <property type="protein sequence ID" value="PHQ51547"/>
        <property type="gene ID" value="BLA24_13115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="45"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="185" mass="19360" checksum="3C353F9C718F933A" modified="2018-01-31" version="1">MVRIYNLQPGTQYTVAVAVRDRAGHDTKPGKASSFRTTGSGGGTTAPNTRYLLNNGGTGNAAEIWGGRTADGTVLVGSRTNGYAGQQWYFDDAGSGYQRIRSAVSGKCLQLGGPAGAGTWVAQQPCGNADSQKWRLSPKGSGVTVAAKSGNYVLGVSNRPYYGSWLLELQSPDGRAAQVWAVQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL4</accession>
    <name>A0A2G1XKL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11880</name>
        <name evidence="3" type="ORF">CYQ11_03120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51775">
        <property type="protein sequence ID" value="PHQ51775"/>
        <property type="gene ID" value="BLA24_11880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12022">
        <property type="protein sequence ID" value="PPT12022"/>
        <property type="gene ID" value="CYQ11_03120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="182"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="343" mass="37921" checksum="335EF641307E582C" modified="2018-01-31" version="1">MRRTETYRTRVVRTVEDLAPETTELAAAAGASEFYYGHEFLRAYEREPIQPVHAVYYIEVLDEDDRVIALTPCYVQGDPLRALGMGPDEKALLSHVWHCSDTQLASTRTDSRVAGAIVARMREIAASAGLARCGFINVATGSPSALALEGAGLTGTDLDTRYTVDLAAAGSWEGYLSTLRYNARREYARQLRRADDCGVKVTERVPDGEEDPQSLQIFEVLMANVGSAGYYSKERIAAFLRYTRKGARIIEVTMDGEIIAKAVVFLETKKIHAWAGGYDRNADVASGRPFSSYYVLMSAIIKLGLRAGVPTLEGGRRNGEFKVRYGMRPQPLKAYMTDVRHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKT8</accession>
    <name>A0A2G1XKT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_12240</name>
        <name evidence="11" type="ORF">CYQ11_03475</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51840">
        <property type="protein sequence ID" value="PHQ51840"/>
        <property type="gene ID" value="BLA24_12240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12086">
        <property type="protein sequence ID" value="PPT12086"/>
        <property type="gene ID" value="CYQ11_03475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2000"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3520"/>
            <end position="3595"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="5044"/>
            <end position="5119"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2035"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="3555"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="5079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="5201" mass="542859" checksum="6B78D1937C521A55" modified="2018-01-31" version="1">[encoded data, 5201 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL83</accession>
    <name>A0A2G1XL83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ammonia channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_10210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000111">
        <property type="protein sequence ID" value="PHQ52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52003">
        <property type="protein sequence ID" value="PHQ52003"/>
        <property type="gene ID" value="BLA24_10210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="7">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="82" mass="8580" checksum="CF41FB0082BFDB80" modified="2018-01-31" version="1" fragment="single">MNGADTAFVLISAALVMLMTPALAFFYGGMVRVKSALNMLMMSFISLGIVSVLWVLFGYSLAFGDDIGAGLLGDLGHVGFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLB8</accession>
    <name>A0A2G1XLB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000100">
        <property type="protein sequence ID" value="PHQ52054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52054">
        <property type="protein sequence ID" value="PHQ52054"/>
        <property type="gene ID" value="BLA24_09760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013558467" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="102" mass="9774" checksum="D0FBCC068606A0A7" modified="2018-01-31" version="1" fragment="single">MKVRALLATAALLLGGGGTALVAADASAGGTHRPAAGGAQEQAAATATTIACPDVGDRLQDVPAPARQQVSAGLAELDAQIARAYEKAAAPGGDSGAVLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLP1</accession>
    <name>A0A2G1XLP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09455</name>
        <name evidence="6" type="ORF">CYQ11_28065</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52136">
        <property type="protein sequence ID" value="PHQ52136"/>
        <property type="gene ID" value="BLA24_09455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16216">
        <property type="protein sequence ID" value="PPT16216"/>
        <property type="gene ID" value="CYQ11_28065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="984" mass="104359" checksum="AC80D572BBE18940" modified="2018-01-31" version="1">MTDIDAVAGDGELRFSVLGPLRAWRGEQALELGSPQQQSLLAELLLRRGRPASAAEIVDALWGDRPPARAVGTLRTYASRLRKLLEPGRGAGATPRILVSVSDGYALRVPRRAVDAARFEDQLAAARRARTVGRPAEARALLRAATALWNGEPLTGLTGAAVPAHRARLTELRLTALESRLELDLELGAPEAALPELSALTARHPLRERLRALHVLALHRDGRHAEALAAYEDTRRVLAEELGLEPGRELAAVRRCLTAPRPAADRCAADDAYEPAAAAGLPGDLADFTGRTAAVAELCAALAPASRQGAVTVAVSGIGGVGKSALAAHVAHRLRADFPDGRLYADLRGTRESPAEPAAVLGSFLRALGVPGSAVPDGPAERAALFRTRLADRRVLIVLDDARDADQVRPLLPGTPECAVLVTGRAKLAALPSVRLVDLDVMTVPEALALLAGIVGEGRTRAEPEAAEQLVAACGFLPLAVRVAATRLATRPSWTLAALAARLADPHRRLGELRVAGLSVEDALAAGHERLDSRERRALALLALPDGPDVCAAAAGAVLGVTEREAEPLCESLVDASLLESPAPGRYRFHDLLRLHARARAEAEVPPRERAAALRRLLDFYVATARAAHLLAGPGTDRLQVGTRGPGLSFDNVEAARAWIFAEAPCLFAAARQAAAAADTCASAADLLLMMDVLFEYGAHEREFEEAARAVTAGAPAHGDGRAAGRAGLALGYVYYYADRIDELVPVCHEVLALSRAAGDDLVTADCLVQLSRCAQHMRRHEEAHGLLAEALAVFRAHGDRYGEANATGALARVYLSLGQGDRALAAAERCLAVHRGLGGGHRVAFGLYRLGVVLAGVGRATEAAEHLTEALGLFRGRRNRLWEGLTLFRLAETRLRSGHVEEAVIHAELAVAALAEVGESWGRAKALHVLGHALDQLSRPDRARACWLAAHAFFARMGVPEADDLQVLIGWEGSYEGETGWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR2</accession>
    <name>A0A2G1XLR2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09575</name>
        <name evidence="3" type="ORF">CYQ11_28185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52156">
        <property type="protein sequence ID" value="PHQ52156"/>
        <property type="gene ID" value="BLA24_09575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16237">
        <property type="protein sequence ID" value="PPT16237"/>
        <property type="gene ID" value="CYQ11_28185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="36240" checksum="DA7650C61E5472DC" modified="2018-01-31" version="1">MIWLTWRQFRTQILAALAVVAVIGIYLVTLGMQIRDKHDSVLDQCRSHGNCPSLLASFTDQFHVQVSILGYLLIVIPGIIGMFWGAPLITRELELGTHRLVWNQSVTRKRWLAVKLGFVGLCSMAVTGALSLLLTWAAGPFDQVQADRFTPIPFAARNIVPVAYAAFAFVLGVTLGLFIRRTLAAMAVTLVLFGVVQVAMPNMIRPNLVTPVSSTVKLTPTALESLSFLGQYGDIGGLKVPSGDWVVETSPMLNSAGKNIGHTAMYANCINNSVQSSMLKCLADADLHVEVKEQPASRYWKFQWYEAGLFALVTAVMAGLSFWRIRGRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR5</accession>
    <name>A0A2G1XLR5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52167">
        <property type="protein sequence ID" value="PHQ52167"/>
        <property type="gene ID" value="BLA24_09640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="140"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="521"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="870" mass="91740" checksum="CFE9B6A397785071" modified="2018-01-31" version="1">MASPMSFAQRRLWFQGRIEGPSATYNIPMIVRLTGEGLDSAALGAALRDVIGRHEVLRTVFPEADGEPQQRVVELDDLPWELAVVRVAAEEGGPARAGQRLAAWDDLPWHQQVLDLPMVEPADELPGAEVPAEDLAGAVARAASYVFDLTTEIPIRAWLFEAAPKEHVLVVVMHHIAGDGWSSGPFARDLARAYAARCAGDEPRWPSPLPVQYADYALWQRELLGDETDPTSVLARQIAHWREELAGAPEGLELPVDRPRPVQASYRGHMVGFSVPADVHRALSSLARERRATLFMVLQAGLTVMLSKAGAGDDIPIGAAVAGRTDEALGDLVGCFVNTLVMRNDLTGDPTFTELLDRVRGTTVRALAHQDVPFEKLVEALAPSRLPARHPLFQVALSLLDVGPAVELPGLRSDALSIGRPGAKFDLEVMIGEVFDAEGAPAGLRGGLTVSADLFDMGAAERFASWFVRVLTAVSADPGVRVSEVEVLSSAERGVLLGGWGGGGVVSVPDVSVPELFGVWVGRAPGAVAVVCGDVSLMYGELGDRVSRLARCLVAAGVGSESRVAVLMERSVDVVVVLLAVLRAGGVYVPLDVAWPVGRMEEVVGDAGACVLVVDAGLVGHGLVGWARAGGVGVVSADAEMDVECDAGVLLPVVRAGQAAYVMYTSGSTGRPKGVVATHGDVVRLALDRCWGASGSMRVLFHAPHAFDASSYELWVPLLSGGTVVVAPPVAVDAGVLRRWVADFALTHVHVTAGLLRVLAERDPGCFVGVREVLTGGDVVPAGAVRRVLECCAGVVVRHLYGPTEVTLCATQWVVSDAAVVGDVVPMGRGLDNTRVLVLDGSLCLVPPGVVGELYVVGAGVARGMWVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMH5</accession>
    <name>A0A2G1XMH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06625</name>
        <name evidence="3" type="ORF">CYQ11_26775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52455">
        <property type="protein sequence ID" value="PHQ52455"/>
        <property type="gene ID" value="BLA24_06625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15987">
        <property type="protein sequence ID" value="PPT15987"/>
        <property type="gene ID" value="CYQ11_26775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="148" mass="16094" checksum="CE7907339F00874E" modified="2018-01-31" version="1">MKDPETSAGTLADKLNHLFQTVIPAGREPYSTEEVARAITAGGVSISGSYIWLLRKGQRDNPTLRHVEALAKFFGVPPAYFFDDQVTAAVNADLRLLVALRDTQVQRVALRAAGLSAASLHSINEVIERVRELEGLPTSRANPTESQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMK8</accession>
    <name>A0A2G1XMK8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06550</name>
        <name evidence="4" type="ORF">CYQ11_26700</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52440">
        <property type="protein sequence ID" value="PHQ52440"/>
        <property type="gene ID" value="BLA24_06550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15972">
        <property type="protein sequence ID" value="PPT15972"/>
        <property type="gene ID" value="CYQ11_26700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="2">
        <location>
            <begin position="258"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="664" mass="70950" checksum="0B1AEF1377DDAE5E" modified="2018-01-31" version="1">MTLTDPGPATAAPTAPGALLAPGVPADWPWPPACGDELVTVAGAFDEEWETAAHCRAVAEGRPWLSVRITAAEILVGPLWTPTAAVGCSGCAETRALAAVSDPLFFVTDRTLRTPASARGGNGAPPLLRTLLAAYGELLRTEPLAPGELLALSTDRGVRRHRVHRSIDCTVCGDPAPTPQDAETLPPVPPEPVALCSRPSSAAVPTRGDDGPDLRREAMRENLVDHRFGPVTQMFRDDNAPFAMTGAVLGGARFPGFGRGCSFDATEPVAVLEAYERFGGYPHQASLVRGRSHRELGDLALDPDRLGRYTERQLASPISRVLARTADTPMDWAWGHRLAGGEPLLVPADVAFYQYGYPEPGGRPDMAFQRARRPDSGGRASTRANYFLESSSGCALGGSREEAALHSLFELAERDAILMAWHAQQPLAHLDHAEVRADPEARHLMDLIEAADYDIHLLVTTSDLALPSVWALAVHRRRALPASFTAAGAGPDPMTAVRAGLWEISQLVGHGLNWDPDDVAPMLDDPWKVDMLVDHHRLYGFPETLPRVEKVLGGPRLTLAEAFPGWPGVFAEAAAGDVRGALEFMAGHFAAAGLDEIVIVDQTTREHADLGLASVKAVVPGIVAMSFGHAQQRLAGLPRFATRTAGAGVPCDEELLPLDPHPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMS5</accession>
    <name>A0A2G1XMS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06785</name>
        <name evidence="2" type="ORF">CYQ11_26935</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52481">
        <property type="protein sequence ID" value="PHQ52481"/>
        <property type="gene ID" value="BLA24_06785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16014">
        <property type="protein sequence ID" value="PPT16014"/>
        <property type="gene ID" value="CYQ11_26935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="12906" checksum="EC5483EA47C6971D" modified="2018-01-31" version="1">MVDPMSLTAISTAVTAAAGAAGTEAGRRMWGSLTDLARRAFGRGGEDDGAAPLPLDPRSEEQVRELAALIFTQGRQDPRFAAEFREWAERASALSVDNSTVTNNFSGRGGVVYQGRDFTIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN86</accession>
    <name>A0A2G1XN86_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ketosteroid isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05415</name>
        <name evidence="3" type="ORF">CYQ11_01875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52714">
        <property type="protein sequence ID" value="PHQ52714"/>
        <property type="gene ID" value="BLA24_05415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11808">
        <property type="protein sequence ID" value="PPT11808"/>
        <property type="gene ID" value="CYQ11_01875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="129" mass="14249" checksum="EFF533B5548DBF05" modified="2018-01-31" version="1">MVTDNRQLITGAYDAFGAGDVPAVLQAFAEDITWHVPGRGPLSGDYRGHQELVGFFGRVMELSGGSFRIRVDDVLTDASRVVVLCTVSAERDGRSWSSPEVHVWEIADGRAVAFREFQGDQQAEDEFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN93</accession>
    <name>A0A2G1XN93_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05470</name>
        <name evidence="3" type="ORF">CYQ11_01930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52724">
        <property type="protein sequence ID" value="PHQ52724"/>
        <property type="gene ID" value="BLA24_05470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11818">
        <property type="protein sequence ID" value="PPT11818"/>
        <property type="gene ID" value="CYQ11_01930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042925">
        <property type="term" value="F:benzoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004711">
        <property type="entry name" value="Benzoate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30199">
        <property type="entry name" value="PTHR30199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03594">
        <property type="entry name" value="BenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00843">
        <property type="entry name" value="benE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="493" mass="51436" checksum="9182272F953B7759" modified="2018-01-31" version="1">MRRSDVFTQAVYILVGTNDLPFRTEAARKAHQPGRRCGPTSLAATAVRATTVPITAVHLTAVHLFVHGKAVDADRTHVIKFSTVPLIRHIRAVAPPSAVTAGFLAVLIGFTSSVAIVITAAETAGATSAQLTSWIFALGIGMGVTCVGLSLRYRAPVVTAWSTPGAALLATGLHGVSMPQAVGAFILSAVLVVVSGVTGWFERVMDKIPVPLASALLAGVLVQFGTGLFTKMQQNFAVVFPMFAVYLLCRRWLPRYAVIGALAIGIAASACQGSWRLGGLHLGLAEPVFVRPEFSWQVLVGVGLPLYVVTMASQNLPGVAVMRNAGYRTPVSPLLTWTGVVTALLAPFGCFGLNLAAITAAICMGEEAHEDPRRRYLAAVWAGLFYVTVGLFAGVVGWLLTAMPTALIMGIAGLGLLGTIGGSLSAALADEGMREPAVVTFLATASGMTLFGIGSTFWGLLAGVLATAVLRSRRRTATAVTPAPEPGREPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNC6</accession>
    <name>A0A2G1XNC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05660</name>
        <name evidence="3" type="ORF">CYQ11_02120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52752">
        <property type="protein sequence ID" value="PHQ52752"/>
        <property type="gene ID" value="BLA24_05660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11850">
        <property type="protein sequence ID" value="PPT11850"/>
        <property type="gene ID" value="CYQ11_02120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="106" mass="11357" checksum="CCBA6E52326B3F26" modified="2018-01-31" version="1">MLQPMTGEPEEAARIRRMTHTGDETRRFATRGQLTALALLLAGIAVLARWHEGAAFWGGALLGTAGVGGYFVQFDTPRGAAQWLLAAAGFCMLFMFGVQLLVGVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNC9</accession>
    <name>A0A2G1XNC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_06140</name>
        <name evidence="6" type="ORF">CYQ11_03665</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52681">
        <property type="protein sequence ID" value="PHQ52681"/>
        <property type="gene ID" value="BLA24_06140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12115">
        <property type="protein sequence ID" value="PPT12115"/>
        <property type="gene ID" value="CYQ11_03665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="69"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="306" mass="32905" checksum="3FCD2997D8587613" modified="2018-01-31" version="1">MRPRSPLVPPVALLVLASASLVSCGREGVPPGSVAALIGEDESRLAYPVEENVLVTGSPVLKRARAAHRIVIGVKSDHPFLGFEDPVTGRRFGFDIEIARMIAADLGFGPGRITWKTVSSQGRETAISKGDVDFYVAAYTINDERKKHVSFAGPYYVAGQDLLVKQGDQEIHGPGDLKGKRVCSVTGSTPYQRITNPVYGAHVSSHDSYAQCVQDLISGEADAVTSDDTILKGYAAQNGGRLRVVGRRFSEEPYGVGLVRGDKVLRGAINDALDRHRRNGDWLRAYGATLGRSGVPAPAPPEVIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNF0</accession>
    <name>A0A2G1XNF0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit DhaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaK</name>
        <name evidence="2" type="ORF">BLA24_06130</name>
        <name evidence="3" type="ORF">CYQ11_03655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52679">
        <property type="protein sequence ID" value="PHQ52679"/>
        <property type="gene ID" value="BLA24_06130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12113">
        <property type="protein sequence ID" value="PPT12113"/>
        <property type="gene ID" value="CYQ11_03655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="34265" checksum="4CB4E1B4234724E5" modified="2018-01-31" version="1">MRMLINVPETVVSDALRGMAAAHPELTVDVERRVVVRRDAPVAGKVGLVSGGGSGHEPLHGGFVGVGMLDAACPGEVFTSPVPDQMVRAAAAVDSGQGVLFVVKNYTGDVLNFNMAAELAEDEGIQVASVLVNDDVAVTDSLYTAGRRGTGATLFVEKIAGAAAEEGAPLGRVEALARRVNESSRSFGVALASCTTPAKGGPTFDLPAGQLELGVGIHGEPGRERRAMMTSGEIADVAVHAVLEDLRPSGPVLVLVNGAGGTPLLELYGYAAEVHRVLRERGVAVARTLVGNYVTSLDMAGASVTLCQVDDELLRLWDAPVQTPGLRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNF3</accession>
    <name>A0A2G1XNF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05845</name>
        <name evidence="3" type="ORF">CYQ11_02320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52784">
        <property type="protein sequence ID" value="PHQ52784"/>
        <property type="gene ID" value="BLA24_05845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11886">
        <property type="protein sequence ID" value="PPT11886"/>
        <property type="gene ID" value="CYQ11_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="34486" checksum="85A1FD029F3DF72A" modified="2018-01-31" version="1">MHRIGVLALDGVLPFELGIPARIFGAARSDRGDPLYSVTTCSLDGRPVRTQADFDIVVSEDASLLAAVDTVVVPPSHALGAVREEGRLSDGLRRAFEGVRPGTRMVGLCTGTFVLGAAGLLENRPVTTHWMEAGLLQRLFATTRVDPDVLFVDDGDVLTSAGVAAGVDLCLHIVRRDHGSAVANEVARACVVPPWRDGGQAQFIRQPVPGPSAGSTAPVRAWALEHLGEPLTLAGLASRAGMSVRTLTRRFRDEVGMSPGQWLAGQRVERARHLLETTDWPVDRIAHHCGFGTGTSLRQHLHSAVGVAPQAYRKTFRTAPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNJ2</accession>
    <name>A0A2G1XNJ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_05655</name>
        <name evidence="9" type="ORF">CYQ11_02115</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52751">
        <property type="protein sequence ID" value="PHQ52751"/>
        <property type="gene ID" value="BLA24_05655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11849">
        <property type="protein sequence ID" value="PPT11849"/>
        <property type="gene ID" value="CYQ11_02115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="9120" checksum="071B3066ACF65300" modified="2018-01-31" version="1">MGIIGWIVLGLLAGAIAKILLPGRDPGGLVGTTLIGIAGAFIGGWLSAKFLHRSISNHFFDAATWGSAIAGSLVLLIAYRILFGNSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN7</accession>
    <name>A0A2G1XNN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_04545</name>
        <name evidence="10" type="ORF">CYQ11_28980</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52848">
        <property type="protein sequence ID" value="PHQ52848"/>
        <property type="gene ID" value="BLA24_04545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11495">
        <property type="protein sequence ID" value="PPT11495"/>
        <property type="gene ID" value="CYQ11_28980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="951"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1046" mass="110390" checksum="6E280B948C087BBE" modified="2018-01-31" version="1">MFGLSTSQEIVWLHEQMLPGSRAYNFTATIDLRGRLDEAALLDGLAAALDRHPGLRLELVENAGALPGQRVRQGCAPRLRSADLSGEDDPEAAFARLLREEAETPLDVHEAPLLRWCVVRLGADHHRIVHVEHHLVHDGHSFAILLHDVFSVYRARVLGEPAALPPAPSYEEHVAAAHGPGREERREASLAHWRRELADASFDMPLPGLARPGARRRHAGGQLRQALDAELAERLRAHSRAQGHTPFSTLLTLFAELLRRHSGRADLVVGTAVGNRPEGFETATGMFVNTIPLRLRLDPAAGADEGVDDVTDGLIRALPHQDVPVQVLTHALGLHTGGADNPLFSVMFSAHDAALPEIDVPGLEVSLFEGFNTGTTRFDLDLVLLPDDRRTVGPRQGPAGMTLVWDYDRDLFDEDTARLLSERFLALVRAYLAAPATPLAALAAEVTPAPGPVAPEVRPDEVLDPVAQADPALVALVSGARKITYGELDGLVEELAGRLRAAGVTAGAPVAAVLPRGVDTVVTLLACLRTGAVYCPLSPRDPAGRLETLLGRLRPALVLADRASALALPAEGLPVALVDGAGAFPAAVPAVTLDGAAYVIHTSGSTGLPKAVVVGRRALAHHASAVAGRFGLNARDRVLLFAQPAFDVALEEVLPSLLAGAALIVPQREVPTAPELVAVLAARRVTVANLPTSYLLAVREELCEALRDGLWEPRLLVVGGERLPAAALRSVLDATGARVLNAYGVTEATVTSTVHEVPREGIADGEGAEVPLGTPLAGTAVHVLDGGLRPLPRGAVGELAIAGVGLADGYLGDEATTAARFVTVPALGGERVYLTGDLGYRDRDGLVCFLGRRDNQVKLRGYRIELEEVEAAVSAVLGGRSCAVVPGRDAAGGPCLTGFLDGGGEVDRALLHEGLSERLPAALVPARWIRLETMPLLPGGKPDRAALGRVAEERAADAEDPAATGQAAAGDGDPALALLGEGWREVLGHDRFSPSSHFFQVGGHSLLAAQLAAWLEPRLGSRPPLRVLFQHPVLADQAHALAEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNT9</accession>
    <name>A0A2G1XNT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04885</name>
        <name evidence="3" type="ORF">CYQ11_28645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52898">
        <property type="protein sequence ID" value="PHQ52898"/>
        <property type="gene ID" value="BLA24_04885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11442">
        <property type="protein sequence ID" value="PPT11442"/>
        <property type="gene ID" value="CYQ11_28645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046198">
        <property type="entry name" value="DUF6230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19741">
        <property type="entry name" value="DUF6230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304932" evidence="1">
        <location>
            <begin position="43"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="204" mass="21029" checksum="A49BE29D7E7E6943" modified="2018-01-31" version="1">MTRADRRLSEGRTVWRKAALVALPAVAAVAAMAVAMGEGVLASSFAVSGQAFQVSSSRLTSKGLVSFVDVDRSADGRGHATALLGVGDATLTDICQAARVNTPLGTVVFSLRAGGEAGNVMVSNLVLHSEDLMGDARFGEVQLGRDASTLDQVPGVRGAPGQFGLQAASVTVSGVRSHTWSVTGGDFRLKGLRLDVGLNDRACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP37</accession>
    <name>A0A2G1XP37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000068">
        <property type="protein sequence ID" value="PHQ52994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52994">
        <property type="protein sequence ID" value="PHQ52994"/>
        <property type="gene ID" value="BLA24_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="76" mass="7974" checksum="DF9DEFBB777D63B4" modified="2018-01-31" version="1">MTGISARSPWAVALFPAAACSALWACSTLPGFPGLPLASPTLPGLLPGVRTVKSNWLIPSEPHLPSAPKEWPMVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPP1</accession>
    <name>A0A2G1XPP1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">disA</name>
        <name evidence="13" type="ORF">BLA24_03350</name>
        <name evidence="14" type="ORF">CYQ11_16935</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53119">
        <property type="protein sequence ID" value="PHQ53119"/>
        <property type="gene ID" value="BLA24_03350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14328">
        <property type="protein sequence ID" value="PPT14328"/>
        <property type="gene ID" value="CYQ11_16935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="12">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="40421" checksum="C9D74DA47662DA0D" modified="2018-01-31" version="1">MAANDRASGPGRAGSGSGGSGVDGLMRASLSAVAPGTALRDGLERVLRGNTGGLIVLGMDKTVEQMCTGGFVLDVEFTATRLRELCKLDGALIIDKDISKIVRAGVQLYPDASIPTEETGTRHRTAQRASIQSGFPVVSVSQSMRLIALYVGGERRVLEESGAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVTAVSQRLEMVRRIATEIAEYVVELGTDGRLLSLQLDELIAGVEPERELVVRDYVPEPTAKRTRTVPEALSELDSLTHAELLELPIVARALGYSGSPETLDSAVSPRGYRLLAKVPRLPGAIIERLVDHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPQ1</accession>
    <name>A0A2G1XPQ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02445</name>
        <name evidence="4" type="ORF">CYQ11_04810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XPQ1"/>
    <dbReference type="EnsemblBacteria" id="PHQ53214">
        <property type="protein sequence ID" value="PHQ53214"/>
        <property type="gene ID" value="BLA24_02445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16354">
        <property type="protein sequence ID" value="PPT16354"/>
        <property type="gene ID" value="CYQ11_04810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="500" mass="55555" checksum="E3C14FADEF18D55C" modified="2018-01-31" version="1">MKTANRHGGHGWPDIHRIPHPPHRIPFLGDLVGAHPATPVQDTMNIARNLGPIFRRKVFDHEFVFVSDSSMAAELVDESRFRKHVAESMTDLRDIAGDGLATAYHHEPNWQRAHDILVPAFTREALKSYHPTMLAATRRLLDSWDRCVGGAPVDVSRDMTKVTLETIARAGFGYDFGSFERADPHPFVRAMVRALKFSQQNAVEVPYIGSLLTRRAKRRNAQDTALMAEIVDEVVHRRMADGDTGTHDMLGLMLNTAHPETGERLAPANIRNQVITFLVAGHETTAGALSFALYYLVKNPALLAAAREEVARVWGGGADPDPSYEQVTKLRHVRRCLEEALRLWPTAPGFAREALEDTVIGGRHPMRRGAWAVVFTPMLHRDPVWGGDVERFDPDRFTPERVRARPAHVYKPFGTGARVCLGRQFALHEATLVLAMLVHRYELEDHADYQLKVHERLTLMPTGFTLALAHRAHHADGPGAASAGAGRETSQNGAPEPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQD5</accession>
    <name>A0A2G1XQD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00345</name>
        <name evidence="3" type="ORF">CYQ11_07355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53420">
        <property type="protein sequence ID" value="PHQ53420"/>
        <property type="gene ID" value="BLA24_00345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12725">
        <property type="protein sequence ID" value="PPT12725"/>
        <property type="gene ID" value="CYQ11_07355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010951">
        <property type="entry name" value="CM_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01795">
        <property type="entry name" value="CM_mono_cladeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="101" mass="11426" checksum="E6DEC4FBA212FA4F" modified="2018-01-31" version="1">MNNSANDESVRAELTRLRDSIDNIDAAVIHMLAERFKCTQQVGHLKAAHKMPPADPARESRQIARLRELAENAKLDPAFAEKFLNFIIAEVIRHHETIARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQE4</accession>
    <name>A0A2G1XQE4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="9" type="ORF">BLA24_00550</name>
        <name evidence="10" type="ORF">CYQ11_07560</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53456">
        <property type="protein sequence ID" value="PHQ53456"/>
        <property type="gene ID" value="BLA24_00550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12761">
        <property type="protein sequence ID" value="PPT12761"/>
        <property type="gene ID" value="CYQ11_07560"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="13242" checksum="690BD0ED14A9A41F" modified="2018-01-31" version="1">MTGNARPLSGLDPAIAARLKRSVDGLVPAIAQQYDTGEVLMLGWMDDEALHRTLTSGRCTYWSRSREEYWVKGETSGHAQHVKSVALDCDADALLVKVDQVGPACHTGTRTCFDADVLPLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQF7</accession>
    <name>A0A2G1XQF7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosyl isomerase A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8">5.3.1.16</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="8">PRAI</shortName>
            <ecNumber evidence="8">5.3.1.24</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">priA</name>
        <name evidence="8" type="synonym">hisA</name>
        <name evidence="10" type="ORF">BLA24_00655</name>
        <name evidence="11" type="ORF">CYQ11_07665</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in both the histidine and tryptophan biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8"/>
    <dbReference type="EC" id="5.3.1.24" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53475">
        <property type="protein sequence ID" value="PHQ53475"/>
        <property type="gene ID" value="BLA24_00655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12780">
        <property type="protein sequence ID" value="PPT12780"/>
        <property type="gene ID" value="CYQ11_07665"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010188">
        <property type="entry name" value="HisA/PriA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01919">
        <property type="entry name" value="hisA-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="244" mass="25664" checksum="70FCA3FA82E9ECE3" modified="2018-01-31" version="1">MTNASKLELLPAVDVRDGQAVRLVHGESGSETSYGDPLDAARAWQRAGAEWLHLVDLDAAFGTGDNRERIAEVVRAMDIKVELSGGIRDDASLAAALATGCTRVNLGTAALETPEWVARVIAEHGDKIAVGLDVRGTTLRGRGWTRDGGDLYETLARLDSEGCARYVVTDIAKDGTLQGPNLELLKNVCAVTDRPVVASGGVSSLDDLRAIATLVPEGVEGAIVGKALYAKAFTLEEALEAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQG0</accession>
    <name>A0A2G1XQG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00405</name>
        <name evidence="4" type="ORF">CYQ11_07415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53431">
        <property type="protein sequence ID" value="PHQ53431"/>
        <property type="gene ID" value="BLA24_00405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12735">
        <property type="protein sequence ID" value="PPT12735"/>
        <property type="gene ID" value="CYQ11_07415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304953" evidence="2">
        <location>
            <begin position="27"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="361" mass="39821" checksum="86D7CBFF5A53A1AE" modified="2018-01-31" version="1">MTAMGRTAAVFAAVAVLLVAGCSSSGDEDAPVPQDSGRTGGQPDDRKVNGMRGMTLPSWNTDDYGSPQAGTYLRQIAATGARWVTFTPTWYQDRVTDSALRTTGETAGDDSLRHIIRLAHEAGLKTMLKPHVDLVKGGDRAEIRPRDPDAWFADYERFITHYARLAADTGVEQFAVGTELAGTSGEGGRWSRTIAAVRERYKGPLTYAANYDEYRSVPFWKDLDVIGIDAYWPLADKATTDPARLRQAWQPIAETLAAFSARQHRKILFTEAGYVSQRGSTTAPYSWTVSKRDGDAEQAAAYDALLAAFDGKSWWEGVCWWMWDDWPDSGETAKRLAYTPHGKPAEQVLRRWWAKPGSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQG6</accession>
    <name>A0A2G1XQG6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan synthase subunit(Beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00520</name>
        <name evidence="3" type="ORF">CYQ11_07530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53450">
        <property type="protein sequence ID" value="PHQ53450"/>
        <property type="gene ID" value="BLA24_00520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12755">
        <property type="protein sequence ID" value="PPT12755"/>
        <property type="gene ID" value="CYQ11_07530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="73" mass="7950" checksum="B0766A1E17B53951" modified="2018-01-31" version="1">MSGRRTSATEPGARPAPAGVPAAQGPHARWARGCRPRGCRAPARRVRGRRVRYHIGCEPGQINGRRWRGAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9W2</accession>
    <name>A0A2G1X9W2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31335</name>
        <name evidence="4" type="ORF">CYQ11_24375</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47959">
        <property type="protein sequence ID" value="PHQ47959"/>
        <property type="gene ID" value="BLA24_31335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15583">
        <property type="protein sequence ID" value="PPT15583"/>
        <property type="gene ID" value="CYQ11_24375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="22876" checksum="3B90247D8B2E751E" modified="2018-01-31" version="1">MAPRRNAGPDGLTFTERARREQIVECAIDLISTRGYPATSLAAIAEEAGISKASVLYHFTSKDNLDRATLAHVMERFSAHVTERVERESDPVAAVVAYVRAMISYQQANRRHVRVITEMLLDDEGGTRLKTPGSHDTNDRWQGLARLLAAGQEAGCFRAFDTRTTALAVGGSIDNVVSYWLVHPEFDLDAAADELVTFTLNAIERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9W3</accession>
    <name>A0A2G1X9W3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_31655</name>
        <name evidence="6" type="ORF">CYQ11_24710</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48012">
        <property type="protein sequence ID" value="PHQ48012"/>
        <property type="gene ID" value="BLA24_31655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15638">
        <property type="protein sequence ID" value="PPT15638"/>
        <property type="gene ID" value="CYQ11_24710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="22684" checksum="9EB974E89009FB8F" modified="2018-01-31" version="1">MSAPRGPGGVVRVLLVDDHPVVRRGLRAMVDELPDVEAVGEAADGAEALRLLDGGARPDVVLMDLQMGAGMHGVEATRRITARPGPPAVLILTTYSTDADILAAVEAGATGYLLKDAPPEEVTAAVHAAARGETVLAPPVAARLLGRVRAGCRPVLSPRETEILGLLAEGLANRQISRRLFISEATVKTHLVHIYGKLGVDSRTAAIAAGLAAGLIRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Z6</accession>
    <name>A0A2G1X9Z6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FhuF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31975</name>
        <name evidence="3" type="ORF">CYQ11_25030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48067">
        <property type="protein sequence ID" value="PHQ48067"/>
        <property type="gene ID" value="BLA24_31975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15693">
        <property type="protein sequence ID" value="PPT15693"/>
        <property type="gene ID" value="CYQ11_25030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF" evidence="1">
        <location>
            <begin position="76"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="254" mass="27186" checksum="55A578A8B615571A" modified="2018-01-31" version="1">MGVGRRTKSCRAGWPCCPPAAGHRGGAARAGPCEVRQDLVEGVQSGDLRGEAACRSRRRAWSAPHTVRLLDWHTTLFSYGVALESHQQNTSIVLDGHGGLPRMRLLLKDNDGPRVHPARLAARIGGAAAAGLLGFADPRVLVTDDGPLADLFTTVPVHLCAAALAFELAERGRGPLDTWLGLVRDRLTEAVDRLPAEPAAVLRARVLKAPRLPIKAMVTAGTLFSKDRSGAVDINKYYVDGPNYLLPTDSGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA04</accession>
    <name>A0A2G1XA04_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_31840</name>
        <name evidence="7" type="ORF">CYQ11_24895</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48045">
        <property type="protein sequence ID" value="PHQ48045"/>
        <property type="gene ID" value="BLA24_31840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15671">
        <property type="protein sequence ID" value="PPT15671"/>
        <property type="gene ID" value="CYQ11_24895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="25720" checksum="E12C81AB58F39300" modified="2018-01-31" version="1">MEQGRSHTGVSGARAGVPAQAASSARGEHTHEEGATAGRPVHRMPQRYSVRGQILDALRKALFCGELVPGEVYSGPALGERFGVSATPVREAMQQLALEGAVEVVPNRGFRVASRSPRERAELAEVRALLEVPALLRLARTVPTGRWCELRPLAEAAVAAAARGDRAAYAEADRAFHRAVLGFSGNHQLVAVADELHRRAQWPAARDCPAAEHLELLDALAMQDVMAVEALGTRLCGHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA32</accession>
    <name>A0A2G1XA32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uraD</name>
        <name evidence="3" type="ORF">BLA24_32085</name>
        <name evidence="4" type="ORF">CYQ11_25145</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48083">
        <property type="protein sequence ID" value="PHQ48083"/>
        <property type="gene ID" value="BLA24_32085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15709">
        <property type="protein sequence ID" value="PPT15709"/>
        <property type="gene ID" value="CYQ11_25145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="18847" checksum="4508CF45650394F0" modified="2018-01-31" version="1">MTASSTPGLARFNAAGGDEARAALHRICTSTAWAAEVLAHRPYPDAEALLAASDTAVARMGAADLAEAMAGHPPIGRPAPDDPVSAREQRGMADAPADLRARMRELNLAYQEKFGHVFLVCATGLTARQLYDAARNRLDNPPEREQEIVRGELAGINRIRLARLVVQTAEEGADRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD6</accession>
    <name>A0A2G1XAD6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32775</name>
        <name evidence="3" type="ORF">CYQ11_25825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48196">
        <property type="protein sequence ID" value="PHQ48196"/>
        <property type="gene ID" value="BLA24_32775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15822">
        <property type="protein sequence ID" value="PPT15822"/>
        <property type="gene ID" value="CYQ11_25825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="609" mass="66243" checksum="8AFD888876C6B328" modified="2018-01-31" version="1">MREFTVPPVVTAPPVGGLADVVFDHAADDPDRVALGRRPAPGEPWQEVTAAAFRDEVLALAKGLIAQGIRFGDRVAVMSRTRYEWTLFDFALWCIGAQLVPLYPTSSTEQVFWMLHDADVSACVVEHEDHAMTVGSVVDRLPRLARLWQLDAGAVHELTEAGAGIGDDVVHRHRMALTPDSPATVIYTSGTTGRPKGCVLTHGNFMAEADNVVRRYDPVFRSRPGDEASTLLFLPLAHVFGRMVQVAAVRGRVKLGHQPQLTVAALLPDLQEFRPTFVLAVPYVFEGILAAARREAELQGKGRPFEKAVEVAVRYARAQESKAFGTGPGPGTALRVQHQVFDKLVYSKVRETLGGRVRHAMSGGSAMERRLGLFFAGAGITVFEGYGLTETTGAAVANPPERTRFGTVGRPVPGTSVRIADDGEVWLRGGQVFPGYLGDRRATEEVLRGGWLATGDLGALDDDGYLTIIGRKKEILVTSGGKSVPPLVLEERVRAHPLVAQCIAVGNDRPYVAALITLDQEAVAHWRAMREQPPVEPAELVRDPELEAEIRRAVVAANTLVSQAESIRAFRILVGRFTEEQGLLTPTLKLKRKAIEKAYATEVEALYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAH0</accession>
    <name>A0A2G1XAH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32625</name>
        <name evidence="5" type="ORF">CYQ11_25675</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48169">
        <property type="protein sequence ID" value="PHQ48169"/>
        <property type="gene ID" value="BLA24_32625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15795">
        <property type="protein sequence ID" value="PPT15795"/>
        <property type="gene ID" value="CYQ11_25675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="474"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="836" mass="87719" checksum="E147E59C5867ABDA" modified="2018-01-31" version="1">MTVHALDRRVGGTGSSAPEGLPLTAAQSALWSARNLGPGRPSALSTAEYVDIRGDLDGELFAEALHRTVGEADALRVRFAATPDGPRQVDAGTEPPYRGFPFHIADVRHQGDPVARALEWMRADLALPFDLARGPLFAHVLFHVGGDHWLWYHRAHLAVLDGHGHALFARRVADVYTALVGGARPAASPFGRLAALVAEDAAYRASAAHDRDRAHWRRRLAAHPRPAPTLAGPPVPQGPDAPPPHRHTARLGPRTTARLCDLAVSVRATRTEVLFAAQALYLARATGAETVVLGVPMTGRTGSTALRVPAALAGVLPLCFTVTPDTTFAELARQADVGIRAARRHQRHRPAGPAGGTLVHVVPRRPELSFAGAPATAHVVSSGPVDDLTVTFALGEDGGLRVDHEADPTRYDAGELAAHQQRFVHLLTRLADGDPHRPLSALCLATDEERERVLGEFNDTAVAVPPTTLIGPVEAQAARTPGAPALIAEDLTLTYAELNARANRLARHLIGLGVRPGTRAAVALPRSASLVVALLAVLKAGGAYVALAAADARTRLADAERDPALVCVLTDTATRAALPDTGRPLVVLDDTAAAGDLAGHLPTDPGRPLTPRHPAYVVDGVAVPHAAADNLLRWMQGEHPLTAADRVLVKAPPGSAVLAWEVLAPLRAGAALVVAGEQADTTRTIREQGVTVAHFTPSEVASVTGRTPALTGLREVFCDVSRDGVPLPAEVAGRWCEALPDVPLHQLYGPSEAVGVVAHHRCEPGGPGPVPLGRPVWNTRLHVLDSASQPCPPGVTGELYVAGEDARPTGVPARWRPDGVLEHAGGAAAAADRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAK5</accession>
    <name>A0A2G1XAK5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33030</name>
        <name evidence="3" type="ORF">CYQ11_26080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48242">
        <property type="protein sequence ID" value="PHQ48242"/>
        <property type="gene ID" value="BLA24_33030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15869">
        <property type="protein sequence ID" value="PPT15869"/>
        <property type="gene ID" value="CYQ11_26080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="298" mass="32789" checksum="4DDA827996CD1D07" modified="2018-01-31" version="1">MTGPGMKVGAVVLTMGNRPEELRALLESVAKQTGEAIEVVVVGNGSPLPEISVPGLAVRTVELSENVGIPAGRNVGIEAFGPAGRDVDVLLFLDDDGLLPGQDTAQLCREAFAADPELGIISFRIADPDTGETQRRHVPRLRASDPMRSSRVTTFLGGANAARTRVFADVGGLPDEFFYAHEETDLAWRALDAGWMIDYRADMVLHHPTTAPSRHAVYHRMVARNRVWLARRNLPAPLVPVYVGVWLLLTLARRPSLPALRAWFGGFREGWTTPCGPRRPMKWRTVWRLTRLGRPPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAN7</accession>
    <name>A0A2G1XAN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretion protein Rhs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33255</name>
        <name evidence="3" type="ORF">CYQ11_26305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48275">
        <property type="protein sequence ID" value="PHQ48275"/>
        <property type="gene ID" value="BLA24_33255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15905">
        <property type="protein sequence ID" value="PPT15905"/>
        <property type="gene ID" value="CYQ11_26305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="374"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="598" mass="62121" checksum="931BC92362AF33F8" modified="2018-01-31" version="1">MTERLYAAEPVVAFGSPLPEQWAERLVEASVETSVGLPARATLRFRDPEHRLLAALRITVGAPVTVAVAAARRRTRAPIFDGEVTALETEVDADGTFTTIRAMDRGHRLARGRRVAAYVETTVAEVAREAASRHGLTTGRVEAERTRIPHVAQPNLTDWELLNHLADQRGLRLTVEGNTLHMRRPAAADAAPAPGTGADRSPLVLEQGVNLLALRATVSSEGQVAEVEVRGWDPDSKAALSVKAGAGDSERLRLGVTPAQLGKAFPGPAPELLVGGRAHTTAPQVDVAAHAVASESAAAMAMLTAEVAGTPELGAGVPVALAGVGEPFTGKYTVTSCGHVFDGDQGYRSVVRVGPLPPPVVPYPPPLCAPGVAVGVVTDIKEPGKGQRGAVRLRLPWLSQDYVTDWVRTVQWGGAGGGGVFAPEAGDEVLVGFEHGRLDRPYVLGGLYNGLDAPTDHGLPLVDAGTGRANRSSLASRSGDRLELLSVTDGPQGVRLLSGDGKLVTHLDRKDTTIAFAAGEEGKTVRVSLDGRGEGTLTIDAGETGTLILKAGTVTVTAAGSGGGQLTLEGATVTVKSGGELKLEGQKTTITGNTVDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAN8</accession>
    <name>A0A2G1XAN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin resistance protein DrrC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Excinuclease ABC subunit UvrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_33425</name>
        <name evidence="6" type="ORF">CYQ11_26475</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48304">
        <property type="protein sequence ID" value="PHQ48304"/>
        <property type="gene ID" value="BLA24_33425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15935">
        <property type="protein sequence ID" value="PPT15935"/>
        <property type="gene ID" value="CYQ11_26475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="163"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="481"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="521"/>
            <end position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="793" mass="84242" checksum="723EC8074CA70440" modified="2018-01-31" version="1">MPKRTDTHPPAPHAADSHDLIRVHGARENNLKDVSIEIPKRRLTVFTGVSGSGKSSLVFDTIAAESQRLINETYSAFVQGFMPTLARPEADVLDGLTTVIAVDQQRMGADPRSTVGTVTDANAMLRILFSRLGKPHIGPPGAYAFNVPSVHAAGAITVERGAKKAEKVTFKRTGGMCPRCEGRGAVSDIDLSQLYDDSKSINEGAFTIPGYTGGGWNSRLYAESGFFDPDKPIRRFTKKELHDLLHREPTRMKIAGINMTYEGLIPRVQKSMLAKDKEAMQPHVRAFVERAVTFTTCPECGGTRLAEGARSSKIKRKSIADVCAMEIRDLAEWVRGLKEPSVAPLLTALQQTLDSFVEIGLGYLALDRPAGTLSGGEAQRVKMIRHLGSSLTDVTYVFDEPTSGLHPHDVQRMNNLLLRLRDKGNTVLVVEHKPEVIAIADHVVDLGPGAGTAGGSVCFEGTVEGLRASGTVTGRHLDDRAAVKDTVREPAGALGIRGATANNLRGVDVDIPLGVLTVVTGVAGSGKSSLLHGSVSADAGVVSVDQSPIRGSRRSNPATYTGLLDPVRKAFAKANGVKPALFSANSEGACPTCNGAGVVYTDLAMMAGVATPCEECEGKRFQASVLDHHLGGRDISEVLAMSVTEAEEFFGAGEARTPAAHRILGRLADVGLGYLTLGQPLTTLSGGERQRLKLATHMADKGGVYILDEPTTGLHLADVQQLLGLLDRLVDSGKSVIVIEHHQAVMAHADWIIDLGPGAGHDGGRIVFEGTPAELVAARSTLTGEHLADYVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAY1</accession>
    <name>A0A2G1XAY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31340</name>
        <name evidence="3" type="ORF">CYQ11_24380</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48339">
        <property type="protein sequence ID" value="PHQ48339"/>
        <property type="gene ID" value="BLA24_31340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16763">
        <property type="protein sequence ID" value="PPT16763"/>
        <property type="gene ID" value="CYQ11_24380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="407" mass="44735" checksum="4467FB80DB05F353" modified="2018-01-31" version="1">MERTTCCVVGGGPAGMMLGLLLARAGVEVTVLEKHKDFLRDFRGDTVHPSTLRLLDELGLGERFARLPARRLDQVRMHVGDTVLTLSDLRRIPGPHKYIAMVPQWDFLDLLASAAGEEPAFTLRMRTAVTGLRFEDGRVAGVRYTDEDGGPGELAADLTVACDGRDSLVREAAGLRQDLFDVPMDVWNVRVPAQKDDGKDGRVFMRAEGRQFAVTMDRGAYYQTSYLIKKGTDAELRANGIEWFRERIGGLFGWGPEVTDAIRSWDDVKLLEVTMGRLSRWYRPGLLCIGDAAHTMSPTGGVGVNLAVQDAVAAARILAGPLRRGTVRDEDLARVQKRRLMPAALVQKAQRGEHEALLRPALDGVLDHGRLPLPFRLLGRVPLLTTLTGYLGGVGVRPERAPAFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB29</accession>
    <name>A0A2G1XB29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_33120</name>
        <name evidence="2" type="ORF">CYQ11_26170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48389">
        <property type="protein sequence ID" value="PHQ48389"/>
        <property type="gene ID" value="BLA24_33120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16812">
        <property type="protein sequence ID" value="PPT16812"/>
        <property type="gene ID" value="CYQ11_26170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="30752" checksum="5E7F61CB6353E438" modified="2018-01-31" version="1">MGVPGPGIDEVGFPVEDIDTSRPHPARMYDYYLDGWDNYEVDRAAAERVIEVHPQVRLSARANRAFLRRAVREAVGSGIRQILDIGTGIPTSPNTHEVAREVSPDVRVAYVDNDPIVATHAGARLTDEGGTGFALGDVRSPGAILRDPVVRGLIDFDEPVALLLVAVMHFVKDEEDPAGIVATLGDALPAGSWLVLSHATEEPYEAYEGGRTDYAARDGVVNVYKNATAPLNLRRRAAIEPLFGDFRLLEPGLVRVPLWRPDGPVPGAEELNNTVFYGGVGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBA1</accession>
    <name>A0A2G1XBA1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF320 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_29500</name>
        <name evidence="9" type="ORF">CYQ11_05975</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48496">
        <property type="protein sequence ID" value="PHQ48496"/>
        <property type="gene ID" value="BLA24_29500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12505">
        <property type="protein sequence ID" value="PPT12505"/>
        <property type="gene ID" value="CYQ11_05975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304544" evidence="6">
        <location>
            <begin position="29"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="7">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="280" mass="26852" checksum="66B93EB881AD07CA" modified="2018-01-31" version="1">MRQVTKKGLITVAAASGVLAVTGGYAQADSGAMGAAAHSPGVGSGNTVQVPVHVPVNACGNTVNVVGLLNPASGNRCFNGGHGGGVHAGGAHGGGVHGGGLANGKAENSPGVASGNTVQAPISVPVNACGNSVNVVGIGNTATGNECVNGGGHTGGHQSGHEHKPPHGHEPGHPGGHDHGGRHNPPAEQKPGHKPPAHHGGQPAGHPGAPGGHQAKPATAVKDAHRAPEVLAEHRPATVAEKASELAHTGAGQLGAAGAASAGLLLGGALLYRRARGAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBE0</accession>
    <name>A0A2G1XBE0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29815</name>
        <name evidence="7" type="ORF">CYQ11_05660</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48548">
        <property type="protein sequence ID" value="PHQ48548"/>
        <property type="gene ID" value="BLA24_29815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12451">
        <property type="protein sequence ID" value="PPT12451"/>
        <property type="gene ID" value="CYQ11_05660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="2"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="455" mass="47600" checksum="B88BF43E5262660B" modified="2018-01-31" version="1">MDILNPATEEVVATVPDSTARDVDAAVRRAAAAQPAWAALAPGDRARALRRFAAAVDAHLEELALLEVREAGHPIGNARWEAGNVRDLLDYAAGGAERLTGAQIPVAGGLDVTFHEPLGVVAVIAPWNFPMPIAAWGLAPALAAGNAVLLKPAETTPLTALRLAELALEAQLPEGLFQVLPGRGPVAGAALVEHPGVAKVVFTGSTAVGKQIMAKCAAGVKRVTLELGGKSPNIVFADADVERAAAAAPGAFLDNTGQDCCARSRILVQRRVYDRFMELLEPAVKSFVTGDPADPATQMGPLISAAQRERVRGYVPEDAPAAIRGEAPAGKGFWYPATVLEAAPDDRVATEEVFGPVAVVIPFEDEAEAVRLANATDYGLSGSIWTRDVSRALRLSRAVAAGNLSVNSHSSVRYWTPFGGFKQSGLGRELGPGALAAFAETKNVFIAIDPLEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBK6</accession>
    <name>A0A2G1XBK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29750</name>
        <name evidence="5" type="ORF">CYQ11_05725</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48602">
        <property type="protein sequence ID" value="PHQ48602"/>
        <property type="gene ID" value="BLA24_29750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16365">
        <property type="protein sequence ID" value="PPT16365"/>
        <property type="gene ID" value="CYQ11_05725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="rRNA_proc-arch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="rRNA_proc-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="940" mass="104752" checksum="718311DF47541800" modified="2018-01-31" version="1">MTEDMSPAERYALARQRAAEQATALAPFREMYDFELDPFQIEACRALEAGKGVLVAAPTGSGKTIVGEFAVHLALSQGRKCFYTTPIKALSNQKYSDLVKRYGAAKVGLLTGDNSVNADAPVLVMTTEVLRNMLYAGSQTLVGLGHVVMDEVHYLSDRFRGAVWEEVIIHLPESVTLVSLSATVSNAEEFGDWLDTVRGDTEVIVSEHRPVPLWQHVLAGRRMYDLFEEKATPDGGRSRREVNPDLVRLARMENSRTYNPRERRRGKMVREAERERERRQRSRIWTPSRVEVIERLDAEGLLPAITFIFSRAGCEAAVQQCLYAGLRLNDDEARARVRAIVEERTAAIPDEDLHVLGYFEWLEGLERGIAAHHAGMLPTFKEVVEELFVKGLVKAVFATETLALGINMPARSVVLEKLVKWNGEQHADITPGEYTQLTGRAGRRGIDVEGHAVVLWQRGMDPAALAGLAGTRTYPLRSSFKPSYNMAVNLVSQFGRHRSRELLETSFAQFQADKSVVGISRQVQKNEEGLAGYREAIECHLGDFDEYARLRRELKDRETELAKQGAAQRRAAAAAALERLKPGDVIHVPTGKYAGLALVLDPGVAPARSDRHRGFDYHDGPRPLVLTAERQVKRLAEIDFPVPVEPLERMRIPRSFNPRSPQSRRDLASALRTKAGHLVPDRHRKSRAAAADDTEIARLRAAIRSHPCHGCDEREDHARWAERYHRLQRDTRQLERRIEGRTNTIARTFDRICALLTDLDYLHGDEVTEDGRRLARLYGELDLLASECLREGVWDGLGPAELAACASALVYEARAADDAMPPKLPAGAAKEALGKMVRIWGRLDALEEQHKINQAEGVGQREPDLGFAWPAYRWASGHGLDEVLREIDMPAGDFVRWSKQLIDVLGQIAAAAPSSSPVARNARRAVEGLLRGVVAYSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBM6</accession>
    <name>A0A2G1XBM6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrA</name>
        <name evidence="17" type="ORF">BLA24_28315</name>
        <name evidence="18" type="ORF">CYQ11_07155</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48626">
        <property type="protein sequence ID" value="PHQ48626"/>
        <property type="gene ID" value="BLA24_28315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16403">
        <property type="protein sequence ID" value="PPT16403"/>
        <property type="gene ID" value="CYQ11_07155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="603"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="949"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="645"/>
            <end position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ48626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT16403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="986" mass="108518" checksum="483257A08814661B" modified="2018-01-31" version="1">MTDRLIVRGAREHNLKNVSLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLFARIGKPHCPECARPISRQSPQAIVDRVLELPEGSRFQVLSPLVRERKGEFVDLFADLQAKGYSRARVDGETIHLTDPPKLKKQEKHTIEVVVDRLTVKDSAKRRLTDSVETALGLSGGMVILDFVDLPEDDPERERMYSEHLYCPYDDLSFEELEPRSFSFNSPFGACPDCTGIGTRMEVDPELIVPDPDKSLDEGAINPWSHGHTKDYFSRLVGALADALGFRTDIPWAGLPQRAKKALLNGHKTQIEVRYRNRYGRERAYTTAFEGAVPFVKRRHSEAESDSSRERFEGYMREVPCPTCEGTRLKPIVLAVTVQGRSIAEVSAMSISECADFLRDMKLTGREKKIAERVLKEVNERLKFLVDVGLDYLSLNRAAGTLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNHRLIETLVRLRDMGNTLIVVEHDEDTIKVADWVVDIGPGAGEHGGKVVHSGPLKELLSTEASMTGQYLSGKKSIPTPDVRRPVDPKRRITVRGARENNLRDIDVSFPLGVLTAVTGVSGSGKSTLVNDILYTHLARELNGARAVPGRHTRVDGDDLVDKVVHVDQSPIGRTPRSNPATYTGVFDHVRKLFAETMEAKVRGYLPGRFSFNVKGGRCENCSGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKSIAEVLDMPIEEALSFFEAVPTIARHLRTLHEVGLGYVRLGQSAPTLSGGEAQRVKLASELQKRSTGRTVYVLDEPTTGLHFEDISKLISVLSGLVDKGNTVIVIEHNLDVIKTADWVVDMGPEGGGGGGLVVAEGTPEEVAAIPASHTGKFLRDMLGDRVSDAPPLAEPKAPKKRAAAKKTVAAKSGAVKKTVRARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBN1</accession>
    <name>A0A2G1XBN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28250</name>
        <name evidence="2" type="ORF">CYQ11_07220</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48615">
        <property type="protein sequence ID" value="PHQ48615"/>
        <property type="gene ID" value="BLA24_28250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12705">
        <property type="protein sequence ID" value="PPT12705"/>
        <property type="gene ID" value="CYQ11_07220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="107" mass="11731" checksum="6E2D4F4259B1D439" modified="2018-01-31" version="1">MVDLRVDPGQLEAFARQIGRAAEDSREVLGRTRDFTRISARNEGLMGSAIGHHTELRSGVLQALHRLSEILLCSSEELQESAAYYRRTDRAVAAAMDAVHPGEGAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBZ6</accession>
    <name>A0A2G1XBZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27175</name>
        <name evidence="3" type="ORF">CYQ11_18480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48763">
        <property type="protein sequence ID" value="PHQ48763"/>
        <property type="gene ID" value="BLA24_27175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14589">
        <property type="protein sequence ID" value="PPT14589"/>
        <property type="gene ID" value="CYQ11_18480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="171" mass="17039" checksum="EBF6C4DA207B0899" modified="2018-01-31" version="1">MTNEREKPGGGISIGSMSGGAVGQGPGARAEDRSERAGAPAAGAGDPAAAPVPAPDHGGIAVGSLSGGALAQGDDAEAVDASRRLLTVTPELLHVARELRLDLPRLTRAEGDGLDELDAELAGLEDDARREGRTRPGRLARLRALLSDGATAAGGLASAVALVQSISQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC04</accession>
    <name>A0A2G1XC04_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_28480</name>
        <name evidence="7" type="ORF">CYQ11_06990</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48731">
        <property type="protein sequence ID" value="PHQ48731"/>
        <property type="gene ID" value="BLA24_28480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16398">
        <property type="protein sequence ID" value="PPT16398"/>
        <property type="gene ID" value="CYQ11_06990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="30"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="417" mass="45704" checksum="0B0ECFFEA96AF1EC" modified="2018-01-31" version="1">MLLPGLLDTEAIRKDFPILDRVVHDGKKLVYLDNAATSQKPRQVLDVLNEHYERHNANVHRGVHVLAEEATALYEGARDKIAAFVNAPSRDEVIFTKNASESLNLVANMLAWADEPYRVDHETEIVITEMEHHSNIVPWQLLAQRSGAKLKWFGLTDDGRLDLSNIDQVITEKTKVVSFVLVSNILGTLNPVEAIVRRAQEVGALVVVDASQAAPHMPLDVQALQADFVAFTGHKMCGPDGIGVLWGRQELLEDLPPFLGGGEMIETVSMHSSTYAPAPHKFEAGTPPIAQAVGLGAAVDYLTSIGMENIARHEHAITEYAIRRLQEVPDLRIIGPTTAEDRGAAVSFTLGDIHPHDVGQVLDEQGIAVRVGHHCARPVCLRYGIPATTRASFYLYSTPGEVDALVEGLEHVRNFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC85</accession>
    <name>A0A2G1XC85_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper homeostasis protein CutC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27830</name>
        <name evidence="3" type="ORF">CYQ11_17810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48874">
        <property type="protein sequence ID" value="PHQ48874"/>
        <property type="gene ID" value="BLA24_27830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14479">
        <property type="protein sequence ID" value="PPT14479"/>
        <property type="gene ID" value="CYQ11_17810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="233" mass="23735" checksum="B1B814E1DD340025" modified="2018-01-31" version="1">MGSDAILEVIALGAEDAVAARAGGADRLELVCDMAANGLTPPLETFVAVRDAVDIPVRVMLRASDGFAAGGAAALEALCARARALRAEGAREFVLGFLTDDGRADLPAVAALADAVGPDARWTFHRAIDHAADRDALRKQLADQPGLDTYLTAGSAAGVDDGLPTLLAEAARGNEPGYEPRILVGGGLQLKHVPVLRAAGLTGFHIGGAARPHGWAAPVAADAVAAWRAALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC98</accession>
    <name>A0A2G1XC98_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27710</name>
        <name evidence="2" type="ORF">CYQ11_17930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48852">
        <property type="protein sequence ID" value="PHQ48852"/>
        <property type="gene ID" value="BLA24_27710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14501">
        <property type="protein sequence ID" value="PPT14501"/>
        <property type="gene ID" value="CYQ11_17930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23200" checksum="936F911904B7CA82" modified="2018-01-31" version="1">MTSHPSQQESPLFTVGFDLDLTLVDSRPGIRAAYETLVAATGAHIDIDLVVSRLGPPLVHELRNWFPEERVAEAAEIYLAAYPERGIAPSPALPGAREAVAAVRELGGRAIVVTAKHERNARLHLEHLGIEPDRLIGDLWAEGKAVALREHRASVYVGDHLGDVRGARAAGALSVAVPTGPYGAAELREAGADVVLAGGLTDFPAWLRDHRTARDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG5</accession>
    <name>A0A2G1XCG5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28030</name>
        <name evidence="4" type="ORF">CYQ11_17610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48908">
        <property type="protein sequence ID" value="PHQ48908"/>
        <property type="gene ID" value="BLA24_28030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14443">
        <property type="protein sequence ID" value="PPT14443"/>
        <property type="gene ID" value="CYQ11_17610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="24371" checksum="EC7F778922A331B8" modified="2018-01-31" version="1">MPNEITLYLTPEEAASGVTKVVYLPTGSLSVRVPPVQDGGLVRISTDQGPMLLRIRVMGESAPPPAPPPPPAKQPAGKNPLAAAVFTLVALGVLAVVVVLNNSDDSKPSASAPTTGAPSPLFSDSRPRATTAPDGGRTIAPPPVPTPASPFSTGTCLGGTLPDSTTPVTVHNVKRVDCSSSDAHYRVIETFFATTDLGKCRGNPDTQYAYSSETTLGGRTINSIVYCLVGMGSYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCH1</accession>
    <name>A0A2G1XCH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3017 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27210</name>
        <name evidence="4" type="ORF">CYQ11_18445</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48922">
        <property type="protein sequence ID" value="PHQ48922"/>
        <property type="gene ID" value="BLA24_27210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16651">
        <property type="protein sequence ID" value="PPT16651"/>
        <property type="gene ID" value="CYQ11_18445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="25429" checksum="390BBA7297B5781B" modified="2018-01-31" version="1">MRAEPGAPRPGNGAGAKRGQDAGPAGPDAENGASAEQGASAEKGAGTPGGASGPAGKNGVSGENGAGATEGTGKAAGENGAAVTGETAEGAAGANGVSAKNGVSAKSSAGAKNGVGAEAGAGVTEGTGDAADAPAVGKSSRRPPRVTRDTARPEGGGRAAPGGAPAPARQWPLLAVFGATGLGLLIVAFDAFRVGTLLIGLAMLGGAALRWALPSVGMLAVRSRFTDIATYGGLGVAIVLLALMAQPHAWLKLPFLEDVLHFTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCK9</accession>
    <name>A0A2G1XCK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type VII secretion protein EccE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eccE</name>
        <name evidence="6" type="ORF">BLA24_22985</name>
        <name evidence="7" type="ORF">CYQ11_23090</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48973">
        <property type="protein sequence ID" value="PHQ48973"/>
        <property type="gene ID" value="BLA24_22985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15382">
        <property type="protein sequence ID" value="PPT15382"/>
        <property type="gene ID" value="CYQ11_23090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03923">
        <property type="entry name" value="T7SS_EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="426" mass="44802" checksum="2072B6B3C6680308" modified="2018-01-31" version="1">MAAATRIRAGSGPGAGADAVVPRPAQGRGALGPVRLQQLVLIEVAAALVLAAWAADQLLVLPAAVLAVVLLLLALVRRGSRPVTEWLTSAVALRRRERRAVPVTAGTDPRLAPVVECEPALRTESFTDRERRTVGLVGDGTFVSAVLRIETVDRPLRANRAEQALPLGLLRDAMDVDGIRLESVQVVQSALPAPAPHLPAQGLATRNYAPLQELTGSPAVRQTWVALKLDPELCAEAVEARGGGVEGARLCVLRAANQLASRLEGADFTATLLSEDALIAALATAADVNPAATAQAGRAGAPTRRTAETPRAWRCDDRWHTTYWVGRWPRLGGGAASLPQLAALLTSLPALSTTLSLTLGRGRNVDGLHAPTLTGHLRICGRSADELGTVRRELERAARGVKVGLVRLDHEQVPGVLATLPLGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM0</accession>
    <name>A0A2G1XCM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28035</name>
        <name evidence="4" type="ORF">CYQ11_17605</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48909">
        <property type="protein sequence ID" value="PHQ48909"/>
        <property type="gene ID" value="BLA24_28035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14442">
        <property type="protein sequence ID" value="PPT14442"/>
        <property type="gene ID" value="CYQ11_17605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304710" evidence="2">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="10184" checksum="D430AEAFCF7F4D0A" modified="2018-01-31" version="1">MHSKTMAATLLAGTAVLGTAGAAAADTPVDGAVKTVTGIVQNLPAGAPDLLGHGLATPTQKESKTKTLPAKVGQEHGASLPGAELLGGLPVGTGAVTGAVPGGMPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCU9</accession>
    <name>A0A2G1XCU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23070</name>
        <name evidence="3" type="ORF">CYQ11_23005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48989">
        <property type="protein sequence ID" value="PHQ48989"/>
        <property type="gene ID" value="BLA24_23070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15366">
        <property type="protein sequence ID" value="PPT15366"/>
        <property type="gene ID" value="CYQ11_23005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="281" mass="30442" checksum="FB437C8603B15AF7" modified="2018-01-31" version="1">MLTTTTTRVLDPGDLDAALAVLDRDPVANAFVAARVKIAGLDPWRLGGEMWGWYADGRLESLCYAGANLVPICAGPEAVRAFADRARRAGRRCSSIVGPDRATAELWSLLEPHWGPAREVRPHQPLMVTESMPPDVEPDPLVRRVRKDEMETIMPACVAMFTEEVGVSPMAGDGGLLYQARVAELVGSGRSFARVEDGRVVFKAEIGAATDRACQIQGVWVAPEHRGRGLSVTGMAAVLGYALREVAPVVSLYVNDYNTAARAAYRRVGFREVGAFMSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDE3</accession>
    <name>A0A2G1XDE3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_24620</name>
        <name evidence="7" type="ORF">CYQ11_21450</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49248">
        <property type="protein sequence ID" value="PHQ49248"/>
        <property type="gene ID" value="BLA24_24620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15100">
        <property type="protein sequence ID" value="PPT15100"/>
        <property type="gene ID" value="CYQ11_21450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="245" mass="26773" checksum="39EA22BCA75413F8" modified="2018-01-31" version="1">MEQTHISPGGAAATAGAQRRVLVVEDDRTIVDAISARLRAEGFQVRTAGDGPAAVDTAEAWQPDLLVLDVMLPGFDGLEVCRRVQAQRPVPVLMLTARDDETDMLVGLGVGADDYMTKPFSMRELAARVHVLLRRVERATLAAHTPRSGILRLGELEIDHAQRRVRVRGADVHLTPTEFDLLVCLANTPRAVLSREQLLAEVWDWADASGTRTVDSHIKALRRKIGAERIRTVHGVGYALETPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDJ1</accession>
    <name>A0A2G1XDJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24890</name>
        <name evidence="2" type="ORF">CYQ11_21180</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49298">
        <property type="protein sequence ID" value="PHQ49298"/>
        <property type="gene ID" value="BLA24_24890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15052">
        <property type="protein sequence ID" value="PPT15052"/>
        <property type="gene ID" value="CYQ11_21180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="18416" checksum="A1CA55E5C8D23174" modified="2018-01-31" version="1">MSHAVDAVDAAAIALNERSWTPSDYELTLARDFLTRRDGLPPRLLPGMPACPSPQGWVTQHVLWLEDVSHLADGLLAAWRDWLADGPMVALLAAYANLARSAVPLAAQLAQDWAAEWQAPPSAQETSWWEDWRLPAEQRRQIDALTDRLIMAGAVVVMAVNRGETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE48</accession>
    <name>A0A2G1XE48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25755</name>
        <name evidence="2" type="ORF">CYQ11_20315</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49449">
        <property type="protein sequence ID" value="PHQ49449"/>
        <property type="gene ID" value="BLA24_25755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14901">
        <property type="protein sequence ID" value="PPT14901"/>
        <property type="gene ID" value="CYQ11_20315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="189" mass="21679" checksum="4466C6A8F8F8427A" modified="2018-01-31" version="1">MDNIIATTTDNRFRVRLVPDEYARNPREDFDHLAHVITIDTHLGQYAHIDKDGGPFAEAWDRVSWNRWRGVAIFTRWARIFHGAIVIESRPARGPVSLWYLLREDAEDLGMLPEAYLDAERTEYEAWAEGDVYGYIVEEAVDWLRADADDTMSTWEEVDSCWGHYGYGWAAAQARAALEAHTSKTMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE50</accession>
    <name>A0A2G1XE50_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_25960</name>
        <name evidence="5" type="ORF">CYQ11_20105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49485">
        <property type="protein sequence ID" value="PHQ49485"/>
        <property type="gene ID" value="BLA24_25960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14864">
        <property type="protein sequence ID" value="PPT14864"/>
        <property type="gene ID" value="CYQ11_20105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IclR-ED" evidence="3">
        <location>
            <begin position="68"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="262" mass="28121" checksum="678BC0121340D41A" modified="2018-01-31" version="1">MGKGTAHGKKVFLVQRAFADLEGDSHGPTAIAKQTDLDAATVYRILQDGLADGTFVQEAGGRYRLGPGAFRLSMQALSQTPDPEATQAVLDKLQRMTGGLVAYYAVVGARRICTDYAIGDFDPRSIGIDPFELVKYSRSLRTGASGRVILAHMPPPIQEKVLAESVPEGVGPGVIRDNEALIESLKDIRAMGFAIGRQECMAGWDSVAVPVMWGDTIHGSLLLWVHVDKMPEDPSQLVAATMTAAEMLSRLASMPWAPESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE75</accession>
    <name>A0A2G1XE75_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26305</name>
        <name evidence="5" type="ORF">CYQ11_19335</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49544">
        <property type="protein sequence ID" value="PHQ49544"/>
        <property type="gene ID" value="BLA24_26305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14736">
        <property type="protein sequence ID" value="PPT14736"/>
        <property type="gene ID" value="CYQ11_19335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="3">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="233" mass="22948" checksum="E4FC5DBD97EE163C" modified="2018-01-31" version="1">MSAAADGGAAGRPVAGPARDAGQAFPLYVTAVAALLLLALAFFVVGRAGAVKNGAQTAADAAALAAAQDYREQLRAGFLAALGAGGDWAGWLAGTGAQTGPACRAAAAYAGLNDARPDIRCDPGEAPGSFTVTVTSARPVGRSVVPGTETRHAKATATAEVAPRCTAGPQPAPAPTPTAAPTRQPSPAPTGTPAPQPAQPVTLTCDDGPLVIDLQRAGAVVKATDLFTVHLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEB4</accession>
    <name>A0A2G1XEB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26455</name>
        <name evidence="2" type="ORF">CYQ11_19185</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49570">
        <property type="protein sequence ID" value="PHQ49570"/>
        <property type="gene ID" value="BLA24_26455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14711">
        <property type="protein sequence ID" value="PPT14711"/>
        <property type="gene ID" value="CYQ11_19185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="363" mass="39270" checksum="5E762AFFA20C7986" modified="2018-01-31" version="1">MEFLIILLALVVVCGFVVVPALRRRRAGEDALRGAGPAVDPAGAYGFAPPERLDVRLPGPDPELLTAVEEARRTQDWKPAADLLARTDATTAAELRWQRVQTLAGAAAAELAEAPGTGGMWLRHWRVVAPKDPGGAAVQAEFLVQQAMRDPSSQDYRMILEEARSVRAEAALLAPGDPVPAIVELGVARGLGASEAEFQSLWETVTARAPHHMGAHLSALRYWSAKWHGSRERAESFARAAAASAPQGSLLPALPLFAVFDHLPDVQLVRSLFQSAVIRDAVEAAQYAVNHAPEDHPVLPHVRHLLAWFLVRADRHGEALEQFRKIDGHIGALPWTYEQDPVAAYAAYRAIAVAGFEAGRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XED4</accession>
    <name>A0A2G1XED4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26570</name>
        <name evidence="4" type="ORF">CYQ11_19065</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49590">
        <property type="protein sequence ID" value="PHQ49590"/>
        <property type="gene ID" value="BLA24_26570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14691">
        <property type="protein sequence ID" value="PPT14691"/>
        <property type="gene ID" value="CYQ11_19065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="181" mass="19635" checksum="C3FEE3E7A71A0B5F" modified="2018-01-31" version="1">MRADARRNYERLLTEARTAFTAHGTDASLEDIAKRAGVGIGTLYRHFPNRTALMSAVFQGEVDGLLARSRELLASPEPCRALVAWLRAIVTHAGTYRGLSRALMAAQSDEASAMSRCSLPMREAGDTLLTRAKRAGAVREDVDIADLMQLTNAISLAAEQSPDDPELADRLLKLTLTGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI8</accession>
    <name>A0A2G1XEI8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26870</name>
        <name evidence="2" type="ORF">CYQ11_18765</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49640">
        <property type="protein sequence ID" value="PHQ49640"/>
        <property type="gene ID" value="BLA24_26870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14638">
        <property type="protein sequence ID" value="PPT14638"/>
        <property type="gene ID" value="CYQ11_18765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="209" mass="23267" checksum="FD8080CB97247667" modified="2018-01-31" version="1">MPTSKHSPASCPPDSGVDEAIDWDAVEAEWGTRLPSDYQAFMATYGCGSIWDLGILRPLPYKGRPTQWFSTIADETPTIRHLWDESVAALGTGLGADAVLPWGDGCNGALMGWLTNSPDPDQWPVVVWARHGSPRWTLHTCGMAAFLRRLLLTEFDTNPLSDDTLWGNVEPFVHWREAQRRYFAGLDTLTGEPDPYADMYPADPREFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEJ6</accession>
    <name>A0A2G1XEJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26880</name>
        <name evidence="2" type="ORF">CYQ11_18755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49642">
        <property type="protein sequence ID" value="PHQ49642"/>
        <property type="gene ID" value="BLA24_26880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14636">
        <property type="protein sequence ID" value="PPT14636"/>
        <property type="gene ID" value="CYQ11_18755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="119" mass="13206" checksum="D9B157D92F0D364B" modified="2018-01-31" version="1">MHDRPTPHPDPEAPMTYREGTYVIDTRHERLAQVMGMVGPRVQVRRPGGGREWEVPPEVLRLATREERAAGGGCAECGRLRAAQRRAVDRGAKREAVAATVAVRHHLRDAHAETEDGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEN1</accession>
    <name>A0A2G1XEN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23185</name>
        <name evidence="4" type="ORF">CYQ11_22890</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49688">
        <property type="protein sequence ID" value="PHQ49688"/>
        <property type="gene ID" value="BLA24_23185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16735">
        <property type="protein sequence ID" value="PPT16735"/>
        <property type="gene ID" value="CYQ11_22890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758438" evidence="2">
        <location>
            <begin position="27"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="38471" checksum="10D35E54708E67ED" modified="2018-01-31" version="1">MRRLLVAVAAAAVGFLLLSALGYAVAHPKATHESVVRLLWCAVPLAAAVQFAVAVARTDPATRPRDGMDAIGFGPVRLSFLAAASTALTCGLGGAAALLAYLELRGDLGGTPLSGAAAGALDADAPLPWAGALTLLGLLPALASGACVLALRPRGRLRSGRAASRRGTPPAPREPSRGYAGLPWGVAVIACGLALEAYVGRAPAPAPDRLLTLPGQEGGTSPALLGGWLLASLGLVVAGPGLTHWSGALLAAGRPGPVRMLAGRILQEAAKPLGRPLGVLCAVASGALAAVQLYGTAWDRSGPGPFGPLTGLGAAVVMACATATAVTAALDTRRSRARTAAALLRLGIPTSLLRGAAAVRACVLLAVLAPLTWVIAELTTLPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEP2</accession>
    <name>A0A2G1XEP2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sulfate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27055</name>
        <name evidence="7" type="ORF">CYQ11_18575</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49671">
        <property type="protein sequence ID" value="PHQ49671"/>
        <property type="gene ID" value="BLA24_27055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14606">
        <property type="protein sequence ID" value="PPT14606"/>
        <property type="gene ID" value="CYQ11_18575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="95"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="298" mass="31192" checksum="F0CEF7CBEFDFEE32" modified="2018-01-31" version="1">MASTDTPPQATPEGDLAGLGAGLDALDTAPPDHTPLRQVLLHKVLPPVAAVALVLATWKLLVLAGVADDYKLPDPTAVWRSLRELWLQGTLFDIIWTSLSRGLLGFLAALALGTPLGLLIARLPLLRAALGPLLSGLQSLPSVAWVPAAVIWLGITDTAMYAVILLGAVPSIANGLVSGIDQVPPLYLRAGHTMGATGLRATRHVLLPAALPTYIAGLKQGWAFSWRSLMAAELIASSPELGLGLGQYLDNARTDSDMPAVLAGIILILLVGIAIDLIVFSPLERRVLRARGLLAGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF01</accession>
    <name>A0A2G1XF01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19230</name>
        <name evidence="3" type="ORF">CYQ11_11570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49785">
        <property type="protein sequence ID" value="PHQ49785"/>
        <property type="gene ID" value="BLA24_19230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13439">
        <property type="protein sequence ID" value="PPT13439"/>
        <property type="gene ID" value="CYQ11_11570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="22086" checksum="1F0F15B478996520" modified="2018-01-31" version="1">MEPISLKTDRLVLRPFAPSDAPAVHAACQEPDIPRYTSAPSPYTPEHARVFVEDTCPKGWREDSLYTFGLFTRDDAQRLVGSMCLVRLALSTPERQAELGYWTAKEQRGRGYTVEAAREVVRWSFADLGVERMEWYAEAGNEASRAVALKIGFRMEGTMRAKIPYNGTRRDAWVGSLLPSDLGLPTDAAYLPFPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF42</accession>
    <name>A0A2G1XF42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_19630</name>
        <name evidence="9" type="ORF">CYQ11_11165</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49854">
        <property type="protein sequence ID" value="PHQ49854"/>
        <property type="gene ID" value="BLA24_19630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13370">
        <property type="protein sequence ID" value="PPT13370"/>
        <property type="gene ID" value="CYQ11_11165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="54"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="21026" checksum="E7C62FC7E80EA392" modified="2018-01-31" version="1">MSTDQPEQPPDDDPFRKRPPEPGAQPPPYPGAAAGGGGASFGAPDPLAGMPPLASRFKRLIARIVDGLLVSIPVSAVFYGAYWGHHPWNDQGRSTGLGIIISVVYFVYEGLMLTSRGQTVGKMLMKIRVGMLENGAIPAGTPGWTRAAVYSLPQIVPCCGFVFWLVNVLWCTWDEPYHQCLHDKAAKTVVVSAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF72</accession>
    <name>A0A2G1XF72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation protein SsgA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SsgA family sporulation/cell division regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19615</name>
        <name evidence="5" type="ORF">CYQ11_11180</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49851">
        <property type="protein sequence ID" value="PHQ49851"/>
        <property type="gene ID" value="BLA24_19615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13373">
        <property type="protein sequence ID" value="PPT13373"/>
        <property type="gene ID" value="CYQ11_11180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="138" mass="14760" checksum="2A5D725292E9C529" modified="2018-01-31" version="1">MHIVVERSLDLDMVLSAGRSIPVPARLSYRSADPLAVHITFHVRSDRPVTWTFARDLLVEGVFRAVGEGDVRVFPGMEAGRAVVGVALSSPEGRALLRAPAGPLAQWLERTLRAVPAGAERGWLALDEGLAELLASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF96</accession>
    <name>A0A2G1XF96_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19985</name>
        <name evidence="3" type="ORF">CYQ11_10805</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49912">
        <property type="protein sequence ID" value="PHQ49912"/>
        <property type="gene ID" value="BLA24_19985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13313">
        <property type="protein sequence ID" value="PPT13313"/>
        <property type="gene ID" value="CYQ11_10805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="194" mass="20572" checksum="198F1F46CD57BACF" modified="2018-01-31" version="1">MSSRTYETHHGPRPAHHRPASAFVTLPGSDWLASASRFPRSVHALWAESPLSTVVLPCGTVFDVISAPALFGRRMLDRLWAPSGPGTGPVAAQRDRLLLFAAPGTAQRLPALLGWEEWGRGGRAAPPLLYFGTGDAVTVPPPCPAPEEAEPQPPASRWLVAPESRDPWLPGADVLLWACVRAARAGGVPKGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFH7</accession>
    <name>A0A2G1XFH7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20510</name>
        <name evidence="2" type="ORF">CYQ11_10270</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49996">
        <property type="protein sequence ID" value="PHQ49996"/>
        <property type="gene ID" value="BLA24_20510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13226">
        <property type="protein sequence ID" value="PPT13226"/>
        <property type="gene ID" value="CYQ11_10270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="24673" checksum="EF94D7E3F4BD000B" modified="2018-01-31" version="1">MTQRLSFADAGEAADLAAFLARLIHYDRAAAVRLQAGGGVLGVFGRPPSFEVLAIRTARLTGHALLDVTVSAGRLADAIDGGSPLPDGGLEVTVPETVTGPPWAGVLPPRGGWRRVPGLPGTEAVRGAVSAAVAEFRARDKALPEQRRTRAERDRMGREIWSRTLGETGLPLRAVHAAQSLGFLRPVPAQAGAGGGVPSPSGALDLFAARGWLRLRTPYGSIAVSTGGGLRDLTVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFP8</accession>
    <name>A0A2G1XFP8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">BLA24_20800</name>
        <name evidence="5" type="ORF">CYQ11_09980</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50047">
        <property type="protein sequence ID" value="PHQ50047"/>
        <property type="gene ID" value="BLA24_20800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13174">
        <property type="protein sequence ID" value="PPT13174"/>
        <property type="gene ID" value="CYQ11_09980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="21072" checksum="2C07A6A92649725A" modified="2018-01-31" version="1">MPSAAGEIAIGGGLGDQVYNRLLGERIIFLGQQVDDDIANKITAQMLLLAADPTKDIYLYINSPGGSVTAGMAVYDTMQYIPNDVVTIGMGLAASMGQFLLTGGTAGKRFALPNTDILMHQGSAGLGGTASDIKIQAEQLLRTKKRMAEITAAHTGQTVETIIRDGDRDRWFTAEEAKEYGIIDEIITHASGVPGGGGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFX0</accession>
    <name>A0A2G1XFX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21355</name>
        <name evidence="4" type="ORF">CYQ11_09430</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50134">
        <property type="protein sequence ID" value="PHQ50134"/>
        <property type="gene ID" value="BLA24_21355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13085">
        <property type="protein sequence ID" value="PPT13085"/>
        <property type="gene ID" value="CYQ11_09430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304769" evidence="2">
        <location>
            <begin position="32"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="337" mass="35466" checksum="4D69C0B9807611C1" modified="2018-01-31" version="1">MNVRPIRSRRTPAAATALAAVLGLVTLSACAVDGGSGRDKDGKLRVVASFYPMEFLAKEIGGEHVAVTGLTKPGVEPHDMELTARQTGSLADAGTILYLKGVQPAVDKAVKQSGNKHAVDAASLTALTKHGGEVDGRHHTTGDNGAGDGHDEDEEHGGHEHEEGGADPHIWLDPVKYAEVARGVGKALADADPGHAADYETNAHALIEKLGALNTKFADTLKNRGSDTFITTHAAFGYLADRYGLVEEAISGLDPESEPSAARMKDLHKLAGEHHVGTVFFETLANPGTAKTFAQDLGLKTDVLDPLEGITKDSRGRDYFGVMEANLTALQKALGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFY3</accession>
    <name>A0A2G1XFY3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="10" type="ORF">BLA24_20810</name>
        <name evidence="11" type="ORF">CYQ11_09970</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50049">
        <property type="protein sequence ID" value="PHQ50049"/>
        <property type="gene ID" value="BLA24_20810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13172">
        <property type="protein sequence ID" value="PPT13172"/>
        <property type="gene ID" value="CYQ11_09970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="428" mass="46877" checksum="E8232D0B5BC5E11E" modified="2018-01-31" version="1">MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRWEELPKPREIYEFLEGYVVGQEAAKKALSVAVYNHYKRVQAGENGGHNRDDGIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFSGLEKIIESRAGAKGIGFGATIRSKREIEASDQFQEVMPEDLVKFGMIPEFIGRLPVITSVHNLDREALLQILVEPRNALVKQYQRLFELDGVELDFDRPALEAIADQAILRGTGARGLRAIMEEVLMSVMYEVPSRKDVARVVITADVVQSNVNPTLVPRTRGNEPGERHEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG16</accession>
    <name>A0A2G1XG16_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_21425</name>
        <name evidence="16" type="ORF">CYQ11_09360</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50145">
        <property type="protein sequence ID" value="PHQ50145"/>
        <property type="gene ID" value="BLA24_21425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13072">
        <property type="protein sequence ID" value="PPT13072"/>
        <property type="gene ID" value="CYQ11_09360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="65"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="299"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="12">
        <location>
            <begin position="424"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="14">
        <location>
            <begin position="539"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="856"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="792"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="905" mass="98301" checksum="016D5179E55E5801" modified="2018-01-31" version="1">MPVTEDRQKFVYDFTEGNKDLKDLLGGKGANLAEMTNLGLPVPPGFTITTEACKVYLEGGEEPLSMRDEVSAHLAALEERMGKKLGQADDPLLVSVRSGAKFSMPGMMDTVLNIGLSDASVAGLATQAGDERFAWDSYRRLIQMFGKTVLGVDGDLFEEALEEAKHTKGVSTDVELDAADLKRLVEGFKAIVAQETGRDFPQDPREQMDLAIRAVFDSWNGDRAKLYRRQERIPGDLGTAVNVCSMVFGNLGPDSGTGVAFTRDPASGHQGVYGDYLQNAQGEDVVAGIRNTMQLAELEQLDKASYDQLMQIMETLETHYRDLCDIEFTIERGKLWMLQTRVGKRTAGAAFRIATQLVDQGLIDEAEALQRVSGAQLAQLMFPRFDEKATTELLGRGIAASPGAAVGKAVFDSYTAVKWSRSGEKVILIRRETNPDDLDGMIASEGILTSRGGKTSHAAVVARGMGKTCVCGAEELEVDTKRRRMTAPGGVVVEEGDVVSIDGSTGKVYLGEVPVVPSPVVEYFEGRMHAGADDADELVQAVHRMMAYADRTRRLRVRANADNAEDASRARRFGAQGIGLCRTEHMFLGERREMVERLILADTEAERDEALGALLPLQKADFVELFEAMDGLPVTVRLLDPPLHEFLPDITELSVRVALAEARQEAHENELRLLQAVHKLHEQNPMLGLRGVRLGLVIPGLFAMQVRAIAEAAAQRLGSGGDPRAEIMIPLVGTVQELEIVREEAERVIADVEAATGTDLKLTLGTMIELPRAALTAGQIAEAAEFFSFGTNDLTQTVWGFSRDDVEASFFTAYLEKGIFGVSPFETIDRDGVGSLVRAAVQAGRATRPDLKLGVCGEHGGDPESVHFFHEVGLDYVSCSPFRIPVARLEAGRAAALNGTASDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGF9</accession>
    <name>A0A2G1XGF9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22520</name>
        <name evidence="3" type="ORF">CYQ11_08270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50323">
        <property type="protein sequence ID" value="PHQ50323"/>
        <property type="gene ID" value="BLA24_22520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12890">
        <property type="protein sequence ID" value="PPT12890"/>
        <property type="gene ID" value="CYQ11_08270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="65" mass="7540" checksum="040650B4C11ACEBD" modified="2018-01-31" version="1">MSRLLPTRYLTPIDVADLLGVPVETVYQWRRKRTGPCGFRVGRHLRYDPEDVRVWITSLINGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGH5</accession>
    <name>A0A2G1XGH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_22670</name>
        <name evidence="6" type="ORF">CYQ11_08120</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50348">
        <property type="protein sequence ID" value="PHQ50348"/>
        <property type="gene ID" value="BLA24_22670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12864">
        <property type="protein sequence ID" value="PPT12864"/>
        <property type="gene ID" value="CYQ11_08120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="227" mass="23926" checksum="B5875218C39A6655" modified="2018-01-31" version="1">MTEPITVLLADDQALLRSAFKVLVDSEPDMRVVAEAADGAEAVELARRHVPDVVLMDIRMPGTDGLAATRAICTDPALAAVRVVMLTTFEVDEYVVQSLRAGASGFLGKGAEPDELLAAIRVAAAGEALLSPAATKGLITTFLAQGEERGRPAGPAARLDALTVREREVLVHVAGGLSNDEIGERLAVSPLTVKTHVNRTMAKLGARDRAQLVVAAYESGLVRPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGQ2</accession>
    <name>A0A2G1XGQ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21415</name>
        <name evidence="4" type="ORF">CYQ11_09370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50407">
        <property type="protein sequence ID" value="PHQ50407"/>
        <property type="gene ID" value="BLA24_21415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13073">
        <property type="protein sequence ID" value="PPT13073"/>
        <property type="gene ID" value="CYQ11_09370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="2">
        <location>
            <begin position="125"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="335" mass="37093" checksum="B1766DCF253373E9" modified="2018-01-31" version="1">MTLDTPAVATPPAKAPAVDTADGIRRRELALFLRSRRERITPEQVGLPRGPRRRTPGLRREEVAQLAAVGVTWYTWLEQARDIQVSVQVLDSVARALLLDRGERAHLFALAGVVDPQPGTDSPSVTPELRAMLRALEPLPASVQNARYDILAYNRTYGRLMCDLDALPPENRNCLWLHFTDPVWLANALNGAEARRSMAAKFRASMAEHIAEPAWKCLLKRLLDASPEFRELWARHEVIPVDDQKAAILRHPRVGLLRLDHTSLWTGPVPGTRLITFTPADEDTRAGLERLHALALAEQHASAAPQSGPRPAGDLRPMKGLGRMGDNGRSAQPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGR7</accession>
    <name>A0A2G1XGR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22180</name>
        <name evidence="2" type="ORF">CYQ11_08605</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50426">
        <property type="protein sequence ID" value="PHQ50426"/>
        <property type="gene ID" value="BLA24_22180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16430">
        <property type="protein sequence ID" value="PPT16430"/>
        <property type="gene ID" value="CYQ11_08605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="29800" checksum="89AA4FEA3FB4F26C" modified="2018-01-31" version="1">MCPPTYFRVTYSINPWMDPGKPVDLPLALAQWEELRDRYRSLGHTVEELVPRPGLPDMVFAANGATVVDGRVLGARFTHPERWEEAAAHLAWFRSHGYARVREPQHINEGEGDFAVTASWLLAGRGFRSSPLSHPEAQEFFGRPVIGLDLVDPRYYHLDTALCVLDDSTDGEIMYYPGAFSPGSRAVLERLFPDALVASEEDAMALGLNAVSDGRHVLLPQGAVGLFEPLRARGYEPVGMDLGELLKGGGSVKCCTQELRGDPAGPGGTGTAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH14</accession>
    <name>A0A2G1XH14_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_17040</name>
        <name evidence="7" type="ORF">CYQ11_16240</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50530">
        <property type="protein sequence ID" value="PHQ50530"/>
        <property type="gene ID" value="BLA24_17040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14216">
        <property type="protein sequence ID" value="PPT14216"/>
        <property type="gene ID" value="CYQ11_16240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="31042" checksum="9EE49B7ADCD1DC54" modified="2018-01-31" version="1">MYRFLLTPRWWGINVFTALAIPVCLFMGSWQLGRFETRVDTHREQQAQTDEARTADAAPLRDLLPVTTETSGRQASVTGRYDTDHQLLVPDRDLDERKGFYVLTLLRTDGGKAVPVVRGWLPGDAGSKDDSAKVPAPPSGQVTVTGALQSSESPTSKGVRASGGLPAGQLGVISAASLVNLVPYEVYDAWITVSKAASPLTAVPPATAPGSGLDLKAFQNLGYTGEWFVFAGFTLFMWFRLFRREAEAARDLELGITPEDPEGPAQPGRPENPEGSDDGPQTRSPAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH65</accession>
    <name>A0A2G1XH65_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_17405</name>
        <name evidence="11" type="ORF">CYQ11_15870</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50584">
        <property type="protein sequence ID" value="PHQ50584"/>
        <property type="gene ID" value="BLA24_17405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14161">
        <property type="protein sequence ID" value="PPT14161"/>
        <property type="gene ID" value="CYQ11_15870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="9">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF35_N" evidence="8">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="7">
        <location>
            <begin position="231"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="372"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="494" mass="51416" checksum="1E6E11BEBB051462" modified="2018-01-31" version="1">MSDDAARDPESDALYARLKAYEGSPAAVSGRGRDPVNAPMIRHWCEVMGHTDPACAGPDPVAPPAMLQAWTMGGLSGRPEGRPAAYGELLTLLDEAGCTAVIATDCEQEYLRPLRPGDEITFDAVLESVSPRKTTRLGTGHFITTRTEIQANGRLAGTHRFRILKYAPRPPAPPAAPAERPRPVVNRDNAGFWEGVAAHTLLIQRCDACGTPRFPWLPGCGSCGSPQWTAVEASGDGSVYSYVVVHHPAAPGFEPPYAVGLVELAEGVRMISNVVGVAPDEVRVGMPVRLEFAEADGLTLPLFRAGPGALPRGVRTATPPTATAGTTTAGTATACAAPSPARTADRTPASPVPPGAPASPVPRAWAPGDVLAPLTVPVTRTLIVAGALASRDYQDVHHDPEAARAKGAPDIFMNILTTNGLVGRFLTERLGPGAVLRALAVRLGVPNYPGDELVLTGSVTSVAGAGLRVALAGTNRLGRHVTGTATVALPGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHA4</accession>
    <name>A0A2G1XHA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17660</name>
        <name evidence="4" type="ORF">CYQ11_15615</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50624">
        <property type="protein sequence ID" value="PHQ50624"/>
        <property type="gene ID" value="BLA24_17660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14121">
        <property type="protein sequence ID" value="PPT14121"/>
        <property type="gene ID" value="CYQ11_15615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="40"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="174"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="429"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="526" mass="55907" checksum="463897F075C24928" modified="2018-01-31" version="1">MHSLDAATEATRSLQGLSTELTGRVPQLLEAMRSVGTGLELRTTLDRIAETAAELADATYAAIGVLDPGGEGLSDFITYGVARDQYEHVAAFPDGQHALSVPIRVGGEIFGNLYLTEKRRGGEFDIADLHMVKILATEAGIAIGNARVHEERGQRMRWIDGSVAVTTALLSGSDAEDALSVVAEQARRLADSAAGIVLLPDNEGGLEMVAVSAEDPTGLLGTVMPPHSPVVSQLLAGEPVFIDDSATDPRMITEVAPRFGPSMLLPLKSGTRVLGTLATPRRRGARKYTDTERTLATQFAAQAALALVLAEAQRDRERLAVYEDRDRIARDLHDLVIQRLFATGLLLERAQRLAVVPEVQTKVGQAVDELDVTIQEIRTAIFALQQEPTEAPAGLRTRVLRELGTAAVPLGFQPSATFVGPVDAKVGERTGKNLIAALREALSNAFRHARASRIEVLVDATVTLPDGREGVRLTVADDGVGIPEGGRRSGLRNLAKRAESLGGSSSYGPGIGEDGGGTKVVWEAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHG1</accession>
    <name>A0A2G1XHG1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="13" type="ORF">BLA24_17700</name>
        <name evidence="14" type="ORF">CYQ11_15575</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50631">
        <property type="protein sequence ID" value="PHQ50631"/>
        <property type="gene ID" value="BLA24_17700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14114">
        <property type="protein sequence ID" value="PPT14114"/>
        <property type="gene ID" value="CYQ11_15575"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ThiC-associated" evidence="12">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ50631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="586" mass="64983" checksum="85C6A9445313A65F" modified="2018-01-31" version="1">MTSQDARTSENGREIGWHKDYVTGSRPDLRVPVRRVHLTNGQDVQLYDTSGPYTDPDVETDVRRGLLPLRENWIIARGDTEEYAGRPMRPEDDGIKHTSPRGGLKNLDAVFPGRPRQPRRGRAGAAVTQLAYARRGEVTAEMEYVALRENVSPETVREEIAAGRAVLPANVNHPEIEPMIIGKKFLVKVNANIGNSAVTSSIEEEVEKMTWATRWGADTVMDLSTGRNIHTTREWVLRNSPVPIGTVPLYQALEKVDGKAEELTWEIYKDTVIEQAEQGVDYMTVHAGVLLRYVPLTARRKTGIVSRGGSIMAAWCLAHHKESFLYENFEELCEILAAYDVTYSLGDGLRPGSIADANDEAQFAELKTLGELNTIAKRHNVQTMIEGPGHVPMHKIKENIDLQQEICEEAPFYTLGPLTTDVAPAYDHITSGIGAAMIAWWGTAMLCYVTPKEHLGLPDRDDVKTGVITYKIAAHAADLAKGHPGAQEWDDALSDARFEFRWEDQFNLALDPDTARAFHDETLPAEPAKTAHFCSMCGPKFCSMKISQDIRREHGGDLAVDVEAGMAQKSEEFAAAGNRVYLPIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHI3</accession>
    <name>A0A2G1XHI3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17510</name>
        <name evidence="3" type="ORF">CYQ11_15765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50599">
        <property type="protein sequence ID" value="PHQ50599"/>
        <property type="gene ID" value="BLA24_17510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14146">
        <property type="protein sequence ID" value="PPT14146"/>
        <property type="gene ID" value="CYQ11_15765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17245" checksum="128B94C1BE72CA88" modified="2018-01-31" version="1">MSIWWSLHLRREAASVPLARRLLIGAMETAGVDPETSYDLAVALSEACANAVEHGGDASTGYRVTALIDGDTCRIEVTDSGPGFADRPRRPRRHTARTAYVKAPASVHEEHGRGLFLIASLTDHVQVDNRPGHQGAVVSFDKILKWREGGPPAAALLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHQ3</accession>
    <name>A0A2G1XHQ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18430</name>
        <name evidence="3" type="ORF">CYQ11_14850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50756">
        <property type="protein sequence ID" value="PHQ50756"/>
        <property type="gene ID" value="BLA24_18430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13986">
        <property type="protein sequence ID" value="PPT13986"/>
        <property type="gene ID" value="CYQ11_14850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="8204" checksum="D84DE95754840CB6" modified="2018-01-31" version="1">MDRGVSDEIPLSTYAVDMRTGRLGQVMDHHAGYVQLRPPRGGLEWNCPPEHARPAADPTAPEEAGAGSGAESGRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHR9</accession>
    <name>A0A2G1XHR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18500</name>
        <name evidence="2" type="ORF">CYQ11_14780</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50766">
        <property type="protein sequence ID" value="PHQ50766"/>
        <property type="gene ID" value="BLA24_18500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13976">
        <property type="protein sequence ID" value="PPT13976"/>
        <property type="gene ID" value="CYQ11_14780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="230" mass="25010" checksum="445AA12B21F64A93" modified="2018-01-31" version="1">MAAPLSRIRLAAVNIDGVLLNDTFSPVIHDFVTSRGGRYTADVERAVFSQTQLVAAAALADAAGVDWTPERVLEVYFQERAAYLEKDPIRILDGAVDLLHRLRALGLRTVCYGGLTAEHFDRYLGEHADLFDGPGYVCTNDFRPGIAEITGDVFGLRPDEALFIDDVARVAETARSLGVAFIGHPSGFAHGFQGELMRAAGVRHVVETLSAIDEELLRTVDAEARAGTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHV2</accession>
    <name>A0A2G1XHV2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_18845</name>
        <name evidence="6" type="ORF">CYQ11_14435</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50822">
        <property type="protein sequence ID" value="PHQ50822"/>
        <property type="gene ID" value="BLA24_18845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13920">
        <property type="protein sequence ID" value="PPT13920"/>
        <property type="gene ID" value="CYQ11_14435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="324" mass="35060" checksum="5EDA7F2E8E4C9F46" modified="2018-01-31" version="1">MNHGDGVIEVSELRRRYGRPGDDKGFDAVRDVSFTVRRGELFALLGTNGAGKTSTVELLEGLARPTAGRVRVLGHDPHGERSLVRPRIGVMLQEGGFPSDLTAAETVRMWAGCTTGARPVAEALGLVGLTGRRDVRIKQLSGGERRRLDLALALLGRPEVLFLDEPTTGLDPEARHTTWELVRRLREEGTTVLLTTHYLEEAEALADRLAIMREGRIVSSGTPGEVIGAYPARIRFAMPAGWFVGDLPPLKDLGVLRHEEAGGRVELQTSELQRTLTGLLLWAREKDVELEGLDARTASLEEAFLAIAGAAGTPAPLAVTGRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI01</accession>
    <name>A0A2G1XI01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19065</name>
        <name evidence="4" type="ORF">CYQ11_14215</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50853">
        <property type="protein sequence ID" value="PHQ50853"/>
        <property type="gene ID" value="BLA24_19065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13888">
        <property type="protein sequence ID" value="PPT13888"/>
        <property type="gene ID" value="CYQ11_14215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="233"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="582" mass="61562" checksum="95465FF30CC81352" modified="2018-01-31" version="1">MNFTRWSARLPGTQRRAAARADRTSATSSQVPATTGAQGTGSVPAARAESAPAAGPDADPVPSLDALSVHAILGQVPALVAVLYGPDHRVAYVNDAYAALFGPRTPGIPARTALPELDELGLLPLMDQVLRSGRPRTVKSRRVPLTAPAGAPAPARTDPDARPRHGYYTFTCSPLEVGGSTAAQRGVLVFAADVTDQVEAAERLRASERRQREAAVTLQRSLLPQELEQPDDLRVAATYQPGGKDTAVGGDWYDVITLGAGRTALVIGDVMGRGVRAAAVMGQLRTAVRAYARLDLPPHEVLQLLDGLAAEIDATQIATCVYAIHDPNEGRLVYASAGHLPILVRDPDGTVRRAAEPTGPPLGTGGWLHTSGSMPFGPGASAVLYTDGLVERRDEDIDEGVAALERAFAGATGSPQVMCDRLIRALGVTQEHDDDVAVLVLQHPARTGHDAELFHNAALELLGGIEAAPRARAFASGVLASWRFPTDLRDLGVLAASELVANSLQHGTPPMRLRLRRTDRRLIIEVTDGDDHLPRRRRAEPADEAGRGISIIATIASSWGSRRTPGGGKAVWCEFALPAGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI50</accession>
    <name>A0A2G1XI50_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18410</name>
        <name evidence="2" type="ORF">CYQ11_14870</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50903">
        <property type="protein sequence ID" value="PHQ50903"/>
        <property type="gene ID" value="BLA24_18410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16572">
        <property type="protein sequence ID" value="PPT16572"/>
        <property type="gene ID" value="CYQ11_14870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="19193" checksum="E8A989CADE7E1D5D" modified="2018-01-31" version="1">MPDGRTIPALTADERTTLESWLAFHRATLAHKCTGLTDDQARTAAAPPSRLSLLGLVQHMTEVERVWFRRVLLKEAVPLVHGPDRTPKRLEDMDETSGGFEVDDDATLAGALAAWRAETATADANAAPLPLDATGEALGKKVSLRWIYVHMIEEYARHNGHADLLRERVDGSAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI51</accession>
    <name>A0A2G1XI51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18755</name>
        <name evidence="2" type="ORF">CYQ11_14525</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50809">
        <property type="protein sequence ID" value="PHQ50809"/>
        <property type="gene ID" value="BLA24_18755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13933">
        <property type="protein sequence ID" value="PPT13933"/>
        <property type="gene ID" value="CYQ11_14525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="30228" checksum="DA843444B821447E" modified="2018-01-31" version="1">MSAADPTGQQLLVVIDPVARRVDGESTRIAKDVLCAGSVAKICLPNGPEEVARALARRGRRRTVVIGDDRALLRVVGLLHRRRELGDAPLAWVPVGTLPAVSVARVLGVPLGAVAAARAVLDGAERSLDLLADDVDGVVLGGLWVPAGGSRSEPAAAPLADVPAGGVHHAWWTPAARTARTALTLLSGPSGRHPLPACTRLRIEADGVLLADVDRPVGRVAVAAVEGLAEVAVQHRTGDEPVRARARAVTVSGPDFRYRADNRIRGPVRARTWTALPEAWRLTLPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIE5</accession>
    <name>A0A2G1XIE5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoK</name>
        <name evidence="7" type="ORF">BLA24_14495</name>
        <name evidence="8" type="ORF">CYQ11_13580</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50997">
        <property type="protein sequence ID" value="PHQ50997"/>
        <property type="gene ID" value="BLA24_14495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13781">
        <property type="protein sequence ID" value="PPT13781"/>
        <property type="gene ID" value="CYQ11_13580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="121" mass="12917" checksum="E0A997F0D7653008" modified="2018-01-31" version="1">MHLVYAAVLAALLFCVGLYGVLARRNAILVLMSVELMLNAVNLNLVAFDVWLRDTLHAGQALTLFTIAIAAAEIGIGLAIVLLVYRNRGTADVDRLRDLNEDTPAPGTASADRDEKAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIF7</accession>
    <name>A0A2G1XIF7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">BLA24_14760</name>
        <name evidence="7" type="ORF">CYQ11_13310</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019888756.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51038">
        <property type="protein sequence ID" value="PHQ51038"/>
        <property type="gene ID" value="BLA24_14760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13739">
        <property type="protein sequence ID" value="PPT13739"/>
        <property type="gene ID" value="CYQ11_13310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="10632" checksum="E316ED834424BF12" modified="2018-01-31" version="1">MSEKNVTETNERGFRKTREGLVVSDKMDKTVVVAVEDRVKHALYGKVIRRTNKLKAHDEQNAAGVGDRVLLMETRPLSATKRWRVVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM5</accession>
    <name>A0A2G1XIM5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">groL</name>
        <name evidence="9" type="synonym">groEL</name>
        <name evidence="12" type="ORF">BLA24_15025</name>
        <name evidence="13" type="ORF">CYQ11_13045</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51086">
        <property type="protein sequence ID" value="PHQ51086"/>
        <property type="gene ID" value="BLA24_15025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13691">
        <property type="protein sequence ID" value="PPT13691"/>
        <property type="gene ID" value="CYQ11_13045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="541" mass="56772" checksum="8107075C7051FE5F" modified="2018-01-31" version="1">MAKTLKFDEDARRALERGVNKLADTVKVTIGPKGRNVVIDKKFGAPTITNDGVTIAREVELDDAYENLGAQLVKEVATKTNDIAGDGTTTATVLAQALVREGLRNVAAGASPAALKKGIDAAVKAVSDDLLATARPIADKADIAAVAALSAQDKQVGELIAEAMDKVGKDGVITVEESNTFGLELDFTEGMAFDKGYLSPYMVTDQERMEAVLDDPYILIHQGKISSIQDLLPLLEKIIQAGGSKPLLIIAEDVEGEALSTLVVNKIRGTFNAVAVKAPGFGDRRKAMLGDMATLTGATVIAEEVGLKLDQAGLDVLGTARRVTITKDDTTIVDGGGKSEDVAGRVAQIKAEIETTDSDWDREKLQERLAKLAGGVCVIRVGAATEVELKEKKHRLEDAISATRAAVEEGIVSGGGSALVHAAKVLEGGLDKVGDEATGVAVVRRAVVEPLRWIAENAGLEGYVITSKVAELEKGQGFNAATGEYGDLVKAGVIDPVKVTRSALENAASIASLLLTTETLVVEKKEEESEAGHGHGHGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ73</accession>
    <name>A0A2G1XJ73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15990</name>
        <name evidence="3" type="ORF">CYQ11_12085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51250">
        <property type="protein sequence ID" value="PHQ51250"/>
        <property type="gene ID" value="BLA24_15990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13524">
        <property type="protein sequence ID" value="PPT13524"/>
        <property type="gene ID" value="CYQ11_12085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304752" evidence="1">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="22145" checksum="B77196632EDB8D78" modified="2018-01-31" version="1">MFRRRTALSVSTAAGLLAAVPLLTACGSTAHPGAAAVVGKDRITVSQLQGEVEDVREAQRSSPQGQQLLANSARLGQDTLIRLVQDRIVAQAGRDHGVEVTRRELQEQRTRVEKANGGAAATEDRFLALGIAPDRIDQALAMDLTHSKLNDKLGTARANQVLAQTSDALHVDVNPRYGTWDARRGTARTVLDPWLRPAAPPVPGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJA1</accession>
    <name>A0A2G1XJA1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LytR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_16330</name>
        <name evidence="7" type="ORF">CYQ11_11745</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51306">
        <property type="protein sequence ID" value="PHQ51306"/>
        <property type="gene ID" value="BLA24_16330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13468">
        <property type="protein sequence ID" value="PPT13468"/>
        <property type="gene ID" value="CYQ11_11745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="160"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="426"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="593" mass="62438" checksum="4B102405D198A0F8" modified="2018-01-31" version="1">MRHSSGVRGDQADKADKSGDNTEEAKGSTDSKDPDDAEGPGGTGKPKRAAGREADGSGSISGGGSPRRRRLKRIARWSALGLALLVLGVSAAGYLYYEHLNGNIKKNKLNLGDKQLDRSAANADGQRPLNILLLGSDSRNSKENQDLGGARDDADRPPLADVQMLVHVSADRSNMSVISVPRDTRVTIPKCTDPDNGKVYKETNRQIINTSLGNGGPGCTVATWEELTGIPIDHFMMIDFAGVVSMADAVGGVPVCVDSNVYDSKSGLRLSKGSQTVKGEQALQWLRTRHGFEDGSDIGRTHAQHMYMNAMVRQLKGGTKLSDPGQLTDLAEAATRALTVDKDLGSVKKLYDLANDVKRVPSGRITMTTMPWVSDPQDPDAHVIPKPGDSDKLFSLVRNDVALDGKDKKKDGKDQKTTAPASPKQNVPVTVFNGTGTLVEPPVTGRGSDIAAFLVKQGFAKATADSTPRVQADTTLSYPRAVQRADALAVATALGLPESAVRHSPEVQQITLVVGGDWRTGTTYAKAGEGGRAGEGGAAPAPAASASGKPGAENGKPADGKPKADDNKAPESADPLNGDDKSACMKVNPLNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD4</accession>
    <name>A0A2G1XJD4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2079 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15980</name>
        <name evidence="4" type="ORF">CYQ11_12095</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51249">
        <property type="protein sequence ID" value="PHQ51249"/>
        <property type="gene ID" value="BLA24_15980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13526">
        <property type="protein sequence ID" value="PPT13526"/>
        <property type="gene ID" value="CYQ11_12095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="483" mass="52287" checksum="204AAC8C42F0F01B" modified="2018-01-31" version="1">MDSATADVSAPGRSTAGAPRPGPSWPARLRSPRLDPYWLSGVLFLLYTTLSVCRHRRMLTMSWDLGIFEQAIRGYAQLQAPIADLKGPGTNILGDHFSPVTALVAPFYRAFPTPVTLLVVQAALFALSAIPVTRLAARLLGRGRGLALGAAYGLSWGVQRAVDFDFHEIAFAMPLLAFSLEAVVRGRWRAAFCWAVPLVLVKEDMGVTVAAIGVLMLVRLRRGGRDRRAVALAAGLVAFGLAAAVLALGVIIPGFNSGGSYDYWNKLSADQGPAPTIPFETAARTLLWTLLPTTGLLALRSPVLLVTLPTLGWRFASHEEHYWGTDWHYSAVLMPVVFVALADALATAYDSRRPWLRRYAAQLPAAVVAAACALSVSLPLYSLTMPDTYRIPPGVKAAERLLDRIPDGATVETDVGPISRLVNRCRVFWIGDTRGIDPDYVAQHRGDGRTDADLVAEAQRMHPGAEYAPVGNEGGYTVLKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL0</accession>
    <name>A0A2G1XJL0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13855</name>
        <name evidence="4" type="ORF">CYQ11_01550</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51413">
        <property type="protein sequence ID" value="PHQ51413"/>
        <property type="gene ID" value="BLA24_13855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11754">
        <property type="protein sequence ID" value="PPT11754"/>
        <property type="gene ID" value="CYQ11_01550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="148" mass="15431" checksum="5FA92933721B8AF0" modified="2018-01-31" version="1">MYADWAPQLTALIDACDGPFTPRTLTVLPVGLTWPPTAGVTLLGDAAHLMPPVGMGANMAMLDAAELALALAADRTDPFAAVRAYETAMFERAATAARASAAVMDIVISRDGARNTLDFFQSHDAGLPDRPGPSGGNPDAPLQERSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJX8</accession>
    <name>A0A2G1XJX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_13515</name>
        <name evidence="8" type="ORF">CYQ11_01235</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51545">
        <property type="protein sequence ID" value="PHQ51545"/>
        <property type="gene ID" value="BLA24_13515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16275">
        <property type="protein sequence ID" value="PPT16275"/>
        <property type="gene ID" value="CYQ11_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="39843" checksum="6A59F597FB468AC4" modified="2018-01-31" version="1">MLMAVACGLSVAGNYFAQPLLDVIGRDLHMSSAVSALVVTVAQVGYALGLILLVPLGDLLERRRLAVVLCAATAVFLAVTASAVNAAGLLIGTALTGLTSVAAQVVVPYAATLAAPEKRGRTVGTVMAGLLLGILLARTAAGLLSDLGGWRTAYWVNAALMAVMALLLRLALPRLRTRAGLTYPKLLGSTMALFAHEPVLRRKATLGALSFAAFSVLWTALTFLLSGPAYGWSESAIGMLGLLGAAGSLSASVAGRLVDRGLAHRVTGIAACLLLASWALLGLGGPGGALALTALLAGVVVLDAAVQGVHISSQNLVYALRPEARNRLNSAYMTSYFVGGAVGSALTSAVWNAAAWHGVCALGGTISAALVTVWLTEHRAAGRTSSQGTVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJZ9</accession>
    <name>A0A2G1XJZ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06295</name>
        <name evidence="4" type="ORF">BLA24_06310</name>
        <name evidence="2" type="ORF">BLA24_13410</name>
        <name evidence="5" type="ORF">CYQ11_01130</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000076">
        <property type="protein sequence ID" value="PHQ52644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000076">
        <property type="protein sequence ID" value="PHQ52647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51501">
        <property type="protein sequence ID" value="PHQ51501"/>
        <property type="gene ID" value="BLA24_13410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52644">
        <property type="protein sequence ID" value="PHQ52644"/>
        <property type="gene ID" value="BLA24_06295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52647">
        <property type="protein sequence ID" value="PHQ52647"/>
        <property type="gene ID" value="BLA24_06310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11683">
        <property type="protein sequence ID" value="PPT11683"/>
        <property type="gene ID" value="CYQ11_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="30400" checksum="3BA92A776300EB7F" modified="2018-01-31" version="1">MRTAGEHARLWTAAGSPQVELLAARFEHFTFDRHSHEQLSVGVIEQGAEGLHVAGGKVVIPAGHLVILNPGQVHTGFAAAESGWRYRMFYFDTAMVDELAHEHLGVRNTWFQETAVRDAGLFARLRRVHQEQENATDPLTAESLLLDGLGAVLRRHARTGRASATGAPRGAGRGPELARQLLHDRWTEPVTVAELSAAAGMPRSSLIAAFRRAYGLPPHAYLLRLRANRARRLLLAGQRPAEVAAATGFADQAHLTRVCKRYFGVTPGAIRPRGPSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKF1</accession>
    <name>A0A2G1XKF1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11430</name>
        <name evidence="2" type="ORF">CYQ11_02665</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51696">
        <property type="protein sequence ID" value="PHQ51696"/>
        <property type="gene ID" value="BLA24_11430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11945">
        <property type="protein sequence ID" value="PPT11945"/>
        <property type="gene ID" value="CYQ11_02665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="SSF49998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="290" mass="32741" checksum="2BAF3CC31FA0247F" modified="2018-01-31" version="1">MSESGRISWPPDQPVWTFDWRLADAPDEEGIVILGAAYRGHQVFAKASLPSLRVQYSGPCGPYKDPLNYNNSHPTSRCPGTRVCVYSYTSGGQRALSLESYHTIGAYRLTHRWVFWESGVVMPRLFSAGLQCPYDHRHHTYWRLDLDIDGAGRDLLLEYNTYTADEGWGQGWHPFRSEVRRVKNPASRRSWAVLDLDSGRGYHLLPGPNDGTADSFSSADLWLLRYRSGEDRYGRQGSAAADGLDAYLDDENTDGQDLVLWYCGHLFHRVGEGGDDWHSVGPDLIPFGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKF7</accession>
    <name>A0A2G1XKF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51629">
        <property type="protein sequence ID" value="PHQ51629"/>
        <property type="gene ID" value="BLA24_12840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="180" mass="20354" checksum="D1B94D0F89CE8A11" modified="2018-01-31" version="1">MHARPPSQRSGPLADVPGRALNELGLEDLRTLRRESRREEADLSYVRRLLQGRIDILRAELARRAAPAGPAVERLLVDRLSEILADGPPAHRSSARHVTLGTPHGEEYRRLAEDMLAEVRLSDTAARTDQELRDGMARLVAYERQVSVRRRGLQRMTDDCGAEMTRRYREGEARVDDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKI8</accession>
    <name>A0A2G1XKI8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11720</name>
        <name evidence="4" type="ORF">CYQ11_02960</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51748">
        <property type="protein sequence ID" value="PHQ51748"/>
        <property type="gene ID" value="BLA24_11720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11996">
        <property type="protein sequence ID" value="PPT11996"/>
        <property type="gene ID" value="CYQ11_02960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="224"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="856" mass="92171" checksum="B42914BA1CF5DD2F" modified="2018-01-31" version="1">MLAQGHLVADPLFVDAPDRIEDTASRFARSGQPAPPGWRRAERGGWVALRRRGVRLPAQGWKVHASATAEEAARVVDTVWEYCVERGVSFKFLRSRALLALVNSKRAPRSAGGKLVTIYPRGEEALERTLKELSSLLRGVKGPYILSDLRWDEGPLYLRYGGFSPRYCFARDGEYVPAVVRPDGEPVPDVRGPVFRVPPWARVPGFVDQRIRAARADGSGGLPFTVEKALHFSNGGGVYRATDRRTGRRVVLREARPYAGVDDNGMDAVARLTREHAVLERLRGLRCVPEVIARTRHWEHHFLVEEFVEGERLHEAIARRHPLFRPGAGEGEAAEYARWACAVLERIEAAVASLHGRGVVFGDLHPGNVLVRPDGGVCLVDFETAFEEGEGFTPVLGTAGFVAPWARSGRAVDAYALDCLRLAVFCPLTELTRFDPHKHEQLIRLVENRFPVPPGYGDRLRKGLAPPVAAPPPPAAGWPDGGPDGPGAGPCRWDAVLDSLGEAIRRSATPERADRLFPGDVRQFDGQGTALAFGAAGVLYALRRTGQDGGPCFEGYVDWLARAVERTRWPRPGLYDGLAGVAYVLDELGRPEVARETLGRLASFDLKGCGPGLFGGLAGIALVLLRFGDVEAAARLGGALATALDDDGPAPAGGVGLLRGWSGPALLFVRLFAATGESALLRHAERALARDVARCGVSGERYVGVRDGQRWLPTLGGGGAGVGVVLHEYLRHREDPRLARLRDRVRDSLGTELLLSSGLLDGHAGLLYALTHLGGRGAPVRTQLRGLGLHAVRFQGELAFPTEGLLRLSMDLGTGTAGVLLAVHAAVRRDSAASLPFLRPDGGRGDGAAVSGRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL63</accession>
    <name>A0A2G1XL63_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_10565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000124">
        <property type="protein sequence ID" value="PHQ51970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51970">
        <property type="protein sequence ID" value="PHQ51970"/>
        <property type="gene ID" value="BLA24_10565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="95" mass="9446" checksum="18576685C02C16D2" modified="2018-01-31" version="1">MTTSEQEVRVTPSQTVSSAARATSYDYDVIVVGSGFGGSVAALRLTEKGYRVGVLEAGGASPATACRRTPGTCATTCGHPPSVSTASSASTSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL69</accession>
    <name>A0A2G1XL69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000116">
        <property type="protein sequence ID" value="PHQ51988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51988">
        <property type="protein sequence ID" value="PHQ51988"/>
        <property type="gene ID" value="BLA24_10345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="83" mass="8786" checksum="9CA879ED81494C25" modified="2018-01-31" version="1" fragment="single">FFLTDVEVSVAGDTALVTCTENILSGGPAETEGELGPLVGQLVVATNVFRRSGDEWKVWSHHGSPVLAGREDEEDDDSAEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL95</accession>
    <name>A0A2G1XL95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_10920</name>
        <name evidence="2" type="ORF">CYQ11_00630</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51951">
        <property type="protein sequence ID" value="PHQ51951"/>
        <property type="gene ID" value="BLA24_10920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11605">
        <property type="protein sequence ID" value="PPT11605"/>
        <property type="gene ID" value="CYQ11_00630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="346" mass="38415" checksum="263C396D8A27971D" modified="2018-01-31" version="1">MSGNQNYINHVALVLDASSSMSHLSRKVIEVADQQIAYLARRSKELDQETRVTVYVFADKVECVIYDKDVLRMPSLKQLYRVGGMTALLAATLKSQRELAQTAQLYGDHSFLTFVLTDGQENASHHCPDVSTKNPRELVQAVAQLIATQEDNWTLAVLVPDQMGKREAMQCGFPKDNIAIWDATSTQGLEDAGHVIQQATENFMVGRAQGIRGSRAVFSTGAEAVNKDTIEAAGLTPVNPSEYQLIPVAREAAIREWVIECGHTYRTGCAFYQLSKSEKIQARKQIAVLEKKTDRVYTGPQARALLGLPDAEARVKPDHNDDFTIFVQSTSVNRKLVPHTRLLLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLB3</accession>
    <name>A0A2G1XLB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">D-beta-D-heptose 1-phosphate adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_10040</name>
        <name evidence="6" type="ORF">CYQ11_02510</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000105">
        <property type="protein sequence ID" value="PHQ52022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52022">
        <property type="protein sequence ID" value="PHQ52022"/>
        <property type="gene ID" value="BLA24_10040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11920">
        <property type="protein sequence ID" value="PPT11920"/>
        <property type="gene ID" value="CYQ11_02510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="173"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="329"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="478" mass="48631" checksum="B7C01D76648A5BC4" modified="2018-01-31" version="1">MSTGTPLLVVGDALLDRDLVGTAERLAPDAPVPVLDGCRELLRPGGAALAALLAARAGRSVTLVAPLGTDAASRQVRALLEPLVTLVTLPLDGPLPEKTRVMAGGRPVVRLDQGTGRAAGPCERALRAVAEAPAVLVADYARGAAEVLREVLAACAPHTALVWDPHPRGGPPVPGARLVTPTGEEARRFAGDGAADGDSLGAVARTAAELVRRWRAVSVAVTLGRRGALLCQGDGPLVVPAASQHSGDACGAGDCFAATAAGLLGDGALPAEAVQGAVAAATRYVAEGGARTATTGPSSTAVPGVPVPEADALHLARRVRAASGTVVAAGGCFDLLHAGHVSLLQQARGLGDCLIVCLNSDASVRRRKGEGRPFTPLRDRIRVLQALQCVDAVAVFEEDTPEGLLSRLRPHVWVKGGDYAVEQLPEAAQLASWGGQAVLLPYLDGRSSTLLATRAAAGLAAARRTTAPAGASPPVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLL0</accession>
    <name>A0A2G1XLL0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09560</name>
        <name evidence="6" type="ORF">CYQ11_28170</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52154">
        <property type="protein sequence ID" value="PHQ52154"/>
        <property type="gene ID" value="BLA24_09560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16235">
        <property type="protein sequence ID" value="PPT16235"/>
        <property type="gene ID" value="CYQ11_28170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="23684" checksum="AFEEC58E36FF8E89" modified="2018-01-31" version="1">MSIKLLIADDQAIVRSGLRLILEDQPDITVIAEAADGAEAVDLARRLRPDVCLVDIRMPRLDGIEVTRALAGPGVVNPLQVVIVTTFDLDEYVYGALRSGAVGFILKDAGPTLLIEAVRAASTGEALISPSITVRLLQHLAPVKPSKTATRPVKRLSEREIEVIKAIARGRTNQEIAAELFISLSTVKSHVASVQTKLGLRNRVEIAAWAWESQLIRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLN7</accession>
    <name>A0A2G1XLN7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09570</name>
        <name evidence="6" type="ORF">CYQ11_28180</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52155">
        <property type="protein sequence ID" value="PHQ52155"/>
        <property type="gene ID" value="BLA24_09570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16236">
        <property type="protein sequence ID" value="PPT16236"/>
        <property type="gene ID" value="CYQ11_28180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="299" mass="31540" checksum="A3BE7BCEF4E83329" modified="2018-01-31" version="1">MTPVLEAHGLGKRYGRRQALTDCHLNIPQGRVVGLVGPNGAGKSTLLQLACGLIAPTEGTISVLGARPAADAAHLAKVGFVAQDTPVYAGLSVAEHLRMGAKLNPSWDAPLAKRRIAQIGLDPRQKAGRLSGGQRAQLALTIAAAKRPELLIFDEPAAALDPLARHAFLENLMEFVADLGASAILSSHLLGDVERVCDYLIVLSESRVQVAGTVQDLLAAHYRFTGSRGDFTSLPPGVEAIETDNTLSGSAVIVRADGPLPPVGWNVEKIELEELVLAYMTRANSGSVRPASMASEAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLP0</accession>
    <name>A0A2G1XLP0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09360</name>
        <name evidence="4" type="ORF">CYQ11_27970</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52120">
        <property type="protein sequence ID" value="PHQ52120"/>
        <property type="gene ID" value="BLA24_09360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16200">
        <property type="protein sequence ID" value="PPT16200"/>
        <property type="gene ID" value="CYQ11_27970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="174"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="39606" checksum="2AE78F19E9D0B8F1" modified="2018-01-31" version="1">MTVAEGLKSAMRERVSAHREQLLTLSRRIHGHPETAFAEHRAAAWCAEALREHGFAVTAPAHGLETAFSATVGSGPVTVAIACEYDALPGLGHACGHNLIAAAGVGAALALAPYAAELGLTVRVLGTPAEERGAGKALLLDAGAFDGVDAAMMVHPCPFEVAEFRSFALGTLSVAYRGRSAHPSLNPHEGRNAADALTVAQVALGLLRQQLPPHWKVHGVTTSAGTAPNAIPDRATAEYEIRASAAEDLRELRERVEACFRAGALATGCEVTLTRPEPDYLDFRTDPELIALWRANARELGRPEPQQRDAFACTDMGNVSHVVPTIHPVLDITGGACGPHEPEFAEAAVSPAAERAVLDGAVGMAWTAADFASGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR8</accession>
    <name>A0A2G1XLR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08585</name>
        <name evidence="3" type="ORF">CYQ11_03840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52214">
        <property type="protein sequence ID" value="PHQ52214"/>
        <property type="gene ID" value="BLA24_08585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12147">
        <property type="protein sequence ID" value="PPT12147"/>
        <property type="gene ID" value="CYQ11_03840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="192" mass="20662" checksum="ED56C7F6AF9DD27B" modified="2018-01-31" version="1">MISRVNKHCTVELQALPPRIRQVRRIVSAQLRYWHLDPLIEPAALGVTELLTNVHQHAEPDKRCTVEIDLLLDRLTVSVRDHDPRMPVIGDTDVVSTHGRGLALVAAMSSSWGVQERHDGGKVVWFTLAVPSAAPATAPRLTRAVESAVAFDRPSLGLAARAEPALAAPALGFGPTALRGRSPARAYSAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM45</accession>
    <name>A0A2G1XM45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08400</name>
        <name evidence="2" type="ORF">BLA24_13660</name>
        <name evidence="4" type="ORF">CYQ11_01355</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000091">
        <property type="protein sequence ID" value="PHQ52293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51383">
        <property type="protein sequence ID" value="PHQ51383"/>
        <property type="gene ID" value="BLA24_13660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52293">
        <property type="protein sequence ID" value="PHQ52293"/>
        <property type="gene ID" value="BLA24_08400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11723">
        <property type="protein sequence ID" value="PPT11723"/>
        <property type="gene ID" value="CYQ11_01355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="230" mass="24396" checksum="71B4D0B82B837A4A" modified="2018-01-31" version="1">MSPLAETAALFADRTRAAFCLALLDGRAWTAGELARHAGVRPSTASEQLSRLVESGLLAEERQGRHRYVRLAGPDAAALIEALASYGSATPRPGSLRASGRLSAEARARTCYDHLAGRLGVTLADATIARGLVSTDGGLAVTPAGRAWLADALGFERPPGTRRPLVRSCLDWTERRPHLAGTLGAALCETALERRWVRRVGSGRAVKVTPEGAEAFRELLGAEVTPPARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMC9</accession>
    <name>A0A2G1XMC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08065</name>
        <name evidence="3" type="ORF">CYQ11_00510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52388">
        <property type="protein sequence ID" value="PHQ52388"/>
        <property type="gene ID" value="BLA24_08065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11591">
        <property type="protein sequence ID" value="PPT11591"/>
        <property type="gene ID" value="CYQ11_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="106" mass="12003" checksum="5DE91E0C36459035" modified="2018-01-31" version="1">MEDQNAHKNAAGKDRGDYKGMGLPAEKQPKSGQQCDEYPFRTTLEGAASKDWDFSLRAVDRSDNAGAGSRLKLYVLHERILRWDAGLADPQRSNDAYWVNVRYSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMK4</accession>
    <name>A0A2G1XMK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06790</name>
        <name evidence="3" type="ORF">CYQ11_26940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52482">
        <property type="protein sequence ID" value="PHQ52482"/>
        <property type="gene ID" value="BLA24_06790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16015">
        <property type="protein sequence ID" value="PPT16015"/>
        <property type="gene ID" value="CYQ11_26940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17458" checksum="9D0742D65367CC2C" modified="2018-01-31" version="1">MATGVDRSAGDAGSPLAQRLNYLFAAMHPPGAPYTNAHVAEEISRGEEYGGVTLTEQYLSMLRNGRRANPSPDVLRALAKFFAVPVGYLMGDLSASQAARVEEEVRFLVAMRDQRVRAIALRSVGLPPEVQDSLTTIISQFRQQMNLPSDPPDAGREERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN91</accession>
    <name>A0A2G1XN91_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05420</name>
        <name evidence="3" type="ORF">CYQ11_01880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52715">
        <property type="protein sequence ID" value="PHQ52715"/>
        <property type="gene ID" value="BLA24_05420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11809">
        <property type="protein sequence ID" value="PPT11809"/>
        <property type="gene ID" value="CYQ11_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="20984" checksum="543E10AC1F60FAD5" modified="2018-01-31" version="1">MKLLPPADVPAATRFGRARAAWRAAHEPVAGVSRRVRRVACAIPLTVLPSSLWRLPAAFDRGIGFGERAYVVFLSVLSEVLAFTAFGLVARWGEVFPRWIPFLGGRRVPARAAVVPAALGAGLLTGMWTVLTVATQIAGKTIRGDDLPGDFPSEAGGWEAASFYVCYAPLTLWGPLLAVLTVAYGKRRRAAGSAVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR6</accession>
    <name>A0A2G1XNR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04635</name>
        <name evidence="3" type="ORF">CYQ11_28895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52860">
        <property type="protein sequence ID" value="PHQ52860"/>
        <property type="gene ID" value="BLA24_04635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11481">
        <property type="protein sequence ID" value="PPT11481"/>
        <property type="gene ID" value="CYQ11_28895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304801" evidence="1">
        <location>
            <begin position="26"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="32689" checksum="E6832065368D2870" modified="2018-01-31" version="1">MLKAASAAAGLAAAGALAGAGTAGAAQRTAWRGAAVRPVERTGRQVAGFRDASGRVTVSVFSYHGSPAQQHWIDQTVRVGDGDMIAVGGGATAVEGPNGALLTASYPNDDLSGWTVSSKDHLDPQPHELVAYVIGLKIAGMTRDQLLRSVHVSRSDSGTAPHPEAEAGIPSSRDYALVGGGFKVNWYGAGNLATASFPATDYSWKARSKDHVVSDPASIRSFAISLRRDLPVGRVSSVIVHADSGQAQHPAAVATLPPGYALTGGGAEVHYRGAGNLLWRLEPSTTWTPAFTAASKDHHIADPATLTAYALGIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR8</accession>
    <name>A0A2G1XNR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05930</name>
        <name evidence="3" type="ORF">CYQ11_02405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52831">
        <property type="protein sequence ID" value="PHQ52831"/>
        <property type="gene ID" value="BLA24_05930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16306">
        <property type="protein sequence ID" value="PPT16306"/>
        <property type="gene ID" value="CYQ11_02405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="254" mass="28282" checksum="0B08CD86C250A511" modified="2018-01-31" version="1">MRAAAPVSLDEVNQRAALLARFDHSYLVPADVFLRLAGRLTDPGRPGGPFRALTIDGRRTFRYHSVYYDTPGLRSFHDHRQGRRLRFKIRERLYEDSGERQFEIKLKGRRGETVKHRRPLTGPGTPLDPCHQAFLAETLRHAYGIEPPAALHPSLSTDYLRATLVADGARITCDAGLTCEDLRAGPSVHCAGDLVLVETKTTGHLTEADRLLHAYGVRPAVFTKYCAALAALHPALPANRWHRAARRAFGAHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPB6</accession>
    <name>A0A2G1XPB6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_03930</name>
        <name evidence="9" type="ORF">BLA24_03945</name>
        <name evidence="7" type="ORF">BLA24_24290</name>
        <name evidence="10" type="ORF">CYQ11_21785</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000058">
        <property type="protein sequence ID" value="PHQ53060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000058">
        <property type="protein sequence ID" value="PHQ53061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49189">
        <property type="protein sequence ID" value="PHQ49189"/>
        <property type="gene ID" value="BLA24_24290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53060">
        <property type="protein sequence ID" value="PHQ53060"/>
        <property type="gene ID" value="BLA24_03930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53061">
        <property type="protein sequence ID" value="PHQ53061"/>
        <property type="gene ID" value="BLA24_03945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15161">
        <property type="protein sequence ID" value="PPT15161"/>
        <property type="gene ID" value="CYQ11_21785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="27262" checksum="873AC7169C99C9ED" modified="2018-01-31" version="1">MTMAVAAQVLRSEWTKIKSVRSTVWTLGLAVVVTVGLGALISALTANAFDGMPEKDKILFDPTYTSFAGMGLGQLALIVFGVLVVSNEYSTGMIRTSLAAVPQRGTFLACKIAIAALLAFAVAMVTSFVTFFVGQAMLDGHKAQLGDPGVLRAVVGGGLYMTLIAVFSMGVATMLRSPMLSLGILMPFFFLISNILGNVPATRKVGRYLPDQAGQKVMQVVTRDSDAPYGPWGGFAIMVLWVVAALAGGYALLKKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPH5</accession>
    <name>A0A2G1XPH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Allophanate hydrolase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02030</name>
        <name evidence="6" type="ORF">CYQ11_04390</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53147">
        <property type="protein sequence ID" value="PHQ53147"/>
        <property type="gene ID" value="BLA24_02030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12237">
        <property type="protein sequence ID" value="PPT12237"/>
        <property type="gene ID" value="CYQ11_04390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="9"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="212" mass="22296" checksum="B79C9C8D13E7E9D7" modified="2018-01-31" version="1">MTTPGPGRPRALPVGRDALLLEVGGPEEAQALHAELLRRRTAGDLPPVREIVPAARTVLLDGVADPRALAADLTRRAVPPLTTEGSAPVVLPVHYDGPDLAEVAALWGVAEDAVARIHSGCEFRVAFCGFSPGFGYLTGLPERLHVPRRATPRTAVPAGSLALAGPYTGVYPSASPGGWQLIGRTDTVLWDPDREPAALLSPGTRVRFEACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPM1</accession>
    <name>A0A2G1XPM1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation-transporting P-type ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_02245</name>
        <name evidence="11" type="ORF">CYQ11_04605</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53182">
        <property type="protein sequence ID" value="PHQ53182"/>
        <property type="gene ID" value="BLA24_02245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12274">
        <property type="protein sequence ID" value="PPT12274"/>
        <property type="gene ID" value="CYQ11_04605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="769" mass="77180" checksum="32907C37D964FCD0" modified="2018-01-31" version="1">MSTTTTGTTGTTDSAVVTELIVGGMTCAACVARIEKKLGRLEGVSAGVNLATGRARVTHPAAVTAEELMAVVVAAGFTAALPAPEPAKGAEEPAAPAGTAPATDRLLITALLAVPVLVLSMVPALQFRNWQWLCFALASPVAVWGSWPFHERALRGLRHSTATMDTLVSLGVLASYAWSAYALFLGGAGEPGMQMPFTLVPSATGGTADVYLEAVVGVPLFVLTGRLLEARARHGTGSALRALASLAAKEVAVRAADGTERRIPVEDLRVGDHFVVRPGEKVATDGVVVAGASALDLSLVTGESAPVEAGPGTAVIGGAVNSGGLLEVRAEAVGADTQLARIARLVEEAQAGKARVQRLADAVAGVFVPAVLAVAVTVLGFWLGAGASPQAAVTAAVAVLVVACPCALGLATPTALLAATGRGAGLGILVGGPQALEGLRRVDTVVLDKTGTLTTGSMTVTEVTARAGGLGRDAALRLAAAAEAGSEHPVGRAIHAHAVEAAGPEAKALPAAAGFTATAGVGVRAEVAGRLVEVGRPRPGGEHGAPAGDLADALHRAERAGHTAVVVHVDGTPEAVVALGDTVRAGSYRAVDHLKRLGLRPVLATGDSEAAARAVAGELGIAEVHARATPEDKAALVRTLRERGHRVAVIGDGVNDTAALAGADLGIAMGSGTDAAIGAADVTLVREDMSALADAVRLARRTSVTVRSNLAWAFGYNLVTVPLAAVGLLNPMVAAAAMSASSLLVVGNSLRLRGWQPRPAGSRNSRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPY4</accession>
    <name>A0A2G1XPY4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_03105</name>
        <name evidence="8" type="ORF">CYQ11_05405</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53307">
        <property type="protein sequence ID" value="PHQ53307"/>
        <property type="gene ID" value="BLA24_03105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12404">
        <property type="protein sequence ID" value="PPT12404"/>
        <property type="gene ID" value="CYQ11_05405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="14"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="256" mass="26761" checksum="B8549E281A996314" modified="2018-01-31" version="1">MTWTEMQPLLRDACLDTLFMVWWSTVYAVVGGLPLGLLIVLTDRGALLQNAVVNKVLGAVLNLGRSLPFIILIVWLIPFSRFVVGTSIGPSAAVVALAVGAVPFFARLVETAVREVDHGLVEAVQSMGGGTWTIVFKVLLPQALPSLIAALTTTVITLIGYSAMAGAVGGGGLGNLAITYGYMRSERDLMNITIVLLIVIVTVVQLAGDLAVRRLAARGGRSASPVGLRRLLPAQRKPADAAAPAATEAVAPDKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQE2</accession>
    <name>A0A2G1XQE2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00465</name>
        <name evidence="2" type="ORF">CYQ11_07475</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53442">
        <property type="protein sequence ID" value="PHQ53442"/>
        <property type="gene ID" value="BLA24_00465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12747">
        <property type="protein sequence ID" value="PPT12747"/>
        <property type="gene ID" value="CYQ11_07475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="8328" checksum="6BDD28D608CE79A4" modified="2018-01-31" version="1">MNAAPEAGTWVVDVRRDRVGEVVEVSDGRVSLRDLTSREEWEASPCDVRPATANDELRAKVADLNHRSVRRQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQH6</accession>
    <name>A0A2G1XQH6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_00770</name>
        <name evidence="7" type="ORF">CYQ11_07780</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53497">
        <property type="protein sequence ID" value="PHQ53497"/>
        <property type="gene ID" value="BLA24_00770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12802">
        <property type="protein sequence ID" value="PPT12802"/>
        <property type="gene ID" value="CYQ11_07780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="84"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="295"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="640" mass="68218" checksum="5AAE41EE8C26B5EA" modified="2018-01-31" version="1">MTAPRQPRRPVPGPARPAARPARPRPGSQALRLGNPRPRLRMIGVGLTLVLLVFTVRLLQVQAVDAGAYAAQANVNRYIPVTLAAERGAITDRTGVDLATTVDAYDITAAPDLLTPERAKAEGAARLAAELLAPVLDEQADVLEQRLTANPKSKYVVLARRQTPQVWKKITELKKQQQEKANRTKGVNVLAGVNRESHSKRVYPNGDLAAGLLGFVSGDGQGGGGLEAQLEETLAGKNGKRVYAQSGGRQVPTGDVKEQAAVPGSDVELTLDRDIQWAAQNAISRQVTDSAADRGYVVVQDTRTGEILAMANAPGYNPNDLAHADRAAMGNFALQDAYEPGSVSKVMTMAAVLEEGVANPATHVEVPNRLPRADRAFADDIDHPTWHLTLNGVLAKSSNIGTILASEQLGKTREEANKVLYTYLRRFGVGRPTGLGFPGETPGILAKPGEWTASRPYTIPFGQGLSLNAVQAASVFSTIAGGGERVQPTLVRGTKGPDHRFTAAPPPPRTRVVSEKTARQLSEMLESVVDDQEGTGTKAKIPGYRVAGKTGTSNRVDPQTGRYHGYTASFAGFAPADQPRITVYCAIQNPTRGSYFGGQICGPVFKQVMEFALKTLQVPPSGSQPPRLPVSYDGRPAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ5</accession>
    <name>A0A2G1XQJ5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ORF">BLA24_00740</name>
        <name evidence="14" type="ORF">CYQ11_07750</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53492">
        <property type="protein sequence ID" value="PHQ53492"/>
        <property type="gene ID" value="BLA24_00740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12797">
        <property type="protein sequence ID" value="PPT12797"/>
        <property type="gene ID" value="CYQ11_07750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="188"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="364" mass="38506" checksum="48F4021D6804578B" modified="2018-01-31" version="1">MHVVLAGGGTAGHIEPALALADALRRQDPTVGITALGTERGLETRLVPERGYELGLIPAVPLPRKPTPELITVPGRLRGTIKAAEQILERTQADCVVGFGGYVALPGYLAAKRLGVPIIVHEANARPGLANKIGSRYAASVAVSTPDSKLRNARYVGIPLRRTIATLDRAAMRPQARAAFGLDPNLPTLLVSGGSQGARRLNEVVQAVAPLLQRSGVQILHAVGPKNELPHADNMPGMPPYIPVSYVDRMDLAYAAADMMLCRAGAMTVAELSAVGLPAAYVPLPIGNGEQRLNAQPLVKAGGGLLVDDAELTPEWVQSQVLPVLSNPHRLYEMSRAAAEFGRRDADELLVGMVYEAIAARRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQK7</accession>
    <name>A0A2G1XQK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00935</name>
        <name evidence="6" type="ORF">CYQ11_07945</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53527">
        <property type="protein sequence ID" value="PHQ53527"/>
        <property type="gene ID" value="BLA24_00935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12832">
        <property type="protein sequence ID" value="PPT12832"/>
        <property type="gene ID" value="CYQ11_07945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="4">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="264" mass="28785" checksum="64AE33121B86AF91" modified="2018-01-31" version="1">MPLLPGAEPFRHDGGEVGVLVCHGFTGSPQSVRPWADYLAERGLTVSLPLLPGHGTRWQDMAVTGWQDWYAEVDRELWTLRERCSRVFVCGLSMGGALSLRLAARHGDAVSGAVLVNPANKVHGLAARALPVVRHLVRTTKGIASDIAKPGMEETGYDRVPLHAAHSFRRFLRMLDSELPQVTQPLLLMHSPHDHVVPPADSARILARVSSRDVTERLLDRSYHVATLDHDAPTVFEETYAFIGRLSAGTGEESAGAPRTASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQN3</accession>
    <name>A0A2G1XQN3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BLA24_01040</name>
        <name evidence="19" type="ORF">CYQ11_08050</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53546">
        <property type="protein sequence ID" value="PHQ53546"/>
        <property type="gene ID" value="BLA24_01040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12851">
        <property type="protein sequence ID" value="PPT12851"/>
        <property type="gene ID" value="CYQ11_08050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="17">
        <location>
            <begin position="239"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PHQ53546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PPT12851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="351" mass="38415" checksum="878DEF889230ED52" modified="2018-01-31" version="1">MSSQDIPEETLPSKQGDAHEGVVATAGDPFADPGLPPHEPRIQDIDEQAAKRSERVVAFLFMLSMLATIGFIAAYVTLPIDKSIYVFPIGHISALNFSLGLTLGVALFCIGAGAVHWARTLMSDVEHADERHPIQAEPEVKAKVMADFKQGAEESTFGRRKLLRNTMFGALALVPLSGVVLLRDLGPLPGTKLRKTAWSAGKMLINQNTMQPLRPEDIQVGSLTFAMPEGMTEEDHDFQQEIAKAALMIVRLRPENIKDKRELDWSADGIVAFSKICTHVGCPISLYEQQTHHVLCPCHQSTFDLSDGGRVIFGPAGHALPQLRIKVNDKGYLEAMGDFAEPVGPAFWERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQS5</accession>
    <name>A0A2G1XQS5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000002">
        <property type="protein sequence ID" value="PHQ53594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53594">
        <property type="protein sequence ID" value="PHQ53594"/>
        <property type="gene ID" value="BLA24_00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="304" mass="33493" checksum="AB323403F6210651" modified="2018-01-31" version="1">MARSARLPARSRIRRRRVTSTAWRPSPGAGRQPSRPCHRAYPPRAVGGCRRGGKPDSGAGTGEPNQRHHQQRHAGTQGPQPLTARPLRKRAPRADRDVHPYPPQVAAPLKENLRAVPLRLAGDAVVLRDFTMDDVDDALKIVGDDRVTTWLSFDSRDRQGTQEMLEGAISRAQREPRDEYYLAIVAPPSDHVIGFCRIGLSGVRAGKLGYAVAASEWGKGYATDAARTMIDFGFRTLGLHRISAAIGPDNLASINLIERLGFTREGVLRDHVHTNGVWRDSILFSTLAKEWPESQSEGPKTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9A4</accession>
    <name>A0A2G1X9A4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ORF">BLA24_30320</name>
        <name evidence="14" type="ORF">CYQ11_23415</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47810">
        <property type="protein sequence ID" value="PHQ47810"/>
        <property type="gene ID" value="BLA24_30320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15435">
        <property type="protein sequence ID" value="PPT15435"/>
        <property type="gene ID" value="CYQ11_23415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="146"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="379"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ47810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="497" mass="54373" checksum="064DCBE40CD5FDD0" modified="2018-01-31" version="1">MSAKTYEVRTYGCQMNVHDSERLSGLLEDAGYVRAPEGTAEGEADVVVFNTCAVRENADNKLYGNLGRLAPMKTKRPGMQIAVGGCLAQKDRDTIVKRAPWVDVVFGTHNIGKLPVLLERARVQEEAQVEIAESLEAFPSTLPTRRESAYAAWVSISVGCNNTCTFCIVPALRGKEKDRRTGDILAEIEALVGEGVSEITLLGQNVNAYGSDIGDREAFSKLLRACGKIEGLERVRFTSPHPRDFTDDVIAAMAETPNVMHQLHMPLQSGSDTVLKAMRRSYRQERFLGIIEKVRAAMPDAAISTDIIVGFPGETEEDFEQTMHVVREARFANAFTFQYSKRPGTPAATMEGQIPKEVVQARYERLVALQEEISWDENKKQVGRTLEVMVAEGEGRKDDATHRLSGRAPDNRLVHFTKPDEPVRPGDVVTVEITYAAPHHLLAEGPAKAVRRTRAGDAWERRNAAPAEKPAGVMLGIPTIGAPVPTPAPAATGCGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9C2</accession>
    <name>A0A2G1X9C2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdR</name>
        <name evidence="11" type="ORF">BLA24_30405</name>
        <name evidence="12" type="ORF">CYQ11_23500</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47827">
        <property type="protein sequence ID" value="PHQ47827"/>
        <property type="gene ID" value="BLA24_30405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15452">
        <property type="protein sequence ID" value="PPT15452"/>
        <property type="gene ID" value="CYQ11_23500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="10">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ47827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="178" mass="19336" checksum="12E39D5648BD88A0" modified="2018-01-31" version="1">MHCPFCRHPDSRVVDSRTTDDGCSIRRRRQCPDCSRRFTTVETASLMVIKRSGVTEPFSRNKVISGVRKACQGRPVTEDALALLGQRVEEAVRATGSAELSTHDVGLAILGPLKDLDLVAYLRFASVYQAFDSLEDFEAAVAELRAGLRRAEREAAPTTDADGSDEDSQVPAPAVAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9D7</accession>
    <name>A0A2G1X9D7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30470</name>
        <name evidence="4" type="ORF">CYQ11_23565</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47840">
        <property type="protein sequence ID" value="PHQ47840"/>
        <property type="gene ID" value="BLA24_30470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15465">
        <property type="protein sequence ID" value="PPT15465"/>
        <property type="gene ID" value="CYQ11_23565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="27305" checksum="6170A8471D557E8F" modified="2018-01-31" version="1">MPYDPSAFPPFAVTVDLVVLTVRQHALCALAVRRGEPPYQGRWALPGGFVRGDEDLATAAARELVEETGLHAADPAGPVPPNAAHLEQLATYGDPRRDPRMRVVSVAHLALAPDLPAPRPGGDARSVRWAPVEDLLDQEVGYGRDGEQVTPLAFDHARILADGVERARSKIEYSSLATAFCPQEFTVGELRRVYEAVWGVVLDPRNFHRKVTGTPGFLVPTGGTTTRQGGRPAQLFRAGGATLLNPPMLRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9J6</accession>
    <name>A0A2G1X9J6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30765</name>
        <name evidence="2" type="ORF">CYQ11_23860</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47891">
        <property type="protein sequence ID" value="PHQ47891"/>
        <property type="gene ID" value="BLA24_30765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15516">
        <property type="protein sequence ID" value="PPT15516"/>
        <property type="gene ID" value="CYQ11_23860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="12836" checksum="D733A2F889C7461C" modified="2018-01-31" version="1">MTPPASRRDKGLVRPYVVTEGRSHPTRNTFDLVTLVMAHGDRPLGGLSPEKRALMELCLGGALSVAEIAGHLMLPVSVTKVLLGDLVDSGHLTTRAPIPSAQLPEAQILQEVLDGLRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9K9</accession>
    <name>A0A2G1X9K9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30895</name>
        <name evidence="2" type="ORF">CYQ11_23995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47912">
        <property type="protein sequence ID" value="PHQ47912"/>
        <property type="gene ID" value="BLA24_30895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15537">
        <property type="protein sequence ID" value="PPT15537"/>
        <property type="gene ID" value="CYQ11_23995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="90" mass="9882" checksum="C11D8EB81932CCB2" modified="2018-01-31" version="1">MGHDRRRNAAVRTAAVALAARLAELTGIAPRITDEPHAVRIEADVTDAALRRWTELLAVLERGTDYGVTNAPSGQVAWMRIESPRRGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9R4</accession>
    <name>A0A2G1X9R4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31375</name>
        <name evidence="2" type="ORF">CYQ11_24415</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47966">
        <property type="protein sequence ID" value="PHQ47966"/>
        <property type="gene ID" value="BLA24_31375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15590">
        <property type="protein sequence ID" value="PPT15590"/>
        <property type="gene ID" value="CYQ11_24415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="90" mass="9238" checksum="F67B0948153B608A" modified="2018-01-31" version="1">MGSAVTFGELGRLRGEELPPRIALSSVLLPAGTDQPVYPTLVRTEHGTTVAYACQYRQNPGSPGLLVALGLAPSAPGYTTTCVPAAISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9X5</accession>
    <name>A0A2G1X9X5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_31745</name>
        <name evidence="6" type="ORF">CYQ11_24800</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48028">
        <property type="protein sequence ID" value="PHQ48028"/>
        <property type="gene ID" value="BLA24_31745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15654">
        <property type="protein sequence ID" value="PPT15654"/>
        <property type="gene ID" value="CYQ11_24800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="29479" checksum="674C02218C6CA147" modified="2018-01-31" version="1">MTPALTTENSTEPVVDETQAAVRIDRVHKGFGRSGGGQPVLEDISLDVRPGEFVCILGASGCGKSTLLNLVAGLDRPTSGTIDVPGGRPALMFQEHALFPWLTAGRNIELALRLRGVPRTERRTEAERLLDLVRLGGSHGKRVHELSGGMRQRVALARALAQDSRVLLMDEPFAALDAITRDVLHHELTRVWSQTRLSVLFVTHNVREAVRLGQRVVLLSSRPGKIVREWTVDIPQPRRIEDTAVADLSIEITEELRKEIRRHGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA00</accession>
    <name>A0A2G1XA00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NHLP family bacteriocin export ABC transporter peptidase/permease/ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_31950</name>
        <name evidence="13" type="ORF">CYQ11_25005</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48064">
        <property type="protein sequence ID" value="PHQ48064"/>
        <property type="gene ID" value="BLA24_31950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15690">
        <property type="protein sequence ID" value="PPT15690"/>
        <property type="gene ID" value="CYQ11_25005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022514">
        <property type="entry name" value="NHPM_micro_ABC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03796">
        <property type="entry name" value="NHLM_micro_ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="11">
        <location>
            <begin position="46"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="200"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="517"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="551"/>
            <end position="558"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="751" mass="80842" checksum="1E2F27374AE5A278" modified="2018-01-31" version="1">MTAPQPPAPAGRRRHRPEPKGGARRRSTPPTRGRTPRTVRTPSVLQMEAVECGAAALAMVLGHYGRFVPLEELRIACGVSRDGSRASNLLKAARGYGLTAKGMQMDLAALAGVRPPAVLFWEFNHYVVYDGMGRRFGRRGVYVNDPAKGRRFVTMEDFDTSFTGVVLTFEPGEDFRRTGRRPGVMGAMPARLRGTSGTMLAAVLSSLLLVAVGAAVPALSRTYIDMFLIGGRTSLLGVLFASMATALVLTATLTALQQANLLRGRIISSTLGSARFLRHLLRLPVTFFSQRNPADLVQRLQSNDAVAETLARDLAAAGVDAVVVVLYAVLLWTYDPQLTVVGIGIALLNVFAMRIVIHVRATGTQKLRAESARLTNTSYSGLTLIETMKATGGENGFFRRWAGQHAVTLDVQQRLGVPSAWLAVVAPTLAALNSALILMIGGLRAVEGHLSVGLLVAFQALVASFTAPITRLNGVAGRIQDFAADVARLKDVENFPVDPLYARREPAAGTRRLTGHVELENITFGYSPLDAPLLKDFSLSVGPGQQVALVGGSGSGKSTVSRLISGLYAPWEGTIRIDGMRLEDIPRGALAASVSFVDQDVFLFEGTVRDNIALWDPSVPDEAVVAALEDAAVYDVVARRPGGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSVMVLDEVTSALDAATEQVVIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDRGTVVERGRHEHLLAVPGAYAELVKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA18</accession>
    <name>A0A2G1XA18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31945</name>
        <name evidence="3" type="ORF">CYQ11_25000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48063">
        <property type="protein sequence ID" value="PHQ48063"/>
        <property type="gene ID" value="BLA24_31945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15689">
        <property type="protein sequence ID" value="PPT15689"/>
        <property type="gene ID" value="CYQ11_25000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="27988" checksum="8E15696AD89FD103" modified="2018-01-31" version="1">MQFRQKALSKLQSPEELDLPLRFARPQGRLVLAVTVLVMAAAGFWAFTGSVSSKLTAPGILIHAEGGYLLQSPYAGQVTAVFAKEGQLLPPGAPLLQVSTDRGDRAVRVVAGGRVTTLAARTGSVLTTGADVATVERVKNPGDPLVAMLYVPAGNSGAIPVGAPVDLDVQSVARERSGVLRGRVKAVGRAPQTQAQISGFLGDSRLAARFAGQKDPVAVLVELETSATTRSGYRWSSADGPPYALDSTTPVTAAVRLSAQHPVDWLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA78</accession>
    <name>A0A2G1XA78_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31985</name>
        <name evidence="3" type="ORF">CYQ11_25040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48069">
        <property type="protein sequence ID" value="PHQ48069"/>
        <property type="gene ID" value="BLA24_31985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15695">
        <property type="protein sequence ID" value="PPT15695"/>
        <property type="gene ID" value="CYQ11_25040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046210">
        <property type="entry name" value="DUF6243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19756">
        <property type="entry name" value="DUF6243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7745" checksum="24C4326BA826F267" modified="2018-01-31" version="1">MTDSKNINNPVGQGGGQRKKLSRAERQNNGPHRNRDRQSAAAQKAELVRKMREKARAAETAGQASDDTAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAA8</accession>
    <name>A0A2G1XAA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32445</name>
        <name evidence="3" type="ORF">CYQ11_25495</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48141">
        <property type="protein sequence ID" value="PHQ48141"/>
        <property type="gene ID" value="BLA24_32445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15767">
        <property type="protein sequence ID" value="PPT15767"/>
        <property type="gene ID" value="CYQ11_25495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="86"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="44470" checksum="09DDA576ABE8FF2B" modified="2018-01-31" version="1">MARTVRPEPPAPLRCRPTRRRVPVTIGAVFVDNVLLALRAARLFDGESLRTGPVMILTDNGRIVDVDFTGAHPPEGWAFTDLGDVTVMPGLVDAHSHLVFDPDGHAERQMVHDDDETVLARMRGHAARALRAGVTTVRDLGDRGYLALRLRDEFAAGVMGPHIVASGPPLTLTRGHCWYLGGEADDAEQAVAAVAARARRGADLVKVMATGGMSTTGSDPGGSQYDLAALRAVTEAAHRLGLPVTAHAHGAAGIADAVAAGVDGVEHCTFITASGVRPDPATVDAMAAAGTFVGATVVRPREGMPAEVLRTIEPYWRNQEAMHRRGVRVVCCTDAGINPHKPHDVLPGDLAYFASQVAPNVEALASVTSLAALSCGLGDRKGRIAPGRDADLLVIPGNPVHDIAAVREVRAVYRAGRPVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF9</accession>
    <name>A0A2G1XAF9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amine oxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32855</name>
        <name evidence="5" type="ORF">CYQ11_25905</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48210">
        <property type="protein sequence ID" value="PHQ48210"/>
        <property type="gene ID" value="BLA24_32855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15837">
        <property type="protein sequence ID" value="PPT15837"/>
        <property type="gene ID" value="CYQ11_25905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="507" mass="55953" checksum="DF8D15277E84F85F" modified="2018-01-31" version="1">MSDASASWHVHTFENLERRGRRVLVIGAGVSGLVAAYELERRGFDVEVLEGNTRIGGRIHTHRFGQRPGGPTVELGAMRIPSHHAHTLEYIRRMGLDGKLRAFSTLLSEENAFLHTDRGFVRIRDAARTLGRDFRHELERHRPGHHHDDATVAFGAWLTAIVDAIAPPDLREALRGDLSGRLLDMVARVDLTGHLRGPARDRVDLHSLFAAHPELRAGCSARLNSFLDDILTETSPDLLRLHGGMDQLTDRLAGRIRGPVTCGRRVTGLDVQGDHVVAHVRAGSRTTVRRADFVVCTVPFPAMRRMRLNGFDRDKRAVLRDVVYCPATKVAVLCRTPFWRESGIQGGASFTGGRIRQTYYPAPDGEPGRGAALLASYTIGDEAARLGRMSARRRHRLVLDELSVVHPELLSPGMVLDVVSMAWGHHPWTGGCTTRWGKNAAECEEERLRAARPVGRLFFAGEHCSKAPAWIEGAIESALEAVQAIERFEPGRRTTEATGRPNPAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAM2</accession>
    <name>A0A2G1XAM2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_33240</name>
        <name evidence="2" type="ORF">CYQ11_26290</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48273">
        <property type="protein sequence ID" value="PHQ48273"/>
        <property type="gene ID" value="BLA24_33240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15903">
        <property type="protein sequence ID" value="PPT15903"/>
        <property type="gene ID" value="CYQ11_26290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006521">
        <property type="entry name" value="Tail_protein_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09684">
        <property type="entry name" value="Tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="20244" checksum="CE772A38C09A7ACF" modified="2018-01-31" version="1">MSAYAARPLPLPAVYGHDTVALAFAAALGEAMAPAEERIDGLDAVLDPWRAPPAFLDWLIRITGARVEPGWPEGLRRKAVDLAPRLAAHRGTPYGLLLEAREIHGWVPPRFALVVDDPGRVFTHDDPAPRAGRMLTVTLTAPAGEDQRALESRLTRLVRAHCPAHLPFKVTVTLAHKAPDERSQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAY5</accession>
    <name>A0A2G1XAY5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32465</name>
        <name evidence="4" type="ORF">CYQ11_25515</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48372">
        <property type="protein sequence ID" value="PHQ48372"/>
        <property type="gene ID" value="BLA24_32465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16798">
        <property type="protein sequence ID" value="PPT16798"/>
        <property type="gene ID" value="CYQ11_25515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="424" mass="44928" checksum="45F2A019BD7D4A68" modified="2018-01-31" version="1">MPDWLALYYREPVELTHGEGRHVWDAEGRRYLDFFGGVLTTMTAHALPEVTKAVAGQAERILHTSTLYLDRHMVELAERIAALSGIPDARVFFTTSGTEANDAALLLATSHRRSNQILAMRNSYHGRSFSAIGVTGNASWSPTSLSPLQTLYVHGGVRSRGPYAHLSDGEFIVACVADLEDVLGQTHGGVAALIAEPVQGVGGFTAPPDGLYAAFREVLDRHGILWISDEVQTGWGRTGDHFWGWQAHAASGPPDLLTFAKGIGNGMSIGGVVARADVMNCLDANSISTFGGSPVTMAAGLANLTYLLEHDLQGNARRVGGLLIERLRAIAAGLPVVREVRGRGLMIGVELVGPDGAPSPDAASLALEHAREQGLLVGKGGREGNVLRLAPPMTLTVAEAEEGASMLEAALRRVQDATGGEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAZ2</accession>
    <name>A0A2G1XAZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene synthase HpnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hpnC</name>
        <name evidence="1" type="ORF">BLA24_33045</name>
        <name evidence="2" type="ORF">CYQ11_26095</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48386">
        <property type="protein sequence ID" value="PHQ48386"/>
        <property type="gene ID" value="BLA24_33045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16811">
        <property type="protein sequence ID" value="PPT16811"/>
        <property type="gene ID" value="CYQ11_26095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480:SF17">
        <property type="entry name" value="PTHR31480:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03464">
        <property type="entry name" value="HpnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="288" mass="31530" checksum="E0512F664A912EFC" modified="2018-01-31" version="1">MLDKAAHENFPVAPFFVPRAWRDDLMAVYGYARLVDDIGDGDLPPGGRDAELLGLDREQSDDRVAMLDAFEADLLRVFDRTGTGPRHPLLLRLRPTVRRCGLTPEPFLGLIGANRQDQRVRRYGTYADLLAYCELSANPVGRLVLGITGTATPERTRRSDAVCTALQIVEHLQDVAEDLRRDRVYLPAEDMERFRVTEADLARATGSASVRALVAYEAERARHLLNEGTPLVGSVHGRLKLLLAGFVGGGRAALRAVAAAGHDVLPGPPKPTKLSLLREVGATLRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB32</accession>
    <name>A0A2G1XB32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_29000</name>
        <name evidence="7" type="ORF">CYQ11_06475</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48422">
        <property type="protein sequence ID" value="PHQ48422"/>
        <property type="gene ID" value="BLA24_29000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12582">
        <property type="protein sequence ID" value="PPT12582"/>
        <property type="gene ID" value="CYQ11_06475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="198"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="376" mass="39226" checksum="1783866ACD72F610" modified="2018-01-31" version="1">MSSTPGPSHGRPPLHAVQVVGGGRGGSGAHVRSLTGGLVARGLRVTVCGPQEAADRYELTAGGAAFIPLRPGTSALAVAAIRAASRTADVVHAHGLRSGALAALALRGRPTPLVVTWHTRVRAEGARTHVVRLMERQAARAAAVVLGASSDLVAEARLRGARDARLAPVALPAPRVRPDDDDECLRLKARAELGAVARPLLVTVGRLEPGQGHGPLLDAARVWRRLDPEPLLVMAGEGGERAALQRRITDEELPVLLVGRRDDVPELLAAADVVILPSRWEARALLAQEALHAGVPLVATAVGGVPELVGDAAELVPYGDAGALAGAVAALLDDPLRCAELVAEGFRQAAQWPSEDDTVAHVLSVYDELRQRQDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBI3</accession>
    <name>A0A2G1XBI3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">BLA24_29890</name>
        <name evidence="20" type="ORF">CYQ11_05580</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48561">
        <property type="protein sequence ID" value="PHQ48561"/>
        <property type="gene ID" value="BLA24_29890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12437">
        <property type="protein sequence ID" value="PPT12437"/>
        <property type="gene ID" value="CYQ11_05580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="413"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="741"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PHQ48561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PPT12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="836" mass="89252" checksum="AC679240EB824891" modified="2018-01-31" version="1">MRAPLSWLREYVDLPAGETGRDVQAKLVAAGLEVERVERLGSDLTGPLVVGKVLTIEELEGFRKPIRFCTVDVGQANGTGEPQEIVCGARNFVVGDKVVVALPGAVLPGDFAIAERKTYGRMSRGMICSGDELGMGDDGTHGIIVLPPEHEVGTDAVALLELVDDVLDIAVTPDRGYCLSMRGIAREAATAYGLPLRDPALLDVPAPNGYGYPVQVADPTGCDRFTARTVTGLDPEARSPIWLQRRLQKAGMRPVSLTVDVTNYVMLELGQPLHAYDRARLDGAIGVRRARAGEKLTTLDGTKRVLDAEDLVITDERGPIGLAGVMGGAETEIAGPADGQGSTEVVIEAAHFDPVAIARAARRHKLSSEASKRFERGVDPQAASAAAQRTVDLLVLLAGGTAEAGVTEIVAPSGPRTISLHANHPDRVAGVEYGRETVVRRLQEVGCDVYGQDELIVTVPSWRPDLTDPNDLAEEVIRLEGYENLPSTLPQPPAGRGLTRRQRLHRRVGRALAGSGYVEALNYPFLGDWALDHLGLEADDPRRATVTLVNPLSDAEPALRTTLLPGLFAALRRNDGRGEHDLALFETGLVFRRSGDEPTPVRLPVDRRPTDEEIAALDAALPQQPRHAAVVLAGAREQAGWWGKGRPSTWADAVEAGRVVAREAGVELIVRQDQQAPFHPGRCAALLAVVDGEEVLVGNAGELHPRVTKAFGLPERTCAMEIILDRLERAGTPVVEAPHVSAFPVATQDVALVVDASVAAVDVEAALRDGAGELLESLRLFDVFTGTQLGEGKKSLAYALRFRADDRTLTAEEASAARDAAVAKAVERTGAVLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBP1</accession>
    <name>A0A2G1XBP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein terZ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28285</name>
        <name evidence="3" type="ORF">CYQ11_07185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48621">
        <property type="protein sequence ID" value="PHQ48621"/>
        <property type="gene ID" value="BLA24_28285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12699">
        <property type="protein sequence ID" value="PPT12699"/>
        <property type="gene ID" value="CYQ11_07185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="192" mass="20493" checksum="A6A19D8EC2C76769" modified="2018-01-31" version="1">MTVNLSKGQGISLQKADGATLTAVRMGLGWQAAPRRGLFGSRTREIDLDASAVLFADKQPVDVAFFQQLVSKDGSVRHTGDNLVGGAGQGGDDESILVDLQRVPVHVNQIVFTVNSFTGQTFAEVQNAFCRLVDETTGQELARYTLDGGGPYTAQIMAKVHRVGAGWQMTAIGTPANGRTFQDLLAEIQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC62</accession>
    <name>A0A2G1XC62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27590</name>
        <name evidence="3" type="ORF">CYQ11_18050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48833">
        <property type="protein sequence ID" value="PHQ48833"/>
        <property type="gene ID" value="BLA24_27590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14521">
        <property type="protein sequence ID" value="PPT14521"/>
        <property type="gene ID" value="CYQ11_18050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304834" evidence="1">
        <location>
            <begin position="28"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="17934" checksum="F81577416131A8B3" modified="2018-01-31" version="1">MRFARLIASAALSGAAVLATAAVPAQAAPQADRGPVQALCSTSSADFTVRNVSRPINHQLLTVTNTGSESCTLVKAPLLGFDNDTYVGAQAIEESAPQSVVTLAPGQSAYAGIRLSSADGSGENGRDVRTVHVFLDSGDGSEGGPDSIALPKGTWIDDSAAVTYWQSNASDALVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC96</accession>
    <name>A0A2G1XC96_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0309 protein BLA24_27490</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27490</name>
        <name evidence="4" type="ORF">CYQ11_18155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0309 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48815">
        <property type="protein sequence ID" value="PHQ48815"/>
        <property type="gene ID" value="BLA24_27490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14538">
        <property type="protein sequence ID" value="PPT14538"/>
        <property type="gene ID" value="CYQ11_18155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01240">
        <property type="entry name" value="UPF0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022951">
        <property type="entry name" value="UPF0309"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="36"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="25724" checksum="00474B8E739FC209" modified="2018-01-31" version="1">MSENKLAGQFFDAAIELLRRVRDEEAGNIAAAGAAMADAVAAGGRLFVFGAGHSSLPAQDVVYRAGGLALVNLLVVPGVIGVDVMPATLGSALERVDGLAGAVLDTSPVQAGDVLVVVSLSGRNSLPVEMALNARALGLKVVGVTSLAYARETKSRHASGTFLRDHCDIVIDSKIAVGDAELAAEGIAAPFAPASTVVTSAVMQAVVAAAAGELASRGVEPPMLRSGNVDGGHEWNGRVLEEYGDRIFFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB8</accession>
    <name>A0A2G1XCB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27840</name>
        <name evidence="2" type="ORF">CYQ11_17800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48876">
        <property type="protein sequence ID" value="PHQ48876"/>
        <property type="gene ID" value="BLA24_27840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14477">
        <property type="protein sequence ID" value="PPT14477"/>
        <property type="gene ID" value="CYQ11_17800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="8669" checksum="4FF06023026DFD66" modified="2018-01-31" version="1">MALLFIAKDPNTNGTQCPTAWVDDEAQEIVVQGWKAGEALLAQCRESGPIPESEAVVRLPIRMVPALREACDVADRLGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCF8</accession>
    <name>A0A2G1XCF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_27100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000155">
        <property type="protein sequence ID" value="PHQ48944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48944">
        <property type="protein sequence ID" value="PHQ48944"/>
        <property type="gene ID" value="BLA24_27100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="296"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="364" mass="37301" checksum="10E169FB1DD5D802" modified="2018-01-31" version="1" fragment="single">MFRTALRNVLAHKARLLMTVLAVMLGVAFVSGTLVFTSTISDAYRKSSEKGFTGVDVAIQIDRKEGGKAGPGAPKLTQGLLDRAASVPGVASVSASVAGSAAIADKHGELVGHGFSTQGGNYYAGKDGKDARYPLKDGRAPRTADEVALDSKTADRAGYKVGDTVRLSVDGPVLEQKVTGVFTTDDGNVAAGGSLALFDTATAQKLYAKPGEYSEILVKAQQGESQSALKAAIEKILPPGADAVTGKTLADDQAAAVEEGMGNMRTALLGFAAVALFVGVFIIANTFTMLVSQRTKEIALLRAVGASRRQVTRSVLVEALVVGAVAAVAGLVIGIGIGAALHPLMRSTGMLVPDGPLVVPPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM9</accession>
    <name>A0A2G1XCM9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_23090</name>
        <name evidence="11" type="ORF">CYQ11_22985</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48993">
        <property type="protein sequence ID" value="PHQ48993"/>
        <property type="gene ID" value="BLA24_23090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15362">
        <property type="protein sequence ID" value="PPT15362"/>
        <property type="gene ID" value="CYQ11_22985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="170"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="278"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="644" mass="70515" checksum="97E00098C72176E4" modified="2018-01-31" version="1">MSAPSVRPVSEREARQVAEAAREQDWKKPSFAKELFLGRFRLDLIHPHPTPPPDDVRRGEEFLAKLRDFCETRIDAARIEREARIPDETVNGLKELGALGMKIDVKYGGLGLTQVYYNKALCLVGSASPVVGALLSAHQSIGVPQPLKLFGTQEQKDTFLPRCARTDISAFLLTEPDVGSDPARLATTAVPDGDDYVLDGVKLWTTNGVVADLLVVMARVPKSEGHRGGITAFVVEAAAEGVTVERRNAFMGLRGIENGVTRFHQVRVPAAHRIGPEGAGLKIALTTLNTGRLSIPAMCVAGGKWSLKIAREWSAAREQWGKPIARHEAVGSKISFIAATTFALEGIVELSSQMADENRNDIRIEAALAKLYASEMGWLISDELVQIRGGRGYESAASLAARGERAVPAEQMLRDSRINRIFEGSTEIMHLLIAREAVDAHLSVAGDLIDPDKSLGDKARAGARAGGFYARWLPKLVAGPGQLPRTYSEFHPAGHRDLSGHLRYVERSSRKLARSTFYAMSRWQGRMETKQGFLGRIVDIGAELFAMSAACVRAEHLRVRGEHGSEAYELANAFCRQSRIRVEELFRRLWTNTDDLDRKVVSGVMAGSFEWLEAGVIDPSGDGPWIADATPGPAKAENVHRPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCN9</accession>
    <name>A0A2G1XCN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MDMPI N domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27435</name>
        <name evidence="3" type="ORF">CYQ11_18210</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48929">
        <property type="protein sequence ID" value="PHQ48929"/>
        <property type="gene ID" value="BLA24_27435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16643">
        <property type="protein sequence ID" value="PPT16643"/>
        <property type="gene ID" value="CYQ11_18210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="362" mass="38104" checksum="8FA403103AFB53CA" modified="2018-01-31" version="1">MRGAPVSAPRPGARPPHPVLKSLLGAWALAACSAEETAAVEEHLTDCAACADEAVRLRDAVALLHPEDSLDLDPTLRSRVLAGALGRRPARVPVPDWAAPYEAETARLDALLRDFGDSEWRAPVRLSWFDGRQPVEREVTVAGVIGHLTEVDGRLAGALDLPPPSPPPADGVPGEVRSAWRDQGRALVRAVSFAGGEVAGVPVAYGPLSLPLRDSFLDRAFECWVHAEDIAVAVDYPYEPPASSHLHHMIDLAARLLPTVIATRRRAGLAPPARGLVPVGAPGRALHLEIEGRGGGHWYIPLDSPAALGTPEGEVAHVALDGVEFCRLAAGHVSPGEAAAGSLGDEEAVQDVLYATASLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCR5</accession>
    <name>A0A2G1XCR5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_23215</name>
        <name evidence="11" type="ORF">CYQ11_22860</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49012">
        <property type="protein sequence ID" value="PHQ49012"/>
        <property type="gene ID" value="BLA24_23215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15344">
        <property type="protein sequence ID" value="PPT15344"/>
        <property type="gene ID" value="CYQ11_22860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="38347" checksum="BE0B9B3E5E89A7DA" modified="2018-01-31" version="1">MNDASWGAPPRAGHWGATDHGPSTRLRGEVPPAPAGPLHGAGDAAQTRPMPIVSDAGGDQDDRDRGAAHTGGPLFRDEQEPDIRPQEPAAPQGGKAKKSAGRDLRAAIGVGVGLGAVILASLFIYKPVFLGVIVLAVVVGLWELTSRLAERKGIKAPLVPLAIGGAAMIVAGYVSGTEGSWVAMAFTALAVLVWRMTESPDDYLRDVTAGIFVAFYVPFLATFVALMLAAGDGAWRVLTFLILTVVSDTGAYAVGWRFGRHKLAPRISPGKTREGLVGAVLFAMVAGALCMQFLIVDGVWWQGLLLGFAVAVSATLGDLGESMIKRDLGIKDMGALLPGHGGIMDRLDSLLPTAPVVWLLMVAFVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT6</accession>
    <name>A0A2G1XCT6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_23335</name>
        <name evidence="2" type="ORF">CYQ11_22740</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49032">
        <property type="protein sequence ID" value="PHQ49032"/>
        <property type="gene ID" value="BLA24_23335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15322">
        <property type="protein sequence ID" value="PPT15322"/>
        <property type="gene ID" value="CYQ11_22740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="275" mass="29333" checksum="1F5954D865303806" modified="2018-01-31" version="1">MTPTLVRRHRPSSTSPETRARDWAEIQERMLVPLYEAVYERLEAGPGTRLLSLGCGSGLALLMASARGADVCGVDEDERRLELARERLLPEGAPAGGTRLGLGGPETVLSPTGPLFNLITVFDPLFSAGGDPRGLAGALARAAGCAERGTPVVLAGWGPHERCAASAALRVAARLADPMCAPARWRPSRRDDLENLAREAGLTPDGSGRVSCPYGYADMSSAVRGLLSTGAFDAAARATDEEQVVKELIEALHPYLRTDGTVWMPNVFRYLIART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCX2</accession>
    <name>A0A2G1XCX2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmB</name>
        <name evidence="5" type="ORF">BLA24_23460</name>
        <name evidence="6" type="ORF">CYQ11_22610</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003957616.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49051">
        <property type="protein sequence ID" value="PHQ49051"/>
        <property type="gene ID" value="BLA24_23460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15303">
        <property type="protein sequence ID" value="PPT15303"/>
        <property type="gene ID" value="CYQ11_22610"/>
    </dbReference>
    <dbReference type="GeneID" id="57802641"/>
    <dbReference type="GeneID" id="61469420"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6720" checksum="8F0CBCAE1142C7E0" modified="2018-01-31" version="1">MAANCDVCGKGPGFGNNISHSHRRTSRRWNPNIQRVRAVVGRTPKRLNVCTSCIKAGKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD12</accession>
    <name>A0A2G1XD12_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_23710</name>
        <name evidence="8" type="ORF">CYQ11_22365</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49091">
        <property type="protein sequence ID" value="PHQ49091"/>
        <property type="gene ID" value="BLA24_23710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15263">
        <property type="protein sequence ID" value="PPT15263"/>
        <property type="gene ID" value="CYQ11_22365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="517" mass="53010" checksum="9E4D1ABDD5A6153E" modified="2018-01-31" version="1">MTNPSAPLAGRREWTAFVVLLLPLLLVSMDVSVLFYAVPVISEDLGVTSTQQLWIFDVYAFALAGLLITMGSLGDRIGRRKLLMAGAVAFGAASVAAAYARDAETLIAARAVLGVGGATLMPSTMALVRNMFRDDKQRSKAVGIWSGAMAGGIALGSVVGGVLLEHFWWGSVFLINVPAMVLLLVLTPVLVPEFKDPRPGPFDLLSVPLSMGAVLPVIYGLKQIAADGFSLPMALCVAAGLAVGWLFVRRQRTRRDAMISRELFRHRAFGLGVTVNTLASVGMMGSAYFTTQYLQSVLGKSPLDAALWGLLPSLAVAAVAPLATTAAQKADKALVIAAGFLMGAAGYGLLALSDTDSLALTLAAAALISCGIVSVMAPASDMTLATAPPEKAGSAAAVLETGQEFGNALGMAVFGSVGTAVYRRDVTDALPADLPQGTLEAVRETLGGAVGVAARLPGRTGGAVLGAAREAFTHGMVVASVGGAVLLVLAALLSVTALRRAGDTSTAAAPEPAPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD36</accession>
    <name>A0A2G1XD36_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_23955</name>
        <name evidence="7" type="ORF">CYQ11_22115</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49132">
        <property type="protein sequence ID" value="PHQ49132"/>
        <property type="gene ID" value="BLA24_23955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15219">
        <property type="protein sequence ID" value="PPT15219"/>
        <property type="gene ID" value="CYQ11_22115"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="5">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="224"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="383" mass="41590" checksum="4294CD838A347C43" modified="2018-01-31" version="1">MLAGCATVGPPKTALTDDARPPAQLVHVVPHDGARNVSAAERFEVRAPRGRLERVRVSAFRDGIQLTVPGRISADRHRWLPADRGHLRLGARYAVDVVAVDSSGRRTARHSGFTTYVPQHRFIGYFTPEPQSVVGTGMIVSFGFSRPITDRAAVERAIRVTAQPPTEVAAHWFGPARLDFRPRTYWKPGTVVTLDLKLRDVRGAEGVYGLQQKTVRFVVGRRQFSTVDAATHTMRVVRDGKAPVTLPVTAGGPGNETYNGKMVISEKFDMTRMNGDTVGFGGEYDISDVPHAMRLTATGTFLHGNYWAPADAFGATNTSHGCIGLRDTQGGSLSSPAGWFFSGSLVGDVVEVVHSGDRQVAPDNGLSGWNMSWRDWRAGSALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD98</accession>
    <name>A0A2G1XD98_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_24355</name>
        <name evidence="6" type="ORF">CYQ11_21715</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49202">
        <property type="protein sequence ID" value="PHQ49202"/>
        <property type="gene ID" value="BLA24_24355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15148">
        <property type="protein sequence ID" value="PPT15148"/>
        <property type="gene ID" value="CYQ11_21715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="27663" checksum="08AE40239A0D5BFC" modified="2018-01-31" version="1">MDSIHTSGLARSFATPHGPVVAVRGIDLTVRRGEILGFLGPNGAGKTTTLRMLTTLLAPTGGTATVAGHDLVRDPEGVRRSTGYVAQSGGVDPAVSVREELVTQGRLYRLTKRLAQDRAEELATALDLVDLLERPCGTLSGGQRRRLDIAMALAHRPEVLLLDEPTTGLDPRSRADLWDLVRRVRSEWGTTILLTTHYLDEADALADRLVVVDKGAIAAEGTPAELKSRHGGSPDATLQDAFLAVTGRAPAPPHTTPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDD7</accession>
    <name>A0A2G1XDD7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24645</name>
        <name evidence="3" type="ORF">CYQ11_21425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49253">
        <property type="protein sequence ID" value="PHQ49253"/>
        <property type="gene ID" value="BLA24_24645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15095">
        <property type="protein sequence ID" value="PPT15095"/>
        <property type="gene ID" value="CYQ11_21425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1066" mass="111547" checksum="AD6BB1EACA71C810" modified="2018-01-31" version="1">MTAPPDHRLGQLVARLRAAAWDLTAEELADAVWLAQWVSPAGAAGQAPGGRPPAADRPERTASDAGPARPGAAGPLAPDVPGVSGPAGGAAAERLAERSDPVALYAHGGGRSEPVGAFPIRIPMASSLPGLLGLQRALRPLRGYRTLAAPVRGPLDEDATADRGARSGVLEPVFRPGEGRSVSMQLLMDTSPSMAVWERMLEELHQTCAQLGAFRDVRVRYLHRSADGAPLIGTTAEPGPPGSARHLCPRPAGQFRDPTGRRLTLVISDCVGPLWQEGTAQRLLHDWAHTSPLAVVQPLPPRLWPRTALPAEAGLLTRDPATGGRLHFTPEGYGPGPAPGALPVPVLLPTRDALGTWARLLSGPGRSAVRGAAGWLLPGHPARPAPPHGERDGRTAGELLRAFRAGASPGALRLAVHLAAVPLTLPVMQVVQRAMLPDTGPMELAEVLLSGLLRKLPGADREEPGPWAGARYEFADGVREMLLQSLDRSAAALVLKHCSDYVERHFGKGARNFSALAAAQLSGTQPDPGPPQASDEPGGPAEAGAAEPELFAEVPARVVRWYRPVAVEGGPVAEAERLLRLWHVQGDPGLLHEARALAEPAAGLPFPVGTGRTGPDPAPGGAEPAPAPEAVRARLVLGGVLCALAGTESVRHDPGRRHTILTEAVALLTEARDHTPPGSGRHTEAALELAAAQYAAWLADGDPERLRDAERTLRALSPGTPARHLRLGRVLLALAAAGDEPAGRAGAAAAELRTGHELLESDGAPDAQRGAALLDLAAALRLSGAPAAETLAALARAEETVADDLQRLRCRTEQARAHAAAGDGPAADDAYAGAVALTARDSLGRCELLTEWGESLLGRAEEVAGPRGAIRGGPPSADDAAAAPVPAPDPVGRAEAVLREALTVSPGRWPLRARTQLMLGRALTLRYGRQGFLPDLYESCHLLEQAARRAPDPATRAEAWLRLGYARLLLSRQPGAMPVAEAATAFDAAVKEARRLPTPDGPGSVTAARALHGHGVALERMGLRGAALAAYREARREWWDLTGRLADVPWDEVQATRECVTRLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDV9</accession>
    <name>A0A2G1XDV9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA 2-methylthio-N6-isopentenyl adenosine(37) hydroxylase MiaE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25255</name>
        <name evidence="2" type="ORF">CYQ11_20815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49359">
        <property type="protein sequence ID" value="PHQ49359"/>
        <property type="gene ID" value="BLA24_25255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14993">
        <property type="protein sequence ID" value="PPT14993"/>
        <property type="gene ID" value="CYQ11_20815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="244" mass="26255" checksum="1B171809F7EF76EE" modified="2018-01-31" version="1">METSDTPETAIEPTGIAAQDWAHASADPQYRAAVVDLLGALAYGELAAFERLAEDAKLAPTLDDKAELAKMAAAEFQHFQRLRERLEAIEVEPTGAMEPFAAALDEFHRQTAPSDWLEGLVKAYVGDSIASDFYREVAARLDSDTRALVLGVLDDTGHASFAVEKVRAAIEAEPRVGGRLALWARRLMGEALSQAQRVVADRDALSTMLVGGVADGFDLAEVGKMFSRITEAHTKRMAALGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE32</accession>
    <name>A0A2G1XE32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25980</name>
        <name evidence="3" type="ORF">CYQ11_20085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49488">
        <property type="protein sequence ID" value="PHQ49488"/>
        <property type="gene ID" value="BLA24_25980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14861">
        <property type="protein sequence ID" value="PPT14861"/>
        <property type="gene ID" value="CYQ11_20085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="148" mass="15738" checksum="EAEE1338085377FC" modified="2018-01-31" version="1">MTGEGRSVTVTIKCGAAQEDPQLSFRGPSAEVQEDIAACFGFDRKSVSGLTLHELVAEANQLAQGASTVMRGFPGARVVPQGDERNESAQSTTPPAGHQETENPLLEQITACATTDDLRRLWATNQHAFTDPAVMDAWKARGRALAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE68</accession>
    <name>A0A2G1XE68_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_26215</name>
        <name evidence="10" type="ORF">CYQ11_19425</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49527">
        <property type="protein sequence ID" value="PHQ49527"/>
        <property type="gene ID" value="BLA24_26215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14753">
        <property type="protein sequence ID" value="PPT14753"/>
        <property type="gene ID" value="CYQ11_19425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="20561" checksum="950D07D0A6E68871" modified="2018-01-31" version="1">MLTVGDKFPEFDLTACVDLDADKAFAQIDNKTYEGKWKVVFFWPKDFTFVCPTEIAAFGKLNDEFADRDAQILGVSGDSEFVHHAWRKDHADLRDLPFPMLADAKHELMQACGVEGEDGYAQRAVFIVDPNNEIQFVMVTAGSVGRNPKEVLRVLDALQTDELCPCNWSKGEETLDAVKLLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEQ1</accession>
    <name>A0A2G1XEQ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_23700</name>
        <name evidence="5" type="ORF">CYQ11_22375</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49700">
        <property type="protein sequence ID" value="PHQ49700"/>
        <property type="gene ID" value="BLA24_23700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16725">
        <property type="protein sequence ID" value="PPT16725"/>
        <property type="gene ID" value="CYQ11_22375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="402" mass="43436" checksum="03684EAEC2AE8265" modified="2018-01-31" version="1">MTDTPSTAPSAPAFPQDRGCPYHPPAQYPELAARGPVGRMTLYDGREVWAVTGHAEARALLADPRLSSDRQNPSFPVVVPRVEDQAAVGIPLLGVDDPEHARQRRMLIPRFSLKRVAAMRPRIQETVDGLIDAMLDEGPEAELVSAFALPVPSMVICQLLGVPYADHEFFEAQSRALLASETADEAAVARESLKAYLHRLVDAKEAHPGDGLLDELIADRLADGQLDRDELVMLVLVLLVAGHETTANMIALGTFTLLEHPAQLAALTAEPGLMPGAVEELLRYLSIADGMVRLATEDIELGGHTIRAGDGVLLPTSVINRDSGAYEQPDALDVRRVARHHVAFGYGVHQCLGQNLARAEMEIALTTLFARIPTLRLAVAPDEVPVKPGSTLQGLYALPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF29</accession>
    <name>A0A2G1XF29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_19590</name>
        <name evidence="6" type="ORF">CYQ11_11205</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49846">
        <property type="protein sequence ID" value="PHQ49846"/>
        <property type="gene ID" value="BLA24_19590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13378">
        <property type="protein sequence ID" value="PPT13378"/>
        <property type="gene ID" value="CYQ11_11205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="68"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="213" mass="22457" checksum="56EDBE4AD3DB2A1D" modified="2018-01-31" version="1">MTAETSQTLDRGLRVLKLLADTDHGLTVTELSTKLGVNRTVVYRLLATLEQHAFVRRDIGGRARVGLGVLRLGRQVHPLVREAALPALRSLAEDIGATAHLTLVDGAEALAVAVVEPTWTDYHVAYRAGFRHPLDRGAAGRAILAARRGEVDDPGYALTHGELEAGASGAAAPLLGVSGIEGSVGVVMLADTIPQRVGPRVMEAAKEVADALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFN6</accession>
    <name>A0A2G1XFN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20735</name>
        <name evidence="2" type="ORF">CYQ11_10045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50037">
        <property type="protein sequence ID" value="PHQ50037"/>
        <property type="gene ID" value="BLA24_20735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13185">
        <property type="protein sequence ID" value="PPT13185"/>
        <property type="gene ID" value="CYQ11_10045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="129" mass="14186" checksum="8D5ED807E9565694" modified="2018-01-31" version="1">MKILGLHQETWPSAPGAVGSIRDDVTDSPCPDEKEIASYLRGGHVLFASMGVVDDVLGSGESIVGGGSLFTDGEWVWRGDLWFYVTTYHLLLPDEFVNKARAAGFHVPAVEQDRLIELTDEIQAIRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS5</accession>
    <name>A0A2G1XFS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_20850</name>
        <name evidence="6" type="ORF">CYQ11_09930</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50055">
        <property type="protein sequence ID" value="PHQ50055"/>
        <property type="gene ID" value="BLA24_20850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13166">
        <property type="protein sequence ID" value="PPT13166"/>
        <property type="gene ID" value="CYQ11_09930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="241" mass="26766" checksum="78DAF3B75085DD92" modified="2018-01-31" version="1">MTRVLVVEDDPDLALALRVLLARAGHEAVHADDGREALRLLFAERPGLMILDIGLPGLDGWEVLERTRDLSDLPVLLLTARGAESDRVRGLRAGADDYLPKPFGNDELLARVEALLRRSAPARWAGDSFGGDGLRLVPERRSAVWHGHEARLSDIEYRLLQVLVRNRGRVITTDQLLDRVWDDPEGTGRERVKFAVLRLRRKLRQAAGDEAADPLEAVRGLGYRYRAEGAGREAAHEAEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGG0</accession>
    <name>A0A2G1XGG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22475</name>
        <name evidence="3" type="ORF">CYQ11_08315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50317">
        <property type="protein sequence ID" value="PHQ50317"/>
        <property type="gene ID" value="BLA24_22475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12896">
        <property type="protein sequence ID" value="PPT12896"/>
        <property type="gene ID" value="CYQ11_08315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="7770" checksum="0DD53ABF9C92FBDC" modified="2018-01-31" version="1">MSYRDRRSTSDAAEDQRLTGKLLHDAQTYSYRDDADPEFTSIVMRGCGTSQRGDYPPKGHDYPRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGG4</accession>
    <name>A0A2G1XGG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_22535</name>
        <name evidence="8" type="ORF">CYQ11_08255</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50326">
        <property type="protein sequence ID" value="PHQ50326"/>
        <property type="gene ID" value="BLA24_22535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12887">
        <property type="protein sequence ID" value="PPT12887"/>
        <property type="gene ID" value="CYQ11_08255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="155" mass="16524" checksum="5182D6F2E352D97E" modified="2018-01-31" version="1">MDNRQAIGSWLSGPRAAAEDMGVEFGHQGERLGLPQSGPGSIAPVGRRVVALLVDWALCMLIAYGLLAGGEPQRAGNWAVLIFFVLSVLTVGTVGCTPGKRLLGLRVAAEGGGRLSLPRVLLRSLLIVLVVPAVVWDRDTRGLHDRLTRSVQVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGM3</accession>
    <name>A0A2G1XGM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22310</name>
        <name evidence="4" type="ORF">CYQ11_08475</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50289">
        <property type="protein sequence ID" value="PHQ50289"/>
        <property type="gene ID" value="BLA24_22310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12925">
        <property type="protein sequence ID" value="PPT12925"/>
        <property type="gene ID" value="CYQ11_08475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304867" evidence="1">
        <location>
            <begin position="32"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="530" mass="56369" checksum="45C963B11F499775" modified="2018-01-31" version="1">MTAIRPRAAWMTGLLASAVTASVLAGAPAHAIAGQPVAEGKYSSVARLDIDGRRSCSATLVERQWLITAASCFADDPAKGYRINSGAPQRKTTATIGRTDLTREDKGTVVDVVELVPREDRDLVMARLAQPVDGIKTVALPDHAPMAGETVQALGYGRTKDEWVPDRLNVADFKVDSVSGGTVRISGTSPDAAVCQGDTGGPTLDAAWHLMGVHSTSGQAGCFGADESETRHTASEARVDDIVDWIQGVASRDVLARPNWKDAVHVVAGDFTRRHSLVGTGRKDLFVVWADGSASIFERSYHKDAKRPFATEHKVAPKGSYWKNAEAITGTRVTDSPSSGSASDGLTVRWNTGKLSTYTHADEYGFFEEKTLASSNSWKNARSIAAGRHSANGLRDDLSVLWADGSWSTYTDTGVNGVSKETQITGKTEALIGGQLAAGSFTGKDRDDLVVRWPNGAADALGGFEVNGDYGQEVNLRPQGSAWKYAQILTAGSFGGGYGEDLLVRWADGNVSYYADVDASGTHDEVQLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH24</accession>
    <name>A0A2G1XH24_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17150</name>
        <name evidence="2" type="ORF">CYQ11_16125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50544">
        <property type="protein sequence ID" value="PHQ50544"/>
        <property type="gene ID" value="BLA24_17150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14202">
        <property type="protein sequence ID" value="PPT14202"/>
        <property type="gene ID" value="CYQ11_16125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046300">
        <property type="entry name" value="DUF6415"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19979">
        <property type="entry name" value="DUF6415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="121" mass="12995" checksum="E964DF8F0B44189C" modified="2018-01-31" version="1">MTAPVHEHAFDEATVQAVIRRALDRLPLADTVDNLIAALCWHTERLLPAVETKDWSAHGQGELVTVIVDGVRKKLDARPASGAVAAARAVYAQEVARACRALLGLALVEPGDEERLRGGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH51</accession>
    <name>A0A2G1XH51_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">BLA24_17255</name>
        <name evidence="13" type="ORF">CYQ11_16020</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50563">
        <property type="protein sequence ID" value="PHQ50563"/>
        <property type="gene ID" value="BLA24_17255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14183">
        <property type="protein sequence ID" value="PPT14183"/>
        <property type="gene ID" value="CYQ11_16020"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="22824" checksum="714BEA06F7682086" modified="2018-01-31" version="1">MRIHVVDHPLVAHKLTTLRDKRTDTPTFRRLADELVTLLAYEATRDVRTEQVSIESPVTATTGVRLSHPRPLVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRNEETLKAETYATRMPEDLSGRQVYVLDPMLATGGTLVAAINELISRGADDVTAICLLAAPEGVEVMERELKGAPVTVVTASVDERLNEHGYIVPGLGDAGDRMYGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHG5</accession>
    <name>A0A2G1XHG5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17920</name>
        <name evidence="3" type="ORF">CYQ11_15355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50672">
        <property type="protein sequence ID" value="PHQ50672"/>
        <property type="gene ID" value="BLA24_17920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14073">
        <property type="protein sequence ID" value="PPT14073"/>
        <property type="gene ID" value="CYQ11_15355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="205" mass="22739" checksum="6CEDBBA6FAC5FE49" modified="2018-01-31" version="1">MGRRLVPLTLDNLPDLPQRCRACVFWELDPVSGEAALRAGRPELEKEAWISAVLLEWGSCGRVVYVDDAPVGFVLYAPPAYVPRSTAFPTSPVAADAVQLMTAWLTPSFQGQGLGRMMVQTVAKDVLRRGFKAIEAFGDARWKEPACVLPADHLLAVGFKTVRPHPRYPRLRLELRSALSWKEDVELALDRLLGAVQKEPALRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHP6</accession>
    <name>A0A2G1XHP6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18415</name>
        <name evidence="2" type="ORF">CYQ11_14865</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50753">
        <property type="protein sequence ID" value="PHQ50753"/>
        <property type="gene ID" value="BLA24_18415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13989">
        <property type="protein sequence ID" value="PPT13989"/>
        <property type="gene ID" value="CYQ11_14865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="134" mass="14351" checksum="CB7EC73DD57E289D" modified="2018-01-31" version="1">MFDKRTGLTGDTGKRITVSIHADDELGGRRLVRQLRSLPGVHVVRGDEVPSVDLLLMGRHDADAPGTLRELARGGRAPLVVVADDLGESELMAVAEYGVRAVLWGHRLTPGRLSRAVHEAAGCCPKLPMVTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHY4</accession>
    <name>A0A2G1XHY4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ORF">BLA24_16585</name>
        <name evidence="5" type="ORF">CYQ11_16700</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004940393.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50858">
        <property type="protein sequence ID" value="PHQ50858"/>
        <property type="gene ID" value="BLA24_16585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16614">
        <property type="protein sequence ID" value="PPT16614"/>
        <property type="gene ID" value="CYQ11_16700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19202" checksum="539CF5CB764CE454" modified="2018-01-31" version="1">MGTDLKSVLITKEEIDAKLAELAAKIDAEYAGKDLLIVGVLKGAVMVMADLARALSNPVTMDWMAVSSYGAGTQSSGVVRILKDLDTDIKGKHVLIVEDIIDSGLTLSWLLSNLGSREPASLNVVTLLRKPEAAKVAIDVKWVGFDIPNEFVVGYGLDFAEKYRNLPFVGTLAPHVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI29</accession>
    <name>A0A2G1XI29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17585</name>
        <name evidence="8" type="ORF">CYQ11_15690</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50886">
        <property type="protein sequence ID" value="PHQ50886"/>
        <property type="gene ID" value="BLA24_17585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16586">
        <property type="protein sequence ID" value="PPT16586"/>
        <property type="gene ID" value="CYQ11_15690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="305" mass="32181" checksum="4996D6DFF816B086" modified="2018-01-31" version="1">MRPETTTTQGTAAGGAPDVIHNIGYRNYDGPRLGRGYARRSLFSQSLRGAYGLGRSAKSKVLPMILFGVMCLPAAIMVAVAVTTKMDRLPMEYTRYAIYLQAVIGLYLASQAPQAVSRDLRFRTVPLYFSRPIERSDYVAAKFAAMTSAVFILTAAPLLVLYAGALLAKMDFADQTKGFAQGLVSVALLSLLFAGIGLVVAALTPRRGFGVAAVIAVLTISYGAVSTIQGIALNSDNTQVISWLGLFSPITLIDGVQTAFLSATTAFPGGHGPGTGAGAVYLLVLLAVIAGSYGLLTRRYRKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIC8</accession>
    <name>A0A2G1XIC8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14380</name>
        <name evidence="4" type="ORF">CYQ11_13695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50977">
        <property type="protein sequence ID" value="PHQ50977"/>
        <property type="gene ID" value="BLA24_14380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13801">
        <property type="protein sequence ID" value="PPT13801"/>
        <property type="gene ID" value="CYQ11_13695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758864" evidence="2">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="17359" checksum="A7D425A3CB9FBD85" modified="2018-01-31" version="1">MRKAVQITGAALIAAVLMTGCSKSSDDKGGDKGKETGATAPADPAKQPSGAPAADKPANVKAADLSGGWSKGKLSDQSLLILSFASNTVMLSGKTACSGKVNDTAQPVTLDITHCQDGSTEYGKGTVKSFDGKSLTISWASGKEDTLTKTVGADGKPAGLPAGLPTNIPVKPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XID4</accession>
    <name>A0A2G1XID4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leupeptin-inactivating enzyme 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_14425</name>
        <name evidence="8" type="ORF">CYQ11_13650</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50985">
        <property type="protein sequence ID" value="PHQ50985"/>
        <property type="gene ID" value="BLA24_14425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13793">
        <property type="protein sequence ID" value="PPT13793"/>
        <property type="gene ID" value="CYQ11_13650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758356" evidence="5">
        <location>
            <begin position="44"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="6">
        <location>
            <begin position="341"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="459" mass="47430" checksum="FD93831EEE49F49B" modified="2018-01-31" version="1">MPELTGPTLPTPPRRTRTAATWLATGAAVTAALFGAASVPATAAPTAATAGPAAARSAAAPDISVADVKAHLNQLQSIATANGGNRAHGRSGYKASIDYVKGKLDAAGFTTTVQQFTTGGQTGYNLIADWPGGDANHVVFAGSHLDSVTRGPGINDNGSGSAGILEVALTVAKQGYKPDKHLRFGWWGAEELGMIGSQNYVRQLPAAERAKIDAYLNFDMIGSPNPGYFVYDDDARLEGVFKDFFAARKIATEIETEGDGRSDHAPFKDAGVAVGGLFSGADYTKTAAQAQKWGGTAGQPFDRCYHSSCDTSANIDDTALDNNSDAIAHAIWTLSGGGGTTPPSGTSFESKSQVAIPDAGAAVESPITVTGVSGNAPSALKVVVDIRHSYRGDLVVDLVGPSGKTYRLKDSSANDSAADVKTTFTVDASGEVANGTWKLRVQDVAAQDSGALNSWKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM0</accession>
    <name>A0A2G1XIM0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_15085</name>
        <name evidence="11" type="ORF">CYQ11_12985</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51098">
        <property type="protein sequence ID" value="PHQ51098"/>
        <property type="gene ID" value="BLA24_15085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13679">
        <property type="protein sequence ID" value="PPT13679"/>
        <property type="gene ID" value="CYQ11_12985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="8">
        <location>
            <begin position="24"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="9">
        <location>
            <begin position="409"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="573" mass="62611" checksum="28F3E0839F690DC1" modified="2018-01-31" version="1">MRTATLGPAERGEALARMAERELDILVVGGGVVGAGTALDAATRGLATGLVEARDWAAGTSSRSSKLIHGGLRYLEMLDFALVREALKERGLLLQRLAPHLVKPVPFLYPLQHRGWERFYAGSGVALYDAMSVSSGHGRGLPVHRHLSRRNALRVAPCLRKDALVGALQYYDAQMDDARYVTTIVRTAAAYGADVANRTRVVGFLREGERVVGARVRDLEAPSGEKGAEFEIRARQVVNATGVWTDDTQRLIAERGQFHVRASKGVHLVVPKDRIHSTSGLILRTEKSVLFVIPWGRHWIIGTTDTDWDLDKAHPAASSADIDYLLEHVNSVLSVPLTRDDVQGVYAGLRPLLAGESDATSKLSREHTVAHPVPGLVVVAGGKYTTYRVMAKDAVDEAVHGLAQRVADCVTEDVPLVGAEGYRAMWNGRAQIAQRTGLHVARVEHLLNRYGSLVDEVLAYVLADPSLGRPLAGADDYLRAEIVYAASHEGARHLDDVLTRRTRISIETFDRGTRSAREAAELIAPVLGWDTAQVEKEVEHYEKRVEAERESQLQPDDQTADAARLGAPEIQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIS2</accession>
    <name>A0A2G1XIS2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">BLA24_14765</name>
        <name evidence="7" type="ORF">CYQ11_13305</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51039">
        <property type="protein sequence ID" value="PHQ51039"/>
        <property type="gene ID" value="BLA24_14765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13738">
        <property type="protein sequence ID" value="PPT13738"/>
        <property type="gene ID" value="CYQ11_13305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="13344" checksum="08FA71D6FFA48208" modified="2018-01-31" version="1">MIQQESRLRVADNTGAKEILCIRVLGGSGRRYAGIGDVIVATVKDAIPGGNVKKGDVVKAVIVRTVKERRRPDGSYIRFDENAAVVLKNDGDPRGTRIFGPVGRELREKKFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIX7</accession>
    <name>A0A2G1XIX7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_15730</name>
        <name evidence="7" type="ORF">CYQ11_12345</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51204">
        <property type="protein sequence ID" value="PHQ51204"/>
        <property type="gene ID" value="BLA24_15730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13572">
        <property type="protein sequence ID" value="PPT13572"/>
        <property type="gene ID" value="CYQ11_12345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="398" mass="40639" checksum="7631E642EF9B51B4" modified="2018-01-31" version="1">MNLLDLLLMLVVLGYAVSGYRRGLIASAVLLAGFLGGAVLGVWALPHALEPFEAGTSTAAVVAVLVVLIPAALGHALAGRLAWRLRRKLTWAPVRGVDGVGGAAVNSLAVLLVGWVAASVLVSANSPLLTRQIRESTLLGAVQEAMPEQAPTWFSRTTDALAGAGFPQVFNPFENEPATSVPKPSEDAVTAAAKTAARRSVVKVEGVADVGGGRRGQEGSGFVYAHEHVMTNAHVVAGVDDPTVRVGGVGRAYKAKVVLFDPRTDVAVLDVPGLDAPVLPFDTSAGRGDAAVVAGFPENGGLDLRAAVVAGEVRAKGQDIYGDGVTTREVYSVRSTVRPGNSGGPLLTPGGKVYGVVFARSTADAETGYVLTAGQVAADASRAARASTPVSTGSRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ04</accession>
    <name>A0A2G1XJ04_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low temperature requirement protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15545</name>
        <name evidence="4" type="ORF">CYQ11_12530</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51171">
        <property type="protein sequence ID" value="PHQ51171"/>
        <property type="gene ID" value="BLA24_15545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13605">
        <property type="protein sequence ID" value="PPT13605"/>
        <property type="gene ID" value="CYQ11_12530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="43427" checksum="F1B416FE5B0330D7" modified="2018-01-31" version="1">MSEQPPPRPSGVLRRMTARGRDEEHRTATPLELLFDLCFVVAVAQAGRQLVHALAEGRPGHGVTGYLMLFFAIWWAWVNFTWFASAYDTDDVLYRVVTLVQIAGVLILAAGVPRAFADSDFTLVWSGYLVMRLALVSQWLRAAHATEGAERRTALRYAAGVSLCQVGWLGVLLLPDHAKPWVFLVMAFVEMAVPVCAELGGPTAWHPHHVAERYGLFTIIVLGETVAAATVAVQSAVDEHEALDELLPIAAGGLLLIFAAYWIYFAVPIHLHLVSNRQAFAWGYGHYLVFGSAAAIGAGIEVAVEETTGKAHVPALAAAASVTVPAALFMLSVWLVHARHHKRGLPQHLTLPVSAVAVLACTFAGRFATLLAGVVASATVVVGVTLSTRGARESAARVRQGAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ39</accession>
    <name>A0A2G1XJ39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_16050</name>
        <name evidence="11" type="ORF">CYQ11_12025</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51262">
        <property type="protein sequence ID" value="PHQ51262"/>
        <property type="gene ID" value="BLA24_16050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13512">
        <property type="protein sequence ID" value="PPT13512"/>
        <property type="gene ID" value="CYQ11_12025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304750" evidence="7">
        <location>
            <begin position="44"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="297"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="483"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="737"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="836" mass="86578" checksum="4FB51C7BD6F8136D" modified="2018-01-31" version="1">MFRTALRNVLAHKARLLMTVLAVMLGVAFVSGTLVFTSTISDAYQKSSQKGFTDVDVAIQPHRQDRDNGAPGEAPKLTQQLLDKVRAVPGADSTTGSVSGFAAIADKKGKLAGQGFTSAGANYFPGKDGKDTRYPLKDGRAPKAAGEIALDSKTADRTGYKVGDTVRLSVDGPVLEQKVTGVFTTDDGNVAAGGSLALFDTATAQKLYAKPGEYSGITVKATAGTSQTALKSAIDKVLPADAEATTGKELADEQAKFISQAMDGMKTGLLIFAGISLFVGVFIIANTFTMLVAQRTKELALMRAVGASRRQVTRSVLIEAFLVGAVAAVAGLLAGTGIGAGLRALMGGQVPDGPLVVPPSAIIASFGVGIAVTMLAAWLPGRRAAKIPPVAAMSSVHAVATTRSLVVRNTIGAALTAVGAVLSLTATSESMLGLGAGVLLIGVFVLTPLLSRPMIAAAAPVLRVFGISGKLARQNAVRNPRRTAATASALTIGLTLITGLTVIAGSVQQGIDKMAKEALKADYVVSMASMTSLSPDVAKKLSGLDEVTAASPMRDSASRIDGERESLTGVNGKTIGKLTDLDFTSGSLAGLSGDKAVIDDATARSRGWKLGSTLAVTYEDGKQDKLTVSGVYKGNDLIRGVLVDTSTVDPHQSAASDQRVLVKTKGGASEGTKNTLEKALGDNPAISVQSKQDVSDSIAKQINLMLNMLYGLLAMAVIVAVLGVVNTLAMSVFERQQEIGMLRAIGLDRKGIKRMVRLESLVISLFGGVLGIGLGVFFGWAAGEQIKTALATYELVLPWGRMGLFLLLSAVVGVLAALWPARRAAKLNMLQAIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ49</accession>
    <name>A0A2G1XJ49_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">BLA24_16020</name>
        <name evidence="14" type="ORF">CYQ11_12055</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51256">
        <property type="protein sequence ID" value="PHQ51256"/>
        <property type="gene ID" value="BLA24_16020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13518">
        <property type="protein sequence ID" value="PPT13518"/>
        <property type="gene ID" value="CYQ11_12055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="139"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="426" mass="45570" checksum="2317D96DDED12F0F" modified="2018-01-31" version="1">MPSIDVVVAREILDSRGNPTVEVEVGLDDGSTGRAAVPSGASTGAFEAIELRDGDPNRYLGKGVEKAVLAVIEQIGPELVGYDATEQRLIDQAMFDLDATDNKGSLGANAILGVSLAVAHAASEASDLPLFRYLGGPNAHLLPVPMMNILNGGSHADSNVDIQEFMIAPIGAESFSEALRWGTEVYHTLKKVLKGRGLSTGLGDEGGFAPNLGSNREALDLILEAIKEAGYTPGQDIALALDVAASEFYKDGVYTFEGKDRTAAEMTEYYAELVDAYPLVSIEDPLFEDDWAGWKTITEKLGTKVQLVGDDLFVTNPERLARGIEENSANALLVKVNQIGSLTETLDAVELAQRNGFKCMMSHRSGETEDVTIADLAVATNCGQIKTGAPARSERVAKYNQLLRIEEILDDAAVYAGRSAFPRFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ87</accession>
    <name>A0A2G1XJ87_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3499 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16400</name>
        <name evidence="3" type="ORF">CYQ11_11675</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51318">
        <property type="protein sequence ID" value="PHQ51318"/>
        <property type="gene ID" value="BLA24_16400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13456">
        <property type="protein sequence ID" value="PPT13456"/>
        <property type="gene ID" value="CYQ11_11675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="146" mass="15414" checksum="5676F01F7285BA86" modified="2018-01-31" version="1">MSRRGPLKSAVPSNLVSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLAVDDGPARPSGDDLEALANAVREAARPQERPAAPGGAAGAVAPHVRGADPMEVARRGHLRVLRSPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJF8</accession>
    <name>A0A2G1XJF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_15960</name>
        <name evidence="5" type="ORF">CYQ11_12115</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51367">
        <property type="protein sequence ID" value="PHQ51367"/>
        <property type="gene ID" value="BLA24_15960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16510">
        <property type="protein sequence ID" value="PPT16510"/>
        <property type="gene ID" value="CYQ11_12115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304697" evidence="2">
        <location>
            <begin position="24"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="3">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="584" mass="59972" checksum="027928EDE9177844" modified="2018-01-31" version="1">MCAALLVAGLTTAAVGASPPHRAVGGGDPSPGSDNPQSRPHGNPNLTLPDLRPKPGASGKPADGQLPPGGENSGIPATALAAYKNAETIAKEKYPNCHIPWQLVAGIGKVESEHGALGGRMNPDGRTEHRILGPRLTGGEFARITDTDGGRWDGDKEYDRAVGPTQFIPSTWQTSGADGNGDGVQDPNNIFDAAAATAGYLCSYNRDLTRASDLDKAILSYNNSREYVKAVLAWARTYEGGSVSVLPDPTAGAPYNPGASPTPSQPGGGSGTGNSGSTGHPGTSKPSESGKPSQSGQRPKPGTPGGSGKPTEPNKPTNPGDSGKPNKPGGGDNGSDTKPKPPAPVTRLDRVGDDKLEATAGETFTQQPRVRALDRDGKPAPDGTVVRFEVIGLETGARFPDDQRTALVRTGKDGTATAPKLLAGDKPGTFTVRAMVEGKDGAKIAPVDYAATVKAAPAPHADTITPVDESPLKAAPNSSFTKKIQLKALAAKQPVAGTVITATVLDADGKTPAKTGPYVKDADGKPRRTFTLAKTDENGLVTLPALYTDGQTGTFILKLTTEDGVTRTLTLTVETPAAPQKPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL9</accession>
    <name>A0A2G1XJL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16105</name>
        <name evidence="4" type="ORF">CYQ11_11970</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51371">
        <property type="protein sequence ID" value="PHQ51371"/>
        <property type="gene ID" value="BLA24_16105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16506">
        <property type="protein sequence ID" value="PPT16506"/>
        <property type="gene ID" value="CYQ11_11970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="370"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="451" mass="46596" checksum="563CA5243A6FF7F1" modified="2018-01-31" version="1">MPLLSALTAPDAGDRPDALTVAGRALSREELLGAAAAVATRVAGASSVAVRAEATPETVVAVVGGLLAGVPVVPLPPDAGPAEREHILRDSGAELLLGEEVPVDIRERASWSGPEPDPGTTAFVLYTSGTTGAPKGALIPRGAVAAGLDGLAEAWRWTAEDTLVHGLPLFHVHGLVLGVLGALRTGCRLVHTGRPTPEAYAAAGGSLYFGVPTVWSRVVRDASAARALAGARLLVSGSAALPAPVFRDLEALTGQRPVERYGMTETLITLSTRADGERRQGSVGLPLPGVRTRVVETGEEGGIGELEVSGPTLFSGYLGRPEATAGAYTADGWFRTGDIAAVEADGTHRIVGRASTDLIKSGGYRIGAGEVENALLDHPAVSEAAVVGVPHEDLGQEIVAYVVADGVGEQALIDFVAGHLSVHKRPRRIRFMDALPRNAMGKPQKKLLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK03</accession>
    <name>A0A2G1XK03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12795</name>
        <name evidence="3" type="ORF">CYQ11_17150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51573">
        <property type="protein sequence ID" value="PHQ51573"/>
        <property type="gene ID" value="BLA24_12795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14365">
        <property type="protein sequence ID" value="PPT14365"/>
        <property type="gene ID" value="CYQ11_17150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="20852" checksum="95C9D2F6A58C0170" modified="2018-01-31" version="1">MALTQDIRKAATDTGYAVAGAADLTAEKIGQFVTDAPELIDQLRKTDPKALGARVTQQAKVVQTQVTTKVTALVGTLDTDVRKIGQTAQDLALQGVGQAVGYAAKAGEAFDKLSERGREAVKTWQGRAAEEITEIAVAVEPDHEQPAAKTGQQNAQAADAKDSKDAKAEADTDKPAAARRGTTATRKPAAKKADAKGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK17</accession>
    <name>A0A2G1XK17_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13520</name>
        <name evidence="4" type="ORF">CYQ11_01240</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51521">
        <property type="protein sequence ID" value="PHQ51521"/>
        <property type="gene ID" value="BLA24_13520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11703">
        <property type="protein sequence ID" value="PPT11703"/>
        <property type="gene ID" value="CYQ11_01240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="294" mass="31368" checksum="69C687323B164EED" modified="2018-01-31" version="1">MELQQMRYVVAVAETGGFTRAAERCHVVQSALSHQIARLEKELGARLFDRTSRSVRLTAAGAAFVPVARQALEAADRARAEVDAVTGEVRGRLAIGAISTVAAVDLAHELGLFRGRYPKVRISLRMDMSEALIEGVRQGTLDVAFIGLVPGTRPRGLHHKELAHDELVAVVAPEHPLAGRRRTDLQRLAGESFVDFPKGSAARQQRAAAFEAAGLVTDSPFEVTDVESLVKLVRANLGVGMVPKAIATTLHGVHALRVRDAPSRVELLVWSTLGPSPAAAAFLSQLGAGAEPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKB3</accession>
    <name>A0A2G1XKB3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ORF">BLA24_13080</name>
        <name evidence="9" type="ORF">CYQ11_17440</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51621">
        <property type="protein sequence ID" value="PHQ51621"/>
        <property type="gene ID" value="BLA24_13080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14414">
        <property type="protein sequence ID" value="PPT14414"/>
        <property type="gene ID" value="CYQ11_17440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="26480" checksum="1B5E0A96ED7D8D18" modified="2018-01-31" version="1">MSDRAPAPATGAPSRTAVVIPAAGRGVRLGPGAPKALRALSGTPMLVHAVRAMAASRAVSLVVVVAPPDGAAEVRTLLDEHPLADLDVTRTDVVVVPGGATRQESVRLGLAALPDDVTAVLVHDAARPLVPVDTVDAVAAAVRDGAPAVVPALPLADTVKQVEPRTGEPEPVVATPERSLLRAVQTPQGFDRRTLVEAHEKVAVEGEGATDDAGLVERLGVQVVVVPGHEEAFKVTRPLDLVLAEAVLARRRANDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKH1</accession>
    <name>A0A2G1XKH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11600</name>
        <name evidence="4" type="ORF">CYQ11_02835</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51727">
        <property type="protein sequence ID" value="PHQ51727"/>
        <property type="gene ID" value="BLA24_11600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11975">
        <property type="protein sequence ID" value="PPT11975"/>
        <property type="gene ID" value="CYQ11_02835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304753" evidence="2">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="28616" checksum="5E4FA930A36BAC7C" modified="2018-01-31" version="1">MTAVLTVACALLSSLANAAGTVLQRKAGRAVPESHAFSARLMGDLLRSPAWLAGMAAEICGAALQGLALSLGSLALVQPIFVSELPFALVIGCLVFHRTLPVAGWAAVVSIAAGLALGLAAAAPSGGHTDVEPGLWALALTVGGGASALCVLGALRHPRGKARAFLFGASAAIAYALTAVLMKAAATTFSLHGAGAFFTSWQTYAFAVAGACSLFLVSNAMESGPIVASQPALTLGDALVSLFFGVLLYEEHLRTGWWLLPEAVGAVLVIGGTLVLPRVGADTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKR1</accession>
    <name>A0A2G1XKR1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">paaF</name>
        <name evidence="5" type="ORF">BLA24_12115</name>
        <name evidence="6" type="ORF">CYQ11_03355</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51817">
        <property type="protein sequence ID" value="PHQ51817"/>
        <property type="gene ID" value="BLA24_12115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12064">
        <property type="protein sequence ID" value="PPT12064"/>
        <property type="gene ID" value="CYQ11_03355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02155">
        <property type="entry name" value="PA_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="94"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="4">
        <location>
            <begin position="336"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="440" mass="48204" checksum="9E2B39E6B852F232" modified="2018-01-31" version="1">MTERGRLLDAAERMSRGELAALQLERLRATLRHVHDNVPFSRAAFEAAGVRPEDCRSLADLARFPFTTKADLRANHPFGMFAVDRSRVRRLHASSGTTGTPTVVGYTRRDLDTWADVVARSIRAAGGRPGDVVHIAYGYGLFTGGLGAHYGAERLGCTVVPASGGMTARQVRLILDLHPRVIMATPSYMLTLLDEFERQGVDPRGTSLRVGVFGAEPWTEEMRREIEERFGIDAVDIYGLSEVIGPGVAQECVETKDGPHIWEDHFYPEVVDPVTGEPLPDGAFGELVLTSLTKEAMPVVRYRTRDLTRLLPGTARVFRRMEKVTGRGDDMIILRGVNLFPSQIEEIVLRTPGVAPHFQLRLTHEGRLDRLTVRAEARPATTAEGRAAAAGEIAGRIRDSVGVSAAVEIVAPGTLERSSGKLRRVVDERGDGGARDQRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKT5</accession>
    <name>A0A2G1XKT5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12225</name>
        <name evidence="4" type="ORF">CYQ11_03465</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51837">
        <property type="protein sequence ID" value="PHQ51837"/>
        <property type="gene ID" value="BLA24_12225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12084">
        <property type="protein sequence ID" value="PPT12084"/>
        <property type="gene ID" value="CYQ11_03465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="420" mass="46448" checksum="9AD74BAE56E92E78" modified="2018-01-31" version="1">MSTVTGSMFGDLLFGAQLKFGRPLMKALMKGDPFIDLLLGVEDPRPIYDAIRAGGPLYQSKGNALVITSHTLGTQVLRDRRLHICHTNGKAPGMELMEKVGWDGSILNLDPPDHTRLRRLAQPAFTPRKIEAYRVGVERVCNELLDKAEARGEFDLIRDYAGPLPLAVIGEMLGVPESEYDRFYRHGRVIGSIIDGVKSLEMAREFKDAHGAYLQLFAELIEARRAEPADDLVSVLVAAHGEDKVTEHELLALCAVLAVTGFETTTNLIGNATLALLEHPEQWEMFRENPELGPKLVEETLRYDSPALQATRIPHEEVEFAGQQIKADQALVVLVGAANHDPEVYRDPDRFDITREGEPEHLSFSGGIHYCIGAPLARMEGDVAMRVLAERMPKLRANGPQRRRSSPVISGVHTFPVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU6</accession>
    <name>A0A2G1XKU6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12180</name>
        <name evidence="6" type="ORF">CYQ11_03420</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51863">
        <property type="protein sequence ID" value="PHQ51863"/>
        <property type="gene ID" value="BLA24_12180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16327">
        <property type="protein sequence ID" value="PPT16327"/>
        <property type="gene ID" value="CYQ11_03420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="853"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="925" mass="99518" checksum="723ACB92A060C8F6" modified="2018-01-31" version="1">MIERENESAALAELRTAAAAGNGRVALLNGSVAAGKTELLVRFTDQAAADGALVLDATGTHTERSWPFALARKLFDSSPLPPEARDEAVRWMDEAAAQTSAEARMRVLPALAGTVLRPAADRLVVVAVDDAHLGDPLSLQFLLCLARRARRARVLIVLTASERLSQDQLGLLAELLRQPNCHRLRLKPLSAEGAGRMLTEYADGPADDGLAAALYERTGGNPLLVRALLEDSAAPATGDAGLPHALRPGEAYAGAVAEILHRCGAEVTALARGTAVLGEAAAPELLGRLLGLAPTAVEGGNRDLTLGGLFHDGRFRDATAAAAVLAGTPEQELAGLHHRAATLLRDDGASTYEVARHLVRTTATEPWAVPVLREAAEYALVDGDLRFARHCLALAQEVCPDGPGRVALKLRLASVLWRSKPAALGDHLTTLVPEMLRERLAPDELVVCVGYLVWAKRTDEAAGVLDTLERSATWSSQEERAALTTARQWLALISPAHRGTPHGTPPEVYAPAEPLGGAADIAHEHAVRAMTAALSHDTPDGAVAEATRVLQRYRLGDGYVMPLVFALWALTYAGKPDLALPWCERLLAECKDRYGPTWQALLTAVRGEIALRQGDLVKAERHASAALSLLPRRDWGGFVALPLSTLILAYTGMGRYDDAMELLNHTGPESELDTLPGLHFRRARGRWYLATGRFQAALGDFLTCGELMDAWGVDVPELAPWRVDASDAWLALGDRKKAVEMAEAQLLRAPDRERGNVLRALGCAETGRDRLERLEEAVQALENGGSRLQLAEVLGELGRGYQAVGDVNRARTLAHKAWHMARFCGAEPLCQGLMPGHAEPEGAPEEPEQEASTPRGTEALSEAEGRVAVLAAHGHTNREIAAMLYVTVSTVEQHLTRIYRKLRVQRRRDLPTTLSSRVGGLRVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU8</accession>
    <name>A0A2G1XKU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11535</name>
        <name evidence="3" type="ORF">CYQ11_02770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51850">
        <property type="protein sequence ID" value="PHQ51850"/>
        <property type="gene ID" value="BLA24_11535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16314">
        <property type="protein sequence ID" value="PPT16314"/>
        <property type="gene ID" value="CYQ11_02770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="199" mass="21725" checksum="2C2A82C80C484CA7" modified="2018-01-31" version="1">MTGDTHLTDSRRRTLLARHGEALDLFTDRVHAVGPAQWGKPTPCTEWTVRDLVNHLAVEQMWVPLLLDGAAVEDVGDALDGDKLGEDPVDTWDRAAADAREAFHARGALQRTVQLSYGASAAHAYCAQMIADLVVHAWDLSRAIGAPERPPNALVEFTRHEVEPYADGLAGSGLFARPVQPPPEADSWERLLAQLGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL30</accession>
    <name>A0A2G1XL30_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10765</name>
        <name evidence="4" type="ORF">CYQ11_00785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51926">
        <property type="protein sequence ID" value="PHQ51926"/>
        <property type="gene ID" value="BLA24_10765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11629">
        <property type="protein sequence ID" value="PPT11629"/>
        <property type="gene ID" value="CYQ11_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="38920" checksum="F66A2BD273884DB6" modified="2018-01-31" version="1">MRSVGVEEEFLLVDPESGAPQAVAETVLAQAEDAHGLEKELQQEQLEVATRPTTTMDELSAEIRARRGAASEQARAAGVAIAALATSPLPVDPSLSAGRRYRRVANEFGLTAQEQLTCGCHVHVGVDSDEEGVAVLDRIRPWLATLTALSANSPFWQGHESGYSSYRSLVWGRWPSAGPVETFGSPERYHAQVTAMLATDTLLDEGMLYFDARLSHRYPTVEVRVADVCLDVADAVLVAALARALVETEARAWRAGEPPSPATVGVLRLASWRAAKSGVQGQLVHPLTWKPKPAEAVCEVLVEHVREALADTGDLAMVQQAMGDLLERGGGAGTQREILAGTGDLRSVVAHAAARTLAPEGDVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLD9</accession>
    <name>A0A2G1XLD9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10905</name>
        <name evidence="3" type="ORF">CYQ11_00645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51949">
        <property type="protein sequence ID" value="PHQ51949"/>
        <property type="gene ID" value="BLA24_10905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11607">
        <property type="protein sequence ID" value="PPT11607"/>
        <property type="gene ID" value="CYQ11_00645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="186" mass="20573" checksum="3F2320503D9BBA09" modified="2018-01-31" version="1">MNMDHVFVCGNPALDFAATLRARRTVRFEMFAAPDRLDAWYVESGMVDSVSPARQADVVRATTVREAVYQLITARRLGVDFDDEALAVVNDAARQAPAAPQLTHSGRWTSATQREALSTVARHAVELLSGQDVPLLKECGNPECTRVYIDRSRGKRRQWCGMESCGNKIKAAAYRARRKTTVTSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLF4</accession>
    <name>A0A2G1XLF4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09855</name>
        <name evidence="4" type="ORF">CYQ11_04235</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52046">
        <property type="protein sequence ID" value="PHQ52046"/>
        <property type="gene ID" value="BLA24_09855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12213">
        <property type="protein sequence ID" value="PPT12213"/>
        <property type="gene ID" value="CYQ11_04235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="22987" checksum="9257FDCD361D65A7" modified="2018-01-31" version="1">MRSTGDGTAVGGPYPLHGGTVEPVPRYSATAAVATQRGRDAGDSSGSDGSRGPDGIGYRGPTACAAAGITYRQLDYWARTGLVEPSVRPAYGSGSQRLYSFRDVVVLKIVKRLLDTGVSLQNIRTAVQHLRTRGMDDLDRMTLMSDGATVYECTSPDEVVDLLQGGQGVFGIAVGVVWRDVESALAQLHGERVDTGETLIGHNPADELARRRNRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM08</accession>
    <name>A0A2G1XM08_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52246">
        <property type="protein sequence ID" value="PHQ52246"/>
        <property type="gene ID" value="BLA24_08775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_MalT" evidence="2">
        <location>
            <begin position="609"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="901" mass="96766" checksum="C35063FDB1589060" modified="2018-01-31" version="1">MTGQQRERRPHGALFEREQEIEAAKRAVDDLGARIAAGEAVSGSLFLYSGEAGAGKTAFLGELRSILAEYGGCTVLQARGSASAETVPFHIVRQLLQPALASMSPERREELLGGWQDIAGPALGIAPPRGTLGDPQGVRDGLDWLVTQIAVNQPPLAVIVDDAHWADAESLAWLASFVTRVTDLPMLTAIAYRDDELEENAPAFLQQVTSGAHRPVVLRPLTPASVAQLVRTSLGPHADDPFCREVWAVTGGNPYETTELIAKAKERGLTPLEESADLLRELGAAARGSGLVTRLERLGSATTRFAWAAAALATEISPRRAALLAGMGPSEGAECADRLRQARILTGTDTLEFVHPLIATAVYQAVPPATRTAMHGLAAWAMTNAGLGAAAASRHLLEVHPDDDQDLVNQLREAAREHLAVGAPEAASRCLERALMEPPSQDDRAAVLFELGCSALLTSPPTTISHLRAALALPEFPKELRVDATYRLSQAYAHNGQLGEAAQVVADQVSATPDGSGRMRLQAAHFLWKGIQLEEEGAQERSRRLAQLVRGLEGRGNAERAMLALRAFDGMIRGEDALEVAEFNDRVLKDGHLPPGLGWTNTEWGFELPSIVGITYVYTDRLDDAEEMFNEAIRSFEISGWRGAHLAFAHEFLGLVHFRRGRLREAESFLREGLRLADRLGPGLPIQWDGTCMLIDTLLAQGRLDEAGEVAERYSFGPPYPPAMVMPDAACVAGRLLLALGRTKEAVAELEAAGRRMEARGRNNTLWAPWALDLAAALAPDEPERARQLADQAVRHAARFGTETAMGEALRRAAHVAGHEGDTLDKLGRAVEHLRKSPCRYEYAAALVDHGVALRRVGRSSEAAGRLKDGLVLAEECGADGLVATARGEIGGMDGAGSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM93</accession>
    <name>A0A2G1XM93_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type III effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07855</name>
        <name evidence="2" type="ORF">CYQ11_00290</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52357">
        <property type="protein sequence ID" value="PHQ52357"/>
        <property type="gene ID" value="BLA24_07855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11559">
        <property type="protein sequence ID" value="PPT11559"/>
        <property type="gene ID" value="CYQ11_00290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="21785" checksum="4C73278F41F69EE6" modified="2018-01-31" version="1">MAPADQPSSPNTDAHSPVSFLAAAAALDAIDDALREARHKTPNAPAPGPEQALASLLLLRQVREQLAGWETGLIETARDAGASWADLAHPLGVASRQAAERRYLRGRPGPVGTTGEQRVQATRQARAADRSTAAWARRNAADLRRLAGQITALTDLPPAARRPLDELHAALAHDDPADLIAPLAAARPHLTAAHPGLTARLDTLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMB8</accession>
    <name>A0A2G1XMB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_07835</name>
        <name evidence="5" type="ORF">CYQ11_00270</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52414">
        <property type="protein sequence ID" value="PHQ52414"/>
        <property type="gene ID" value="BLA24_07835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16258">
        <property type="protein sequence ID" value="PPT16258"/>
        <property type="gene ID" value="CYQ11_00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="85"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="425" mass="45455" checksum="3FC4F2EC88B7F7C3" modified="2018-01-31" version="1">MTFFSVPSTFSAPALPEPSAALAPAPVRRVLASPRRVLLGGALAGALFLTGALPAGAAAAAPAPTPAHAGQQAAPKLDIQALRAAVAKLDDPQATAAQIRVSGSSGRWYGTAGVADLRTGRKVTADDKFRVGSITKVFVATVVLQLSAQGRVDLDAPVQRYLPGVLPAEYPPIAVGQLLNHTSGLPDESGPGLPDTSTPEKVLQHRYDQWTPQQMVAAVSHGPMKFAPGTRQEYRGINYVLAALLIEKVTSQSYGAEIDKRILRPLGLHDTSLPGNDPRIHGPHVHGYLALADGTLSDATVFNQSEAWGEGEMISTSRDLERFMTALFSGDLLPRDTLDKMFTLPSGDVRMVDGSPARYSMGLQTASVNGMTLWGKTGERYGYNSGMFSTRDQQRRVVYSFNPTHRDQTQTRMTLRIADAVTRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMD3</accession>
    <name>A0A2G1XMD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07685</name>
        <name evidence="2" type="ORF">CYQ11_00115</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52331">
        <property type="protein sequence ID" value="PHQ52331"/>
        <property type="gene ID" value="BLA24_07685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11535">
        <property type="protein sequence ID" value="PPT11535"/>
        <property type="gene ID" value="CYQ11_00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="10233" checksum="058DB61067A8E4A7" modified="2018-01-31" version="1">MPLVSSTGMRPLLYYSTIDIGTITFPQRTDGDDVVVIPGDGLRLSSHDPSDYPMVRLEHLSQAPQSTPAGNWDYQRTFTGVTVPNKRVSWGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMD5</accession>
    <name>A0A2G1XMD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000090">
        <property type="protein sequence ID" value="PHQ52299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52299">
        <property type="protein sequence ID" value="PHQ52299"/>
        <property type="gene ID" value="BLA24_08365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015066">
        <property type="term" value="F:alpha-amylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036379">
        <property type="entry name" value="A-amylase_inhib_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="80" mass="8324" checksum="70B3FD2CB397C925" modified="2018-01-31" version="1">MAATPAPSGTTSAAPFVGCASLTSNANGRAQVKNICSHTINATVSVDWAWDPDCQSIGAGRSATIRWDSTKGRAEYAYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMM3</accession>
    <name>A0A2G1XMM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Universal stress protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_06930</name>
        <name evidence="5" type="ORF">CYQ11_27080</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52505">
        <property type="protein sequence ID" value="PHQ52505"/>
        <property type="gene ID" value="BLA24_06930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16040">
        <property type="protein sequence ID" value="PPT16040"/>
        <property type="gene ID" value="CYQ11_27080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="17811" checksum="7925214F2316EBFC" modified="2018-01-31" version="1">MNEDSAHDAHQGKRDDGHSLPAGFERGTDGPRVIVAGVDGSDTSWRAAAYAAGLARRQNALLALVYVQPVLAGGAALGAPVADMTEEVAEELLAEIRATTERLRGVHEVRWEFHTFRGDPYTGLVRAADELKADAVVVGASEQAGHRIIGSVAVRLVKAGRWPVTVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMM9</accession>
    <name>A0A2G1XMM9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Geranylgeranyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06675</name>
        <name evidence="4" type="ORF">CYQ11_26825</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52463">
        <property type="protein sequence ID" value="PHQ52463"/>
        <property type="gene ID" value="BLA24_06675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15995">
        <property type="protein sequence ID" value="PPT15995"/>
        <property type="gene ID" value="CYQ11_26825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="360" mass="38276" checksum="76A7995DB8BE5C92" modified="2018-01-31" version="1">MTILETATPHIDLGRVRQAVEDTLECFLAGKAEGEDGARIAAPLRVLRDFLGGGGKRVRPLYCCLGWFAVAGRPPTTEVLRAAAGLELFHTFALIHDDVIDGSDSRHARPTAHRAFEQDGPGPRARWFGESAAILLGDLCEVWSAELLGGLSGPSPASARAVLDRMRGELVIGQFLDLRAFGTDFGNVEDALAVIHYKTTKYTVERPLQIGAAMAGASSSVLGVCAAYARPMGEAFQMCDDLEDVLPDPARGDATGNDLREGKHTVVLALALRDAGAAESARLRELVGDPDLDADGLAEAQALIAATGAPRTVRRMVVERRRQALDVLAAAPFGPAARQALARLTDLALPGVDRWEEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMQ1</accession>
    <name>A0A2G1XMQ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06800</name>
        <name evidence="3" type="ORF">CYQ11_26950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52483">
        <property type="protein sequence ID" value="PHQ52483"/>
        <property type="gene ID" value="BLA24_06800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16016">
        <property type="protein sequence ID" value="PPT16016"/>
        <property type="gene ID" value="CYQ11_26950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="403" mass="43426" checksum="6E471EACE4D0E5B8" modified="2018-01-31" version="1">MFDVIYLVFSAVSWVIVGYKARAWFRDRGNTDLGVTTLMTAGVPVVFLFSAPSVYRAFDRLTGVANLAMVFLYSAVVLFAAGATILLLRWTGGKDEAARARAAVRSRWAVAAVTVAWAAAVVCFAVGRPDAVEHPRDFSTAYADAPGVVAFLVLYLAIFGTSLAGLGCLCPRYAAQLGRSWLAKGLRTLAAGCWLGLVYCACKLAGFALSWAGHEAYWLSNGVAPLTASVAALLVLLGFSLPAVGPRAAAWRRLRRLEPLWREVTAHAPEVTIGESGWITRWPFADLEWRANRRMAEIRDIQRGVRRHVEPVALDIAREKAAAAALDAHGLAAVVEAAALRRGLANQATGHVPSPHADSVVMTVSADPAEEHEHLARVADVFHDPLVDAVLTELREISAARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMQ2</accession>
    <name>A0A2G1XMQ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hercynine oxygenase</fullName>
            <ecNumber evidence="1">1.14.99.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtB</name>
        <name evidence="5" type="ORF">BLA24_06945</name>
        <name evidence="6" type="ORF">CYQ11_27095</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O</text>
            <dbReference type="Rhea" id="RHEA:42672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="EC" id="1.14.99.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EgtB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.50" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52508">
        <property type="protein sequence ID" value="PHQ52508"/>
        <property type="gene ID" value="BLA24_06945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16043">
        <property type="protein sequence ID" value="PPT16043"/>
        <property type="gene ID" value="CYQ11_27095"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044875">
        <property type="term" value="F:gamma-glutamyl hercynylcysteine sulfoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02035">
        <property type="entry name" value="EgtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032890">
        <property type="entry name" value="EgtB_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="4">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="179"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gamma-glutamylcysteine binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="442" mass="49148" checksum="FE321D1792934D62" modified="2018-01-31" version="1">MTASRVDPGTLRSRAASALLAARDRTRALTGCVDDRELVAQHSPLMSPLVWDLAHIGNQEELWLLRAVAGQEALLPGIDSVYDAFEHPRAERPSLPLLSPAQAHGYVADVRGRVLDVLDATPVEGGGPLVESSFAFGMIAQHEQQHDETMLITHQLRAGPAALTAPQPPPAAVDAALLPREVLVEGGPFTMGTSTEPWALDNERPAHRREVAPFFIDTLPVSNDAYARFIEDGGYDDPRWWHQEGWEQVRRHGITAPLFWRREGGGWLRRRFGVVEEVPPAEPVLHVSWYEAAAYAAWAGRRLPTEAEWEKAARHDPASGRSRRHPWGDEDPSPEHANLGQRHLRPAPVGAYAAGASPLGVRQLIGDVWEWTASDFLPYPGFRAFPYREYSEVFFGDRYKVLRGGSFAVDPVACRGTFRNWDLPVRRQIFSGFRTARDAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR4</accession>
    <name>A0A2G1XMR4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52500">
        <property type="protein sequence ID" value="PHQ52500"/>
        <property type="gene ID" value="BLA24_06900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="268" mass="27833" checksum="1DC78DCAB12E66CC" modified="2018-01-31" version="1">MAALLGLRTPPVRVRHLSPVRRTWAAVLGLRVETEAGRRAAPAASRRPARGRHPSHREGGVVVVGAFTSRTRRGWGVVSAVLGVLVTSVVVGLGIVMETGGERRQAPAPSAPTGAPFPPTAVASPASPPRAGVRWSGWVFLPPSAASEAEASGIDLDREPPEPRGASQGDDLWAADSASERVVFDAGGFAEGVNVPVRDLTPSMCRAVMLTGRREAPKAVIVEPGSVACFVTTEGRVAAFEVARSEGGRGLSLSVVVWSESPSTDSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX2</accession>
    <name>A0A2G1XMX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">(4Fe-4S)-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Lactate utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_07300</name>
        <name evidence="11" type="ORF">CYQ11_27455</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52566">
        <property type="protein sequence ID" value="PHQ52566"/>
        <property type="gene ID" value="BLA24_07300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16104">
        <property type="protein sequence ID" value="PPT16104"/>
        <property type="gene ID" value="CYQ11_27455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="LUD_dom" evidence="7">
        <location>
            <begin position="73"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="315"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3390" evidence="8">
        <location>
            <begin position="409"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="489" mass="53505" checksum="11DE75FA1697A557" modified="2018-01-31" version="1">MSRTYLGMPAFPVAAAGSTRDATLRANLRRATHTIRAKRAAAVAETADWDRLRAAGAAVKDRTLRHLDHYLVRLEENVTRAGGTVHWAADAEEANRIVTGLVQATGQREVVKVKSMATQETGLNAALERAGVRAYETDLAELIVQLGDDLPSHILVPAIHRSRTEIRDVFRDRMADWGRPAPEGLTDRPADLAEAARLHLREKFLTARVAVSGANFMVAETGTMVVVESEGNGRMCLTLPRTLISVVGIEKVVPTWRDLEIYLQLLPRSSTAERMNPYTSMWTGTTDQDGPDEFHLVLLDNGRTDTLADTVGRQALRCIRCSACLNVCPVYERAGGHAYGSPYPGPIGAILTPQLRGLASPLEKSLPYASSLCGACYDVCPVAIDIPEVLVHLRERVAQGGEVTVRGVRTVVKPARRHALEHAAVRAAGWTLGHPAALRRAQRLAARARRLRPRRLPGPGRAWTDSRDLPEVPAESFRDWWARTRGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX6</accession>
    <name>A0A2G1XMX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07500</name>
        <name evidence="3" type="ORF">CYQ11_27650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52605">
        <property type="protein sequence ID" value="PHQ52605"/>
        <property type="gene ID" value="BLA24_07500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16142">
        <property type="protein sequence ID" value="PPT16142"/>
        <property type="gene ID" value="CYQ11_27650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="26604" checksum="7103456DDC9F0216" modified="2018-01-31" version="1">MGTTQLESVPEPKYWHLKTVLSDALDSEFAVGEILPNERELAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRMGVAVADAEHAWPGTAADAWQPVDSTEEAPPAALARLLGTEPGQVVHVVRRARKTRGQPVAAELLYVPADSVPGLAPLDAPAGPSRARAVLRELQQLRLEGQERAVELGSARADDAKQLDRLPGAPVLLVTTRYFADGRTAAVAVATYRADTCRLTFGESDGAGVRLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNM4</accession>
    <name>A0A2G1XNM4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_04515</name>
        <name evidence="16" type="ORF">CYQ11_01775</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52842">
        <property type="protein sequence ID" value="PHQ52842"/>
        <property type="gene ID" value="BLA24_04515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11791">
        <property type="protein sequence ID" value="PPT11791"/>
        <property type="gene ID" value="CYQ11_01775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="391"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="483"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="575"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="879"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1311"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="800"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ52842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT11791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1431" mass="152547" checksum="60AE1982B419A0AD" modified="2018-01-31" version="1">MAGTTVDGSKPASRRRAGAGGGKAGEPELRRLLAGLTAVRDGDFGTRLPDDADGLLGEIALVFNGMVDQLALFTSEVTRVAREVGTEGTLGGQAEVPGVSGTWADLTDSVNAMAGNLTSQVRDIAQVATAVARGDLSQKIDVDAHGEILELKETVNTMVDQLSSFAAEVTRVAREVGSEGRLGGQAEVPGVGGVWRDLTDSVNFMAGNLTAQVRNIAQVTTAVARGDLSQKITVTARGEILDLKETINTMVDQLSAFADEVTRMAREVGTEGRLGGQADVKGVLGTWRDLTDSVNSMAGNLTAQVRSIAQVATAVARGDLSQKITVTARGEILDLKETINTMVDQLSAFADEVTRVAREVGTEGKLGGQATVRGVSGTWKDLTDNVNVMASNLTGQVRSIAQVATAVARGDLSQKITVEAKGEIAALTAVINTMVDTLSAFADEVTRVAREVGTEGMLGGQARVPNVAGTWKDLTDNVNSMANNLTGQVRNIAQVTTAVANGDLSKKIDVAARGEILELKTTINTMVDQLSSFAAEVTRVAREVGSEGRLGGQAEVEGVSGTWKRLTENVNELAGNLTRQVRAIAEVASAVAEGDLTRSITVNASGEVAELKDNINAMVESLRETTRANQEQDWLKSNLARISGLMQGHRDLALVAELVMDELTPLVSAQYGAFYLAEETAGGTELALVGSYGYPDDPARPTRIPLGRSLVGQAARNRRTIAVDDLPGGYVTISSGLGHTTPASLIVLPIVAEEQVLGVIELASVTRFTQVHRDFLDQLMETIGVNVNTIVANARTDELLEESQRLAGELQARSEQLQVQREELQRSNQELEEKAALLASQNRDIEAKNLQIEQGRQELEDRAQQLALASKYKSEFLANMSHELRTPLNSLLILAQLLEQNTTRNLTPKQVEYAGIIHSAGSDLLQLINDILDLSKVEAGKMDINPERVSLRHLLDYVETTFRPMTTQKSLDFTISTAPGIPDELLTDDSRLRQVLSNLLSNAVKFTERGAVELRIEAASDKEVPESVLPGGTIVAFRVKDTGIGIAEQQLETIFGAFQQADGTTNRAYGGTGLGLSISREIAYLLGGAVTAQSTPGKGSTFTLYLPVARADFEEPAGTPPAEAALPGKDRNASHAGGPPVPLPRQKRRLMVIEERPRGLLSLVAESAVADLVGSPESPPQEVPEVVTVAGAREAAAALAAQPCHCVVLELDMPDGEALRFLEAMDGDSALTQVPVLAHNSRRLPTAHERTLRARADASPLELLSSLDELRERIALHLTAEQPGDVLPLACAGQHDRTAPQPADDSLAGRTVLVVDDDARNLYALSGILELQGIQVLHAENGRKGIETLTAHPDIDLVLMDVMMPEMDGYAATAEIRRMPAYARLPIVAVTAKAMPGDREKSLASGASDYVTKPVDSADLIACVRRWLNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR5</accession>
    <name>A0A2G1XNR5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_04775</name>
        <name evidence="7" type="ORF">CYQ11_28760</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52882">
        <property type="protein sequence ID" value="PHQ52882"/>
        <property type="gene ID" value="BLA24_04775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11459">
        <property type="protein sequence ID" value="PPT11459"/>
        <property type="gene ID" value="CYQ11_28760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="26237" checksum="D6C2E8A667CF1C66" modified="2018-01-31" version="1">MTTYVYGITRAGHTGLPRDLTGIGDPPLPVRLVTQGSLAAVVSDCPEELRPKRRDLLAHQHVLAEAGREDPVLPMRFGSVSDGDEKVRQVLDEHAGRYEEQLGRLAGRVEYNIKAVHREDVVLHLVLAENAGLRTLAEANRADGGGSYEERLRFGEMVAEGVRERELRDAALVREALVPLAEDDRPGPESAGWFVNLSFLVDRSDTGRLLAEVGRLGKENPQLDLKVYGPLPPYSFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNT4</accession>
    <name>A0A2G1XNT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05005</name>
        <name evidence="3" type="ORF">CYQ11_28525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52915">
        <property type="protein sequence ID" value="PHQ52915"/>
        <property type="gene ID" value="BLA24_05005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11424">
        <property type="protein sequence ID" value="PPT11424"/>
        <property type="gene ID" value="CYQ11_28525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="270" mass="28203" checksum="B9D8372AC3CFEFC4" modified="2018-01-31" version="1">MRSVPIGGVRVRRGSRVRLRPVGRADVLDPSLTGRVAEVTELTEDLEGRVQLVVSLDGDAGRDFATGLGHRFFFSPEEVEPVVGETAPPTARVLIAGIGNVFLADDAFGPEVVAALRRRPVAAGVHVADFGIRGMDLAHRLLDGYDVAVFVDAAPRGGAPGTLYLIEPAPVDAAAPAPPDAHGMDPVRVLALAHRLSAAGQGGAVPRVVVLGCEPLVRLRGDEPEVAFGLSEPVRAAVPEAVRWLESLTRALQGDPRAPLDAVPLAPVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP03</accession>
    <name>A0A2G1XP03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04500</name>
        <name evidence="2" type="ORF">CYQ11_01760</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52964">
        <property type="protein sequence ID" value="PHQ52964"/>
        <property type="gene ID" value="BLA24_04500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16290">
        <property type="protein sequence ID" value="PPT16290"/>
        <property type="gene ID" value="CYQ11_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="142" mass="14565" checksum="F3A937D2CAE5BCCA" modified="2018-01-31" version="1">MMLLSQARGLKVITVGEAAEVGTVEALTIDASTAGVSHVRLSGRTAGGHDVLPWSTIHAVGPDAVMVRSLPAAETADAAAPPHREALGSRVLTELGDDHGTVEDIAFDPTTGRVRTVHTTLGAVPGQRLLGLGDYALVISAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP72</accession>
    <name>A0A2G1XP72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04225</name>
        <name evidence="3" type="ORF">CYQ11_14035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53032">
        <property type="protein sequence ID" value="PHQ53032"/>
        <property type="gene ID" value="BLA24_04225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13861">
        <property type="protein sequence ID" value="PPT13861"/>
        <property type="gene ID" value="CYQ11_14035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="76" mass="8087" checksum="E7ADD582A7BBF24C" modified="2018-01-31" version="1">MPEGCAEGFAEGFADGEAAAAGMCAAVASRSYNCCARSSSLTPAWYDTTRSKSTDRWRVPSGVSSFQRQPTRRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT2</accession>
    <name>A0A2G1XPT2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">BLA24_02720</name>
        <name evidence="5" type="ORF">CYQ11_05015</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53244">
        <property type="protein sequence ID" value="PHQ53244"/>
        <property type="gene ID" value="BLA24_02720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12337">
        <property type="protein sequence ID" value="PPT12337"/>
        <property type="gene ID" value="CYQ11_05015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="40952" checksum="A83EA4B42E2C8C14" modified="2018-01-31" version="1">MTTSTRGAAKAPAVLVLEDGRTFRGRAYGAVGATFGEAVFSTGMTGYQETLTDPSYHRQVVVMTAPHVGNTGVNDEDPESGRIWVAGYVVRDPARVPSNWRSRRSLDEELARQGVVGISGIDTRALTRHLRERGAMRVGIFSGETLPDAAAMLDEVRRAPEMKGADLAAEVATKEAYVVPAIGEKRFTVAAIDLGIKGMTPHRMAERGVEVHVLPATATVEDVYAVDPDGVFFSNGPGDPATAEHPVAVMREVLSRKTPLFGICFGNQILGRALGFGTYKLKYGHRGINQPVQDRTTGKVEVTAHNHGFAVDAPLDKATDTPYGRVEVSHVCLNDDVVEGLQLLDQPAFSVQYHPEAAAGPHDAAYLFDRFVSLMEGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPW1</accession>
    <name>A0A2G1XPW1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G-like protein EF-G2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02940</name>
        <name evidence="6" type="ORF">CYQ11_05240</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53285">
        <property type="protein sequence ID" value="PHQ53285"/>
        <property type="gene ID" value="BLA24_02940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12381">
        <property type="protein sequence ID" value="PPT12381"/>
        <property type="gene ID" value="CYQ11_05240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="735" mass="78231" checksum="546671AADF166128" modified="2018-01-31" version="1">MGEKTTTHPGAAGRAVTADRPGDIRNVVLVGHSGSGKTTLIEALALATGAVNRAGRVEDGASVSDYDEIEHRQQRSVQLSLVPVEWAGIKINLLDTPGYADFVGELRAGLRGADAALFVVSAAEGTEGITGATRMVWEECAAVGMPRAIVVTHLEAARADFDEMTETCRTAFGGDSPDSVLPLYLPLHGAEGADGHRPVAGLIGLLTQRVFDYSSGTRTEREPDPEQLPRIEEARNALIEGIIAESEDETLMDRYLGGEDIDVKTLIEDLERAVARGSFHPVLAAAPAAEGARQGLGTVELLELVTGGFPTPYDHPAPAVTTPDGAARPALACDPAGPLAAEVIKTASDPYVGRISLVRVFSGTLRPDETVHVSGHGLEDRGHESHDVDERIGALSSPFGKHQRQLAQAIAGDIACVAKLTRAETGDTLSDRSDPLLMEPWLMPDPLLPVAIQAHSKADEDKLSQGLARLVAEDPTMRLEQNPQTHQVVLWCLGEAHRDVALERLRTRYGVQVDIVPHKVSLRETFASRAGGRGRHVKQSGGHGQYAICEIEVEPLPGGSGIEFVDKVVGGAVPRQFIPSVEKGVRAQAARGVAAGYPLVDVRVTLLDGKAHSVDSSDAAFQTAGALALREAAAEARIHLLEPVADVRVLVPDDYVGPVMSDLSGRRGRVVGTEQSGAGRTLVRAEVPEIEIGRYAVDLRSLSHGTGRFSRSYARHEPMPPQLADRIREQAENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ32</accession>
    <name>A0A2G1XQ32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03120</name>
        <name evidence="3" type="ORF">CYQ11_05420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53344">
        <property type="protein sequence ID" value="PHQ53344"/>
        <property type="gene ID" value="BLA24_03120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16362">
        <property type="protein sequence ID" value="PPT16362"/>
        <property type="gene ID" value="CYQ11_05420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="135" mass="14415" checksum="1AAA24E4D08F83B6" modified="2018-01-31" version="1">MKREEGSGLDLGQGPGRLLVWLYGVFTVAAASRSVVQMLMDFGRAPLAYVLSAAAAVVYAFITYSLVRGGPAARRAALVCCAAELAGVLTVGTWTLLEPSAFPDATVWSDYGMGYLFIPVILPVTAMVWLRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ42</accession>
    <name>A0A2G1XQ42_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02175</name>
        <name evidence="2" type="ORF">CYQ11_04540</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53330">
        <property type="protein sequence ID" value="PHQ53330"/>
        <property type="gene ID" value="BLA24_02175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16348">
        <property type="protein sequence ID" value="PPT16348"/>
        <property type="gene ID" value="CYQ11_04540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="113" mass="11924" checksum="E60D81499B02CEEE" modified="2018-01-31" version="1">MTDSPAARGARAAARRLAAAHGPRLEADVEAALHARGPAQYADPASLGSLIVSAAALAWTVYQDLRARTERPARAVVTRRVRLELPADGRTSGDERDGIIAVVVDEVVTDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQA1</accession>
    <name>A0A2G1XQA1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="13" type="ORF">BLA24_03175</name>
        <name evidence="14" type="ORF">CYQ11_05475</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53319">
        <property type="protein sequence ID" value="PHQ53319"/>
        <property type="gene ID" value="BLA24_03175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12416">
        <property type="protein sequence ID" value="PPT12416"/>
        <property type="gene ID" value="CYQ11_05475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="11">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="12">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="180" mass="19011" checksum="5EA801150875CC62" modified="2018-01-31" version="1">MTEAQETEPVHGGPAVPQTRTARHRRIVDILNRQAVRSQSQLAKLLADDGLTVTQATLSRDLDELGAVKIRNTGGELIYAVPSEGGDRTPRAPLGESASEARMGRLAAELLISAEASANLVVLRTPPGAAQFFASAIDQAGVHEIIGTIAGDDTLLLISRDPAGGQALADHLLRLAQKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQH3</accession>
    <name>A0A2G1XQH3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 17" type="primary">hisD</name>
        <name evidence="17" type="ORF">BLA24_00635</name>
        <name evidence="18" type="ORF">CYQ11_07645</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53472">
        <property type="protein sequence ID" value="PHQ53472"/>
        <property type="gene ID" value="BLA24_00635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12777">
        <property type="protein sequence ID" value="PPT12777"/>
        <property type="gene ID" value="CYQ11_07645"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ53472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="441" mass="46385" checksum="FAE48A3F20C06C55" modified="2018-01-31" version="1">MISRIDLRGDATLDGGIDRDLLPRAELDVEAALEKVRPICDDVHHRGTAALIDYAERFDGVRIERVRVPAEAIARALEELDPAVRAALEESIRRARLVHRAQRRTDKTVTVVPGGTVTERWVPVDRVGLYVPGGRAVYPSSVVMNVVPAQEAGVPSLAVSSPPQKEFGGLPHPTILAACALLGVEEVYAAGGAQAVAMFAYGTDECRPVRLVTGPGNIWVAAAKRLLKGRIGIDAEAGPTEIAILADATADPVHVAADMISQAEHDPLAAAVLVTDSPELADATEAELKAQVALAKHAEERITPALAGRQSAIVLVDDIDAGLKVVDAYGAEHLEIQTAGAEAVAARVRNAGAVFVGPYAPVSLGDYCAGSNHVLPTGGCACHSSGLSVQSFLRGIHVVHYTRDALAEVTHHVVNLAEAEDLPAHGAALKARFGWKVPQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ6</accession>
    <name>A0A2G1XQJ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000013">
        <property type="protein sequence ID" value="PHQ53419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53419">
        <property type="protein sequence ID" value="PHQ53419"/>
        <property type="gene ID" value="BLA24_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="138" mass="14530" checksum="9C024A5534FF4E22" modified="2018-01-31" version="1">MTSGCTGALVDQDSLYVAGQGLTYAYDLTGGKERWTYKGDANRSTAPVAVHDGGSPSTLPPPSDRPGRLAYVATSSGKALRTVDHSNDARDRKNEAVMGRIAGFPRLVDERLLLIKDGGLADENEGVILAISAPEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ8</accession>
    <name>A0A2G1XQJ8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ORF">BLA24_00750</name>
        <name evidence="18" type="ORF">CYQ11_07760</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53493">
        <property type="protein sequence ID" value="PHQ53493"/>
        <property type="gene ID" value="BLA24_00750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12798">
        <property type="protein sequence ID" value="PPT12798"/>
        <property type="gene ID" value="CYQ11_07760"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="123"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="334"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ53493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT12798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="484" mass="50319" checksum="2A10E1FA17DC768E" modified="2018-01-31" version="1">MVGHQVSPAEFHGKHITVAGLGVSGVSAARALAGLGARVTVVDGGDGPALRERARVLTDQGVAVRLGDADTLPEGTDLVVTSPGWKPESPLFAAAAEAGVDVVGDVEIAWRLRGEDAAPWLAVTGTNGKTTTVQMLASILEAAGLRTAAVGNIGTPIIDVVLGDQPHDVLAVELSSYQLHWAPSLRAHSAAVLNVAPDHLDWHGSMRAYAADKGRIYEGNTVACVYNVEDPRTEHLVREADVEEGCRAIGFTLGAPGPSMLGVVEGLLVDRAFVENRQQQAQELAEVADIAPSAGPAAPHNIANALAAAALARAFGVPPEAVRDGLRAFRPDAHRIAHVAEVDDVVYVDDSKATNPHAAQASLATYESIVWIAGGLAKGATFDELVTASAKRLRGVVLIGADRALIREALARHAPDVPVVDLDRTDTGAMAAAVREAARLAGPGDTVLMAPACASMDMFTNYNKRGEAFAEAVRALETGRGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQM8</accession>
    <name>A0A2G1XQM8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_01050</name>
        <name evidence="11" type="ORF">CYQ11_08060</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53548">
        <property type="protein sequence ID" value="PHQ53548"/>
        <property type="gene ID" value="BLA24_01050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12853">
        <property type="protein sequence ID" value="PPT12853"/>
        <property type="gene ID" value="CYQ11_08060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="206" mass="22708" checksum="6CDCFC3EDCAEF788" modified="2018-01-31" version="1">MSVVATATATDTGHAHPSVNRPNLTSVGTIIWLSSELMFFAALFAMYFTLRSVMGTDHWKEMASALNLPFSATNTTILVLSSLTCQLGVFAAERGDVKKLRMWFVVTFVMGAIFIGGQVFEYTDLVKEEGLSLSSDPYGSVFYLTTGFHGLHVTGGLIAFLLVLGRTYAAKRFTHHQATAAIVVSYYWHFVDVVWIGLFATIYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQQ7</accession>
    <name>A0A2G1XQQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000011">
        <property type="protein sequence ID" value="PHQ53574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53574">
        <property type="protein sequence ID" value="PHQ53574"/>
        <property type="gene ID" value="BLA24_00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="306" mass="33834" checksum="B0B3CFB0F770966E" modified="2018-01-31" version="1" fragment="single">ATTFALEGIVELSSQMADENRNDIRIEAALAKLYASEMGWLISDELVQIRGGRGYESAASLAARGERAVPAEQMLRDSRINRIFEGSTEIMHLLIAREAVDAHLSVAGDLIDPDKSLGDKARAGARAGGFYARWLPKLVAGPGQLPRTYSEFHPAGHRDLSGHLRYVERSSRKLARSTFYAMSRWQGRMETKQGFLGRIVDIGAELFAMSAACVRAEHLRVRGEHGSEAYELANAFCRQSRIRVEELFRRLWTNTDDLDRKVVSGVMAGSFEWLEAGVIDPSGDGPWIADATPGPAKAENVHRPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQQ8</accession>
    <name>A0A2G1XQQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000009">
        <property type="protein sequence ID" value="PHQ53577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53577">
        <property type="protein sequence ID" value="PHQ53577"/>
        <property type="gene ID" value="BLA24_00215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="99" mass="11348" checksum="08B789E9DAD3B283" modified="2018-01-31" version="1" fragment="single">MVPPRRTSAGTWSIVAHGSTRTTSPAPREDVQRQQDPREEDAQQPAERVDPGAVEQPEGAQRHQIAQPEAHHDAQQDRQQEDQPQQRIRRQREFEGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQR7</accession>
    <name>A0A2G1XQR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_00150</name>
        <name evidence="5" type="ORF">BLA24_00165</name>
        <name evidence="4" type="ORF">BLA24_20195</name>
        <name evidence="7" type="ORF">CYQ11_10595</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000007">
        <property type="protein sequence ID" value="PHQ53584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000007">
        <property type="protein sequence ID" value="PHQ53587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49945">
        <property type="protein sequence ID" value="PHQ49945"/>
        <property type="gene ID" value="BLA24_20195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53584">
        <property type="protein sequence ID" value="PHQ53584"/>
        <property type="gene ID" value="BLA24_00165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53587">
        <property type="protein sequence ID" value="PHQ53587"/>
        <property type="gene ID" value="BLA24_00150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13278">
        <property type="protein sequence ID" value="PPT13278"/>
        <property type="gene ID" value="CYQ11_10595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014078312" evidence="2">
        <location>
            <begin position="22"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="32294" checksum="52980FE3987CE6F8" modified="2018-01-31" version="1">MLDLSRLRALHAVSVHGSVSAAAVALGYTPSAVSQAITKLERETRTTLLERRGRGVALTDAATRLAETAGQLLTLVERAETDLEEQRGLPTGRLLVGAFASAARGLLPGVLAALRREHPALDARLSEVDPHLSVDLVAQGVLDLAVTFEWDTIPLPAPGGLRRARIGDDLCDVLVPEGHPLAGRERLAHHDLAHQRWVGQPPGTVCHGWLVGALRAAGSEPDLAYQAAENHTQVALVAAGLGIALLPRLGRGPLPEGVRAVPLDPVPVRRLFAYWRTGTARRPAVTETVRLLHEQWPDRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQX1</accession>
    <name>A0A2G1XQX1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53559">
        <property type="protein sequence ID" value="PHQ53559"/>
        <property type="gene ID" value="BLA24_01110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="76" mass="8113" checksum="3424BF5A71C61396" modified="2018-01-31" version="1" fragment="single">PAGPAARLDALTVREREVLVHVAGGLSNDEIGERLAVSPLTVKTHVNRTMAKLGARDRAQLVVAAYESGLVRPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9A3</accession>
    <name>A0A2G1X9A3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_30295</name>
        <name evidence="9" type="ORF">CYQ11_23390</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47805">
        <property type="protein sequence ID" value="PHQ47805"/>
        <property type="gene ID" value="BLA24_30295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15430">
        <property type="protein sequence ID" value="PPT15430"/>
        <property type="gene ID" value="CYQ11_23390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305469" evidence="5">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="69"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="7">
        <location>
            <begin position="69"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ47805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="306" mass="32268" checksum="12562F3387C69C61" modified="2018-01-31" version="1">MKLRNTAAAAAVVLALTATATACGKSGSPDDKSDKADGNSSAPAAPTYQVNTSADVQGSPVFEKIKGKKITIGTKADQPGLGFENPGNKKRSGFDVEIARMIAADLGFDEAHIEFKTVPSEARETQIASGGVDLYVGTYTINDERKKQVGFGGPYYIAGQSLLVKADSDIKGPDDLKGKKVCSATGSTPLKRIKEEKYGVAEAKAQQGYQLCVQDLVNGTVDAVTTDDAILKGYAAENKGALKVVDNTFSKEPYGVGLRKDDAALREAVNKAIEAHEKNGDWKKAYDATLGRSGSTAPTPPAIERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9G9</accession>
    <name>A0A2G1X9G9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K(+)-transporting ATPase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdpF</name>
        <name evidence="2" type="ORF">BLA24_30690</name>
        <name evidence="3" type="ORF">CYQ11_23785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47877">
        <property type="protein sequence ID" value="PHQ47877"/>
        <property type="gene ID" value="BLA24_30690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15502">
        <property type="protein sequence ID" value="PPT15502"/>
        <property type="gene ID" value="CYQ11_23785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="29" mass="3119" checksum="23D68FCAF1EE8B8E" modified="2018-01-31" version="1">MTAENVVGLVVAVALLGYLILALVFPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9H7</accession>
    <name>A0A2G1X9H7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30315</name>
        <name evidence="3" type="ORF">CYQ11_23410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47809">
        <property type="protein sequence ID" value="PHQ47809"/>
        <property type="gene ID" value="BLA24_30315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15434">
        <property type="protein sequence ID" value="PPT15434"/>
        <property type="gene ID" value="CYQ11_23410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="332" mass="36266" checksum="965B6CAF07D46823" modified="2018-01-31" version="1">MAPRLPHPGRRRAVQTGAVAAAVFALLLWWLLPPGEKPKPSGRLWFSTGVPTGVYAKYGDLLKEDLAQDLPSLDVQLTRSQGGMDNLRQLTAGKADFTLATADAVATYQQEHRTGADRLRACARLYDDYMQLVVPRDSAVRSARDLKGLRVGVGADASGVQLITRRLLEAAGLRFDSDIEPVRVGIDRMPGLLEKGRLDAFFWSGGLPTNAVQSLGRRLPIRLVQLGDLIGPLHALGPQTRFYRAATMPADAYPEQRSGQVVKTIAVANLLVTLESTDAGLTESVTRTVIRSRDRIGTKVHAAQKVDLRTAIFTNPLTLHEGARRYYVSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Q1</accession>
    <name>A0A2G1X9Q1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31380</name>
        <name evidence="3" type="ORF">CYQ11_24420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47967">
        <property type="protein sequence ID" value="PHQ47967"/>
        <property type="gene ID" value="BLA24_31380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15591">
        <property type="protein sequence ID" value="PPT15591"/>
        <property type="gene ID" value="CYQ11_24420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="11084" checksum="E25EBFDBC5288C30" modified="2018-01-31" version="1">MDNAISFEELDNVAGEVLPERTVMGIVATPLSYAGPGDPVGGSGAGAGSSSSSAATGGGVGGVFAPPADHHGTTMLAACQAVDRQGTPGLLGSLGLPSTNPTTSMTCMPTAISSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9T0</accession>
    <name>A0A2G1X9T0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">acnA</name>
        <name evidence="13" type="ORF">BLA24_31370</name>
        <name evidence="14" type="ORF">CYQ11_24410</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47965">
        <property type="protein sequence ID" value="PHQ47965"/>
        <property type="gene ID" value="BLA24_31370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15589">
        <property type="protein sequence ID" value="PPT15589"/>
        <property type="gene ID" value="CYQ11_24410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="11">
        <location>
            <begin position="64"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="12">
        <location>
            <begin position="702"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ47965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="904" mass="97291" checksum="D277B7FABA80E6A3" modified="2018-01-31" version="1">MSANSFDARSTLQVGDESYEIFKLDKVEGSARLPYSLKVLLENLLRTEDGANITADHIRALGNWDSQAQPSQEIQFTPARVIMQDFTGVPCVVDLATMREAVKELGGDPAKVNPLSPAELVIDHSVIADKFGTKEAFGQNVELEYGRNKERYQFLRWGQTAFDDFKVVPPGTGIVHQVNIEHLARTVMVRGGQAYPDTLVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGELPTGTTATDLVLTITEMLRKHGVVGKFVEFYGEGVAATSLANRATIGNMSPEFGSTAAIFPIDGETLNYLKLTGRSEQQVALVEAYAKEQGLWLDPAAEPDFSEKLELDLSTVVPSIAGPKRPQDRIVLANAAAQFAQDVRNYVDDVDEAGKESFPASDAPAISTGAPSKPVTVTAPDGSTYEIDHGAVTVAAITSCTNTSNPYVMVAAALVAKKAVEKGLTRKPWVKTTLAPGSKVVTDYFDKAGLTPYLDKVGFNLVGYGCTTCIGNSGPLPEEVSKAVNDHDLAVTSVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGSMKVDITKDALGVDTDGNPVYLKDIWPSEAEVNDVVANAIGEDMFNKSYQDVFAGDAQWQALPIPTGNTFEWDAESTYVRKPPYFEGMTMETTPVTDIAGARVLAKLGDSVTTDHISPAGAIKADTPAGQYLTEHGVERRDFNSYGSRRGNHEVMIRGTFANIRLRNQIAPGTEGGFTRDFTKEDAPVSFIYDASRNYIEQGIPLVVLAGKEYGSGSSRDWAAKGTALLGVKAVIAESYERIHRSNLIGMGVLPLQFPEGASAESLGLTGEESFTFTGVTELNEGRTPRTVKVTTDTGVEFDAVVRIDTPGEADYYRNGGIMQYVLRSLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Z4</accession>
    <name>A0A2G1X9Z4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_31780</name>
        <name evidence="11" type="ORF">CYQ11_24835</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48035">
        <property type="protein sequence ID" value="PHQ48035"/>
        <property type="gene ID" value="BLA24_31780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15661">
        <property type="protein sequence ID" value="PPT15661"/>
        <property type="gene ID" value="CYQ11_24835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="102"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="173"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="349"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="426"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="565" mass="62560" checksum="F8892A8D03A39125" modified="2018-01-31" version="1">MAATSETPVAAAPRRKTGRHRGEGQWAAGHFTPLNANEQVKKDDDGLNVRTRIETIYAQRGFDSIDPSDLRGRMRWWGLYTQRKPGIDGGKTAVLAPEELDDEHFMLRVRIDGGRLTTDQLRVVGEVSQEFARGTADITDRQNIQYHWIRIEDVPEIWRRLEAVGLSTTEACGDTPRVVLGSPVAGIAEDEILDGTPAIEEIQRRVVGNPAFSNLPRKFKSAVSGSPLLDVAHEINDVSFVGVVHPEHGPGFDLWVGGGLSTNPRLGVRLGAWVPLDEVPDVYEAVISVFRDHGYRRLRNRARLKFLVADWGAPKFRRVLEEEYLRRPLTDGPAPEQPVERWRDHVGVHRQQDGRFYVGFAPRVGRVDGATLTKIAALAEDHGSGRLRTTAEQKMIVLDVPEAQVASLVAGLEALDLRIAPSPFRRGTMACTGIEFCKLAIVETKARGASLIDELERRLPDFDEPLTINVNGCPNACARIQVADIGLKGQLVLDDHGHQVEGFQVHLGGALGLEAGFGRKVRGLKVTSAELPDYVERVLRRFQEQRTDGERFAQWVARAAEGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA17</accession>
    <name>A0A2G1XA17_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31980</name>
        <name evidence="2" type="ORF">CYQ11_25035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48068">
        <property type="protein sequence ID" value="PHQ48068"/>
        <property type="gene ID" value="BLA24_31980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15694">
        <property type="protein sequence ID" value="PPT15694"/>
        <property type="gene ID" value="CYQ11_25035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="116" mass="13100" checksum="5698C470760A1E61" modified="2018-01-31" version="1">MHGAAVGQMWFEPTVEFRAQMKHGCGDDRWFWRSAELIVPPLREPLGSQGELRAAVRVYGRLAASILEIRKQVLRARVTGHWLPDGGTAVAHYEWRRSGETGRLIPAEEPVVLWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA72</accession>
    <name>A0A2G1XA72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32400</name>
        <name evidence="6" type="ORF">CYQ11_25450</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48134">
        <property type="protein sequence ID" value="PHQ48134"/>
        <property type="gene ID" value="BLA24_32400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15760">
        <property type="protein sequence ID" value="PPT15760"/>
        <property type="gene ID" value="CYQ11_25450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="247" mass="27501" checksum="63C44FABB994C203" modified="2018-01-31" version="1">MAVDPLIELRDVNKYYGKLHVLRDINLTVGRGEVVVVIGPSGSGKSTLCRTINRLEPVESGTITLDGRPLPDEGRALARLRAEVGMVFQSFNLFAHKTVLANVSLAQIKVRRRSREEADRRSRELLERVGLLAHAEKYPAQLSGGQQQRVAIARALAMDPKALLFDEPTSALDPEMITEVLEVMQQLAREGSTMVVVTHEMGFARSAANRVVFMADGRIVEDRTPEEFFTAPRSERAKDFLSKILKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA86</accession>
    <name>A0A2G1XA86_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48079">
        <property type="protein sequence ID" value="PHQ48079"/>
        <property type="gene ID" value="BLA24_32055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="302" mass="31723" checksum="D308F92B1A99A523" modified="2018-01-31" version="1">MRENADSARECAGRGGPGCPRHVQDLEPLSRLVEDLVGRASAGHPAAALVAPLEYSVAVQKGALEAIKSALAQAGGSGTGRRRDAPVTALDGARRAGPALREAVAACREELLVAQPVGRRPRGGWADLGPPGAGPQLRHGVAVRYLRGASPVGAADGQADDVRQALAAGAEVRVAGLLLERLVVCDRTIAFLPAHDEDCGPCLEVRHPALVRHLALAFDTAWRAARPVAAADGAPERPRDELRHAVLRMMVEGHTDEVIARRLGVSPRTVAAHVRREAVSLGSRSRAQLGYLLARSGMRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAQ7</accession>
    <name>A0A2G1XAQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_33380</name>
        <name evidence="2" type="ORF">CYQ11_26430</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48295">
        <property type="protein sequence ID" value="PHQ48295"/>
        <property type="gene ID" value="BLA24_33380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15926">
        <property type="protein sequence ID" value="PPT15926"/>
        <property type="gene ID" value="CYQ11_26430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="76" mass="7905" checksum="DC9AE0F13F96505C" modified="2018-01-31" version="1">MNPLYFKRNVPSSTPPRRLAAHPAVGHNVLDHGLGLRADGDACKKLGEAAGRVQPQPLAPLGIVDAGAFGGEVQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAR5</accession>
    <accession>A0A346M2I6</accession>
    <name>A0A2G1XAR5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BcmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bcmC</name>
        <name evidence="6" type="ORF">BLA24_33490</name>
        <name evidence="7" type="ORF">CYQ11_26540</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <title>Biosynthesis of biocyclomycin.</title>
            <authorList>
                <person name="Meng S."/>
                <person name="Pan H.-X."/>
                <person name="Tang G.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MG018995">
        <property type="protein sequence ID" value="AXQ04974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XAR5"/>
    <dbReference type="EnsemblBacteria" id="PHQ48316">
        <property type="protein sequence ID" value="PHQ48316"/>
        <property type="gene ID" value="BLA24_33490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15947">
        <property type="protein sequence ID" value="PPT15947"/>
        <property type="gene ID" value="CYQ11_26540"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AXQ04974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="305" mass="33595" checksum="5F8DA3D1140E5529" modified="2018-01-31" version="1">MSTETLRLQKARATEEGLAFETPGGLTRALRDGCFLLAVPPGFDTTPGVTLCREFFRPVEQGGESTRAYRGFRDLDGVYFDREHFQTEHVLIDGPGRERHFPPELRRMAEHMHELARHVLRTVLTELGVARELWSEVTGGAVDGRGTEWFAANHYRSERDRLGCAPHKDTGFVTVLYIEEGGLEAATGGSWTPVDPVPGCFVVNFGGAFELLTSGLDRPVRALLHRVRQCAPRPESADRFSFAAFVNPPPTGDLYRVGADGTATVARSTEDFLRDFNERTWGDGYADFGIAPPEPAGVAEDGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB04</accession>
    <name>A0A2G1XB04_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VioB-polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32850</name>
        <name evidence="3" type="ORF">CYQ11_25900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48381">
        <property type="protein sequence ID" value="PHQ48381"/>
        <property type="gene ID" value="BLA24_32850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15836">
        <property type="protein sequence ID" value="PPT15836"/>
        <property type="gene ID" value="CYQ11_25900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like" evidence="1">
        <location>
            <begin position="681"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1096" mass="118403" checksum="3E99FA229A956D68" modified="2018-01-31" version="1">MSVFDLPRLHFAGTATTKLPTGPRSGLVDLATGRALTGDGPFPTDRPAAEYHDYLQRLGPRFDGEGRPDGEGEFSAAKGWHFDGNGHFWLDARIVSAEHPGGGAPDTGDPVVGRSVDVWGHYNAYLRTTVNRARVFDLDPASRWTTALMVGRFGFGRLGRSHDDGYMLMGEVEGFHPPRWADFRRILDVGEHALAEQLRYGAVHQFVVTGEDGPGSALQWLPDADLSPAALALRTAVEGGADGLVVRFALDDMASPRVPDTPAQWRVRGTIAPWHAHELRTYPAGRLLVPTADAAGRLHHCTVDLADGRAAFDMVSAVPVTHRAREAGPGLLHRLGPPVDAGDLELRTAGSGRLVALLPSGSYPGDLTSGLVAVPAEPGWERAAGEGLCLTGTGADGRRVTLAREREVNVQSDESLVVLHHRDRANGRDHAVGVPLRAYVRGRPASAGRVRVRQFYNPRALPADGRAGAPGARCGDAVVLGVRGEGPFAEECVVETDEHGHGLLVLRGERAGTCRVLLSAGAEDGPPGVDPRAEGSAWAAYDDEDALGFWAGAGSLAVRVLPDDWHLDDVPREDVDFELLHREVFAYYEHVSTFMRSEVFSLADRCKVETYAELAWQMCDPRNKPKTYYMPPTRDLSDPKARLLLAYLRNLQARTRPPLAVPARSPVGPVIGTRGELWTVLKQAATLELAVMLQYLYAAFSVPTHGAGREYVRRGSWTARQLELACGQGGATLDDGIRGILLNVAREEMIHFLLVNNIITAMGEPFHIPAIDFATLNSELPVPLDFALEGLSVGSVERYVAIEQPAGLTPELRCAGRPETAGGVAAAEAAPTAWGSVSELYAAIREGLQRVPDLFLVDKGRGGGEHHVFMRESVNSRHPDYQLEVDDLQSALFAVDFITEQGEGGALGPAAPSDSSHFQSFLRIGEVLTSERVPGPYGRLLPWSPAYPVLRNPTLGPGGDGAKDPVTDPEARAVGRLFNHSYHLMLQLMAQHFGQSPDGSLRRSKLMNASIDVMTGVMRPLAELLVTMESGRRGRTAGPTFELADVPGVTPRPDVARRALALRFAHLSAAARKCGPVPPQVAEMTAFYADFFRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB72</accession>
    <name>A0A2G1XB72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29310</name>
        <name evidence="3" type="ORF">CYQ11_06165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48466">
        <property type="protein sequence ID" value="PHQ48466"/>
        <property type="gene ID" value="BLA24_29310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12537">
        <property type="protein sequence ID" value="PPT12537"/>
        <property type="gene ID" value="CYQ11_06165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="91" mass="9785" checksum="CA8C29771EAE7065" modified="2018-01-31" version="1">MDQIAMRSRPRVPAISHGGGASSARLDRHLAVLGGPALPRPEVEGATVLMRELTARDHARAGQSRTARVSLFAPLRRLRRSLFGSHGTSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBB2</accession>
    <name>A0A2G1XBB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29525</name>
        <name evidence="3" type="ORF">CYQ11_05950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48500">
        <property type="protein sequence ID" value="PHQ48500"/>
        <property type="gene ID" value="BLA24_29525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12501">
        <property type="protein sequence ID" value="PPT12501"/>
        <property type="gene ID" value="CYQ11_05950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="37146" checksum="7ED1E0FF66511F00" modified="2018-01-31" version="1">MRLGINLGYWGAGMDADNLEVAREADRLGYSVCWAAEAYGSDAPTVLAWVAAQTERIDVGSAILQIPARTPTMTAMTAATLDSLSGGRFRLGLGVSGPQVSEGWYGVKFDKPLARTREYVEVIRKAMSRERVAHDGQHWTLPLPGGPGKPLKLTVHPVREHIPLYIAAIGPKNLEQTGEIADGALVVFFAPEHAEETTLGALRAGRAKAGKDLEGFDLVPTVPLAVGDDVDALADLFRPYTALYVGGMGSAKQNFYNKLAQRMGYEKAAAEIQEKYLSGDKAGAAAAVPRELIDSTALLGPVERIADRMRAYADAGVTTLSLAPAGFTLDERIAGLRTAVTALERAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBM4</accession>
    <name>A0A2G1XBM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Export associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28290</name>
        <name evidence="4" type="ORF">CYQ11_07180</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48622">
        <property type="protein sequence ID" value="PHQ48622"/>
        <property type="gene ID" value="BLA24_28290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12698">
        <property type="protein sequence ID" value="PPT12698"/>
        <property type="gene ID" value="CYQ11_07180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="668" mass="69835" checksum="FD145DF128D5C98F" modified="2018-01-31" version="1">MTAELVRGQNHPLSGTRLEIRVSAGHPVVAGATLGDAEGRVPGADGVAHPAAPRLPGVEVSRQAAAEHRLAFDLEAVSEAVHRVSIVLALPSGVGGPVRFGALAAPFVAVTDLDGTEIASYTITDLEAETAVVAVELYRRQGAWKVRAVGQGYAGGLASMLADHGIPQAAELAASIDEAVAQGMARAVVPPPARLATGEGAGRGSAPAADVRGSAADGRSVPDAAAEATGPDGLDPTVSLPAQGVGGADEAPGRQPGGASGPISYQHPGRRTSTPPEPAPAAPAAEPGRAGAPVAGDATGWTMNERLYNQVWGMFEDLARAAAAYRSAVDFAESRLEQELDRVLSDPSTRVGPAADAARAQARARHGELMDQARAVLDRDLTQLAAEAEVVEHALPPAYARWDSPVWQGYQVPLERPMALRLGDLHLPERKDLRIPMLVRLPLERGLWIDSGRSSGGVDAALVDSAELRRLAVDCAVAQAVRLLAVHPVGDYTVHVIDPAGSAGTALAPLLEYGALKEQPAAGAQGVSEVLARLTRRVDLVQMAVRSGAVDALPPDVDTAEQLLLVNDFPHGFDDRAVTQLRYLADEGPAVGVHLVMIADRDDARAYGPVLDPLWRSLLRVTPVPDDHLADPWVGHAWTYEPSMAPAGSDVVRQVLWQVGQARRAYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC37</accession>
    <name>A0A2G1XC37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27165</name>
        <name evidence="7" type="ORF">CYQ11_18490</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48761">
        <property type="protein sequence ID" value="PHQ48761"/>
        <property type="gene ID" value="BLA24_27165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14591">
        <property type="protein sequence ID" value="PPT14591"/>
        <property type="gene ID" value="CYQ11_18490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="13"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="502" mass="52965" checksum="918259390EB4E78A" modified="2018-01-31" version="1">MSSVETIHVDGVWRAATSGAQREVLDPADATVLAVVAEGGADDTDAAVAAASRAFDGGAGVWPRTSVAERAALLRRVAELLQRDREEIALIESRDTGKTLEEGRIDVDCVSDAFRYFADLVVGEGAGRVVDAGSDTVHSVVVHEPVGVCAMITPWNYPLLQASWKIAPALAAGNTFVIKPSEVTPLSTVHLVRLLAEAGLPDGVANIVTGAGDPVGARLAEHPDVDLVSFTGGLTSGVKVAQAAAPSVKKVALELGGKNPNVVFADACATDEDFDTAVDQALNAAFIHSGQVCSAGSRLIIEESVRDRFVSELARRAERIKLGRGTEKGVECGPLVSAEQLAKTEAYVASALAEGAALRCGGRRPAPAPGRPETGYFYAPTVLDLCHGAMRVVREETFGPILTVETFHTEDEAVALANDTEYGLAGAVWTKDAGRARRVAGRMRHGTVWINDFHPYLPQAEWGGFGKSGTGRELGPTGLAEYRETKHVYQNLAPAPVRWFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC60</accession>
    <name>A0A2G1XC60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27400</name>
        <name evidence="3" type="ORF">CYQ11_18245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48800">
        <property type="protein sequence ID" value="PHQ48800"/>
        <property type="gene ID" value="BLA24_27400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14550">
        <property type="protein sequence ID" value="PPT14550"/>
        <property type="gene ID" value="CYQ11_18245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758317" evidence="1">
        <location>
            <begin position="33"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="437" mass="46818" checksum="B36122906BB09B1A" modified="2018-01-31" version="1">MHRRIPFVAGAAAATLTTVLATVLAAAPGAFAAGPDPHGGSTQRVEYFTEPGGHPHHTTVPAAPRTPVQALRPWVKGDGTVTSVVDNGPVGAKLDVVFVGDGYTATEQEAFHAAVRAKWAKMSAVEPYASNRGLFNVWAVDAVSSDSGVSGDPVQGVVKNTALGSRFFCDGVERLLCVDTAKVESYAAKAPAADLVVVLSHSAKYGGAGYNDVVSKVGYDGIATASSDHDKSDQVAVHETGHSLGKLADEYQYDEYGTYTGDEPRDVNVSTFESGAMNDRRQKWYRWLGQTSPDGGTVGSFEGGGYYPKGLFRPTENSIMRSLGREFNLPGREAMVAGFYRHARVLSSDSGPDGKVSRWERVVVRPAAARVDLRWYVDGREVVQARGHTDVLPRQMGVPADGRPHTLTARATDTTDAVRDPELRKRLTTTLSWRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC63</accession>
    <name>A0A2G1XC63_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000157">
        <property type="protein sequence ID" value="PHQ48749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48749">
        <property type="protein sequence ID" value="PHQ48749"/>
        <property type="gene ID" value="BLA24_28095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="113" mass="12146" checksum="A14A6FC6308B07C4" modified="2018-01-31" version="1">MTALGVISSLYVQVIHEDWVDRQQAACRIMARPQMEFVVAWGGPALGVAAVILCVLLARRTRRRHGVRLGETWPGLIAYLSVGANALAILLELFMLYAAFSSDGSGSVLGDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC89</accession>
    <name>A0A2G1XC89_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2975 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein TPRXL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27570</name>
        <name evidence="4" type="ORF">CYQ11_18075</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48830">
        <property type="protein sequence ID" value="PHQ48830"/>
        <property type="gene ID" value="BLA24_27570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14524">
        <property type="protein sequence ID" value="PPT14524"/>
        <property type="gene ID" value="CYQ11_18075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758394" evidence="2">
        <location>
            <begin position="38"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="194" mass="20309" checksum="92D97C5E3B61BC8A" modified="2018-01-31" version="1">MNTRLTRTLASVTFVLAVLCGLAFVGTAVTHMLDDGAVCVQTDFWRNASIGEGLPIGKGVKASSSATRLCQDGPSTGQRAADLGGELPWLLFGSLALLLFSRLLKAVLRQGPFTDTVSRRLSVLGWFVALGAPLAGLVVGWSQSWLVGSMAPVVGSGPTVSGPMVLILAGLAAVIWGKIMRDGVRMREDLEGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB6</accession>
    <name>A0A2G1XCB6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27605</name>
        <name evidence="3" type="ORF">CYQ11_18035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48835">
        <property type="protein sequence ID" value="PHQ48835"/>
        <property type="gene ID" value="BLA24_27605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14519">
        <property type="protein sequence ID" value="PPT14519"/>
        <property type="gene ID" value="CYQ11_18035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045590">
        <property type="entry name" value="DUF6463"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20064">
        <property type="entry name" value="DUF6463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13444" checksum="7F7482B7867716A6" modified="2018-01-31" version="1">MIKGAGWLLVFLGAAHTLLALTMEGAARHAGEWFSGALWGEDFSDMSPAGSALWLSLESFGPPLLVVGLIVLWLDRRGITPPPFIAWTLGIWGVVDAVVLITTPWPLFLLANILLLVGGRRAAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCL9</accession>
    <name>A0A2G1XCL9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ORF">BLA24_23035</name>
        <name evidence="10" type="ORF">CYQ11_23040</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48983">
        <property type="protein sequence ID" value="PHQ48983"/>
        <property type="gene ID" value="BLA24_23035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15372">
        <property type="protein sequence ID" value="PPT15372"/>
        <property type="gene ID" value="CYQ11_23040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="329" mass="35973" checksum="162D96685815CBA7" modified="2018-01-31" version="1">MDIDMSALRGLVREKEISFDLLVEAIESALLIAYHRTEGSRRRARVELDRSSGHVTVWAKEDPQDLAEGEEPREFDDTPSGFGRIAATTAKQVILQRLRDAEDEITFGEFAGREGDVVAGVVQQGKDPKNVLVDIGKLEAILPVQEQVPGEEYKHGTRLRTYVVRVAKGVRGPSVTLSRTHPNLVKKLFAMEVPEIADGSVEIAAIAREAGHRTKIAVRSTRSGLNAKGACIGPMGGRVRAVMAELHGEKIDIVDWSDDPAELVAHALSPARVSKVEVVDLAARSARVTVPDYQLSLAIGKEGQNARLAARLTGWRIDIRPDTEQQQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM4</accession>
    <name>A0A2G1XCM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22860</name>
        <name evidence="3" type="ORF">CYQ11_23215</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48951">
        <property type="protein sequence ID" value="PHQ48951"/>
        <property type="gene ID" value="BLA24_22860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15404">
        <property type="protein sequence ID" value="PPT15404"/>
        <property type="gene ID" value="CYQ11_23215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="89" mass="9501" checksum="57DDE0596B648187" modified="2018-01-31" version="1">MFLPQLPLGGAPSREHVPFAFVAEAERYRSNVTPPPRDRISRSEIVGRTLVGLTVAAGLVGALLFGTPALESGPQNTHRTQHSEANAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCS7</accession>
    <name>A0A2G1XCS7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_23100</name>
        <name evidence="6" type="ORF">CYQ11_22975</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48995">
        <property type="protein sequence ID" value="PHQ48995"/>
        <property type="gene ID" value="BLA24_23100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15360">
        <property type="protein sequence ID" value="PPT15360"/>
        <property type="gene ID" value="CYQ11_22975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="292"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="469"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="533" mass="55671" checksum="F4608F336800E80A" modified="2018-01-31" version="1">MPPTLASLVHHSALKLSVLAGQDRLDTPVRWAHVSELADPVPWMDGGELLLITAMKIDAEDPEAMRGYVRRLVRAGVAGLGFAVGVNYEHVPQALIRAAEEEGLPLLEVPRRTPFLAITKAVSAALAADQYRAVTAGFEAQRELTRAALAPEGPAALLARLAAHLGGWAALYDASGAVVAAAPDWAARRAARLGAEVARLRERPAPASAVVGADAEGEGGDRVELQTLGSGRRARGVLAVGTDAPLGTAERYAMHSAVALLTLTTERSRTLLDAEQRLAAAVLRMLLAGEPDHARAVAGELYGGLLDGPFRILVAEAAEGQGDADAVLGALADAVETAASRAAEPVLAVAEGDRIVVLAPDGGAAVAACAAYAHAAEARRGTAPEQPVPAPQAALGLSAPAGPTAAGAAFHQAEQALSVARRRGRVLVEHEEVAAGSVLPLLADDAVRAFADGMLRALYQHDATGRGDLVASLRAWLARHGQWDAAAADLGVHRHTLRYRMRRVEEILGRSLDDPDVRMELWLALKATAERPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT1</accession>
    <name>A0A2G1XCT1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="13" type="ORF">BLA24_23210</name>
        <name evidence="14" type="ORF">CYQ11_22865</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49011">
        <property type="protein sequence ID" value="PHQ49011"/>
        <property type="gene ID" value="BLA24_23210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15345">
        <property type="protein sequence ID" value="PPT15345"/>
        <property type="gene ID" value="CYQ11_22865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="115"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="241"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ49011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="40366" checksum="E8B967AFEE7C705F" modified="2018-01-31" version="1">MPAPGELTFVAPRGAKLPPRHLADLSPAERREAVAAIGEKPFRAKQLSQHYFARYAHDPAAWTDIPAASREKLAADLLPDLMSVVRHISCDEDTTRKTLWRLHDGKLVESVLMRYPDRVTMCISSQAGCGMNCPFCATGQAGLDRNLSTAEIVHQIVDGMRALRDGEVPGGPARLSNIVFMGMGEPLANYKRVVGAIRRLTDPEPDGLGLSQRGITVSTVGLVPAMHRFADEGFKCRLAVSLHAPDDELRDTLVPVNTRWKVREVLDAAWEYAEKSGRRISIEYALIRDINDQAWRGDLLGRLLKGKRVHVNLIPLNPTPGSKWTASRPEDERAFVAAIAAHGVPVTVRDTRGQEIDGACGQLAAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCV6</accession>
    <name>A0A2G1XCV6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pruA</name>
        <name evidence="10" type="ORF">BLA24_23680</name>
        <name evidence="11" type="ORF">CYQ11_22395</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49087">
        <property type="protein sequence ID" value="PHQ49087"/>
        <property type="gene ID" value="BLA24_23680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15267">
        <property type="protein sequence ID" value="PPT15267"/>
        <property type="gene ID" value="CYQ11_22395"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="56"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="543" mass="58432" checksum="B9E035D44A8BFE40" modified="2018-01-31" version="1">MDAVTQVPAPVNEPVHSYAPGSPERARLEAKLKELAANPIDLPMTIGGEKRMGGGEPFKVVQPHNHAAVLGTFHHATTQDAQDAIDAALAAAPAWRAMSFDDRAAIILRAAELLAGPWRETLAASTMLGQSKTAQQAEIDTPCELVDFWRFNVHFARQILAEQPVANSAGVWNRSDHRPLEGFVYAITPFNFTAIAGNLPTAPALMGNVVVWKPSPTQTHSAVLLMQLLEEAGLPKGVINLVTGDGIAVSEVALNHPELAGIHFTGSTKTFQYLWKTVGTNIEKYKSYPRLVGETGGKDFVVAHPSADRAVLKTALTRGSFEFQGQKCSASSRAYVPRSIWEDGFREEFAAEVDGITMGDVTDLSNFIGAVIDERSFAKNKAAIDRAKADPSCTIVAGGTYDDSVGYFVRPTVIECTDPENEVFTTEYFGPILAVHVYEDADFDAMLAQMESVSAYALTGSVIAADRYAAADAMEKLRFAAGNFYINDKSTGAVVGQQPFGGGRASGTNDKAGAASNLQRWVSTRSIKETLVPPTDYTYPHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD67</accession>
    <name>A0A2G1XD67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24140</name>
        <name evidence="4" type="ORF">CYQ11_21935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49160">
        <property type="protein sequence ID" value="PHQ49160"/>
        <property type="gene ID" value="BLA24_24140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15190">
        <property type="protein sequence ID" value="PPT15190"/>
        <property type="gene ID" value="CYQ11_21935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="139" mass="15646" checksum="8EBFF1EF29F59579" modified="2018-01-31" version="1">MTVAKEIMHPGAQWISRDVTLDEAARLMRELNVGALPVADENERLCGIVTDRDIVVKCVADRRDPATCTAAELCEGTPRWIDANADVEEVLHEMENHRIKRLPVIENKRLVGIITEADLAQHLTDDQIAEFAEMVYARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDA8</accession>
    <name>A0A2G1XDA8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24435</name>
        <name evidence="3" type="ORF">CYQ11_21635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49216">
        <property type="protein sequence ID" value="PHQ49216"/>
        <property type="gene ID" value="BLA24_24435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15133">
        <property type="protein sequence ID" value="PPT15133"/>
        <property type="gene ID" value="CYQ11_21635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="14958" checksum="4971E6172B0AAD57" modified="2018-01-31" version="1">MQSNDARTLMQCAVPTAVAGVVAVAAGFVLAGGKGAIGAAVGTAVAGGVMAMGLFVLQRTAKSFPHLFQAMGLVLYVTQFLISAVVLAVFRDTSLFNTRAFAFALLGAVLVWTAAQTRAYMKAKILYVEPEASEARESTPAGSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF2</accession>
    <name>A0A2G1XDF2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1857 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24725</name>
        <name evidence="2" type="ORF">CYQ11_21345</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49267">
        <property type="protein sequence ID" value="PHQ49267"/>
        <property type="gene ID" value="BLA24_24725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15081">
        <property type="protein sequence ID" value="PPT15081"/>
        <property type="gene ID" value="CYQ11_21345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="DUF1857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="158" mass="17728" checksum="EC9BD868A3F87305" modified="2018-01-31" version="1">MRIEVTLPVNDPARPDQPRLDRAQVWDGLLRKAEYAVPFVPGMTECTVLERRENGLVREVVVDGERITEEVTFEPPLLVSFFRRDDRASWVIRNRIGEDAAGSLTLTFIGDMPHPATPGATAAEGQSREEVLEEMRARTLETVRNTLEVIRRTATAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDN0</accession>
    <name>A0A2G1XDN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_25165</name>
        <name evidence="6" type="ORF">CYQ11_20905</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49344">
        <property type="protein sequence ID" value="PHQ49344"/>
        <property type="gene ID" value="BLA24_25165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15008">
        <property type="protein sequence ID" value="PPT15008"/>
        <property type="gene ID" value="CYQ11_20905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304858" evidence="3">
        <location>
            <begin position="27"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="405"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="510" mass="53088" checksum="6A82E2CC306DC82C" modified="2018-01-31" version="1">MGAVSSSLRVGALLSAVLLAVATASGCSGGDGGASTPGPGASANQKLDWKSCPAPSTSEDSGSGKPPGRDWECATLRAPLDYADPDGETIGIALIRAKATDQAHRIGSLIFNFGGPGGSGVSTLPAFAEDYRTLRTRYDLVSFDPRGVGRSAAVTCLNDKQLDAYYAADATPSTKEEEKALVGRVGDYAEACRKNSGKILPHVGTTNAARDMDLMRQVLGDDKLHYFGVSYGTELGGVYAHLFPGRVGRALLDGVVDPASDPVQSALAQAAGFQLALGNYMASCVKTSDNCPTEQQIVALLDRLGKKAVPGGGGRDLTQSLAMGGIAQSLYSKDFWDYLTEGVEDAENGDGKMLLTLGDSMNGRGPDGKYSSLQASLNAITCADFAQRYTAEEVEQKTAEFRKASPVFGEFMAWSLLQCTGWPVKGEWQTPDVSAKGSAPILVVGNTGDPATPYEGAHKMAQELGPGVGVVMTYQGEGHGAYDSGNACVKSAADAYLLQGTVPPAHKVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDR6</accession>
    <name>A0A2G1XDR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25275</name>
        <name evidence="3" type="ORF">CYQ11_20795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49362">
        <property type="protein sequence ID" value="PHQ49362"/>
        <property type="gene ID" value="BLA24_25275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14989">
        <property type="protein sequence ID" value="PPT14989"/>
        <property type="gene ID" value="CYQ11_20795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="49"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="317" mass="34861" checksum="0F2B35F7A7D7B6AA" modified="2018-01-31" version="1">MTNYWSVDPSRGTGPGPQYLAEIAAGIERTNELLTRVLAEVATTPATHAVFADAGYVYAAAGRLVTGTEDRRTFELDAEGLIEAFIDKARSIFPDSRLLRVYWYDGARRRIHTAEQQGIAELPDVKVRLGNLNANNQQKGVDSLIRTDLESLARHRAISDAVLIGGDEDLVSAVEAAQGYGARVHLWGIEAVGGRNQAEALLWEVDSQRTFDLEFCKPYVTRRTGYEPPVEERAVQGPAPSREDVRFVGARVAAQWLGSRGRASLAELLPGHPYLPGGVDQELLVEAEALLGLSLRGHAELRRALRDGFWDHLRAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDT8</accession>
    <name>A0A2G1XDT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25380</name>
        <name evidence="2" type="ORF">CYQ11_20695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49382">
        <property type="protein sequence ID" value="PHQ49382"/>
        <property type="gene ID" value="BLA24_25380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14969">
        <property type="protein sequence ID" value="PPT14969"/>
        <property type="gene ID" value="CYQ11_20695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="21041" checksum="0FD8DAB32FD91D13" modified="2018-01-31" version="1">MSDGAAVLGPDGLARCPWGGLAAASAEDYRVYHDTEWGRPVHGDDALYERICLEAFQSGLSWLTVLRRREGFRAAFAGFSIEKVAAFTPADEERLLADPGIIRNRAKITAAVENARAAERLGEGELDALVWSFAPAAGRPVPRTSADVPAITAESTALAKDLKKRGFRFVGPTTAYALMQACGLVDDHLADCHVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDZ4</accession>
    <name>A0A2G1XDZ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antirestriction protein ArdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25795</name>
        <name evidence="2" type="ORF">CYQ11_20275</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49457">
        <property type="protein sequence ID" value="PHQ49457"/>
        <property type="gene ID" value="BLA24_25795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14893">
        <property type="protein sequence ID" value="PPT14893"/>
        <property type="gene ID" value="CYQ11_20275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041895">
        <property type="entry name" value="ArdA_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="180" mass="20282" checksum="50782739A0BF3E4D" modified="2018-01-31" version="1">MPTLSTAIRPTVWIGCLACYNAGRLTGDWYDADIANLVTPEDLHGRPTLHEELWVMDHEDFCGALEGECSPSEAAEIAEALSELTHDEAAAFSVWVREWGESGDRSGWVDRFRSEYRGFHDSEGHFAQEWAEETSEPENRARMSVWPFNAIDWDYAAQELFSGGFHAEEVLGGVHVFCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE02</accession>
    <name>A0A2G1XE02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25830</name>
        <name evidence="2" type="ORF">CYQ11_20240</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49463">
        <property type="protein sequence ID" value="PHQ49463"/>
        <property type="gene ID" value="BLA24_25830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14887">
        <property type="protein sequence ID" value="PPT14887"/>
        <property type="gene ID" value="CYQ11_20240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="92" mass="10077" checksum="67E9A2BD52665756" modified="2018-01-31" version="1">MNIATQGVSLAKASDLTAGLSVDAQLQNLQERVWMLARELDAVNAELAVRRDIELELVRFSFETAVENEVLRDTVEVLSVSLGLELGLTLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE18</accession>
    <name>A0A2G1XE18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25785</name>
        <name evidence="2" type="ORF">CYQ11_20285</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49455">
        <property type="protein sequence ID" value="PHQ49455"/>
        <property type="gene ID" value="BLA24_25785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14895">
        <property type="protein sequence ID" value="PPT14895"/>
        <property type="gene ID" value="CYQ11_20285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="94" mass="10735" checksum="36384762732A95C1" modified="2018-01-31" version="1">MTNIPMTDRIKHLVNELDEAVKTMRQEPEDGRTWSWEDEHVAGLNLADAAEALILALPAAIWPPSWFKEEPEQARPLTPYEKQLVDELLEQLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE22</accession>
    <name>A0A2G1XE22_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25910</name>
        <name evidence="2" type="ORF">CYQ11_20160</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49476">
        <property type="protein sequence ID" value="PHQ49476"/>
        <property type="gene ID" value="BLA24_25910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14874">
        <property type="protein sequence ID" value="PPT14874"/>
        <property type="gene ID" value="CYQ11_20160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020132">
        <property type="entry name" value="Gp24/Gp25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17388">
        <property type="entry name" value="GP24_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="112" mass="11933" checksum="A63E57F3E526CAB5" modified="2018-01-31" version="1">MASFSLDDIRNAAEARYGSTDIELGDETVRLLNPLRLPKDTRTKLSQLQDDMGGEDADQEELLSEAIRLVAEHATAADKLLKAVGGDLAVLAEIFDRYGKGAQVGEASASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE37</accession>
    <name>A0A2G1XE37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antitoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Type II toxin-antitoxin system RelE/ParE family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25700</name>
        <name evidence="3" type="ORF">CYQ11_20370</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49439">
        <property type="protein sequence ID" value="PHQ49439"/>
        <property type="gene ID" value="BLA24_25700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14911">
        <property type="protein sequence ID" value="PPT14911"/>
        <property type="gene ID" value="CYQ11_20370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="87" mass="9880" checksum="403370202A479414" modified="2018-01-31" version="1">MSEYRAVFRPEAQAGLRKIPRDTALRILAKPTELESHPFGFDTTALVSQPERRRLPVGDYRVVCTIDNGELVVWVVHVGHRSTLHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEA9</accession>
    <name>A0A2G1XEA9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49574">
        <property type="protein sequence ID" value="PHQ49574"/>
        <property type="gene ID" value="BLA24_26480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013961776" evidence="1">
        <location>
            <begin position="28"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="261" mass="26401" checksum="ADEE834542C29FF2" modified="2018-01-31" version="1">MLRALRTLGLAVLAAGLTLTATPAATAAPAAATAPARELTPVGGGTGIIFRMTPTPEERQGFYVCTLTAVGRDNAGNLVGLTNAHCFIDEKGNKLVGEKVYRDTSPAGTAAAPADLNASRPDLETGPIGTVTSVSTPNNLLNAGPKGLDFAVIKLDESRVAPTATVGGVTISSIGAPPANGTRMCKQGHRTGLTCGIKLGTHDIWFTHLIWTNGGDSGSPVVSGQTLVGNAWGAQHSSAILDIIAEMNANGGVGAGFHLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEB0</accession>
    <name>A0A2G1XEB0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26445</name>
        <name evidence="3" type="ORF">CYQ11_19195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49568">
        <property type="protein sequence ID" value="PHQ49568"/>
        <property type="gene ID" value="BLA24_26445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14713">
        <property type="protein sequence ID" value="PPT14713"/>
        <property type="gene ID" value="CYQ11_19195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="9457" checksum="2205A565100FC183" modified="2018-01-31" version="1">MSGHDRKEDEVRRMLEGRHPALPPDVVRRAAEEGRRLLRRRRAVRAVGWALLVAVVVAFCVWAAVAEPWAARPAERTPPLRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC4</accession>
    <name>A0A2G1XEC4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aspA</name>
        <name evidence="2" type="synonym">fumC</name>
        <name evidence="5" type="ORF">BLA24_26160</name>
        <name evidence="6" type="ORF">CYQ11_19480</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49519">
        <property type="protein sequence ID" value="PHQ49519"/>
        <property type="gene ID" value="BLA24_26160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14761">
        <property type="protein sequence ID" value="PPT14761"/>
        <property type="gene ID" value="CYQ11_19480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="407"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="103"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="323"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="466" mass="49386" checksum="F65B6BB9C2713C41" modified="2018-01-31" version="1">MTMTDDEQYRIERDSMGEVRVPAGAKWRAQTQRAVENFPVSGQRLERAHIAALGRIKAAAAKVNAELGVLDADVAAAVAEAATEVAEGRWDDHFPVDVFQTGSGTSSNMNANEVIATLAGERLGRPVHPNDHVNASQSSNDVFPSSIHIAATAAVTGDLIPALEHLEAALARKAEEFAEVVKSGRTHLMDATPVTLGQEFGGYAAQVRYGAERLRASLPRLAELPLGGTAVGTGINTPPGFSGAVIAEVARTTGLPLAEARDHFEAQGARDGLVETSGQLRTIAVGLTKIANDLRWMASGPRTGLAEINLPDLQPGSSIMPGKVNPVVCEAVLMVAAQVTGNDLTVATAGAAGNFELNVMLPVMAKNVLESVRLLANASRLLADRTVDGITANVERAREYAESSPSVVTPLNRYLGYEEAAKVAKKSLAERKTIREVVLESGYVERGLLTTEQLDEALDVLRMTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL4</accession>
    <name>A0A2G1XEL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23120</name>
        <name evidence="3" type="ORF">CYQ11_22955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49684">
        <property type="protein sequence ID" value="PHQ49684"/>
        <property type="gene ID" value="BLA24_23120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16740">
        <property type="protein sequence ID" value="PPT16740"/>
        <property type="gene ID" value="CYQ11_22955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="36"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="465" mass="51115" checksum="E1D62FCE806BC376" modified="2018-01-31" version="1">MNPVRALSDALPRPYWLDDPARPDALPALVGDEHCDLLVVGGGYSGLWTALRAKERDPGRDVVLIEGQEAGWAASGRNGGFCAASLTHGWANGLARWPAELTALERLGRRNLDAIEDTVARHRLDCDFERTGEIDVATAPHQVRELREAAAEAAAAGVTGHEFLDRDALRAEVDSPTFLAGLWNRTGVAMVHPAKLAWGLKRACLELGVRVYEHTPGTGLSARRAGVAVRTPYGRVFARHAALGTNAFPSLVKRLRPYIAPVYDYALMTEPLTTEQLASVGWRGRQGLSDSANHFHYFRLTADRRVLWGGYDIVYRYGGGVRAEYDHHPATYQRLAGHFFRCFPQLEGVRFSHTWGGAIDTCSRFSAFFGTAHRGRVAYALGFTGLGVGATRFGADVMLDLLSGERTERTELEMVRSKPLPFPPEPVRSVGIGITQWAMTRADENGGRRNLWLRALDRVGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEP5</accession>
    <name>A0A2G1XEP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23430</name>
        <name evidence="3" type="ORF">CYQ11_22640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49696">
        <property type="protein sequence ID" value="PHQ49696"/>
        <property type="gene ID" value="BLA24_23430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16728">
        <property type="protein sequence ID" value="PPT16728"/>
        <property type="gene ID" value="CYQ11_22640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="222" mass="24423" checksum="F0A83518631D4EBD" modified="2018-01-31" version="1">MGRPSPQRRKQEALNARLDPRNPLVFDTRELGRRPGALKRVSRSVPAPQDLGIEVIGVPQDATVGLDLRLESVMEGVLVTGTARAPLTGECVRCLEPLERELEVDFQEMYSYPDADDRSRHADTGDDAEDDEEDMLFLEADLFDLEPVLRDAVVLALPLQPVCQEDCPGLCSECGARLADDPDHHHETVDIRWAALQGLAGSDQDGEKDNAPRSGGDDSQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF34</accession>
    <name>A0A2G1XF34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19570</name>
        <name evidence="5" type="ORF">CYQ11_11225</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49842">
        <property type="protein sequence ID" value="PHQ49842"/>
        <property type="gene ID" value="BLA24_19570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13382">
        <property type="protein sequence ID" value="PPT13382"/>
        <property type="gene ID" value="CYQ11_11225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="2">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="19739" checksum="8496721CAEB77D87" modified="2018-01-31" version="1">MTTPTAPPTTARLDLLVGDVREAVGRGLPAGETASLVSRCLAAHLHDPGLLTAGQREGDPDHYRQHILHVEDDGSFSVVALVWLPGQRTTIHDHVSWCVTGVYEGTESERRYRLVPDGDGTRLVATETVVNRVGDVCGFAPPGDIHLVRNACSSTAISLHIYGADVARLGSSVRRVYEPPADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF49</accession>
    <name>A0A2G1XF49_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_19675</name>
        <name evidence="8" type="ORF">CYQ11_11120</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49862">
        <property type="protein sequence ID" value="PHQ49862"/>
        <property type="gene ID" value="BLA24_19675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13362">
        <property type="protein sequence ID" value="PPT13362"/>
        <property type="gene ID" value="CYQ11_11120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="15412" checksum="74E3AE5C1C51A187" modified="2018-01-31" version="1">MLTITQALYDQIVAHARADHPDEACGVVAGPAGSGRPERFVPMLNAARSPTFYEFDSTDLLKLYREMDDRDEEPVVIYHSHTATEAYPSRTDVTYANEPGAHYVLVSTADTDGSGPFQFRSFRIVDGQITEEDVQVVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB5</accession>
    <name>A0A2G1XFB5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20055</name>
        <name evidence="5" type="ORF">CYQ11_10735</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49923">
        <property type="protein sequence ID" value="PHQ49923"/>
        <property type="gene ID" value="BLA24_20055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13301">
        <property type="protein sequence ID" value="PPT13301"/>
        <property type="gene ID" value="CYQ11_10735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="68" mass="7422" checksum="AFF26FA7D5E75489" modified="2018-01-31" version="1">MATGTVKWFNADKGFGFITQDDGGPDVFVHFSAIQATGFKSLEENMRVSYDVTQGPKGPQAENVVPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFL4</accession>
    <name>A0A2G1XFL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20090</name>
        <name evidence="2" type="ORF">CYQ11_10700</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49929">
        <property type="protein sequence ID" value="PHQ49929"/>
        <property type="gene ID" value="BLA24_20090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13295">
        <property type="protein sequence ID" value="PPT13295"/>
        <property type="gene ID" value="CYQ11_10700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="91" mass="10590" checksum="AB9CB3268B04A0DA" modified="2018-01-31" version="1">MLERRMSHDDLVDHLVRSTPLQRGEATRVVLDVLAYFDETAEEFVRRRHRELQSGGLNNAEIFERIAAELPHRAVAPPELSLRQLRRIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ7</accession>
    <name>A0A2G1XFQ7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">BLA24_20995</name>
        <name evidence="9" type="ORF">CYQ11_09790</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50076">
        <property type="protein sequence ID" value="PHQ50076"/>
        <property type="gene ID" value="BLA24_20995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13143">
        <property type="protein sequence ID" value="PPT13143"/>
        <property type="gene ID" value="CYQ11_09790"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="203" mass="22519" checksum="AAC213D44E950838" modified="2018-01-31" version="1">MGEQTGPVKRRLGVMGGTFDPIHHGHLVAASEVASQFHLDEVVFVPTGQPWQKSHKQVSPAEDRYLMTVIATASNPQFSVSRIDIDRGGPTYTTDTLRELRSLNENADLFFITGADALAQILTWRDTDELFSLAHFIGVTRPGHILANPGLPEDRVSFVEVPALAISSSDCRARVAQGEPVWYLVPDGVVRYIDKRRLYRHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG90</accession>
    <name>A0A2G1XG90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VCBS repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_22145</name>
        <name evidence="7" type="ORF">CYQ11_08640</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50258">
        <property type="protein sequence ID" value="PHQ50258"/>
        <property type="gene ID" value="BLA24_22145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12956">
        <property type="protein sequence ID" value="PPT12956"/>
        <property type="gene ID" value="CYQ11_08640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304672" evidence="4">
        <location>
            <begin position="34"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="80"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="489" mass="50699" checksum="22220319BB5DE6E0" modified="2018-01-31" version="1">MAENAYLRKSAIGIALVCAITGGTVATATAAFAAPAPAPAASATATPAADNDKGGAGQGPRTPAHPRSSLVAGATKLAPKITRSEAIKRAKSWVGIGLSYNQGGSYKGYRTDCSGYVSMAWNLSDSLATPEFGPEGVTEKISKNELKAGDALLNPKPGNYGHIVLFEKWANSDHSAYWGYEFTGSGVHYREIPYTYFSGYDAGSYYPVRNKSVVDDGPSDPGMTQLTAGDLNADGKKDVVAVKVETGELFLYPGTGKSGLDMLGDRVEIGSGGWNGMKNLTVGDFNGDGKDDLVASKTETGELFLYPGTGKKSLEALGDRVLIGTGGWNGMNNLSAGDFNGDGKADIIASKNETGELFLYPGTANKGLDTLGSRTLIGTGGWNGMNKLAAGDFNKDGKPDLVATKTETGELFLYPGTGKAGLDTLGDRTQIGTGGWNGISDYAAADFTGDGIADLAAVDSDRGETGKLYLYKGNGKGLDGRTEIGTGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGB9</accession>
    <name>A0A2G1XGB9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2277 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22305</name>
        <name evidence="2" type="ORF">CYQ11_08480</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50288">
        <property type="protein sequence ID" value="PHQ50288"/>
        <property type="gene ID" value="BLA24_22305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12926">
        <property type="protein sequence ID" value="PPT12926"/>
        <property type="gene ID" value="CYQ11_08480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="80" mass="8538" checksum="D69314FE6F083686" modified="2018-01-31" version="1">MCRSIKTLRPPVTPEPGEDDIRAAALQYVRKVSGFHAPAAHNREVFDEAVDAVAEATERLLAGLVVRGRRDAPTAGASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGK0</accession>
    <name>A0A2G1XGK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_22590</name>
        <name evidence="6" type="ORF">CYQ11_08200</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50335">
        <property type="protein sequence ID" value="PHQ50335"/>
        <property type="gene ID" value="BLA24_22590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12877">
        <property type="protein sequence ID" value="PPT12877"/>
        <property type="gene ID" value="CYQ11_08200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="207" mass="22839" checksum="66AB22E1EC98B03F" modified="2018-01-31" version="1">MAPPVVHSLRDQIREHILEGIVNGRWQPGERIVERRIAAELLVSQTPVREALRELESLRLIESAPNKGVRVRELTAADLKESYPVRAGLEQVAAELAADALAGDVSALEAEVAALRVADRAGDSEAQARHTVAFHRAIVRAAGNAVLLHTWESLGIEVWTALSIRWLSPQPRAHAEDHAEIVRAFERRDPKIGELLRTHVLSCAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGK2</accession>
    <name>A0A2G1XGK2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_22205</name>
        <name evidence="9" type="ORF">CYQ11_08580</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50269">
        <property type="protein sequence ID" value="PHQ50269"/>
        <property type="gene ID" value="BLA24_22205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12945">
        <property type="protein sequence ID" value="PPT12945"/>
        <property type="gene ID" value="CYQ11_08580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="34288" checksum="BF751A320A42AD9D" modified="2018-01-31" version="1">MFGNYLIGLREGLEASLVVCILVAYLVKTGRRDALRPVWLGIAVAVLLSMGFGALLQYGSQTMTFEAQEMLGGSLSVVAVGLVTWMVFWMRRTARHLKKELHGKLDAALAMGTTALVVTAFLAVGREGLETALFIWTAVQATDDGVRPLVGALLGLLTAVLLGWLFYRGALKINLAKFFTWTGGMLIVVAAGVLAYGFHDLQEADVLPGLGDRAFDVSEQIPVDSWYGTLLKGVFNFQPDPTWVQVGVWALYVVPTLVLFFAPGRAGRVSPSPAVTEESKRDETPVATSSVPGSGADGGGTADGDGLRDGARRTGGRPGGDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH25</accession>
    <name>A0A2G1XH25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19160</name>
        <name evidence="5" type="ORF">BLA24_19165</name>
        <name evidence="2" type="ORF">BLA24_22795</name>
        <name evidence="3" type="ORF">BLA24_22800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000153">
        <property type="protein sequence ID" value="PHQ49768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000153">
        <property type="protein sequence ID" value="PHQ49769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000150">
        <property type="protein sequence ID" value="PHQ50438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000150">
        <property type="protein sequence ID" value="PHQ50439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49768">
        <property type="protein sequence ID" value="PHQ49768"/>
        <property type="gene ID" value="BLA24_22795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49769">
        <property type="protein sequence ID" value="PHQ49769"/>
        <property type="gene ID" value="BLA24_22800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50438">
        <property type="protein sequence ID" value="PHQ50438"/>
        <property type="gene ID" value="BLA24_19160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50439">
        <property type="protein sequence ID" value="PHQ50439"/>
        <property type="gene ID" value="BLA24_19165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="90" mass="9430" checksum="7DEBBFA7A05703CC" modified="2018-01-31" version="1">MGRFKAGTGISTGCPSTTPVGLALGPDLPWADQLDPGTLSQSAHTFLTCVSLLMPAFSLVNRPQLASAAASPGTRRSPTHHSPRWGYILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHA2</accession>
    <name>A0A2G1XHA2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17595</name>
        <name evidence="4" type="ORF">CYQ11_15680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50612">
        <property type="protein sequence ID" value="PHQ50612"/>
        <property type="gene ID" value="BLA24_17595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14133">
        <property type="protein sequence ID" value="PPT14133"/>
        <property type="gene ID" value="CYQ11_15680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="12"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="283" mass="32621" checksum="C89964076483C4CD" modified="2018-01-31" version="1">MAVGRTGAELRGFREVQRLAYDCAEAVAAQLRPGVTEREAARMQREWLRGHGVRDWFHLPFAWFGDRTAFVGFRVPLQFFPTGRRLEPGMPFILDMAPVYRGFTADIGYSGCLGPDPLHDRLMADLQAHRDLILREVRERRPLREIYEDVARLMTRQGHTNRHRAYPFGVIAHKVDRVRERRWSPQVLGFGTQALKGLASDALRGHREGWSPLWSPHRFSDHPPHPGLWAVEPHLGFRGTGVKFEELLVVTDSRDPQESAFWLDDDLPHVRRPQQRQKEEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHB5</accession>
    <name>A0A2G1XHB5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17390</name>
        <name evidence="4" type="ORF">CYQ11_15885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50581">
        <property type="protein sequence ID" value="PHQ50581"/>
        <property type="gene ID" value="BLA24_17390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14164">
        <property type="protein sequence ID" value="PPT14164"/>
        <property type="gene ID" value="CYQ11_15885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304910" evidence="1">
        <location>
            <begin position="35"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="46"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="302" mass="31977" checksum="849A3A87842C10DE" modified="2018-01-31" version="1">MPRSNGTRVRSALTALGAAATLAAGVLAPASATAATPRSHGERYVALGDSFTSAPSVPRQTDTACGRSDANYPSLVREELGFGRFTDVSCAGAATEHLWQRQPVTGNAPQLAALGPDTALVTLGIGGNDVGFMDVLARCVHPTGEVPRDAPCQRAYTREGGGDELQRRIDDTAPKIAAALDAVHRRAPHARVAVVGYPTLIGDDVEGCRRSLRIADGDLPYLRGTVRNLNAMLRRQAVAHGDLYVNTHGTTFGHDACRPFADRWVEGLTTYPRIRPAAPFHPNEDGERAMAEAVVDALVDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHQ6</accession>
    <name>A0A2G1XHQ6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ORF">BLA24_18570</name>
        <name evidence="9" type="ORF">CYQ11_14710</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50778">
        <property type="protein sequence ID" value="PHQ50778"/>
        <property type="gene ID" value="BLA24_18570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13964">
        <property type="protein sequence ID" value="PPT13964"/>
        <property type="gene ID" value="CYQ11_14710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="62"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="306" mass="32814" checksum="5EA5DFB5CD84768B" modified="2018-01-31" version="1">MGDSTVGARSGGQEPERLPDGTAGTAGDGGAPVEDAHAGETETPGQDDGKVRRKQQRPLWKELPILIGVALILALLIKSFLVQAFSIPSDSMQNTLQRGDRVLVDKLTPWFGSKPQRGEVVVFHDPGGWLDEDTKQQNAVQKVLSFIGLMPSADEQDLIKRVIAVGGDTVECKGDNEPVVVNGKSLRESGHIFPGNTPCGDKPFGPITVPKGRIWVMGDHRQDSMDSRWHQNIDGGTVSEDEVVGRAIVVAWPLDRWSTLPVPGTFDQPGLNAAAAAAPPALGLAGALPLVLWRRRRLVGKAERQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIP5</accession>
    <name>A0A2G1XIP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_15140</name>
        <name evidence="10" type="ORF">CYQ11_12930</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51106">
        <property type="protein sequence ID" value="PHQ51106"/>
        <property type="gene ID" value="BLA24_15140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13670">
        <property type="protein sequence ID" value="PPT13670"/>
        <property type="gene ID" value="CYQ11_12930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="387" mass="42549" checksum="C0CE6FDA852FFBD0" modified="2018-01-31" version="1">MDFAFGPEDEAFRREARAWLTEHLTGQPVRTAGRAWERELGAGGWIGLGWHHARGTYGNRTTTLTGQIVWAEEYARAQAPPRHGHLGENLLAPTLLAHGDDAQCARFLPAVARGEELWCQGYSEPGAGSDLAAVRTTAVRSDGGRTYRISGQKIWTSLAHEADWCFVLARTAVGSQGHHGLSFLLVPMDQPGRIEVRPIRQMSGTADFNEVFFDGAEARAEHLVGGEGNGWRVAMGLLARERGVSTLVQQIGFAAELARVVRLAVENGAAGDPVVRDRLVRQWAELQTMRWNALRTLGTEAGPDAPSVAKLLWGGWHRRLGELAMQVRGEPAALGPGDWHADRPYRLDALQRLFLFSRADTIYGGSDEIQRTIIAERVLGLPKEHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIV4</accession>
    <name>A0A2G1XIV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15215</name>
        <name evidence="4" type="ORF">CYQ11_12855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51121">
        <property type="protein sequence ID" value="PHQ51121"/>
        <property type="gene ID" value="BLA24_15215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13657">
        <property type="protein sequence ID" value="PPT13657"/>
        <property type="gene ID" value="CYQ11_12855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="156" mass="16957" checksum="8FF5B1CB3BE178D1" modified="2018-01-31" version="1">MLMSPMMRGTTDNGLLLPVPDADGEPFWTYAARGELRIQSCADCGGLRFPPRPCCPRCQSFATEWRLMSGRGHIWSYVRPHPPLLPGYAEQAPYNVVLVQLADAPGIRLVGNPVSAPDAALDSVDPALLRVGAPVRAVFAEIAPGVTVPRWLLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ40</accession>
    <name>A0A2G1XJ40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_15970</name>
        <name evidence="12" type="ORF">CYQ11_12105</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51247">
        <property type="protein sequence ID" value="PHQ51247"/>
        <property type="gene ID" value="BLA24_15970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13528">
        <property type="protein sequence ID" value="PPT13528"/>
        <property type="gene ID" value="CYQ11_12105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304724" evidence="8">
        <location>
            <begin position="20"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="295"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="497"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="756"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="854" mass="87948" checksum="D7CE4503A5FB15BE" modified="2018-01-31" version="1">MTVLKTSLRNFLAHKGRMALSAVAVLLSVAFVCGTLVFTDTMNTTFDKLFSSTVSDVGVSPQKNDDAQQTGKPQTLPASLGGTLAKVPGVAEVEVHATNQQITVADGRNKSLSPASGAPTVGTNWNEGQKKSVEITSGHEPHGAGEVVLDSDTAAKHGVKQGDKLRVIATPGDFTVAVVGIATYKATNPGAAVFYFDTATAQTRLLGSADEYSGYGLTAAPGVSDEQLKKNVTAAIGTDYAVRTAAETKAENKKDIGSFLDVMKYALLGFAGIAVLVGVFLIVNTFSMLVAQRTREIGLMRAIGSSRKQVNRSVLAEALLLGVVGSVLGIGGGIALAVGLMELMGSMGMKLDTSDLTVKATTPVVGLAIGVVVTVLAAYLPARRAGKISPMAALRDAGNPADGRAGKVRAALGLLLTGAGGAALVAAATSDSAAAGSGMLGVGVLLTLVGFVVVGPLLAGYVVRAVSVVVLRLFGPVGRLAERNALRNPRRTGATGSALMIGLALVAALSVVGSSMVASATQQLDKSVGADFIIQAENDNALSPAVVKAVTSAGNVEHFTRYTHVVAKITTPDGRTATERLTAADPTYADDVRAETVQGKLADAYAKDAMAVPEGYAKDHGVRLGDRLTVAMTDGRTARLKVAAITSDDTSIDKGALYTGIATAASYLPADKMPLTGMILAKAADGRAKEAAASLKAAVADYPQIKVRDQADYKELIKGQVDQLLNMIYGLLALAIIVAVLGVVNTLALSVVERTREIGLLRAIGLSRRQTRRMIRLESVVIALFGALLGLGLGMAWGATSQKLLAMEGLGVLDIPWPTITAVFLGSAVVGLLAALVPAFRAGRMNVLNAIATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ80</accession>
    <name>A0A2G1XJ80_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">BLA24_16215</name>
        <name evidence="8" type="ORF">CYQ11_11860</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51287">
        <property type="protein sequence ID" value="PHQ51287"/>
        <property type="gene ID" value="BLA24_16215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13488">
        <property type="protein sequence ID" value="PPT13488"/>
        <property type="gene ID" value="CYQ11_11860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="114"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="386" mass="41609" checksum="D5D672247A7BDFA5" modified="2018-01-31" version="1">MCGYPGGVTFPVVGMVGGGQLARMTHEAGIPLGIRFKLLSDTPQDSAAQVVSDVVIGDYRDLDTLRAFAQGCDVITFDHEHVPTEHLRALEADGVPVRPGPDALVHAQDKGVMRAKLQEIGVPCPRHRIVADPADVVRFAEEGDGFPVVLKTVRGGYDGKGVWVVRDATEAAEPFRAGVPVLAEEKVDFVRELAANVVRSPHGQAVSYPVVESIQVDGVCDTVIAPAPDLSEELSAHAQQLALKVAKELGVVGHLAVELFETRDGRVLVNELAMRPHNSGHWTQDGAITSQFANHVRAVLDLPLGDPRPRAKWTVMANVLGGDYPDMYSAYLHCMARDPGLKIHMYGKDVKPGRKVGHVNTYGDDLADVRERAAHAAGYLRGTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJC3</accession>
    <name>A0A2G1XJC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16175</name>
        <name evidence="4" type="ORF">CYQ11_11900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51281">
        <property type="protein sequence ID" value="PHQ51281"/>
        <property type="gene ID" value="BLA24_16175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13494">
        <property type="protein sequence ID" value="PPT13494"/>
        <property type="gene ID" value="CYQ11_11900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="17208" checksum="C7D2202BC7BCDD30" modified="2018-01-31" version="1">MSTTRACPPPDGPGPEVEGGASAGLPPAGGGQARRLRLVGVSGAVPLSRDFTRQALRDWGWLPAATADHRAAAEDVLLVVSELVTNACLHADGPEELRVSQAGKTLRLEVSDLGAGTPAPRTPHRAGRPGGHGMFIVQRLCLDWGVQRREGETGKTVWAELAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK56</accession>
    <name>A0A2G1XK56_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase P60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12725</name>
        <name evidence="5" type="ORF">CYQ11_17080</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51561">
        <property type="protein sequence ID" value="PHQ51561"/>
        <property type="gene ID" value="BLA24_12725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14352">
        <property type="protein sequence ID" value="PPT14352"/>
        <property type="gene ID" value="CYQ11_17080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="197"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="339" mass="35689" checksum="0ADB7AB47BC4A0CC" modified="2018-01-31" version="1">MRKLWLGVGVGIVLCLGFVGLLVVGVYVAAGNLAGAGGKGTVGLAKGAVPDQYQALVTKWGNLCPALNPAVLAAQLYTESNWDPTALSPASAQGIAQFIPATWATEGIDGNGDGKRDVWDPADAIPSAASYDCQLSRDVKGVTGDITDNMLAAYNAGPYSVIQARGIPPYSETQGYVKSIRSLEKSFARPLTRVAPSQQAAGAIYFAQDKLGTPYLWGGEGGKEDNGRFDCSGLTQAAYRSVGIELPRVANDQWNAGPHPGRNELLPGDLVFFAHDLKDPRSIHHVGLYVGGGYMIHAPRTGAVIRFEKIDSQPDYIGATRVTANGAKALPRPVKANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKA5</accession>
    <name>A0A2G1XKA5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_11350</name>
        <name evidence="11" type="ORF">CYQ11_02585</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51684">
        <property type="protein sequence ID" value="PHQ51684"/>
        <property type="gene ID" value="BLA24_11350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11933">
        <property type="protein sequence ID" value="PPT11933"/>
        <property type="gene ID" value="CYQ11_02585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT11933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="551" mass="61077" checksum="9995235E7F1F3F14" modified="2018-01-31" version="1">MLFRRRKERTRQRVRAAALAGFTALDRRFPAAALGRQLLRKAFPDHWSYLLGELALYSLVVLVLTGCYLVLFFDPSMVETVYSGAYAPLRGQRMTQAYASTLDISFDVRGGLLIRQVHHWAALVFVAAIGAHMLRIFFTGAFRRPRELNWAVGVTLFLLALLEGFCGYSLPDDLLSGTGLRTANTIVMSIPVVGTYLSFLVWRGSFPGTAVIPRLYVVHVMFVPGVLLALVALHLFLVVYLKHTQWSGRGRTNRNVVGQPMFPQFTMKSTGLALMVSGALVVLGAVAQVNPVWAYGPYRADLVATGSQPDWYVGFLEGALRVMPPWQNAVAGHTLMWNVLLPAVVLPGLLFMILYTYPVFEKWVTGDRTEHHLCDRPRDRPTRTGLGVAAVVCYGLLLLAGGNDVIAYSFRLSVDGLTRVLRALVLLGPVVAFWVTKRLCLALQARDRRRLTEGEEDGQVEQSVYGGFGEGHQALSPEESYRLMVREAPAPLPAPEGPAPRRVRLRTALSSWYYRDRLEMPVTPEQRDQIAGRLAAPAVEPAEPATETEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKB0</accession>
    <name>A0A2G1XKB0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ptsP</name>
        <name evidence="20" type="ORF">BLA24_12420</name>
        <name evidence="21" type="ORF">CYQ11_04305</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="NHZO01000139">
        <property type="protein sequence ID" value="PHQ51667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51667">
        <property type="protein sequence ID" value="PHQ51667"/>
        <property type="gene ID" value="BLA24_12420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12223">
        <property type="protein sequence ID" value="PPT12223"/>
        <property type="gene ID" value="CYQ11_04305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="253"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="438"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PHQ51667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PPT12223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="556" mass="57318" checksum="E253B1E7F630A4AD" modified="2018-01-31" version="1">METTLRGVGVSHGVAIGEVRHMGTAVLEPPAKQIPADEAPREQGRARQAVEAVAADLIARGNLAGGEAQHVLEAQAMMAQDPELMADVERRITVGSTAERAVYDAFAAYRALLANAGEYLAGRVADLDDVRNRIVARLLGVPMPGVPDSDEPYVLIARDLAPADTALLDPTLVLGFVTEEGGPTSHSAILARALGVPAVVALPGAGELAEGTVVAVDGSTGDIFVDPSAEKRAELTKAAEARKAALAASSGPGATSDGHKVPLLANVGGPADVPAAVEAGAEGVGLFRTEFLFLDDSAKAPSEAKQVEAYRKVLEAFPEGRVVVRVLDAGADKPLDFLTPADEPNPALGVRGLRTLLDHPEVLRTQLTALAKAAAGLPVYLEVMAPMVADRTDAKAFADACREAGLRAKFGAMVEIPSAALRARSILQEVEFLSLGTNDLAQYTFAADRQVGAVSRLQDPWQPALLDLIAASAEAAKAEGKSCGVCGEAASDPLLACVLTGLGVTSLSMGAASIPYVRATLAKHTLAQCERAAAAARATDTAEEARLAAQAVLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKG7</accession>
    <name>A0A2G1XKG7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MepB domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12455</name>
        <name evidence="1" type="ORF">BLA24_28060</name>
        <name evidence="3" type="ORF">CYQ11_17580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48914">
        <property type="protein sequence ID" value="PHQ48914"/>
        <property type="gene ID" value="BLA24_28060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51639">
        <property type="protein sequence ID" value="PHQ51639"/>
        <property type="gene ID" value="BLA24_12455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14437">
        <property type="protein sequence ID" value="PPT14437"/>
        <property type="gene ID" value="CYQ11_17580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011235">
        <property type="entry name" value="MepB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038231">
        <property type="entry name" value="MepB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08877">
        <property type="entry name" value="MepB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19433" checksum="527B51CDEB7F7B0F" modified="2018-01-31" version="1">MVTNEPWAGLHGDLLAAKTAVYDPSRFVCSQPVPEPESAEYAAHAFTLDGLAVRFRVAKTTPTKVGQFVTVWQRSAEGPIRPFDAEDGVDLFVISSRDSGHFGQFVFPRAVLCERGIVSRGGSGGKRGFRVYPPWVTTTSRQAAATQAWQTAYFLHLGAEGGPLLDVVDVARAQALYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKP6</accession>
    <name>A0A2G1XKP6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12085</name>
        <name evidence="3" type="ORF">CYQ11_03325</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51813">
        <property type="protein sequence ID" value="PHQ51813"/>
        <property type="gene ID" value="BLA24_12085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12059">
        <property type="protein sequence ID" value="PPT12059"/>
        <property type="gene ID" value="CYQ11_03325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="8643" checksum="7C50B8ACD04ECE16" modified="2018-01-31" version="1">MLDSTTEQLAGDAKPDLDLANATWQSSGQGRRGNVQIAFVEGYIAMRDRRDPDVPAVIFSPGEWRAFVLSARDGAFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL07</accession>
    <name>A0A2G1XL07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10775</name>
        <name evidence="3" type="ORF">CYQ11_00775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51928">
        <property type="protein sequence ID" value="PHQ51928"/>
        <property type="gene ID" value="BLA24_10775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11627">
        <property type="protein sequence ID" value="PPT11627"/>
        <property type="gene ID" value="CYQ11_00775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="309" mass="31223" checksum="DDBBE8187435DE43" modified="2018-01-31" version="1">MRALTFSEYGPASVLEVAEVPEPHAGPGHIRVRVRASGLTPADCRLRSGRFRDMVPLRLPHVPGMDAAGVVDEVGTGVTGVWPGDEVFGIVDVAELGGANAEYAVLAAWALKPDALSWEQAGGAAGNVETATRALDRLKVDTGTTLLIEGAAGGVGTVAVQLAAARGATVIGTAGAHNHRFVAGLGATPITYGPGLGERITAVAPKGVDVVLDCAGSGSLPDLVDLAGSPNRVVTIADMNAAQYGVHHSRSAGPGADPQAVEGLAEAAALAGQGRFTVPVAATFPIENAAAAHQLIETGHTWGKIVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL12</accession>
    <name>A0A2G1XL12_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000129">
        <property type="protein sequence ID" value="PHQ51906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51906">
        <property type="protein sequence ID" value="PHQ51906"/>
        <property type="gene ID" value="BLA24_10980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="74" mass="7739" checksum="82CF9E44020BF1C8" modified="2018-01-31" version="1">MLYVTTFKNSSGLQFAMAGSALTLAGVIVLAPLLSRPFVNLCGRLAVRLAGVSGKLARENALRNPRRTAATAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL57</accession>
    <name>A0A2G1XL57_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_10675</name>
        <name evidence="5" type="ORF">CYQ11_00880</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51911">
        <property type="protein sequence ID" value="PHQ51911"/>
        <property type="gene ID" value="BLA24_10675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11644">
        <property type="protein sequence ID" value="PPT11644"/>
        <property type="gene ID" value="CYQ11_00880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304707" description="Ricin B-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="50"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="536"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="632" mass="69633" checksum="C7DEAC4B1EC7EEFE" modified="2018-01-31" version="1">MRLPLPPSRAKARSGPHRSRLTATFASALLAAGLLVGAAPGPGGSTARADERPAKTAASPNNGSLPFATYNMQGSDHGLRWGGEVGPLTMHHPVVALQEVGNGPPTAAHQRHGVGESIPIPGLFPAGLPDHVNHTVWRYRHHTRQVYYLQTDPQRDSTTGRDRWRGGRVNLAVVTQTRADEVRVIENPLYNRDEPRNEYRYRRALGVRIGNTVYYNVHARGADVAPLLRQIRAAARAGENWVMVGDFNLDIRNRTDRQAREQSLHLRPDEQLARTGRSTHQRGGELDYAITRGTPRFNADIPAGRGSDHYPVQFEPAPTPVPAAPDGPVHNFSSAFENARTGLALDVDNNNRVTTRLQAYNARQRFRVDTVRGHWYRFARGNSPRAASGALAGRAALAAGETCPGVNPFFPMSSILMLSCESPGAQWHSEDPGAPGGPLRWHNSLYPNLCLTGTKNEQPVVAFPCGDMPEQQWWDNSRAVPERAWEDSDAQVRLRAWNGLYLDNFGGSNRDGTPLTTRWPDNVKTQRWDIEYAGSGDNLVRLKGRGSGRCVDVLDSVQPRPGEPSVLHDCTGRGSKTDGTGHRWQAETFGDGTLRFRNEAAHLCLVPSARETGYVTIENCNDDARQRWTIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLC3</accession>
    <name>A0A2G1XLC3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_09840</name>
        <name evidence="5" type="ORF">CYQ11_04250</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000102">
        <property type="protein sequence ID" value="PHQ52043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52043">
        <property type="protein sequence ID" value="PHQ52043"/>
        <property type="gene ID" value="BLA24_09840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12216">
        <property type="protein sequence ID" value="PPT12216"/>
        <property type="gene ID" value="CYQ11_04250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="218"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="30730" checksum="BE9CBE47A62BF678" modified="2018-01-31" version="1">MSVDLGRCSDVQVGRCVQQGFVLPHGRVCSGQGESPVKLFAKLFGKSARQDGGTARHRASRPVDGGEGAQEGRPLFRDQVGAPEGDVPGGSGASSVDPAQAGRIGFGAPATSSAGGGFALPVCTRCGHRNAEASRFCSNCGAPLRPGAVAERASETTSTISISGLEAYDSEATGQTPIPTLSPEAQAAVDALPLGSALLVVRRGPNSGSRFLLDADVTTAGRHPQSDIFLDDVTVSRRHVEFRREQDGTFTVTDVGSLNGTYVNREQIESVALSNGDEVQIGKYRLVFFGSQRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLC7</accession>
    <name>A0A2G1XLC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_10005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000104">
        <property type="protein sequence ID" value="PHQ52030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52030">
        <property type="protein sequence ID" value="PHQ52030"/>
        <property type="gene ID" value="BLA24_10005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="87" mass="9827" checksum="622F63676757FC2E" modified="2018-01-31" version="1">MERFDMAVKLHTDAYIRSRAMSRTKLAALHMAIGDPREAVTVGTLALEYVGQMRSQRAADGLRELPTLGYQHRATPERAVREVMPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLK1</accession>
    <name>A0A2G1XLK1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09505</name>
        <name evidence="4" type="ORF">CYQ11_28115</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52144">
        <property type="protein sequence ID" value="PHQ52144"/>
        <property type="gene ID" value="BLA24_09505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16225">
        <property type="protein sequence ID" value="PPT16225"/>
        <property type="gene ID" value="CYQ11_28115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="119" mass="12730" checksum="62D3FA69674CB5BF" modified="2018-01-31" version="1">MSDMPVVRSGPDRGERSMEPVYDLMARLLTEYFGVPEEEITPDATYEQLEIDSLAQAEMVTLLEDHLRMTLDQELRGETLGEAAAHVERLLAGRAGPAEAAAGHDAGAAGPAALTVPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM7</accession>
    <name>A0A2G1XLM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09405</name>
        <name evidence="4" type="ORF">CYQ11_28015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52127">
        <property type="protein sequence ID" value="PHQ52127"/>
        <property type="gene ID" value="BLA24_09405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16207">
        <property type="protein sequence ID" value="PPT16207"/>
        <property type="gene ID" value="CYQ11_28015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="94"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="30594" checksum="03C64180D74B9E20" modified="2018-01-31" version="1">MACSAFAVTAMDDDQLECQPAGAAANAGRAQEAECQARTPAHRSAAKPAGKAGGHHGGGDGVPHGGGPPPAPPPGVPQEAEGVYDHERCGNTSGRVLLTLDDWAYSDPERPVRIGAQLQAQGVRAAFFLINKYAAQYPQVASTLRQQGHWVGNHTVSHRHLPSLTDEESKDEIRGGVTGNLLRPPYGDFGEREKEIAAEAGMRICNWTIDTHDWEKTQGNARSADDIRASVRDATPEEKHNGVVLGHLFSNYPEALAGIITDLQAQGYQMCRNTGPVGEQVPNPLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLP5</accession>
    <name>A0A2G1XLP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09525</name>
        <name evidence="6" type="ORF">CYQ11_28135</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52147">
        <property type="protein sequence ID" value="PHQ52147"/>
        <property type="gene ID" value="BLA24_09525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16228">
        <property type="protein sequence ID" value="PPT16228"/>
        <property type="gene ID" value="CYQ11_28135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="217" mass="23060" checksum="2290062A630A1113" modified="2018-01-31" version="1">MIRVLIADDEPLIRAGIRMILTSADDIEVVAEAANGREAVDLARKHRVDVALLDIQMPVLDGLTTLAELGRTAPGLRTLILTTFGERENVLRALREGGAGFLLKDSAPAELIGAVRAAAQGDAYLSPAATRHVVESLAAGAGPSRGEEAQRRLAALSEREREVLALLGEGLSNAETGRRLHMSEATVKTYVSRILAKLECENRVQAALLARDAGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR3</accession>
    <name>A0A2G1XLR3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09565</name>
        <name evidence="4" type="ORF">CYQ11_28175</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52182">
        <property type="protein sequence ID" value="PHQ52182"/>
        <property type="gene ID" value="BLA24_09565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16848">
        <property type="protein sequence ID" value="PPT16848"/>
        <property type="gene ID" value="CYQ11_28175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="164"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="370" mass="38786" checksum="07184A52DCB362B2" modified="2018-01-31" version="1">MANTGLGLAFAVTLAVFARQIAREDREWLFGFCVSLVVCAAALVRERHRVGAAVVGIVVAGGAGVVAKVADLPREPGAASALALLVLGGSAVRALPLRAAAAVAVGGVAAMAVDWLSIDPESGVWQGPFQLGAVGWAVALGVGAWLRWLDYRRHAATEAVRREERLALARELHDIVAHHVTGIVLQTQAAKIVSRSRPEALDETLTGIEQAGTDALTAMRRVVGLLRDTDDGAGTTPGPEGLTELVRRFEGHGHGPAVRLNLPEEKAAWSPEVTTTVYRIVQEALTNIARHAPHARTATVDVLHAPDGITVEITDDAPPAPARYPHRGGFGLIGMRERVETLGGTLRAGPGSEAGWSIHATLPVAAGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLZ6</accession>
    <name>A0A2G1XLZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09590</name>
        <name evidence="3" type="ORF">CYQ11_28200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52159">
        <property type="protein sequence ID" value="PHQ52159"/>
        <property type="gene ID" value="BLA24_09590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16240">
        <property type="protein sequence ID" value="PPT16240"/>
        <property type="gene ID" value="CYQ11_28200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="28735" checksum="3D15E2F9DD888211" modified="2018-01-31" version="1">MQQVFTNGIRISYSRSGGGKPVLLVMGSSSPGRVWTTHQTPALARAGYESVTFDNRGVPPSDAPPGKYTLDDMVADTKGLIDALDLAPCRIVGTSLGSMIAQELAIQSPGSVRCAVLLGTRGRADEFRRAEVTAQRALIESGVRMPPAYEAFVSVLQMLSPATRNDEEKVERWLDLFELSAPGHTAAGQAWADIVSDRREELRKVSAPCRVISFTDDVITPPALCAEVADAIPDCDLVEIPSCGHLGYLERPQEVNASIIEFLDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM01</accession>
    <name>A0A2G1XM01_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08830</name>
        <name evidence="4" type="ORF">CYQ11_04090</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52253">
        <property type="protein sequence ID" value="PHQ52253"/>
        <property type="gene ID" value="BLA24_08830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12186">
        <property type="protein sequence ID" value="PPT12186"/>
        <property type="gene ID" value="CYQ11_04090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="22449" checksum="D5B201355E233D9C" modified="2018-01-31" version="1">MTAEHPGSTANASGPSGASRASRLELIADSAIALLAERGMRGLTHRAVDEAAGLPPGSTSNHARTRAALLELAVRRHAAREARVLTPDEMPDPAGGFDALAEALAIVLHRSLTGHRELLLARYELALEATRRPELRKIYDEEGRAFREPLVALMTAGGSTDPQRHALSLVAWCEGLMFSCAAGSYHAETPSRAQLRTGFTELLRGMLGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM19</accession>
    <name>A0A2G1XM19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_08625</name>
        <name evidence="7" type="ORF">CYQ11_03880</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52221">
        <property type="protein sequence ID" value="PHQ52221"/>
        <property type="gene ID" value="BLA24_08625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12154">
        <property type="protein sequence ID" value="PPT12154"/>
        <property type="gene ID" value="CYQ11_03880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="355" mass="37602" checksum="02270017A64CA56A" modified="2018-01-31" version="1">MADTAPPSGPAGTPRSGRPRYGARPTMKDVASRAGVGLKTVSRVVNGEPGVTPDTERRVQDAITALGFRRNDSARILRKGRTASIGLILEDLADPFYAPLNRAVEEVARDHGALLINGSSAEDADREQELALAFCARRVDGLIVIPAGHDHRYLEPEIAAGVATVFVDRPAGLIDADAVLTDNFGGAREGVAHLVAHGHRRIGFIGDQPHIHTAAERLRGYRAAMETAGLPVDGSWVSPGSTAPGRVRAEAERMLTGPDPVTALFTGNNRVTVTAVRVIAELGRPVALVGFDDFELADLLSPAVTVVAQDPARLGRTAARLLFRRLEGVEGAPRRVELPTRLVPRGSGELPPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMC1</accession>
    <name>A0A2G1XMC1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TnsA-like heteromeric transposase endonuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07590</name>
        <name evidence="3" type="ORF">CYQ11_00020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52321">
        <property type="protein sequence ID" value="PHQ52321"/>
        <property type="gene ID" value="BLA24_07590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11524">
        <property type="protein sequence ID" value="PPT11524"/>
        <property type="gene ID" value="CYQ11_00020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="33969" checksum="2956CF70E07EB401" modified="2018-01-31" version="1">MRHGIAAAVHPFGGRIRITAFSSPSWTWLLSVEGHEHSRRVQQAAAGGDGAGIEAAFVTAAERLTQLPWDQAAASVRFEDVAPVSAFPVVPGRRWGPGWWWSATTGRHVVHGSAVMRTQLMVLDRNPDVTGLAARPVRLLWRDTDGRVRSWVPQLFARYADGTGLLADCPSSPAVGGDGAQRARMVLEAACARVGWSYRRLEPPPPVVAANLRWLAGYRHPRYQGPPGLRAALAEAFVGLRPLADGAAAVGDPLQVLPAVYHALWCGHLTTPLDEPLHEETLVCADAERGGRGASKSVWAPGGGRGRGERSGRHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMD8</accession>
    <name>A0A2G1XMD8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07710</name>
        <name evidence="3" type="ORF">CYQ11_00140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52412">
        <property type="protein sequence ID" value="PHQ52412"/>
        <property type="gene ID" value="BLA24_07710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16256">
        <property type="protein sequence ID" value="PPT16256"/>
        <property type="gene ID" value="CYQ11_00140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="173" mass="19194" checksum="803E84064771D14F" modified="2018-01-31" version="1">MDWLPLLSTLAGAAIGIVATLIADRNRWKHEDVKEAVRLRLDIYTQYTTTVKVLGETLRALAERERPSDGERALALREAFRNSGIATASERMWLIAPQPVVKASNSVFHCLRRICDGYVDGAAVSSPEDRARWEARGKAAAKMRKLMREDLGVGPLTERHSSLLNDDNNPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMH8</accession>
    <name>A0A2G1XMH8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07670</name>
        <name evidence="2" type="ORF">CYQ11_00100</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52410">
        <property type="protein sequence ID" value="PHQ52410"/>
        <property type="gene ID" value="BLA24_07670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16254">
        <property type="protein sequence ID" value="PPT16254"/>
        <property type="gene ID" value="CYQ11_00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17950" checksum="0C74DBEFCDB94B16" modified="2018-01-31" version="1">MPDLLWDDVRNFFDPDLMGSLPDARVADTSVEDWQAVLDLVRSQGWSCEYSEDGVAVRLPRAADMLVRSESADALLRVWPATGFLVIFRAYEAGSIDFDVNLRELRGQDGVDLLCRLLRAVRRRLGKPVMLTPESDPLHPVLGFDVEADRVVPLADPHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMI6</accession>
    <name>A0A2G1XMI6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="13" type="ORF">BLA24_06635</name>
        <name evidence="14" type="ORF">CYQ11_26785</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52457">
        <property type="protein sequence ID" value="PHQ52457"/>
        <property type="gene ID" value="BLA24_06635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15989">
        <property type="protein sequence ID" value="PPT15989"/>
        <property type="gene ID" value="CYQ11_26785"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="12"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="227"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ52457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="30638" checksum="844C608BD189CC4A" modified="2018-01-31" version="1">MTDDATGARTYDVLVIGSANADLTVRVDRRPGPGETVLGTDLVENAGGKGANQAAAAARLGARTALLAKVGDDAFGEMVLDGQREAGTELRHVLVERGARTGTAMIVVGPDGDNAIVVSPGANSRLLPGDVTDARAAVAASAVVSLQLEIPPETVRAAVAVAGETGTRVVLNPSPVPEVLDPALLEAADPLVVNEHEARGLSGLDAGTAADWARALRARGARSVVVTLGAQGALALDDAAGDPVAVPGVAVTAVDTTGAGDAFTGALATRLAAGADLADAARFAVRVGAVSVTRAGAQPSYPTAEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMY3</accession>
    <name>A0A2G1XMY3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_07415</name>
        <name evidence="5" type="ORF">CYQ11_27565</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52588">
        <property type="protein sequence ID" value="PHQ52588"/>
        <property type="gene ID" value="BLA24_07415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16125">
        <property type="protein sequence ID" value="PPT16125"/>
        <property type="gene ID" value="CYQ11_27565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="23639" checksum="93AAEE1D8161120C" modified="2018-01-31" version="1">MHIQEWLETVPAIAVYLLVGGVIGLESLGIPLPGEIVLVSATLLAATQDHINPYVLGACAITGAVVGDSIGYLIGRKGGKPLLAWLGRKFPKHFGPHHVATAERSFQKWGMWAVFVGRFIALLRIFAGPLAGVLRMPYWKFLIANVLGGIVWAGGTVAVIYSVGKVAEEWLKKFSWLGLVAALLFGLGSFVVMRIKAKKAAAAQDAEEKAARPENEAVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNB6</accession>
    <name>A0A2G1XNB6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_05585</name>
        <name evidence="7" type="ORF">CYQ11_02045</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52742">
        <property type="protein sequence ID" value="PHQ52742"/>
        <property type="gene ID" value="BLA24_05585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11838">
        <property type="protein sequence ID" value="PPT11838"/>
        <property type="gene ID" value="CYQ11_02045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="9"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="302" mass="30241" checksum="B4E837DD629DA98D" modified="2018-01-31" version="1">MTGAGPGALLVVGDVVTDVVARHRAPLAPATDTAARITVLPGGAGANVACWAARCGVWDVRLLARVGADAVDRHEHALRAAGVRPHLVTDPEASTGTVISLVGADGERTFLTDSGAVLRLSAADWSDDLLAGAGHLHVSGYLFFDGTSRTAVRRAVEAARARSVPVSVDPASAGFIARFGVDRFLAAVAGADVLLPNHDEAALLTGLPEPADAAAELSRLFPLVVSTVGSRGALVAASGTVVARVPAEPATAVDTTGAGDAFTGAFLAARLAGRDPATAARQGCRAGAQAVAVVGARPPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XND2</accession>
    <name>A0A2G1XND2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05465</name>
        <name evidence="4" type="ORF">CYQ11_01925</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52723">
        <property type="protein sequence ID" value="PHQ52723"/>
        <property type="gene ID" value="BLA24_05465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11817">
        <property type="protein sequence ID" value="PPT11817"/>
        <property type="gene ID" value="CYQ11_01925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20927" checksum="56335AEA784E19E4" modified="2018-01-31" version="1">MYTAWVNTSERLIESTRELLWERGYVGTSPKAIQQRAGAGQGSMYHHFAGKHELALTAIRRTADDMRARAEEQLSAPGTALERLTAYLLRERDVLKGCPIGRLTQDPDVMADPVLRAPVDETFVWLRGRLADILAEGRDRGELDAALDPAGTASAVVAVLQGGYVLARAADSAELFHTAVTGVLALLSSRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XND7</accession>
    <name>A0A2G1XND7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05715</name>
        <name evidence="3" type="ORF">CYQ11_02190</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52762">
        <property type="protein sequence ID" value="PHQ52762"/>
        <property type="gene ID" value="BLA24_05715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11863">
        <property type="protein sequence ID" value="PPT11863"/>
        <property type="gene ID" value="CYQ11_02190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="169" mass="17952" checksum="67A47B7BDBF20AFC" modified="2018-01-31" version="1">MTTLSIVRGDITEQQADAIVNAANSSLLGGGGVDGAIHRAGGSEILEACRALRASHYGKGLRTGAAVATPAGRLQADWVIHTVGPVYGADEDRSELLASCYRESLRVADELGAKTVAFPAISTGVYRWPMEDAARIAIETVRQTPTSVEEVRFVLFDERAYEAFAARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNL1</accession>
    <name>A0A2G1XNL1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05495</name>
        <name evidence="3" type="ORF">CYQ11_01955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52729">
        <property type="protein sequence ID" value="PHQ52729"/>
        <property type="gene ID" value="BLA24_05495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11823">
        <property type="protein sequence ID" value="PPT11823"/>
        <property type="gene ID" value="CYQ11_01955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="118"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="31823" checksum="9557C61B8DDB1BF8" modified="2018-01-31" version="1">MPLALLRRFKSSPRQGGAPIPQGAGVVDCLVLDPLRLPMHRAEVSVRDAAGREVVHGQSDPHGRFAATVPPGEYGLVVTAEGFQPVRRSFVCVEQTRTTLDAIGMETAPTPATPAAGVWRVDPDHTAVRFIARHIGLAEVHGRFNRFQGTLWVGERMEHSRLDVVIETASIDTGVERRDEHLCSPEFLDVATYPYMRFTSERFVHRGGSRWSVEGVLNLHGISRNVALDTRYLGIGTGIAGETRAACSAGTELHREDFTLNWRSMLQRGIVMIGTTIRVELDIQAVPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN0</accession>
    <name>A0A2G1XNN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nitrite reductase (NAD(P)H) small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nirD</name>
        <name evidence="12" type="ORF">BLA24_04670</name>
        <name evidence="13" type="ORF">CYQ11_28860</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="PPT11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52865">
        <property type="protein sequence ID" value="PHQ52865"/>
        <property type="gene ID" value="BLA24_04670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11475">
        <property type="protein sequence ID" value="PPT11475"/>
        <property type="gene ID" value="CYQ11_28860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="228"/>
            <end position="247"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="253"/>
            <end position="277"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="11">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ52865.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PPT11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="574" mass="60057" checksum="AA01E4884EC98671" modified="2018-01-31" version="1">MNETALSPHRSPRPDPDALVEIGDGTTWTTVCRYGDLTPGRGVTALVGGEQVALFRDPAGALYALANRDPFSDACVISRGIMGSRDGTPAVTSPMYKQTFDLRTGACLDEETAPDGSPAALRAWAVRTTEPAPPARGRTLPEWRPEDPAFWEATGARVARRNLWLSVLTEHIGFSVWSMWSVLVLFLGPEYGIDPAGKFTLTAVPTALGAVLRVPYTYAVARFGGRNWTVFSGLLLLVPTAYIALVLQPGVSYTTLLTAAAVAGVGGGNFASSMANINAFYPQRLKGRALGVNAGGGNLGVPAVQLAGLLVLATAGAGHPRLLPLAYVPLIALTALVAALRMDNLPAGHHERPAMGEVLGDRHAWALSLLYLGTFGSFVGFAFAFGQVLQVQFHDEFDTPVKAACLTFLGPLLGSLSRPLGGAWADRLGGGRVTTAVFLAMAGCAGLILVAAQHRLLAGFFAGFLTLFVLSGVGNGSTYRMIPALYAARARAAVRGGADARTAEAAAHRRTTAMIGLAGAFGTFGGVLVNVAFRQSFLTAGNGDAAYAAFLVFYLACAALTVVLCRRGRAAAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW5</accession>
    <name>A0A2G1XNW5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional 3'-5' exonuclease/DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05125</name>
        <name evidence="4" type="ORF">CYQ11_28405</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52934">
        <property type="protein sequence ID" value="PHQ52934"/>
        <property type="gene ID" value="BLA24_05125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11405">
        <property type="protein sequence ID" value="PPT11405"/>
        <property type="gene ID" value="CYQ11_28405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="2">
        <location>
            <begin position="314"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="556" mass="60247" checksum="883E5068086D16A2" modified="2018-01-31" version="1">MKWAVSGGRGGEGVRLCPLDGAGRAAGPVVTERSLAEAVRSRPEAERWVWRSTARTYGALLEAGVRVDRCYDVEAAEALLIGHEEGQSGQPRSLAAAWARLRGLPVPADPPVRAAETQPSLFEPGPVPLPPGADELDVLLEVYAHQQSRIERAGHPGRLRLLTAAESAGMLVAAEMGRAGVPWRADVHRDLLTTLLGERYPGGQETRRLAELAEEVSQAFGERVRPDLPADIVRAFARRGVALSSTRAWELRTLDHPAVPPLLEYKKLYRLHTAHGWSWLQSWVRDGRFHPEYLPGGTVSGRWTTNGGGALQIPKVIRRAVVADPGWRLVVADADQMEPRVLAAISRDPGLMDVAGSGRDLYADLAERAFSGDRERAKLAMLGAIYGQTSGDGLKHLADLRRRFPRAVAYVDDAARAGEEGRLVRTWLGRTCPPSSTAVDDEAGIPQEEEPAGYGSTAGARARGRFTRNFVVQGSAADWALILLATLRQFLAGLRAELVFFQHDEVIVHCPREEAGAVVEAVRSAGDRAGRIAFGDTPVRFPLTTAAVECYAEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNZ7</accession>
    <name>A0A2G1XNZ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05205</name>
        <name evidence="4" type="ORF">CYQ11_28325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52946">
        <property type="protein sequence ID" value="PHQ52946"/>
        <property type="gene ID" value="BLA24_05205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11392">
        <property type="protein sequence ID" value="PPT11392"/>
        <property type="gene ID" value="CYQ11_28325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="138" mass="14874" checksum="8B6EBB16994E49E1" modified="2018-01-31" version="1">MDCIFCAIAAGATAAHLVLEDETAVAFLDARPLFPGHVLVVPRRHAETLTDLPAGDLGPFFTRVQRVAGAVERAMDAAGSFVAANNRVSQSVPHFHVHVVPRNRKDGLRGFFWPRTRYGSDEEAAAVAARLRAALGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP27</accession>
    <name>A0A2G1XP27_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05195</name>
        <name evidence="3" type="ORF">CYQ11_28335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52987">
        <property type="protein sequence ID" value="PHQ52987"/>
        <property type="gene ID" value="BLA24_05195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11501">
        <property type="protein sequence ID" value="PPT11501"/>
        <property type="gene ID" value="CYQ11_28335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="107" mass="12151" checksum="37C8394C9904D325" modified="2018-01-31" version="1">MPRGSSPKRERQYEYIKDSVRDRGESEKRAKEIASRTVNKERARAGESKTASRTSLDDMSSSRRGGQRSHSGAQGPTKEQLYNEARQKNIHGRSDMTKEELKKALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP73</accession>
    <name>A0A2G1XP73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04130</name>
        <name evidence="3" type="ORF">CYQ11_14130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53013">
        <property type="protein sequence ID" value="PHQ53013"/>
        <property type="gene ID" value="BLA24_04130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13879">
        <property type="protein sequence ID" value="PPT13879"/>
        <property type="gene ID" value="CYQ11_14130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="311" mass="32618" checksum="2518D9E63A4A7425" modified="2018-01-31" version="1">MTAPSKPARPAAPSWTIGLVTPPDAHDAPAPRVIAPEVSGPPTRQALRAHLLAARLAGAVATPRERSLVRYRLFAARDPRVTLGLEPESDWRFADLLRLMGQKCGVSADPKDTSGQDVIDPDRTLAALDAFADRLATVAATGAPVLFGTGHPGPLLGFYAALAEGLSAGGCGVLTPAQGRSVDITTRFGVRHYNLDYVRGVAMVREPGARDHRSEPGAHTHSPLPVRVALAAAAEAGEGLPALVVGDHGWVCGAGQLGIEAIGLADSDDPSLFVGEAEGRVSVVVPLDDTVRSDYYRPLTRYVLNRACLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPD8</accession>
    <name>A0A2G1XPD8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_03775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000052">
        <property type="protein sequence ID" value="PHQ53086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53086">
        <property type="protein sequence ID" value="PHQ53086"/>
        <property type="gene ID" value="BLA24_03775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="176" mass="18352" checksum="2DA1E44AA86FFF6C" modified="2018-01-31" version="1">MEEVESTLRKAPGVTDAGAYADREEGETRIVACVTAGEELDVPALRAHLRDRLPTTCCPPASSRCPACRSAPTASSTARPCATSWRAPGPDGGDFAPADATEAAVAALWRELLGAPPATADENFFDAGGHSLLAVRLAGRLEATAGRRVPLRRILGAPTVRGIAAVCHEVRKEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPG9</accession>
    <name>A0A2G1XPG9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_03320</name>
        <name evidence="5" type="ORF">CYQ11_16970</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53113">
        <property type="protein sequence ID" value="PHQ53113"/>
        <property type="gene ID" value="BLA24_03320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14335">
        <property type="protein sequence ID" value="PPT14335"/>
        <property type="gene ID" value="CYQ11_16970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="23509" checksum="89DF73981657D692" modified="2018-01-31" version="1">MTGTPEKPDGRQKAEGPPAAGGTPPAPRRRGRPSRTAAGSGPGARERILTAARAEFAEHGYDGASIRGMAKNAGVDPALVHHYFGPKEKIFAAAVETAFAPALSVADLVIDAGPEGAGERMARFVLGVWEDPVTREPLLAILRSAVANETAAGVFRDLVSSRLMIRLAAELDGPDARLRSELAASHLVGVAMLRHVIKLEPLASADVEQVVAMVGPAVQRYLTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPR3</accession>
    <name>A0A2G1XPR3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">coaBC</name>
        <name evidence="7" type="ORF">BLA24_02685</name>
        <name evidence="8" type="ORF">CYQ11_04980</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53237">
        <property type="protein sequence ID" value="PHQ53237"/>
        <property type="gene ID" value="BLA24_02685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12330">
        <property type="protein sequence ID" value="PPT12330"/>
        <property type="gene ID" value="CYQ11_04980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="195"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="200"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="410" mass="43086" checksum="28F723DBD6ED9580" modified="2018-01-31" version="1">MDKPKVVLGVSGGIAAYKACELLRRLTESGHDVRVVPTASALQFVGEATWSALSGHPAATEVWESVHEVPHVRIGQQADLVIVAPATADMLAKAAHGLADDLLTNTLLTARCPVVFAPAMHTEMWENPATQENVATLRRRGAVVIEPAVGRLTGVDTGKGRFPDPAELFEVCRRVLARGARPADADLAGRPVADLAGRHVVISAGGTREPLDPVRFLGNRSSGKQGYALARTAVARGARVTLVAANSELADPAGADVVRVGTAVQLREAVLKAAADADAVVMAAAVADFRPAHYATGKIKKRDGQEPDPIALVRNPDILAELSADRPHPGQIVVGFAAETDDVLANGRAKLARKGCDLLVVNEVGERKTFGSEENEAVILATDGAETIIPHGPKEDLADTVWDLVATRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPR5</accession>
    <name>A0A2G1XPR5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02425</name>
        <name evidence="6" type="ORF">CYQ11_04790</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53210">
        <property type="protein sequence ID" value="PHQ53210"/>
        <property type="gene ID" value="BLA24_02425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12302">
        <property type="protein sequence ID" value="PPT12302"/>
        <property type="gene ID" value="CYQ11_04790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="16695" checksum="D1C31B1B411AE950" modified="2018-01-31" version="1">MRLNELDERIVHALAEDARRSYADIGAEVGLSAPAVKRRVDRLRAEGAITGFTVRVDPAALGWETEGFIELYCRRNTSPEAIHRGLSRYPEVASASTVTGEADAIVQIFASDMRHFERVLERIAGEPFVERTKSVLVLSPLLRRFSSGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPS7</accession>
    <name>A0A2G1XPS7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02585</name>
        <name evidence="3" type="ORF">CYQ11_04880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53220">
        <property type="protein sequence ID" value="PHQ53220"/>
        <property type="gene ID" value="BLA24_02585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12312">
        <property type="protein sequence ID" value="PPT12312"/>
        <property type="gene ID" value="CYQ11_04880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="283"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="409" mass="44341" checksum="4FAD3AD893C3F417" modified="2018-01-31" version="1">MKTVIIGAGVSGVASALALSREHEVTVYEQADELRADGNGVLLYPNATGLLRTWGIRLDDLGVRVEALDLLSEYGETLLQMDMAAIARRYRHPVIVGKRGGVLAALAERLPAGTVQFGKQLTGIKYRTDRPRTTVVASFSDGSEVECDALIGADGHRSAVREHLLGHDPAAYCGDATWHGITALPHGFSEGDRIHSLYSHEGICVMHPVGDGQVYWAFELPWREGDTAPPGKPGGHGFGHPGVPVEGSPVENLRARFGHWTGGALPQLLETITDDDISVFPHIMHHVRPYWGDGPVTLAGDAAHVVPPRLGMGLCQALEDAWVLERAMSGPGTANERLRAYEGARWPRLRRMRTIAEVMGRRTLPAPPKLAQRIGRFVPMTAYQQLQVKRLSNYLNDDAPGTGASVHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ08</accession>
    <name>A0A2G1XQ08_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DUF1211 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_03200</name>
        <name evidence="14" type="ORF">CYQ11_05500</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53324">
        <property type="protein sequence ID" value="PHQ53324"/>
        <property type="gene ID" value="BLA24_03200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12421">
        <property type="protein sequence ID" value="PPT12421"/>
        <property type="gene ID" value="CYQ11_05500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="22602" checksum="E284E38CD2A7EBFA" modified="2018-01-31" version="1">MSEAPQGAGEAARSPAGHLVPKHRMLALTDGVTAIAMTLLVLDIELPSGLRGAELDRALGEVPSQVGTFLLSALVIALFWRAHHAALESAERIDVRLFWLNVAFLALVSLIPFPTSVLQNYGDRTLGPGLYGAVIGTVSLVVYAMEVHAHRLSAAPRRRPVPFPAQALVFLLSIGIAHISPLAAIYSWAAALPLSVLADKVAARRAGPGAGAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ44</accession>
    <name>A0A2G1XQ44_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01680</name>
        <name evidence="3" type="ORF">BLA24_01685</name>
        <name evidence="1" type="ORF">BLA24_25735</name>
        <name evidence="4" type="ORF">CYQ11_20335</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000029">
        <property type="protein sequence ID" value="PHQ53365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000029">
        <property type="protein sequence ID" value="PHQ53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49445">
        <property type="protein sequence ID" value="PHQ49445"/>
        <property type="gene ID" value="BLA24_25735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53365">
        <property type="protein sequence ID" value="PHQ53365"/>
        <property type="gene ID" value="BLA24_01680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53366">
        <property type="protein sequence ID" value="PHQ53366"/>
        <property type="gene ID" value="BLA24_01685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14905">
        <property type="protein sequence ID" value="PPT14905"/>
        <property type="gene ID" value="CYQ11_20335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="156" mass="17480" checksum="35E85E223915EB3D" modified="2018-01-31" version="1">MTSTTTYRIGHPVVLDELPAGTEIRDADGDTGTKVQDGAWKVIGFPVALDPDWFRFPVEVVNPTPETALLVADFAGLHRLPDLMAELRSVVADIRTLRTSQEDKLDELRDENGDVPSGNLRRWDELRYDIHVEQDSDKLAAVLRRLEQLVDTEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQC8</accession>
    <name>A0A2G1XQC8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_00360</name>
        <name evidence="7" type="ORF">CYQ11_07370</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53423">
        <property type="protein sequence ID" value="PHQ53423"/>
        <property type="gene ID" value="BLA24_00360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12727">
        <property type="protein sequence ID" value="PPT12727"/>
        <property type="gene ID" value="CYQ11_07370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_3" evidence="5">
        <location>
            <begin position="54"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_101" evidence="2">
        <location>
            <begin position="295"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_101C" evidence="3">
        <location>
            <begin position="573"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="GalBD_like" evidence="4">
        <location>
            <begin position="877"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114767" checksum="82D5F2B10699328B" modified="2018-01-31" version="1">MTADRREARPGPTPRTGPSRRTAVVTTALAGLGTALAPATAAARTARTPAEAVLRSAALDVRVDTAFPRILSYTDRATGAVLYGQEEPVTTLLIDGTTHTPHVTATTTADRATYTLTLPTGTRIDAEIHVDGWRVDWRVTRIADAPGPPRRVGTLQIPGLAFLAVRDTQPGATLLAARIALDAAGNGDTLVRVTPATPPDPAPLGCAYAVVSTDRLAAAIETNTVQDRPDARTAWENGRLWRQTLARPGHTEARITAGQWTHRAATAPADDTAPLPRVSVILTRDRNGDGRTDWQDAAIALREIMTDPPGADEQHLRVVPHIPFNFASQATNPFLTTLDNIKRIHLATDGLRQFTLLKGYQSEGHDSAHPDYGGNYNTRAGGLADLNTLLRAGKKWNSDFAVHVNTTESYPVAHAFSETLVDENDPQWDWLDQSYRIDPRRDLVSGDLARRFRQLREETDPALTTLYIDVFRESGWNSDRLQRLLREQGWQITTEWGHGLERSSLWSHWATETDYGPDTSRGINSRLIRFLRHHQKDVFADKWPLLPTARLGNFEGWRGKTDWTAFYRQLWTDNLPAKYLQAFAIRTWDDHDVTLAHSHITVHVTDRGGTRRITTDGRTVAVGDTYLLPWEPRRATDPAKLYHHNPHGGTTTWTLPRGWAHRRTVHLHRLTTRGRTGTVALPVHRGRVTIEAAAGRPYVLTREPDPHGPAPADPDWGEGTPLRDPHFLSQTLDAWQITGPARVVESPLGDPELVVGAGAAATVSQRLARLQPGTYAASVQVEVGATAGERRRAALQVRTADGVTAVNWTDTSTAGNHMAADRKHGTRFQRMFTWFTVPDGGGPVTLALTVAAGRARVRFDALRVVPGRRTEAPPGTLVSEDFENVPQGWGPFVKGNAGGTTDPRTHIAQRHAPYTQRGWNRKAVDDVIDGTQSLKSRGENPGLVYRTVPHTVRFEPGHRYRVTFRYENEQAEQYAWVTAVDEPQPRELTRAPLPAATGPTTYSYDFTAPDTGEAWVGLRKVGESGTTEFCLDGFTVRQVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ0</accession>
    <name>A0A2G1XQJ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_00680</name>
        <name evidence="9" type="ORF">CYQ11_07690</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53480">
        <property type="protein sequence ID" value="PHQ53480"/>
        <property type="gene ID" value="BLA24_00680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12785">
        <property type="protein sequence ID" value="PPT12785"/>
        <property type="gene ID" value="CYQ11_07690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="9"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="530" mass="56447" checksum="75D85335979AB9DE" modified="2018-01-31" version="1">MDQLALLFVLLLGALVTVPLGDRLGVPSPVLMTIGGIVLALLPFVPNVAVPPEFILPLALPPLLYATAQRTSWRQFAANVRPILLLAVALVFVTTAAVAAVANAIMPGISLAAAVALGALVAPPDPVAATAVAGSLGLPRRLVSILEGEGLFNDVTAIVLYHVAIAAAVSGSFSLSRAVGELVLSAVVAVAVGLALGWAAKRLMDVLGDATLQIGLTLLVPFVAYVLAEELKGSGVLAVLTTALFLAEYAHDPDDVLGRLAGHTFWEVVDTLVTGAAFGLVGLELHNAVSTASGRWGEMLGVGGTVVAVVVGVRLLWLLPAAWVTKKLHKRRDVDEDVLLSWRETVVTWWSGMRGVATVALALAIPLTKDDKSPFPARDEILFVAFAVIIATLVVQGLTLPWLVKAVGVRKDIDASRELERQLATRAAKAARHRLLELVEDEDLSEDMMESLGRRAYDMGARISPDMVDEERRDAHAQRVERLRALHRLQGELLSAARHEVMAARSEPGMDPEVVDSVLRHLDERTLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X947</accession>
    <name>A0A2G1X947_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30185</name>
        <name evidence="5" type="ORF">CYQ11_23275</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47786">
        <property type="protein sequence ID" value="PHQ47786"/>
        <property type="gene ID" value="BLA24_30185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15411">
        <property type="protein sequence ID" value="PPT15411"/>
        <property type="gene ID" value="CYQ11_23275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="227" mass="24342" checksum="FBB6796D2F4A1D2F" modified="2018-01-31" version="1">MVQKAKILLVDDRPENLLALEAILSALDQTLVRASSGEEALKALLTDDFAVILLDVQMPGMDGFETAAHIKRRERTRDIPIIFLTAINHGPHHTFRGYAAGAVDYISKPFDPWVLRAKVSVFVDLYMKNCQLREQASLLRLQLESGQSGRGGAIEAQEPAGILAELSARLAAVEEQAEALSKQLDESADAAAVATAAHLERKLTGLRRALDALEPGTGGAGALPAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9I7</accession>
    <name>A0A2G1X9I7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30770</name>
        <name evidence="5" type="ORF">CYQ11_23865</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47892">
        <property type="protein sequence ID" value="PHQ47892"/>
        <property type="gene ID" value="BLA24_30770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15517">
        <property type="protein sequence ID" value="PPT15517"/>
        <property type="gene ID" value="CYQ11_23865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="21831" checksum="C65378C8F48663CF" modified="2018-01-31" version="1">MDSVLASDGDLYLPRTVRTAAKILVVGHFAVGKTTFVGSLSEIRPLRTEETMTQAGALVDDLAGIDGKTTTTVAMDFGRLTLSDSLVLYLFGAPGQQRFTRLWQDMTRGALGALVLADTRRLEQSFDVMGLLEEHGLPYAVAVNHFDGAPVHPEEEIREALDLLPETPLITCDARDRISSTRALITLVEYLSTRTAQEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9S8</accession>
    <name>A0A2G1X9S8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_31430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47973">
        <property type="protein sequence ID" value="PHQ47973"/>
        <property type="gene ID" value="BLA24_31430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013612363" description="SGNH_hydro domain-containing protein" evidence="2">
        <location>
            <begin position="39"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="65"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="539" mass="56819" checksum="23D6D31D63713588" modified="2018-01-31" version="1">MPLAPPRPCSATRLLVAALAAALTTSLAATAAVTPAAAAPAPDTAVTAPAGRQNWKVPRLAVMPLGDSITWGAGSSTRNGYRFALRDKLASHTDSLQFVGSVRTNGADHEGHSGWQIADLSENIERWLPAADPNVVLLHIGTNDMDLNNDVDGAPLRLGRLIDQITRAAPDMTLLVASLVPSQSAEMQKRVEKFNAEVPRLVAERRNKGFKVGYIDMSALTTRDLNDRLHPNDSGYTKMATAFYEGLTRAAGDGWLREHVDVKPPPPGHAPLGDYQVDINGDGKADYLVVEDNGSVHGYVNNGGDGHGGWIDQGIIATGTGAPGTKVRFADINADGKADYLVLDDNGSVHAWTNNSDTAKDSWTDRGVIATGTGALASRVRFADINADGKADYLVLDDNGSVHAWTNNGGDGHGGWTDQGIIATGTGVPANKVRFADINADRKADYLVLDDNGSVHAWTHNSDTAKDSWTDQGIIVSGTPTPDGGIRFSDIDGDGKADHLIVHDDGAVDALVNQGGGRGGWVDYGRIATGAGPGFRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA51</accession>
    <name>A0A2G1XA51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32125</name>
        <name evidence="3" type="ORF">CYQ11_25185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48091">
        <property type="protein sequence ID" value="PHQ48091"/>
        <property type="gene ID" value="BLA24_32125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15717">
        <property type="protein sequence ID" value="PPT15717"/>
        <property type="gene ID" value="CYQ11_25185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045999">
        <property type="entry name" value="DUF5955"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19380">
        <property type="entry name" value="DUF5955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="12533" checksum="ECAEBAFE1FE45CC2" modified="2018-01-31" version="1">MEGAVAVEEERVGRFGAEPDPRVDALSTAVSRLRRALAGHPVLLPDRDAAEDELAALDAMVRTGSPDVSRLRRSLLLVAGAVGSVSALAPALGEVRAAVDRFGGPSEGAGGEAELPRPREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA60</accession>
    <name>A0A2G1XA60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32280</name>
        <name evidence="5" type="ORF">CYQ11_25335</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48116">
        <property type="protein sequence ID" value="PHQ48116"/>
        <property type="gene ID" value="BLA24_32280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15741">
        <property type="protein sequence ID" value="PPT15741"/>
        <property type="gene ID" value="CYQ11_25335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="23490" checksum="5F6CB282EDAA92D7" modified="2018-01-31" version="1">MKGPATMSAPLFATASPLAVNVLDAQSLLAAFGVLGVGIVLFAETGLLVGFFLPGDSLLFTAGLLCTGSSAATGVHLSLAPLLLAAVAGTLAGSQCGYLIGRKAGGTLLARSRSARLHEGAQRAEALLERYGVGKAIVLARFVPVVRTVLNPMAGALGVPARSFTVWQVTGGLLWTVGLTLGGYALGSSIPNVDRYLLPIVALIVAVSLLPLAAELYRSRRAAAAQKNGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA99</accession>
    <name>A0A2G1XA99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonyl-CoA carboxylase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ccrA</name>
        <name evidence="2" type="ORF">BLA24_32545</name>
        <name evidence="3" type="ORF">CYQ11_25595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48156">
        <property type="protein sequence ID" value="PHQ48156"/>
        <property type="gene ID" value="BLA24_32545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15782">
        <property type="protein sequence ID" value="PPT15782"/>
        <property type="gene ID" value="CYQ11_25595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043880">
        <property type="term" value="F:crotonyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010085">
        <property type="entry name" value="Crot_CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01751">
        <property type="entry name" value="crot-CoA-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="49"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="445" mass="48990" checksum="46F02FD35804C156" modified="2018-01-31" version="1">MNQILDAILAPDSSAEDFAALAIPESYRAVTVHKDEAEMFAGLSTREKDPRKSLHVEDVPVPELGPGEALVAVMASSVNYNSVWTSIFEPVSTFSFLERYGRLSPLGKRHDLPYHVIGSDLAGVVLRTGPGVNAWKPGDEVVAHCLSVELESADGHDDTMLDPEQRIWGFETNFGGLAEIALVKSNQLMPKPAHLSWEEAAAPGLVNSTAYRQLVSRNGAAMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSEQKAEICRRMGAEAIIDRNAEGYKFWKDEHTQDPREWKRLGKRIRELTGGEDVDIVFEHPGRETFGASVYVTRKGGTIVTCASTSGYNHEYDNRYLWMSLKRIVGSHFANYREAWEANRLIAKGKIHPTLSKTYTLAETGQAAYDVHRNLHQGKVGVLCLAPEEGLGVRDEEMRARHIDAINRFRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAM3</accession>
    <name>A0A2G1XAM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33270</name>
        <name evidence="3" type="ORF">CYQ11_26320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48278">
        <property type="protein sequence ID" value="PHQ48278"/>
        <property type="gene ID" value="BLA24_33270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15908">
        <property type="protein sequence ID" value="PPT15908"/>
        <property type="gene ID" value="CYQ11_26320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="111" mass="11415" checksum="E1E4082607FAA0E6" modified="2018-01-31" version="1">MPFVTPPPAGNERPPGTAAGEPSTAAPFASAPAPTSAPRTAHSPAPPDAAAVARDVAQEVARRHAGLLADAVVPALGFSQRTRRAATRWQSQSPPAPPPTQDNPWGTYPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAS8</accession>
    <name>A0A2G1XAS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_33460</name>
        <name evidence="10" type="ORF">CYQ11_26510</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48311">
        <property type="protein sequence ID" value="PHQ48311"/>
        <property type="gene ID" value="BLA24_33460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15942">
        <property type="protein sequence ID" value="PPT15942"/>
        <property type="gene ID" value="CYQ11_26510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304865" evidence="6">
        <location>
            <begin position="40"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="35"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="178"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="473" mass="47616" checksum="E4BDBD444FF0E196" modified="2018-01-31" version="1">MGSSAHRRRPSRKAKLVGAGVAAAIATGAAFTLTGTAQAASVGAAFSTTGSWSGGYTGQYVVTNDTGEELSGWKLTFDLPAGTKITSLWNGKHSVSGQSVTVEPESWNGTIAPGKSVTVGFVASGGDAAATPANCRINGAKCSTDTHPGPRPTAPTVGPSQPQPEPTATSPAPGGATAGFAPYVDTSLYPAHDLLATAQKTGVKHFNLAFITSGGGCVPKWGGVTDLGADAVAAQIGRLRAAGGDVRVSFGGAAGSELGLACSSADDLAAAYGKVVDAYALTKVDFDIEGAALPDTAANTRRAQAIARLQKQHPGLDVSFTLPVMPTGLTQAGVDLVANAKKNGVSVSTVNIMAMDYGSSFSGDMGQYAIDAATATQAQIKGVLGLGDAAAWKAVAVTPMIGVNDVATEVFKVEDATQLAAFARSKGIGWLSMWSAARDKPCPGGPQNSASATCSSIQQDESAFSKAFAKPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB17</accession>
    <name>A0A2G1XB17_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ctaD</name>
        <name evidence="12" type="ORF">BLA24_29100</name>
        <name evidence="13" type="ORF">CYQ11_06375</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48434">
        <property type="protein sequence ID" value="PHQ48434"/>
        <property type="gene ID" value="BLA24_29100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12570">
        <property type="protein sequence ID" value="PPT12570"/>
        <property type="gene ID" value="CYQ11_06375"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="27"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="559" mass="61750" checksum="5DDE260769CA5BEF" modified="2018-01-31" version="1">MVSDTARAKEAAGPAGGRRRGRILVDWLTTTDHKKIGHLYLITSFVFFLLAGLLAMVMRAELARPGLQLVSNEQFNEVFTAHGTIMLLLFATPAFAGFANAIMPLQIGAPDVAFPRLNMFAYWLYLFGGLVVVSSLLMPEGGASFGWTAYAPLDSVVRSPGLGSDMWIMGLALSGFGTILGAVNFLTTVIGMRAPGMTMFRMPVFTWNVLFTSILVLLAFPVLAAALLCLEADRRFGAVVFEAPYGGALLWQHLFWFFGHPEVYIIALPFFGIITEIIPVFSRKPIFGYTMLIGATMSITALSVVVWAHHMFATGAVLLPFFSFMSFLIAVPTGVKFFNWIGTMWQGSLSFETPMLWSAGFLVSFLFGGLTGVILASPPLDFHVTDTYFVVAHFHYVVFGTVVFAMFAGFYFWWPKFTGKMLDERLGKVHFWTLFTGFHTTFLVQHWLGAQGMPRRYADYLAADGFTALNTVSSIGAFLLGLSTLPFLYNVGKTAKYGRRVDADDPWGFGRSLEWATSCPPPRHNFVTLPRIRSESPAFDLHHPETARRAEPSPAAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH7</accession>
    <name>A0A2G1XBH7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3068 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28210</name>
        <name evidence="4" type="ORF">CYQ11_07265</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48607">
        <property type="protein sequence ID" value="PHQ48607"/>
        <property type="gene ID" value="BLA24_28210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12712">
        <property type="protein sequence ID" value="PPT12712"/>
        <property type="gene ID" value="CYQ11_07265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="340" mass="38288" checksum="32A05ED345BF45C4" modified="2018-01-31" version="1">MRRRASLVLLALAVFFAALSPLLRWYAFPRLAKVPAGRYQTVVLEAKDATLIDYGTLEPRTVPRLTMIQTLKGNVEEANKVKKETGRDVVVWDTLSHAAGPDGAMVSQIPERYVFDAHSQQPVHAGGEHVDGTPVRRDGIEFKWPFLVEKRDYRYFDLMTRTSAPIHYRGTRDFHGLRVYYFEQTIPWTEVPLPRRLPLGITPDTVRALGLERWYSTRRMFWVDPTTGAPVNGEEVHQEEMRWTGHPEKKPITAFAGHVKMRPDYVDSTVALVKSQRQLVLLLTSYLPWGFLALGGALLVLSLVLEARDRRARAAELSHDGGKPERAAPGEGALSRGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBV5</accession>
    <name>A0A2G1XBV5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_28840</name>
        <name evidence="8" type="ORF">CYQ11_06625</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48713">
        <property type="protein sequence ID" value="PHQ48713"/>
        <property type="gene ID" value="BLA24_28840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12606">
        <property type="protein sequence ID" value="PPT12606"/>
        <property type="gene ID" value="CYQ11_06625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304827" evidence="5">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="82" mass="7887" checksum="D04C743A98C82264" modified="2018-01-31" version="1">MKNIKKAAAVTLAVGGLALAGAGAASAHGGHVGADATSKNNPGVVSGNVLQVPVEVPVNVCGNTVSVVGLFNTAHGNLCVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC52</accession>
    <name>A0A2G1XC52_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_27665</name>
        <name evidence="9" type="ORF">CYQ11_17975</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48844">
        <property type="protein sequence ID" value="PHQ48844"/>
        <property type="gene ID" value="BLA24_27665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14510">
        <property type="protein sequence ID" value="PPT14510"/>
        <property type="gene ID" value="CYQ11_17975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="38"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="456" mass="47901" checksum="B68ED4B41B323E82" modified="2018-01-31" version="1">MSSGHGADSAPAPNRHDDTRTTSLTVKGGMFRSLRVRNYRLFATGQVVSNTGTWMQRIAQDWLVLSLTGSSAAVGITTALQFLPMLLLGLYGGVIADRYPKRRLLLFTQAAMGVTGLALAVLTLSGHVQVWHVYLTALALGVVTVLDNPARQAFVVEMVGPADLRNAVSLNSANFQSARLVGPAVAGVLISALGSGWAFLLNGLSFLAPIAALLLMRNGELHKVDRAPRGKGQLREGLQHVAGRPELIWPIVLVGFIGTFGFNFPIWLTAFVNDVFHADASAYGLLNTVMAAGSLAGALLAARRGTSRLRLLIGAAAAFGLLEVMAALAPSFWVFAALLVPIGMCGLTINVTANSGIQLASDPALRGRVMSLFMMVFMGGAPLGAPLVGWVTDVYGPRVGFLAGGVVSLLAAAGIGLALARAGDLRLKVDLRRGHRHVAFVAREPSARQEAVTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG4</accession>
    <name>A0A2G1XCG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27930</name>
        <name evidence="3" type="ORF">CYQ11_17710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48891">
        <property type="protein sequence ID" value="PHQ48891"/>
        <property type="gene ID" value="BLA24_27930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14461">
        <property type="protein sequence ID" value="PPT14461"/>
        <property type="gene ID" value="CYQ11_17710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="34158" checksum="72CF4BD74D4FEFDB" modified="2018-01-31" version="1">MLEEVERWLARRSWSAADRPLDQLLAAKAGSGTTVSVVLPALDEEATVGEIAAVIRRELMTGDVPLVDELVVLDSGSTDRTAEVAAAAGARVEPRDAILPRLPALPGKGEVLWRSLLVTTGDVVCFVDADLKEFSADFVSGIVGPLLTDPDVDFVKAMYDRPLGSLSGQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAARRSLLERLPFPVGYGVELGLLVDALHTVGLDALAQVDVGVRKHRHQDGRALGRMAAAIYRTAQLRLARGHLVRPALTQFERTAEGFVPRTYEVDTLERPPMTEIPEYARRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCK2</accession>
    <name>A0A2G1XCK2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">BLA24_23040</name>
        <name evidence="7" type="ORF">CYQ11_23035</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48984">
        <property type="protein sequence ID" value="PHQ48984"/>
        <property type="gene ID" value="BLA24_23040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15371">
        <property type="protein sequence ID" value="PPT15371"/>
        <property type="gene ID" value="CYQ11_23035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="177" mass="19388" checksum="ADDD6FE98AABAF33" modified="2018-01-31" version="1">MSTTQSERLRELLAPLVSARELDLEEVEVTPAGKRRVLRIVVDSDEGVQLDTCADLSRDVSARLDETDVMGGAPYVLEVTSPGADRPLTQHRHYVRATGRLIKAQLVEGGELVARIVAVDDEGLDLEVPGVKGRKPTARRLAFAEIAKARVEIEFNRKSGRDAEEAVAETDESQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCR1</accession>
    <name>A0A2G1XCR1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PDZ domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_23080</name>
        <name evidence="13" type="ORF">CYQ11_22995</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48991">
        <property type="protein sequence ID" value="PHQ48991"/>
        <property type="gene ID" value="BLA24_23080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15364">
        <property type="protein sequence ID" value="PPT15364"/>
        <property type="gene ID" value="CYQ11_22995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="10">
        <location>
            <begin position="13"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="181"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="433" mass="46731" checksum="332B63A7E8F4FD56" modified="2018-01-31" version="1">MTTLMTVLGIVVFVVGLLFSIAWHELGHLSTAKMFGIRVPQYMVGFGPTVFSRKKGDTEYGLKAVPLGGYIRMIGMFPPGEDGKISARSTSPWRGMIEDARSAAYEELRPGDETRMFYTRKPWKRVIVMFAGPFMNLVLAVVIFLGVMMSFGVNTQTTTVSAVSDCVVAASSQTDKCAKGDKDSPAKAAGLRPKDKIVAFDGRRIGDWSTLQKDIRKTTGPATITVLRDGERLTLHADLISNQVQKYDGKGAPIKGQYVTAGFLGFTPATGVVQQSFGQSVDRMGDMVQSGVESLVALPGKIPDLWNAAFDGGERKADSPMGVVGAARVGGEVFNLDIPPSQQIATMLFLVAGFNLSLFLFNMLPLLPLDGGHIAGALWESVRRAVAKVFRRPDPGPFDVAKLMPVAYVVAGIFVCFTLLVLIADVVNPVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCW7</accession>
    <name>A0A2G1XCW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">HU family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_23510</name>
        <name evidence="6" type="ORF">CYQ11_22560</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49060">
        <property type="protein sequence ID" value="PHQ49060"/>
        <property type="gene ID" value="BLA24_23510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15294">
        <property type="protein sequence ID" value="PPT15294"/>
        <property type="gene ID" value="CYQ11_22560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="235" mass="24016" checksum="31E874AAD04F59C9" modified="2018-01-31" version="1">MNKAQLVEAIADKLGGRQQAADAVDAVLDAMVRAVVAGDRVSVTGFGSFEKVDRPARYARNPQTGERVRVKKTSVPRFRAGQGFKDLVAGTKKLPKGDEVAVKKAPKGSLSGGKVTAKAAAKKATAKKAAAKKATTAKKATTAKKAAPTKAAAKKTTTAAAKKTTAKKTTAKKATPATKAAAAKKTTAKKAAPAAAKKATAKKTAPAKKATATKAPARKTTARKTTAKKTAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCY8</accession>
    <name>A0A2G1XCY8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23645</name>
        <name evidence="4" type="ORF">CYQ11_22425</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49082">
        <property type="protein sequence ID" value="PHQ49082"/>
        <property type="gene ID" value="BLA24_23645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15272">
        <property type="protein sequence ID" value="PPT15272"/>
        <property type="gene ID" value="CYQ11_22425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="211" mass="22969" checksum="5AF59C394CF6DE73" modified="2018-01-31" version="1">MTDETGLRERKKQRTRQALSDTAIELFLKRGFDKVSVADVAAAVEVSKPTLFRYFPAKEDLALHRIADHQGEAARVVRDRTPAHSPLAALRAHFHERLDAHDPVTGLNGNATVRAFNDMLYTTPSLLARLVRYADRDEELLAGALLETGGGDGLTAGLAAAQIITVHQRLAQENWRKLASGRTVTEALPEAHADADLAYDLLGAGLGPRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDG7</accession>
    <name>A0A2G1XDG7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">B/F/G family RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_24810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49283">
        <property type="protein sequence ID" value="PHQ49283"/>
        <property type="gene ID" value="BLA24_24810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="173"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="312" mass="35003" checksum="9EB284B08C873524" modified="2018-01-31" version="1">MSTASSRGVRTPAIPQQPARPHPAEPAPDQASPEVDRASDPPERADHMDQHRHRQRHAHSDPHDRSGARALFVELRALPDGSAERAELRNNLVRMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVDRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLALTTATAELSQRHGRAPTVHELAEHLGISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGAEDEALEGVEYRESLKPLLEDLPPREKKILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTLAQLRERLLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE06</accession>
    <name>A0A2G1XE06_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25530</name>
        <name evidence="2" type="ORF">CYQ11_20545</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49409">
        <property type="protein sequence ID" value="PHQ49409"/>
        <property type="gene ID" value="BLA24_25530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14941">
        <property type="protein sequence ID" value="PPT14941"/>
        <property type="gene ID" value="CYQ11_20545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6000" checksum="28A0143CB1CDE62F" modified="2018-01-31" version="1">MNATGDVVELVEKPGGALDDVLVVALGGDGAPPLPGPGAVPPRASADELLRARCEALRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XED2</accession>
    <name>A0A2G1XED2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26585</name>
        <name evidence="3" type="ORF">CYQ11_19050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_071965776.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49593">
        <property type="protein sequence ID" value="PHQ49593"/>
        <property type="gene ID" value="BLA24_26585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14688">
        <property type="protein sequence ID" value="PPT14688"/>
        <property type="gene ID" value="CYQ11_19050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="16206" checksum="A868A4CE728609DF" modified="2018-01-31" version="1">MSLYAAYAGNLDARLMTRRAPHSPLRGTGWLNGWRLTFGGEQMGWEGALATIVEAPRSQVFVALYDIAPMDEDSMDRWEGVGLDIYRRMRVRVHTLDGEEPAWVYVLNGYEGGLPSARYLGEIADAAESAGAPHDYVMELRKRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI1</accession>
    <name>A0A2G1XEI1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26845</name>
        <name evidence="3" type="ORF">CYQ11_18790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49636">
        <property type="protein sequence ID" value="PHQ49636"/>
        <property type="gene ID" value="BLA24_26845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14643">
        <property type="protein sequence ID" value="PPT14643"/>
        <property type="gene ID" value="CYQ11_18790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20526" checksum="709EC7F21C6FBACA" modified="2018-01-31" version="1">MSGQDELDASSEALGQITKGIDDAIGELKELGMGMTGAANTGRGFDDLALSGLETGHDGLTSAFKTFCERWEWGVRSLVHDGNEFARRVGLSAGMYHEQDKYVKGTFKVVVAGFGADPTLADKDVQEMSVDEIADHGNFAHADYSGKSFEDAFHHVVETDKATAKDAVESGKVGPATLLADQAERARRAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XET4</accession>
    <name>A0A2G1XET4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25385</name>
        <name evidence="4" type="ORF">CYQ11_20690</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49732">
        <property type="protein sequence ID" value="PHQ49732"/>
        <property type="gene ID" value="BLA24_25385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16694">
        <property type="protein sequence ID" value="PPT16694"/>
        <property type="gene ID" value="CYQ11_20690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304664" evidence="2">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="112" mass="11934" checksum="052A6E7A44C78E03" modified="2018-01-31" version="1">MFWFLLIALVVVVAAVTLAVAGGGGAEVLPEAVPDRLAWPLPGARPLGRADVEALRLPMALRGYRMAETDDVLDRLGAELAERDARIAELEAALAGAQAAAMRREKEEGEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF84</accession>
    <name>A0A2G1XF84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19690</name>
        <name evidence="3" type="ORF">CYQ11_11105</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49865">
        <property type="protein sequence ID" value="PHQ49865"/>
        <property type="gene ID" value="BLA24_19690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13359">
        <property type="protein sequence ID" value="PPT13359"/>
        <property type="gene ID" value="CYQ11_11105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="27040" checksum="D992B4443A2E0CF9" modified="2018-01-31" version="1">MKLTVVGCSGSFPSTESACSSYLVEAEGFRILLDMGNGALGELQRHIGLYDLDAVLLSHLHPDHCIDMCGYFVARYYRHDGGRAHAIPVYGPEGTERRLVTAYGDVPDEACMSEVFDFRTLTPGGFALGPFTIRADRVRHPVEAYAFRVEHEGSSLVYSGDTGPCEALRKLSEGADLLLCEASFTHGKEDIPDLHLTGLQAGETAAAGGVGRLVLTHIPPWTDPLTNLRDARSVYEGPAELAHAGAVYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD1</accession>
    <name>A0A2G1XFD1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_19550</name>
        <name evidence="9" type="ORF">CYQ11_11245</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49839">
        <property type="protein sequence ID" value="PHQ49839"/>
        <property type="gene ID" value="BLA24_19550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13385">
        <property type="protein sequence ID" value="PPT13385"/>
        <property type="gene ID" value="CYQ11_11245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="58"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="25522" checksum="01AA08A950102714" modified="2018-01-31" version="1">MSEMSSPEQMIAEARKACFVMCGFLAALWAVQLVNWGCDYSLVREHALVSGDVETLPALVTAPLLHLNWAHIESNSGPLFIFGFLAAYRGVARFFGLTALVALTSGLAIWFFERADVGTVGASGLVFGYFGYVVVRGFFDRHLVDSLVGVVMAASFAYTFTGVVPGTPGISWLGHLGGFVGGVAGAWVFRDRVEKAKPRGGKGPEESQGPSGSKGLAVPAARGESPRADLHKELRDLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFJ7</accession>
    <name>A0A2G1XFJ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-ACP desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20615</name>
        <name evidence="9" type="ORF">CYQ11_10165</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50016">
        <property type="protein sequence ID" value="PHQ50016"/>
        <property type="gene ID" value="BLA24_20615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13206">
        <property type="protein sequence ID" value="PPT13206"/>
        <property type="gene ID" value="CYQ11_10165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="324" mass="36613" checksum="07693D281532B2DF" modified="2018-01-31" version="1">MTTAPTLSHGRAWSDTKLLYALEEVVATELDRHLKVAKEWMPHEYVPWSEGRDFDGVMGGEAWAPEQSKVSAIGRTALVVNLLTEDNLPSYHHEIASLFGRDGAWGTWVHRWTAEEGRHGIVMRDYLLTSRAVDPVALERFRMQHMSEGFESDNRHSMLHSVAYVAFQELATRISHRNTGHHSGDPVCDRMLSRIATDENLHMVFYRNLLGKAFELAPDQTMSAVRDVVVDFRMPGHGIPGFERAAAQMAIGGIYNLRIHHDDVLQPVLRFLKVLQIGGLGPEGLRAQEELGLFMGGLDDQARKFDEKREALLARRRARAERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ8</accession>
    <name>A0A2G1XFQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional folylpolyglutamate synthase/dihydrofolate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_20860</name>
        <name evidence="8" type="ORF">CYQ11_09920</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50057">
        <property type="protein sequence ID" value="PHQ50057"/>
        <property type="gene ID" value="BLA24_20860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13164">
        <property type="protein sequence ID" value="PPT13164"/>
        <property type="gene ID" value="CYQ11_09920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="118"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="374"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="515" mass="54600" checksum="FC9F78D57E6FAC12" modified="2018-01-31" version="1">MTERPLNDDTGDHESGEPGENGVPDEFEEIVGAETDRDPDLAVIEAGSRTLRTQAGPPQGDGVPARPEDPEVDRALREVEAELAGRWGETKLDPSLVRMEALMDILGQPQRSYPSIHITGTNGKTSTARMIEALLAAFDLRTGRYTSPHVQSVTERISLDGAPISAERFIETYRDVQPYVQMVDDREEYRLSFFEVLTGMAFAAFADAPVDVAVVEVGMGGTWDATNVVDGTVAVVTPIALDHTDRLGETPGEIAGEKAGIIKADATVVLAQQPVDAAQALLKHSVGVDATVAREGMEFGVTAREVAVGGQLLTLRGLGGDYEDVFLPLYGAHQAHNAAVALAAVEAFFGIGSQHARTLDIDTVRRAFASVTSPGRLEVVRRSPTVVLDAAHNPAGARVTAEGVTEAFGFSRLVGVVGTSADKDVRGLLEAFEPIFAEIVVTRNSTPRAMDVDELAGLAVEVFGAERVQVEPRLDDALEAAITLAEEEGEYSGAGVLVTGSVVTVGEARLLLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS9</accession>
    <name>A0A2G1XFS9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_21100</name>
        <name evidence="13" type="ORF">CYQ11_09685</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50094">
        <property type="protein sequence ID" value="PHQ50094"/>
        <property type="gene ID" value="BLA24_21100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13126">
        <property type="protein sequence ID" value="PPT13126"/>
        <property type="gene ID" value="CYQ11_09685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="410" mass="44202" checksum="7A6014F35E95D172" modified="2018-01-31" version="1">MPSVLPDGEPMPEDGALPRRALDGSGQRPLGFYLHVPYCATRCGYCDFNTYTASELRGSGGALASRDNYADTVAEEIRLARKVLGDDPRPVETVFVGGGTPTLLPAADLGRMLAAIRDEFGLADGAEVTTEANPESVDPRYLEELRAAGFNRVSFGMQSARQHVLKVLDRTHTPGRPEACVAEARAAGFEHVNLDLIYGTPGESDDDWRASLDAVVGAGPDHVSAYALIVEEGTQLARRIRRGEVPMTDDDVHADRYLIAEETLSGAGFSWYEVSNWATTEAGRCRHNELYWRGADWWGAGPGAHSHVGGVRWWNVKHPGAYAQALSEGRSPGAGREVLADEDRRVERILLELRLVDGCPLSLLKPAGAAAAARALADGLLQPGPYEAGRAVLTLRGRLLADAVVRDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFV2</accession>
    <name>A0A2G1XFV2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">BLA24_21265</name>
        <name evidence="9" type="ORF">CYQ11_09520</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50118">
        <property type="protein sequence ID" value="PHQ50118"/>
        <property type="gene ID" value="BLA24_21265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13101">
        <property type="protein sequence ID" value="PPT13101"/>
        <property type="gene ID" value="CYQ11_09520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18155" checksum="67BA0F554E028305" modified="2018-01-31" version="1">MAIDVNNESGTEVDEQAILDVARYALARMRIHPLSELSVIVVDAEAMEQLHIQWMDLPGPTDVMSFPMDELRPPAKDDDEPPQGLLGDIVLCPEVARKQGEEAPTGHSMDEELQLLTVHGVLHLLGYDHEEPDEKAEMFGLQAAIVDGWRAEHGIEGPSPAPTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFX2</accession>
    <name>A0A2G1XFX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21385</name>
        <name evidence="2" type="ORF">CYQ11_09400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50140">
        <property type="protein sequence ID" value="PHQ50140"/>
        <property type="gene ID" value="BLA24_21385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13079">
        <property type="protein sequence ID" value="PPT13079"/>
        <property type="gene ID" value="CYQ11_09400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="423" mass="43945" checksum="97CB2B6F2ADB43C2" modified="2018-01-31" version="1">MIDDDVAGLNAVATDYTSAVGKYDSTSRALNRKVNAVVHEAGWSGEGAEAFQTVWANDGTVAAAISEAMSQVSDIVSVLAEELAAARGDLGDAQDTARAAGLTLDSQGGAEGKADRQAALDAYRKGRDAALGRAQNARELATRSLNSVLDQILNKGDAKVYNGADACTLAEVLRGLYTTPAALSQESAKKLARLRQGAKDLKRGHNKLPRGSDAWNERLQQRRAARAALSEQRLRTASVEGWRSRVKGSGAARVTIGDIAEDYRVRGVGAVGKLGAASAGLTGAMVGLQMYDDRRTRGWSYGEAFTRDAAPAAAGMAIGTAVEGGIVGASAANPVVALGVVSGVVVGYGVGTLGYELTHNAHWGSNIHKYGVVDGIGHSLAQAGGEWVKNDLEGMKDRGVETAKKVGSGIKSGAENVWHGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFX6</accession>
    <name>A0A2G1XFX6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21320</name>
        <name evidence="3" type="ORF">CYQ11_09465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50127">
        <property type="protein sequence ID" value="PHQ50127"/>
        <property type="gene ID" value="BLA24_21320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13092">
        <property type="protein sequence ID" value="PPT13092"/>
        <property type="gene ID" value="CYQ11_09465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="116" mass="12374" checksum="F7B293DF9545BBD6" modified="2018-01-31" version="1">MTAPRTDWRPLVKAVAYVAGAVVPLVASTWLWPSDPAALLWLVGLALLWRAPYWRTRQKGIATLATGVFPVGAVLWLYGLLPRDLGQGGSVLAALLLLAIPSGTGLYLLGTVRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFY7</accession>
    <name>A0A2G1XFY7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21370</name>
        <name evidence="6" type="ORF">CYQ11_09415</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50137">
        <property type="protein sequence ID" value="PHQ50137"/>
        <property type="gene ID" value="BLA24_21370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13082">
        <property type="protein sequence ID" value="PPT13082"/>
        <property type="gene ID" value="CYQ11_09415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="215" mass="23075" checksum="21657B5536FC452E" modified="2018-01-31" version="1">MRAVIAEDSVLLRVGLVKVLEAAGFEVVAETGDAEAVLAAARLHEPDLAVLDVRMPPSFTDEGVRAALALRASHPATAVLLLSQYVEERYATDLLTGETAGFGYLLKQRVADVEEFIDAVRRVAAGGTALDPQVVSQLLTRRHSDPLDRLTPREREVLASMAEGRSNAGIAEQLVVSESAVAKHINNILAKLDLPKAEADHRRVLAVLRFLGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG37</accession>
    <name>A0A2G1XG37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21590</name>
        <name evidence="6" type="ORF">CYQ11_09195</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50171">
        <property type="protein sequence ID" value="PHQ50171"/>
        <property type="gene ID" value="BLA24_21590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13046">
        <property type="protein sequence ID" value="PPT13046"/>
        <property type="gene ID" value="CYQ11_09195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PTHR21325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="4">
        <location>
            <begin position="62"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="296" mass="31956" checksum="A545DBE7AC61D667" modified="2018-01-31" version="1">MGASRRRGPYGGVRAAVRAAGAALALALLATGCDDGGTEGKSAAPSPPRSAWNTHPRSIASLGDSITRGFDACSVLEDCPEASWATGTRVDSLARRLLASPQTSSWNYAKTGARMADLPGQMRSAIAQKPQLVTVLLGANDACRANVAAMTPVADFRTDFEGAMRQLRLELPKTQVYVAGVPDLMRLWSEGHKNMIGRQVWKLGSICPSMLHDSESTDEASAARRVQVDQRVREYNAVLKDVCSRDELCRFDDTVHGYGFTGQELSKWDWFHPSQKGQGQLAAMAYRTITAENPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG39</accession>
    <name>A0A2G1XG39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21820</name>
        <name evidence="2" type="ORF">CYQ11_08965</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50210">
        <property type="protein sequence ID" value="PHQ50210"/>
        <property type="gene ID" value="BLA24_21820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13006">
        <property type="protein sequence ID" value="PPT13006"/>
        <property type="gene ID" value="CYQ11_08965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="218" mass="23541" checksum="B8DD8D54FFDC9547" modified="2018-01-31" version="1">MIHMTETLAVHTLEGFLTPEETAQVTKLLDEHLEATRWVPARPSEGTVPPEAVQEILAAGIARALPAIRRVFPSVAAATPWDYHDLGPGDRIDAHLHGVGEPDARPQRVARVAFHLQEASRGGEFYVDTCSAEDLWTSRVAGSGSAFVPGTRFAREVSHEGRPEDLAALAGIPRTRWTSAPPAGTAVVYGAQLVHGVETVREGRLRKLITNLLDGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGH2</accession>
    <name>A0A2G1XGH2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22000</name>
        <name evidence="3" type="ORF">CYQ11_08785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50239">
        <property type="protein sequence ID" value="PHQ50239"/>
        <property type="gene ID" value="BLA24_22000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12976">
        <property type="protein sequence ID" value="PPT12976"/>
        <property type="gene ID" value="CYQ11_08785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="248" mass="27351" checksum="08857167810D0AE2" modified="2018-01-31" version="1">MLTVDFSRFPLAPGDRVLDLGCGAGRHAFECYRRGARVVALDRNGEEIREVARWFAAMKEAGEAPEGATATAMEGDALALPFPDDSFDVVIISEVMEHIPDDKGVLAEMVRVLRPGGRIAVTVPRYGPEKVCWALSDAYHEVEGGHIRIYKADELLEKMREAGLKPYGTHHAHGLHSPYWWLKCAFGVDNDKALPVRAYHKLLVWDIMKKPAATRVAEQLLNPVIGKSFVAYATKPHLPADAVAGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGP3</accession>
    <name>A0A2G1XGP3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21195</name>
        <name evidence="3" type="ORF">CYQ11_09590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50403">
        <property type="protein sequence ID" value="PHQ50403"/>
        <property type="gene ID" value="BLA24_21195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16451">
        <property type="protein sequence ID" value="PPT16451"/>
        <property type="gene ID" value="CYQ11_09590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="16847" checksum="B14BA707480DE62E" modified="2018-01-31" version="1">MARRHASCWAGSVIKIRTAVQADAENVLTFWKEAAEGTSITDDTDGVTRLIERDPEALILAESEGLLVGSVIAGYDGWRCSLYRLAVRPSHRRQGIATALLTAAEERFRAVGGRRGDAMVLEANERAQHAWAAAGYEREDHWRRWVKPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGV4</accession>
    <name>A0A2G1XGV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16480</name>
        <name evidence="4" type="ORF">CYQ11_16805</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50445">
        <property type="protein sequence ID" value="PHQ50445"/>
        <property type="gene ID" value="BLA24_16480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14303">
        <property type="protein sequence ID" value="PPT14303"/>
        <property type="gene ID" value="CYQ11_16805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="152"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="306" mass="31047" checksum="EB4E320D8407537D" modified="2018-01-31" version="1">MNAHLSSEPVSPQDRPARLTVGVVGAGRVGPALAASLQLAGHRPVAVSGVSDASRRRAAALLPGVPVTTPAEVLARAELVLLTVPDDALPDLVAGLARTGAVRPGQLLVHTSGRHGTAVLDPATRAGGLPLALHPAMTFTGTPVDVQRLAGCSFGVTAPQELRLAAEALVIEMGGEPEWIEEAARPLYHAALALGANHLVTLVAQAMEVLRTAGVENPARMLGPLLGAALDNALRSGDAALTGPVARGDAGTVAAHITELRSHAPQAVAGYLAMARTTADRALAHGLLKPELAEDLLGVLADGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHA7</accession>
    <name>A0A2G1XHA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17600</name>
        <name evidence="3" type="ORF">CYQ11_15675</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50613">
        <property type="protein sequence ID" value="PHQ50613"/>
        <property type="gene ID" value="BLA24_17600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14132">
        <property type="protein sequence ID" value="PPT14132"/>
        <property type="gene ID" value="CYQ11_15675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="607" mass="65971" checksum="A3F8086C6D45E009" modified="2018-01-31" version="1">MSADDTEGPRDAGIEGVRERTVRTGGIELCVAELGDPADPTVVLLHGYPDSKEIWAEVAHRLRDRFHVVLYDVRGHGRSTAPRPLRGGFTLEKLTDDFLAVLDAVSPEAPVHLVGHDWGSVQGWEFVTVARTEGRVASFTSVSGPSLDHFGLWIKRRLSRPTPRRVAQLLGQGARSWYVYALHTPALPEAAWRGALGRRWPRLVERSEGLPRTVPGRPGTYPTASLPSDAAHGAWLYRDNVRARMRRPRTDAYAHVPVQLITPVGDAFLSARLYDDLEQWAPRLVRRTLSAKHWVPRTRPDQLAAWITEFVTAQETARQEGAPDRPAVGKGRHAPWFGGRLVLVTGAASGIGRATAFAFAEAGARVVAVDRDAEGAARTAELARLTGAPEAWAECCDVSDESAMEKLATHVADTYGVVDVLVNNAGIGVAGTFMDTTPKDWRDVLGVNLWGVIHGCRVFGRQMAERGQGGHIVNTGSAAAFQPFKTLTAYSTSKAAVLMLSECLRAELAGQGIGVTAICPGVVNTGITATTRFAGVSAQEQDRRRAKAVRLYGKRNYPPEKVAEAILDAVVRDRAVVPVTPEAHVMRFLSRLTPRVSRALARLDPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHJ7</accession>
    <name>A0A2G1XHJ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrmH family RNA methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18205</name>
        <name evidence="3" type="ORF">CYQ11_15070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50718">
        <property type="protein sequence ID" value="PHQ50718"/>
        <property type="gene ID" value="BLA24_18205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14028">
        <property type="protein sequence ID" value="PPT14028"/>
        <property type="gene ID" value="CYQ11_15070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="26916" checksum="C924D31E4319BEA9" modified="2018-01-31" version="1">MTEDDAQAAAALRQWRERAPDAVLLDGFHALKHALRFGADVRPALAGDKAAALALAAGLAPDLSEGLDRLLVEVPARELRELVPRIHATGVAALAARRDRRANLDALSRRPRQAPVVVLDNPRNLGNVGAVVRLAAGFGATGVVTTGDVDPWHPNAVRSGAGLHYATAVERLDLGELPDGPLYALDPEGEDIRSLTLPDDALIAFGSERHGISAELRGRADRLVSLPMRPQVSSYNLATSVAMALFHWGGPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHS7</accession>
    <name>A0A2G1XHS7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YIP1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_18615</name>
        <name evidence="9" type="ORF">CYQ11_14665</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50785">
        <property type="protein sequence ID" value="PHQ50785"/>
        <property type="gene ID" value="BLA24_18615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13957">
        <property type="protein sequence ID" value="PPT13957"/>
        <property type="gene ID" value="CYQ11_14665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="181"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="36012" checksum="0597F7A21CD284EE" modified="2018-01-31" version="1">MSQLGRKAGPPTAARLRYPPGAGTFEGVAGFRMGRGRDPQGAGPARQGQQQAPYGGSGAPGHPGAPAGGYGGGPQQWGHQPGGYDEPEYLGGGAPQQPGYGQQGQHGRPGPYGQPAQYGQPYGGGAPAGGPAPYPGDPGQTQQFSLGEAPDAYDPYGDGGGHTAPAPPPGPRLHWKELLSGIVLRPNDTFWRMRDHQMWAPALIVTFVYGLLAVFGFDKARKDVLGASLADVLPAVLVTGVIMVVAGLILGAVTHTLARQLGGDGIWQPTVGLSMLIMSISDAPRLLFAMFLGGDSTLVQVLGWATWLAGGVLLTSMVSKSHDLPWPRALGASAIQLVALLSLIKLGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHT8</accession>
    <name>A0A2G1XHT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_00135</name>
        <name evidence="11" type="ORF">BLA24_18670</name>
        <name evidence="13" type="ORF">CYQ11_14610</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000006">
        <property type="protein sequence ID" value="PHQ53590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50795">
        <property type="protein sequence ID" value="PHQ50795"/>
        <property type="gene ID" value="BLA24_18670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53590">
        <property type="protein sequence ID" value="PHQ53590"/>
        <property type="gene ID" value="BLA24_00135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13947">
        <property type="protein sequence ID" value="PPT13947"/>
        <property type="gene ID" value="CYQ11_14610"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ53590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="40840" checksum="5DA625D361A6D678" modified="2018-01-31" version="1">MDRVREALRRALPALGMYAAARLTGMTVMAAWAWWIGKHPRTLLGHLWDGIWYTGIARNGYGLVLPSPTTKGVIFNDLAFFPLYPGLVRAVATVLPLTVVSAGLLVAWASAALAAWGVYAVGERLYGRRAGTFLVLLWGLLPHAIVQTMAYTESLMTALAAWALYALLTGRWLWAGGLALLAGLSRPNAIAVAAAVWCAVALALWRDARTRRDWRPWAAAGLAPLGWAGYVLWAGVRSGDGPLGYFAVQRRWGSRFDFGRDAFRFVRHLIVARDYLAYYATVAVLAVALLALLHLALHRPPAPLLVYVLVLVVIAVGGSSYFASKPRFLLPAFPLLVPAAMAMAKARPRTLAVTAGALAGLSFFYGTYLLAVARVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHU8</accession>
    <name>A0A2G1XHU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3151 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18725</name>
        <name evidence="3" type="ORF">CYQ11_14555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50803">
        <property type="protein sequence ID" value="PHQ50803"/>
        <property type="gene ID" value="BLA24_18725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13939">
        <property type="protein sequence ID" value="PPT13939"/>
        <property type="gene ID" value="CYQ11_14555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014487">
        <property type="entry name" value="DUF3151"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11349">
        <property type="entry name" value="DUF3151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017349">
        <property type="entry name" value="UCP017349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14783" checksum="DCCBEF8B42332D69" modified="2018-01-31" version="1">MSIHENLLGGPPPTHLPDDPEPRELLASGAAPAEVAAKYPASSLAWAQLADEAFEGGRVVESYAYARTGYHRGLDALRRSGWKGHGPVPFEHEPNRGFLRALHALARAAQAIGEHEEYERCSTFLRDSSPTAANTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI03</accession>
    <name>A0A2G1XI03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_18815</name>
        <name evidence="7" type="ORF">CYQ11_14465</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50821">
        <property type="protein sequence ID" value="PHQ50821"/>
        <property type="gene ID" value="BLA24_18815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13921">
        <property type="protein sequence ID" value="PPT13921"/>
        <property type="gene ID" value="CYQ11_14465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="231" mass="24386" checksum="DDC58F5324495332" modified="2018-01-31" version="1">MGETSVLVVDDDPDVRAAVVDGLAVEGYAVRAAADGLEALSAVAAAPPAAIVLDLAMPVLDGLAVCRRLREIGDRTPVLVLTARDAVSDRVAGLDAGADDYLVKPFALDELLARLRALLRRAAPAGPAGAAAGELAFADLTVDPETRTGERAGTPLEFTRTEFALLEVFLRHPGQVLAREVIQERVWGADFGPESNSLAVYIGYLRRKLEAGGASRIVHTVHGVGYRLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI21</accession>
    <name>A0A2G1XI21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I restriction endonuclease subunit S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_17100</name>
        <name evidence="6" type="ORF">CYQ11_16175</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50873">
        <property type="protein sequence ID" value="PHQ50873"/>
        <property type="gene ID" value="BLA24_17100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16599">
        <property type="protein sequence ID" value="PPT16599"/>
        <property type="gene ID" value="CYQ11_16175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="338" mass="37393" checksum="9E7B028B362A648A" modified="2018-01-31" version="1">MNVLHVDQVVMRKLTAWEGPITVVPAEFDGFVVSNEFPTFTLGPELMPDWMRHVCRSPRLWAEMKNRVSGTVQRRKRLNPEQLLQIQLPIPPREVQARIIEMLDAVDDQITALDAEADALSKVESGLRRNLFNRLVVPVVPAGEKFEMRLGRQKSARQSIGDHVHPYLRAANIGVGTLDLSDLKTMNFEPREQEKYAVHPGDVLLVEGGSIGQAALWAGEVDGFVGFDKHVIRIRAREGVSTPEYALQWCHWAREDGQFAGQATGITIKALGFSRASNMSVPDLPVAQQARLTGPLAAAAEQVVATRAEASRLRQVRAALLSGLLDRTIDIESADSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI27</accession>
    <name>A0A2G1XI27_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18450</name>
        <name evidence="3" type="ORF">CYQ11_14830</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50904">
        <property type="protein sequence ID" value="PHQ50904"/>
        <property type="gene ID" value="BLA24_18450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16571">
        <property type="protein sequence ID" value="PPT16571"/>
        <property type="gene ID" value="CYQ11_14830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="262" mass="28146" checksum="4607731CE4567968" modified="2018-01-31" version="1">MQGGRMTASEPASATTWKVGPLAAASGLTVRTLHHWDTIGLLSPSRRTAGGHREYDGDDVARLYQVLALRSLGLGLETITVCLDRGIDPVRLVHDHLGRVEASIAALDDVRRRLVRLGEELAGDETPSTTSLLDALRALGRTGPESEGALGRHLDADQVEVLRTRGAALGPAAHYLLEVEWPELYRRAEALRTAGVAPTDARVRRLVARMDELSTLFTGGDAGIAAGVRRAWHEDPAAMSGDAAAPADEWREVAAYLGEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIA1</accession>
    <name>A0A2G1XIA1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14250</name>
        <name evidence="3" type="ORF">CYQ11_13825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50953">
        <property type="protein sequence ID" value="PHQ50953"/>
        <property type="gene ID" value="BLA24_14250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13826">
        <property type="protein sequence ID" value="PPT13826"/>
        <property type="gene ID" value="CYQ11_13825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="428" mass="46739" checksum="FB3326E537473D52" modified="2018-01-31" version="1">MTESPTEHSADVIVVGAGPAGSTTAYYLAKAGLDVLLLEKTAFPREKVCGDGLTPRATKQLVAMGIDISEEAGWLRNKGLRIIGGGVRLQLDWPDLASFPDYGLVRKRDDFDEQLARQAEKAGARLYERCNVGAPVIDDRTGHITGVHAKLGEEKTPVTFHAPLVVAADGNSSRLSLAMGLHRREDRPMGVAVRTYFTSPRHDDDYLESWLELWDRRGPGPDRLLPGYGWIFGMGDGTSNVGLGVLNTSDSFKELDWREVLKAWCASMPEDWGYTPENMTGPIRGAALPMAFNRQPHYTRGLLLVGDAGGLVNPFNGEGIAYAMESGQLVADVIVQAHARASYAQRELALQRYPKVLKETYGGYYTLGRAFVKLIGNPKVMQIATQRGLSHPLLMKFTLKMLANLTDPTGGDAMDRIINGLSKVAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIF0</accession>
    <name>A0A2G1XIF0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_14530</name>
        <name evidence="2" type="ORF">CYQ11_13545</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51003">
        <property type="protein sequence ID" value="PHQ51003"/>
        <property type="gene ID" value="BLA24_14530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13775">
        <property type="protein sequence ID" value="PPT13775"/>
        <property type="gene ID" value="CYQ11_13545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="100" mass="10827" checksum="3926972061491662" modified="2018-01-31" version="1">MDEDEDLRLRAIAPEISRVTIGLMRKTVGLEPAERVPEEALCVADDVLAKHGTDGLRVLIMSLAGWMTVGIENIAHLTGKTNEAVVDDIELTCMEANPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIV9</accession>
    <name>A0A2G1XIV9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_15605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51182">
        <property type="protein sequence ID" value="PHQ51182"/>
        <property type="gene ID" value="BLA24_15605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="46"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="202" mass="19816" checksum="24298C6459BE6C3A" modified="2018-01-31" version="1">MGPPRGRRRGGGVSAGPHGHPAAGVPFPGDPEGLGGALLADAHSALVVTASNRAAAGVYPDKGGPLLAEGLAAMGFAVDGPLVVPDGEPVEQALRAGAAAGYDVVVTTGGTGVSPTDRTPEATRAVLDYEIPGIPEALRAEGLAKVPTAALSRGLAGVAGRTLIVNLPGSTGGVRDGLAVLGRLLVHAVEQIHGGDHPRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIX0</accession>
    <name>A0A2G1XIX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclohexanone monooxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15700</name>
        <name evidence="2" type="ORF">CYQ11_12375</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51198">
        <property type="protein sequence ID" value="PHQ51198"/>
        <property type="gene ID" value="BLA24_15700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13578">
        <property type="protein sequence ID" value="PPT13578"/>
        <property type="gene ID" value="CYQ11_12375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="513" mass="56266" checksum="30673B4B71C830D0" modified="2018-01-31" version="1">MTGQIDRERHGRTVRHVRVAVIGAGFGGLGAAVRLRREGITDFVVLERAGAIGGTWRDNTYPGCACDVPSHLYSFSFAPNPEWPRAFSGQPHIRAYLEQVADTFGLRPHIRLNCEVRSLKWDTERLHWEIGAADGDYTADVVVSATGPLSDHRIPDVPGLADFPGKVFHSSRWDHGYDLRGKRVAVVGTGASAIQIVPGIQPEVARLTLFQRTPPWVLPRADRAITAAEQWLHSRVPATRAVRRGMLWGARELQVGLFTKWPDRLGALERWAASHLRKAVKDPALRAKLLPDYRIGCKRILLSNDYYPALTRPNVDVVASGLAAVRGSTLVAADGTEAEADAIVFGTGFRVTDMPIATRVTGASGTTLAQEWKNGGMAALRGASVPGFPNFLTIIGPNTGLGNSSMILIIEAQLNYLADFLRQLGTIGGRAALDARPSATRAWNRRLQQRMTRTVWNTGCDSWYLDEHGRNTTVWPGSTGEFRKVTRRVDIAEYQVLRAPRVRSAAPVAQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ01</accession>
    <name>A0A2G1XJ01_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_15595</name>
        <name evidence="11" type="ORF">CYQ11_12480</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51180">
        <property type="protein sequence ID" value="PHQ51180"/>
        <property type="gene ID" value="BLA24_15595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13596">
        <property type="protein sequence ID" value="PPT13596"/>
        <property type="gene ID" value="CYQ11_12480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="9">
        <location>
            <begin position="229"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="454" mass="46424" checksum="6D2469B22E79D25E" modified="2018-01-31" version="1">MSSSTVGAAADRDGRNGPEGRGSRDGRAGRDGADRVWSVDEHLRDVLATIRPLEPIELQLLDAQGCVLVEDVTVPAALPPFDNSSMDGYAVRVADVQGASEEFPAVLTVVGDIAAGSAELPPVGPGEAVRIMTGAPLPPGAEAVVPVEWTDGGTGGGPATAMTARREPLGEVRVHRPATARAHVRARGSDVGAGEIALSAGTVLGPPQIGLLAAVGRATVTVRPRPRVVVLSTGSELVPPGEGLAAGQIHDSNSFMLTACARDAGAIAYRVGAVGDDPATLRATLEDQLIRADAVVTSGGVSVGAYDVVKEALSGLPADEGSVDFRRLAMQPGKPQGFGRIGPDRTPLFALPGNPVSSYVSFELFVRPAVRALMGLAPADRTTVRAVCPEGVGSSPEGKRQYLRGHYADEAVHTVGGAGSHLVKALAHANALIVVPEDATSVEAGAEVDVVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ26</accession>
    <name>A0A2G1XJ26_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF501 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16030</name>
        <name evidence="2" type="ORF">CYQ11_12045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51258">
        <property type="protein sequence ID" value="PHQ51258"/>
        <property type="gene ID" value="BLA24_16030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13516">
        <property type="protein sequence ID" value="PPT13516"/>
        <property type="gene ID" value="CYQ11_12045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19219" checksum="14241D3C6AC297F4" modified="2018-01-31" version="1">MDTPPPKTEPTEPTDADIAAFKEQLGRPPRGLRAIAHRCPCGHPDVVETAPRLEDGTPFPTLFYLTCPRAASAIGTLEAEGVMKEMNARLQSDPELAAAYRAAHEDYIRRRDAIEVLEGFPSAGGMPDRVKCLHVLVGHSLAAGPGVNPLGDEAIAMLPEWWRKGPCVSPCGGSGEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJH2</accession>
    <name>A0A2G1XJH2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16225</name>
        <name evidence="2" type="ORF">CYQ11_11850</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51289">
        <property type="protein sequence ID" value="PHQ51289"/>
        <property type="gene ID" value="BLA24_16225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13486">
        <property type="protein sequence ID" value="PPT13486"/>
        <property type="gene ID" value="CYQ11_11850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="396" mass="42845" checksum="0414AF2955BE2739" modified="2018-01-31" version="1">MRADHLVRARELLAAHPVVDGHNDLPWALREQVRYDLGKRDIATDQSADLHTDLPRLREGGVGAQFWSVYVRSDLAGDDAVSATLEQIDVVRRLAERYPADLRLAFTADDMEAARAEGRIASLMGAEGGHSINCSLATLRALHRLGVRYMTLTHNDNIPWADSATDEPAAGGLTRFGEEVVREMNRVGMLVDLSHVSADTMRDALRVSEAPVIFSHSSARAVCDHPRNIPDDVLARLAAGGGVAMATFVPKFILPEAIAWTRAADENMRANGLHPLDTTAVGMAVHRAFEAANPRPRATVATVADHLDHMREVAGVDHVGLGGDYDGTAFTPEGLSDVSGYPNLIAELLRRGWSDSDLAKLTWQNAVRVLRAAEDVAGELSARRGPSIATIDELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJJ4</accession>
    <name>A0A2G1XJJ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gap</name>
        <name evidence="7" type="ORF">BLA24_13740</name>
        <name evidence="8" type="ORF">CYQ11_01435</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51396">
        <property type="protein sequence ID" value="PHQ51396"/>
        <property type="gene ID" value="BLA24_13740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11736">
        <property type="protein sequence ID" value="PPT11736"/>
        <property type="gene ID" value="CYQ11_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="6">
        <location>
            <begin position="129"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="481" mass="52267" checksum="7148A45F4F329DC3" modified="2018-01-31" version="1">MTVNDDSFTDWKTREEIAESMIPIIGKLHREQDVTVLLHSRSLVNKSVVSILKTHRFARQIAGEELSVTETLPFLQALTGLDLGPSQIDIGMLAATYKADDRGLSVEAFTAQAVAGATGENKIECREGRDVVLYGFGRIGRLVARLLIEKSGSGNGLRLRAIVVRQGGDQDIVKRASLLRRDSIHGQFQGTITVDEANDTIIANGNAIKVIYAGDPSEVDYTAYGIKNAILIDNTGKWRDREGLSKHLRPGIDKVVLTAPGKGDVPNIVHGVNHDMIKPDEQVISCASCTTNAIVPPLKAMDDEYGVLRGHVETVHSFTNDQNLLDNYHKADRRGRSAPLNMVITETGAASAVAKALPDLKAPITGSSIRVPVPDVSIAILSLRLGRETTREEVLDYLRNVSLTSPLKRQIDFTTAPDAVSSDFIGSRHASIVDAGATKVDGDNAILYLWYDNEFGYSCQVIRVVQYVSGVEYPTFPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJS4</accession>
    <name>A0A2G1XJS4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13260</name>
        <name evidence="3" type="ORF">CYQ11_00980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51477">
        <property type="protein sequence ID" value="PHQ51477"/>
        <property type="gene ID" value="BLA24_13260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11659">
        <property type="protein sequence ID" value="PPT11659"/>
        <property type="gene ID" value="CYQ11_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="28370" checksum="B31F5B38841C4A55" modified="2018-01-31" version="1">MATITVDGARVHYEKTGTGPALVLVHGTGSSGAAVNWGQTAPRFTGHRTVITPDLSGTEATVDDGAPLTAEGLAAQVIAVIEAAADGPVDLLGFSMGATVSATVAALRPDLVRRLILTAGWAHTDGDEYLRSFFTLWQNLGTNDPESFGRAVAMTGFSRGFLNSIGRDAFEALIPNMPPTVGTLRHIAYDLRVDIRHLLPRIEAPTLVLGGTQDITVPVEHSRALHAAIPNSTYAEIDAGHVMFFEQEDTFVKLVTDFIDDHASPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJY0</accession>
    <name>A0A2G1XJY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superinfection immunity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13285</name>
        <name evidence="3" type="ORF">CYQ11_01005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51481">
        <property type="protein sequence ID" value="PHQ51481"/>
        <property type="gene ID" value="BLA24_13285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11663">
        <property type="protein sequence ID" value="PPT11663"/>
        <property type="gene ID" value="CYQ11_01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016410">
        <property type="entry name" value="Phage_imm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14373">
        <property type="entry name" value="Imm_superinfect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7641" checksum="E0821ACEB5DAE649" modified="2018-01-31" version="1">MFSNIGPFEAVALGVVIMALYVVPSVIAFRRRHPQRLLVLAVNLVFGCTLVGWAVALHLATRSAPARSQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK02</accession>
    <name>A0A2G1XK02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12695</name>
        <name evidence="5" type="ORF">CYQ11_17050</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51557">
        <property type="protein sequence ID" value="PHQ51557"/>
        <property type="gene ID" value="BLA24_12695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14347">
        <property type="protein sequence ID" value="PPT14347"/>
        <property type="gene ID" value="CYQ11_17050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304692" evidence="3">
        <location>
            <begin position="33"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="465" mass="46391" checksum="DE55D2C6A0673ABD" modified="2018-01-31" version="1">MPGRHRPRAHCALAVVVAVQMAVTALASRAVAAPSPPPGPTPTPTPTPSAGTPGVTPGPSASKGNDPCDLIVGLAKDYCQGKKGDGKGTTTSPNDPQSAIDPLANIAKGCADAAAWIIRKLAEAVRATGTVDFTNTTFLRQYAVVFAASTILTLVLWLLAVAKRAVRGVPFTEAFTEAVGFLWLTVLASAFTPLILYTVVSATDAVTDVIASASGSSANNDAFFGGFADALQKGGGSGIGGGPIMLVVVSLVSVLAAGILWLELVIRAALLYVGALLGTAVYAGLVDKNMWGHVRRWAGIMIAVILVKPIIMIVLGLAGALSSGSGPNAFSAVVSGLAIIILAILASAMIYRFVPGFGDEIVSTRNASQDAASRQAAAVISSPAALVKQGITTHSARGDSGGGGGGGAQPARPASPVAGGVAAHSTRPSAAPAPGPAPAAPAQAPAPAPRAQKNSKSNASGGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK61</accession>
    <name>A0A2G1XK61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51625">
        <property type="protein sequence ID" value="PHQ51625"/>
        <property type="gene ID" value="BLA24_13105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="71" mass="7530" checksum="0906C6AF09796A7F" modified="2018-01-31" version="1">MYRFRPAPALWLIVGGCLLIAQHDLLRSRARAQTYMGYAVPHWPACALVTLFFLAVAAIALAGRGACGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK64</accession>
    <name>A0A2G1XK64_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2993 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12950</name>
        <name evidence="4" type="ORF">CYQ11_17310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51600">
        <property type="protein sequence ID" value="PHQ51600"/>
        <property type="gene ID" value="BLA24_12950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14393">
        <property type="protein sequence ID" value="PPT14393"/>
        <property type="gene ID" value="CYQ11_17310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="416" mass="45012" checksum="176121F2FF544442" modified="2018-01-31" version="1">MRTPTRIPSLPPNPYEELASLADPEPEPTPPDTPPGAPPLTVHIAPAHVVADEPWSPPDHRRPRKRSRRTRRARRSPARRPRLLVPRLLAAALGATALLLLADRCAAMYAEKKAQQALRQQLHLAADPQVDIRGFPFLTQVLAKRLHRVDVTVPDVDADRVSLAKVRASARDVRITGSVPAGVRGATVGQLKGDVLLSFADMNRELGSSQIKFSDLGDDAVAARGRVGIAGQQVLLRARAHLRRDGDRAVSTEVDSMSLDLPHLATYRPEGKDKSLVLHREAAERISRDAGRAKALLAVPAIAARLGVTEEEAAAALHSEQRLRGIVGSPRFVDRLTRANLVDVVVAHPWILERLGVDPAVVAGLAHVRPPELADRLTLSFRLPPQAKDLHLRGVVVERDGIRADLSATGLSVGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK75</accession>
    <name>A0A2G1XK75_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12555</name>
        <name evidence="3" type="ORF">CYQ11_17480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51654">
        <property type="protein sequence ID" value="PHQ51654"/>
        <property type="gene ID" value="BLA24_12555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14421">
        <property type="protein sequence ID" value="PPT14421"/>
        <property type="gene ID" value="CYQ11_17480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="26295" checksum="68827298B983AD6B" modified="2018-01-31" version="1">MTGTQSHPYPAQAVILAGGQGSRLRPYTDDRPKPMVEIPGTGVPIIGHQLAWLASEGVTDAVVSCGHLAEVLQEWLVSADLPLRVTTVVEKEPLGRGGGLKFAASSLPRPDEPWYATNGDIWTRFSLREMAAFHAERDATATLALARPRIPWGAVETDEFGKVLDFIESPPSPYLINAGVYVFSPGFLELLPERGDHERTTFPRLARERRLAGFPLPQGAYWRAIDTAKDLTEAAKELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK90</accession>
    <name>A0A2G1XK90_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">BLA24_12845</name>
        <name evidence="3" type="ORF">CYQ11_17200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51630">
        <property type="protein sequence ID" value="PHQ51630"/>
        <property type="gene ID" value="BLA24_12845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16619">
        <property type="protein sequence ID" value="PPT16619"/>
        <property type="gene ID" value="CYQ11_17200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="141" mass="14907" checksum="7546B9FC57C4D5E4" modified="2018-01-31" version="1">MRAVVQRVDGASVAVDGRVVGEIIGEGLCVLVGVTHDDTPQKAAQLARKLWSLRVLEEEKSCSDVGAPLLVISQFTLYGDARKGRRPTWNAAAPGAVAEPLVDEVVAALRALGARVETGRFGADMKVSLTNNGPFTVLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK99</accession>
    <name>A0A2G1XK99_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">BLA24_12570</name>
        <name evidence="14" type="ORF">CYQ11_17465</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51657">
        <property type="protein sequence ID" value="PHQ51657"/>
        <property type="gene ID" value="BLA24_12570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14418">
        <property type="protein sequence ID" value="PPT14418"/>
        <property type="gene ID" value="CYQ11_17465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="340"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="463" mass="51554" checksum="0F201F00ADC026D1" modified="2018-01-31" version="1">MTIRLYDTNARQIRDFSPLTPGCVSIYLCGATVQAAPHIGHIRSYLNFDIMRRWFIHRGYDVTFVRNVTDIDDKIIAKAADQKRPWWAIGYENERAFNSGYDALGCLPPTVEPRATGHVTEMVEMMRGLIERGHAYAADGNVYFDVRSFPGYLELSNQELDNLLQPSGEGETGKRDPRDFAMWKAAKPGEPSWETPWGRGRPGWHLECSAMAHKYLGEAFDIHGGGLDLIFPHHENEIAQAKAFGDDFASYWVHNAWVTMSGEKMSKSLGNSVLVSEMVKHWRPIVLRYYLGTPHYRSMIEYSEEALREAESAFARIEGFIQRVVELAGPVEPAAEVPPAFAEAMDDDMGVPQALAIVHTTVRQGNAALTADDKEAAVARLAEVRAMLGVLGLDPLAEQWVDAGAGREDLHGVVDSLVRLVLEQREAARGRKDYATADAIRDQLQQSGLAIEDTPSGPRWSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKA2</accession>
    <name>A0A2G1XKA2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12490</name>
        <name evidence="3" type="ORF">CYQ11_17545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51662">
        <property type="protein sequence ID" value="PHQ51662"/>
        <property type="gene ID" value="BLA24_12490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16627">
        <property type="protein sequence ID" value="PPT16627"/>
        <property type="gene ID" value="CYQ11_17545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="163" mass="16985" checksum="1DBE5D60524511F6" modified="2018-01-31" version="1">MKLAWASGGTFAGVTGAEMIEKSKENGASGLWLTLEGWGLDPTALLAALGVFLLFGLVRPWGQVFPRWTLLLAGRRVPRWLPLTPALIGAGTLAPYGVAGVCGAALGTAGVLHVPKGDFPSPADVLLVSWIGLGAFAVYGVALALAARSYWVRTRARCAENLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKA4</accession>
    <name>A0A2G1XKA4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="13" type="ORF">BLA24_13010</name>
        <name evidence="14" type="ORF">CYQ11_17370</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51611">
        <property type="protein sequence ID" value="PHQ51611"/>
        <property type="gene ID" value="BLA24_13010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14404">
        <property type="protein sequence ID" value="PPT14404"/>
        <property type="gene ID" value="CYQ11_17370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="109"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="226"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="429"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="602"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="791" mass="87425" checksum="F77567F3CF5187A2" modified="2018-01-31" version="1">MQPAAPHATARRLRAAPAPPSDAPAPAVARNNEGMSQSTGTGAQAYDSVRAHDSTEAVGFIAAHRPKAAVIAGMPEAPVPELDAYAPGPGPEAGPEAPPEADPLPEGRFLDRERSWLAFNERVLELAEDPATPLLERANFLAIFASNLDEFFMVRVAGLKRRIATGVATRSASGLQPREVLELIWTRSRELMARHAACYQHDVAPELADQGVHLIRWPELTGQEQGRLFTLFRQQIFPVLTPLAVDPAHPFPYISGLSLNLAVVVRNPVSGHDHFARVKVPPLLPRFLEASPQRYVPVEDVIAAHLEELFPGMEVLAHHMFRVTRNEDLEVEEDDAENLLQALEKELMRRRFGPPVRLEVEETIDPYVLDLLVRELKISDAEVYPLPGPLDLTALFAIAALDRPELKYPKFVAGTHRDLAEVESASAPDIFAALRERDVLLHHPYDSFSTSVQAFLEQAAADPDVLAIKQTLYRTSGDSPIVDALIDAAESGKQVLVLVEIKARFDEQANIKWARKLEEAGCHVVYGLVGLKTHCKLSLVVRQEGDTLRRYSHVGTGNYHPKTARLYEDFGLLTADPQVGADLSDLFNRLSGYSRRETYRRLLVAPRSLRDGLVSRIAKEAAHHRAGRPAYVRIKVNSMVDEAVIDALYRAARAGVPVDVWVRGICALRPGVPGLSENIRVRSVLGRFLEHSRVFAFGNGGEPEVWLGSADMMHRNLDRRIEALVRVTDPGHRASLSRLLELGVSDRTAAWHLGPDGNWTRHATDADGQPLPNVQEMLVDARRRRRGSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKC0</accession>
    <name>A0A2G1XKC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12865</name>
        <name evidence="6" type="ORF">CYQ11_17220</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51631">
        <property type="protein sequence ID" value="PHQ51631"/>
        <property type="gene ID" value="BLA24_12865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16620">
        <property type="protein sequence ID" value="PPT16620"/>
        <property type="gene ID" value="CYQ11_17220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="256" mass="26772" checksum="080657A69D2610EC" modified="2018-01-31" version="1">MMRLDVEGLTVDIGGARLVEDIALRAGSGRFVGVVGPNGSGKSTLLRCVYRALRPVAGRVLLDGEDLRGLSAREGARRIAALPQESAGEFDFTAAEVVAMGRLPHQSAAGRTTAADTEACATALTRVGAAHLAGRGFLTLSGGEKQRVLIARALAQQPKVLVLDEPTNHLDIAQQLEVLSLVRDSGLTVLAALHDLNLAATHCDELYVVAGGRVVASGPPHSVLTAELLAEVFGVRAHRVPHPASGAPQLLFDRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKI0</accession>
    <name>A0A2G1XKI0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3492 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11815</name>
        <name evidence="3" type="ORF">CYQ11_03055</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51764">
        <property type="protein sequence ID" value="PHQ51764"/>
        <property type="gene ID" value="BLA24_11815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12011">
        <property type="protein sequence ID" value="PPT12011"/>
        <property type="gene ID" value="CYQ11_03055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3492" evidence="1">
        <location>
            <begin position="14"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="505" mass="54861" checksum="9CC18A71057733B0" modified="2018-01-31" version="1">MHGPSAQPVSAAPSVTLLTEGTYPHSHGGVSVWCDQLVQGMPDIDFRVIAVTGTGREQLAWQLPGHVRQVDSVPLWGPPAPGRAPRGRRLRRFLTCYEQFLEALLDPAREPHFARGLYRLSDHAADGTLSAALRDEPAARLLARLWNRPHLATAAARPTLRDALTATDLLEHALRPLAARVPAEGITHAVSGGLATLPGLVAHHRHGTPFLLTEHGIYLRERYLSFRAEPYRWPVKALMLGLFRLLALESYRRAALVTPGNRYNRRWEEHGGTPPERIRTVYNGVDPAAFPPAGPEPDVPTLSWAGRVDPIKGLETLIRAFALVRKEIPDARLRLFGGTPRGGEGYRTACEALAAELGAADAVTFEGRVEDIRDAYAAGNVVMLSSISEGFPFTLIEAMSCGRATVSTDVGGVREAVGDSGLVVPPRDPQSMARAALRLLRDPGLRATMGESARLRVVEQFTLRQTISAFRDIYHDLARRRQPVPLSVTVPQPVPVMALAAGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKI6</accession>
    <name>A0A2G1XKI6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11390</name>
        <name evidence="3" type="ORF">CYQ11_02625</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51691">
        <property type="protein sequence ID" value="PHQ51691"/>
        <property type="gene ID" value="BLA24_11390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11940">
        <property type="protein sequence ID" value="PPT11940"/>
        <property type="gene ID" value="CYQ11_02625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="343" mass="36096" checksum="6E9AF548C95623C9" modified="2018-01-31" version="1">MTTSSPAPGPRTPDAPGDDKTLRVLSTSDLAQIDISLADVVATVENAYRTLAAGRSDNPRKLTVKPPDGHSVSYAMLGRDGSREVVAIKTSYKHGLDRERDGQHYYTALTLYDDVTGLPVAMMDCGRIGALRTPAASALLARECARPGARSALVVGTGTQGRLALPFLLTTLPALDRLMLFGTRPEGVEAVRAELRRHFPGREAEVVTDLRAAAGAADVVVATAGPHTPAAVDASWLAPGSLSILVGHGLAPSTLHRADRVVATSEAQMRVTGTDMADAEGRLPAVDAEFPAVLAGLAQGRRSPDEHVFAYNSGLVVTDIALGHRLAQLAIAEGRGTRVPLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKM4</accession>
    <name>A0A2G1XKM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11920</name>
        <name evidence="3" type="ORF">CYQ11_03160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51782">
        <property type="protein sequence ID" value="PHQ51782"/>
        <property type="gene ID" value="BLA24_11920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12029">
        <property type="protein sequence ID" value="PPT12029"/>
        <property type="gene ID" value="CYQ11_03160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="26313" checksum="106CE66D82DD9F36" modified="2018-01-31" version="1">MNSVSVRTLLVRGMLAGLATGVLALITAYLLGEPHVDSAIAFEEAHSHDHGDGVELVSRTLQSTGGLATGILVYGVALGGIAALAFCVALGRVGRFGPRATAALVALGAFVAVFLVPFLKYPANPPAVGDPDTLDKRTALFFLMIALSVLLTVATVILGRRLAPRLGNWYATVVAGLALVVVLGLAFAFLPSGDNVPEGFPATLLWEFRLSSLATELVLWTGFGLIFGELAERALVPKAGRAAPERDTEPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKV9</accession>
    <name>A0A2G1XKV9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">BLA24_11110</name>
        <name evidence="8" type="ORF">CYQ11_16825</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51878">
        <property type="protein sequence ID" value="PHQ51878"/>
        <property type="gene ID" value="BLA24_11110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14307">
        <property type="protein sequence ID" value="PPT14307"/>
        <property type="gene ID" value="CYQ11_16825"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="28236" checksum="599504EB6E04E1CF" modified="2018-01-31" version="1">MLLTIDVGNTQTVLGLFDGEDIVEHWRISTDPRRTADELAVLLQGLMGRHPLLGDELGDGIEGICICSTVPSVLHEMREVTRRYYGDVPAILVEPGVKTGVPILMDNPKEVGADRIINAVAAVELYGGPCVVVDFGTATTFDAVSARGEYVGGVIAPGIEISTEALGVRGAQLRKIEIARPRSVIGKNTVEAMQSGILYGFAGQVDGVVNRMARELADDPDDVTVIATGGLAPLVLGEASVIDEHEPWLTLVGLRLVYERNVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL38</accession>
    <name>A0A2G1XL38_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_10915</name>
        <name evidence="8" type="ORF">CYQ11_00635</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51958">
        <property type="protein sequence ID" value="PHQ51958"/>
        <property type="gene ID" value="BLA24_10915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16265">
        <property type="protein sequence ID" value="PPT16265"/>
        <property type="gene ID" value="CYQ11_00635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="51542" checksum="F2765AA11C15F6A7" modified="2018-01-31" version="1">MLQEALSIEGVHRWRWWALITLLVAEAMNLLDSTIVTVAAPVIHADLGGPASEVQWFNAAYTLPFAVFLITGGRLGDLAGRRRMFTAGVTGFAVASLACALAPSAGLLIGMRAVQGAAAALIIPQTIGLIRSMFDGAELAKAMGSIGPVMGLAAVLGPVLGAFLTHADLFGSSWRAVFLVNLPLAVAVLAMVPLLPGRNAAATARPLRLDGVGTALAVLATTLIVYPLIQSSTVGWPAWSWVALAAGCGLLGLFGLHQQRRSRAGRSPLVEVSLFHDRGFPAALATSTLFFAVMNGLMLVIVLQVQLGLGRGVLAAGLTLLPWSAAMALSSWMAGTRLVPRHGRNVMFAGLAVMCAGLIAATIAYRTTPPHTYPWPLLGALAAAGIGNGLFTVPFFTTALSRVRPHETGSAAGLLNAAQQLGATLGTAVLGTTFLHTLDAGTEPAGSSLAAAQLAFWIAAGLLGLTAVTALAMLGRHLPAPDGDERPLQRLTGASHDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLA7</accession>
    <name>A0A2G1XLA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10725</name>
        <name evidence="3" type="ORF">CYQ11_00825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51919">
        <property type="protein sequence ID" value="PHQ51919"/>
        <property type="gene ID" value="BLA24_10725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11636">
        <property type="protein sequence ID" value="PPT11636"/>
        <property type="gene ID" value="CYQ11_00825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13646" checksum="D353714852907A3E" modified="2018-01-31" version="1">MACRISELVIDCADPDRLAAFWSEVLGYVELGREDDGSIEIGPPDTGFGGPQPTLVLSPSSAPRTGKLRLHIDVNATDREQGAELDRLLALGARPADAGQTGTESWHVLADPEGNEFCLLHTRLKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLF7</accession>
    <name>A0A2G1XLF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000106">
        <property type="protein sequence ID" value="PHQ52011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52011">
        <property type="protein sequence ID" value="PHQ52011"/>
        <property type="gene ID" value="BLA24_10080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="279" mass="30563" checksum="0E9493372C5986E9" modified="2018-01-31" version="1">MRDFDTARHYGRRAVSLAGTTGDDGLVSRRRTILLQIEVRDPGRRTPLSRLRDECRALATAFTHDNDRESLFAVRLAEAESYLQERWYVHAAKLYGELLDRIRVEGGIRTETECRCRLAETLLATGDTAAALEHASQALSGALLAQENLLMARSHRILGSALRAVGDTAATEHLAEAASLQSELGLGLRALTCLPEEDLRADRGRPLRGLEHARLRGQPRSADLVATSAVLRPFAGAPGGDDRPQPGQVAGLGQFAVEPRDRVHTHRSRHMGPPRLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLJ2</accession>
    <name>A0A2G1XLJ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">BLA24_09175</name>
        <name evidence="5" type="ORF">CYQ11_27785</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52087">
        <property type="protein sequence ID" value="PHQ52087"/>
        <property type="gene ID" value="BLA24_09175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16167">
        <property type="protein sequence ID" value="PPT16167"/>
        <property type="gene ID" value="CYQ11_27785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="27184" checksum="012E264521E695CC" modified="2018-01-31" version="1">MTITQVPPPTAAPPIGLRAKARIVAAPDGRGGTALPVLAGDGPLALRRLRPCGRQARVCLVGAMSAPLGGDVLGLSADVRDGAALRLQSAAATLALPGRTGEPAFYDTRLTVGDGAELRWLPEPLISVRGSDLRQTTRADLAPGARLVLREEQVLGRAGEPPGRLVTRLTVRRAGRPLLDQELRSGPGTPGWDGAAVLGGHRAVGQLLVVDAGFADRPVAARALGATASLTPLAGPAVLVGAVAPDALSLRRVLDSVLREMDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLK0</accession>
    <name>A0A2G1XLK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09250</name>
        <name evidence="4" type="ORF">CYQ11_27860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52100">
        <property type="protein sequence ID" value="PHQ52100"/>
        <property type="gene ID" value="BLA24_09250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16180">
        <property type="protein sequence ID" value="PPT16180"/>
        <property type="gene ID" value="CYQ11_27860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="722" mass="77356" checksum="76D05830C4C13250" modified="2018-01-31" version="1">MPGRIPRRRVLQIAGGTAVVGAGAVGTWQWLAPEDKGRPGSGEFPARPAKAVTSEAVVHVMAHEDDSLFFMNPELEQSIRSGAPTLTVCMTGGESDGRNALSTEPGYDKLPMKRPEFVRARMNGLREATAQMATGDWLSPWTVETLRLLPGLEVELQTLKAAPQIQLIFMELVEARAIKNPKKESLRGLWLGAAPDLTTLVPAGGPVRKAYRYTRQQVIDTLTAVFERYQPTVVRTLDPNPTHRAKQPEFPGTPPVLQGISHYDHQDHTASAYFAQAALAQFWGRKHSRPVAVDTYVGYEVDMLPNSLDDATTAHKIKILDTYGWVGDKDCGDKAGCGDRKVGNRGRDYRWSNNLRHRATGTQRWVQPLPDGRLAAFAVLDGQAQCWTETKAGSGVWSQPASVGGSMLEGQVQVLRRSDGSLQLFSVRTVLPAKGEDHRREIVTARQEGKTPDGGTPAFAAWESLGSPDADPERSMETGYPVAVEDKDGSVHVFVKNFDGGVSFRSSASGQGWRDWAALPAVAGDVRIEDGIDVALDNQGRIHVVAADTKTVHHWVSEPGDAAPKPAGATRLPAATGPLTLTPLSGGGIRLAMRQPVTSRVVVADLAAGGGWRVTSECEAFGGYGRVALAQVENTTVIAARDDKGRVRLSVGSGRPGPWQDGGVPHRATAALAQDAQGRTVVVALGTDGRLSSTRGAGSGSSSFGDWIGHDGQVRKGDTQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLK8</accession>
    <name>A0A2G1XLK8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09730</name>
        <name evidence="2" type="ORF">BLA24_09745</name>
        <name evidence="3" type="ORF">CYQ11_02155</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000099">
        <property type="protein sequence ID" value="PHQ52061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000099">
        <property type="protein sequence ID" value="PHQ52062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52061">
        <property type="protein sequence ID" value="PHQ52061"/>
        <property type="gene ID" value="BLA24_09730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52062">
        <property type="protein sequence ID" value="PHQ52062"/>
        <property type="gene ID" value="BLA24_09745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11857">
        <property type="protein sequence ID" value="PPT11857"/>
        <property type="gene ID" value="CYQ11_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="122" mass="13539" checksum="91F784EC7C74E0F7" modified="2018-01-31" version="1">MAADPQPVRRRRTRLYALTDGRTTASRHGLTMDTVITAVADPGHGHGSLPTEWQEILAMCPSPNGRAVAELAARMRMRLTPMTVLLGELLERGLIRHRPPLDASETSNVHLLMKIRDNLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLN4</accession>
    <name>A0A2G1XLN4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_09460</name>
        <name evidence="5" type="ORF">CYQ11_28070</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52137">
        <property type="protein sequence ID" value="PHQ52137"/>
        <property type="gene ID" value="BLA24_09460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16217">
        <property type="protein sequence ID" value="PPT16217"/>
        <property type="gene ID" value="CYQ11_28070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="33235" checksum="3D54E0EF63CA68EA" modified="2018-01-31" version="1">MSPMSPREASSRPVVRTVLGDVPAEELGVCDAHDHLFLRSPLLPGRELDDPGAAEAELRAFAGLGGRAVVQWTPRGMGRRRAHLARLARATGVHLVAATGLHQAAHYDEALLERSWDRLAELFVDDLTTAPVRAGLVKVAGAFHGLDRHARHVMTAAAHAHHATGAPVAVHLELGTGALDVLDLLCDGHGVPPTSVVLGHLGRSPDVRAQLAAARAGAFLAFDGPSRAHHATDWRLFDSLAALADAGHADRLLLGGDTTTRAARAAGGEGPGMPYLLSGLRPRLARELGEDFVQRVFVDNPARAFAAPWRPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLU2</accession>
    <name>A0A2G1XLU2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52197">
        <property type="protein sequence ID" value="PHQ52197"/>
        <property type="gene ID" value="BLA24_08485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="140" mass="14320" checksum="F07B248DBE366DC6" modified="2018-01-31" version="1">MERFGAGRGRRDPARALPGQAERCPDATAITFEGVELSYGELDARANRLARLLVSRGVGAESLVAVCMERSAELVVALLAVVKAGGAYVPVDPEYPVEAHGVCARGCCSGAGGDQWCGRGEVAVGGRSGAGGGRRCRCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY3</accession>
    <name>A0A2G1XLY3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08620</name>
        <name evidence="3" type="ORF">CYQ11_03875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52220">
        <property type="protein sequence ID" value="PHQ52220"/>
        <property type="gene ID" value="BLA24_08620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12153">
        <property type="protein sequence ID" value="PPT12153"/>
        <property type="gene ID" value="CYQ11_03875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="337" mass="32820" checksum="2B790AB1241DB0D5" modified="2018-01-31" version="1">MDTDPGDAVRPDSGDCARPPSGDLVAALDIGGTKIAGALVAGDGRLLVRARRATPAREDGATVMGAVAAVLGELLRSPLWPRVRAVGIGSAGPVDAVAGTVSPVNVPGWRGFPLVAEVARHTGGLPVVLVGDGVAMTAAEHWQGAARGRDNALCMVVSTGVGGGLVLGGRLHAGPTGNAGHIGHISVDLDGAPCPCGARGCVERIASGPNIARRAVADGWRPGPDGDASAEAVAVAARAGDPVALASFARAAQALAAGIAATAALVEIEVAVIGGGVAGAGDVLFGPLRSRLRDYATLSFASGVEVLPARLGSDAGLVGAAAAAAGSVELWGTSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM05</accession>
    <name>A0A2G1XM05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08760</name>
        <name evidence="3" type="ORF">CYQ11_04020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52285">
        <property type="protein sequence ID" value="PHQ52285"/>
        <property type="gene ID" value="BLA24_08760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16340">
        <property type="protein sequence ID" value="PPT16340"/>
        <property type="gene ID" value="CYQ11_04020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="1">
        <location>
            <begin position="106"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="30571" checksum="4CEBC1B4E4EB3BE1" modified="2018-01-31" version="1">MLARRVEALPEADALPGGSVYEPKFDGWRLVVLRTADEVLLQTRNGRMVTATFPEIASAAAALPAGTVLDGEVVVFTGGRVDFSALQHRALGAESPRRRRAPGPPVNLAAFDLLAVSGTDLRPRPYEDRRALLVTLLAPLGPAIQAVPVTYDRAEAAGWYEHLVETGIEGLVVKGRAQSYQPGRRRWLKLRHAAPRDALAVGWTGPRTRPRALVVDLGEGPALSAPLSPTVSRDLAAFTRTGEGAAGVLDDGTRYRSLDRPLPVEVRQGADRHALITVTRLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM26</accession>
    <name>A0A2G1XM26_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08785</name>
        <name evidence="3" type="ORF">CYQ11_04045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52287">
        <property type="protein sequence ID" value="PHQ52287"/>
        <property type="gene ID" value="BLA24_08785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16342">
        <property type="protein sequence ID" value="PPT16342"/>
        <property type="gene ID" value="CYQ11_04045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="128" mass="13328" checksum="CE443307A2348F40" modified="2018-01-31" version="1">MDWMLKDLASSVPQTRHVIVLSSDGLRMAQHGSDTDAADRLAAACAGLQSLSTAIAAEFPGGDGKMRLVVIEVDGGFFYLMAAGAGAYLAVLADDDVDAGLMGQRMRDLVARIGEHLTSPPRVSGPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMA5</accession>
    <name>A0A2G1XMA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08045</name>
        <name evidence="2" type="ORF">CYQ11_00485</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52385">
        <property type="protein sequence ID" value="PHQ52385"/>
        <property type="gene ID" value="BLA24_08045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11587">
        <property type="protein sequence ID" value="PPT11587"/>
        <property type="gene ID" value="CYQ11_00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="185" mass="20657" checksum="EBD36F2FE2D975B8" modified="2018-01-31" version="1">MVTVGEGLDKAVQGAFTRPAPKSAGAQMRYLVKQHKHSTKAVAQLLGITQRTVERYVKDQIKKPRSDLAARMEHEVKQRWQPQIRAKAKHTAATTGGIMIDTRARFGFTAAPGTTDDARLRHLTLALPPTHAARLFEAQERGATENQLRQIAAEALGEVYFRDDGRRAHGLEVRLTDVEHLEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XME3</accession>
    <name>A0A2G1XME3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2278 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07995</name>
        <name evidence="3" type="ORF">CYQ11_00430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52380">
        <property type="protein sequence ID" value="PHQ52380"/>
        <property type="gene ID" value="BLA24_07995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11582">
        <property type="protein sequence ID" value="PPT11582"/>
        <property type="gene ID" value="CYQ11_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="1">
        <location>
            <begin position="219"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="335" mass="36108" checksum="40E95B7A25F21498" modified="2018-01-31" version="1">MPIARYGVLACRAVERRREGSAETPHYQIHLLDNSGTHYRAAVNVLSQQAPSELLYAADDDFRHPLTAALPPAGSGWTPLPSERGGAALDFIRGNMFVPASMRTLPPDLPGVDNDLADLLDHYVERAVADPTTALYLFGQRFGPEPGKPDATFGFRPGNGVHDIHMNQGNVGRFRNDDGVWQDGALLFHLPVESRWTAIFLAFQSQAWHTDDVTGHALPTPALRPSVRDAPLRVVGVRTDGFPATAPAESVTLLNASPEPLELTGWQLADAHGNLLALPAQILAPGDTATVSDGDGFHLDKSGGAVTLLDPGGLKVHGVAYTGQQRRREGWMITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMI4</accession>
    <name>A0A2G1XMI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08000</name>
        <name evidence="4" type="ORF">CYQ11_00435</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52381">
        <property type="protein sequence ID" value="PHQ52381"/>
        <property type="gene ID" value="BLA24_08000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11583">
        <property type="protein sequence ID" value="PPT11583"/>
        <property type="gene ID" value="CYQ11_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="37146" checksum="7FE316B0D3150F7E" modified="2018-01-31" version="1">MTVVRVGTFNLNNLFSRFNFQTEIDAVHTAAGSDGGELAVSYEFNDPHRFKIRTYKGRLVKGKDPEDQKLIAGRILAMDLDVLAVQEVEDIDTLRFFCTRDLRRLYPHLTLIEGNDRRLIDVALLSKFPLGAVTSWQHAVHPDRPGERVFSRDLLEADVMAPDDRDKRLFTLFNNHLKSQFVEHDQDPVAGKAANDELRRRQAEVAQRIVAARTRPDSRFLVLGDMNDAPAAAPLAPLVNSSGLSLTNALTHPTQTREPKPDDPPPPASGAWTHRFKESGKPAKYELFDQIWLSPALAELQRGAFVDRRTRHAGDGSDHDPAWVELDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN03</accession>
    <name>A0A2G1XN03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_07075</name>
        <name evidence="8" type="ORF">CYQ11_27230</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52529">
        <property type="protein sequence ID" value="PHQ52529"/>
        <property type="gene ID" value="BLA24_07075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16066">
        <property type="protein sequence ID" value="PPT16066"/>
        <property type="gene ID" value="CYQ11_27230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304935" evidence="5">
        <location>
            <begin position="35"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="613"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="648"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="913" mass="95205" checksum="A50C78A32C01D84D" modified="2018-01-31" version="1">MKLRFPRLRGRRLLAATAAAVVLAGAGTWTVASATGGDPPVRREDRFMTVPEAAGGGGGGTVRIDTSFFTSGGSGRRPAVLLAHGFGGSKEDLRSQAEELARSGYAVLTWSARGFGRSTGRIGLNDPDREVADVSRLIDWLAGRPEVRLDAAGDPRVGITGASYGGAVSLLAAGNDKRVDAIAPQITYWNLADSLFPGDVFKKLWAGIFFTTGSTSTTASGPVGPKGGPAGEGGAGAPSALAAGCGRFEKSLCEMYERVAVAGKPDAQARELLERRSPSAVAGRIGVPALLVQGQSDSLFPLDQSDAAARAIDRNGAPVAVDWITGGHDSGTKGEQDRVERRTKAWFDRYLGDDDGVDTGPVFRVTRTGGIDSTNGRTQLRGASGDYYPGLHGDPREVALTGREQSFANPAGATPPAISAVPGIGGISQLSGLGVGVSMDFPGQYARFDSERLDEGVHVTGSPTAKVKVASDTGEAVLFAKVYDVGPNGQQLLPGQLVTPLRVEGAGTGRTVEVRLPAVDHTFEAGHRMRLVLASTDLGYASPARPATYTVSLGDGGLTVPVAPGVRTGSAGLPWWTWAMPLGGVLVAAAVLLTGRRRTAAPAPDPELADVPLQITGLSKRYAGSADRYAVRDLSFRVERGQVLGLLGPNGAGKTTTLRMLMGLIRPDAGEIHVFGHAIRPGAPVLSRVGAFVEGAGFLPHLSGRANLDLYWRATGRPAEDAHLDEALEIAGLGPALERAVRTYSQGMRQRLAIAQAMLGLPDLLILDEPTNGLDPPQIREMREVMIRYAAAGRTVIVSSHLLAEVEQSCTHLVVMDRGRLVSAGPVAEIVGSGDTLLVGVEGEVSEVTADKVAALPGVASAVRTDEGLLVRLDGVRAPELLVELVRLEVPVASVGPHRRLEDAFLTLIGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN05</accession>
    <name>A0A2G1XN05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52608">
        <property type="protein sequence ID" value="PHQ52608"/>
        <property type="gene ID" value="BLA24_07515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA_3" evidence="1">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="228" mass="23837" checksum="8C8FE15690200D57" modified="2018-01-31" version="1" fragment="single">ELTARAARTLLGPSAAERLAALEERTERLLEHNRIARELHDSVGHALTVAVVQAGAARAAGSPEFTERALAAVEETARHALEDLERVLKVLREDAPGPAARPSLMDAGRLLTAARGAGAEVTAEVTGPLEAVPGPLSREGYRIVQEALTNVVRHAGAVPVSVRMAVRPDALELDVRNPLTAGAGTLAGSGSGLRGIRERAALLGGHAETGEHEGCWRVRAVLPLNDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN49</accession>
    <name>A0A2G1XN49_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000080">
        <property type="protein sequence ID" value="PHQ52633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52633">
        <property type="protein sequence ID" value="PHQ52633"/>
        <property type="gene ID" value="BLA24_06415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="2">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="187" mass="20553" checksum="06403FC64C229A2B" modified="2018-01-31" version="1">MYTFGVLKSPLADPARLTQEFYESGEAVYREIGQHPGYIAHAEPAEHSRGALFGSDWGAWGEFAVPAWYGKGRTAETTALAATLSLWTDLGSAIDAVYTGLHRVALNRRHDWFERTGHPSHVSWWVADGAIPTWQDGVTRLEHLHDHGYAPHAFTFHHSFDPAGTPARLKGIGPKGDMSVPDSPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN77</accession>
    <name>A0A2G1XN77_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_06210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52695">
        <property type="protein sequence ID" value="PHQ52695"/>
        <property type="gene ID" value="BLA24_06210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="577"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1683"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1754"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="1813" mass="192847" checksum="85F5773FBFB02C09" modified="2018-01-31" version="1">MCGLVQAAAEGVVAALEGAEKGSSLHRVRVLGEAERERVLAGWNDSALDVADATLPELFRAQAERCPDATAITFEGVELSYGELDARANRLARLLVSRGVGAESLVAVCMERSAELVVALLAVVKAGGAYVPVDPEYPVERMEYVLGDAAPVLVVTSGAAAGKLPSVDGLVRVVVDDAAVVAELAELSGGELGAVERGGVVLPSHPAYVIYTSGSTGRPKGVVVPHQNVVRLFGGTDGWFDFGADDVWTWFHSFAFDFSVWELWGALLHGGRLVVVPHGVSRSPGDFLSLLVRERVTVLNQTPSAFYQLMQADARDPELGAGLALRCVVFGGEALDLGRLREWYARHAEDAPVLVNMYGITETTVHVSYVALDQSSVGEGPVGSLIGRGIPNLRLFVLDEVLEPVPAGVAGELYVAGRQLARGYLGRAALSAERFVACPFGVAGERMYRTGDVVRWRADGQLEFVGRADDQVKIRGFRIELGEIETALISHSSVGQATVLVREDTPGDKRLVAYVVPATADGVDATDVRQHVAGSLPDYMVPAAVLVLDELPLTVNGKLDRRALPAPDFAAAVSGRGPSSVQEEILCGVFAEVLGLPHVGVDDNFFELGGHSLLAVSLVERLRARGMSVSVRTLFTSPTVAGLAAASAGRGEVAVPENLIPAETDVITPEMLPLVELTAEEIERITSGVPGGAANVADVYPLAPLQEGLFFHHLMGSETGKDVYLQQTVLTFDARERLDRFLAALQKVVVRHDILRTAFAWEGLREPVQVVARHAEVPVHEVDLGPDTGAEGAAERLLAACSPSMDIGRAPLLRAYVAAEPGDGTRWLMVLQNHHLVEDHTALELLLGEVRAHLLGQEEHLPVPVPFREFVAQARLGVSREEHEKFFAGLLEGVAEPTAPYGLLDVRGDGTDVGEAVTAVDTVLAERLREQARRLGVSPATLFHVVWARVVAATSGRDDVVFGSVMFGRMQAGSGADRTPGLFINTLPVRVPTGGTSVTDAVRAMQAQLADLLVHEHAPLTLAQQATALPAQTPLFTSLLNYRHNNTAPDRVGEDVNAGLEGIELLSAQERTNYPLTVSVDDSGTGFNVTVQSATPIEPESVCALILTAAEGVTTALEEASVAPLSQVRVLGGAEQELVLTQWNDTARDVPVATLPELLARRVARTPDAVALVFEGVELTYAELDARVNRLARLLISRGVGPESLVAVSMERSVELVVALLAVLKAGGAYVPVDPEYPAERVAYMFRDAGPVLAVTSSAVQDRLPVIEGLATVVVDAPATVTDLAAMADGPVDDTERHTALLPSHPAYVIYTSGSTGRPKGVAVPHRNVVQLFGAAEGRYDFGPDDVWTWFHSFAFDFSVWELWGALLHGGRLVVVPHAVSRTPGEFLKLLVREGVTVLNQTPSAFYQLIQAETQSPDLGAQLALRFVIFGGEALDHGRLGEWYARHPENVPVLVNMYAPTEATVVCTGYGVHAEEEGPAGVLPIGSPMANTRAYVLDDALQPVPVGVAGELYLAGAQLARGYLHRPGLSAERFVACPFGAPGERMYRTGDVVRWRADGNLEFVGRADDQVKVRGFRIELGEVEAVLAAHPLVGQAAVLVREDTPGDKRLVGYVAPEATPVHDGATGEGLAAAVRAFVQERVPDYMVPSAVVVLDELPLTVNGKLDRRALPAPDYRAAVTGRAPGTPREKALCELFAEVLGLPRVGVDDSFFDLGGHSLLATRLTSRIRSVLGVELPIRALFEAPTVAGLAGWLDAQPDAEPGGQPAEQPGTTPDAPTGARPGSPSGAGAPSGAKKKARPALRPRPRPMQEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNB0</accession>
    <name>A0A2G1XNB0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CGA synthase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blsF</name>
        <name evidence="2" type="ORF">BLA24_05535</name>
        <name evidence="3" type="ORF">CYQ11_01995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52735">
        <property type="protein sequence ID" value="PHQ52735"/>
        <property type="gene ID" value="BLA24_05535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11830">
        <property type="protein sequence ID" value="PPT11830"/>
        <property type="gene ID" value="CYQ11_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031013">
        <property type="entry name" value="CGA_synth-rel"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04469">
        <property type="entry name" value="CGA_synth_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="317" mass="32981" checksum="AA46838BC76AC1F9" modified="2018-01-31" version="1">MAVLNPGGAPSPSGRDARPAPVAVPHHRVLLVSRDDELDSLLACRRIAAHLGGLTTTRRVAGDAPPDAALVCDDRTATHRLLRRGVPVIHLHSGHRGTAAGRAPHGALPRAHRPEWLPGPWPSEDGARPTGSLAPARTARDRTRSGALLLLSLWGVPDGEAEAFVHGPLRTLVRGATADGRRCEVVCDTRLGHVRSALADTGGPGMRLSRAAEVDVDALHAAAAVFVASPTLGALVLAQARRAPLVLLPPLGAVQRDLAGRVARAAAVPVADDPGDPSLWVPPETGTPWAALDPAPDDLRGAQRVARGLRQLSLAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNC1</accession>
    <name>A0A2G1XNC1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52754">
        <property type="protein sequence ID" value="PHQ52754"/>
        <property type="gene ID" value="BLA24_05670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="990" mass="107633" checksum="5E5FFCFE419AE5A9" modified="2018-01-31" version="1">MIPAGPASHESAREGRDDTGRGRAHGATDPCHGTRPPCRRATGAQPPRATHLARTWRFTGISATPGRVGAPMQTANRSHHAHIRHSDPCPPHGRPAARRAAEAGATPHLLRCGVDPAGRVLLAVHVPAFRGRLLRDLVRARDLGGHRDRPRRVRAAQVPGGGRAPVTPAPRLRRIWVLRLVTAVVAVAAVFASLPGEALPAAHALPVAAKPKPKPPVPGDWTRIPLYDHPISQFGYELRVAARKANPYDEANLYSNAVVGFVDMTSELTEERDSGDHGQASARLSEKYGNFKIVEAADQPDLFASLGLDPKVTALMVVPRLNNPSRDANGKFNPGKRHAEMELLWTLKKKNISWERLLALWTERSPCAAGDTSCFRLLQTYAPHVKVFDSTTHKDWGDGSAKQNAEDIRKGLEAERERRAKQKSAPDPQAQATVGSAFAPHTADDCQTSGAGRLKSGPSLALTAAHSPLARSVVTADHPCGEGGSESDAKAKQPSALAKILTMPESDPGGIDFSSLNLRYMADTGSAKTGLRYSMGAAPVGSSGQNRRSDGVKALKETSDAFFVWLSLRPSAFWVNLNPNEPDRIVDSAFGRTDAGRILLQADLRMKKTVAQLIHPDTGLGSDYWSRLQGTCMSMRTWIVPGEAEVRATPDELYILDAPLKVKMETQYFQGRGAGGSAACTRQGKAAEERNESLFRSMILPKVEEAVNTAPEYADLRRVYLSRVAAEWYRDVSRRKNATYAKLIDRGDVSQWTTRSGWKPRDTFDAYVDSFKKGEFKVTRRTTEGDAIYEKTYVFGGVDLSNVPLRKVDDGRFKAEWPDAAKSAERSWDRPVPGGDGSARTLLLGGGPSPAEARRAADGGFTWSDAWDVVPLRWGVLGALIAVAVVLRRRPRPQPASPALGPQPLVVAPPTTPIDPRGLPLPLRIQGLATALCYAVGIVCTGNGVMGWMDDHRVWWARWLLLPGIALMAIGHYAGRALRRRAAARPPRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNM6</accession>
    <name>A0A2G1XNM6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05610</name>
        <name evidence="4" type="ORF">CYQ11_02070</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52820">
        <property type="protein sequence ID" value="PHQ52820"/>
        <property type="gene ID" value="BLA24_05610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16297">
        <property type="protein sequence ID" value="PPT16297"/>
        <property type="gene ID" value="CYQ11_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="21206" checksum="858D4F52024E8DC2" modified="2018-01-31" version="1">MALEHAILVSLLEKPGSGYELARRFERSIGYFWTATHQQIYRVLKRMVGDGWIDVHEVAQQGRPDKKEYSVAAPGREALSQWLHEPVEPESIRHDLAVKIRGAAFDDPAVLIREVERHHRVHSERLAHYLAGERRDFTGPGAAGTLDAGRELQHVVLRGGIAYERMTLDWLDDVLATLHRIHGPEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPE8</accession>
    <name>A0A2G1XPE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03635</name>
        <name evidence="4" type="ORF">BLA24_03640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000049">
        <property type="protein sequence ID" value="PHQ53092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000049">
        <property type="protein sequence ID" value="PHQ53093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53092">
        <property type="protein sequence ID" value="PHQ53092"/>
        <property type="gene ID" value="BLA24_03635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53093">
        <property type="protein sequence ID" value="PHQ53093"/>
        <property type="gene ID" value="BLA24_03640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="255" mass="27752" checksum="0AA29DA09D044A96" modified="2018-01-31" version="1">MQIQLPIPPREVQARIIEMLDAVDDQITALDAEADALSKVESGLRRNLFNRLVVPVVPAGEKFEMRLGRQKSARQSIGDHVHPYLRAANIGVGTLDLSDLKTMNFEPREQEKYAVHPGDVLLVEGGSIGQAALWAGEVDGFVGFDKHVIRIRAREGVSTPEYALQWCHWAREDGQFAGQATGITIKALGFSRASNMSVPDLPVAQQARLTGPLAAAAEQVVATRAEASRLRQVRAALLSGLLDRTIDIESADSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPG8</accession>
    <name>A0A2G1XPG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03335</name>
        <name evidence="3" type="ORF">CYQ11_16955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53116">
        <property type="protein sequence ID" value="PHQ53116"/>
        <property type="gene ID" value="BLA24_03335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14332">
        <property type="protein sequence ID" value="PPT14332"/>
        <property type="gene ID" value="CYQ11_16955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="303" mass="33504" checksum="F0EF3EF33720792F" modified="2018-01-31" version="1">MAKTKKAKPDKVQDDALKKQSKDPERGSGKSSGKPAKADKASKPGKGFPKGAGGAVPDEVGLDFARAWVEFPDPADDEQVFRCDLTWLTSRWTCVFGSGCQGIQAGRADDGCCTLGAHFSDEDDEKRVATHVARLTPDIWQFHEEGTRTGWTQADEDGDRQTRRWQGSCIFQNRPGFAGGAGCSLHILALKEGREPLETKPDVCWQLPVRRTYDWIDRPDDTQVLQISIGEYDRRGWGSGGHDLHWWCTSARSAHGAGEPVYVSYRAELTELMGKKGYARLVELCEERMASLLPMAPHPADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPI2</accession>
    <name>A0A2G1XPI2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02005</name>
        <name evidence="3" type="ORF">CYQ11_04365</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53142">
        <property type="protein sequence ID" value="PHQ53142"/>
        <property type="gene ID" value="BLA24_02005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12232">
        <property type="protein sequence ID" value="PPT12232"/>
        <property type="gene ID" value="CYQ11_04365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="520" mass="55963" checksum="B0ECB6B64307CBE5" modified="2018-01-31" version="1">MTSPAPAAVPPQLNGPALPGAPGSARAGGTPVAPGPAADEGLARRLRALACTAPLHDLDVRKANLAGEFGVYAMAEVALAAIDLVTLNMDFDTGADHEQIVARLLPRVAAQAPGRPQAEHERVARWVLENLINVGSVDRGFRAVYGTFGADGAYVRRDYDFKLVEEVPGPGGTVFLRTTDEAVNVLVGALDTDVTSAQIAAEVKLEVLIRRGRLADAQLAAEQARYRTVQYAETLRKTLDATRRNVRAVDWLRTVPDMIAEALDHVADRYRHENAILTNIRKARDEAEDPENKRRAAELVDIVKDCIRRHTQLQSRLLEAGPLFRAEQDRQAFSAPAARSGLDLYGQLLAPVLPLPVEQAGRVTDAFFARGTGLRTPASVRVGDLVEMLLTPPAEREHLGAEMPEPDLVETPDDSRFSEEQLASAMELLTLPPDAPRRLSGLLAEARLRDPELPYLVALLAVHAASPSVGTAYRQGERSLLFAVDDGTRLDDVEFGGADLIVGTALLDAAGMAADRAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPS6</accession>
    <name>A0A2G1XPS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02650</name>
        <name evidence="4" type="ORF">CYQ11_04945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53232">
        <property type="protein sequence ID" value="PHQ53232"/>
        <property type="gene ID" value="BLA24_02650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12324">
        <property type="protein sequence ID" value="PPT12324"/>
        <property type="gene ID" value="CYQ11_04945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="68"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="338" mass="35698" checksum="4EF1D03F830A2A6D" modified="2018-01-31" version="1">MSTGRSVTPMGPAELVQAAAMARRFYLEGKSKIQIAEEFGVSRFKVARVLETALERDLVRIEIRVPAELDAERSDALRARYGLRHAVVVESPADAADDAPDPENLGEVAADLLGELVHEGDVLGLAWGRSTIHMAAALHRLPPCTVVQLTGVYDAGTAERGSVEAVRRAAQVSGGEAHPIYAPMLLPDSATAAALRGQTGIARAFDYFDKVTVAAVSIGSWAPGISTVYDMLTEEERAHYASLGAAAEMSAHLFDAEGRRIGRDLGERCITVEADRLRRIPEVVAIAGGLRKAAAIGAVLRSGLVTSLVTDTAAADHLLLETGPGPRPALDRADPDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT6</accession>
    <name>A0A2G1XPT6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">BLA24_02680</name>
        <name evidence="18" type="ORF">CYQ11_04975</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53236">
        <property type="protein sequence ID" value="PHQ53236"/>
        <property type="gene ID" value="BLA24_02680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12329">
        <property type="protein sequence ID" value="PPT12329"/>
        <property type="gene ID" value="CYQ11_04975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="124"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="250"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ53236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT12329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="402" mass="43526" checksum="E72301CC9951E219" modified="2018-01-31" version="1">MSRRLFTSESVTEGHPDKIADQISDAILDALLKEDPTSRVAVETLITTGLVHVAGEVTTKAYAPIASLVRNKILEIGYDSSKKGFDGASCGVSVSIGAQSPDIAQGVDTAYENRVEGDEDELDKQGAGDQGLMFGYACDETPELMPLPIHLAHRLSRRLSEVRKNGTIPYLRPDGKTQVTIEYDGNKAVRLDTVVVSSQHASDIDLDSLLAPDIREFVVEHVLKELVEDGIKLDTEGYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAARCEVQVAYAIGKAEPVGLFVETFGTNTVDTDKIEHAIGEVFDLRPAAIIRDLDLLRPIYSQTAAYGHFGRELPDFTWERTDRVEALRKAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT8</accession>
    <name>A0A2G1XPT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_02640</name>
        <name evidence="10" type="ORF">CYQ11_04935</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53230">
        <property type="protein sequence ID" value="PHQ53230"/>
        <property type="gene ID" value="BLA24_02640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12322">
        <property type="protein sequence ID" value="PPT12322"/>
        <property type="gene ID" value="CYQ11_04935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="116"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="381" mass="39634" checksum="1C73714158DD9CE2" modified="2018-01-31" version="1">MPEPLPDPLAAARLLVGELVAGRPAEWDLKGELPRELLTALGARGALCAQVPARFGGLAATSRANGEFTAYVGSLCSSLRSVMTSQGMAAWAVQRLGTREQRDTHLPRLTGGELAAVAFSEPAAGSDLSAMTTRLRVDGDTVVLDGQKKWITAAHYADLLVVFARYDDGSGEDAAAAVVVPASAPGVRVRRVADPLGCRAAGHADLTFDAVRLPASAVLGGCGQSLQLLVTAALTYGRFSVAWGCVGILRACLDAATRHASAREQFGKPLARHQLVAGHLADLFVAEQSATRASEHASDRWDSGSSDVAMAAVLAKHTAAELAAHGAARAVQVLGSAGAVDGEVVARAYRDAKLMEIIEGSNEICRLLLAQHAVTAANRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPZ8</accession>
    <name>A0A2G1XPZ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4365 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02975</name>
        <name evidence="3" type="ORF">CYQ11_05275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53290">
        <property type="protein sequence ID" value="PHQ53290"/>
        <property type="gene ID" value="BLA24_02975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12387">
        <property type="protein sequence ID" value="PPT12387"/>
        <property type="gene ID" value="CYQ11_05275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025375">
        <property type="entry name" value="DUF4365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14280">
        <property type="entry name" value="DUF4365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4365" evidence="1">
        <location>
            <begin position="38"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20985" checksum="E74D6B5319C5568E" modified="2018-01-31" version="1">MALAQPDPAAPPDHRAPGPLAALRGALATTACMETLQIGYLHAVAAAAGCSLAQPFPDNGIDWHLSHSAPGHTTDDEVTIKVQLKCTYQLGPRHPADATFGFTLDNDHLAKLARTPVSVHKILVVMIVPRAREDWLRAGHDRLELRHCCYWTNLAGHPVTGRRRTTVRIPTSRVFDDRALCEIMTRVGAGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQL1</accession>
    <name>A0A2G1XQL1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00685</name>
        <name evidence="6" type="ORF">CYQ11_07695</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53481">
        <property type="protein sequence ID" value="PHQ53481"/>
        <property type="gene ID" value="BLA24_00685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12786">
        <property type="protein sequence ID" value="PPT12786"/>
        <property type="gene ID" value="CYQ11_07695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="93"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="313" mass="33801" checksum="F4EE5BD51073C31A" modified="2018-01-31" version="1">MSTIPEIRALPVPDGLEGERVDAAIARMFGFSRTKAAELAAAGKVQLDGAEAGKSDRVTGGAWLEVELPAPPAPVQIVAEPVEGMEIVHDDDDIVVIVKPVGVAAHPSPGWTGPTVIGGLAAAGYRISTSGAAERQGIVHRLDVGTSGLMVVAKSERAYTLLKQQFRERTVDKRYHSLVQGHPDPMSGTIDAPIGRHPNHDYKWAVTAEGKPSVTHYDLIEAFRAASLLDIKLETGRTHQIRVHMAAHRHPCVGDLTYGADPTIAKRLGLTRQWLHAVRLGFEHPGDGRWVEFESAYPDDLQHALDTVRAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQN4</accession>
    <name>A0A2G1XQN4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00565</name>
        <name evidence="6" type="ORF">CYQ11_07575</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53459">
        <property type="protein sequence ID" value="PHQ53459"/>
        <property type="gene ID" value="BLA24_00565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12764">
        <property type="protein sequence ID" value="PPT12764"/>
        <property type="gene ID" value="CYQ11_07575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304780" evidence="2">
        <location>
            <begin position="35"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="4">
        <location>
            <begin position="54"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="3">
        <location>
            <begin position="163"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="556" mass="59802" checksum="9CE2EDA2FB74E6BD" modified="2018-01-31" version="1">MTSHDISRRTAVTAAAATATAALLPLAAPTTAHADSVPSGAGSPATGQGTAFLHGVASGDPLPDGVLLWTRVTPSPDAVPGSGLGAAVEVGWEVAEDAAFARVTARGKVTATAAADHTVKADVRGLRPATEYFFRFSAGEAASPVGRTRTAPAHGEATAGVRFGVVSCANWESGWFSTYRHLAARRDLDAVLHLGDYIYEYKSGEYPAATYVVRPHAPQHEITTLADYRTRHGHYKTDADLQALHHAHPVIAIWDDHEFANDAWAGGAENHTPGEEGDWSARMAAAKQAYFEWMPVRPSVEGTTYRRLRFGKLADLHLLDLRSFRSQQVKPGSGKVDDPERTITGRAQLDWLKDGLAGSDTTWRFVGTSVMISPVAFGSLPAHLLEPLAKLLGLPAGGIAVNTDQWDGYTDDRRELIGHLVDRGIRNTVFLTGDIHMAWANDVPKQAATYPLSPSVATEFVVTSVTADNLDDILHVAPHTVSLAAVAALKAANRHAKWIDMDSHGYGVLDVTAERAQMDYYVLSDKRDAKATASWARSYRTLSGTQKVERVDAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQS3</accession>
    <name>A0A2G1XQS3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000002">
        <property type="protein sequence ID" value="PHQ53595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53595">
        <property type="protein sequence ID" value="PHQ53595"/>
        <property type="gene ID" value="BLA24_00030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="63" mass="6955" checksum="6D7759B058D43F3E" modified="2018-01-31" version="1">MEGADEAVSPILELAPENRINGIINSAMRVHKALSRSPLAPSGSELQERIEMFTRTPLRSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQW0</accession>
    <name>A0A2G1XQW0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01055</name>
        <name evidence="4" type="ORF">CYQ11_08065</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53549">
        <property type="protein sequence ID" value="PHQ53549"/>
        <property type="gene ID" value="BLA24_01055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12854">
        <property type="protein sequence ID" value="PPT12854"/>
        <property type="gene ID" value="CYQ11_08065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="135" mass="14653" checksum="48C9CA6EEA07D903" modified="2018-01-31" version="1">MRPTATVLVYSDDASTREQVRLAGGRRPAADVPPVEYLECATLPAVLRTLEEHRVDVCVLDGETAPAGGMGVCRQLKDEVFRCPPVLLLIGRPQDAWLATWSRADAAVTHPLDPVAFAESLAELLRPGDRQPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9J5</accession>
    <name>A0A2G1X9J5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30825</name>
        <name evidence="3" type="ORF">CYQ11_23925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47900">
        <property type="protein sequence ID" value="PHQ47900"/>
        <property type="gene ID" value="BLA24_30825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15525">
        <property type="protein sequence ID" value="PPT15525"/>
        <property type="gene ID" value="CYQ11_23925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304795" evidence="1">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="143" mass="16184" checksum="9B86694B5962AF50" modified="2018-01-31" version="1">MVFMRINRLAKTAAAGAAAVTLVTAFQVPAHANDKDGRCEYGEVCLYENRSWQGGLFDDNGWLQDYAGYTFSRTGDPIDNNVASVINNNGSMYWRGWQYRGNSGWHFDVNKRGQCGEGCDHFDRWSELPPGIKNALSSHEWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9N4</accession>
    <name>A0A2G1X9N4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_31230</name>
        <name evidence="9" type="ORF">CYQ11_24270</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47940">
        <property type="protein sequence ID" value="PHQ47940"/>
        <property type="gene ID" value="BLA24_31230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15564">
        <property type="protein sequence ID" value="PPT15564"/>
        <property type="gene ID" value="CYQ11_24270"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ47940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1550" mass="169330" checksum="774EB4B25533287B" modified="2018-01-31" version="1">MGHAGMPKTGGLSAAMNNLFERTRRKEQPTGIVPVGRDRTLKASFAQQRLWFLDQLEPGNASYNIPLAMRIHGDLDTGCLARAVSEVVGRHEALRTTFGEDGGEPVQLIRPAGPVPVPVVDVPGASPDERLAAAREMAGAEIAEPFDLAVGPLLRGKILRLDDQDHVLLLNVHHVATDAWSQGVLVRELSAVYGALVAGRSPALPPLPVQYADYAVWEREWLSGPTLRRQLDYWKKQLAGMEPALELPTDRPRPSVARQEGEAARWELPAELVDTARKLGAGENATLYMTLLAAFKLVLARYVDSEDIVVGTPVANRGRSEIEGLIGFFVNTVVLRTDLSGDPTYRELLRRVRDTTVGAFAHGDLPFEYLVEHVQPERDLSRNPLVQVLFQMINIPAERLSLAGLATEQFDPGRILTRMDLEFHLVEGDDGGLIGHIVYSKALFDAPTIERLLHHIGVVLRAALADPDRPVSELSLLDEAERTLVVEGFNDTAQPLPEGSLSDLFSAQARLRPDAVAVVHGDDRLTYAELERRANQLAHHLQDRGVGDEDLVGLCVERGADVIVAILGILRAGAAYVPIDPNHPRDRIRFVLDDAKVATAVTQQRFTGLFEAPGTDLVLLDAEREDLAARPGTPPATPTRADALAYVIYTSGSTGVPKGILMPGSCIINLVAWQKRALPIGPDARTAQFATVTFDISLQEIFSALLYGETIVVPDEELRMDPAAFARWAHEQELAQLFVPNVMLRAISEEVDPHGPELSALRHLSQAGEPLSLHHDLRELCENRPELRLHNHYGPSEAHVVTSYSLPADVADWPLTAPIGKPIGNTRVYVVDRDLRPVPVGVPGELCVAGAGLARGYLGRPELTASRFVEDPFRDDGSRMYRSGDLVRWLSDGNLEFLGRIDDQVKIRGFRIEPGEIEAILARHADVLHAAVIVREDVPGDKRLVAYAVAEPGAADRDGRLAETLRQHVESAVPEYMVPSAVVLLESMPLTTGGKIDRGALPAPDLRTVLEVGYVAPRTPEEEAICGIYADLLGSERVGIEDDFFSLGGHSLIATRVVARIRAALGVAIPLKTIFQQRTPRELAVTVASAPRADAGPGLPPLVPAERDRSLPVPFSFAQRQADLFFEDVRRAGHWNIPLAVRVSGELDLAHLRRAMEVLVARHEALRITVVGEPGAYVQAVQASAPVRVEVTNVADAAEAADLAGLEAVRPFDLTGDALARLSVLRLGERDHVLVLSLHHLVTDGWSRGVLIRDLSEVYSALVAGGEPDLPAVPVQYTDFTLWERQWLRGPLLEEQLDFWNRHYDGMVPAQLPTDRPRAAVADYDSGLFHWQLPQDVVTSARKLGESANATLYMTLLAAMKLVVSARSASPDVLVGMPMANRGHDELENMVGLVSKMLAVRTDLGGDPTFHELLVKVRDAMSDAHTHQDVPFVSAIERWADGARLFEDPAVKVVFQIVNTPPQELRLAEATAEPFVMSHPPVRFNLDMEIDLYEDAVDGALAGTVLYSTSLFDDATIESLCEDVMAVVTAAAADPGRTLSQVWDERFDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Q4</accession>
    <name>A0A2G1X9Q4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31345</name>
        <name evidence="4" type="ORF">CYQ11_24385</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47960">
        <property type="protein sequence ID" value="PHQ47960"/>
        <property type="gene ID" value="BLA24_31345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15584">
        <property type="protein sequence ID" value="PPT15584"/>
        <property type="gene ID" value="CYQ11_24385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="509" mass="56128" checksum="C7B81CA2336325FA" modified="2018-01-31" version="1">MTDAYLGRIGKLIRDARQHRGWTQTQLADALGTSQSAVNRIERGNQNISLDMIARIGEALDSEIVSLGYAGPMHLRVVGGRRLSGSIDVKTSKNACVALLCATLLNAGRTTLRRVARIEEVYRILEVLASIGVRHRWINDGNDLEIVPPAELDLAAMDTEAARRTRSVIMFLGPLLHRMDHFKIPYAGGCDLGTRTVQPHMTALRHFGLEITATDGTYHAQVDRSVAPTRAIVLTERGDTVTENALLAAARHDGVTVIRNASSNYMVQDLCFFLEELGVRVEGVGTTTLTVHGVATIDRDVDYAPSEDPVEAMSLLAAAVVTESELTIRRVPVEFMEIELAVLEEMGLDHERSAEYRADNGRTRLLDLTVRPSKLCAPIDKIHPMPFPGLNIDNVPFFAAIAAFAQGQTLIHDWVYDNRAIYLTDLNRLGADVKLLDPHRVLVEGPTRWRSAEMMCPPALRPAVVVLLAMMAAEGTSVLRNVYVINRGYEDLAERLNSIGAQIETFRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9S4</accession>
    <name>A0A2G1X9S4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31445</name>
        <name evidence="4" type="ORF">CYQ11_24490</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47976">
        <property type="protein sequence ID" value="PHQ47976"/>
        <property type="gene ID" value="BLA24_31445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15601">
        <property type="protein sequence ID" value="PPT15601"/>
        <property type="gene ID" value="CYQ11_24490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005506">
        <property type="entry name" value="DUF312"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03752">
        <property type="entry name" value="ALF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1212" mass="126364" checksum="8816ED47812D917C" modified="2018-01-31" version="1">MWLSVDWTDQKETARMRRPLRPRIGARLKPESLRGGRKHLFSLRGTVSGALPVALLACLLGGSPAAAAEDQNWSPERGLVVELWKTGGAGVKEAAEQALLGTDEDVKKFFDVVDSLQYDDDSVDASRVFSVGGPAVREAAKKALKGTPEELRAFLRDGWKAPLADDQIVEASRVASFGGPGVKEAGQAALKGTPADVARFLEVGQYEERETDNQVLVGQIISAGGPNVQAAGKLAFNGTPEDIVEFLEVGQFTARSRDQEHATIAELTEQAEKAGLQAQQATEASQKASARAVAASEQAKAAAQKAARETKAAKDDSKKAAVKAQQAAEAARGAAAAAQQAIGAANAAQRSARVAALAAAQTASAANAAAEAATRAYNAAIAAGGDASKAAEARDYAKQARAAAGLAKKSAEAADQAGKASWAAGEAVKASKSARDNAMDAANAADEANQYADAAGVHSNAAAVAAAETRQHAQEANRAANAAEALAGRSANAAYEARDAANSAAYHANKAADAAEEAAKHAGESKDAATESAKQAGAAKEAADAASKAVATAKKVFAIARDTEAEELATRMAAAIERAKSDQRQAEKFTSAAAAQEVEARGLDDTAKALAAEAAKSDVDVKAVAAKGRALALKAMKLRGPFQQEAAARALSGTDADVVGYLRGGWEKAGQEEIRQQVVDLSVQSPFEAVRSAAQAALKGSDQQIKDFYTTGQYAAGDVDYDVRVSQIYSAGGPGVKEAAKAALASRDTKKLVAFLNVGQHQARNDDEQVLAAQIFSAGGPEVKAAARIAMAGPADQLHAFIQTGQYTADRKDQLSATHIARLQNLIDHGSQIAAKAQENSWIAAKAAAVAKGASTDADKAADQAKKSADEAKGYAADADRSARQAESSAAKAAKSATTARNAADAADRDADAATESAAQAEFSAIYARQSASDAADYADDARSSAVAAGKNAEEANTYASKAWEEVLKKRQAEQAEAQRLAEQQRKQIEKERREKEKRKCRAIPDHPGNELGGMACTRGPGAWTIDDTPPDPRLTKAVWVVTGLQDIEDCAKNPTLDKCAVAAMVALPFGRLKAAEKLAEGVKGAARGSRVARAAATGGFKVALTPEEIAAINRSVGGKILYTGSPENMYINASRYNSFWDKIAVVVRDIAGAHMYNDGNKRTAEAVAEQLIERNRIRVRPTPEALEKIVLRVGKGELREINEISAALKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Y6</accession>
    <name>A0A2G1X9Y6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31890</name>
        <name evidence="2" type="ORF">CYQ11_24945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48054">
        <property type="protein sequence ID" value="PHQ48054"/>
        <property type="gene ID" value="BLA24_31890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15680">
        <property type="protein sequence ID" value="PPT15680"/>
        <property type="gene ID" value="CYQ11_24945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045682">
        <property type="entry name" value="DUF6193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19692">
        <property type="entry name" value="DUF6193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="129" mass="14186" checksum="B6593082ED39DF6D" modified="2018-01-31" version="1">MSDNNSTHEAVEIVAAAWQRVLAMDENLVDPKKTRLTYSYPELRVLYPLVSHGMLQLSRCTDFPWTADVPVIYRRVEGGYVVRRLDRPNGADDAIVGYTDTLEDAVALVAANLPPGCGPAIQGTPDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA33</accession>
    <name>A0A2G1XA33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1453 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32000</name>
        <name evidence="3" type="ORF">CYQ11_25055</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48071">
        <property type="protein sequence ID" value="PHQ48071"/>
        <property type="gene ID" value="BLA24_32000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15697">
        <property type="protein sequence ID" value="PPT15697"/>
        <property type="gene ID" value="CYQ11_25055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="16434" checksum="457F083617E13B3C" modified="2018-01-31" version="1">MNVWLLAGLIAVAAVAVIAKRLGGEPLNVRDLFAPAVVLTALGGWSVYRAHDLTGGDLAWAVAGVALGLALGALRGRTVHVFEKQGVLWQRYTGRTFLVIALSVPVMGGFALLAASMGMHEQARPVQLSIGVGFLGEALVIGRRGLVSGIPFAPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA71</accession>
    <name>A0A2G1XA71_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32355</name>
        <name evidence="3" type="ORF">CYQ11_25405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48126">
        <property type="protein sequence ID" value="PHQ48126"/>
        <property type="gene ID" value="BLA24_32355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15752">
        <property type="protein sequence ID" value="PPT15752"/>
        <property type="gene ID" value="CYQ11_25405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="104"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="30622" checksum="D5CCE4B69F12D73C" modified="2018-01-31" version="1">MGIVERLVPDELWELFQRVVPEAPTRPQGGGRRRHGDREVLAAILFVATSGCTWQQLPSASFGPSGATAHRRFTEWSKARVWAKLHRLVLDELGARGELDWSRCAIDSVNMRALKKGDLTGPNPVDRGKYGSEIHLITERTGLPLSVGISGANLHDSQALIPLVKGIPPIRSRRGRRRRRPGKLHGDKGYDYDHLRRWLRGRGIRHRIARKGIESSSRLGRHRWTVERTMSWLAGCRRLHRRYERKAEHFLAFTSIACILICYRRLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA94</accession>
    <name>A0A2G1XA94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_32535</name>
        <name evidence="7" type="ORF">CYQ11_25585</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48154">
        <property type="protein sequence ID" value="PHQ48154"/>
        <property type="gene ID" value="BLA24_32535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15780">
        <property type="protein sequence ID" value="PPT15780"/>
        <property type="gene ID" value="CYQ11_25585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="327" mass="35459" checksum="8E4DD2153C7460F0" modified="2018-01-31" version="1">MTGTVEGLSPVNRLRPRRSCLAVPGSNPRFLEKAQGLPADQVFLDLEDACAPLAKEGARHTIVDALNNGDWTGKTRVVRVNDWTTHWTYRDVITVVEGAGPNLDCIMLPKVQDAQQVVALDLLLTQIEKTMGFEVGRIGIEAQIENARGLVNVDAIAAASPRLETIIFGPADFMASINMKSLVVGEQPPGYPADAYHYILMRILMAARAHDLQAIDGPYLQIKNVEGYKEVAGRAAALGFDGKWVLHPGQVEAANEVFSPSQEDYDHAELILDAYDWCTSEAGGKKGSAMLGDEMIDEASRKMALVIAGKGRAAGMTRTSKFEIPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAL4</accession>
    <name>A0A2G1XAL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33100</name>
        <name evidence="3" type="ORF">CYQ11_26150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48251">
        <property type="protein sequence ID" value="PHQ48251"/>
        <property type="gene ID" value="BLA24_33100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15881">
        <property type="protein sequence ID" value="PPT15881"/>
        <property type="gene ID" value="CYQ11_26150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="28986" checksum="0DF11C69BEA67403" modified="2018-01-31" version="1">MADDSNSFSKGAIGSYAAVGDSFTEGVGDPGPDGTFIGWADRLAVLLSDQRDEHSFRYANLAVRGRLLDQIVEEQVPRAKELAPDLVTFCAGGNDILRPGSDPDDVAQRYEAAVVRLSESVGTVLLCTGFDTRGVPVLRHLRGKIATYTAHVRAIADRHDCPVLDLWSLRSVQDRRAWSEDRLHLSADGHTRVALRAAQVLGLEVPADPDQAWPDEEQRSAAEVRRDNINWAREHLVPWIGRRLRGQSSGDNVEPKRPDLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAM0</accession>
    <name>A0A2G1XAM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33260</name>
        <name evidence="3" type="ORF">CYQ11_26310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48276">
        <property type="protein sequence ID" value="PHQ48276"/>
        <property type="gene ID" value="BLA24_33260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15906">
        <property type="protein sequence ID" value="PPT15906"/>
        <property type="gene ID" value="CYQ11_26310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045361">
        <property type="entry name" value="CIS_tube_prot_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19266">
        <property type="entry name" value="CIS_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="181"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="25379" checksum="3297C70BCAE48FA0" modified="2018-01-31" version="1">MLSELLGGAPVRAALVIYDPPTGTGNAPGPERGRVRFHFNPDRVQIGKRARWDRSPAPSSEEAPRAQFVGAQPRTLTLEVFLDAGDFRSSVQDQVEKLLDCCAPTARSATAKPASAPWVRLEWGRSHTTAFLALVTQVDAAYTRFGHDGTPLRATCTVSLEEVGGATPRQNPTSGADGPVDTHLVVGGDTLAGLAWQAYGDPTRWRAIAEANGVDDPARVPVGTVLVLPVLEERPAGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAN5</accession>
    <name>A0A2G1XAN5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33235</name>
        <name evidence="3" type="ORF">CYQ11_26285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48272">
        <property type="protein sequence ID" value="PHQ48272"/>
        <property type="gene ID" value="BLA24_33235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15902">
        <property type="protein sequence ID" value="PPT15902"/>
        <property type="gene ID" value="CYQ11_26285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="445"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1097" mass="115064" checksum="F5512A812AF1FC4B" modified="2018-01-31" version="1">MSLPTPEYDRRTRDEVVAGAVAAVRRKVGAWTGQDRTDPGRGLIETCADMVMGLRDRLNLAPDQRRLQVLRLLGVRPYQPAPAQTEVVLQLAAPSPEPVVVPAGQEVATRPVGEAEPVVFSTLTEAVLNPCVLVAAGDFAESGRADGAVEGTLTAFGPGAGRTVEPGGPAFAGPAFHLNLPYFGDFPPPGDALADTGRVSTDSGGPSLSSYALVVLSVPVPSTRVTLDVTMGAGPTPEVGTGVTRGHWEAWQGTHWTGCRVVTDTVAVQGRPGKVTLDLPPAHAPAQLLLHRAVGEGGDSVQRLRDVGLIRYRADADRSALTRVALDPVLAVSVPVVQAGLVRNETLGTAAGTPGERLRFAHPPLPRSTDPLVVEAVLGERTAQWTYVASLAGSGPGDRHFTLDPRTGEAVFAPVVAGARGPRQHGAPLPAGAVVRIRRYLTGGGARGNVPARTITVLRTPLPYVSAVTNPAPAVGGTERESAAACATRLPLGAPVPERAVVPADYEQLALAASAGMARIHHVGDAPDDALDPARNYLPWRPAKTDVVFTLAPGALTVLKGIQVIAPTEDGETVFTTTEEATRVPPDAVGAAHLGLVPGVTAAVGMFAAGDYQAGGEFSGPFKEGGGLVLALVEIKKPHNPGHLTLWVTAGGNRGPEDRIAVSVFAPRKTAPWWDTAAPLAYASAPAQEITVADGPTVSAHPVYVSKSERWQAAVARGDLARTAQDAVDGRGAGFPTEEAVCWIAVQILDPKGTPTTTYTVYADSGTTDPVPAEQYEEHDRAREPFLSTGEPGQVHPLLHSPVYGQLPKVRVGTENWHSVTSFHESLEDSKDVVINASTGQVHFGPKVTGGSSEPRQYGAVPLPEGTPITVDGLYKATLGAAGNGIPPGGISRLRNPDDDHIVGVRNVTTSHDGKNGYTDTSGGSTQAGVTLMVIPFVTADERGWFPFHMLTPTRDASDTLRRSLRACQPEGVPVWLKQPVYHGIRVDARIVPADYRTAEERAELRAAAERALYRYFSPVGGGPDGTGWPLGRPVYAGEAFRVLEQVPGVGRVATAELVPVDLLDGSASDPVLRIHCGPGETVYSVEHRVTVAEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAQ9</accession>
    <name>A0A2G1XAQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_30520</name>
        <name evidence="9" type="ORF">CYQ11_23615</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48327">
        <property type="protein sequence ID" value="PHQ48327"/>
        <property type="gene ID" value="BLA24_30520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16751">
        <property type="protein sequence ID" value="PPT16751"/>
        <property type="gene ID" value="CYQ11_23615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="531" mass="54386" checksum="4D7DFDCE6B59A6E2" modified="2018-01-31" version="1">MNGDHQGLALTLFSVFVVVALAISTWFGRERQGTPEEFYAGGRLFSPMENGFAIAGDYMSAASFLGISGLIALYGYDGMLYSVGFLVAWLVVLFLVAELVRNCGRFTLADVLAARLRERPVRIAAGASSVVVSVLYLVAQMVGAGSLVALLLGGTDGRARGWTVVAVGALMVVYVTVGGMRATTWIQIVKAVLLMGGTATLTVLVLVRFHGDVSALLGTAADRSGHGRAFLAPGLRYGHDLTSRLDFISLGLALVLGTAGLPHILSRFSTVPTARAARRSVVWSIGLIGGFYLMTIVLGFGAAAVLGSDAVRASSAAGNTAVPLLALDLGGGAGSTGGTILFAVVAAIAFATILAVVAGVTLASSASVAHDLYGTLRRRGGRAPRDEVTVARAAAAGTGVVAIGLGLLAQNLNVAFLVGLAFAVAASANLPVLLYSLFWHRFTTRGAVWSVYGGLVPAVVLVLFSPVVSGAPDAVFPGLDFRLFPLENPGLVSVPLGFLAGWAGTVTSRQGADAAAHAESEVRSLTGAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAR6</accession>
    <name>A0A2G1XAR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_33215</name>
        <name evidence="2" type="ORF">CYQ11_26265</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48269">
        <property type="protein sequence ID" value="PHQ48269"/>
        <property type="gene ID" value="BLA24_33215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15899">
        <property type="protein sequence ID" value="PPT15899"/>
        <property type="gene ID" value="CYQ11_26265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045362">
        <property type="entry name" value="CIS_spike_tip"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19267">
        <property type="entry name" value="CIS_spike_tip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="10005" checksum="F25342E5D071D60E" modified="2018-01-31" version="1">MPGDIESWVIPPVGYSTPAFPIAGALRVELKVPSANRATYARTGQGETEAVVDGGPFDVVFTVDIAASNPSGSADTPGATYQGKASLTCPRVRPVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAV4</accession>
    <name>A0A2G1XAV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside deaminase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31960</name>
        <name evidence="4" type="ORF">CYQ11_25015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48353">
        <property type="protein sequence ID" value="PHQ48353"/>
        <property type="gene ID" value="BLA24_31960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16779">
        <property type="protein sequence ID" value="PPT16779"/>
        <property type="gene ID" value="CYQ11_25015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="21137" checksum="E3DDB1E9B06CCE90" modified="2018-01-31" version="1">MEHKELITEAVRLATESVEKGWGGPFGAVIVRDGEIIARGQNRVLLTGDPTAHAEVETIRKAVAHLNPEAPSISEEHQNESTLAYVPRPEGSPDPVPERARMLQGCSIYISGAPCPMCMSAIYWARIDEVYFSCDLDDTRRIGFDDAYQYEDFTKPLSERRIKIEQLHPEIGAHAYDAWTSKPDRHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAY6</accession>
    <name>A0A2G1XAY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_30065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000165">
        <property type="protein sequence ID" value="PHQ48407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48407">
        <property type="protein sequence ID" value="PHQ48407"/>
        <property type="gene ID" value="BLA24_30065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ48407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="109" mass="11327" checksum="11EC3CE1133D67E7" modified="2018-01-31" version="1">MSEAPQGAGEAARSPAGHLVPKHRMLALTDGVTAIAMTLLVLDIELPSGLRGAELDRALGEVPSQVGTFLLSALVIALFWRAHTPHWRARSGSTSGSSGSTSPSSPWCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAZ6</accession>
    <name>A0A2G1XAZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28975</name>
        <name evidence="3" type="ORF">CYQ11_06500</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48417">
        <property type="protein sequence ID" value="PHQ48417"/>
        <property type="gene ID" value="BLA24_28975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12587">
        <property type="protein sequence ID" value="PPT12587"/>
        <property type="gene ID" value="CYQ11_06500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="81" mass="8544" checksum="9F1A081EA9C0997C" modified="2018-01-31" version="1">MTDPMAPEPGEPAAPRPLGVDRTPTGHAAVDAGLARLEDADHLAVSGHLEVYEDVHQGLREALSALDQRPGPTGPTRPYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB80</accession>
    <name>A0A2G1XB80_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_29125</name>
        <name evidence="10" type="ORF">CYQ11_06350</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48439">
        <property type="protein sequence ID" value="PHQ48439"/>
        <property type="gene ID" value="BLA24_29125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12565">
        <property type="protein sequence ID" value="PPT12565"/>
        <property type="gene ID" value="CYQ11_06350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="240"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="393" mass="42660" checksum="6020D61D3D137954" modified="2018-01-31" version="1">MPEATVFDPHDPLGIDDLLTDEDRAIRDAVRQWAADRVLPHIAGWYERGEAPVRELARELGAMGALGMQLTGYGCAGATAVQYGLACLEVEAADSGIRSLVSVQGSLAMYAIHRFGSEEQKERWLPGMATGETIGCFGLTEPDHGSDPAGMRTHARRDAGGDWVLTGRKMWITNGSVAGVAIVWARTEEGIRGFVVPTDSPGFSAPDIHHKWSLRASVTSELVMDEVRLPADAVLPEAVGLRGPLGCLNHARYGIVWGAMGAARTCFETALEYARTREQFGRPIGGFQLTQAKLADMAVELHKGILLAHHLGRRMDAGRLRPEQVSFGKLNNVREAIEICRTARTVLGANGISLEYPVMRHATNLESVLTYEGTVEMHQLVLGKALTGLEAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBA3</accession>
    <name>A0A2G1XBA3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome accessory factor PafA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29665</name>
        <name evidence="4" type="ORF">CYQ11_05810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48524">
        <property type="protein sequence ID" value="PHQ48524"/>
        <property type="gene ID" value="BLA24_29665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12477">
        <property type="protein sequence ID" value="PPT12477"/>
        <property type="gene ID" value="CYQ11_05810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="497" mass="56068" checksum="DF6782F8ED846046" modified="2018-01-31" version="1">MGIETEYGISVPGHPNANAMLTSSQIVNAYAAAMHRARRARWDFEEENPLRDARGFDLAREAADSSQLTDEDIGLANVILTNGARLYVDHAHPEYSSPEITNPRDAVLWDKAGERIMAEAAERAAQLPGAQPIHLYKNNTDNKGASYGTHENYLMKRETPFSDIVRHLTPFFVSRQVVTGAGRVGIGQDGHEHGFQISQRADYFEVEVGLETTLKRPIINTRDEPHADAEKYRRLHVIIGDANLSEISTYLKLGTTALVLSMIEDGFITTDLAVEQPVRTLHQVSHDPTLRRLVTLRSGRTLTAVQLQMEYCELARKYVEDRFGADADEQTKDVLSRWDDVLGRLERDPMSLAGELDWVAKRELLEGYRRRDALDWDAARLHLVDLQYADVRPDKGLYNRLAARGKMRRLLDETDVARARTAPPEDTRAYFRGRCLEQYADDVAAASWDSVIFDLPGRDSLQRVPTLEPLRGTRNHVKELLDRCRTAEDLVRVLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBN2</accession>
    <name>A0A2G1XBN2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28230</name>
        <name evidence="4" type="ORF">CYQ11_07240</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48611">
        <property type="protein sequence ID" value="PHQ48611"/>
        <property type="gene ID" value="BLA24_28230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12708">
        <property type="protein sequence ID" value="PPT12708"/>
        <property type="gene ID" value="CYQ11_07240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="126"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="55111" checksum="70E14D06C674D878" modified="2018-01-31" version="1">MTSSTETTATTPQVAVNDIGNEEAFLAAIDETIKYFNDGDIVDGVIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPNEVVKVGDEIEALVLQKEDKEGRLILSKKRAQYERAWGTIEKIKEEDGIVTGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGKELEAKIIELDKNRNNVVLSRRAWLEQTQSEVRQTFLTTLQKGQVRSGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQEVTVEVLDVDMDRERVSLSLKATQEDPWQQFARTHQIGQVVPGKVTKLVPFGAFVRVDEGIEGLVHISELAERHVEIPEQVVQVNDEIFVKVIDIDLERRRISLSLKQANESFGADPSVVEFDPTLYGMAASYDDQGNYIYPEGFDPEANDWLPGYEKQREEWERQYAEAQQRFEQHQAQVIKSREADAEAAAEGAQAAPQAGGQVSGGSYSSESADTSGALASDEALAALREKLAGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBV4</accession>
    <name>A0A2G1XBV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline shock response membrane anchor protein AmaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28680</name>
        <name evidence="3" type="ORF">CYQ11_06785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48685">
        <property type="protein sequence ID" value="PHQ48685"/>
        <property type="gene ID" value="BLA24_28680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12634">
        <property type="protein sequence ID" value="PPT12634"/>
        <property type="gene ID" value="CYQ11_06785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="21177" checksum="D7B1D58ACFD0A45E" modified="2018-01-31" version="1">MLRNVNRVLVALAGVLLVALGAAVLIGSFGLQRRWGLALPSAWPFDGAHDVLLTLAEQRRWRGRGWWWPVVIAALAAVTLLALAWLLVQARRRRLRHLVVDSGDGDVVVVRGRALEDVLAAEAGALDGVDHAAVTLGGRRTAPEARIVLTLAPHAAPAAALHRLLAEVLQQARTSAGLARLPAEVHLRAVRHGAERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB1</accession>
    <name>A0A2G1XCB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_27700</name>
        <name evidence="9" type="ORF">CYQ11_17940</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48850">
        <property type="protein sequence ID" value="PHQ48850"/>
        <property type="gene ID" value="BLA24_27700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14503">
        <property type="protein sequence ID" value="PPT14503"/>
        <property type="gene ID" value="CYQ11_17940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="37078" checksum="070BF900FBD76EBB" modified="2018-01-31" version="1">MSATSPTAAPGKPAARAHAGARPVGYALVRAGRASFLVHRRGAAAAVGLTVLLAAACLTYLCVGTSLTPPGEALKVLFGLPSAEELTVGTFRLPRMTVGLLAGAAFGVAGALVQTLARNPLASPDVIGVSQGASAATVGAMTFGVTSYAVMPYVSVAGGLLAALLGWAFAWRGGLKAARFVLIGIGFAVALRSVTQLFLTKGDYLVAQQAKVWMTGSLNGRGWAEAVPLAWVLLALLPGVCWAARAQRTVATDDDTATALGVRLGRVRLGLALLGVVLASVATGAAGPVDFVALLAPQIARRLTRTAQIPLLCSALTGALVVVVADLLGRKLFEPTELPVGVLTAAVGAPYLIWLIMRGRTGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCH5</accession>
    <name>A0A2G1XCH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48918">
        <property type="protein sequence ID" value="PHQ48918"/>
        <property type="gene ID" value="BLA24_28080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="140" mass="15498" checksum="B4065CD80089BE8C" modified="2018-01-31" version="1">MYVQVIHEDWVDRQQAACRIMARPQMEFVVAWGGPALGVAAVILCVLLARRTRRRHGVRLGETWPGLIAYLSVGAMRWPFCWSCSCCTPRSRLTGRARFWATADSSPAGTGDATMRERSGPRRTFLTDNGGRSTEVASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCK4</accession>
    <name>A0A2G1XCK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22840</name>
        <name evidence="2" type="ORF">CYQ11_23235</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48948">
        <property type="protein sequence ID" value="PHQ48948"/>
        <property type="gene ID" value="BLA24_22840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15407">
        <property type="protein sequence ID" value="PPT15407"/>
        <property type="gene ID" value="CYQ11_23235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="74" mass="7909" checksum="A9A7248415A75559" modified="2018-01-31" version="1">MDGVSTYLALTFGTLLSSQGTDASFVLTLSGFPPGASLRCFQPYQIRFPFRFRSGIRFPVPVGGGFPTLSDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCN0</accession>
    <name>A0A2G1XCN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23105</name>
        <name evidence="4" type="ORF">CYQ11_22970</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48996">
        <property type="protein sequence ID" value="PHQ48996"/>
        <property type="gene ID" value="BLA24_23105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15359">
        <property type="protein sequence ID" value="PPT15359"/>
        <property type="gene ID" value="CYQ11_22970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="716" mass="76245" checksum="1EFC14B280CB3D1C" modified="2018-01-31" version="1">MDTEGTTGSAYEASGTAAPRLPRQAGPPGTPPPLPPRPAGPPPAPAAGTEPPFLTWLRTPRPDAAAPGVWRFGHRPRPAQEPDRVPGRQLISGAVISLLCGWLLWSLLWNGYLGHYWIWPLFALTPDSWRQEGMFAVWVVYGYYTLCALVLVVVFGRLGRWAQVWQRWIAPALARLWDDSGDAPAAVPEPEQDPAQWPRLRAAGAHDAADRLAADARAGLMNDVDFARVERAWQSARDRPGRLAAFTDTVLRHGAAACAHPSGARDLPVRAARHDLVTGQVRLGAAVDDERNPYGHRGAGCALDPALLGTSLLAVGPPGCGKTGRLVRPVLESLCLQALAGRAAVVAVGAAGAGLAPDDAFDVVVKIGRPDSAYDIDLYGGTDDPDEAAAVLAEGLVGDLAAALPGGDGRRAATALAQLLGPYRAAHGRFPSVPELRELLDGDSPALDALRAALKAGGHETLARELDARERQAHRPGDPGPLLADRLALLDRPAFAGFFDTSAGDRAFSLRGLEHPLRVRVDLPERGHAEASRMLARLLLAQFAECAAGRTDRSLFACLVLDDATHTLTTETVRGLGRLRSAHAGAVLTLRTLDDVPEALRSALLGAVGCRMAFSGVTTWDGARFAEVWGKEWVETRDVTDRQIIAHEPITRVTHVVRRVITGRAVTAQSVTVRKVERERWSASELAHAVPAGHAVLSVTSVRGGSAPPVLVDLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCX3</accession>
    <name>A0A2G1XCX3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_23200</name>
        <name evidence="8" type="ORF">CYQ11_22875</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49009">
        <property type="protein sequence ID" value="PHQ49009"/>
        <property type="gene ID" value="BLA24_23200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15347">
        <property type="protein sequence ID" value="PPT15347"/>
        <property type="gene ID" value="CYQ11_22875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="366"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="570" mass="60057" checksum="63F777B1F3B5AF35" modified="2018-01-31" version="1">MVLARPEVTPATGRTTPKAGRAGARRTATRLGLMAVPLAFFGVFFAYPVASIVSRGLKDGGRWQFARAGEVLTDPAIGHVLWFTTWQAAASTALTLALALPGAYVFARFDFPGKRLLRAVVTVPFVLPTVVVGAAFLALLGHGGLLDELWGVRLDTTVWAILLAHVFFNYAVVVRTVGGLWAQLDPRQEEAARVLGAGRLGAWRRVTLPALAPAVAAAALMVFLFTFTSFGVVQILGGPRYATLEVEIYQQTAQLLDLPTAAVLTLVQFAAVAALLAVHARTVRRREATLRLVDAARTARRPRGAAEWTLLGSVLAVVALLVLLPLAVLVLRSFDGPDGYGLAFYRALGSAGAGGGTLVVPPLEAVGNSLAYALAATAIAVVVGGLAAAALTRREGRLVRGFDALLMLPLGTSAVTVGFGFLIALDEPPLDLRTSWILVPLAQALVGVPFVVRTVLPVLRAVDVRLREAAAVLGASPLRAWREVDLPLVGRALAVAAGFAFAVSLGEFGATVFIARPDSPTLPVAVARLVGRPGEFNYGQAMALSTILMLVCAVALLLLERVRTDRTGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCY6</accession>
    <name>A0A2G1XCY6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_23685</name>
        <name evidence="10" type="ORF">CYQ11_22390</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49088">
        <property type="protein sequence ID" value="PHQ49088"/>
        <property type="gene ID" value="BLA24_23685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15266">
        <property type="protein sequence ID" value="PPT15266"/>
        <property type="gene ID" value="CYQ11_22390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="45"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="34061" checksum="BECFC9F1021ADF26" modified="2018-01-31" version="1">MLGPVILAASRSDRMRRFVSAAPGTKQVVDRFIAGETVEQVIPIVKDAAAKGLEVTLDVVGEDITTVEQSYAARDAYLELIERLKELGLGTRAEMSVKLSMFGQALEGGHELALANVRPVVEAAAAIGTTVTLDAEDHTTLDSMFAIHEELRKDFPQTGCVIQAYLFRTEEDARRLAAAGSRVRIVKGAYKEPASVAYQDKAEIDKAFVRIIKILMAGSGYPMIGSHDPRLIAISQELALQAGRKLDEYEFQMLYGIRSDEHVRLAAEGHRMRVYTAYGTDWYGYFMRRLAEKPANLLFFARSILTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDB1</accession>
    <name>A0A2G1XDB1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="5">SHMT</shortName>
            <shortName evidence="5">Serine methylase</shortName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glyA</name>
        <name evidence="9" type="ORF">BLA24_24445</name>
        <name evidence="10" type="ORF">CYQ11_21625</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49218">
        <property type="protein sequence ID" value="PHQ49218"/>
        <property type="gene ID" value="BLA24_24445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15131">
        <property type="protein sequence ID" value="PPT15131"/>
        <property type="gene ID" value="CYQ11_21625"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="8">
        <location>
            <begin position="42"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="442" mass="45662" checksum="F649C351243DBFB0" modified="2018-01-31" version="1">MSVSPAPARGAAGTQRAREATRPARPPGPHASWEPGFAALLRQDPEIAGLLLAETERQATGLQLIAAENFASPAVLAALGSPLTNKYAEGYPGARHHGGCEMVDLAERLAVERAKELFGAGHANVQPHSGTAAVLAAYAALLEPGDTVLAMSLGQGGHLTHGSPANFSGRWFDFVGYGVREDTGLIDYEQVRALARQHRPKAIVCGSISYPRHPDYAAFREIADETGARLIVDAAHPIGLIAGGAAPSPVPYADVVCATTHKVLRGPRGGLILCGTRLAEAVDRAVFPFTQGGAQMHTVAAKAVAFAEAATPAFTAYAHQVVANARQLAAVLAAQGLVVATGGTDTHLVTADVSPLALDAATARGRLAAAGVVLDTCGLAQGTARGLRMGTAAVTTQGMGEAEMRRVGELLGAVLRGGGQERRVRAEVAELAGKFPPYRSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDB4</accession>
    <name>A0A2G1XDB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mce</name>
        <name evidence="3" type="ORF">BLA24_24270</name>
        <name evidence="4" type="ORF">CYQ11_21805</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49185">
        <property type="protein sequence ID" value="PHQ49185"/>
        <property type="gene ID" value="BLA24_24270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15165">
        <property type="protein sequence ID" value="PPT15165"/>
        <property type="gene ID" value="CYQ11_21805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="146" mass="16132" checksum="1F6F93B36B471381" modified="2018-01-31" version="1">MLTRIDHIGIACSDLDKTVEFYRATYGFEVFHTEVNEEQGVREAMLKINETSDGGASYLQLLQPTRDDSPVGKWLAKNGEGVHHIAFGTADVDTDSEAIRDKGVRVLYEQPRTGSMGSRITFLHPKDCHGVLTELVTSAPVAETDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC9</accession>
    <name>A0A2G1XDC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24615</name>
        <name evidence="3" type="ORF">CYQ11_21455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49247">
        <property type="protein sequence ID" value="PHQ49247"/>
        <property type="gene ID" value="BLA24_24615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15101">
        <property type="protein sequence ID" value="PPT15101"/>
        <property type="gene ID" value="CYQ11_21455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="231" mass="24198" checksum="6C2476D24332F600" modified="2018-01-31" version="1">MTAVSTRHGDDAPVTVERRDGPHGEVVLRRRGEHFEIIANGCFLMDTADGRSERRLVDAALAALPPDRPAPSVLIGGLGVGFSLARAVAEPRWGHVTVVERERAVVDWHRAGPLAAFSGGALADPRTEVVVGDLVAHLHAPGTRYDALCLDIDNGPDWTVTDDNGGLYSPAGLAACRARLTPGGVLAVWSAQPSPAFEEALRNAGFAGVTTEEITVARGVPDVVHLGVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF7</accession>
    <name>A0A2G1XDF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LytR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_24760</name>
        <name evidence="7" type="ORF">CYQ11_21310</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49273">
        <property type="protein sequence ID" value="PHQ49273"/>
        <property type="gene ID" value="BLA24_24760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15076">
        <property type="protein sequence ID" value="PPT15076"/>
        <property type="gene ID" value="CYQ11_21310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304722" evidence="3">
        <location>
            <begin position="33"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="89"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="365"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="495" mass="51511" checksum="59BAC3EB700CF07B" modified="2018-01-31" version="1">MTGRRGKSRRHRRMRIVTVVAVSFLVLLTAGAGWLYLRLNGNISTFDADGLSKNRPDAAAAGQNVLVIGSDSRAGDNSRLGGGEGDVGRSDTAFLLHVYDDREHAVAVSIPRDTLVDIPPCRLPDGGWTEERRHVMFNSAFSVGDTVKGNPACTQNTVERLTGLRVDHTVVVDFAGFSSMTSAVGGVEVCVPSDVYAGDLNPHLGRRGDLLFAKGRQHVSGQRALDYVRVRHGIGDGSDIGRIQRQQAFVSAMIKKVRSQGFNPGTLLPLADAATKSMTVDPGLGSAQKMLSFAMSLKKVDLRDMKFVTLPWRYDGNRVAIVQPEADALWAALKADRPLGGADPGPGRPSPSATPAAESVSGDGVKVYVLNGTDVSGLAARAAASLEGHGFTVTGTATARGRDAATTVIEFGPGEAAGARTLARLFPGAYVRGTAGSGVALTLGRDYAAAPAASPSTGPSSAAPSGTPAPGLLSADALEKPRSADDDPCANLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF8</accession>
    <name>A0A2G1XDF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superoxide dismutase, Ni</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sodN</name>
        <name evidence="1" type="ORF">BLA24_24720</name>
        <name evidence="2" type="ORF">CYQ11_21350</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49266">
        <property type="protein sequence ID" value="PHQ49266"/>
        <property type="gene ID" value="BLA24_24720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15082">
        <property type="protein sequence ID" value="PPT15082"/>
        <property type="gene ID" value="CYQ11_21350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="131" mass="14858" checksum="D2C647FE2E4B4C66" modified="2018-01-31" version="1">MLSRLFAPKVKVSAHCDLPCGVYDPAQARIEAESVKAVQEKYQANEDPAFRSRAILIKEQRAELAKHHVSVLWSDYFKPPHFEKYPQLHQLVNDTLKALSAAKASTDPKTGEKALELIAEIDRIFWETKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDL3</accession>
    <name>A0A2G1XDL3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25070</name>
        <name evidence="4" type="ORF">CYQ11_21000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49327">
        <property type="protein sequence ID" value="PHQ49327"/>
        <property type="gene ID" value="BLA24_25070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15025">
        <property type="protein sequence ID" value="PPT15025"/>
        <property type="gene ID" value="CYQ11_21000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="580" mass="60183" checksum="95204FC1E9549A01" modified="2018-01-31" version="1">MSREFQRGHKAKITDLTAGTDLYVGVQIGGPGLTFDISCFGLDADERLSDDRYFVFFNQPKSPEEAVQQLGAQAGDTESFRVTLDRVPAHIRKLTFTATLDGAGQMSQVGPGYLRVVAGGVEVARYSFTGAEFSTERAVMLGDLYLKDVWRFAAVGQGFDGGLEALLRNFGGEVLEEEEPAPAAGAPAAAPSFAPPAQASAPPAFAPPGAAAAAASPAPQAPAPAPAHSFAPPPGSTPPPVPPAASQQVHAAPTLAAPIAPPGHFSGGQTPPRGVVAPPGPPGVPGQHAPYGQPPPPPQAPPAHQSYGAPVVPAQPYPGAQQAAPYGQPGHPGQQPYGHPAQPAPAPYGAPGAHAAPGPAVPGVQAALEKYREAPNGQRWTPQNAKLIRVDLGADPQPVLARQGSMVLYQGKVDFSYKGAGVMSRIVGNATGQEMQLMRCTGRGQVFLAENSAHVHPIQLENEAICVSADAVLAFDESLHYEVRRIEGHGIPGGALFTMQFQGMGTVVVKTHGTPVVLPVTPTTYADSNAIVAWSAGAQVIVSSQVRLRRNSYPGYSGEAVNLQFRGAPGNFIVVQPYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDR4</accession>
    <name>A0A2G1XDR4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25355</name>
        <name evidence="4" type="ORF">CYQ11_20720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49377">
        <property type="protein sequence ID" value="PHQ49377"/>
        <property type="gene ID" value="BLA24_25355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14974">
        <property type="protein sequence ID" value="PPT14974"/>
        <property type="gene ID" value="CYQ11_20720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="25133" checksum="F11725EB868622ED" modified="2018-01-31" version="1">MTGSGGQSPAEQHLGDRLAALVDGELGHDARERVLAHLATCGKCKAEADAQRRIKNVFAQAAVPPVSDALLARLQGLPGEMTGEPADGGPGPGDARGRGFGARAEAFAFLPAVTVQPGDGGFRIHDFERGPGVRAGSRGRRFAFAAAGTVSLAALALVGAQPLGTAVETPRARGGGQSSVTTTSLAMSQGLGGQSDSVRTPAATAFSPVALLRPSGAPVHPPLIRTSLARTATPPERSRAQSGRAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDU2</accession>
    <name>A0A2G1XDU2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sec-independent protein translocase protein TatB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tatB</name>
        <name evidence="10" type="ORF">BLA24_25345</name>
        <name evidence="11" type="ORF">CYQ11_20730</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TatB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49375">
        <property type="protein sequence ID" value="PHQ49375"/>
        <property type="gene ID" value="BLA24_25345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14976">
        <property type="protein sequence ID" value="PPT14976"/>
        <property type="gene ID" value="CYQ11_20730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00237">
        <property type="entry name" value="TatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="16225" checksum="D05E571674BB40EA" modified="2018-01-31" version="1">MLDIGPLELVSLVVLAVLIFGPDKLPKLIQDVSRTLRKIRQFSENAKHDIRSELGPEFKDFEFEDLNPKTFVRKHVLEKDELGLKEIRNGFDFKAEMADVTDAVHGRTPDPVAGSSASSGASGTPDLLKKAEKIQPGERPPFDADAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE55</accession>
    <name>A0A2G1XE55_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26190</name>
        <name evidence="3" type="ORF">CYQ11_19450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49524">
        <property type="protein sequence ID" value="PHQ49524"/>
        <property type="gene ID" value="BLA24_26190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14756">
        <property type="protein sequence ID" value="PPT14756"/>
        <property type="gene ID" value="CYQ11_19450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="9694" checksum="F1DEB163D1B560C4" modified="2018-01-31" version="1">MTEDTPAPGRPQRRKQVLLRLDPLVHDALARWADDELRSANAQIEFLLRKALSEAGRLPRDVGAIRRRGRPSKGDRTGPDEGGGAAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE59</accession>
    <name>A0A2G1XE59_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26185</name>
        <name evidence="5" type="ORF">CYQ11_19455</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49523">
        <property type="protein sequence ID" value="PHQ49523"/>
        <property type="gene ID" value="BLA24_26185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14757">
        <property type="protein sequence ID" value="PPT14757"/>
        <property type="gene ID" value="CYQ11_19455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="77"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="309" mass="32788" checksum="6808675D462A9474" modified="2018-01-31" version="1">MSDTTTENPPAAPRPGIEERPANDIGGGLALLLGLVGLLAGVAAVAVGAGSHLADGLRFALIAGGVLAGLGSVVAMSGLNTIAPGQANVVQLFGRYRGTIRNEGLRWVNPFTSREKISTRVRNHETAVLKVNDAYGNPIELAAVVVWCVEDTAQAMFAVEDFQEFVATQTEAAVRHIAIEYPYDAHDENALSLRGNAEEITEKLALELHARVAAAGVRIIESRFTHLAYAPEIASAMLQRQQAGAVVAARKLIVEGAVGMVEQALERISEQGFVELDEERKAAMVSNLMVVLCGDRAAQPVLNTGTLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE76</accession>
    <name>A0A2G1XE76_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26285</name>
        <name evidence="3" type="ORF">CYQ11_19355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49540">
        <property type="protein sequence ID" value="PHQ49540"/>
        <property type="gene ID" value="BLA24_26285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14740">
        <property type="protein sequence ID" value="PPT14740"/>
        <property type="gene ID" value="CYQ11_19355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="21803" checksum="CFBDD0B83A8FA918" modified="2018-01-31" version="1">MDAKEPADTGLAETLAGIGPRLRALRRDRGLTLEALAEDTGISVSTLSRLESGKRRPTLDLLIPLARTHRVALDQLVAAPATGDPRVHLKPHRRERGNVLVPLTQYPGRVQVFKQVLAYREPKLVTHAGYEWLYVLAGELRLILGEREFTLRPGEVAEFDTGEPHWFGPADKNAVEILHLFGPRGDQAVVRTGPSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL9</accession>
    <name>A0A2G1XEL9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sdhC</name>
        <name evidence="9" type="ORF">BLA24_26950</name>
        <name evidence="10" type="ORF">CYQ11_18685</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49655">
        <property type="protein sequence ID" value="PHQ49655"/>
        <property type="gene ID" value="BLA24_26950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14623">
        <property type="protein sequence ID" value="PPT14623"/>
        <property type="gene ID" value="CYQ11_18685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="14323" checksum="F003AF291E651CE6" modified="2018-01-31" version="1">MPAGTLYRGREGMWSWVAHRVTGVLIFFFLFVHVLDTALVRVSPEAYDEVVATYKTPIVNVMEYGLVAAILFHALNGLRVIAVDFWSKGPRYQKQMLWSVVMVWALLMAGAFYPVLQHTLRTLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEN0</accession>
    <name>A0A2G1XEN0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_23865</name>
        <name evidence="7" type="ORF">CYQ11_22205</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49704">
        <property type="protein sequence ID" value="PHQ49704"/>
        <property type="gene ID" value="BLA24_23865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16720">
        <property type="protein sequence ID" value="PPT16720"/>
        <property type="gene ID" value="CYQ11_22205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="357" mass="39395" checksum="1A546D48BE3C4913" modified="2018-01-31" version="1">MGEPVSGGGAPTAFLDVRDLRVHFPTDDGLVKSVDGLSFQLEKGRTLGIVGESGSGKSVTSLGIMGLHTVGQYGRRKARISGEIWLDGTELMGADPERVRRLRGREMAMIFQDPLSAMHPYFTVGAQIVEAYRVHHDVDKKTARRRAVELLDRVGIPQPDRRVDDYPHQFSGGMRQRAMIAMALVNNPDLLIADEPTTALDVTVQAQILDLIRDLQTEFGSAVIIITHDLGVVAELADDILVMYGGRCVEQGPAEQVFHEPQHPYTWGLLGSMPRIDREQTERLIPVKGSPPSLINLPAGCAFNPRCPYADVPPGGVTRTERPELRLVPGRERHLSACHMAPQERTRIWTEEIAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEP8</accession>
    <name>A0A2G1XEP8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnD</name>
        <name evidence="11" type="ORF">BLA24_23345</name>
        <name evidence="12" type="ORF">CYQ11_22730</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49692">
        <property type="protein sequence ID" value="PHQ49692"/>
        <property type="gene ID" value="BLA24_23345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16732">
        <property type="protein sequence ID" value="PPT16732"/>
        <property type="gene ID" value="CYQ11_22730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="10">
        <location>
            <begin position="439"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="629"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="741"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="811" mass="86046" checksum="CD6AD491F6F2F6B6" modified="2018-01-31" version="1">MDRAGSTAGGTGGKDATAPETGGYAATRLRLLHREDLSGPPLRTALARLTDDWLATLLGPAEGVALVAVGGYGRGELSPRSDLDVLLLHDGTAMSQIAALADRVWYPVWDMGLALDHSVRTPAEARRTAAGDLKVHLGLLDARHLAGDPALTAALRTTAYEDWRAQAPARLPELRELCEERARRQGELRFLLEPDLKEARGGLRDATALRAVAASWLADAPREGLDRARALLLDTRDALHRVTGRATDRLALQEQEQVARRLGLADADTLLREVYEAGRTVSYATDVTWREVTRVLRSRSGRPRLRRILGGRGGRGGFVQPQRVPLAEGVVEQDGEAVLARTARPEHDPVLPLRAAAAAAQAGLPLSPPTVRRLAAAGPLPVPWPAEAREQLVTLLGAGEPTVAVWEALEAEGLVSRLLPEWAHVRCRPQRNPVHRWTVDRHLVETAVRASALTRRVGRPDLLLMAALLHDLGKGHPGDHSEAGETLARALAPRLGFDGADTDVLATLVRHHLLLAETATRRDLDDPATIRAVTDAVGSAGTLELLHALTEADALATGPAAWSTWRASLVADLVRRAGAALAGRPVAARTEPAPPTAGEERLAIEALRTAGPVVALEPPPEGAGQDSVELTVAVPDQPGVLPATAGVLALHRLTVRAAEVRAVAPAPAVGSALLLNWRVAAEYGSPPEAARLRNDLVRALDGSLDVAARLAEREAAYGRRRVVHAPPRVSVVEGVSRAATVLEVRAQDAPGLLHRIGRALEDAGVWVRSARVSTLGASVVDAFYVTGAEGGVLDPEEAAAVARKVRESLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XET6</accession>
    <name>A0A2G1XET6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26080</name>
        <name evidence="2" type="ORF">CYQ11_19985</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49743">
        <property type="protein sequence ID" value="PHQ49743"/>
        <property type="gene ID" value="BLA24_26080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16683">
        <property type="protein sequence ID" value="PPT16683"/>
        <property type="gene ID" value="CYQ11_19985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="102" mass="10738" checksum="0087FF17CB337DFC" modified="2018-01-31" version="1">MLELGDDSLEAHREIGRYAAEQGVEILLGVGNSPNVKQLVLHAGAAGVPNLALVADNETAADFLEKILVPGDKVLMKASRGGMLWQIAQRLTGQPVTGLGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF06</accession>
    <name>A0A2G1XF06_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">BLA24_19355</name>
        <name evidence="9" type="ORF">CYQ11_11445</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49810">
        <property type="protein sequence ID" value="PHQ49810"/>
        <property type="gene ID" value="BLA24_19355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13414">
        <property type="protein sequence ID" value="PPT13414"/>
        <property type="gene ID" value="CYQ11_11445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="25781" checksum="9C05BAF70A2B063A" modified="2018-01-31" version="1">MIRFDNVSKSYPKQNRPALRDVSLEIEKGEFVFLVGSSGSGKSTFLRLLLREERATHGQVHVLGKDLARLSNWKVPQMRRQLGTVFQDFRLLPNKTVSQNVAFALEVIGKPRGEIRKAVPQVLELVGLGGKEERMPGELSGGEQQRVAIARAFVNRPMLLIADEPTGNLDPQTSVGIMKLLDRINRTGTTVIMATHDQQIVDQMRKRVIELEQGRLVRDQSRGVYGYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD9</accession>
    <name>A0A2G1XFD9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_20045</name>
        <name evidence="8" type="ORF">CYQ11_10745</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49921">
        <property type="protein sequence ID" value="PHQ49921"/>
        <property type="gene ID" value="BLA24_20045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13303">
        <property type="protein sequence ID" value="PPT13303"/>
        <property type="gene ID" value="CYQ11_10745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="328" mass="36172" checksum="F386BD488AD6AB61" modified="2018-01-31" version="1">MTATTSVAEDARAAPGERGGGRSRPGPWRGRLYRWDLRYSPYAFVAPFLLFFAAFGLFPLLYTGWASLHRVELTSLHHTEWAGAHHYVRLLENDFFWNALRNTFTIGVLSTVPQLLMALGLAHLLHHRLRAATFWRVALLTPYATSVAAATLVFVLLYGRDYGMVNWALGALGIGPVDWQNGTWSSQCAVASIVIWRWTGYNALIYLAAMQAVPDELYESAALDGASRRQQFRHVTVPALRPTILFTVVVSTIGATQLFGEPLLFGGAAGQKGGASHQFQTLGLYLYEQGWFNYHLGRASAVAWTMFLLLLLIAAVGGLVARRRGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS7</accession>
    <name>A0A2G1XFS7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_20455</name>
        <name evidence="2" type="ORF">CYQ11_10330</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49989">
        <property type="protein sequence ID" value="PHQ49989"/>
        <property type="gene ID" value="BLA24_20455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13234">
        <property type="protein sequence ID" value="PPT13234"/>
        <property type="gene ID" value="CYQ11_10330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="125" mass="14090" checksum="E7FB0828FDC35BF2" modified="2018-01-31" version="1">MTNIPPPRRLHHAIRDLLARHRLAIHYWAGWVSTSRSGRTVGPWPVLALHRLPDPDCTTCGGQGEVTCAGPDVDEPGYDDCHCAPFQPLAFIWLPKIPRFPRRRRPAAHDSWCTDPACAHDQLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFT4</accession>
    <name>A0A2G1XFT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HTTM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_20925</name>
        <name evidence="9" type="ORF">CYQ11_09855</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50065">
        <property type="protein sequence ID" value="PHQ50065"/>
        <property type="gene ID" value="BLA24_20925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13154">
        <property type="protein sequence ID" value="PPT13154"/>
        <property type="gene ID" value="CYQ11_09855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="7">
        <location>
            <begin position="37"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="42772" checksum="A2A30FA90ECA10C2" modified="2018-01-31" version="1">MTTDRTTGADAWPDSPPPSAASRHPDPVTRAFAFLTERAVSLHAAAVLRMGYGLLYLVFLLREFPHRDEIWGPGSPWTPDLSRELTAQTGWFTFLPLSDRPVYFETCYGLALVTCALFMLGWRTRVLSVLFAVVVTSFHGRNIFITDGGDNLIVLMALYLMFTACGRRWSLDARRKRLRARADGRGHQRSSWLPARQQDVLVRGQLSVLLHNCGMFVIAAQVCILYGCAGLYKVQGGTWRDGTALHYVLNLDLFRPWPGLSHLADSHQLLMAVVGYLTVLVQVACPFALFSRAKYVVLVLLIGMHVAIAVMLGLPVFSGAMIIADTVFLPDRFFQFLQRAWRARLSRPAGEATVPRARTGSLVPPRAGAPVAARHAQEKVPDQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFU5</accession>
    <name>A0A2G1XFU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20575</name>
        <name evidence="3" type="ORF">CYQ11_10205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50009">
        <property type="protein sequence ID" value="PHQ50009"/>
        <property type="gene ID" value="BLA24_20575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13213">
        <property type="protein sequence ID" value="PPT13213"/>
        <property type="gene ID" value="CYQ11_10205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304614" evidence="1">
        <location>
            <begin position="36"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="449" mass="49207" checksum="C779FF40BD062B6A" modified="2018-01-31" version="1">MPRSRRRLPPTVLLPLLMIAGLLLPGCANPGAGSAADDPTRPVTLRFWHGWSEKREVKAIDDSLARFHRLHPNIRVKTTGNVTDATVNQALRAGGGAAPDVVSSFTTNNVGQYCSSGMWVDLDPFLAKSGVDKTAVFPRTLLDYSAYEGRQCALPLLADAYGMYYNLDAFEKAGVSRAPRTLSELKETAVKLTERAADGSYRQLGFMPNLRLYQNSVDRFFAQWGPRYFDDKGKSALAREPATKRFLTTQRDLVTALGGYGPLETFRATFGEEMSSQNAFLTGKLAMHMDGEWRGLMLAKAAPGFRWATAPMPVPDDRADTYGRGYLTGTVAGIAHSSKHQNAAWELVKFLTTDTDQVVAFANAIHNVPSTNAALASPRLDADPAFQTFLRIARDPRSTGMPPSVNGGQYIVTFQDFAYDVEAGKVRDLDKGLRALDRQIDDDNLQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG08</accession>
    <name>A0A2G1XG08_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3145 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21595</name>
        <name evidence="2" type="ORF">CYQ11_09190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50172">
        <property type="protein sequence ID" value="PHQ50172"/>
        <property type="gene ID" value="BLA24_21595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13045">
        <property type="protein sequence ID" value="PPT13045"/>
        <property type="gene ID" value="CYQ11_09190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="164" mass="18017" checksum="070F9A05849DB284" modified="2018-01-31" version="1">MTTRGVLFVHSAPRALCPHVEWAVAGVLGVRVALDWIRQPAAPGTWRSEFSWQGQPGTASKLASALRGWHLLRFEVTAEPCATAEGERYSSTPDLGIFHAVTGMHGDILIPEDRLRAALCRADKGETDLPAELAKLLGKPWDDELEPFRYAGEGAPVRWLHQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGH9</accession>
    <name>A0A2G1XGH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50343">
        <property type="protein sequence ID" value="PHQ50343"/>
        <property type="gene ID" value="BLA24_22645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="252" mass="26754" checksum="66E56980DE31F4AF" modified="2018-01-31" version="1">MAEGARGLRNTVRQELVARQVDEQIAARFPVGRRLRVLDVGPGQGTQALRLARAGHEVTGLESDPRMLDAVRGALAGEPEGIRERVRLVEGDGREAGAHFLPGAFDVVLCHGVLMYVPEPDPMLAGLARVLAPGGLLSLLVRNADALAMRPGLAGDWDTALAAFDSPAYTNRIGLEVRADRRETLTATLAGIGAPLHAWYGVRVFCDLAPDEAPPPSGAELERLLAAEDRAGRTDPYRAVAALLHLCGVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGM5</accession>
    <name>A0A2G1XGM5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_20985</name>
        <name evidence="10" type="ORF">CYQ11_09795</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50394">
        <property type="protein sequence ID" value="PHQ50394"/>
        <property type="gene ID" value="BLA24_20985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16459">
        <property type="protein sequence ID" value="PPT16459"/>
        <property type="gene ID" value="CYQ11_09795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="76"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="40097" checksum="9C4E7698E7C255FE" modified="2018-01-31" version="1">MTESTSDGGERERAGSRRRFPGISSRAYEHPADRSALVALRKLSGFDTVFKALSGLLPERSLRLLYLSDSVRVSEQQFPHLHTMLLDACYVLDLERVPAMYVTQNPQPNAMCIGLDEPLIVVSTGLVELLDDEEMRAVVGHEVGHALSGHAVYRTILLFLSNVALKVAWIPLGNIAVTALVTALREWFRKSELSADRAGLLACQDLRASMRGLMKIAGGNHLHEMNVDAFLAQAEEYERAGDLRDSVLKIMNVLPRSHPFAAVRAAELKKWAESRDYQRLMDGHYPRRSEDKDASVSDSFRESASHYAESVRASKDPLMGLVRDIAGGAGDLGGRLRDTFTGRRPSPPGDGKEGPGGPGGADGSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGM6</accession>
    <name>A0A2G1XGM6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50383">
        <property type="protein sequence ID" value="PHQ50383"/>
        <property type="gene ID" value="BLA24_20490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="55"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="593" mass="61988" checksum="C1A8CA58333B3C8B" modified="2018-01-31" version="1">MTSPAGQALRPRLDALRELVGLSRARLDRRTLAEAGRVLEEAAARQRHSLDLTVVAIAGATGSGKSTLFNALARAQLSEAGVRRPTTAMPVSCAWTDRADGLLDRLGIPARARRQPVRPYDPTLSGLVLLDLPDHDSAATGHREQVDRLLGLVDAVIWVVDPEKYADAVLHERYLRPLAGYAEVTFVVLNQVDRLTGDAADQVLDDLRRLLDEDGLALGEHGEPGAAVLALSALTGAGVGELREALGLFAARRCAAEMRLTADVDGVSSRLRAAYVADGRPGLTEWARQEFEDRLAEAVGAQAAGLAAERAWRREAERACGSSWARLRMWCERRGKGAPGTAGDGAGDGEQTLVAGVPVPRRTASRPLVERAVRALAYEASAGLPGPWAQAVREAAGRGAEGLAEALDEIAASAAADMVAGAAAGARRPGGGGAGGRHGGGGRTGSWRTGAGHVAPEAEDSGRATLRRGRAAGAGASERPRWWRALATGQKTLLAVQLLGTAWFAGACVGELGGPWWGPGALMVGGAATAPVLGWGGRLAARGPARGFGLETERRLRSAAAVCGRARVLEPVVAELLRYREVRAQYVIAAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGY6</accession>
    <name>A0A2G1XGY6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acs</name>
        <name evidence="5" type="synonym">acsA</name>
        <name evidence="9" type="ORF">BLA24_16850</name>
        <name evidence="10" type="ORF">CYQ11_16435</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50500">
        <property type="protein sequence ID" value="PHQ50500"/>
        <property type="gene ID" value="BLA24_16850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14245">
        <property type="protein sequence ID" value="PPT14245"/>
        <property type="gene ID" value="CYQ11_16435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="91"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="535"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="391"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="415"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="655" mass="71629" checksum="6807469E741610BE" modified="2018-01-31" version="1">MSNESLANLLKEERRFAPPAGLAEKANVTAEAYEQATADRLGFWAAQARRLSWETEPTETLDWSNPPFAKWFADGKLNVAYNCVDRHVENGLGDRVALHFEGEPGDSRSITYAQLQREVSQAAHALTELGVQAGDRVAIYLPMIPEAVVSMLACARIGAPHSLVFGGFSADALATRINDADARVVITADGGFRRGKPSALKPAVDEALTRPGTENVRSVLVVRRTGQEDIAWTEGRDVWWHDLVARQPEQHTPEAFDAEHPLFILYTSGTTGKPKGILHTSGGYLTQSSYTHHAVFDLKPETDVFWCTADVGWVTGHSYIVYGPLSNGATEVIYEGTPDSPHQGRWWEIVQKYGVTILYTAPTAIRAAMKWGDDIPARFDLSSLRVLGSVGEPINPEAWVWYRKHIGADVTPVVDTWWQTETGSIMISPLPGVTEAKPGSAQVPLPGIAATVVDDDGHEVPNGSGGYLVLTEPWPSMLRTIWGDDQRYLDTYWSRFEGRYFAGDGAKKDEDGDIWLLGRVDDVMLVSGHNISTTEVESALVSHPKVAEAAVVGANDPQTTQAICAFVILRGNVNSEEEGLVEELRAHVAKQLGPIAKPKRILPVAELPKTRSGKIMRRLLRDVAENRTLGDVTTLTDSSVMDLIQAKLPAASSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH34</accession>
    <name>A0A2G1XH34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17205</name>
        <name evidence="4" type="ORF">CYQ11_16070</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50554">
        <property type="protein sequence ID" value="PHQ50554"/>
        <property type="gene ID" value="BLA24_17205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14192">
        <property type="protein sequence ID" value="PPT14192"/>
        <property type="gene ID" value="CYQ11_16070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304870" evidence="2">
        <location>
            <begin position="32"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="320" mass="33394" checksum="33BD08ADEB086888" modified="2018-01-31" version="1">MSFTSRIAPRRRTLVAAGTAVVLAVTLAACGSSKDSDSSMPGMDHGAHPSASSSSPSASASGMDHGHGSTSGMDHGGMDHAGMGDGLADTKDGYKLTSTATELPAGKDSAYSFQITGPDGKPVTAFAVDQTKRMHFYAVRADLTGFQHLHPSMTDDGTWTAALTALQPGTWRTYASFTPDDGPGKGKDFVLSRTVTVPGAAEKTPLPQATTSTEVDGYTVTVKGVLMAGMAHPATVSISKDGEPVTDLQPYLDTYAHLTAFHEGDQAFAHLHPETKVTGDHGGPDLSFQAMLPKPGNWRMFLQFQTGGKLHTAALTLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH54</accession>
    <name>A0A2G1XH54_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17325</name>
        <name evidence="4" type="ORF">CYQ11_15950</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50574">
        <property type="protein sequence ID" value="PHQ50574"/>
        <property type="gene ID" value="BLA24_17325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14172">
        <property type="protein sequence ID" value="PPT14172"/>
        <property type="gene ID" value="CYQ11_15950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="28817" checksum="9E54435626B868A3" modified="2018-01-31" version="1">MASGVRADSSRVSVWLDGGTTPKRKAAAEGEAGEGALDRERIVAATVRLLDAEGLAKFSMRRLAAELGVTAMSVYWYVANKDDLLEYALDHVCAGIALPDAADESTDWREQLRVLAAGYRRQLLRHPWVPQLLGRYLNIGPNAMEFSNAVIGVMRRTGLPDESMAGALSALFQFVYGFTSSEVLYNENCRRSGVSQDDHYRQTLKTIEERPDFTEKYRDAMKLAESRFSMSVADMFERDFSVAVDTVIAGIEAMRDRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHH9</accession>
    <name>A0A2G1XHH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50704">
        <property type="protein sequence ID" value="PHQ50704"/>
        <property type="gene ID" value="BLA24_18125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="193" mass="21000" checksum="DA2DD77205AFFE55" modified="2018-01-31" version="1">MASLVIAAAIRWPSLFLAPSDPQAQPAGRRRWKSPPRPGTPDLIVPPGKRSPGMNDALERVRKAAPEAVQHGPCGQRRFALIPRVREEISAVIEDHALAEAESRELRHAAQTCSTYVLGSHPPPVARRPGSLGRLVLHCAAGIVPGPARWQEEWASEYAAMSGYPLSARVRFLAGLLLAAPRLAWSLGRRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHM8</accession>
    <name>A0A2G1XHM8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18290</name>
        <name evidence="2" type="ORF">CYQ11_14985</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50733">
        <property type="protein sequence ID" value="PHQ50733"/>
        <property type="gene ID" value="BLA24_18290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14011">
        <property type="protein sequence ID" value="PPT14011"/>
        <property type="gene ID" value="CYQ11_14985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="154" mass="16521" checksum="9BDBECEB6107B9B2" modified="2018-01-31" version="1">MQPAVSPPSASPAAARDERRALELLSGTPYGRISVSMRALPFVTVARHVVADGKVLLRLHGGFGYARACDGSVVAYGADNLAEREEGDESVWTVQFVGTARVFRPDAAQLELFGRAPRSADAAPFVPEYLCIEPQFITLHHLEGVPARRAAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHU5</accession>
    <name>A0A2G1XHU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18470</name>
        <name evidence="4" type="ORF">CYQ11_14810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50761">
        <property type="protein sequence ID" value="PHQ50761"/>
        <property type="gene ID" value="BLA24_18470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13981">
        <property type="protein sequence ID" value="PPT13981"/>
        <property type="gene ID" value="CYQ11_14810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304872" evidence="2">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7023" checksum="C11E0720F546B04E" modified="2018-01-31" version="1">MRRPVLAARTRIAVAHGAVFLVLGTGLPATVTVLSRAGTQEWRDGEGRPPGGKRPSRGGGTGAGTACGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHU9</accession>
    <name>A0A2G1XHU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2617 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18680</name>
        <name evidence="2" type="ORF">CYQ11_14600</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50797">
        <property type="protein sequence ID" value="PHQ50797"/>
        <property type="gene ID" value="BLA24_18680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13945">
        <property type="protein sequence ID" value="PPT13945"/>
        <property type="gene ID" value="CYQ11_14600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024486">
        <property type="entry name" value="DUF2617"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10936">
        <property type="entry name" value="DUF2617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="172" mass="18569" checksum="86DB8417199593DF" modified="2018-01-31" version="1">MLTTLKTAYTDTRAADLAWCLGKEPLPALAVLDLHLAGSAVQLRLLGASHQVILEEDDGLCSETVACIPGSQTPLPLGVAKRVGAWEYEFAARVETLSPCSFAGRAQELLALVAEHPHGLAGTFPGSPHAFTALLAQRSDGQMSWRTWHAYPQERRLVTTRTRVGVRMTAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHW6</accession>
    <name>A0A2G1XHW6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid degradation protein PaaN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">paaN</name>
        <name evidence="3" type="ORF">BLA24_18210</name>
        <name evidence="4" type="ORF">CYQ11_15065</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50719">
        <property type="protein sequence ID" value="PHQ50719"/>
        <property type="gene ID" value="BLA24_18210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14027">
        <property type="protein sequence ID" value="PPT14027"/>
        <property type="gene ID" value="CYQ11_15065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011975">
        <property type="entry name" value="PaaN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02288">
        <property type="entry name" value="PaaN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="95"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="567" mass="60020" checksum="C432EFBA60190902" modified="2018-01-31" version="1">MTAGLTTAQLIEKHRPTLDQALEAIRTRAYWSPYPEHPKAYGADGVPGSLDAAAGQAAFDALRGRRFELDQPGTDGWTGSEVSPYGLELGVEYPHADIDVLLPAMRAAMPAWRDAGALVRAAVCAEVLARINARTHEFAHAVMHTSGQAFMMALQAGGPHAQDRGLEAVAYAYAEQSGAAPESAEWVKPQGKRDPLKLDKEFTPVPRGVSLLIGCNTFPTWNGYPGLFASLATGNPVLVKPHPRAVLPLALTVRIAREVLAEAGFSPDLVTLAAERDGEGVAKTLAVRPEVRVIDYTGSTAFGDWLEANARQAQVFTEKAGVNTVVVDSTDDYKGMLSNLAFSLSLYSGQMCTTPQNLLIPREGIATDAGHKSYDEVVADLATAVDKLLGDDARANALLGAIVNDQVKARIDAAAQLGEVALASRTVANPDFPGATVRTPVIVKLDGAKPDAEAAYFSECFGPVSFAVAVDSTADAVELLRRTVREKGAMTVGAYTTSADAERLIETACLEECAQLSLNLTGGVYVNQTAAFSDFHGSGGNPAANAALCDSAFVAPRFRVVEVRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI08</accession>
    <name>A0A2G1XI08_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">nth</name>
        <name evidence="13" type="ORF">BLA24_16885</name>
        <name evidence="14" type="ORF">CYQ11_16400</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50866">
        <property type="protein sequence ID" value="PHQ50866"/>
        <property type="gene ID" value="BLA24_16885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16606">
        <property type="protein sequence ID" value="PPT16606"/>
        <property type="gene ID" value="CYQ11_16400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="12">
        <location>
            <begin position="54"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ50866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT16606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="29093" checksum="8EB4AA8D93B0B02C" modified="2018-01-31" version="1">MAEAVATEPARAESRTALVRRARRINRELADVYPYAHPELDFENPFQLLVATVLSAQTTDLRVNQTTPALFAAYPTPEDMAAADPETLEQLIRPTGFFRAKAKSLIGLSVALRDRFDGEVPGRIADLVTLPGVGRKTANVVLGNAFGVPGVTVDTHFGRLVRRWKWTVAEDAEKVEAEVCSLFPKSEWTMLSHRVIFHGRRVCHSRRPACGACPIAPLCPSYGEGETDPEKAKKLLKYEMGGQPGQRLKPPPDYPGLPARPLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI16</accession>
    <name>A0A2G1XI16_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Valine dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_18905</name>
        <name evidence="15" type="ORF">CYQ11_14375</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:30763"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.23" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50831">
        <property type="protein sequence ID" value="PHQ50831"/>
        <property type="gene ID" value="BLA24_18905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13911">
        <property type="protein sequence ID" value="PPT13911"/>
        <property type="gene ID" value="CYQ11_14375"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043837">
        <property type="term" value="F:valine dehydrogenase (NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="13">
        <location>
            <begin position="157"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ50831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT13911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="38837" checksum="2B6796948D718467" modified="2018-01-31" version="1">MTDVRPTTDADGVLRTLFRSDQGGHEQVVLCQDRESGLKAVIALHSTALGPALGGTRFYPYASEEEAVRDALNLSRGMSYKNALAGLDHGGGKAVIIGDPDLIKTEQLLLAYGRFVASLGGRYVTACDVGTYVRDMDVVARENPWTTGRSPENGGAGDSSVLTAFGVFQGMRAAAQAQWGEPTLRGRRVGVAGVGKVGHHLVEHLVEDGAEVVVTDVRTEAVERITGRHPQVTAVTDADVLIRTPLDVYAPCALGGALNDETVAALTATVVCGAANNQLAHPGVEKDLADRGILYAPDYLVNAGGVIQVADELHGFDFDRAKAKAAKIFDTTLAIFDRAKADGIPPAVAADRLAEQRMAEARAARTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI70</accession>
    <name>A0A2G1XI70_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19060</name>
        <name evidence="4" type="ORF">CYQ11_14220</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50923">
        <property type="protein sequence ID" value="PHQ50923"/>
        <property type="gene ID" value="BLA24_19060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16553">
        <property type="protein sequence ID" value="PPT16553"/>
        <property type="gene ID" value="CYQ11_14220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="441" mass="48008" checksum="69D1BD5EADD7C81B" modified="2018-01-31" version="1">MLIVGGGYVGLFTALRLQRKLRRGEAEIVVIDPEPYMTYQPFLPEAAAGSISPRHVVVPLRRVLDKCEVVIGEATAIDHAKRTATVKTLATEEEGTGAITVPYDELILAPGSVSRTLPIPGLADYGIGFKTVEEAIGLRNHVLEQLDIASSTRDPEVRDAALTFVFVGGGYAGVEALGELEDMARYAARYYHNVSPDDLRFVLVEATDRILPEVGRDMGRYAVRELRGRNIDVRLGTRLDSCENRVAVLSDGSRLPTRTLVWTAGVKPHPVLAATDLPLDGRGRLVCTTALKVDGVDHAWAAGDAAAVPDLTATEPGRECAPNAQHAVRQTKVLAQNVLSSLRGKDLKDYRHKYVGSVASLGLHKGVAQVYGTKLKGYPAWFMHRAYHLSRLPTFNRKARVLAEWILAGLFKREIVSLGSLENPRAEFELAAGTGRHPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIC1</accession>
    <name>A0A2G1XIC1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14115</name>
        <name evidence="3" type="ORF">CYQ11_13960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50931">
        <property type="protein sequence ID" value="PHQ50931"/>
        <property type="gene ID" value="BLA24_14115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13849">
        <property type="protein sequence ID" value="PPT13849"/>
        <property type="gene ID" value="CYQ11_13960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="19496" checksum="62D87F2A779C8589" modified="2018-01-31" version="1">MEIPSPYGASESTGDTHTLRYELSIPYPVDEVWAAVATPEGLPSWLAVAEPFEQREGGAITLRWQNTDPQGHATVAPGRVTAWDPPRLVEYTVDIHGRVRFELEPGPLGVGGTLLHFTNELAGTDDVRLDCLAGWHHHFEYLLQALGGHPADWSQWTLDRWRELRGRYERGDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG4</accession>
    <name>A0A2G1XIG4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoI</name>
        <name evidence="7" type="ORF">BLA24_14350</name>
        <name evidence="8" type="ORF">CYQ11_13725</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50971">
        <property type="protein sequence ID" value="PHQ50971"/>
        <property type="gene ID" value="BLA24_14350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13807">
        <property type="protein sequence ID" value="PPT13807"/>
        <property type="gene ID" value="CYQ11_13725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="203" mass="22842" checksum="248E05974C4A1AA1" modified="2018-01-31" version="1">MTERRLTAVSEFQNPVAGFGVTFKAMFKKRLTEQYPEEKKHTAPRFHGRHQLNRHPDGLEKCVGCELCAWACPADAIYVEGADNTDEERYSPGERYGRVYQINYLRCILCGLCVEACPTRALTMTNEYELADASRESLIYTKEQLLAGLDDRMVDTPHAIYPGMTEQDYYRGLVTGAAPGTVRQVAVSNGEKPQENHEEGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ8</accession>
    <name>A0A2G1XIJ8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">BLA24_14710</name>
        <name evidence="7" type="ORF">CYQ11_13360</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948644.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XIJ8"/>
    <dbReference type="EnsemblBacteria" id="PHQ51030">
        <property type="protein sequence ID" value="PHQ51030"/>
        <property type="gene ID" value="BLA24_14710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13747">
        <property type="protein sequence ID" value="PPT13747"/>
        <property type="gene ID" value="CYQ11_13360"/>
    </dbReference>
    <dbReference type="GeneID" id="58435590"/>
    <dbReference type="GeneID" id="63982123"/>
    <dbReference type="GeneID" id="67399231"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="102" mass="11521" checksum="87AE8768EB157E09" modified="2018-01-31" version="1">MAGQKIRIRLKAYDHEVIDSSAKKIVETVTRTGASVAGPVPLPTEKNVYCVIKSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDSLMRLDLPAGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIS0</accession>
    <name>A0A2G1XIS0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_15360</name>
        <name evidence="5" type="ORF">CYQ11_12715</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51144">
        <property type="protein sequence ID" value="PHQ51144"/>
        <property type="gene ID" value="BLA24_15360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13633">
        <property type="protein sequence ID" value="PPT13633"/>
        <property type="gene ID" value="CYQ11_12715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304885" evidence="3">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="199" mass="19315" checksum="E99DA6338BB0E992" modified="2018-01-31" version="1">MRNARVLAGAAMTITALGLCGAPALAADEFGKLEISPARVQPGETVTVNTTACGAKGHGTADASAVGGPASFELKPGTRKEVAAGEFRVPDSAKPGTYGIGAKCDNGKEATGDVTVGKGSGSGPSPAAGTGSRPAPRPASPSATRSMPAAPPQGGMKTGVGGTSEDSGTTEIVAGATVLGAAVAAGAWFLRRRGGDNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ28</accession>
    <name>A0A2G1XJ28_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppc</name>
        <name evidence="13" type="ORF">BLA24_15895</name>
        <name evidence="14" type="ORF">CYQ11_12180</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51236">
        <property type="protein sequence ID" value="PHQ51236"/>
        <property type="gene ID" value="BLA24_15895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13540">
        <property type="protein sequence ID" value="PPT13540"/>
        <property type="gene ID" value="CYQ11_12180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="907" mass="100883" checksum="6C3A397B77B5B951" modified="2018-01-31" version="1">MSSADNTNAALRADIRRLGDLLGETLVRQEGEELLDLVERVRALTRTDGEAAAELLSTTDPQTAAKLVRAFSTYFHLANITEQVHRGRELRARRDAEGSILARTADQLKEADPEHLRQTVQHLGVRPVFTAHPTEAARRSVLNKLRRIAKLLDAPGTGTGDKRRTDLRLAENIDLLWQTDELRVARPEPTDEARNAIYYLDELHAEAVGDVLEDLAAELDRVGVTLPATTRPLTFGTWIGGDRDGNPNVTPQVTWDVLILQHEHGITDALAVVDELRGALSNSIRNSGATEELLTSLQRDLELLPEISPRYKRLNAEEPYRLKATCVRQKLVNTRERLAQGTPHQDGRDYLGTGELLADLQLVQDSLRAHRGRLIADGRLERAIRTLAAFGLHLATMDVREHADAHHHALGQLFDRLGEESWRYADMPRDYRRKLLAKELRSRRPLAPSPAPLDAAGTKTLGVFGTIREALQKFGPEVVESYIISMCQGADDVFAAAVLAREAGLIDLHAGWAKIGIVPLLETTDELKEADRLLDEMLADPSYRRLVALRGDVQEVMLGYSDSSKFGGITTSQWEIHRAQRRLRDVAHRYGVRLRLFHGRGGTVGRGGGPTHDAILAQPWGTLEGEIKVTEQGEVISDKYLLPALARENLELTVAATLQASALHTSPRQSDEALARWDAAMDTVSDAAHDAYRRLVEDPDLPAYFFASTPVDQLAELHLGSRPSRRPDSGAGLDGLRAIPWVFGWTQSRQIVPGWFGVGSGLKAAREAGLDTVLEEMHEHWHFFQNFLSNVEMTLAKTDLRIAQHYVDTLVPDELKHVFDLIKAEHELTVREVLRITGETELLDASPVLRQTFHIRDAYLDPISYLQVTLLDRQRRAAERGEEPDPLLSRALLLTVNGVAAGLRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ92</accession>
    <name>A0A2G1XJ92_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15995</name>
        <name evidence="3" type="ORF">CYQ11_12080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51251">
        <property type="protein sequence ID" value="PHQ51251"/>
        <property type="gene ID" value="BLA24_15995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13523">
        <property type="protein sequence ID" value="PPT13523"/>
        <property type="gene ID" value="CYQ11_12080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="148"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="328" mass="35137" checksum="66D62432C92A6D09" modified="2018-01-31" version="1">MNDSASGTDPLGRIVLLTTSHRVAPGLLSWPAWQTLRAADRVLCADADHPQLPYLREAGVEVEHTAPAARELVDYCAGGGRTAVVLTSAEGESALTDGLARLAGSGRESMPALELLPGSYDLPGARLLDLVQVMDRIRRACPWSGIRTHEDLAKYGLEEMYELLEAIETGDREALREELGDVLLQVVFHARIAQDDPDEPFSVDDVAGVIVDKLVHRHPHVFGEESAETPEDVRAHWMRTKDAEKRRDSVTEGVPLGQPALALAAKLASRVRSGGLDVPVPAGDGVGYELLALAVRAEAAGVEPETALRAAARTYRDAILAAEAATGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJB2</accession>
    <name>A0A2G1XJB2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">BLA24_16380</name>
        <name evidence="14" type="ORF">CYQ11_11695</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004952403.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51315">
        <property type="protein sequence ID" value="PHQ51315"/>
        <property type="gene ID" value="BLA24_16380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13459">
        <property type="protein sequence ID" value="PPT13459"/>
        <property type="gene ID" value="CYQ11_11695"/>
    </dbReference>
    <dbReference type="GeneID" id="58473910"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="87" mass="9954" checksum="DC2C76E114397567" modified="2018-01-31" version="1">MTELFQQLLVEEADEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJB6</accession>
    <name>A0A2G1XJB6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">BLA24_15860</name>
        <name evidence="11" type="ORF">CYQ11_12215</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51229">
        <property type="protein sequence ID" value="PHQ51229"/>
        <property type="gene ID" value="BLA24_15860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13547">
        <property type="protein sequence ID" value="PPT13547"/>
        <property type="gene ID" value="CYQ11_12215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="34200" checksum="9EE93A10BB2086EF" modified="2018-01-31" version="1">MNGKNCLVTGGAGYVGSVVAAHLLAAGHTVTVLDDLSTGHRDAVPDGARFVQGRVQDAAHHLDGSYDAVLHFAAFSQVGESVTRPEAYWSNNVGGTLDLLAAMRDADVRTLVFSSTAATYGEPATVPIREDAPTAPTNPYGATKLAVDHMIAGECAAHGLAAVSLRYFNVAGAHGRYGERHAPESHLIPLVLQVALGERETISVYGDDYPTPDGTCVRDYLHVADLAEAHLLALDAARPGEHLVCNLGNGSGFSVREVIETVRKVTGHPVPEAVAPRRAGDPAVLVASAERARERLGWRPRRTSLASIVEDAWGFARRNGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJB7</accession>
    <name>A0A2G1XJB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15110</name>
        <name evidence="4" type="ORF">CYQ11_12960</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51348">
        <property type="protein sequence ID" value="PHQ51348"/>
        <property type="gene ID" value="BLA24_15110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13675">
        <property type="protein sequence ID" value="PPT13675"/>
        <property type="gene ID" value="CYQ11_12960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="94"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="396" mass="44766" checksum="F942E3D7C42F5C60" modified="2018-01-31" version="1">MELPRIVSVDDHVIEPAHLFDTWLPAKYRDRGPRPLTEGIGELEYVGGKYRITMDPAGPPADWWIYEDLRFPYKRNIAAVGFDRDQMTLEGITRAEMRPGCWDPVERLKDMDLNHVEASLCFPTFPRFCGQTFSEAHDKEVALACVRAYNDWMVEEWCGDSGGRLVPLCLIPLWDVGLAVAEIRRNAARGVRAVTFSEIPTHLGLPSIHSGYWDPFFAACQESDTVVNMHIGSSSQMPSASPDAPVAVQATLSFNNAMASMADFLFSGVLVRFPRLKLAYSEGQMGWIPYTLERADDVWREHRAWGGVRELIPEPPSTYYYRQIFCCFFRDKHGVASLDAVGRDNATFETDYPHVDSTFPHTKEVALDHVRGLDDETVRKLMRGNAIRMLGLDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD0</accession>
    <name>A0A2G1XJD0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15695</name>
        <name evidence="4" type="ORF">CYQ11_12380</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51364">
        <property type="protein sequence ID" value="PHQ51364"/>
        <property type="gene ID" value="BLA24_15695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16513">
        <property type="protein sequence ID" value="PPT16513"/>
        <property type="gene ID" value="CYQ11_12380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="245" mass="26408" checksum="5E5813F03CF4142E" modified="2018-01-31" version="1">MAELAGEAGITVRTLRFYRERKLIPPPRRDGRIAWYNDHHLARLRTIAALLERGHTLGGIAELFAAFECGRDVGELLGLAGAGITVPWSEETAIRLSPEDLADRFAGEVTPENLTAALDIGYLALDGDEIVHVSRRLLEASTALVRSGVPLAAVLAAGRQVRTHANAMAETFTDLIRDHVPEEAREALRPFAKAVVEAEFTMAMDRRARTQETPDRNSGGSPSQTQPADGAGREGAGRGGPWQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJH1</accession>
    <name>A0A2G1XJH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13750</name>
        <name evidence="4" type="ORF">CYQ11_01445</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51398">
        <property type="protein sequence ID" value="PHQ51398"/>
        <property type="gene ID" value="BLA24_13750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11738">
        <property type="protein sequence ID" value="PPT11738"/>
        <property type="gene ID" value="CYQ11_01445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="21515" checksum="46E9EED350EA123B" modified="2018-01-31" version="1">MSPKQQRGEATADLLLTSALDVYATSGQQGFTVNAVTAASGVSLGSLYHHFGSFDGLAGALYTRCTEQLFDEMIAALHRSRTARSGLRALVQAYLRFTVEHRDAALFLHASAYSGYLAARAEEIRAVKAAKLAVVADWMRARIEKGEIVPLPGPLIEVLVMGPVAEAARRWLSSTYDLDLDQAARLLPDAIWRSLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJJ3</accession>
    <name>A0A2G1XJJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16350</name>
        <name evidence="6" type="ORF">CYQ11_11725</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51309">
        <property type="protein sequence ID" value="PHQ51309"/>
        <property type="gene ID" value="BLA24_16350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13465">
        <property type="protein sequence ID" value="PPT13465"/>
        <property type="gene ID" value="CYQ11_11725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304820" evidence="3">
        <location>
            <begin position="31"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="291"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="486" mass="50269" checksum="DA33F95A3E203BB5" modified="2018-01-31" version="1">MRGNFVFPAVTVCAAALTLPFLATPSGATAPNAPSGAAREVPSRAVPGTTRSLPLGVGGHRLGPDGAGAGLEARRVSPFSLVGIVWDDAAAELRGRAQVRTRAIGTGAWSAWQDVQTHDDDRPDPGSPETRQRGLRGSTAPLWVGPSDGVEVRVAPDKAAGKAAGKPALPSGLHLELVDPGAEPAAGRPLGRHAPATPGPEDDEMAASAANAPLAPLGATEIPALGRPDSARDVAATRPDVVAQAGRPPGDEPGGQGDPEVHDPETSALTDPEESDVYEPALGGRYVGPRPRIVTRAGWGADESLRERGFVYTGSVRAAFVHHTASGNEYSCSQSGSVIRGIYRYHVVSSGWRDIGYNFLVDKCGTIYEGRAGGVAKPVKGAHTLGFNTNSMGIAVLGTFAKNNPSYAAVDAVATLTAWKLGLYDVNPLGTAQLVSGGGNLYKKGTKVRLKVISGHRDGYATECPGDRLYSRLGSARSSAARLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK8</accession>
    <name>A0A2G1XJK8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_15520</name>
        <name evidence="8" type="ORF">CYQ11_12555</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51361">
        <property type="protein sequence ID" value="PHQ51361"/>
        <property type="gene ID" value="BLA24_15520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16516">
        <property type="protein sequence ID" value="PPT16516"/>
        <property type="gene ID" value="CYQ11_12555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="481" mass="50322" checksum="688D1A7013C5865D" modified="2018-01-31" version="1">MTASFMDLVDVTIVNIAMPSIRDDIGASFSTLQWITEGYALAFAAGLITGGRLGDIYGRRRIFLLGMSGFTLASMLCGIAGDPQLLVAARVLQGATAALMVPQVLAIVHATFPAHERGKVFGMFGAVVGLGAVSGPILGALLTQWNLFGLEWRPIFLVNLPVGVAGLLLGRKYISESRAPQALKLDLVGMALATGGVLMLLYPLTQGRELGWPLWGHLCMAGSVLVLAAFVAYERHKSRKDGSPLVELSLFKVKSFAAGIGVELAFGIACGIFFLIWTLYMQIGLGWSPLRAGLTGIPFSIAVSVAAGVSVQKLVPRFGRKVLQAGALAMASGVLLYIWESGHYGKDIAPWQMALPLVVMGLGMGLIVAPLTETVIAEVPREHSGSASGLINTTQQLGNAMGLGLVSVVFFDALDEGRMARGHAAEAFGDAFRNGMWWVAGVLGAVLALMFALPRKAKAGAAAAEGADAEAGTARESAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJR0</accession>
    <name>A0A2G1XJR0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13335</name>
        <name evidence="2" type="ORF">CYQ11_01055</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51488">
        <property type="protein sequence ID" value="PHQ51488"/>
        <property type="gene ID" value="BLA24_13335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11670">
        <property type="protein sequence ID" value="PPT11670"/>
        <property type="gene ID" value="CYQ11_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="20246" checksum="EC21BB433B497BD7" modified="2018-01-31" version="1">MKILLIGAGGTIGSAVHTTLTGRGHEVVTVGRTSGDVRLDMSDPQAVGRLYEQCGQVDAVAVAAGDAVFGPLDALTYDDFSATLRGKALSQVELVRQGTRHVAPRGSFTLVTGVLTHEPVPGAAAAAAANGAVEAFVRAAAIELAPQRVNAVSPGLVAESADAYGQVFPGVEPVPAARVATAYVRAIEGAATGQVLRVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK66</accession>
    <name>A0A2G1XK66_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_12780</name>
        <name evidence="7" type="ORF">CYQ11_17135</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51571">
        <property type="protein sequence ID" value="PHQ51571"/>
        <property type="gene ID" value="BLA24_12780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14363">
        <property type="protein sequence ID" value="PPT14363"/>
        <property type="gene ID" value="CYQ11_17135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304829" evidence="4">
        <location>
            <begin position="46"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="263"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="40239" checksum="EFE6567A94341712" modified="2018-01-31" version="1">MRTRASERGPREGRGGKLRLALATALVCAVSVGAVVLGSPGVAHADPTPPRNPAPGPSSPPSPGPSRDLEGVHREVETLYRKAEAATDAYNAASEQQRLQEKSIAEIAGQVRTAQERLDRLRGQAGALARAQYRNGGLPPHTELFFSGAPDTFLNGVTLARKGEQATHDLLAALTATRAELDGYAKAADERWKTLAGDRRKKEDAKKEIEAKLEAAKKLEAQLEEKERERLRQLEEEWARQAQASWLATDAAKGLAGRGSAATGDAGRAVDFATAQLGKNYVWGAEGPDTFDCSGLTLKAWAAAGHAIPRTSQEQWRQLPKVDVKDMRPGDLVIYFSDASHVGMYVGGGSIVHAPRPGRQVTVAGAGSMPILGVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKC7</accession>
    <name>A0A2G1XKC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11410</name>
        <name evidence="2" type="ORF">CYQ11_02645</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51693">
        <property type="protein sequence ID" value="PHQ51693"/>
        <property type="gene ID" value="BLA24_11410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11942">
        <property type="protein sequence ID" value="PPT11942"/>
        <property type="gene ID" value="CYQ11_02645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13240" checksum="256E9C921ABD56A4" modified="2018-01-31" version="1">MTGIDGCLAEAMTVPGARGASLVDWSSGLALGAAGHGPDSDHETAAAGAAELARLAFENGAFTGATPDSGPVEDLVVTARGSYHLMRFVETSFDSSVFLYLWLDRTEANLAVALFRLKDLTARLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKX2</accession>
    <name>A0A2G1XKX2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_11105</name>
        <name evidence="13" type="ORF">CYQ11_16820</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000133">
        <property type="protein sequence ID" value="PHQ51877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51877">
        <property type="protein sequence ID" value="PHQ51877"/>
        <property type="gene ID" value="BLA24_11105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14306">
        <property type="protein sequence ID" value="PPT14306"/>
        <property type="gene ID" value="CYQ11_16820"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="81"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="171"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ51877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT14306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="341" mass="35970" checksum="BB756D313FA1C53B" modified="2018-01-31" version="1">MSTNDDRPLHQIGRSGQETEAQTAAGGCGDACGCAGGEYDADLLECGLDPELTRLLVAAGLDPLQIEDLAHLAIEEDLDGGKDITTFATVAEDAVSTGDFTAREAGTIAGLRVAEAILSVVCTDEFEVERHVEDGDRVEAGQPLLTVRTLTRDLLTAERSMLNILCHLSGIATATRAWADALEGTGAAVRDTRKTTVGLRALEKYAVRCGGGVNHRMSLSDAALVKDNHVIAAGGIAEAFTAVRREFPDVPIEVEVDRIDQIPPVLDAGADLVMLDNFTPGQTREAVELVAGRARLESSGRLTLANAREYAATGVDYLAVGALTHSSPILDIGLDLREEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL51</accession>
    <name>A0A2G1XL51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10885</name>
        <name evidence="4" type="ORF">CYQ11_00665</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51946">
        <property type="protein sequence ID" value="PHQ51946"/>
        <property type="gene ID" value="BLA24_10885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11610">
        <property type="protein sequence ID" value="PPT11610"/>
        <property type="gene ID" value="CYQ11_00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="102"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="302" mass="32922" checksum="24E6C15442AF3A1A" modified="2018-01-31" version="1">MRLPTRSPRRLTPESDTPKEAPKVTQEPQPDQRPIPPAVQKAYGAADLGANPLFAGGFINFGHWQAIDTTAGLSQEDRVRSQQDMYRHVLEALPPAGGSRALEVGSGTGVGSALALEEYGFAHLTGMDIHPQQLIRAQECNSRILKDRPDHLDFVQGAAEDMPFADGEFDYLYSVEAAQHFSDLDAFGRETARVLRPGGHAVVASFFTTDDAPGRAKRLAGLLDCYANGLDIAHPVTHVVDALARAGLKGTRAVSIGPSVWQGWDRWIAHVSEPDGWPRNFLRVHEEGVLDYYVVTATRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL99</accession>
    <name>A0A2G1XL99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10020</name>
        <name evidence="3" type="ORF">CYQ11_02490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000105">
        <property type="protein sequence ID" value="PHQ52018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52018">
        <property type="protein sequence ID" value="PHQ52018"/>
        <property type="gene ID" value="BLA24_10020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11916">
        <property type="protein sequence ID" value="PPT11916"/>
        <property type="gene ID" value="CYQ11_02490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="345" mass="35391" checksum="B1C0CDBC58AA505F" modified="2018-01-31" version="1">MKALVARLDSFGDVLLAGPAVRAVAARARHTTLLCGPRGAPAARMLPGVDEVIVWDAPWVGLDPPAVDRGDVGRLVERVARRAPDVAVVLTSFHQSPLPTALLLRMAGAGRLAADCEDYPGSLLDVRHRRAPHRHEVLAALDVAAAAGFPLPEGDDGRLAVRRPPAPDALVGGAGYVVVHPGAAVPARRWGRERCAAAVRLLVRAGYRVVVTGGRGERGLTAAVAAGGALDLGGRTGPAELAGVLSRAAAVVVGNTGPAHLAAAVGTPVVSLFAPVVPAERWAPYGVPHVLLGDERAPCASSRARVCPVAGHPCLSGVSPEDVLAAVEKLTGRTPGLDPCLERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLF8</accession>
    <name>A0A2G1XLF8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ORF">BLA24_09095</name>
        <name evidence="7" type="ORF">CYQ11_27705</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52072">
        <property type="protein sequence ID" value="PHQ52072"/>
        <property type="gene ID" value="BLA24_09095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16152">
        <property type="protein sequence ID" value="PPT16152"/>
        <property type="gene ID" value="CYQ11_27705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="23465" checksum="908DE065C9FE71CB" modified="2018-01-31" version="1">MSVMVVTGTGTEVGKTVVTAAVAAAALAAGRTVAVLKPAQTGVAPGEPGDVAEVRRLAGPVTGAELARFPEPLAPATAARRAGLAPVGPEEIRRAAAELAASHDLVLVEGAGGLLVRLDEAGSTLADVAGLLDAPVLVVVQAGLGTLNTTALTAEALRARGLRCAGVVIGSWPAEPDLAMRCNLTDLPREAGAPLLGAVPEGAATLPPEDFRAVAAGWLAPELDGTWAGAVPPGSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLW5</accession>
    <name>A0A2G1XLW5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_08500</name>
        <name evidence="5" type="ORF">CYQ11_03755</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52200">
        <property type="protein sequence ID" value="PHQ52200"/>
        <property type="gene ID" value="BLA24_08500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12133">
        <property type="protein sequence ID" value="PPT12133"/>
        <property type="gene ID" value="CYQ11_03755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="29"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="264" mass="28681" checksum="C03521D37637B45D" modified="2018-01-31" version="1">MCKNQGDVSADRWFRAVTQRYQNPRVRLVCFPHAGGTASYFRGWGRLVPYGVEVLAVRYPGREDRLLEPLAQSMEELADGVLQAVPGLFDVPVAFFGHSMGASVAYEVALRLRAGAGPSPTALFLSGRSGPGHDRTRGLAAAGDAELIDDVVAMGGTDAQAFADPELRELVLPVIRADYALVERYRARIPDPELDVPVVAYHGDADPALDDDSVAAWQAVTRGPFDVRRFTGGHFYLADHARDLVEDVVARLESAPKEQAARPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM09</accession>
    <name>A0A2G1XM09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_08565</name>
        <name evidence="6" type="ORF">CYQ11_03820</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52211">
        <property type="protein sequence ID" value="PHQ52211"/>
        <property type="gene ID" value="BLA24_08565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12144">
        <property type="protein sequence ID" value="PPT12144"/>
        <property type="gene ID" value="CYQ11_03820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="29764" checksum="751BCE3ED5F05B0A" modified="2018-01-31" version="1">MSDNQNLLAEQRRALILDEVRRRGGVRVNELTRRLNVSDMTVRRDLDALARQGVVEKVHGGAVPVAEATAHEPGFEAKAALELSAKEDIARAAARMAARGSAIALAGGTTAYALAQALVDIPDLTVVTNSVRAADVFHTAQRTMTASGPAARPGAATVVLTGGVRTPSDTLVGPVADAAIRSLHFDVLFIGVHGISVEAGLSTPNLAEAETNRHFVRSARRVVVLADHTKWGTVGLSSFAALDEVDALVTDAGLPDRARAEIAERLPQLVVAGPGGEGADIPPGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XME9</accession>
    <name>A0A2G1XME9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_08030</name>
        <name evidence="8" type="ORF">CYQ11_00470</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52417">
        <property type="protein sequence ID" value="PHQ52417"/>
        <property type="gene ID" value="BLA24_08030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16261">
        <property type="protein sequence ID" value="PPT16261"/>
        <property type="gene ID" value="CYQ11_00470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="464" mass="47931" checksum="D9BBC6B55C6AE648" modified="2018-01-31" version="1">MLAIVLAGELMAVLDASVVDTALPSIQADTSVSAAGLQWIHAAYGLALALGLITGGRLGDLYGRKRTFLLGAGAFTAASLLCSLAAGPAALIAARAVQGAGAAVMVPQVLATVHVAFDGSDRAKAFGLYGTVMSVGSVAGPVLGGVLIQADLFGLSWRSLFLINVPLGIATVLLGHRYLTESHNRQALRLDLLGMVLSALGLLLIAYPLSAGGSHHWPWWTFTAMAAGVAVLVGLVFQQRNKTCKDGSSLVVLSLFSGRPFSGGLTAQLVLGLLSGLFFMCWTLFMQQGLGLSPLRAAIGFLLLTLAEIGGAWLAMTAVARHQRRVPQVGALLAALALTVFHLLVTTYGTGLSMTAMALPVLALGLGLGMIGAPLTDLTLGRVGEAHAGSASGLFNTATHLGIALGVVLTGVVFFSHDQTAAARGTDVADAFTATLPYVIGGLLTMWALMFFLPRPASRRTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMH3</accession>
    <name>A0A2G1XMH3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06610</name>
        <name evidence="4" type="ORF">CYQ11_26760</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52452">
        <property type="protein sequence ID" value="PHQ52452"/>
        <property type="gene ID" value="BLA24_06610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15984">
        <property type="protein sequence ID" value="PPT15984"/>
        <property type="gene ID" value="CYQ11_26760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="476"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="686" mass="73133" checksum="A55DEB968FF49469" modified="2018-01-31" version="1">MGTSDAFRPDPARAGVPVYEPGGLLDVLNVAAAVLDQDGRIVLWSPQAEELFGWTAAEALGEYAARLLVAEENHDEVLRLFAKVMGDAGTWAGSFPALHKDGTTRLLEFRNMRLEDRSGGVYALGMATDQQVLRGLERDLALSLRLVAQSPIGLAVLDTGLRYVMVNPALERIHGLPARSHIGRHVREAIPFTDVEVVESAMRQVLATGTPLVDQFIVGPTADPEAGERARLVSYYRLEDPAGRALGVATSVVDVTDRHRSTTEARRRLALIADASVLIGTTLDLDQTARELADVVVPGLADVAAVDVLDTALRPSSAPSEGQAVFRALAVAASDATEAVRAADPPGEIAKYDADRLVSQCVRTGRPVRLAHVTPGDLPRIARDEAAAAMLGRAGLHSYMAVPLIARGEVLGALDLKRTRNREPFGEDDLVLAGELAARAAVCIDNARWYQRERATAVTLQRDLLPQRPQNLVGLEVAYRYQPAGSASQVGGDWFDVIPQDGTQSALVVGDVMGSGINAAAAMGQLRTAARTLSGLGLDPARVLHHLDRTASGLDQTIATCLYAVYDPDSERCCLANAGHLPPVLVRPGKRPTLLDLPTGAPLGVGGVPFESVSVVLAPGDQLVLYTDGLVETRDEAIDARLEVLIDLLDGPRGDLEATCDLLLGELREDNDQDDVALLIARVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMU6</accession>
    <name>A0A2G1XMU6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07345</name>
        <name evidence="3" type="ORF">CYQ11_27500</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52575">
        <property type="protein sequence ID" value="PHQ52575"/>
        <property type="gene ID" value="BLA24_07345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16113">
        <property type="protein sequence ID" value="PPT16113"/>
        <property type="gene ID" value="CYQ11_27500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="317" mass="31919" checksum="EE65B6D511F112D2" modified="2018-01-31" version="1">MSSPTGPVSGLPVRMPRPRQPGRHRRPEPAAAPAGAPPLVLAVPGTPDVATRRLAEETLSIARSELPGLDARIGYVDVLPDTDGAEGYPALDAVLGYAAAQRAAREAEARAAEDADGAADVWAQAPDAVVVPLLAGPDSSVLRRIRQSVMNSGAAAELTDALGPHPLLAEALHVRLSEAGLARADRARLFTVATAADGIVLATVGGEEAVQAAGISGMLLSARLAVPVLAAALDAEGAVARAAEQLRGSGSRNLALAPCFVGPEVDETLTAMAAKEAGCAAAEPLGAYPAIGKLVLAHYASALGISVQPAPQGASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN13</accession>
    <name>A0A2G1XN13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06390</name>
        <name evidence="4" type="ORF">BLA24_06405</name>
        <name evidence="2" type="ORF">BLA24_18690</name>
        <name evidence="5" type="ORF">CYQ11_14590</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000079">
        <property type="protein sequence ID" value="PHQ52636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000079">
        <property type="protein sequence ID" value="PHQ52637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50912">
        <property type="protein sequence ID" value="PHQ50912"/>
        <property type="gene ID" value="BLA24_18690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52636">
        <property type="protein sequence ID" value="PHQ52636"/>
        <property type="gene ID" value="BLA24_06390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52637">
        <property type="protein sequence ID" value="PHQ52637"/>
        <property type="gene ID" value="BLA24_06405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16563">
        <property type="protein sequence ID" value="PPT16563"/>
        <property type="gene ID" value="CYQ11_14590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="196"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="300" mass="32377" checksum="A681587086F5EF3B" modified="2018-01-31" version="1">MVKKRHDAPDGEGGEIVELAYDAPPGTPAGVEVLTLAELRERAPEGLLPRPQRLDFHQIVAVDSGSAVHTVDFTAHTLDAGSVLWVRPGQVQQFGDVAAVEGTVVLVQPGFLPPGTAVSEVADEPFRPVLWRPVGDDREAVFCAVRHLATDFRTGSRLPPGIHADVLRHLLSVLVLRLAHGTAAASGVPAPAEAFVRFRAAVERGFATRHRVADYARELGYAPRTLTRATLAAAGVGAKEFIDRRVMLEARRLLAHSDLPAARIAGQLGFDDAANFSKFFHHRAGDSPGAFRRRHRYGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP34</accession>
    <name>A0A2G1XP34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05160</name>
        <name evidence="5" type="ORF">CYQ11_28370</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52986">
        <property type="protein sequence ID" value="PHQ52986"/>
        <property type="gene ID" value="BLA24_05160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11502">
        <property type="protein sequence ID" value="PPT11502"/>
        <property type="gene ID" value="CYQ11_28370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="139"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="31688" checksum="950A58FE2CB0CECC" modified="2018-01-31" version="1">MAATAILWGSAFPAIRVGLEGYSPTAIAVLRLAFALLFLVPCLLTGRISRLRRGDALRMAGFGVTGMTAYQLLLYAGERHVEGGTAAMLVATSPVFATALGMLVLRERPGAWGIAGLLVALGGALVVATAGGEGGGSRSGMAMIVAAAAAQATSFILQKPLLRRYSGMDCIFYGSLFGLLPLLVFAPQAAGQALAAGWQQSAAVVWLGLACTVLAFCTWSRVLNAAPASTSSLVLYAVPVAALALDAVLLGAVPAPTACLGGLIVLAGVGVAAVRRAPRPPAPSEPVARGGPVSREETARHEETGVRSPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPC9</accession>
    <name>A0A2G1XPC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_03425</name>
        <name evidence="5" type="ORF">BLA24_17230</name>
        <name evidence="7" type="ORF">CYQ11_16045</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000042">
        <property type="protein sequence ID" value="PHQ53105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50559">
        <property type="protein sequence ID" value="PHQ50559"/>
        <property type="gene ID" value="BLA24_17230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53105">
        <property type="protein sequence ID" value="PHQ53105"/>
        <property type="gene ID" value="BLA24_03425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14187">
        <property type="protein sequence ID" value="PPT14187"/>
        <property type="gene ID" value="CYQ11_16045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="242"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="338" mass="37348" checksum="99D15155891A7027" modified="2018-01-31" version="1">MNESCPENDRHESVAVAKFLLASAAATGADPHGIVREASLSSDALTEADARVPSPAMFALWELTDRVMEVKDTALTMAGQYRLGALDLLDYLATSAPTLGEAMRLTLRYLPFISTNCRLELVEENDRETTYAFSHFQDGGPATDLSERFSLAVLCIRANEATRQLVRPVHVGFAQEAPRRHADLAELFSARQRLDFGQATGSFTFRTSDLRLPIATADPALHAILRRYADTLPLPTPETWESRFRRLLTESLADGTVGLDAMARRLAVSPRTLQRRLADAGTTWRAELDAARRTRAEKAARQGGTPVSVLADRLGYSDARSLRRARRRWEDVPATPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPH1</accession>
    <name>A0A2G1XPH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_01975</name>
        <name evidence="2" type="ORF">CYQ11_04335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53138">
        <property type="protein sequence ID" value="PHQ53138"/>
        <property type="gene ID" value="BLA24_01975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12228">
        <property type="protein sequence ID" value="PPT12228"/>
        <property type="gene ID" value="CYQ11_04335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14507" checksum="42983905FF0CC9FB" modified="2018-01-31" version="1">MTGDRGQAAHWYDDAAGPVVRPYAMTRGRTRSPAEDRLDLIALVVAEELLVAHPGGAHAIADHTLSPEHLDIADLARQGPQSVAELAAGLDLPVGVVRVLVGDLMDGGYVRVSRPVPPAELPDEGILREVIDGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPJ0</accession>
    <name>A0A2G1XPJ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02075</name>
        <name evidence="2" type="ORF">CYQ11_04440</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53154">
        <property type="protein sequence ID" value="PHQ53154"/>
        <property type="gene ID" value="BLA24_02075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12244">
        <property type="protein sequence ID" value="PPT12244"/>
        <property type="gene ID" value="CYQ11_04440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="10058" checksum="FA9FCBF0AACA0024" modified="2018-01-31" version="1">MGGAAVTAPARASWSKAVRAQALRLREQAGRLREAAAAVTLPGAEGAAVRRRITGQADRAETAAAALEHAADDLLAHEAVLAALARRRREGGAARNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPK2</accession>
    <name>A0A2G1XPK2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02120</name>
        <name evidence="4" type="ORF">CYQ11_04485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53162">
        <property type="protein sequence ID" value="PHQ53162"/>
        <property type="gene ID" value="BLA24_02120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12253">
        <property type="protein sequence ID" value="PPT12253"/>
        <property type="gene ID" value="CYQ11_04485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="222" mass="22951" checksum="10D844C8019D0096" modified="2018-01-31" version="1">MSASGGSLLARRLVQLYGGLVLYGMSAALQVRAGLGLAPWDVLNQGISRHTGLSIGTASIAVGVLVLLLWIPLRQRPGLGTVSNVLVIGLALDATLSLTPRPESLWARIPLLLVAVVLCGLATGLYIAPRFGPGPRDGLMTGLHKRTGRSVRFVRTCIEVAVLATGFALGGSLGVGTVLFAVAIGPLAQFFLKVFALPETGGPSEAEPISPILPAHDVPDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPK9</accession>
    <name>A0A2G1XPK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02225</name>
        <name evidence="6" type="ORF">CYQ11_04585</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53178">
        <property type="protein sequence ID" value="PHQ53178"/>
        <property type="gene ID" value="BLA24_02225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12270">
        <property type="protein sequence ID" value="PPT12270"/>
        <property type="gene ID" value="CYQ11_04585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="27982" checksum="2174E548ABD1FAA5" modified="2018-01-31" version="1">MRIAVEDLDVALSGRTVVSGVRIVAEDGEIAGLVGPNGSGKSTVLRTVYRHLRPHAGRVLVGGTDIRALSPAESARQVAALPQERGSDFELSVREVVAMGRTPYKRAFAGEDRGDAGLVESALERVGMVGAGRRRFSALSGGERQRVLLARALAQDPRVLVLDEPTNHLDVRHQVELLALLREQRRTTLLALHDLNAAASVCDRLHVLHGGAVVASGTPREVLTADLLAEVFGVRAAVVEHPLTGDPLIAFDHRAPAALTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPQ0</accession>
    <name>A0A2G1XPQ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02465</name>
        <name evidence="2" type="ORF">CYQ11_04830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53218">
        <property type="protein sequence ID" value="PHQ53218"/>
        <property type="gene ID" value="BLA24_02465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12309">
        <property type="protein sequence ID" value="PPT12309"/>
        <property type="gene ID" value="CYQ11_04830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="456" mass="49782" checksum="DF774F597AF374EF" modified="2018-01-31" version="1">MTRSGGTPPAAHDAWRAAVPEPTGELAADAAALDAYTRHGRDLLAALPAKADRDPEQLHTGELVHEAARLARSRFLQPHTEAVYRQLTDDGTAHPRLGELAYAAAEAFPGLVPSRKETEAEEGLVQAHKEGLEIDQGIFFRALLGTPSTGRHLIDSMLRPTPRAEELLPGFQATGEVDLGTVHLERRGPAAHLTIHNQLFLNAEDNELIADMETAVDLALLDDEVTVGVLRGAPMTHPRYLGRRVFSAGINLTYLHEGRISYTDFLLGRELGYISKFVRGLKVPDGSRETRTVEKPWLAAVDTFAIGGGMQLLLAVDRVVAGADAYFSLPAAQEGIVPGVANLRLARLMGGRAARRVILGGRKVWAHEPEARLLCDEVVDPREMDAAVDHGVDMLDSPAVVANRRMLNLAEEPVDSFRAYMAEFAMAQALRLHSKDVLHKVHRFSDRRSSHRAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPS9</accession>
    <name>A0A2G1XPS9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02600</name>
        <name evidence="6" type="ORF">CYQ11_04895</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53223">
        <property type="protein sequence ID" value="PHQ53223"/>
        <property type="gene ID" value="BLA24_02600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12315">
        <property type="protein sequence ID" value="PPT12315"/>
        <property type="gene ID" value="CYQ11_04895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="33223" checksum="1583E13A7AD39BD3" modified="2018-01-31" version="1">MNELMIETLDVGKTYGTVRALDGVNLTVPRGTVLGLLGHNGAGKTTLVNILATLQPPSTGTARVAGFDVVGAPVEVRRRIGLTGQYASVDEQMTGLDNLVLIARLLGAHPRAARTRAGELLERFELTAAAKRPVRGYSGGMRRRLDLAASVVNSPAVLFLDEPTTGLDPGSRITLWNIVGEMVAQGSTVVLTTQYLDEADRMADAITVLSEGAVVASGTPAELKDRVGRRAVTVTLASPEDLPRAARALEAAGLRPSYDETRGKLTTPVDSSRQVADVVRALDAVHVEAAELAMTEPTLDDVYLTLARKAPALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPT7</accession>
    <name>A0A2G1XPT7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="13" type="ORF">BLA24_02710</name>
        <name evidence="14" type="ORF">CYQ11_05005</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53242">
        <property type="protein sequence ID" value="PHQ53242"/>
        <property type="gene ID" value="BLA24_02710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12335">
        <property type="protein sequence ID" value="PPT12335"/>
        <property type="gene ID" value="CYQ11_05005"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="50"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="374" mass="39985" checksum="330686B016BF728D" modified="2018-01-31" version="1">MYRLFFDLIFKRMDPEKAHHLAFAWIRGVARVPVLRTFVAAVLAPRHKALRIEALGLRMHGPFGLAAGFDKNAAAVDGMTMLGFDHVEIGTVTAQPQPGNPKKRLFRLVADRALVNRMGFNNDGSAAVAQRLAARKEVFRTTVGVNIGKTKVVPEEEAVADYVASTERLAAHADYLVVNVSSPNTPGLRNLQATEALRPLLAAVREAADRTVTDRRVPLLVKIAPDLADEDVDAVADLAVELGLDGVIATNTTIAREGLGLKTPQRTVEAIGAGGLSGAPLKARSLEVLSRLYARVGDRITLVGVGGVESADDVWERILAGATLVQGYSAFVYEGPFWCRRIHDGLAERLAASPYATLAEAVGAAARETSGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPY7</accession>
    <name>A0A2G1XPY7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">BLA24_02755</name>
        <name evidence="12" type="ORF">CYQ11_05050</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53251">
        <property type="protein sequence ID" value="PHQ53251"/>
        <property type="gene ID" value="BLA24_02755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12344">
        <property type="protein sequence ID" value="PPT12344"/>
        <property type="gene ID" value="CYQ11_05050"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="20628" checksum="283A4CE620420B3F" modified="2018-01-31" version="1">MASTNDLKNGMVLKLEGGQLWSVVEFQHVKPGKGPAFVRTKLKNVLSGKVVDKTFNAGVKVETANVDKRGMQFSYMDGDYFVFMDMDTYDQLHIDRKTVGDAANFLLEGFEAVVAQNEGSVLYVELPAAVELTVKHTDPGVQGDRSTGGTKPATLETDYEIQVPLFITTGEKIKVDTRSGEYLGRVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQD0</accession>
    <name>A0A2G1XQD0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_01365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000020">
        <property type="protein sequence ID" value="PHQ53401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53401">
        <property type="protein sequence ID" value="PHQ53401"/>
        <property type="gene ID" value="BLA24_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="4">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="597" mass="62991" checksum="850E7161F4330FB1" modified="2018-01-31" version="1">MIDAKHRNTALLVAGCFFMENLDGTIVSTAAPRMGASLDVAPTAIGLVVTAYLVTLAVLIPLSGWLTARFGTRRVFLTAIAVFTLSSLGCALSTSLGELVALRIVQGAGGAMMVPSAGDAGPTEGHPRMPRRSAPGPALAPRARTSAGTSSPRLVPARSPGGQGEHGDGGEEDAARAEAGGQPAAERYEDGEGHQIGGDDEADRGGGDVQGRAHAGRRRRHDGAVQVLHEEAARYQERGVAVLGVDHRSPRCSRSRSSSGRASSDHKFRIAKAELTLTQLIARGTPMHLPDMNLLPALDALLREGSVTGAAARMSVSASAMSRTLGRLRRVLGDPLLVPAGRGLTLTPRALELRPRVEAALVGALAALQPVQPVDIASVERRFTLRTNDGLAVVLGPALAERVAMEAPGIQLRWLPEGDEDPADLRGAIDLDIGHLPDLPHDVRSRPLARHRHVAVCRAGAPHADEPLTVERFAALPHITVTRRGRFHSVVDERLAELGLRRRVLATVPTHITACFLALRSDVLALLAAPVAARAAEAMPLVVREIPLPLPSIATGMAWHVRVDADPAHRWLRDAVAQAESPGPEDTRPAPEAAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQG2</accession>
    <name>A0A2G1XQG2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_00580</name>
        <name evidence="5" type="ORF">CYQ11_07590</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53462">
        <property type="protein sequence ID" value="PHQ53462"/>
        <property type="gene ID" value="BLA24_00580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12767">
        <property type="protein sequence ID" value="PPT12767"/>
        <property type="gene ID" value="CYQ11_07590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="88"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="278" mass="29992" checksum="27A341A2763CFD80" modified="2018-01-31" version="1">MSKRNNWEHKQSARERLRAERDRQAKKEKTRRQLLVGGAVVAVLAVVGGIAVAATQLGGDDATDASWKAAKDKTLVKPAHTGGDKGLEVVVGKQDAKHTLEIYQDMRCPVCSVFEQNVGDTVDKDVKDGKYKVAYHIGTFLDRNPAIKGNGSKNALSALGAALNVGPDAFAAYNKALYAKANHPDETKDTFAKDDVLLKIAQQVPALKDNADFEKNVKDGTFDKWALEMSDAFDDAKDVTGTPTIKLDGQKLTVDTPNGKGAPMVAEQFNTAVGQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9B2</accession>
    <name>A0A2G1X9B2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">BLA24_30355</name>
        <name evidence="11" type="ORF">CYQ11_23450</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47817">
        <property type="protein sequence ID" value="PHQ47817"/>
        <property type="gene ID" value="BLA24_30355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15442">
        <property type="protein sequence ID" value="PPT15442"/>
        <property type="gene ID" value="CYQ11_23450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ47817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="31090" checksum="EE147BFDEDB09793" modified="2018-01-31" version="1">MVSTAQIAFLKGHGTENDFVIIPDHDGRLELSPAAVAQLCDRRAGLGADGVLRVVRSAAHPEARAMACEAEWFMDYRNSDGSIAEMCGNGVRVFARYLQRAGLAEEGDLAIATRAGVRRAHIAKAGPDGEPGGVTVAMGRAALPEGDVTVTVGERSWPARNVNMGNPHAVSFVDDLADAGNLYTAPGVSPAAAYPDGVNVEFVVDRGPRHVALRVHERGSGETRSCGTGACAVMVAAARRDGADPAVLGHPVTYTVDVPGGRLVISESPDGTVEMTGPAVIVAEGVLDASWAGIEPAAHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9C3</accession>
    <name>A0A2G1X9C3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_30395</name>
        <name evidence="6" type="ORF">CYQ11_23490</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47825">
        <property type="protein sequence ID" value="PHQ47825"/>
        <property type="gene ID" value="BLA24_30395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15450">
        <property type="protein sequence ID" value="PPT15450"/>
        <property type="gene ID" value="CYQ11_23490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ47825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="659" mass="70486" checksum="A17D473F1896F1FE" modified="2018-01-31" version="1">MTATSSPSLTDLLHAAVTAVGGTERPGQVAMAEAVAAAIDDGSHLLVQAGTGTGKSLGYLVPALAHGERVVVATATLALQRQLVERDLPRTVDALHPQLRRRPEFAMLKGRSNYLCLHRLHEGVPQEEEEGLFDPFEAAAPSSKLGKDLLRLRDWSDETETGDRDDLTPGVSDRAWAQVSVTSRECLGASKCAYGAECFAEAARERAKLADVVVTNHALLAIDAIEGAPVLPGHEVLIVDEAHELVSRVTGVATGELTPGQVNRAVRRAAKLVDEKAADALQTAAESFERLMELALPGRLEKIPEDLGYCLMTLRDAARTVISALGNTRDKSVQDEDAVRKQALASVENIHAVAERIVEGSEYDVVWYERHDRFGASLRVAPLSVSGLLREKLFNERSVVLTSATLKLGGDFNGVGASLGLAPEGVAGDDVPQWKGVDVGSPFDYPKQGILYVAQHLAQPGREGTRSDMLAELAELVEAAGGRTLGLFSSMRAAQAAAEELRERLDVPILLQGEETLGELIRTFAADARTCLFGTLSLWQGVDVPGPSCQLVVMDRVPFPRPDDPLMSARQRAVEEGGGNGFMAVAATHAALLMAQGAGRLVRASGDRGVVAVLDPRLAKARYGSFLRASMPDFWYTTDRNQVRRSLAAIDGAAKADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9H6</accession>
    <name>A0A2G1X9H6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="6" type="ORF">BLA24_30680</name>
        <name evidence="7" type="ORF">CYQ11_23775</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47875">
        <property type="protein sequence ID" value="PHQ47875"/>
        <property type="gene ID" value="BLA24_30680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15500">
        <property type="protein sequence ID" value="PPT15500"/>
        <property type="gene ID" value="CYQ11_23775"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="166" mass="17520" checksum="C9A22C32D7344CC6" modified="2018-01-31" version="1">MSRQPVDVLIRRVDPEVPLPSYGHPGDAGCDLVTTEAAELAPGERMVLPTGISIALPDGYAAFVHPRSGLAARCGVSMVNAPGTIDAGYRGEIKVIVVNLDPRESVRFERFDRVAQLVVQQVERVRFHEVAELPGSARAEGGFGSTGGHAAVGNGFASVACDREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9I6</accession>
    <name>A0A2G1X9I6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_30365</name>
        <name evidence="14" type="ORF">CYQ11_23460</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47819">
        <property type="protein sequence ID" value="PHQ47819"/>
        <property type="gene ID" value="BLA24_30365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15444">
        <property type="protein sequence ID" value="PPT15444"/>
        <property type="gene ID" value="CYQ11_23460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758815" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="41"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="279"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ47819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="491" mass="54093" checksum="8DBB555DDCFB732F" modified="2018-01-31" version="1">MPYSLRERSPRRRRFPRRRAALVVAAAALVVGAAAPPAPAPLGIGDRLFPSLGNPGYDVASYDISFDYRANDEPLDAVTRLVARSTKPLERFNLDFTHGTVASVDVDGRTAEFTSAGEDLVVTPQRKVPAGTTFTVAVHHTSDPREAAPGGWVPTADGLVMANQADAGHRVFPGSDHPSDKALFTFRVTAPKELTVVANGRPAGRRTEGAKTTWVYRTLHPMATELAQVAIGRFAVPERTGPRGLQVRDVVPAEDQKALEAWTAKTPEHLAWMEKKVGPFPFENYGVLMAQASTGFELETQTLSLFERDLFTKPAFPAWYLESIMVHELAHQWFGDSVSPRLWSDVWLNEGHATWYEALYAEEKAGKKLEDRMHAAYEQSDQWRADGGPPAAPKGPVPGKRISIFRPVVYDGGALVLYALRQRIGAPAFERLERQWVSRHRDSTAGTADFVSLAGEVSGRDQSAFLRPWLYGERTPAMPGHPDWKAARKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9M2</accession>
    <name>A0A2G1X9M2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30985</name>
        <name evidence="3" type="ORF">CYQ11_24085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47927">
        <property type="protein sequence ID" value="PHQ47927"/>
        <property type="gene ID" value="BLA24_30985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15552">
        <property type="protein sequence ID" value="PPT15552"/>
        <property type="gene ID" value="CYQ11_24085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="373" mass="40657" checksum="5EE1DA4FA34524B3" modified="2018-01-31" version="1">MEIQGNCSDQFSAVREAFANSLQSGADVGASVAVYLDGELVVDLWGGYADQARTRPWQRDTITNVWSTTKTMTALCALVLTDRNELDLSAPVAKYWPEFGTAGKEHIEIRHLLSHTAGLPDWDQPMTLDDLCDWEKATTLLARQSPRWEPGTTSGYHRFTHGFLIGEVIRRICQESIGTFFADQIAGPLDADFHIGLAAKHDHRVSEVIPAPGPAPTPNPQVTVPVGAYVTAQDTRSTQWRRAEIPAADGYGNARSVAAVQSVLSTGGLTPSARLLSETTCRTVFNEQSHDIDLVLGIPVRFGMGYALNASDSPVSTSNVHTCFWGGRGGSLVVNDLDARMTFTYVMNQMTYLGLTDPRSQKLLQAVYQALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAB0</accession>
    <name>A0A2G1XAB0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32615</name>
        <name evidence="3" type="ORF">CYQ11_25665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48168">
        <property type="protein sequence ID" value="PHQ48168"/>
        <property type="gene ID" value="BLA24_32615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15794">
        <property type="protein sequence ID" value="PPT15794"/>
        <property type="gene ID" value="CYQ11_25665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001111">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="210" mass="22487" checksum="BF19706EE0054BF8" modified="2018-01-31" version="1">MALPAIAPYPMPTGADLPANKVAWTVDPARAVLLVHDLQNYFLDAFTAHASPVTELLANVGRLKKDCARLGVPVVYSAQPGGQTAAERGLQQDFWGPGLPDDARAKAIAEPVAPGADDTVLTKWKYSAFVRTDLAERMAAQGRDQLVIVGVYAHIGVMMSACDAWMRDIQPFLVADAVADFSAEDHAMALRWAAAKCAVVTTTDRVLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC1</accession>
    <name>A0A2G1XAC1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_32575</name>
        <name evidence="11" type="ORF">CYQ11_25625</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48162">
        <property type="protein sequence ID" value="PHQ48162"/>
        <property type="gene ID" value="BLA24_32575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15788">
        <property type="protein sequence ID" value="PPT15788"/>
        <property type="gene ID" value="CYQ11_25625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="41"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="797" mass="81869" checksum="C96B477D41D5C8E3" modified="2018-01-31" version="1">MGGSTFETTLEKSDRTLAPLPTAPAPADRCPPPGTARVRLVFAGLMLTLLLAALDQTVVATALPKIVGELHGPDRMSWVVTAYLLTSTITLPLYGKLGDLSGRKAVFLVAVAVFVAGSALAGWSRTMDQLIAFRAVQGAGAGGLLVGVQAIVADLVPARRRGRYMGAVGAAYGLASVAGPLLGGLFTDRASWRWCFYVNVPLGLVTLAVVAAGLHLPRPPRRARFDVLGALLLTASTTCAVLVTTWGGTEYAWTSRTVLGLAAGAVGTALLFTVVEHFAAEPIIPPHLFRDSVFTVTALVGTVTGVGLFGAAGYLPAFLQMADGVGATESGLLMLPMMGGIVAASLVSGHLISRTGHYKLLPILGGALSAEGMYLLSHLDAQTGRLVYSLWMAILGVGIGLALPVLVLAVQNSTDPADVGTATSAHHYLRQIGGSVGAAVLGTLFAHRLTAALAAELPPRAGLPAPDSLTPQLVHALPAPLRDGYVRAYADAMPRVLLYLVPVLIVGFLLAFLLKEKPLVSHNAPEAVVPSARPAPPAEPAPYVAGIPVTGAVQHHDGTTVPRAALTLIDVQGRQIGRGASGEDGRYALSTPGTGSYVLIAAAGGHQPQAVTVTVGERPVELDVVLGGAGRLAGTVRTADGTPVREALVTLTNVHGEVVASTRTGIEGGYVIDELVAGEYTLAASAPAFRPAALQVTVQSARETRQDVELAGGAVLRGTVRASGGRPVDDARITLLDAAGNVVDSTITGADGAFRFVDLSAGEYTVVAAGYPPVATVLQVAGGGRTERDLQLGHADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF0</accession>
    <name>A0A2G1XAF0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32895</name>
        <name evidence="4" type="ORF">CYQ11_25945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48217">
        <property type="protein sequence ID" value="PHQ48217"/>
        <property type="gene ID" value="BLA24_32895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15844">
        <property type="protein sequence ID" value="PPT15844"/>
        <property type="gene ID" value="CYQ11_25945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="31724" checksum="7897B9EBB0F65BD6" modified="2018-01-31" version="1">MRLPVPLSGVVPPLCTPLDASGDVDPRSLAALVEHVLAAGAAAVFALGTSGESAHLSDAQRRTALRAVVDAVAGRVPVLAGAIDMTTARVLDQARAAAALGADAVVATAPFYAGAHPAEVADHFRRVREAVDLPLIAYDIPPAVHTKLSAATVLALAEDRTLAGLKDSSGDLGALRRLLLALRRDGLDRSFAVLTGSELTVDAALLAGAHGVVPGLGNVDPAGYVRLYEHARAGRWAEAAAEQDRLAGLFALVEAGDPALMSGGASALGGFKAALRLLGVIDCATTAAPQTPLPAAAVTRVRRLLEEGGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP8</accession>
    <accession>A0A346M2I9</accession>
    <name>A0A2G1XAP8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">BcmF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bcmF</name>
        <name evidence="7" type="ORF">BLA24_33475</name>
        <name evidence="8" type="ORF">CYQ11_26525</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <title>Biosynthesis of biocyclomycin.</title>
            <authorList>
                <person name="Meng S."/>
                <person name="Pan H.-X."/>
                <person name="Tang G.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MG018995">
        <property type="protein sequence ID" value="AXQ04977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48314">
        <property type="protein sequence ID" value="PHQ48314"/>
        <property type="gene ID" value="BLA24_33475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15945">
        <property type="protein sequence ID" value="PPT15945"/>
        <property type="gene ID" value="CYQ11_26525"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="153"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AXQ04977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="296" mass="33482" checksum="F0365F7F8F3E5F56" modified="2018-01-31" version="1">MTTVVDNEGHLHLPTARVTAGRLLFDAAEGADQALALGAFCLAVPEDLDVEPGLRFCRSFYEPAEPGTADRYRGHREDGHADSKLGYEDRPDQVEQLQLESHLWSRYLPEEVTALLERMKDLTLDALYGVFDVAGIPEHDRETVTGGARQDTGLCYTTVNHYRADLSDRAGIVEHSDSGFITLICTDQPGYEILHEGRWRPVREEPGHFVVNLGDAFRVLTRKLPRPVTAVYHRVPELRPDGAAHHRSSFTIYMGPRYDMMLHQYAADGTLHEYQGFRDFSVEKSKKLGYEFHSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB56</accession>
    <name>A0A2G1XB56_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29165</name>
        <name evidence="3" type="ORF">CYQ11_06310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48446">
        <property type="protein sequence ID" value="PHQ48446"/>
        <property type="gene ID" value="BLA24_29165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12558">
        <property type="protein sequence ID" value="PPT12558"/>
        <property type="gene ID" value="CYQ11_06310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="344" mass="34614" checksum="77C77C4E14F22978" modified="2018-01-31" version="1">MVCTPGGPSRLLQEARQAVTGRAALLVIGTLVLQLGFIASYIGAFHHPVPKDISLGVVAPRQISGQLVDKLRGLPGDPLDPRPVRDAPEARRQIGERDLDAALVVDPRGTTDTLLTAGGAGASLAQAAEAVVTRAEKAEGRTLRVIDTAPAASGDARGLTSFYLVVGWCVGGYLCAAILAISAGARPANLHRAVIRLGAIACYAVCAGLLGAVIAGPVLDALPGSLAALWGLGALVVFAVGALTLALQGLAGVVGIGLAIGLVVVLGNPSAGGAYPYPLLPPFWRAIGPALPPGAGTWSARSVAYFDGNALTGPLLVLSAWAVAGAVVALVCAAVRGPRSPADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB86</accession>
    <name>A0A2G1XB86_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_29400</name>
        <name evidence="8" type="ORF">CYQ11_06075</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48480">
        <property type="protein sequence ID" value="PHQ48480"/>
        <property type="gene ID" value="BLA24_29400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12522">
        <property type="protein sequence ID" value="PPT12522"/>
        <property type="gene ID" value="CYQ11_06075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="51336" checksum="C016F5F0E9177404" modified="2018-01-31" version="1">MTSPSPAPARGEQRNETVIVFALSLAAMVVSMMQTLVVPILGLIQDDLNTTSANVSWVTTATLLSAAVFTPLLGRFGDQHGKKKTLVGVLIVMVAGSVLAAVTHSLLWLIVGRVLQGAATAIFPLALSVLREEVRPAKLPGAMAMVSGTLAFGSGLALVATGLLTSGDHPDYRSAFWLATGLAALALLAVVTLVPATRETTGGRTDVLGALTLAATLVLLLLPITQGHEWGWSSARTLGCFAGAVVMAALWTVVERKVREPLVDMRMFVHRPVLFANIAGLLVGFGSFALFIGVSYLVQMPSKITGYGFDASVLRASVEYLLPSTIVSLLAAPVGGQLVRHKGPRLVLLLASLIGTAGFVWIALDHDHTVSVIAAGMFVGAAISFGYAAMPAVIVASVPHHQTGIANGINSISRSTGSAIGSAMITTVLASKSIEHLPPGVPKLPAESQFSLTFVIAGTAFCLVALVAGLGLRKIAAPRQAAVAAPAPAADAGSATTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBF1</accession>
    <name>A0A2G1XBF1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_29960</name>
        <name evidence="6" type="ORF">CYQ11_05510</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48574">
        <property type="protein sequence ID" value="PHQ48574"/>
        <property type="gene ID" value="BLA24_29960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12423">
        <property type="protein sequence ID" value="PPT12423"/>
        <property type="gene ID" value="CYQ11_05510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="23556" checksum="A8ABD845DB84E3D9" modified="2018-01-31" version="1">MNERATIRVLLVDDDPIVRAGLRLMLGGAPDIEVVAEAADGAEVEALVEAHTPDVVLMDIRMPTVDGLAATEALRGRPRPPEVLVLTTFHTDDHVLRALRAGAAGFVLKHTPPQRIVEAIRTVAAGEPVLSPAVTRQLIAQVSDGGHRGRAADARRRLAALADREREVAVAVGRGRSNAEIATELFMSVPTVKTHVSRILAKLALNNRVQIALLVNDAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBF7</accession>
    <name>A0A2G1XBF7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">BLA24_29735</name>
        <name evidence="10" type="ORF">CYQ11_05740</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48535">
        <property type="protein sequence ID" value="PHQ48535"/>
        <property type="gene ID" value="BLA24_29735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12465">
        <property type="protein sequence ID" value="PPT12465"/>
        <property type="gene ID" value="CYQ11_05740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="9736" checksum="76493A4F795C66D2" modified="2018-01-31" version="1">MFGRLGAPEIILILVVVVLLFGAKKLPDMARSLGKSARILKSEAKAMKSDGQDNAAAPSDPPAGEQGPRTIKAAPGDVTSRPVGEPTDRTTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM2</accession>
    <name>A0A2G1XCM2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22955</name>
        <name evidence="3" type="ORF">CYQ11_23120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48968">
        <property type="protein sequence ID" value="PHQ48968"/>
        <property type="gene ID" value="BLA24_22955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15387">
        <property type="protein sequence ID" value="PPT15387"/>
        <property type="gene ID" value="CYQ11_23120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="109" mass="12028" checksum="06630C249C35060C" modified="2018-01-31" version="1">MGDKFKLEDDKLTSLAKDLGHMHDTLEGRITALNGVIDSVEGHWKGIAANAYNELQRQVNDDVRRLKELLSFTKDAIVASDKGFTQEEHNQLNNFKGVASAGILGRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCX6</accession>
    <name>A0A2G1XCX6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_23585</name>
        <name evidence="12" type="ORF">CYQ11_22485</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49070">
        <property type="protein sequence ID" value="PHQ49070"/>
        <property type="gene ID" value="BLA24_23585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15284">
        <property type="protein sequence ID" value="PPT15284"/>
        <property type="gene ID" value="CYQ11_22485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="10">
        <location>
            <begin position="107"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="393"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="580"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="954"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1216" mass="126862" checksum="07CA12EF7221048F" modified="2018-01-31" version="1">MQGRFKRDGSAAAEPEPRGATDRGTPAGTPVETPGGGDSAAEPTKAKGATGPGSRIALRNWRISTRLVSLLALPVVAATTLGGLRIQTSLQNVDQLDHMKLLTDMTSRATKLADALQEERDRSAGPLVAKNSKADAIVASREKTDREIQAFGSTTAKVKPNDPTMVGVRTTIVEITRQLKKIQDVRKDAYTDESYISQTVGNYDALITSLLSLSQDMAQATSNSDMITATRALATFSSAKEYASIQRAVISAALANPKGAQLSANDHQYGASAHENEDEALKRFASIRAGDSEELLKGLNGGIADITEATTFAERVFGNSDALKSDHKSYQDWYDQDTIKLSEMSKIEQTLVTQMDQKARELRDDAQNEAYLNGVLIILVLGISLVGAFVVARSMVRSLRRLQETAQKVAEERLPELVKQLSETDPQDVDTSVESVGVHSRDEIGKVAAAFDHVHQEAVRLAAEQALLRGNVNAMFTNLSRRSQGLIQRQLSLISELESREADPDQLSSLFRLDHLATRMRRNGENLLVLAGEEPGRRWTRPVPLVDVLRAAASEVEQYERIELSGVPPTEVAGRVVNDLVHLLAELLENATSFSSPQTKVKVTGHALPDGRVLVEIHDTGIGLSPEDLAAINERLASPPTVDVSVSRRMGLFVVGRLSLRHGIRIQLRPSDSGGTTALVMLPVDVAQGGKKPAPGIPGAGGPGGGPGLPAGPGQPRQQTPTSGPRPAPAPVPRPGTTDSGLPKRQQGPAGGPAGGAATGSLFDTAPRKGAPGAGGAPAGRGAAGPAAVPPPPGAGGRPQLPARGAGDAGRQEPNWAGGQPPAGGRKPKQAPVDDWPLSGNGSPRGAQDAPRGHEGHENSGRPAGPSNPAARPNPERAQLSGGPGDTAQFPPITDESGPQRPAPGRPGLPGGAPQADGRGGTAEFPAIGAGPSGERPGGTSGERLPESTGQFGLPAPGTGQNGTTGQFPQSAPGTQQDSTTGQFGLPAGPSGTGQFDLPAGHGDAPASTSGEYARPHGGDAPSVGTGQFEQPRDFAQPEDDDPLTSTTGQFSRPAVGASSPLFEELESRWFRGGAGESAVPEQPADSARPAPRRAAQPGPQAPAPQAGPPARQGSAQDDWASSPNDERWRRAEQVREPAAGGITSSGLPRRVPRANLVEGTAETQSLPTGPQVSRAPDDVRGRLTNLRRGIQQGRQAGNGSTTGSHHVGPTHQQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCY0</accession>
    <name>A0A2G1XCY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23595</name>
        <name evidence="3" type="ORF">CYQ11_22475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49072">
        <property type="protein sequence ID" value="PHQ49072"/>
        <property type="gene ID" value="BLA24_23595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15282">
        <property type="protein sequence ID" value="PPT15282"/>
        <property type="gene ID" value="CYQ11_22475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="136" mass="14193" checksum="D10D1A16EFC8D970" modified="2018-01-31" version="1">MTPPASPGPYGASHHAPYGSDEGDQPLVRPYAMTGGRTRPRYQLAIEALVSSTADPAHLGGLLPEHQRICHLCREVKSVAEISALLSMPLGVARILVADLAEAGMVAIHQPGGGTEAGGTPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD95</accession>
    <name>A0A2G1XD95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24385</name>
        <name evidence="4" type="ORF">CYQ11_21685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49208">
        <property type="protein sequence ID" value="PHQ49208"/>
        <property type="gene ID" value="BLA24_24385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15142">
        <property type="protein sequence ID" value="PPT15142"/>
        <property type="gene ID" value="CYQ11_21685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="21101" checksum="D2F10C761CDE9329" modified="2018-01-31" version="1">MIVTLILVCEVGFWVLLAGGLSLRYLARMPRTGIAVLLLEPVLELVLLIATAVDLRNGASADWKHGLAAVYIGYSVGLGHSTITWVDQRFAHRFAGGPPPVKPPKHGAARTAYEWKVAGRWILAAAVAAALLQAAVWYVGDSGDVSSLRAWQTKMLIVVGINLAIAVSYTIWPKQPKDKGEDGDPDGAVPDLVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDB9</accession>
    <name>A0A2G1XDB9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_24300</name>
        <name evidence="9" type="ORF">CYQ11_21770</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49191">
        <property type="protein sequence ID" value="PHQ49191"/>
        <property type="gene ID" value="BLA24_24300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15159">
        <property type="protein sequence ID" value="PPT15159"/>
        <property type="gene ID" value="CYQ11_21770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="32136" checksum="FDEE8D916E3898AF" modified="2018-01-31" version="1">MNTPQQHTAPPQQPPVPPASPAFPPQPQPQTQGYWPGQTPVGGYVSPIPLRRATLTDALAAEWTKIRSLRSTMWTLGTMVVLTVGIGLLIAVALGSTNGSTGENTGSVLVLGLYGVMLGVMCVITLGVLTISSEYGTGLIRTTLTACPDRARVLTAKAVVFFLLTFTITLLSTGIVAVADDVFAGHLASVDPSGEQWVRATIGMSLFVSLLGVVSLAVGTVVRHAAGAITTMLGIVLLPLIMALFMDTSSLQDVRDALFGYSIPSQMAALYDVNTLGGPTGWTPLWIMLGATAVALGGAYTSLLKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDD4</accession>
    <name>A0A2G1XDD4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_24370</name>
        <name evidence="11" type="ORF">CYQ11_21700</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49205">
        <property type="protein sequence ID" value="PHQ49205"/>
        <property type="gene ID" value="BLA24_24370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15145">
        <property type="protein sequence ID" value="PPT15145"/>
        <property type="gene ID" value="CYQ11_21700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758831" evidence="6">
        <location>
            <begin position="41"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="8">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="246"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="678" mass="71656" checksum="1A4FB6D1FFBCD063" modified="2018-01-31" version="1">MSTGTSGQRRHPTFRAVVAACAALLLPLAALVGLAAPAQAAPSATATFVKTSDWGTGFQAQWTVKNTGSTPLDGWTVEWDFPSSTTIGSYWDALITSAGTHHTARNREYNGTVAPGASVTFGFVGAGDGAPEGCRLNGGPCDGSSVDSPPSAPGKPASTAVTADSIALKWDAATDDKGVKNYDVYRGSAKVATVAKLAYTDTGLTADTEYTYTVVARDTAGQTGPASAPLTVRTTGGGDPQPGTGYVKAGYFVQWGIYGRGYTVKSLDDRGAAARLTHLNYSFSNIDPLNLTCLNGVTKATTPNPQDPGQGDGAGDSWADYEKGFGAGESVDGVGDTWDQPLAGNFNQLKKLKAKYPKLKVNISVGGWTYSKYFSDVAKTDASRQKFVKSCIDMYIKGNLPVTGGRGGDGVAAGIFDGFDIDWEWPGSEGHAGNHVSTDDKANNTLLFAEFRKQLDALSATTGRKYLLTAFTPADPAKIEAGWDITTKDGTPSVFDFMDFANVQGYDFHGSGSDNSWEPNRTGHQGNLYADAKDPYDTKFSVERTVQTYLDAGVDPRKVVLGLAFYGRGWQQVADGGVHGVWQSAGGAAPGQFPEEAGTRGYDNLLASVPNLTVHHDEQSVATYGYTGAGGQWWTFDDAWSIGRKTAWLKPKKLGGVMIWEMSGDSGTLMTAVDNGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDE7</accession>
    <name>A0A2G1XDE7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">AtrA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24695</name>
        <name evidence="4" type="ORF">CYQ11_21375</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49263">
        <property type="protein sequence ID" value="PHQ49263"/>
        <property type="gene ID" value="BLA24_24695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15085">
        <property type="protein sequence ID" value="PPT15085"/>
        <property type="gene ID" value="CYQ11_21375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="68"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="321" mass="33612" checksum="6C3E0A69EEFDF784" modified="2018-01-31" version="1">MTASTTPRPAAARSRLAAAGAIAVAGALLLTGCGDQRDKTGNEAGQSAQGNQAPLFGKLPKKIQDSKVIKVGSDIAYPPVEFKKDGKVVGVDPDIAAALGKQLGVKVEFNNGTFDNLLTGLRSKRYDIAMSAMTDTKDRQEGVDSKTGNKVGEGVDFVDYFNAGVSLYTKKGDTKGIGSWDDLCGKKVAVQRGTVSHDLAKAQSDKCEKDDKDKISIEAFDTDLEAQTRLKAGGVEAVSSDFPVAAYAIKTSGGGNDFESVGEQVEAAPYGIAVAKDNTQLRDALKEALDAIIKNGEYDKVVQTWGVDAGAIKEAKVNGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDE8</accession>
    <name>A0A2G1XDE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24660</name>
        <name evidence="2" type="ORF">CYQ11_21410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49256">
        <property type="protein sequence ID" value="PHQ49256"/>
        <property type="gene ID" value="BLA24_24660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15092">
        <property type="protein sequence ID" value="PPT15092"/>
        <property type="gene ID" value="CYQ11_21410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="59" mass="7086" checksum="7E16F5A7B0F1E6AC" modified="2018-01-31" version="1">MYFTDRGIEELENRRGEEEVSLAWVAERLREFVDLNPDFEVPVERLATWLARLDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDM4</accession>
    <name>A0A2G1XDM4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24735</name>
        <name evidence="4" type="ORF">CYQ11_21335</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49269">
        <property type="protein sequence ID" value="PHQ49269"/>
        <property type="gene ID" value="BLA24_24735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15079">
        <property type="protein sequence ID" value="PPT15079"/>
        <property type="gene ID" value="CYQ11_21335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758832" evidence="2">
        <location>
            <begin position="34"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="23572" checksum="9F51D297CA651611" modified="2018-01-31" version="1">MSQSIRTRRVASAVLTATAVTALTLSTAGTAGAAGAAGAATEAAPRHTSGTAGLKGVDYDTWQRDVRAVVAQATPYVTERTAGTAADGRKPAVVLDIDNSSLETDFHWTTFPTPAIRPVLELTRYAHARGAAIFFVTARPGILDSVTEWNLRQVGYPVSGLYVRHLPDLFQDVSTYKTAKRAEIEARGYTIVANIGNHTTDLVGGHAERTFKLPDYDGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDU5</accession>
    <name>A0A2G1XDU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_25520</name>
        <name evidence="8" type="ORF">CYQ11_20555</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49407">
        <property type="protein sequence ID" value="PHQ49407"/>
        <property type="gene ID" value="BLA24_25520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14943">
        <property type="protein sequence ID" value="PPT14943"/>
        <property type="gene ID" value="CYQ11_20555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="33542" checksum="D6782CB657F1346C" modified="2018-01-31" version="1">MGRYVIRRLLQMIPVFIGSTFLIFFMVYALGDPVAALFGDKAPDPATAARIRKDLYLDAPLWKQYLHYMGQILTGNFGTAFNGQEVIDLMADAFPVTLRLTLVAVLFEIVVGITLGLLSGLRRGRAVDTTVLLLTLVVVSIPTFVSGYVLQYLFGVKWGAVSPSVSPAAPLDELLLPGVVLGLVSLAYVTRLTRTSLAENSRADYLRTAVAKGLPRHRVVTRHLLRNSLIPVVTFIGTDVGALMGGAIVTERIFNIHGVGFQLYQGVLRQNSPTVVGFVTILVIVFLLANLLVDLLYAVLDPRIRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDU7</accession>
    <name>A0A2G1XDU7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25535</name>
        <name evidence="2" type="ORF">CYQ11_20540</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49410">
        <property type="protein sequence ID" value="PHQ49410"/>
        <property type="gene ID" value="BLA24_25535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14940">
        <property type="protein sequence ID" value="PPT14940"/>
        <property type="gene ID" value="CYQ11_20540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="185" mass="20186" checksum="539A67A2E699B739" modified="2018-01-31" version="1">MRGVAAGGLSPYESALAALLGTWLLLAVLAQLGPVAPWLGQAVGRLDVLGLVPRYHLVATCPATHDYHLLIRTRPPGGRFGAWREVTTEPRRRRWNAVWNPDRRHHQQLFDLAMALARTDARSDDPATPLPVPYLLLLRHVSALAGRTEGAQVQFLIARSAGHRPAEQPAALFVSQAHRTGAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDW6</accession>
    <name>A0A2G1XDW6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_25595</name>
        <name evidence="8" type="ORF">CYQ11_20475</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49418">
        <property type="protein sequence ID" value="PHQ49418"/>
        <property type="gene ID" value="BLA24_25595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14932">
        <property type="protein sequence ID" value="PPT14932"/>
        <property type="gene ID" value="CYQ11_20475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="47"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="383" mass="41774" checksum="7F26500501175F48" modified="2018-01-31" version="1">MAETGKKDEAVAEATPNVSEVEVSDASTTAEVEAVLDAPVERGEPILQVRNLVKHFPLTQGILFKKQVGAVKAVDGVSFDLYQGETLGIVGESGCGKSTVAKLLMTLETATSGEVFYKGQDITKLSGRALKAVRRNIQMVFQDPYTSLNPRMTVGDIIGEPFDIHPEVAPKGDRRKRVRELLDVVGLNPEYINRYPHQFSGGQRQRIGIARGLALNPEIIICDEPVSALDVSVQAQVINLMEKLQDEFNLSYLFIAHDLSIVRHISDRVGVMYLGKMAEIGTDAAIYDHPTHPYTQALLSAVPVPDPDAREGRERIILTGDVPSPANPPSGCRFRTRCWKAQDKCAEEVPLLAVPEVFVGKKTPAAHESACHFAEEKQVVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDX7</accession>
    <name>A0A2G1XDX7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_25645</name>
        <name evidence="5" type="ORF">CYQ11_20425</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49428">
        <property type="protein sequence ID" value="PHQ49428"/>
        <property type="gene ID" value="BLA24_25645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14922">
        <property type="protein sequence ID" value="PPT14922"/>
        <property type="gene ID" value="CYQ11_20425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="29003" checksum="34FC767647871444" modified="2018-01-31" version="1">MSYQARFKVWRGDADGGGLVDYEVAVHEGEVVLDIIHRLQATAAPDLAVRWNCKAGKCGSCSAEINGRPRLMCMTRMSVFDPAETVTVTPMRTFPVTRDLVTDVSYNYVKAREVPSFVPPARLKPGEYRMRQEDVGRIQEFRKCIECFLCQNTCHVVRDHEENKTNFAGPRFLMRVAELDMHPLDAADEAGVDRRQGAREDHGLGYCNITKCCTEVCPEHIKITDNALIPLKERVVDRSYDPLVWLGSKIRRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE29</accession>
    <name>A0A2G1XE29_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25990</name>
        <name evidence="3" type="ORF">CYQ11_20075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49490">
        <property type="protein sequence ID" value="PHQ49490"/>
        <property type="gene ID" value="BLA24_25990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14859">
        <property type="protein sequence ID" value="PPT14859"/>
        <property type="gene ID" value="CYQ11_20075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="31791" checksum="35E4FED770713D7D" modified="2018-01-31" version="1">MLSPARSLTLHAESGKELPRIDAFEPLYNIGCRPRHGEVVMIAGRSGTQKSGLALFWAAQMNLPTLYFSADMSAFTASSRLASMMTGDTTTMVEAGMAAGGRYREEYLAALAHLNITFSFGSPITWKAVDEELEAYVELWDAYPAVMVFDNLMDFDSAESDYTEQMAVMSGLTELSRATGATVIVLHHASDKSWEAKSDPWAPPSRDQVKGGLSEKPELSLSVALDPTSMEFRIAVIKQRMGACDPTAKRYATLRCQPEYTRFAKPEPRISPLPPAAPRQWSPLDALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE69</accession>
    <name>A0A2G1XE69_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25865</name>
        <name evidence="3" type="ORF">CYQ11_20205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49469">
        <property type="protein sequence ID" value="PHQ49469"/>
        <property type="gene ID" value="BLA24_25865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14881">
        <property type="protein sequence ID" value="PPT14881"/>
        <property type="gene ID" value="CYQ11_20205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="52324" checksum="330FD192692094EF" modified="2018-01-31" version="1">MVFAASPLALAQELLAILHRDGDRLRRIDDYLHGRHSDPYMPPQADDEYRLLARRAVSNWMPLLVSTPAQALYVDGYRPGSGTSATSEPDSETPEWEHWQRSRLDGRQAAVYRGALTYGHAFTMTERGRSGDVITRGLSALKTSALYEDPANDHTPHAALTVTTWPQGDQPGTARLWDAKREYVVTFRSLSDEKSVRLQGGTLHGSSECPVTRFAAWVDLEGRTLGVIEPMICVQDRINQTVFDLLLAQSYGSTKVRTVTGMAPPVQRDPETGEPVLDAQGNPIPVRINHNSRRFLFAEDPDVKFGSLDETPLGGFIDSIEMSIRHLSALAQVPPQTILGQIANLSAEALQAAEVSLSRMISEVRTGFGESWERVFRLAGELAGNASSAEDFRGEVVWRDMESRSLAQSADALGKLRTQLGIPERGLWRRVPGVTQTELEDWEQMREDDDSVGQLAGALNRATPEDAAPIEKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE79</accession>
    <name>A0A2G1XE79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25930</name>
        <name evidence="3" type="ORF">CYQ11_20140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49479">
        <property type="protein sequence ID" value="PHQ49479"/>
        <property type="gene ID" value="BLA24_25930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14871">
        <property type="protein sequence ID" value="PPT14871"/>
        <property type="gene ID" value="CYQ11_20140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029432">
        <property type="entry name" value="Sipho_Gp37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14594">
        <property type="entry name" value="Sipho_Gp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="730" mass="77996" checksum="9D0216378654C96C" modified="2018-01-31" version="1">MRLQDLTVEVRDKNLTRLGLIRPEDLALEVTDTFNNVGTWKLTLASEHPLADTLRTPGSGLIITGHDDVLMSGPVVSSEYAATPEDRRGSIAFEGVSDTVILSDMLAWPEPTNPDVGKQATGHDERSGAAETVMHGYVNANCGPAAPAARRRGNLVMGPNPGRGPMVKKSARFPTLGELLTEIASVAGLGFRIVQRASQLVFETYAVADRTREVRLDVLAGTLAGQRVSVSTPGATRVIVAGQGEQEDRTLIPVDNTTSISAETDWGRRIERFVDQRNTDDEKELTQAGNEVLAEAGKTATAVQAVPVEDSPMEFGVDWRLGDRVTIVAGGQELTAPVTGLVIKAGEDGFHVGTLLGDPSPFDPNAAATAQAATTQSRVSALERTAEASPPGPREVWPESFTQASPPTAYPDGASIMILSAEQATAGGWDFGGKYGHVTTRKEPWGDASQTWSRVHAATTPHEEWVRGGNARTGWGPWRMITYKQILSADTINQATDPTAYPYEDSRLYLDSAASKAGGWSFAPMSGYVWTTGTTTGYTTQRWSRTHGGAEPHEEWVRGGSPSSGWSPWRQTAFRDNTARGLIALAPLNASGYVGDTPTLIYYWTFPAEARRMYRFGLRISSVDTDGTGDSGSGTRYAKQSAYTVARWASGTSVTASSPALGDMLTTCFNDDSDSSSGLSATFHLNGAPAGLTTIGVFLNARRAAATYGQVRYLTGAGSELWIEDVGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE89</accession>
    <name>A0A2G1XE89_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_03790</name>
        <name evidence="5" type="ORF">BLA24_03805</name>
        <name evidence="3" type="ORF">BLA24_26240</name>
        <name evidence="6" type="ORF">CYQ11_19400</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000053">
        <property type="protein sequence ID" value="PHQ53073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000053">
        <property type="protein sequence ID" value="PHQ53074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49532">
        <property type="protein sequence ID" value="PHQ49532"/>
        <property type="gene ID" value="BLA24_26240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53073">
        <property type="protein sequence ID" value="PHQ53073"/>
        <property type="gene ID" value="BLA24_03790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53074">
        <property type="protein sequence ID" value="PHQ53074"/>
        <property type="gene ID" value="BLA24_03805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14748">
        <property type="protein sequence ID" value="PPT14748"/>
        <property type="gene ID" value="CYQ11_19400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="28481" checksum="1B3C95C07C7F6A93" modified="2018-01-31" version="1">MKLRDLVYRLYARRVEGRLDHAQVPKHIGVILDGNRRWARADGRTPEQGHQAGADKISELLGWCAETDVEVVTLWMLSTDNLDRPAVELNPLLGIIENTVRGLAADGRWRVHHVGTLDLLPAQTQSVLKEAEQDTDGIDGILVNVAVGYGGRQEIADAVRSLVLEAAENGTSHEELAETVDVDAITKHLYTRGQPDPDLIIRTSGEQRLSGFMLWQSAHSEYYFCEVFWPAFRKVDFLRALRDYAARHRRYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE91</accession>
    <name>A0A2G1XE91_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-aminoacylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">N-acyl-D-amino-acid deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26365</name>
        <name evidence="3" type="ORF">CYQ11_19275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49553">
        <property type="protein sequence ID" value="PHQ49553"/>
        <property type="gene ID" value="BLA24_26365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14726">
        <property type="protein sequence ID" value="PPT14726"/>
        <property type="gene ID" value="CYQ11_19275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="537" mass="56964" checksum="6A0B030AA06DD205" modified="2018-01-31" version="1">MDLVIRGAAVIDGTGAPSYRADVALADGRIAAIAREGDRRPTARRVLDAHGLALAPGFVDMHAHSDLALLRDPAHTAKVAQGVTLEVLGQDGLSYAPVDDRTLAGVRTQITGWNGDGHDVDFSWRSVGGYLDRLDHGHGGEGVAVDAAYLVPQGTVRMLAVGWEDRPATAAELARMRRLVAEGLEQGAVGMSSGLTYTPGMYADDAELTELCRVVAAYGGYYCPHHRSYGAGALAAYEEMIAVARTAGCALHLAHAVLNHDGNRGRAPELLTLLDAARAEGVDVSFDSYPYTPGCTTLAALLPSWAGEGGPASLLARLGDDATAGRIRHALEVEGADGCHGVPVDWDTVEVSGVTDPALTPYVGRSLARSARERDEEPWTTARRLLTADRLGTTVLLHVGDEDNVRTLMRHPAHTGGSDGILHGAKPHPRAYGTFPHYLGRYARELGMFSPEECVAHLTSRPAARLRLSDRGLVREGNRADLVLFDPDTVAAGSTFEAPSGLPTGIPYVLIAGRFVMEDGRRTDVLAGRAVRRVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE94</accession>
    <name>A0A2G1XE94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26195</name>
        <name evidence="3" type="ORF">CYQ11_19445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49525">
        <property type="protein sequence ID" value="PHQ49525"/>
        <property type="gene ID" value="BLA24_26195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14755">
        <property type="protein sequence ID" value="PPT14755"/>
        <property type="gene ID" value="CYQ11_19445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="19486" checksum="FF721CADDFBA5990" modified="2018-01-31" version="1">MSIGHTLLGLLESGPRHGYDLKRAFDERFGQDRPLHYGQVYATMSRLLKNGLVEVEGIEQGGGPDRKRYAITDAGVTDVARWLGQPEKPEPYLQSTLYTKVVLALMTGRDAGRLLDAQRSEHLRLMRGLTERKRGGDLADQLICDHALFHLEADLRWLELTAARLDQLATAVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE96</accession>
    <name>A0A2G1XE96_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_26295</name>
        <name evidence="7" type="ORF">CYQ11_19345</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49542">
        <property type="protein sequence ID" value="PHQ49542"/>
        <property type="gene ID" value="BLA24_26295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14738">
        <property type="protein sequence ID" value="PPT14738"/>
        <property type="gene ID" value="CYQ11_19345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758332" evidence="4">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="78"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="20706" checksum="3208D98E08B83811" modified="2018-01-31" version="1">MPVLTTAVVVVAAVTALAPAPADSGPGRAADTTPPVRIDSSAPGLKLRSGAKLAPGRVLDIKSVIESGDGDERREDTNVDVTFALQAEVIFGKDSAGLSPTATARIRAIADEVRRQHATTLRVFGFTDNLGSAEHGLALSKERADAVQRELARDLGSSAITYQIRGYGEQYPLADNATEDGRRKNRRVEVSFPRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEA7</accession>
    <name>A0A2G1XEA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26435</name>
        <name evidence="3" type="ORF">CYQ11_19205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49566">
        <property type="protein sequence ID" value="PHQ49566"/>
        <property type="gene ID" value="BLA24_26435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16668">
        <property type="protein sequence ID" value="PPT16668"/>
        <property type="gene ID" value="CYQ11_19205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="17182" checksum="42B3428CC6315216" modified="2018-01-31" version="1">MTTDLAPGVLDALQHQVAVFARRAEQTRLGGVGRVHNSMDRAAYLLLNRLDQEGPMGVKALAAGMGIDSSTVTRQVAPLVDTGLVKRTSHPEDGRAVVLQLSPRGKARLEEVRASRRELMALCTAGWSEDDRDAFCALLTRFNAALSGIHTALPQVPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEH9</accession>
    <name>A0A2G1XEH9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_26825</name>
        <name evidence="11" type="ORF">CYQ11_18810</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49633">
        <property type="protein sequence ID" value="PHQ49633"/>
        <property type="gene ID" value="BLA24_26825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14646">
        <property type="protein sequence ID" value="PPT14646"/>
        <property type="gene ID" value="CYQ11_18810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="169" mass="17466" checksum="8F48354D72485691" modified="2018-01-31" version="1">MTTPHVIVVMGVAGTGKTTIGPLVAEALGLPYAEGDDFHPAANVAKMSAGTPLDDADRAPWLDAIGAWAAGRAGRGGVVSCSALKRAYRDRLRAAAPAGAVVFLHLTGERELIAGRMAARTGHFMTSRLLDSQFATLEPLGPDETGVVVDVAPGPEVIAEQAVAALRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL1</accession>
    <name>A0A2G1XEL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type 2 lantipeptide synthetase LanM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27085</name>
        <name evidence="3" type="ORF">CYQ11_18545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49677">
        <property type="protein sequence ID" value="PHQ49677"/>
        <property type="gene ID" value="BLA24_27085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14600">
        <property type="protein sequence ID" value="PPT14600"/>
        <property type="gene ID" value="CYQ11_18545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04792">
        <property type="entry name" value="LanM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017146">
        <property type="entry name" value="Lanti_2_LanM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037228">
        <property type="entry name" value="Lant_mod_RumM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03897">
        <property type="entry name" value="lanti_2_LanM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="212"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1068" mass="115488" checksum="6452A680A6BAE9B4" modified="2018-01-31" version="1">MTGDRRITIKNAESSAYSYERTLLTGGSPAEATAKVAAWRESAFMSEELFRDRLARSGMTEETFGALITGGTFTAAPEAVAWAGELTAILEAAGADAEVPDVETSLFGYVFPRLPFGSLIGRFLTHYEARLAEGLSDGPEVLRHLAGSVRRQFSAALADRLLRVCARTLIVELNGARVDGKLEGATPEERYEDYDRRLLADPDYLELFFAAYPVLGRSMVECGRQWTAYVTEVLRRLVADEEILRTAGLVNGPVGRLADIALDLGDGHNRGRSVAMLTFEDGERVVYKPRSVAAEAVYSALAETVNGYGPRFHNMNMKVVERDDYGWCEFIAHEPCSSPEEIKAFYWRIGGTLANLLHLGAIDFHMENIIAAGAYPVPIDLETIFQHPPFDGEAVTAHQQAMRRLFQGVLATGILPARVFGDRRVGGVDLSAINGGASTETSKAVPTIVDAYQDTMRIEARTAEMGQAKNRPYADGVEVRPEDHMDEVIAGFSETYEIIEKNAPVFAAMLNASADVEIRHLARQTRRYGLFLTESFHPRYLRNALDREQLLDKLWATVETRPDLAPLVESEKRQLINGDIPCFRTQPGATGIHAPGYDAVDDFFAAPSLVEMREKLAGFSPEHRRAQEQIVRETMSTLLTNGGRERHRPVPGSGRYDPAAAAALARQLASKLADQAILGADDCSWLGVSVDGGQEDALTYRPVGTALYDGLAGLAVMYAHAGALFGDERFADLARRSTVPVLDHLRDARENGLADTTGAFSGIAGLLYALDQMAAVTGDSRYADHIEQALPLLLRVAQEETSPDVIGGLAGGAIVAMNLHRQYGSPQLREIAALCARRLQETSIDVEGAAGWKPAPNSPPLGGFSHGSAGIGWVLFELASFLGDGELRELGRRAVDFDRRLFVPGEGRWRDLRLEQGAISRAPEPAGWWCNGGAGIGLSRLLIARVDDDPELLTEAEAALSAVYDGGFGQNHSLCHGDFGNLALLTLAAETLPDAGRAAHWAGARDRFAHGVISQIQSSGAISGIPAGRIDVPGMMIGTAGICLGLMRLAEPGRVPDVLSLQARATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEM5</accession>
    <name>A0A2G1XEM5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26805</name>
        <name evidence="5" type="ORF">CYQ11_18830</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49629">
        <property type="protein sequence ID" value="PHQ49629"/>
        <property type="gene ID" value="BLA24_26805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14650">
        <property type="protein sequence ID" value="PPT14650"/>
        <property type="gene ID" value="CYQ11_18830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="28"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="381" mass="42046" checksum="F8C51E6ED8264476" modified="2018-01-31" version="1">MTTTAATPALPRARTAPPEEPRAHGRLRALDGLRLVAALMVALYHYGGRDGDVSRAWGASPRHEFPHLSPAFAYGCLGVQIFFVISGFVICMSGWGRPLRSFVASRAARLYPAYWVAIALVTVAFALPWVTYKTVSASDTLVNLTMLQQPVGAERVLGVCWTLWAELRFYALFALFVVLPGASRQRVMLFCAVWTLMTVVTTASHVEFLRVVFMPEYSAYFIGGVGLYLVHRFGHDALAWGIVAVSFLLGQHYAVAGLWHPPNPHYFSYRSPYVIIAVLALGYAAVAAVALGRTTWANWRWLPFAGALTYPFYLVHEHLGWVVIGGLHRGLGLPSAVTFALTLALMLLLAWALHRCVERRFTPALRRALEGGRGRPDGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEQ5</accession>
    <name>A0A2G1XEQ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enhanced serine sensitivity protein SseB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_23890</name>
        <name evidence="5" type="ORF">CYQ11_22180</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49706">
        <property type="protein sequence ID" value="PHQ49706"/>
        <property type="gene ID" value="BLA24_23890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16719">
        <property type="protein sequence ID" value="PPT16719"/>
        <property type="gene ID" value="CYQ11_22180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SseB_C" evidence="3">
        <location>
            <begin position="156"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="27701" checksum="F61F2ADA5728F8A2" modified="2018-01-31" version="1">MSIPEHPGHYGAPQATDVAAPTLPSTWPANELEGVLAASLGVPGAGARIVEVLGRSSLWIPLPAGGGPDSPDLDLPTVELDGAAYVPVFSSEAEFLRVVGDRMPFAVAPAVEFARGLPPQVGIAVNPDGTVAVPLPPPAVAELCRAGRTALDGDATGGRVRLFEPDWQQEPTAFLAAAGLEFAALPGVRTGRRALASVEGADPALFVGVELDLPDPAARTAAVEAVGRALGAVPVPWPVQLVFLDVAQDPVGDWIRDRVRPFYDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEV4</accession>
    <name>A0A2G1XEV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23690</name>
        <name evidence="3" type="ORF">CYQ11_22385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49699">
        <property type="protein sequence ID" value="PHQ49699"/>
        <property type="gene ID" value="BLA24_23690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16726">
        <property type="protein sequence ID" value="PPT16726"/>
        <property type="gene ID" value="CYQ11_22385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="358"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="43956" checksum="B1CA0B9972C4DC49" modified="2018-01-31" version="1">MRGEYQQLVDEISAALGAPATLEDRDFALIAFGAHGGDDDLELTMDPVRTRSILQRRSTAAVRAWFEAFGIARAQAPLRIPPDPAAGVFKGRICLPVRHRGVVHGYVWLLDEQHLAGLDLRVPFADPRLAQAMETAARIGALLAAEARAGAELGELLRELLTARPAGREAARAVLREALGPTAEGPLALVAVAPWRPAGDGEGDADQPAGDGAASALATQSGVAAMCAVPDALPGGSAALAALVRLRATTSPAPALAAADRLLRSPRAGRAEASGPGGPALAVLAAAGVGTPRRGLEELPEAWAEALAAARAAMAERRLGPVAEWAGIGPYRVLTGLSERRAADPSVLPLLAGTHTELARTAEVFLDCAGQAGRAAAALGIHRQTLYYRLGRVEQLTGLDLDNGEDRLLLHMTLKAARLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF66</accession>
    <name>A0A2G1XF66_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19585</name>
        <name evidence="4" type="ORF">CYQ11_11210</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49845">
        <property type="protein sequence ID" value="PHQ49845"/>
        <property type="gene ID" value="BLA24_19585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13379">
        <property type="protein sequence ID" value="PPT13379"/>
        <property type="gene ID" value="CYQ11_11210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="595" mass="66012" checksum="4507BCE9955E6D81" modified="2018-01-31" version="1">MTTTTANHHLSPAFPGRAPWGTANKLRAWQEGAMGKYIQTQPRDFLAVATPGAGKTTFALTLASWLLHHHVVQQVTVVAPTEHLKKQWAEAAARIGIKLDPEYSAGPLGREYHGVAVTYAGVGVRPMLHRNRCEQRKTLVILDEIHHAGDSKSWGEACLEAFEPATRRLALTGTPFRSDTNPIPFVTYEEGNDGIRRSAADYTYGYGNALGDGVVRPVIFLSYSGNMRWRTKAGDELEARLGEPMTKDAISQAWRTALDPRGDWMPNVLRAADQRLTEVRKSIPDAGALVIASDQESARAYAKLIREITGEGATLVLSDDSGASQRIDDFSQDGSRWMVAVRMVSEGVDVPRLAVGVYATTISTPLFFAQAVGRFVRSRRRGETASVFVPTIPTLLTFANEMEVERDHVLDKPKKEGEEDPYAESEKEMDEANKQQDEDTGEQDMLPFEALESDAVFDRVLYDGAEFGMQAHPGSEEEQDYLGIPGLLEPEQVQLLLQKRQARQIAHSRRKPDEQADLLEIPAERRPVVTHKELLELRKQLNTLVGAYVHQSGKPHGVIHTELRRVCGGPPSAEATAGQLTERINKVREWATRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFI5</accession>
    <name>A0A2G1XFI5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_20495</name>
        <name evidence="6" type="ORF">CYQ11_10285</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49993">
        <property type="protein sequence ID" value="PHQ49993"/>
        <property type="gene ID" value="BLA24_20495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13229">
        <property type="protein sequence ID" value="PPT13229"/>
        <property type="gene ID" value="CYQ11_10285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="20852" checksum="3349A28A1032BB72" modified="2018-01-31" version="1">MNETLVTVVGNVATQPDFRQAANGSAVSRFRLAATVRRWDRQRQEWADAYTSFYTVWAWRALAANVVGSVSVGEPLIVQGKLRIQEQEREGKRWLSADIDAVSIGHDLARGTSAFRRVVPAKPLPVDPVRMAGAQGGSPPGGRRDAPRAMPYDSPGAPSDRPPNPGPDAPEVLPVLVGGGVEVPPAEEQAMAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFX8</accession>
    <name>A0A2G1XFX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_21410</name>
        <name evidence="9" type="ORF">CYQ11_09375</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50144">
        <property type="protein sequence ID" value="PHQ50144"/>
        <property type="gene ID" value="BLA24_21410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13074">
        <property type="protein sequence ID" value="PPT13074"/>
        <property type="gene ID" value="CYQ11_09375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="488" mass="50278" checksum="0E657EB22625516E" modified="2018-01-31" version="1">MSEPRIASDAPSPTTPAPSTTSRSSASPTPALSPLGLATVLLGAALPFLDFFIVNVALPTIDHDLDAGPALLEMVVGGYGVAYAVLLVLGGRLGDMVGRRRLFLWGTAAFGVTSVACGLAPDAWTLVAARVAQGAAAALMLPQVLATIQATTAGHRRTKALSLYSGTAGVVSAVGQVLGGVLVSVDLAGTGWRSIFLINAPIAVVAFVLALRAVPETRSDRPTGVDGWGTVLLSVTLVSLLLPLTEGRSTGWPVWSWVLLAVFPVAAVAFVVVERREERAGRTPLVPPSLLRVHAVRSGLALITPFSIGWGGFMFVLAVALQEGLRLGPLAAGLALVPMCVTFFVGSLAGPRLAARYGRRLATAGALIQAAGLLMVAGTFWFGWDGLDALGTAPGLAVQGLGQGLLMPMTMRLVLSEVPVDKAGVGSGVLVTTQQAFMALGVATLGSLFLSLTPHTGMREALAITWGVQLVTVVVTVLLTLRLPRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG22</accession>
    <name>A0A2G1XG22_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21645</name>
        <name evidence="3" type="ORF">CYQ11_09140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50182">
        <property type="protein sequence ID" value="PHQ50182"/>
        <property type="gene ID" value="BLA24_21645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13035">
        <property type="protein sequence ID" value="PPT13035"/>
        <property type="gene ID" value="CYQ11_09140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="342" mass="37054" checksum="A19F45A4C7740336" modified="2018-01-31" version="1">MSNDKIKSVTLGDGGPEVGVQGLGCMGMSFAYGPTTDVAEARATLERALELGVTLFDTADMYGMGENEKFLAPFVRAHREHVVLATKFAIAPDPEDPTDTTKRTIRNDPPYIRQAVEASLRRLGVDEIDLYYMHRRDPEVPLEESVGAMADLVREGKVKHLGLSEVTGSELRAAQAVHPIAAVQSEWSLFSRDIETSVVAAARELGVALVPYSPLGRGFLTGAFVSADKELSSDDWRRTQPRFTGDNAEANAALLEPVRRIAEAHGATPGQVALAWVQQQARVHGLTVVPIPGTRRRARLEENTAATRVELTADDLAALEPIAGKVAGDRYSDMSHTSADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG70</accession>
    <name>A0A2G1XG70_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21955</name>
        <name evidence="6" type="ORF">CYQ11_08830</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50233">
        <property type="protein sequence ID" value="PHQ50233"/>
        <property type="gene ID" value="BLA24_21955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12982">
        <property type="protein sequence ID" value="PPT12982"/>
        <property type="gene ID" value="CYQ11_08830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="27"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="493" mass="51176" checksum="30938FCEE44424BF" modified="2018-01-31" version="1">MAELVEHGQLFIGGRLADPAAGDGGAVIDVVSPHSEEVIGRVPHASRADVDRAVAAARAAFDSGVWAGLPLAERLAVVTRIKDGLAARHEEIARTVSAQNGSPYSWSVLAQALGAVMVWDSAIAVARGFPYEERRAGALGPLLVRREPVGVVAAVVPWNVPQFVAAAKVAPALLAGCSVVLKPAPETPLDSYVLAEVAAAAGLPEGVLSILPAGRETGEYLVGHPGVDKVSFTGSVAAGKRVMEVAAGHLARVTLELGGKSAAIVLPDADLDAAVAGIVPSAWMNNGQACVAQTRVLAPRSHYAELAERLAAAATALTVGDPLDPATEVGPLVTRRQRQRSLDYIALGRREGAALLAGGGTPAGADRGWYVEPTLFGEVTNAMRIAREEIFGPVVCLLPYEDEEEAVAIADDSDYGLSGSVWTGDVEHGIGIARRVRTGTYSVNTFSLDMLAPFGGYKDSGLGREGGPEGYAEYLEQKTIHLPAGYGRDGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGA4</accession>
    <name>A0A2G1XGA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_22165</name>
        <name evidence="5" type="ORF">CYQ11_08620</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50262">
        <property type="protein sequence ID" value="PHQ50262"/>
        <property type="gene ID" value="BLA24_22165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12952">
        <property type="protein sequence ID" value="PPT12952"/>
        <property type="gene ID" value="CYQ11_08620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="165"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="537" mass="59869" checksum="575A7BE644EE3685" modified="2018-01-31" version="1">MGGSYTPNRPLRGETVTVPPRHGTFSTTGLHSHPSHAQSERMTPLQALNADPFTLGVASGDPLPGSVVLWTRLAPRPFEPGSGLPADGALDVQWELASDESFRHLHRSGTTSAPAEDDHTVHLDVCGLEPDTVYWYRFRVGRWISPVGRTRTAPAPDADVDGVRFGLVSCQQYDEGYYTALAHLAAEDLHAVFFVGDYIYENAINAQAGARNYTDHPLPEFFDHWTWNLTDYRLRYALGKSDPDLQAAHAAHPWFVTWDDHEVENNYAGDVSQNNDPVDVFRARRAAAYRAYWENMPLRAGLRPTGPDMRLYRRFRYGRLAQFDILDTRQYRSDQAYGDGWQYPGPESEDPARTLTGEAQERWLLDGFHDSTALWNVVVQQVAFCRRKNTTADRSRLSMDAWDGYPASRQRVLDGVERAGVENLVVLSGDVHVHYAMDVKKDFDDPGSRTLGVEVVGTSVSSGFDGEERPDDWNLQLAANPHMKYYDGRRGYVVVSLDATRMQADFRTLSGVLTPGAPVQTSARFVSEAGAPGFSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGE1</accession>
    <name>A0A2G1XGE1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22435</name>
        <name evidence="3" type="ORF">CYQ11_08355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50310">
        <property type="protein sequence ID" value="PHQ50310"/>
        <property type="gene ID" value="BLA24_22435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12904">
        <property type="protein sequence ID" value="PPT12904"/>
        <property type="gene ID" value="CYQ11_08355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008535">
        <property type="entry name" value="DUF817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05675">
        <property type="entry name" value="DUF817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009141">
        <property type="entry name" value="UCP009141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="25722" checksum="71CB18AD69F116F7" modified="2018-01-31" version="1">MALLAGVALSSSLAPQLPVARYDLLLGYGLLLTLLFRLCGWETTRDLAVIAVCHAVGLAFELVKVSLGSWSYPEPALFKEAGVPLYGGFLYAAVGSYVCSAWRVLDLELTGYRRRLTAAVAAAVYANFFSHHWLPDLRWPLAALLVAVTTGTWVHYTVGSRRYRMPLALSFALIGFFLWLAENIATYAGAWRYPSQLHGWQPVSVEKFGAWALLISVTVVLVEASRRRQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGK9</accession>
    <name>A0A2G1XGK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19880</name>
        <name evidence="3" type="ORF">CYQ11_10910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50366">
        <property type="protein sequence ID" value="PHQ50366"/>
        <property type="gene ID" value="BLA24_19880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16486">
        <property type="protein sequence ID" value="PPT16486"/>
        <property type="gene ID" value="CYQ11_10910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="369" mass="36795" checksum="73EA771E903934E5" modified="2018-01-31" version="1">MTLPGANLGALRDHNAAVLLGLLRDAGERGASRTELAGRTGLTPQAVSKIAARLRAAGLATEAGRRASTGGKPATALRLVPEAARAIGLHLDRDSVTATLVDLAGTALATRSAPLAFGAGAEAVLDAVAAEVAALPAAPGALLGAGVAAPGPLDHRAGVLHRVTGFPQWDGFPLRDALAARLGLPVVLDKDTNAAALGLVLRAPRDAGSFAYLHLGTGLGAGLVLGGRVHRGARTGAGEFGHQVLRLDGPACPCGRRGCLEALCLRAVADGDTALAARLLGTGAANLVQLLDIDRVLLGGGTVLAGPDPYVHGVRAELPATVPVAVTPAGARTVVEGAAELVLAPLFGRSGHAFALRSDETTISSSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGP6</accession>
    <name>A0A2G1XGP6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50406">
        <property type="protein sequence ID" value="PHQ50406"/>
        <property type="gene ID" value="BLA24_21395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="82" mass="8548" checksum="727F36EB7D624C0A" modified="2018-01-31" version="1">MAPARPHRGGHEGAEDGVVFETSRSATGERCGLAFTSTEALVSRLGPDQPWVALPIGALRHLLGETGISVVAVDPYIPAETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT3</accession>
    <name>A0A2G1XGT3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_16525</name>
        <name evidence="7" type="ORF">CYQ11_16760</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50450">
        <property type="protein sequence ID" value="PHQ50450"/>
        <property type="gene ID" value="BLA24_16525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14295">
        <property type="protein sequence ID" value="PPT14295"/>
        <property type="gene ID" value="CYQ11_16760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="24139" checksum="62A87072915E7EEF" modified="2018-01-31" version="1">MGVIERTWDWLTTGAHWSGTDGVWHRLGEHLFLTAVCLLISCAIALPVAVLLGHVGKGGALAVNISNVGRAVPTFAVLVLLLLSPLGTHGSWPTVIALVLFAIPPLLTNAYVGMREVDRDMIEAARGMGMTGGQVIARVELPLAFPLIVTGVRSAAVQVVATTTLAALAGGGGLGRIITAGFRLTDTAQVVSGALLVAGLALLVEGAFVLLQRLLDPMRRPRPKAAAAPGTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH02</accession>
    <name>A0A2G1XH02_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">BLA24_16935</name>
        <name evidence="14" type="ORF">CYQ11_16345</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50513">
        <property type="protein sequence ID" value="PHQ50513"/>
        <property type="gene ID" value="BLA24_16935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14231">
        <property type="protein sequence ID" value="PPT14231"/>
        <property type="gene ID" value="CYQ11_16345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ50513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="128" mass="14075" checksum="F1420AF3D37A93F3" modified="2018-01-31" version="1">MPLPPWGSPDSGEDGASMGWVTDWSAQAACRTTDPDELFVQGAAQNRAKAVCTGCPVRTECLADALDNRVEFGVWGGMTERERRALLRRRPTVTSWRRLLETARSEYERGAGILPLGDPEYDEYAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH04</accession>
    <name>A0A2G1XH04_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16930</name>
        <name evidence="4" type="ORF">CYQ11_16350</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50512">
        <property type="protein sequence ID" value="PHQ50512"/>
        <property type="gene ID" value="BLA24_16930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14232">
        <property type="protein sequence ID" value="PPT14232"/>
        <property type="gene ID" value="CYQ11_16350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="547" mass="57169" checksum="3D57A82A68BAB338" modified="2018-01-31" version="1">MPVTGTHATAAPRTTTTETAVPPRRTGGNGGSPRPETGAEADKGGSVSLDSAAAPLDIDTVLDNPRTRIVVCCGSGGVGKTTTAAALGVRAAERGRKVVVLTIDPARRLAQSMGIEELDNVPRRVPGVDGSAGGELHAMMLDMKRTFDEIVEAHADKERARAILENPFYQSLSAGFAGTQEYMAMEKLGQLRARDEWDLIVVDTPPSRSALDFLDAPGRLGSFLDGKFIKVLMAPAKIGGRAGMKFLGVGMSMMSGPLNKLMGGQLLRDVQTFVAAMDTMFGGFRTRADATYRLLQAPGTAFLVVAAPESDALREAAYFIERLAAERMPLSGLVLNRVHGSGADRLSAQRALAAAETLTDVAGPPCDYTENLAGSGIVDRGSGQAGSRTADGPGTLAPTDTSSPGAPTVLDIPESGFPQPTHSGATEPGDTEPVVTGSTVAIDPQDPEDAENAEASPDPEASPEGAPEGDSRAPVEAASARLAAGLLRLHAERMQVLAREQRTRDRFTARHPEVPVAQVPALPGDVHDLAGLRAIGERLADQSRPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH79</accession>
    <name>A0A2G1XH79_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Topoisomerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17475</name>
        <name evidence="4" type="ORF">CYQ11_15800</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50593">
        <property type="protein sequence ID" value="PHQ50593"/>
        <property type="gene ID" value="BLA24_17475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14152">
        <property type="protein sequence ID" value="PPT14152"/>
        <property type="gene ID" value="CYQ11_15800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045970">
        <property type="entry name" value="DUF5926"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19348">
        <property type="entry name" value="DUF5926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5926" evidence="2">
        <location>
            <begin position="57"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="34449" checksum="3EBBFD62DC742DCD" modified="2018-01-31" version="1">MAKKRRPQSQAAKPQAGDAPIPVVGAREPCPCGSGRRYKACHGRAASHAAVELVQRPFEGLPGEADWVALRELVPAATVELKLKGGLPEGVPSVRLATVLPMAWPALRRDDGSVLLGLQNDTPTGDLSRDLADTLQRALDAEPGTPIETTRVNADGPRLQDLLDLEGPFEPAVHTGFEFWVDNAENVTGEVAASLERANAAAIPTVRLAGVDAAYWCETPEKNHLRWVMTHPEEQLLDALARLHAARETSLGEGTRLVGSFRAHGLTVPVWDLPGSVRAEDVEKPAAAFAERLAGALADTAPLTPEERRARGGLTSRQVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHC5</accession>
    <name>A0A2G1XHC5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17120</name>
        <name evidence="4" type="ORF">CYQ11_16155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50539">
        <property type="protein sequence ID" value="PHQ50539"/>
        <property type="gene ID" value="BLA24_17120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14207">
        <property type="protein sequence ID" value="PPT14207"/>
        <property type="gene ID" value="CYQ11_16155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="181" mass="20238" checksum="7DDF127F4DDFA39A" modified="2018-01-31" version="1">MSSDEGAARAGPDRPLPENNVAERIKLEREIRGWSTQKLAERMAEVGHPVNQSAIWRIESGKPRRRVNLDEALGFCKVFDIPLDDLASPPGHVSNTEVRRLVGEYVERWKDWRAARKPLDRAKADIDDYIKAHPDQADMVKGLLTYELSGAAGNDFTRYDSVPARHRSLLGDAAPAKPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHP4</accession>
    <name>A0A2G1XHP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_18395</name>
        <name evidence="6" type="ORF">CYQ11_14885</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50750">
        <property type="protein sequence ID" value="PHQ50750"/>
        <property type="gene ID" value="BLA24_18395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13992">
        <property type="protein sequence ID" value="PPT13992"/>
        <property type="gene ID" value="CYQ11_14885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="202"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="319" mass="34055" checksum="2264352277826F45" modified="2018-01-31" version="1">MPAVTVENPLTLPRVTAPADGARRPVLHVATAPSGFEGEGFPVRRAFAGIGYEHLDPFIMMDQMGEVEYAPGEPKGTPWHPHRGFETVTYLIDGTFVHQDSHGGGGTITDGDTQWMTAGSGLLHIEAPPEALVVAGGLFHGLQLWVNLPKKDKMMPPRYQDIGRGKVKLLTSGDGGALLRLIAGELDGHRGPGITHTPVTMAHVSLRPGAEVTLPWRSDFNGLAYALAGRGAAGAERRPFRAGQTVVFGAGDSLTVRADATQESRSPDFEVVLLGGAPIREPMRHYGPFVMNTHAELAQAFEDFQAGRLGVVPADPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHT3</accession>
    <name>A0A2G1XHT3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18025</name>
        <name evidence="3" type="ORF">CYQ11_15250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50689">
        <property type="protein sequence ID" value="PHQ50689"/>
        <property type="gene ID" value="BLA24_18025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14056">
        <property type="protein sequence ID" value="PPT14056"/>
        <property type="gene ID" value="CYQ11_15250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="181" mass="19166" checksum="F6A52F723620FDFF" modified="2018-01-31" version="1">MDAAQQEATARARELQRSWYGEPLGALFRRLIDDLGLNQARLASVLGLSAPMLSQLMSGQRAKIGNPAVVQRVQALQELSSQVADGTVSAAEAAERMEEVKKSSGGSVLNSTQTTASSGAPTVRRVVREIQSLLRSVAGAGDIIEAADTLAPTHPELAEFLRVYGAGRTAEAVAHYEAHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI20</accession>
    <name>A0A2G1XI20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein HesB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03430</name>
        <name evidence="2" type="ORF">BLA24_17235</name>
        <name evidence="4" type="ORF">CYQ11_16040</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000042">
        <property type="protein sequence ID" value="PHQ53108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50875">
        <property type="protein sequence ID" value="PHQ50875"/>
        <property type="gene ID" value="BLA24_17235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53108">
        <property type="protein sequence ID" value="PHQ53108"/>
        <property type="gene ID" value="BLA24_03430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16597">
        <property type="protein sequence ID" value="PPT16597"/>
        <property type="gene ID" value="CYQ11_16040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="21426" checksum="D1059E9A1AE6D694" modified="2018-01-31" version="1">MDHPLRLAQQPEADELLSRSPLAALTGMLLDQQIPMEWAFTGPHTVAARLGRDDLDAQEIAAYDPEAFAALFSEKPAVHRYPGSMAKRVQQLCQYLVEHYGGDASAVWRDAPTGGELLRRLVELPGFGRQKAQIFLALLGKQLGVRPEGWREAAGPYGEEGSFRSVADITGPGSLEKVRAYKQEMKRAAKKAAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIB6</accession>
    <name>A0A2G1XIB6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_17345</name>
        <name evidence="12" type="ORF">CYQ11_15930</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50879">
        <property type="protein sequence ID" value="PHQ50879"/>
        <property type="gene ID" value="BLA24_17345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16593">
        <property type="protein sequence ID" value="PPT16593"/>
        <property type="gene ID" value="CYQ11_15930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="518" mass="53595" checksum="68B0AD286A8A6FEC" modified="2018-01-31" version="1">MVVSTVALVAIVCAVIGTVTTIVLRSYLYGQLDGQLRDVAVRAAAPPGPHGGGLRFVRGGGRPIGTVGAVLGADGRVRDSAVSAPWEPGYGDESLEPLTPAQGAALARLPRDGRPHDVGLPGRGAYRATSVTAPDGTTYLVGIPTTAVRETLSTLVLVEVCVSATALVAAGLAAGAIVRIALRPLRRVASTATRVAQLPLHSGEVALLERVPEAEADPRTEAGQVGAALNRMLGHVGSALAARQESETRVRRFVADASHELRTPLASIRGYAELTRRAGQEPDPATRHALGRIESEARRMTVLVEDLLLLARLDTGRPLAREDVDLPPLVVDAVSDAHAAGPGHTWRLDLPDAPVRVPGDGARLHQVLVNLLANARTHTPAGTTVTARVRPGAACAVVEVEDDGPGVPAALLPHVFERFARGDASRSRAGGGTGLGLAIVRAVVAAHGGAVRVASAPGRTVFTVELPVARGGADDIHSRPTGRPHRDDSAGRQGRVHAPDHPAHRTAVTSPGPWAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIK0</accession>
    <name>A0A2G1XIK0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ORF">BLA24_14850</name>
        <name evidence="14" type="ORF">CYQ11_13220</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004946635.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XIK0"/>
    <dbReference type="EnsemblBacteria" id="PHQ51056">
        <property type="protein sequence ID" value="PHQ51056"/>
        <property type="gene ID" value="BLA24_14850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13721">
        <property type="protein sequence ID" value="PPT13721"/>
        <property type="gene ID" value="CYQ11_13220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="238"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="340" mass="36710" checksum="14E8E351656DACDE" modified="2018-01-31" version="1">MLIAQRPSLTEEVVDEFRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTDLILNIKQLVVSSEHDEPVVMYLRKQGPGLVTAADIAPPAGVEVHNPDLVLATLNAKGKLEMELTVERGRGYVSAVQNKQVGQEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLIVDVETKQAMRPRDAMASAGKTLVELFGLARELNIDAEGIDMGPSPTDAALAADLALPIEELELTVRSYNCLKREGIHSVGELVARSEADLLDIRNFGAKSIDEVKAKLAGMGLALKDSPPGFDPTAAADAFGADDDADAGFVETEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIQ7</accession>
    <name>A0A2G1XIQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15135</name>
        <name evidence="2" type="ORF">CYQ11_12935</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51105">
        <property type="protein sequence ID" value="PHQ51105"/>
        <property type="gene ID" value="BLA24_15135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13671">
        <property type="protein sequence ID" value="PPT13671"/>
        <property type="gene ID" value="CYQ11_12935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="303" mass="31437" checksum="0DB8F21AACADFB8D" modified="2018-01-31" version="1">MESFLGGKVVAVTGAGRGIGRAVALACAAEGAKVVVNDYGVSVQGDQPTSEVATAVAKEIEAAGGEAAAVADDVSTMAGGQRIVDTALARFGRLDGVVCVAGILRERMLFNMTEEEWDPVVATHLKGTFTVFRAASAVMRRQRSGTLIGFTSGNHQGSVAQANYAAAKGGVISLVRSAALGLHKYGVTANCVAPVARTRMSAQVPVELKEIGEPEDVAPLVVYLLSERARQEHITGQVYTVAGPKIAVWAQPRELRAAYADGPWTPQRIADLLPGTVGTDPMPMLGQLQSMASAAAAGERPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIS3</accession>
    <name>A0A2G1XIS3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_15100</name>
        <name evidence="5" type="ORF">CYQ11_12970</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51100">
        <property type="protein sequence ID" value="PHQ51100"/>
        <property type="gene ID" value="BLA24_15100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13677">
        <property type="protein sequence ID" value="PPT13677"/>
        <property type="gene ID" value="CYQ11_12970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="902" mass="93002" checksum="FCCA8A373324046D" modified="2018-01-31" version="1">MDDYAGRVLADRYRLPLPPSEAFDLVETRAFDTYSGQEVLVRQIPLPEVVDAEVLGDERPYGAGPTGPGGRGAGHAGRGNPKAADPAVRRALVAASAAAQVPDHPRLDQVFHVFAEAGSLWIISELVSARPLAALLAERTLSPHRAAEVAADVLTALRALHSQGWTHRNITARTVLICDDGRAILTGLAAGAAEEALCGYDPVPRPVTARGGSAGGTGQGAGPTAPGVSADPGPGKTGGGGPAGGRGAVVPPQTRAGQPGPKATQGGPAVPGSAGRPASKGAYGTVAASGTRGAGVPPQGGPAYRDQGAAGGFALPDVADGREEALNARAVRSGAIAAYHAAARAAAARAAAEAAGLPATGASTWGGGSAASGTAPAPESTPPWNADALVHGPSPAPARTERPGTNGSREPAAKGGGTSSPAVPGAGTPEARKPGTAELAPGSRPVSESWAYTAVPGGALAAERARQARMVVVGAVTERWAPEQAWPVQENWQLAPPVGPAADLWALGALLFRVVQGHAPYPEDSTAELVQVVCAEPPAYAEECGALRPVVESLMRKDPSERPEFEELRGWLRSLIRSAPEPDIGSRTVTVPSIGAPVPADGRRLPVIRRRGELVRRRRGRTSTASAEPAAAVHGRHKRTAKETLKAGQAGERSAFHSTGHLQEQRVRTAPAPHRLGRLLLGVILLALIGAVLYALLFMPRAEQDEGRTPSDHTGAAGALSAAPDRPGGGGSMGRTSASGIQGDPTEETTGTAKGFTLRKDPKGFMVAVAANWQRRGENERGQVVYVGGDYELIVVPGRDKVSEFGGDPMTYQQEKEPELAPYRSSTWSGASGLRRIDVGGTATAEGTFNWNDSSGRQVYVRNAAMILGGRYHLLLVRGPMDEQRSVDAFFEQATATYRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIU9</accession>
    <name>A0A2G1XIU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15550</name>
        <name evidence="3" type="ORF">CYQ11_12525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51172">
        <property type="protein sequence ID" value="PHQ51172"/>
        <property type="gene ID" value="BLA24_15550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13604">
        <property type="protein sequence ID" value="PPT13604"/>
        <property type="gene ID" value="CYQ11_12525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="59" mass="6412" checksum="FDF8D0BBB11EDC03" modified="2018-01-31" version="1">MSTLPEPAPRRKPTALIFDDPLSQQSSDDTDRGWGDRPSGGGSAADLARFLDEKPPHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIV5</accession>
    <name>A0A2G1XIV5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15505</name>
        <name evidence="3" type="ORF">CYQ11_12570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51166">
        <property type="protein sequence ID" value="PHQ51166"/>
        <property type="gene ID" value="BLA24_15505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13611">
        <property type="protein sequence ID" value="PPT13611"/>
        <property type="gene ID" value="CYQ11_12570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="183" mass="20129" checksum="A908E0F16704D124" modified="2018-01-31" version="1">MKPMDVQVRPGGEEDLDALTEIYNHYVRETAITFDVTPFTPEERRRWLLSYSQDGPYRLLVAREGGEGPEGRVLGYATSSPFRAKAAYRTSVEVSVYCAPAARGRGVGTLLYEALFAALEGEDVHRAYAGVTEPNPASARLHRRFGFAPVGTFREVGRKFGRYWDVTHYERPVGGVGAAPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIW4</accession>
    <name>A0A2G1XIW4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15490</name>
        <name evidence="3" type="ORF">CYQ11_12585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51163">
        <property type="protein sequence ID" value="PHQ51163"/>
        <property type="gene ID" value="BLA24_15490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13614">
        <property type="protein sequence ID" value="PPT13614"/>
        <property type="gene ID" value="CYQ11_12585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="19509" checksum="6E06A1CB5BBB084D" modified="2018-01-31" version="1">MTNRPAGGPEAAEAAAEPRWLTDEEQGTWQAYLHASTLLEDYLDRQLQRDAGMPHVYYGLLVQLSEAPRRRMRMTELAQQAKITRSRLSHAVARLEKNGWVRREECPSDKRGQLAVLTDEGFAMLRASAPGHVAAVRAAIFDRLTPEQARRFGDMCRTIATGLEPAGADLPWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJA5</accession>
    <name>A0A2G1XJA5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uma2 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14235</name>
        <name evidence="3" type="ORF">CYQ11_13840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51332">
        <property type="protein sequence ID" value="PHQ51332"/>
        <property type="gene ID" value="BLA24_14235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13828">
        <property type="protein sequence ID" value="PPT13828"/>
        <property type="gene ID" value="CYQ11_13840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="201" mass="22895" checksum="0848C9DB7C73A73C" modified="2018-01-31" version="1">MAIGRPGQPATADNWMFPPGDGWTFDQVKELELPWDWELVDGAIVVRGQTKLWHDIVRDNLHRQLQLAAPSPYGVNVERCVMLTEDNVRKPDVVVYDTTNLDIFTAECTPASEVKLAVEVVSPGSRSDDRFRKPALFAEANVPCYWRIELEQDRRLAVHEFWLPVGEQSYIPAPLHPVHREKLVTDLPFSLEIDLTALLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD1</accession>
    <name>A0A2G1XJD1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16355</name>
        <name evidence="3" type="ORF">CYQ11_11720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51310">
        <property type="protein sequence ID" value="PHQ51310"/>
        <property type="gene ID" value="BLA24_16355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13464">
        <property type="protein sequence ID" value="PPT13464"/>
        <property type="gene ID" value="CYQ11_11720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="360" mass="37379" checksum="78BD8FA3B9958FC5" modified="2018-01-31" version="1">MTEAILLVGGKGTRLRPLTVHTPKPMVPAAGVPFLTHQLARARAAGVEHIVLATSYLAEVFEPYFGDGSALGLHLEYVTEEEPLGTGGAIRNVASRLRSAPGDPVLIFNGDILTGLDIEALVETHRTSGADVSLHLSRVEDPRAFGLVPTDATGRVTAFLEKPQTPEEIVTDQINAGAYVFNRSVIDTIPTGRPVSVERETFPGLLADGAHLQGMVDSTYWLDLGTPQAFVRGSADLVLGRAPSPAVPGRCGDSLVLDGAEVAPDAKLMGGTAVGAGARVEPGARVDGSTVLDGAVIEAGAQVRDSLIGAGARIGARTVLDGAVIGDNAHIGPDNELRGGARVWCDARIPAGSIRFSSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJE4</accession>
    <name>A0A2G1XJE4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ppx/GppA family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16035</name>
        <name evidence="3" type="ORF">CYQ11_12040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51259">
        <property type="protein sequence ID" value="PHQ51259"/>
        <property type="gene ID" value="BLA24_16035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13515">
        <property type="protein sequence ID" value="PPT13515"/>
        <property type="gene ID" value="CYQ11_12040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="317" mass="33960" checksum="CCA1DABF55B34361" modified="2018-01-31" version="1">MTRVAAVDCGTNSIRLLVADVEPATGELKELDRRMTIVRLGQGVDRTGRLAPEALERTFAACREYAEVIKAHGAERVRFVATSASRDAENREEFVRGVVEILGVEPEVVTGDQEAEFSFAGATRELAGRDDLDKPFLVVDIGGGSTEFVVGAEHVRAARSVDVGCVRMTERHLVVDGKVTDPPSEAQLAAIRGDVEAALDLAEETVPLTEARTLVGLAGSVTTVAAIALGLEEYDSAAIHHARISLDRVREITAGLISSTHEQRAQIGPMHPGRVDVICAGALILQCVMERMGAREVVVSEHDILDGIAFYAALDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK6</accession>
    <name>A0A2G1XJK6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_04460</name>
        <name evidence="6" type="ORF">BLA24_14025</name>
        <name evidence="8" type="ORF">CYQ11_01720</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51444">
        <property type="protein sequence ID" value="PHQ51444"/>
        <property type="gene ID" value="BLA24_14025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52836">
        <property type="protein sequence ID" value="PHQ52836"/>
        <property type="gene ID" value="BLA24_04460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11785">
        <property type="protein sequence ID" value="PPT11785"/>
        <property type="gene ID" value="CYQ11_01720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="40"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="373" mass="41822" checksum="BD4F6EAD3A70E5EA" modified="2018-01-31" version="1">MAIPVTITQRPPSRREVKERTAALLADRPDLAERLHRVRRQGRTVRSCEVHLTNACNIRCKGCWYFEGGFDTAVKELSDLGRIRAFARRLRDEGVNQATLIGGEPTLVPRRVEAFMEELPYITISTNGLRPMPKEGFEDIAIAVSIFGGGPLDDDLRAIRVNGSTFTGLFDTALGHYRDDPRVMFIFALAEAGVPHLEPTVRKIAENGNIVTFNFYSEHGSDNPIRIENERRVLDEALRVKELYPETVVSHPYFIRTLITGASHWGGRFGYDVCPSLSVDHPAHADRVANGNPVIPGFAAWGADYETLQFCCTSGDCNGCRDSQAVYSWLVVSASRFLDSAERLEEWLDIAESYWRQWYWSPYHASRAGAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJM7</accession>
    <name>A0A2G1XJM7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13965</name>
        <name evidence="2" type="ORF">CYQ11_01660</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51433">
        <property type="protein sequence ID" value="PHQ51433"/>
        <property type="gene ID" value="BLA24_13965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11774">
        <property type="protein sequence ID" value="PPT11774"/>
        <property type="gene ID" value="CYQ11_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="357" mass="38502" checksum="95A4F853587E3EEB" modified="2018-01-31" version="1">MNVHDMKVQQILRRACELDRGRFAVGIEIQPYKLAGVVVGSDGAVIARSRRHLTVMESAEVVRHVAEMVGTLVDDRLGCAFPRSRVCLGVQVGGPVDPDTGTVLHLINGPDDHSHEKPPPYEWVDFPLAEELMAATGYRTSVENDAHAFAAYEQSMGVGRRSKTFGVILVRDGVGAGMVVRGERLSVPLEFGHIQVWHRGRVCDCGMRGCIESQVGNRALTAVVRERTGRALDGLEAAIALADGDDPQAREAATAFRKAGTSLSRGIATLLTTFGPSHVVIYAAGGLIDGGPGRRAANAFLHAMRKFPAHTFQISRDCQLVTKPLDAVRGAHGAALIAQQSCFDGRHHDQGDRHHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJV4</accession>
    <name>A0A2G1XJV4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13530</name>
        <name evidence="3" type="ORF">CYQ11_01250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51522">
        <property type="protein sequence ID" value="PHQ51522"/>
        <property type="gene ID" value="BLA24_13530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11705">
        <property type="protein sequence ID" value="PPT11705"/>
        <property type="gene ID" value="CYQ11_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="15692" checksum="EF2D7CF99A5B6027" modified="2018-01-31" version="1">MPDRDESLEIIQRELTAFARRARAAAARLHPELSLVSYALLAHLEDSDGCRPSALAEQFLLNKSTISRQVTTLEELGLVERRTDPGDQRAHILHLTAGGRAALGQVSDHRRAAFQERLADWTAEDLARFAGYLLRYNDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK37</accession>
    <name>A0A2G1XK37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YbjN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13035</name>
        <name evidence="2" type="ORF">CYQ11_17395</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51614">
        <property type="protein sequence ID" value="PHQ51614"/>
        <property type="gene ID" value="BLA24_13035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14407">
        <property type="protein sequence ID" value="PPT14407"/>
        <property type="gene ID" value="CYQ11_17395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18569" checksum="8350EA31621DA69E" modified="2018-01-31" version="1">MSDAKTTIERTLREADLEWESPAEGTYVVKLPGTRKLSTTVSLVLGKHSLSVNAFVVRRPDENHEAVHRWLLERNTKLYGLAYAVDRLGDVYLVGRLPLVAVTPEEIDRVLGTVLEHADGSFNTLLEMGFATAIRKEYAWRTARGESTRNLEAFARLTREEGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKA0</accession>
    <name>A0A2G1XKA0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12575</name>
        <name evidence="4" type="ORF">CYQ11_17460</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51665">
        <property type="protein sequence ID" value="PHQ51665"/>
        <property type="gene ID" value="BLA24_12575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16625">
        <property type="protein sequence ID" value="PPT16625"/>
        <property type="gene ID" value="CYQ11_17460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="395" mass="43586" checksum="55A17BCDDB8E898D" modified="2018-01-31" version="1">MVVAYHYVAFGSGAWGRPAPELFPVAHLPASYGWLGVQLFFLISGFVICMSGWGRSLGDFAVARATRLYPAYWFAVLTVALVIRLDPVGGDAPGLTDVALNLTMLEHPLGVDPVDGVYWTLWAEARFYLLFALVVWKGLSYRRAVAFCLLWGCAAVTTRACHDDLLAQLLMPRDCWYFIAGVAFYLMYRFRPAPALWLIVGGCLLIAQHDLLRSRARAQTYMGYAVPHWPACALVTLFFLAVAAIALGWTRRVRGRWLTAAGALTYPLYLLHERLGWLVIGHLGGRLPRWLLLSGLVTGMVLAAWVVHCCVERPLARRLGHALRRAVADMRSVSSGQARVSAGQTEIRPCQTKESRACETPVTAPAARGVSACGGLHTMSRLSQREPTQSQERTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKR2</accession>
    <name>A0A2G1XKR2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12170</name>
        <name evidence="5" type="ORF">CYQ11_03410</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51828">
        <property type="protein sequence ID" value="PHQ51828"/>
        <property type="gene ID" value="BLA24_12170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12075">
        <property type="protein sequence ID" value="PPT12075"/>
        <property type="gene ID" value="CYQ11_03410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="30055" checksum="4880E8628C114E72" modified="2018-01-31" version="1">MDRLTGFGGGGGDAVERSRTGAETGGHAPGGGSAGGGATARAAWLRTPRPRPGAAWQLFCLPYAGAILTPYGDWGRRLGPGVEVSCVELPGRGARSAEPPQRSVDRIVAGLAGPLLDAVRGPYALFGHSFGALLAFELSHALTGLGRPPGRLIVSGCVPPCVPRGSRRLHDLPDDRLLEYAVELAGAPTRALRAFMLPTLPLLRADLEAFDTYAYAERPALTTPLTAVRGEADRFVPAGSLPRWGELTTGPFRTGTLPGGHMYLREQTGPLLSVVREDLEGAPGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKV8</accession>
    <name>A0A2G1XKV8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12050</name>
        <name evidence="3" type="ORF">CYQ11_03290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51860">
        <property type="protein sequence ID" value="PHQ51860"/>
        <property type="gene ID" value="BLA24_12050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16324">
        <property type="protein sequence ID" value="PPT16324"/>
        <property type="gene ID" value="CYQ11_03290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304714" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="17919" checksum="9140048B5CCCB0BD" modified="2018-01-31" version="1">MLLTLTTALVAQLGPAAAVAEAQQVSATAGSTRPVGTVRITEGQVAEAAPGGTILYPSVTSCLTVTVRLRGGAKVGAHASLFQVPGAYRSDEILAAVKRRVGARAVTAVEVRGAVGAWHPGYFTRAVESYPEGEPVPVPTEADPQGLARAVAEGLGLPPSVRVSVEDVPDGDQTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL81</accession>
    <name>A0A2G1XL81_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000115">
        <property type="protein sequence ID" value="PHQ51995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51995">
        <property type="protein sequence ID" value="PHQ51995"/>
        <property type="gene ID" value="BLA24_10300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="94" mass="10972" checksum="F9653FB3797075DD" modified="2018-01-31" version="1">MRFRARTTVRTGCLLWNGTRASGPARPPAWTANLLAHPDVEINWRGRDIPVRARLLSGAEREGAWATALAFWPPYARYQERVEREIRLFRLDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLI2</accession>
    <name>A0A2G1XLI2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09120</name>
        <name evidence="3" type="ORF">CYQ11_27730</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52077">
        <property type="protein sequence ID" value="PHQ52077"/>
        <property type="gene ID" value="BLA24_09120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16157">
        <property type="protein sequence ID" value="PPT16157"/>
        <property type="gene ID" value="CYQ11_27730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="31830" checksum="E037E8E782C2D061" modified="2018-01-31" version="1">MRYGPAVRRRKLGAELRRQRELSGMTSREAACAVGWHQSKVSRIETGISGVKPADVARLLDVYSVFDPDLRALLGALCGADPAGSGSGGGSRRGWWYAYRDLLPSAYLDFISLESEASHARTLETTVVPGLLQTPEYARAVTRAALGDPPAEQVEALVRVRMARQSVLAKERPLELCAMLDEAALRHEVGGPEVMAGQLEHLLERAALPHVRLHVLPFSSGDHIGITGPFVIFSFPRIADLDVVVLDHLTSSLYLERQEDLRAYGSAFTTLRAHALSHENSLDFIAGIKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM3</accession>
    <name>A0A2G1XLM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AMP-dependent synthetase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phenylacetate--CoA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09530</name>
        <name evidence="2" type="ORF">CYQ11_28140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52148">
        <property type="protein sequence ID" value="PHQ52148"/>
        <property type="gene ID" value="BLA24_09530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16229">
        <property type="protein sequence ID" value="PPT16229"/>
        <property type="gene ID" value="CYQ11_28140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="423" mass="45945" checksum="DC48E1525971CE2C" modified="2018-01-31" version="1">MPVHQLSDLIRYSRHNSPFYSALYAHLPPEADRLADLPVVDQDAFWKANTLHGNRVLTGPLAEAVVYKTGGTTGAPKFSCYTREEWREFVTAFGQGLVEAGLRPGHRVADLFYAGELYASFLFVLDSLAHAPVDNVRLPIGGGAPLETTVPTLEDFAAEVVAGTPTTLCRLAEHVIATGRQLPSVELLFFGGEALFDDQRRLLAAAFPHAEARSLGYASVDAGLLGRPVPGPDPRVHRAFTPHTVVEILDETTGEVIDEPGRPGRVVVTQLYRKLMPVIRYPAGDRAEWADPEAGHFRILGRAEEGVRVGPVSLYSQDALDAVAEADTEGRITGTQLVVRRWDGRDGLVLRLATAPGDDDPAGLEVLAKAVVTELDEARPLYPDSVRAGHVHPLAVEWARHGDLVVNPRSGKLVRVIDERPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLP8</accession>
    <name>A0A2G1XLP8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000095">
        <property type="protein sequence ID" value="PHQ52194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52194">
        <property type="protein sequence ID" value="PHQ52194"/>
        <property type="gene ID" value="BLA24_09025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="64" mass="7090" checksum="74018A810162C44E" modified="2018-01-31" version="1" fragment="single">MVQRYEPRTHRWIDLDASTGGGSWPDRGVYTFPVTAADASPRHPRTVALRLQDLDRPGTVTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLT8</accession>
    <name>A0A2G1XLT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_09245</name>
        <name evidence="5" type="ORF">CYQ11_27855</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52099">
        <property type="protein sequence ID" value="PHQ52099"/>
        <property type="gene ID" value="BLA24_09245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16179">
        <property type="protein sequence ID" value="PPT16179"/>
        <property type="gene ID" value="CYQ11_27855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="29"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="28471" checksum="1DAD2EBCA92EA531" modified="2018-01-31" version="1">MTDNFSGADDNGLWIRRFHPRPDSAVRLVCLPHAGGSASFYFPVSRAMPDFADVLCVQYPGRQDRRAEPLVDNIPDLADQVYAALLPWADRPLALFGHSMGASLAFEVARRLERDKGIVPAYLFASGRRAPSTHRDERVHLQDDNGLIAEMRRLSGTSTQLLGDEEVLRMILPAIRSDYRAAETYAYEPGEPLTCPVLGLVGDDDPKVNLDEAAAWAGHTEGSFDLKVFKGGHFYLAEHQAAVIKEMADRLRPLAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLX1</accession>
    <name>A0A2G1XLX1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipase maturation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_08750</name>
        <name evidence="8" type="ORF">CYQ11_04010</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52242">
        <property type="protein sequence ID" value="PHQ52242"/>
        <property type="gene ID" value="BLA24_08750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12175">
        <property type="protein sequence ID" value="PPT12175"/>
        <property type="gene ID" value="CYQ11_04010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="PTHR14463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="475" mass="54054" checksum="EBE70176D68A11A9" modified="2018-01-31" version="1">MEWFTASGYWLSRLVLQRALAGVYLVGFLSAALQFRALMGERGMLPVPRFVAYVPLRKAPSVFHFHYSDRFFAAWSWGGALLSAAMLAGAADAVPLWAAMVMWAALWALYLSIVNVGQTWYGFGWESLLLETGFLAVFLGNARTDPPVLVLWLLRWLLFRVEFGAGLIKLRGDSCWRDLTCLYYHHETQPMPGPLSWFFHRLPRPLHRVEVAANHVAQLVVPFGLFLPQPVAGVAAGLIICTQLWLIASGNFSWLNWITIVLAFAAVDGEAAAELFSLPGHAPLPAAPYWFVGLVCAATALVLVLSWWPARNLISPQQRMNMSFNAFHLVNTYGAFGSVNRTRYEVVVEGTDEESVGPDTAWREYGFKGKPGDPRRLPRQYAPYHLRLDWLMWFAGISPGYAREWFGPLVERLLTNDPATLRLLRHNPFPEAPPTYVRAQLYRYRFTTWRELRETGAWWHRTLEREYLPPARLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM83</accession>
    <name>A0A2G1XM83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08665</name>
        <name evidence="3" type="ORF">CYQ11_03920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52281">
        <property type="protein sequence ID" value="PHQ52281"/>
        <property type="gene ID" value="BLA24_08665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16336">
        <property type="protein sequence ID" value="PPT16336"/>
        <property type="gene ID" value="CYQ11_03920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="168" mass="17643" checksum="E1CE3D574F0C8FE3" modified="2018-01-31" version="1">MTASPELGTPHLTTPDLLRSVFRRHAAGVAVITAHGTRPVGFTATSVTSVAAEPPLLSFGVGTGSSSWPVLSEAEHVGVHILGEHQQELAATFARSGADRFAPPTRWRTGPHGVPVLEGVLAWTVCRVVARVPAGDHRVVLAEVVAGDPTGAGRPLLYHQGRFNGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM84</accession>
    <name>A0A2G1XM84_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmE2</name>
        <name evidence="5" type="ORF">BLA24_07795</name>
        <name evidence="6" type="ORF">CYQ11_00225</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52347">
        <property type="protein sequence ID" value="PHQ52347"/>
        <property type="gene ID" value="BLA24_07795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11550">
        <property type="protein sequence ID" value="PPT11550"/>
        <property type="gene ID" value="CYQ11_00225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="81" mass="8999" checksum="53C5FEAEC507ADC1" modified="2018-01-31" version="1">MKPGIHPAYGPVVFRDSASGTAFLTRSTMTSDKTIDWEDGNTYPVVDVEISSASHPFYTGTARVLDTAGRVERFERRYGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XML0</accession>
    <name>A0A2G1XML0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_06565</name>
        <name evidence="6" type="ORF">CYQ11_26715</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52443">
        <property type="protein sequence ID" value="PHQ52443"/>
        <property type="gene ID" value="BLA24_06565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15975">
        <property type="protein sequence ID" value="PPT15975"/>
        <property type="gene ID" value="CYQ11_26715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="30977" checksum="A3AAC860C20C5345" modified="2018-01-31" version="1">MSDGSAVRVRDLRKAYGHRTVLDGVDLDVGRGEVVAVLGPNGAGKTTLTEILEGYRGRDGGEVTVLGEDPGTAGPDWRDRIGIVLQGNGDLAHLTPREAFRHFAGYYSTPRDPDELLAVVGLVEQAGKRIGKLSGGQRRRVDVGLSMLGDPELIFLDEPTTGFDPEARRRFWDTVRSLRASGTSVLLTTHYLDEAEALADQVAVLAHGRVVAAAPPAELGGAGRRRPVVHWRENGTPRQETTDDPSAVVQRLTRELGGSVPDLRVESPSLEDVYLDMISDDRSEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMS6</accession>
    <name>A0A2G1XMS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07180</name>
        <name evidence="3" type="ORF">CYQ11_27335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52547">
        <property type="protein sequence ID" value="PHQ52547"/>
        <property type="gene ID" value="BLA24_07180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16085">
        <property type="protein sequence ID" value="PPT16085"/>
        <property type="gene ID" value="CYQ11_27335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305610" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="82" mass="7898" checksum="F743F09886A7A05A" modified="2018-01-31" version="1">MTAVVAVAGAALGAFLVMGHKADGKPVKNDSTIGPVSAAPSFSLPSGLPSSLPSSLPSGFPSGLPTSLPSLPAGLPTGWPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMS9</accession>
    <name>A0A2G1XMS9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07060</name>
        <name evidence="2" type="ORF">CYQ11_27215</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52526">
        <property type="protein sequence ID" value="PHQ52526"/>
        <property type="gene ID" value="BLA24_07060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16063">
        <property type="protein sequence ID" value="PPT16063"/>
        <property type="gene ID" value="CYQ11_27215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="29120" checksum="BA40BAD7DDBA6820" modified="2018-01-31" version="1">MSGAPGPRGATGARAAEATGAPAAGCLRGRVALVTGGTRGVGAGVARAMLRAGARVLVCARRPPDAPVTAAGRTARHLPVDLREPAAVRDLFAHLQETEGRLDVLVNNAGGTPFRPLGAADAERHARVLELNLTAPLTASLAAHRIMRDQPSGGAIVMIGSVSGTRPSPGTAAYGAAKAGLENLARTMAVEWAPAVRVNTLVLGMVRTESAHLHYGDRDGVAAVARTVPAGRLAEPDEVGEAAVFLASDRAAYITGASLLVHGGGERPAFLDAADANRPVDLDQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX1</accession>
    <name>A0A2G1XMX1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_07210</name>
        <name evidence="9" type="ORF">CYQ11_27365</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52553">
        <property type="protein sequence ID" value="PHQ52553"/>
        <property type="gene ID" value="BLA24_07210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16091">
        <property type="protein sequence ID" value="PPT16091"/>
        <property type="gene ID" value="CYQ11_27365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="31"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="424" mass="42866" checksum="E3E3220FB892F905" modified="2018-01-31" version="1">MYLTDGRAAPPTAAPGRDSAPGRRAAVVPGTVLVLGTVSLVTDVSSEMVSAVLPLYLVTGLGLSPLGFGLLDGVYNGVSALVRLVGGRLSDRSGHKAVAAVGYGLSAVCKPLLLAVHSLPLIGAVLAADRTGKGLRTAPRDALISLSCEPAGRGRAFGVHRAMDTAGALLGPLVAFLILRAAADGYDAVFTASGCVAALGVLVLLLFVPGRTRGPSAARPPASRAPMRELLRRPAVRRLTGCAVVLGLTTVSDSFLYLTLQRRLTLSESWFPLLPLGTAGTFLLLAVPLGAVADRIGRRRLFLCGHLALLGAYGLLVAPLGDSPALACLVLALHGSFYAATDGVLAAATADAVPAAVRGTGLAVVQTGQAAARFVCSIAFGAAWTAWGDRTALGAAAVGLAVAAAAGALLLRPAPPEPTPEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN08</accession>
    <name>A0A2G1XN08_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07440</name>
        <name evidence="3" type="ORF">CYQ11_27590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52593">
        <property type="protein sequence ID" value="PHQ52593"/>
        <property type="gene ID" value="BLA24_07440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16130">
        <property type="protein sequence ID" value="PPT16130"/>
        <property type="gene ID" value="CYQ11_27590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="138" mass="15059" checksum="D05CF394BC3E4B43" modified="2018-01-31" version="1">MYAEPGIIRKIIEGTGDTWAVVGLSSNRQRAAHGVAEFLQRHGKRVVPVHPKAETVLGERGYASLAEIPFPVDVVDVFVRSELAGPVADEAVRIGAKAVWFQLGVIDEDAYDRTRAAGALMVMDRCPAIEIPRLARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN71</accession>
    <name>A0A2G1XN71_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07470</name>
        <name evidence="2" type="ORF">CYQ11_27620</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52599">
        <property type="protein sequence ID" value="PHQ52599"/>
        <property type="gene ID" value="BLA24_07470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16136">
        <property type="protein sequence ID" value="PPT16136"/>
        <property type="gene ID" value="CYQ11_27620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="561" mass="61976" checksum="C07BCC0CD9EEF944" modified="2018-01-31" version="1">MPNTTSAPLPRQVADSYVDAYVRLDPITGTFLGIAECARRLPDYSPAGERAVADLARATLAALTEAERRPGADSADERRCARLLRERLTARLAVHEADEHLRAVSNMESPLHSVREVFALMPTETAEDWSAITDRLHAVPAALEGYRASLAEGLEKKLPAGPRQVATVLVQLGEWIGTGNGWFGDFTAQGPQELRAGLDAGAAAARGALVALRDWLRDVYAPAVEGAPDVVGRERYALWSRYWNGTDLDLREAYAYGWSEYHRLIGEMRTEAEKILPGAATPWEALAHLDVHGEHIEGVEEVRVWLQKLMDDSIEALDGTHFELAERVKRVESHIAPAGGAAAPYYTEPSEDFSRPGRTWLPTMGQTRFPVYDLVSTWYHEGVPGHHLQLAQWMHVADRLSRYQAGVGIVSANCEGWALYAERLMDELGFLTDPERRLGYLDAQMMRATRVIIDIGMHLELEIPAHSPFHPGERWTPELAQEFFGLHSGRPADYVESELVRYLGMPAQAIGYKLGERAWLAGREAARAAHGDAFDAKAWHMAALSLGSLGLDDLVAELSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNF7</accession>
    <name>A0A2G1XNF7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1707 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05835</name>
        <name evidence="4" type="ORF">CYQ11_02310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52782">
        <property type="protein sequence ID" value="PHQ52782"/>
        <property type="gene ID" value="BLA24_05835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11884">
        <property type="protein sequence ID" value="PPT11884"/>
        <property type="gene ID" value="CYQ11_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="181" mass="20198" checksum="8282B65632F6A7CE" modified="2018-01-31" version="1">MTTSPDFRTRVARPSEAERNQALEILRDGAGDGRLSHDTFIRRMNIVLTARNRAEIDQVMADLPARGRLSDVVLRAVARVAMLPVRVRRAWNTARLPGLRLPEPGTGPLHIGRSPLADLRFEDDTVSRRHAELRFLDDDWRLSDLGSRNGTYVNGLRIAGTVRVRPGDHVAFGSLGFRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN6</accession>
    <name>A0A2G1XNN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5133 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05905</name>
        <name evidence="3" type="ORF">CYQ11_02380</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52830">
        <property type="protein sequence ID" value="PHQ52830"/>
        <property type="gene ID" value="BLA24_05905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16305">
        <property type="protein sequence ID" value="PPT16305"/>
        <property type="gene ID" value="CYQ11_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033457">
        <property type="entry name" value="DUF5133"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17196">
        <property type="entry name" value="DUF5133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="95" mass="10081" checksum="A4BA7AD2F6D6AEC8" modified="2018-01-31" version="1">MLLAHPAVLHDLVERYTALERAVTSGSADPVTRQRLADTAYTLCVSTGTRDIDAALIAARHRLPGARVEDDSVLSPRTPVRAGARTDGPAPVPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN9</accession>
    <name>A0A2G1XNN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000071">
        <property type="protein sequence ID" value="PHQ52833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52833">
        <property type="protein sequence ID" value="PHQ52833"/>
        <property type="gene ID" value="BLA24_05295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="183" mass="18643" checksum="381D0F0FA4AE5295" modified="2018-01-31" version="1">MLSGSWLIVAEGELGQRIGTALSGRATDVQVWTPAQWDRQTVASGVAAFGELDGVVCVAGMAGSLAVTQGLGDAGVEAPLWLVTSGAVSTGAGDVLRDAAAAAVWGYGRVVGLEHPERWGGLVDVPEELDERAVARLAGVLAGSGEDQVAVRAAGVFGRRLMRAALADTPVAGRRGARRAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR9</accession>
    <name>A0A2G1XNR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05875</name>
        <name evidence="4" type="ORF">CYQ11_02350</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52789">
        <property type="protein sequence ID" value="PHQ52789"/>
        <property type="gene ID" value="BLA24_05875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11891">
        <property type="protein sequence ID" value="PPT11891"/>
        <property type="gene ID" value="CYQ11_02350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="293" mass="30885" checksum="3A3223C541EC2985" modified="2018-01-31" version="1">MPLNLPQLRAFVAVVDAGGFGTAATDLGLSQSAVSHAVASLERILAGPLLVRSTPVRTTALGERVLPHARAAVSATDALRDAAARHGSEVSGTVRLASTPTVCQGLLPALQRHWSAHLPGVRVRVFEGSSDEAVTWLENGAADAVIVADPPSGAGTPLVTDPFLALLPQDHPLARENAVHVSDLEDDPLILSPNGCERHVHRIHRAAGTPFSPAHRVRDLGTLISMVQAGMGISILPRVSRPLLPTDLVLVPVEPRYCRRLVLCGPEGRPWSPAVRALADSVETLPRAVLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPE0</accession>
    <name>A0A2G1XPE0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ppx/GppA family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03330</name>
        <name evidence="3" type="ORF">CYQ11_16960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53115">
        <property type="protein sequence ID" value="PHQ53115"/>
        <property type="gene ID" value="BLA24_03330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14333">
        <property type="protein sequence ID" value="PPT14333"/>
        <property type="gene ID" value="CYQ11_16960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="32758" checksum="8B92214909B8D63E" modified="2018-01-31" version="1">MRLGVLDVGSNTVHLLVVDAHPGARPLPAHSHKAELRLAELLDDDGAISDAGIDRLVAVIGDALQAAEDKGVEEVLPFATSAVREAANADAVLTRVQRETGVTLPVLTGAEEARLTFLAARRWFGWSAGKLLVLDIGGGSLEIAYGLDEEPDAAASLPLGAGRLTASWLPGDPPAPADVRALRRHVRAEIARTVGDFARLGTPDHTVATSKTFKQLARIAGAARSGEGLYVQRNLSRKALEEWVPKLSAMTSDRRASLPGVSAGRAAQLLAGALVAEAAMDLFGVEELEICPWALREGVILRRLDHLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPN4</accession>
    <name>A0A2G1XPN4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4291 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02310</name>
        <name evidence="3" type="ORF">CYQ11_04675</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53192">
        <property type="protein sequence ID" value="PHQ53192"/>
        <property type="gene ID" value="BLA24_02310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12284">
        <property type="protein sequence ID" value="PPT12284"/>
        <property type="gene ID" value="CYQ11_04675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="230" mass="25876" checksum="4EF6EE7BED1A6262" modified="2018-01-31" version="1">MGRVNNPIHPAAGTRPAPATHPTPAIPPADAAGPALPARQIRARHTDSTITVYQAYTPGIGVPAARDGRFPASWKRDRMTWIKPSFLWMMYRCGWGTKEGQETVLAVEISREGFEWALDHSCLSHYDRRIHPDETAWKRQLKRSPARVQWDPERDLRLNPLPHRSLQLGLAGDASRRYADEWTVGITDVTALAAEVHRRVREGDLDGAASLLPDERPYPLDDARLAHLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPN6</accession>
    <name>A0A2G1XPN6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02060</name>
        <name evidence="2" type="ORF">CYQ11_04425</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53151">
        <property type="protein sequence ID" value="PHQ53151"/>
        <property type="gene ID" value="BLA24_02060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12241">
        <property type="protein sequence ID" value="PPT12241"/>
        <property type="gene ID" value="CYQ11_04425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="474" mass="52515" checksum="3F448DC8DBDA7EFE" modified="2018-01-31" version="1">MTWTSQTFGGEARTDAAIRTALPTASRSENLRLTLLYFLPNYLKGVFRARPRVGRLVARLDPGRHGAETMRRLRRRHGRGPVVVRGTSGPTLLVLDAEDARQVLSGPVEVYAVDTWEKVSGFAAVQPEALVASHGRQRTARRAFNDAVLDAGLPVHRLAGHFLRVVGEESRALLGPEAEAGLTAGQIRERVERVGRRCFLGEAAADDEEFSRLLGELLAEANWMGARRWRAARTRRLRRRMMQRQARYLCDADPRSLTGLFRTAPRGPETAPEGQVAHWFMALGVVHAAVVQTLSLLATHPRHHARAVREVREADRRHGAHTVAGFEAMDYVRACVQDAVRLWPPVPSLMRRTTAETRWRTAVAPGGVNVLVPAAFHARDEERIDYAHRFAPQKWLDGTAGEDWAVSPFSRGEARCSGTELGILLATGFVAEFLRGGELAVAGVRLDPGRPLPHGFDATRLRIGYRPCPAPEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPS8</accession>
    <name>A0A2G1XPS8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_02615</name>
        <name evidence="4" type="ORF">CYQ11_04910</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53226">
        <property type="protein sequence ID" value="PHQ53226"/>
        <property type="gene ID" value="BLA24_02615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12318">
        <property type="protein sequence ID" value="PPT12318"/>
        <property type="gene ID" value="CYQ11_04910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="864"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="934" mass="99441" checksum="BD2535CB7F795216" modified="2018-01-31" version="1">MTVNLFERDAEMGVLREAFAAAVQGRGETIILSGVIGAGKTALLHEFNEFAAESGGLVLASACGPAEQELPLGLMEQLFRDAPLSEENSRRVHDVLREASALTPPLSDALTPSGARMIRGLCTALLDLADSRPVVVSVDDVQSADPLSQQCLLYLARRIPRARLLLLLNERTGIQAADRAFRADLTHQPHCRRLKLGPLSAGAVAAMLGERLDTTVTDQLAGECHAFSGGNPLLVRAVVDDQPHRGEHGRPGALVPGEAFADAVLACLHRSGAHTVEVARGLALLGDFATPEFVGALIGAGTASVTEVLERLEAIGLLEGGRFRHPVGRTAVLHHMGVTRRVELHLRAAELLHREGVEARAVAEHLVAADGHPGPWAVSVLQDAATREVAGGRVAFALDCLELARRSCADERRRAVLTVLLADTELRSSPSSASTRHLSRLNAALREGELGGRLTVTAIDHLLWFGHTDQAGEALERLRGSVEPLDAETTASLRVLQRSLASSYPGLLARMPPGAVEPVAKEPTPVTVANDPVLHAAEALASVLTSGPNADAVTAAEQILQSGRLTGATLTTLTNALYALIYADRLDLALPRCDALLAEARARKFPTGESLIVAGRAEIAVRLGDLAGAEECASAATSLVPAPHWGVGLGVPLASRLLAATATGRFDVAESVLDQAVPQGMFGTRFELHYRYACGDYYLATGRPHAALGEFQICGELMADWGIDTPGLVPWRVGAAQAMVALEERAQARRLVEEQLARGGTGAVRSRGVALRVLASTLDPRQRFRPLREAVDILHGCGARLELARAFADLSQVHQMLGSSERARMIARRAWQLAKACQAEPLCQQLMPGSGAVVPRAHLSRPVKAGGVEALSDAERRVAALAGQGLTNREIARKLRITVSTVEQHLTRAYRKLNVRRRTDLPAETQLDFVGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPZ9</accession>
    <name>A0A2G1XPZ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">BLA24_03165</name>
        <name evidence="11" type="ORF">CYQ11_05465</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53318">
        <property type="protein sequence ID" value="PHQ53318"/>
        <property type="gene ID" value="BLA24_03165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12415">
        <property type="protein sequence ID" value="PPT12415"/>
        <property type="gene ID" value="CYQ11_05465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="398" mass="43223" checksum="E60C9E0CDBB3CCC8" modified="2018-01-31" version="1">MTERVVLAYSGGLDTSVAIGWIAEETGAEVIAVAVDVGQGGEDLDVIRKRALACGAVEAEVADAKDEFAEEYCLPAIKANALYMDRYPLVSALSRPTIVKHLVAAAQKHGASTVAHGCTGKGNDQVRFEAGISSLAPELKCIAPVRDYAMTRDKAIAFCEAKGLPIATTKKSPYSIDQNVFGRAVETGFLEDIWNAPIEDVYDYTANPATPREADEVVITFERGVPVALDGKPVTVLQAIQQLNERAGGQGVGRLDMVEDRLVGIKSREIYEAPGAIALITAHQELEAVTVERELARFKRQVEQRWTELVYDGLWFSPLKRALDGFIAEANEHVSGDIRMTLHGGRAVVTGRKSEKSLYDFNLATYDTGDTFDQSMSKGFIEIFGLSSKIAAKRDLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ12</accession>
    <name>A0A2G1XQ12_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="14" type="ORF">BLA24_03085</name>
        <name evidence="15" type="ORF">CYQ11_05385</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53303">
        <property type="protein sequence ID" value="PHQ53303"/>
        <property type="gene ID" value="BLA24_03085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12400">
        <property type="protein sequence ID" value="PPT12400"/>
        <property type="gene ID" value="CYQ11_05385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02145">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nitroreductase" evidence="13">
        <location>
            <begin position="683"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ53303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1242" mass="125954" checksum="ED0936C0480788D8" modified="2018-01-31" version="1">MTDTGRFPDEGQPENAGALPGHPLPADAAGPADTGSQAPYTFIDHDAADEDDLLLMPGAQGAWMEQPAATGGTHETGGRDTGSVDYTGVRTTPPAAAAPAPRRPLHMGPPVPEPSTGVVRSLADRGPAAPQQPVGAPARQAAPQAGGVEYLDAGPDETLGGAPATAFVPAQNTGAAAVQTAPAPVAPEMVAAAPAVPAEGAAVAATTTAGGPAVAAEPVAEAVSAPAAQQSATPEETPAHGLDLGAPQPAPAVLQQDAAAGVLGRLAAVVSADAHPQGAAQPAGETGGADGTPLPPSVAVPADGGAEAAAPQPVQAPPAPAQEAPPAPAPAVAPEPQGAEAPPTWELPETPEAVAVEAPEQVTAPQPEAVAEPVQPAQPVDVPPVQPEPAVAVVADAPEAVAEAVSVPAQRAVEEAQPVTDAAEPVAAPVVAEAVAPDATVTTAEAAPAQPAAAPEPQAPAAPVVPQPQAPAAPEAEAVPAQPEPVQAPVAQPEPEQPVVEQPAAPVTDQAAVPQEPAAPQAAVAPQEPAAVPVEQPAQAPAPVTAPPAEVPAPAQDAEAVAPAPAPQQQAPVAADAAPAAPQQHAPAEPAPEAEPVPVQSAPSGTEEAQPAQASPVAPEVQEPQAADVTPQSPEAPQTPEAPEAVEAPEALEAQEPAAAPEPVGPPAPAFDESERAAVHRVIRERRDIRNGFRTDPIPHEVLLRVLEAAHTAPSVGHSQPWDFVVIRSAETRKAMHELAVRQREAYAKSLPKARAKQFTELKIEAILETPVNIVVTADPTRGGRHTLGRHTQPQMAPYSSALAVENLWLAARAEGLGVGWVSFFDEREMVRELGLPEHLEVVAYLCVGYVDEFPDEPELMQAGWSKRRPLSWVVHEETYGRRALPGEDPHDLLAETLRGIRPLDAKALGEAWERQKRMTKPSGALGMLEIISAQLCGLSRKCPPPIPEPAAVAIFAGDHGVHHQGVTAWPQEVTSQMVANFLGGGAVCNAFAKQVGAEVCVVDVGVASELPSTPGLLPRKIRPGTSDFTTGPAMSREEALRAVEVGIETARDLVTAGNKALLTGEMGIANTTVSAALIAVFTGADPAEITGRGTGINDEMHARKIDVVRRALELHRPDPEDPIGVLAAVGGLEHAALVGLILGGASLRTPVILDGVSAGAAALVARAIAPEALAACIAGHRSAEPGHVAALTKLGLRPLVDLDLRLGEGTGALLALPVVQSAARAMHEVATFDTAGVTEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ54</accession>
    <name>A0A2G1XQ54_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_01895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000034">
        <property type="protein sequence ID" value="PHQ53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53353">
        <property type="protein sequence ID" value="PHQ53353"/>
        <property type="gene ID" value="BLA24_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="140"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="218" mass="23583" checksum="DED1F0578830D03C" modified="2018-01-31" version="1" fragment="single">MADTHVLFVEDDDVIREATQLALERDGFMVTAVPDGLLGLESFRARRPDIALLDVMVPGLDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGAVLVARIRAVLRRFGHASGANGAADGTPETIEGGTLRFGDLEVDTEGMEVRKAGTPVALTPTEMRLLLEFSAAPGTVLSRDRLLERVWDYGWGGDTRVVDVHVQRLRGKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ77</accession>
    <name>A0A2G1XQ77_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_01390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000021">
        <property type="protein sequence ID" value="PHQ53397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53397">
        <property type="protein sequence ID" value="PHQ53397"/>
        <property type="gene ID" value="BLA24_01390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="237"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="402" mass="42722" checksum="86DFA389B53A526B" modified="2018-01-31" version="1">MPEPSLAVSLAPRRPADDAKDGSGKSQGQVDAAAAKDASKAQIKITPKGGTTDAGISTDAVQVTVSDGELTSVKMTTEKGTPVEGSISSDKKTWKPNSQLERSTKYKVVAEAKDDKGRKATENSSFSTVSPANSFIGAFTPEDGSTVGVGMPVSINFNKPIKDRKAVQSHLEVTSSSGQKVVGHWFGDQRLDFRPQDYWKANSQVTLKMNLDGVEGAPGIKGVQNKTINFKIGHAQVSTVDAKTHKMTVTRDGQVVKTIPISAGSPSNPTYNGKMVISEKFKETRMDGSTVGFSKADGKGEYDIKDVPHAMRLSTSGTFIHGNYWGSGVFGVANTSHGCVGLEDKQGADDPNTPGSWFFSNSILGDVVEVKNSDDKTIAPDNGLNGWNMDWNQWVQGSATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ2</accession>
    <name>A0A2G1XQJ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00575</name>
        <name evidence="3" type="ORF">CYQ11_07585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53461">
        <property type="protein sequence ID" value="PHQ53461"/>
        <property type="gene ID" value="BLA24_00575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12766">
        <property type="protein sequence ID" value="PPT12766"/>
        <property type="gene ID" value="CYQ11_07585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="23628" checksum="2B742970D2BB2D19" modified="2018-01-31" version="1">MEGTGVRFRTVRAALFTALCVTLSAASHVLLSRAPLPLSTVTVLSGAFFALSYALAGRERGYWPIATLLVPLELSADTVFTTGQHACYGQAGGPVAGPLRSMGVDLVCGGGDFGTPLARMAGPAGSGHMTDGVAGHSATPWLLLAAHVAVGLLAAAWLRRGEVALFRLLRAVASLAFRPLLPLVAALAAHARPARPPVRPVRDTLSARVLPLLVHSVVRRGPPPCPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9B1</accession>
    <name>A0A2G1X9B1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30325</name>
        <name evidence="3" type="ORF">CYQ11_23420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47811">
        <property type="protein sequence ID" value="PHQ47811"/>
        <property type="gene ID" value="BLA24_30325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15436">
        <property type="protein sequence ID" value="PPT15436"/>
        <property type="gene ID" value="CYQ11_23420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13856" checksum="B6A0E3F1CD96032E" modified="2018-01-31" version="1">MGLVVEPDVRSGESRRWLADVVGQLEGTREDALRELEARARAFPPPRWAQRTRLLRTAEGFLLVVNGSWADGHHRFSVAEVLHDSAAPPPEAPRDSAVPPPGAVPDVPRDADGVARTPSWLGRTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA05</accession>
    <name>A0A2G1XA05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_31585</name>
        <name evidence="5" type="ORF">CYQ11_24635</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47999">
        <property type="protein sequence ID" value="PHQ47999"/>
        <property type="gene ID" value="BLA24_31585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15625">
        <property type="protein sequence ID" value="PPT15625"/>
        <property type="gene ID" value="CYQ11_24635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="27503" checksum="73569F93B2F4E133" modified="2018-01-31" version="1">MTDATVKTPNAGKKAKDLNEVIRYTLWSVFKLRDVLPQDRAGWADEVEELFAQLAEKDVTVRGTYDLSGLRADADVMIWWHSETSDALQDAYNLFRRTRLGRALEPVWSNMALHRPAEFNKSHIPAFLADETPRDYVSVYPFVRSYDWYLLPDEDRRRMLADHGKMARGYPDVRANTVASFSLGDYEWILAFEANDLYRIVDLMRHLRASEARMHVREEVPFYTGRRKAVADLVAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAJ7</accession>
    <name>A0A2G1XAJ7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="9" type="ORF">BLA24_32995</name>
        <name evidence="10" type="ORF">CYQ11_26045</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48235">
        <property type="protein sequence ID" value="PHQ48235"/>
        <property type="gene ID" value="BLA24_32995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15862">
        <property type="protein sequence ID" value="PPT15862"/>
        <property type="gene ID" value="CYQ11_26045"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="203" mass="22022" checksum="B7CD53A8F25A1D39" modified="2018-01-31" version="1">MPITSAQGRAADSAAVPASDDAAEPIMLELVDENGRTIGTAEKVAAHLAPGRLHRAFSVFLFDDRGRLLLQRRALGKYHSPGVWSNTCCGHPYPDEPPFVAAARRTGEELGLAPALMREAGTVRYNHPDPASGLVEQEYNHLFVGTVRAEPRPDPEEIVETAFVTPAELEELRAKHTFSAWFTTVLDAARPAIRELTGAGTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAL1</accession>
    <name>A0A2G1XAL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage tail sheath family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_33200</name>
        <name evidence="5" type="ORF">CYQ11_26250</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48266">
        <property type="protein sequence ID" value="PHQ48266"/>
        <property type="gene ID" value="BLA24_33200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15896">
        <property type="protein sequence ID" value="PPT15896"/>
        <property type="gene ID" value="CYQ11_26250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="257"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="3">
        <location>
            <begin position="418"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="533" mass="57718" checksum="949C9842D0020D3B" modified="2018-01-31" version="1">MRVLRRSGWVKGRIPDERGKQGMVSGPLAPGVFIKERSSGVRTITGVGTSTPAFLGYTVCGPQAPTPPVRINSWSEFVDTFHFRSPMGAEELRRELERLSGAITEAGAKLEPLEADFKEKATTGDDAPLTEPEFTVLTEVQAADWADEVVGAEKRAAAEAAAKKVAEAEPLSGPYGLWIAAGNELAGLKRRKKELTVFAEYFEQSGKIQLPEAVYGFFANGGTSCYVLRLDPGKTLAGEVDGDPDQRTGLAGLKTVPEVTMVAVPDVWREGTTAETGAAVMGQVVSHCVTMRNRLALLEPPPDTAPAGVPEFLGQLAGPEVEDAAFTALYYPWVNVPGVDGIPRTVVPSGHLAGVWARTDAERGVFKAPANQNLRGVLSLPTLLTDQRHGELNDKGVNCLRVFPDRGLLVWGARTRSSSRDWRYLNVRRLVSFLSDSIRQSSTWAVFEPNDDRLWATLRHSVSSFLTDQWRQGALLGRTPDEAFYVICDRTNNTSSTIDAGQVICDIGIAPVRPAEFVQFTITQIAGQPGANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAL5</accession>
    <name>A0A2G1XAL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33105</name>
        <name evidence="3" type="ORF">CYQ11_26155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48252">
        <property type="protein sequence ID" value="PHQ48252"/>
        <property type="gene ID" value="BLA24_33105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15882">
        <property type="protein sequence ID" value="PPT15882"/>
        <property type="gene ID" value="CYQ11_26155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="161" mass="17430" checksum="C9BFEC98703FE24F" modified="2018-01-31" version="1">MSRIAHSCGVVPSHDALSLGLCGSFLPGRRQDAFHFPALTTSVAEARRRVLARLREWGMDEMACDDAQLVVSELVTNAVRHTDSDKVSCQLRLSGTGLRIEVVDQGHAPTEPRARCSGTDEESGRGLLLVGALSHAWGVRPDDDGRGRVVWADLPHGRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAM8</accession>
    <name>A0A2G1XAM8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_33375</name>
        <name evidence="5" type="ORF">CYQ11_26425</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48294">
        <property type="protein sequence ID" value="PHQ48294"/>
        <property type="gene ID" value="BLA24_33375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15925">
        <property type="protein sequence ID" value="PPT15925"/>
        <property type="gene ID" value="CYQ11_26425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758449" evidence="2">
        <location>
            <begin position="24"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="100"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="245"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="40062" checksum="86A778A5B5508E46" modified="2018-01-31" version="1">MATRHIALLACGAALAAAPPGAAVPSTHGGSVHRVRPGQSIQKAVDAARPGDTILLSPGTYRESVRISTSRLTLRGSGPSSTVLVPAGATGTGTGPCAAAGHGVCVAGSAGRPVANVSVRSLTLRGFAKNGLWASWTDRLTVQQVTAEKNGTWGIAQERSLRSSLLQNTARNNGDAGLFLSNTMDKEEGAADTKGTVVSHNRVSGNRIGITVRRLRNLTVEHNEATANCAALFVVGDENSPRAGAMTLRRNNIHENNKLCPKTPRLPSLQGSGIVLTGAEQTLVTYNRVVGNVGSSPLSGGIVLFKSFVGAHNERNKIHDNVVLRNGTADLANRDTGTGNTFRGNTCTRSEPSGLCRPHPASPASSASAPRPPTHAARQQRQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAP0</accession>
    <name>A0A2G1XAP0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance/dioxygenase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33395</name>
        <name evidence="3" type="ORF">CYQ11_26445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48298">
        <property type="protein sequence ID" value="PHQ48298"/>
        <property type="gene ID" value="BLA24_33395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15929">
        <property type="protein sequence ID" value="PPT15929"/>
        <property type="gene ID" value="CYQ11_26445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="135" mass="14861" checksum="8B82F2F911BC34D1" modified="2018-01-31" version="1">MPFAPCLSVRDTAASIAFYKQLGFDVGSSTARPGDDIHMLLYQGGFCAMLYSNADLKNWLPSLADTPIGFAGMFYLGVDDFDGAHDRISRHAEIVKETDTDHTGQRMFYFRDPDGYVVGINDQAAFQASDLGKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAT0</accession>
    <name>A0A2G1XAT0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_31520</name>
        <name evidence="6" type="ORF">CYQ11_24565</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48344">
        <property type="protein sequence ID" value="PHQ48344"/>
        <property type="gene ID" value="BLA24_31520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16770">
        <property type="protein sequence ID" value="PPT16770"/>
        <property type="gene ID" value="CYQ11_24565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304565" evidence="3">
        <location>
            <begin position="38"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="308"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="666"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="727" mass="75711" checksum="EB107B618A535020" modified="2018-01-31" version="1">MPLLGGARPPIAALLVLLLVVAATTALVLGDRERAAADTAVLTSQQHVAEDGALSLRASLDESITDIERAATQFGTGGGGAPDEILDKLGKVYNKWRGTAVVDPAGGTLLAARGETIPLAPVLGNGDGKGKDAKDLLGPRLVRLASGETRMLVVAALRGADHPLLLVASGTLNAPGISSGEGRSLLVVDSAGTVLASDGPSVARKSWAKRVRETAAADSAKTPEPGGHPGASGHLMGDSRGKVRTAVGYAAAGRAPGETSAAGGLGLSVITSVKVEGDPTAVRTQAFGLVAAGILLVLALVVGWVLLRTVQRPLLRLYLESRRLARGELDRPVARFKGREPARIGAALESLRRQLLGGRPTRAGRARGGFGTRGTVVVCAVLLLAWAAPLLLFLNRPGSSVSVPEQLVDDQRRRTDTASDRVRRALNEGWADVASVAQALAGGERAKSGDPAAYDKAVLDQTLREHGRYRAVYVIDGEGKVLSRSGASPRHPAGKPPVEDSVAQLNTSGKEPAVAAYAAVPGAKGLTVVGEYDPQFLISMVTRPGLGQVWLIDKGHRIIAADRAHGFRAFAKLPSGHLDALADTAVKKAGRTTGTAVLHRSSRSSDIAAAAPFTGGGAVKDLGWQVVSSQPTSWLELPEYTAQRHTMLAGLLGVTAAVACLGWLHIIVIRPLRSLADQAEALAAGDRKTVLFPQHHDEAGAVVRNLELIRQRLRPTQKPQARPAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB25</accession>
    <name>A0A2G1XB25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_08420</name>
        <name evidence="3" type="ORF">BLA24_13615</name>
        <name evidence="2" type="ORF">BLA24_30090</name>
        <name evidence="5" type="ORF">CYQ11_01335</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000166">
        <property type="protein sequence ID" value="PHQ48401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000091">
        <property type="protein sequence ID" value="PHQ52296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48401">
        <property type="protein sequence ID" value="PHQ48401"/>
        <property type="gene ID" value="BLA24_30090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51536">
        <property type="protein sequence ID" value="PHQ51536"/>
        <property type="gene ID" value="BLA24_13615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52296">
        <property type="protein sequence ID" value="PHQ52296"/>
        <property type="gene ID" value="BLA24_08420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11720">
        <property type="protein sequence ID" value="PPT11720"/>
        <property type="gene ID" value="CYQ11_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="129" mass="14310" checksum="8DCE0B59B1051D9A" modified="2018-01-31" version="1">MTATPIDLFASFVHLRPDGRAQAEQPAFDVERDGWQLMTFHGETDADVHADHWEVHPEAEEVVCCLTGGIRLCLRPEQPGEEEEEIKLAAGTAVVVPRGRWHRIALDVPSDIMSVTVARGSRLEERTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBJ5</accession>
    <name>A0A2G1XBJ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29445</name>
        <name evidence="2" type="ORF">CYQ11_06030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48596">
        <property type="protein sequence ID" value="PHQ48596"/>
        <property type="gene ID" value="BLA24_29445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12514">
        <property type="protein sequence ID" value="PPT12514"/>
        <property type="gene ID" value="CYQ11_06030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="156" mass="18562" checksum="4C3710755F38478E" modified="2018-01-31" version="1">MEREAWRLETLPVYTMPQEAEKLKRFLAGEKSPDDYASAWMDEVQQWTSEGKSVGRVHVVTRPLSDYLRFEFEYYYRHHVKVGEDIRILDLTDRENPGLPDQDFWMFDESKVVLMNYRADGTQISRELYEGDPEPYRRWRQIAVAEAVPFLEYVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBK8</accession>
    <name>A0A2G1XBK8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">BLA24_28380</name>
        <name evidence="6" type="ORF">CYQ11_07090</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48637">
        <property type="protein sequence ID" value="PHQ48637"/>
        <property type="gene ID" value="BLA24_28380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12684">
        <property type="protein sequence ID" value="PPT12684"/>
        <property type="gene ID" value="CYQ11_07090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="27712" checksum="41C7359F68B43A6F" modified="2018-01-31" version="1">MSARTPLMAGNWKMNLNHLEAIAHVQKLAFALADKDYEATEVAVLPPFTDLRSVQTLVDGDKLKIKYGAQDISAYDSGAYTGEISGAMLAKLKCTYVAVGHSERRQYHGETDELCNAKVKAAFRHGLTPILCVGEGLDVRKAGQQVPHTLAQVDGALKDVPAEQAESIVIAYEPVWAIGTGEVATPEDAQEVCGAIRARLVELYSQELAEKVRIQYGGSVKSGNIAAIMAQPDVDGALVGGAALDADDFVKIVRFRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBR0</accession>
    <name>A0A2G1XBR0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28675</name>
        <name evidence="5" type="ORF">CYQ11_06790</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48684">
        <property type="protein sequence ID" value="PHQ48684"/>
        <property type="gene ID" value="BLA24_28675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12635">
        <property type="protein sequence ID" value="PPT12635"/>
        <property type="gene ID" value="CYQ11_06790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="3">
        <location>
            <begin position="96"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="205" mass="22453" checksum="898F228DFEC7BD54" modified="2018-01-31" version="1">MSAPVPLEKPAPEETEGGPAPAHGHAHAHRFWSARRVPAAFLAALLLAGAGVLLYDVVAVRAHHPAMAWRRRLAHELATRPLDDPWVTTGAALAVVLGLWLIVLALTPGRRRVLPMRRDTPDVRAGLDRRAAALVLRDRAMEVPGVQSVRVDVTRRRVRARARSHFRDLDEVRTDVGAVLAAGVRELGLAREPSLSVHVHRPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC36</accession>
    <name>A0A2G1XC36_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27505</name>
        <name evidence="7" type="ORF">CYQ11_18140</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48817">
        <property type="protein sequence ID" value="PHQ48817"/>
        <property type="gene ID" value="BLA24_27505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14537">
        <property type="protein sequence ID" value="PPT14537"/>
        <property type="gene ID" value="CYQ11_18140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="366" mass="39718" checksum="F160C080060B9862" modified="2018-01-31" version="1">MSDFVPGLEGVVAFETEIAEPDKEGGALRYRGVDIEDLVGNVSFGNVWGLLVDGAFNPGLPPAEPFPIPVHSGDIRVDVQSALAMLAPVWGLKPLLDIDEATARDNLARAAVMALSYVAQSARGQGLPMVPQREIDKAETVVERFMKRWRGEPDPKHVKAVDAYWTSAAEHGMNASTFTARVIASTGADVAAALSGAVGAMSGPLHGGAPSRVLGMIEEIERTGDAAAYVRHALDRGERLMGFGHRVYRAEDPRARVLRRTAKELAAPRFEVAEALEKAALEELHNRRPDRVLATNVEFWAAIVLDFAEVPAHMFTSMFTCARTAGWSAHILEQKRTGRLVRPSARYVGPGPRDPREVTGYPDIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC80</accession>
    <name>A0A2G1XC80_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2771 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27735</name>
        <name evidence="3" type="ORF">CYQ11_17905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48857">
        <property type="protein sequence ID" value="PHQ48857"/>
        <property type="gene ID" value="BLA24_27735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14496">
        <property type="protein sequence ID" value="PPT14496"/>
        <property type="gene ID" value="CYQ11_17905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305489" evidence="1">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="160" mass="16782" checksum="6AC7C05760BB50A9" modified="2018-01-31" version="1">MTAAIFRGRRLRAAATVGAVAFGLVALSACDKPTPLATVTVGSKTVTTEAACYNDGESIETPKVASCLKEGEDKTVKAAMEDKIRFGVDPKIADKGWTIFINDQAVEPEPNNKTFRSIPASAFFSTGQGPAVAKTKVSIVEAASGKALGVWNFTLERDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC81</accession>
    <name>A0A2G1XC81_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27715</name>
        <name evidence="3" type="ORF">CYQ11_17925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48853">
        <property type="protein sequence ID" value="PHQ48853"/>
        <property type="gene ID" value="BLA24_27715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14500">
        <property type="protein sequence ID" value="PPT14500"/>
        <property type="gene ID" value="CYQ11_17925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="78" mass="7931" checksum="E2642031F873919E" modified="2018-01-31" version="1">MSSETPRAGDLLVRTGAVVFLVGAVATLATVAPLFLGADPLPPAAYFVCMLMGAGFVIAAAGVLRSVAEQRREARGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCH0</accession>
    <name>A0A2G1XCH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27755</name>
        <name evidence="3" type="ORF">CYQ11_17885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48859">
        <property type="protein sequence ID" value="PHQ48859"/>
        <property type="gene ID" value="BLA24_27755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14494">
        <property type="protein sequence ID" value="PPT14494"/>
        <property type="gene ID" value="CYQ11_17885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1092" mass="114187" checksum="79A72A3849378FCF" modified="2018-01-31" version="1">MDPFGTARLRRGVLDAWAASPARFREDANAEEDLALGGYRDRLVVELAQNAADAAARAGVPGRLRLTLRPAHGDEPAVLAAANTGAPLDAAGVESLSTLRASAKREGDDSAVGRFGVGFAAVLAVTDEPALVGRTGGVRWSLTEARALAEDTASASPGLGTEIRRREGHVPLLRLPLPAEGAAPEGYDTCVVLPLRDGTAEDLAGRLLAGVDDALLLALPGLTEVVVETPDAAPRTLTRRQEGVYTVVEDSARAVPVTRWRVGSAGGGLDPALLTDRPVEERLRPHWSVTWAVPVDADGAPVRPRTAPVVHAPTPTDEPLGLPALLIASFPLEPTRRHTAPGSLTDFLIGRAAEAYSELLRSWHPVSTGTLDLVPAPLAQGALDAELRRQVLQRLPRVPFLSSAAASVPTEAEPAPASGGVEGIPWTEGPDAATHTAEPAGAAPHGPAAADTWDDPFAPGGPGGEPAALRPVDAEIVEGAGAETVAVLGELFPGLLPAGLERRPELRALGVARVSLGEVVDRLAGVERSPAWWWRLYDSLAGVDPDRLTGLPVPLAGDAGDEGPGRTAIGPRQVLLPSVDATGSERLSRLGLKVAHPDAAHPLLEKLGATPSSPRAVLTTPQVRAAVAASLDAEDYWDEDGLDNDTLVEVVLSLVRDAGLAPGDEPWLAALALPDEDGELAPAGELVLPGSAFESVIRPGELAACDAELAERWGEQPLTAVGVLADFALVRATDVVLDPDELEPRDGDFAEPDDVGLLDAVDVWCEDVLDRLPDAPVPPVATEVVAVRDLDLVDDDAWPQALALLSRPPLRDALTAPVRVLLPDGTTESVRPYTAWWLRGHPVLDGRRPAGLRVAGGDPLLAGLYEAADTAGLADEQVLRALGVRTSVAALLDEPGGAAELLARLADPELPVGPAQLHGLYGALAGLDPEEVTLPDELRAVVDGAVRVVDAAEAVVADAPDLLPLAAGVALLPVRPDRAAELADLLQVRRLSQVVTASVLADEGEVREVPQGLRALLPGAPATYVEHEELVADGIELDWRYGPDRVLHAATLEGVAAGLAWAAGQWSRRFEAAALLEDPSRTEELARARWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCI2</accession>
    <name>A0A2G1XCI2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_28015</name>
        <name evidence="9" type="ORF">CYQ11_17625</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48905">
        <property type="protein sequence ID" value="PHQ48905"/>
        <property type="gene ID" value="BLA24_28015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14446">
        <property type="protein sequence ID" value="PPT14446"/>
        <property type="gene ID" value="CYQ11_17625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="224"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="754" mass="77911" checksum="08CC2CE3FD574F9C" modified="2018-01-31" version="1">MPPPGARRPEAASPPARAGALERLGRWCARHSVVVVVVWLVALGVLRLVQDVAGGTYSDDFSLPGTQSYQGQQVLKANARGASGTGGQVVLHDAHGPLTDVRGQVDQTVSALRKLPHVVAVENPLPPPSGSPAKPEPTGALSADGTIGYLTVRFDTTPASLGHSYVHRVDDAVAPLRSAGVQVEYGGPLGELARPATHDFTSEAVGFTVAVIVLLIGFGSVIAAVYPLVSALIGVIIGLACLSLLAAAFTFASVSPTLATMIGLGVGIDYALFLITRHRQLLLDGTGPKAAAGRAVATSGRAVLVSGGTVVVALTGLYVSGISFIGKLGAAAAVTVVTAVLAALTLVPALLGLAGRRLDRWRVRTPVAEGATGTEAGTWHRYALQVARRPWWFLAGGLVTVAVLAIPLFSIRLGHVGDGADPTTFTDRRAYDLISEGFGPGANGPLTLVVDQSAVPAGDRAALAAKLGKALTGVPGAAGVTPPQPTGNGQVLTATAVSAVPPQDAGTTDLFNRLKDDVLPQAVAGTAARTYVTGSTAAQVDFLELISARLPLIIAVVVGLAFLLILIVFRGLLVAVKAAALNLLSIAASYGVVVAVFQWGWGGPALGVDGTVPIESYVPMMMFAIVFGLSMDYEVFLLSRVHEAWRRTHDNEASVAHGLEVTARVITCAALIMVSVFAAFVISDNVVVKMLGLGLAVSVLIDATVVRLLLVPAAMTVLGRNSWWVPRWLDRILPHVDAEGAPQGPGMGSERSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCL4</accession>
    <name>A0A2G1XCL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type VII secretion protein EccC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Type VII secretion protein EccCa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_22900</name>
        <name evidence="8" type="ORF">CYQ11_23175</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48958">
        <property type="protein sequence ID" value="PHQ48958"/>
        <property type="gene ID" value="BLA24_22900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15397">
        <property type="protein sequence ID" value="PPT15397"/>
        <property type="gene ID" value="CYQ11_23175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="450"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="812"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="1101"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="473"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="831"/>
            <end position="838"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1319" mass="142308" checksum="659DF5389F53BB77" modified="2018-01-31" version="1">MSQIIVKRPPRVMPPEIPADELQLESPPELPRGQQEGMAMQLLPMLGMGSSVVFFFMPGTAPIMRIMGAMMLVSTVAMAVAQVIRYRKGSQGAAVESRRDYLKYLAQTRQKVRRTARAQRDAQFYLHPAPEQLWSLVAEGSRLWERRVSDKDFGQARVGLGPQQLWTPLVAPTTAPVDELEPLSASAMQRFLAVHGSLDGLPVAVSIRAFYHVVVSGEREAVRGTARSLVASLVTLHSPEDLVVAVVAGQGAAEEWDWCKWLPHTQVPGSTDGAGTKRLFSDDLTELEDLLGNRLLGRPRFSRDGQPLLDQPHVVVVLDGGTVPPDSLLASAEGLQGVTVVEVVPGELDESRGGLSVVVRPGQLRLESAAATYQGVPDSLSVPAAEALARQLAPMRMGGGGDDDEPLLANLDFTDLLGLGDAGSVDTSTAWRPRSMAERLRVPIGVGEDGSPVMLDLKEAAQEGMGPHGLCVGATGSGKSELLRTLVLGLAVTHSSETLNFVLADFKGGATFAGMAELPHVAAVITNLADDLTLVDRMRDSITGELQRRQELLRAAGNYANLTDYEKARAAGAPLEPLASLVLVIDEFSELLTAKPDFIEMFIQIGRIGRSLGVHLLLASQRLEEGRLRGLDTYLSYRIGLRTFSAAESRTALGVPDAYHLPSVPGSGYLKFGTDEMTRFKAAYVSAVYRGGVTTTTRTGSFPTDRRPVPFTAAPVPVRYAEPDPAVPLTAPGRDDDALADTVLDVIVRRLEGQGPAAHQVWLPPLDEAPSLDQLLSGLAVSPERGLHAPGSPRGGGLRVPLGLIDKPFEQRRDVLFRDFSGAAGHMLVVGGPRSGKSTLLRTLIGAFALTHTPHEVQFYGLDFGGGALSAVDGLPHVGGIASRLDPEKIRRTVAEVAGILNRREEFFRDNNIDSISTYRQLRAAGRLPGEPWGDVFLVIDGWFSFKTDYEMLEPVVADIAARGLGLGVHLVVTVSRYMEMRAALKDQLLSRLELRMGDPLDSELDRKVAANVPVGVPGRGLTAEKLHFLGGLPRVDGASGGGDDLSEATAAFVKASVENWPGPHAPQVRMLPRTLSVRELPDGHAEPQRGVAIGIDEMNLAPVFVDFDTDPLFAVYGESESGKTALLRLLIKQLTERYTPEEALFCVGDYRRSLLECVPEPYLAGYATTQNAFDPYLADMNALINSRAPGPDVTPQQLRNRNWWRGPRAFIIVDDYDLVATSSGNPLAQLVDNLPYARDTGVNFIIARSTAGAGRSMYEPFIQRFKELGAQGVVLSGDRGEGELLGNVKPRPLPPGRGIFVSRKQGSSLIQTGWLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD56</accession>
    <name>A0A2G1XD56_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_23695</name>
        <name evidence="7" type="ORF">CYQ11_22380</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49089">
        <property type="protein sequence ID" value="PHQ49089"/>
        <property type="gene ID" value="BLA24_23695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15265">
        <property type="protein sequence ID" value="PPT15265"/>
        <property type="gene ID" value="CYQ11_22380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="6528" checksum="DC32BC485AC1D4DE" modified="2018-01-31" version="1">MRVSIDSDVCIGSGMCALTAPSVFTQDDDGFGTVRPGRADGGGDPLVKEAVRSCPVQAVTVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD99</accession>
    <name>A0A2G1XD99_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ORF">BLA24_24415</name>
        <name evidence="8" type="ORF">CYQ11_21655</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49213">
        <property type="protein sequence ID" value="PHQ49213"/>
        <property type="gene ID" value="BLA24_24415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15136">
        <property type="protein sequence ID" value="PPT15136"/>
        <property type="gene ID" value="CYQ11_21655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="28876" checksum="E10472D556B7F23D" modified="2018-01-31" version="1">MSLASREATASARESLDALADNTSVDAAKLAEELAAVTALLDREVSLRRVLTDPAQDGEAKAGLAKRLLGGQVGDECADLVAGMVRSRWSRSRDLVDAIEELASGADLIAAERAGDLDDVEDELFRFGRIVASNSELRSALTDRVAVRSAKAGLLHELLGGRANPVTERLVVRLVTAPRGRSLEAGLNALSKLAADRRDRMVAEVVSAVPLTDQQKQRLGEGLAKLYGRRVHLNLDVDPEVLGGIQVRIGDEVITGTIADRLAEASRRMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDA4</accession>
    <name>A0A2G1XDA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_24070</name>
        <name evidence="6" type="ORF">CYQ11_22000</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49149">
        <property type="protein sequence ID" value="PHQ49149"/>
        <property type="gene ID" value="BLA24_24070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15200">
        <property type="protein sequence ID" value="PPT15200"/>
        <property type="gene ID" value="CYQ11_22000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758471" evidence="4">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="408" mass="43415" checksum="0E8940A9D1B0F3C7" modified="2018-01-31" version="1">MNRRTLTKSAVLATALLLTGGTGLAPARAATEGGAVVPRLPAPTGPYATGVTALYLVDRSRPDPWEPKIPVREVLVTVFHPARTVRGRPAAPQWTQGAAELFGQLAPQAGHRELPAAGVDWAATATHSRKLAPATGGRRPVLLYSPGGGDPGALGTGLAEDLASHGYVVVVVDHPGDGLAVEFPCGTSGRDTVRATVFRDDPRAHPAMFRTAIDTRIADIRFVLDQLEVLAAGRNPDALGRALPEHLGRALDLRRVGVYGHSAGGTAVAEALYEDRRVGAAVTMEGYLDYAPEGPGRPGELFPVARHGVDRPLLLLGTDGFRSEELDRSWSAVLARSGGRVRRRQLDDSSHWVFTDYAAFAPQLQTAALMTAEGRNKLVGPIDPARSVPAVRGQVRSFFDRHLPARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC1</accession>
    <name>A0A2G1XDC1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24190</name>
        <name evidence="3" type="ORF">CYQ11_21885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49169">
        <property type="protein sequence ID" value="PHQ49169"/>
        <property type="gene ID" value="BLA24_24190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15181">
        <property type="protein sequence ID" value="PPT15181"/>
        <property type="gene ID" value="CYQ11_21885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="440" mass="44127" checksum="B887340837F5590A" modified="2018-01-31" version="1">MPTDEEHESGGPEGLARTTPRHAAPRRPLLARLHMPAGKAVALAAMPGAVLMGMGLTPTLASAKPPSPGQLFEGACAPAPDGADQPSPGASTSPTPSPGASTPSAKPEDAQKADEAEKPGEGDKAEKTETADKAGTAAKPEAAGKPSPAGTPGVAKPAPAPSAPTASPTPSAAKPGSILDPLGLGDKLHDVLSGVTGGGAKPAPAPSASPKPSTAPSASAAAPGKAKDAPKVAPTPGGSAGPGVVPKPSGSPSPSASPSASASASPSPSPSASGSPGELPPCPKGTVVDENEHRAFPNQPWYLEASKLTLHGLTYEGVKRIRTVNGEQKSVLKFTADMLEIQDLHQIVNSQGRQYHVTGKGTNSTVSGGRITMYTEELKGNLLGLIPSTQSPTSVPPLIPGLKLPIPIFFTNVKIRQAGQFGGTLHIPNLHQYLTEGTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDL0</accession>
    <name>A0A2G1XDL0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein BLA24_25020</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_25020</name>
        <name evidence="8" type="ORF">CYQ11_21050</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49318">
        <property type="protein sequence ID" value="PHQ49318"/>
        <property type="gene ID" value="BLA24_25020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16700">
        <property type="protein sequence ID" value="PPT16700"/>
        <property type="gene ID" value="CYQ11_21050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="960" mass="105558" checksum="6047D339A8D62D4E" modified="2018-01-31" version="1">MPDRGGGPTGPRIRVGRPSRRVRTLLTTLGVLAGLAMLFVMFAGFWTDWLWYRSVHYSSVFTTTLGTKIGLFAVFGLLMAVAVGTNIWLAHRLRPPLSAMSTEQQSLDRYRMSIAPYKKWVLLAVAALVGLVAGASAAGQWRTWLQWVNGVSFGQRDPQFHKDISFYTFDLPWYRFLLSFGFAAAVLSLIAAALVHYLYGGLRLTSPSGRATAAATGHLSVLLGLFVTLKAVAYWLDRYGLAVKSSGLKSTDGWTGLRYVDANAYLPAKTILFIIALICAVLFFATLWRRTWQLPVIGFGLMVLSAVLIGGLYPAIVQKFQVQPNEQAKEAPYIKKNITATRQAYGIDGVDVKDYSGKSDTGSDKDKLRAEADATASLRLLDPNIVSPAFQQEQQVRGYYQFPSTLDVDRYKANGKEQDTVVGLRELNIRGIPERNWINDHFKYTHGYGAITAKGTSTDSSGAPDFTEKKLPTEGMLGSYEQRVYYGEKTTQYSIVGGPQKELDYSSDQGEKSYSYQGKSGVSLSNPVNRAAYAVAFGEPQILYSGAIGDGSRILYNRTPKQRVESVAPWLTIDGDAYPAVVDGRIQWIVDAYTTSNGYPYASRTTLGDTTADSLTNGQRAVVAQQNQVNYIRNSVKATVDAYDGTVKLYQWDTKDPVLKTWMKAFPGTVKAKSQISSQLMDHLRYPQDLFKVQRELLSRYHVTNPGTFYTGSERWEVPDDPTTKSGNAVPPYYLSMKMPDQREQAFSLTTTFTPKGRPNLGAFMAVDANAKSRDYGRIRILKLPSESTVWGPQQAQSKFNGDTAVANEINILKRGDSEVEYGNLLTVPLSGGLLYVEPVYVRGAGTNYPLLKKVLVNYGEKIAFKDTLAQALDEVFGGKAPDTTRPPSEGTTRPPSEGSANPTVKQAVKDAQDAFDAGQKALDKKDWAAYGKAQQDLKDALDRLAKAETAAEGGTKPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDV2</accession>
    <name>A0A2G1XDV2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25405</name>
        <name evidence="4" type="ORF">CYQ11_20670</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49385">
        <property type="protein sequence ID" value="PHQ49385"/>
        <property type="gene ID" value="BLA24_25405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14965">
        <property type="protein sequence ID" value="PPT14965"/>
        <property type="gene ID" value="CYQ11_20670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758326" evidence="2">
        <location>
            <begin position="34"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="331" mass="33881" checksum="DF95B1B3AA54BDF1" modified="2018-01-31" version="1">MSRIIVTRRGRLLRTVAACAVLLALAGYLVAQLVTGGPGAPRCTVRAAGQSYSLSPEQAVNAATISAVGSSRGLPERAVTIALATAMQESGLRNIHHGDRDSLGLFQQRPTQGWGTAGQITDPVYAAGKFYEHLVEVPGYSRLPLTVAAQRVQRSGFPQAYAKHEPDASLLSAALTGRAAATFSCTKSPADGKPGDPSAVRTKLTREFGTGVLPAVTSGTGGDGLGGAAGGRTVTVPVPAQSDRPAADDGNAPRGWELASWAVAHAAELRIERVSFAGRVWSAKNSADGWRKSAAGSEDRDRDGSTGVPGGGTGSVSGGNTSGVVRITTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDY6</accession>
    <name>A0A2G1XDY6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25425</name>
        <name evidence="3" type="ORF">CYQ11_20650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49389">
        <property type="protein sequence ID" value="PHQ49389"/>
        <property type="gene ID" value="BLA24_25425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14961">
        <property type="protein sequence ID" value="PPT14961"/>
        <property type="gene ID" value="CYQ11_20650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="181"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="335" mass="35730" checksum="F0788B336BBF9A04" modified="2018-01-31" version="1">MEFTTGGRLEVRISAADVGKRVSVRRLNDSADSPERFTDTVGVLTSWDHGVLRITRRTGQTVEIPEDALVAGKAVPPAPPRRRGPAATLRELQEIAARGWPARETARLGAWTLRAAGGFTTRANSVLPLGDPGLPPSEALDRVTAWYAERGLPACVQVTTGDPAQDERLDAELAGRGWTAERYALMRTAALAPIADAAADTGRVLLGREPDEAWLAAYGRTGADPADATAVLTGGPSVWFATVPAEEPGEGPAAIARCVVDGRWAGFAALHVSPNRRRQGLGTRVMARLARQALDEGASAAYLQVETDNGGAAALYDELGFTTHHAYHYRREPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE19</accession>
    <name>A0A2G1XE19_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S74 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25935</name>
        <name evidence="3" type="ORF">CYQ11_20135</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49480">
        <property type="protein sequence ID" value="PHQ49480"/>
        <property type="gene ID" value="BLA24_25935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14870">
        <property type="protein sequence ID" value="PPT14870"/>
        <property type="gene ID" value="CYQ11_20135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S74" evidence="1">
        <location>
            <begin position="316"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="418" mass="44982" checksum="F3CE6ED160E62746" modified="2018-01-31" version="1">MAITSFPFDSQVVTESQYGYLFREFQDSGVVAAYDSPGFQVSAGNGMVVNVQPGLAILRGHMVQSTAAEALTIPAAGTSTRVDRVVLRLDPASNSITLAVKAGSVGSTAPPALSQTDTGIYEMALANVTVAANVTTITSADVSATRPVVGHRVGVWATSTRPSSPRKGQLGFNNSLARWEWWDGSTWADLAPTVSWASLTGKPSSFWPSVHSHAWGEITEKPTAFPAAEHSHNWDSVVGKPSYFPPTSHGHSWGQISDKPGSYPPSGHSHGEYLTSGSTISWANGSKMPHNNSASGSGTWYAVWVEGDGTFCRNTSSIRYKENVRDIEIDPAAVLALRPRIYDRKPTEGKPQSRKDEYGLIAEEVAATLPEIVTYDEEGRIDALRYDLLGVALLPVVQDQAKRIERLEALVEELARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEC9</accession>
    <name>A0A2G1XEC9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26550</name>
        <name evidence="4" type="ORF">CYQ11_19085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49586">
        <property type="protein sequence ID" value="PHQ49586"/>
        <property type="gene ID" value="BLA24_26550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14695">
        <property type="protein sequence ID" value="PPT14695"/>
        <property type="gene ID" value="CYQ11_19085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="204" mass="20854" checksum="EF24A8D3A132D589" modified="2018-01-31" version="1">MAGMTAQRRLVLASQSPARLGLLRQAGLAPEVVVSGVDEDALDAPTPGELALVLAEAKAAAVAARPAAAGALVVGCDSVLELDGQALGKPADAEEATARWKAMRGRSGVLRTGHCVVDTANGRRASATASTTVRFGEPTDAEIAAYVASGEPLHVAGAFTLDGRSAPFVRGIDGDPGNVIGLSLPLLRDLLAELEVQITDLWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XED3</accession>
    <name>A0A2G1XED3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_26560</name>
        <name evidence="6" type="ORF">CYQ11_19075</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49588">
        <property type="protein sequence ID" value="PHQ49588"/>
        <property type="gene ID" value="BLA24_26560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14693">
        <property type="protein sequence ID" value="PPT14693"/>
        <property type="gene ID" value="CYQ11_19075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="63"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="254" mass="26699" checksum="531281AFE4B9A38F" modified="2018-01-31" version="1">MPQSVDRALDVLDAVAASEGPVPAKALARRLDCGLSTVYELLGTLTARGHLVRTPAGYVLGYRVPSLHHAFQRQMRLADEVQELLVRARRAVGVDTYFSTYRDGDIAVLAGTAAAHPATGGFTPGRDAAAHATAHGKVLLAALPRAARLRYLSAAGMRAITPRTITSPERLDVQLRQVRREGSAVEVEESVPGVACVAVPVPAGPGGALTAISAALPLADFHRRGDRVTEAIRHVAAEAAKFQGTHDISRSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEE3</accession>
    <name>A0A2G1XEE3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)H-quinone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_26580</name>
        <name evidence="6" type="ORF">CYQ11_19055</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49592">
        <property type="protein sequence ID" value="PHQ49592"/>
        <property type="gene ID" value="BLA24_26580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14689">
        <property type="protein sequence ID" value="PPT14689"/>
        <property type="gene ID" value="CYQ11_19055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="6"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="363"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="482" mass="50649" checksum="DB1D6284E9C8657E" modified="2018-01-31" version="1">MEYVTRIVIIGGGPGGYEAALVAAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPPLERAAGVVGVDLGKVNRRVKRLALAQSHDITASVTRAGGRVMRGRGRLEPQQAPDGSRRVVVRAADGTEETLAADAVLIATGAHPREIPDALPDGERILNWTQVYDLEELPEELIVVGSGVTGAEFAGAYQALGSKVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVMARSRAQSAKRVGDRVEVTLADGRVITGTHCLMAVGSIPNTAGIGLEEAGVRLKESGHVWTDKVSRTSAPGVYAAGDCTGVFALASVAAMQGRIAMYHFLGDAVAPLNLKAVSANVFTDPEIATVGYTQADVDNGLIDARVVKLPLLRNPRAKMQGIRDGFVKMFCRPGTGIVVGGVVVSPRASELIHPISIAVDNNLTVEQIANAFSVYPSLSGSIAEVARQLHTRKTQREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEF5</accession>
    <name>A0A2G1XEF5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26780</name>
        <name evidence="4" type="ORF">CYQ11_18855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49624">
        <property type="protein sequence ID" value="PHQ49624"/>
        <property type="gene ID" value="BLA24_26780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14655">
        <property type="protein sequence ID" value="PPT14655"/>
        <property type="gene ID" value="CYQ11_18855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NeuB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="34134" checksum="5015F83119CC83C4" modified="2018-01-31" version="1">MNAAPRSGTRTRLLGDRPVGPGHPVYVTGEIGINHNGDLAKALALVDAAADAGCDAVKFQKRTPEVCTPRDQWDLERETPWGRMTYIDYRHRVEFGEEEYRAVDEHCRKRGIAWFASPWDTESVAFLEKFDLPAHKVASASLTDDELLRALRATGRTVILSTGMSTPQQIRHAVEVLGSENIVLCHATSTYPAKAAELNLRVINTLQAEYPNVPIGYSGHETGLQTTLAAVALGAAFVERHITLDRAMWGSDQAASVEPGGLQRLVRDIRVVEESLGDGVKRVYDSELGPMRKLRRVAGTVAASADREPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI3</accession>
    <name>A0A2G1XEI3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_26905</name>
        <name evidence="5" type="ORF">CYQ11_18730</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49647">
        <property type="protein sequence ID" value="PHQ49647"/>
        <property type="gene ID" value="BLA24_26905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14631">
        <property type="protein sequence ID" value="PPT14631"/>
        <property type="gene ID" value="CYQ11_18730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305499" evidence="2">
        <location>
            <begin position="32"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="409"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="506" mass="54016" checksum="1D045CC50CCD0F74" modified="2018-01-31" version="1">MTLQPRKALLLTLSAAAVATGLGVGPASAGAATPQGRPPTLDWGHCADAPADSSRECATLRVPLDYGKPDGRQVDLAVTRIRSDRPEARRGALLVIAGGPGGSGVAEVAGRGKKLMEATQGMYDIVSLDPRGVGGSTKASCGLSDDDRDLTHLRPWPGPGGDITENVARAKRIADACARNGGELLRSISSTNEVRDIERFRQALGEEKLSAVGRSYGTYVGAVYAQKYPERTDRWVLDSNGDPDPSRVERGWSANMSVGADDRFPDFARWAADPARDSGGKKQRLARTPEEVRPLFLALAAKLDREPRKFADGHLLTGDRLRQNLQQALYDDKSFGALADLILAASRDGAAPVEAPELIPVTIPDTEAAVMIGVLCNDVRWPKSLASYAREVAVDRVRHPLTAGMPVGVMPCAFWKDAPADKPTRITSDGPSNVLMIQNLRDPATPYSGALKMREAFGDRARLVSVDSGGHGAYLKWGNACGDRAVSTFLTTGERPGRDVFCKAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI6</accession>
    <name>A0A2G1XEI6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_26690</name>
        <name evidence="6" type="ORF">CYQ11_18945</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49611">
        <property type="protein sequence ID" value="PHQ49611"/>
        <property type="gene ID" value="BLA24_26690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14669">
        <property type="protein sequence ID" value="PPT14669"/>
        <property type="gene ID" value="CYQ11_18945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="331" mass="35131" checksum="3FFBA6699503D0DD" modified="2018-01-31" version="1">MTNLAIAANGLRKSYGDKVVLDGVDLAVPEGTVFSLLGPNGAGKTTAVKILSTLIRADAGAIRVGGHDLAADPQAVRAAIGVTGQFSAVDGLITGEENMLLMADLHHLPRREGRRTAAELLERFGLTEAAKKPASTYSGGMKRRLDIAMTLVGGPRIIFLDEPTTGLDPRSRHHMWQIVRQLVADGVTVFLTTQYLDEADELADRIAVLDDGKIAAEGTAEELKRLVPGGHVRLRFTDPAAYQGAASALREATLLQGPGSARAGDTPLDESLMLQIPSGGSPRELRSLLDWLDAAGIEAEELTVHTPDLDDVFFALTAGGDVPHQPEEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEP1</accession>
    <name>A0A2G1XEP1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dprA</name>
        <name evidence="3" type="ORF">BLA24_23255</name>
        <name evidence="4" type="ORF">CYQ11_22820</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49690">
        <property type="protein sequence ID" value="PHQ49690"/>
        <property type="gene ID" value="BLA24_23255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16734">
        <property type="protein sequence ID" value="PPT16734"/>
        <property type="gene ID" value="CYQ11_22820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="390" mass="39811" checksum="15D652A578870880" modified="2018-01-31" version="1">MSEGERLARAALTRLTEPGDEAVGRWLRQLGPVDLMRGLTGAGPPPAGARADRLAGCRARAAGLDPAGDLAAAARLGGRFLCPGDHEWPTQLDDLGDARPVGLWVRGSPDVRRWALRSVAVVGARACTGYGSHVAATLGAGLAERGWVVVSGAAYGVDGAAHRGALAAGGATVAVLASGIDVPYPRGHAELLGRVGEQGLVLAELPPGGHPTRSRFVLRNRVIAALTRGTVVVEAELRSGSLVTARRAIELGRHTMGVPGPVTSGLSAGVHELLREGASLVTGAADVIELVGSIGDLAPERRGPVVPRDLLDADAARVLEAVPGRGGAGVAAVAREAGTGAERALAKLYELQALGFVERLGDLWQLADASSTSDTPKPPGRRPGARRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XES2</accession>
    <name>A0A2G1XES2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_24905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 9"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49723">
        <property type="protein sequence ID" value="PHQ49723"/>
        <property type="gene ID" value="BLA24_24905"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ49723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="798" mass="87275" checksum="1A81FF6323045A17" modified="2018-01-31" version="1">MAPADLESGPVSANAEATGGPGTALLRTLTDLTADLPATDPGKVAAAALRGRHPGSDEAELRSLATEAAAGLIAEEPEYSRLAARLLTRAIADEAAGQGATSFSASVEVGHREGLIADETAAFVRTHAARLDALVDAALADGADDRFGYFGLRTLHSRYLLRHPIHRDVIETPQHFLLRVACGLAENHSEQALDDVAELYRLTSTLSYLPSSPTLFNSGTRHPQMSSCYLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVPFLRTLDASVAAVNQGGRRKGAACVYLETWHADIEEFLELRDNTGEEARRTHNLNIAHWIPDEFMRRVEADADWSLFSPADTPDLVDLYGDEFDAAYRAYEAAGKAVKQIPARVLYARMMRTLAQTGNGWMTFKDAANRTANQTAEKGKVVHSSNLCTEILEVTDDGETAVCNLGSVNLAAHLGTDGEMDWEKLDRTVRTAVTFLDRVVDINFYPTEQAGNSNSRWRPVGLGLMGLQDVFFRLRLPFDSAEAKELSTRISERIMLAAYEASADLAERHGPHPAWSATRTARGVLHPDHYPNAVPGWADRWEALRARIGEVGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLSGEFLQVNTYLVEDLKKLGVWDRTTRDAMTDANGSIQDMKWIPQEVRDLYRTAWEIPQRFLIDMAAARTPYLDQSQSLNLFMASPTIGKLSSMYAYAWKQGIKTTYYLRSRPATRIARAASGGAAAPATIPVQQAAPDADAIACSLENPESCEACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEX8</accession>
    <name>A0A2G1XEX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19240</name>
        <name evidence="3" type="ORF">CYQ11_11560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49787">
        <property type="protein sequence ID" value="PHQ49787"/>
        <property type="gene ID" value="BLA24_19240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13437">
        <property type="protein sequence ID" value="PPT13437"/>
        <property type="gene ID" value="CYQ11_11560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="148" mass="16567" checksum="507F1EEF2DA0F3FA" modified="2018-01-31" version="1">MYRTHQPAAHAPRSRGAGAAPPRRGDPRRPAAHRRERELRRPHYWFAERLLLTLSGQRPVHWMLGHTLPAAYDQLAELAPRLPLRPAPPGRSAPVLRGCGHFQPRPGVIEAFARIASGDRLQALAFRLEHGPDRRWRCAAVELAGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF48</accession>
    <name>A0A2G1XF48_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19610</name>
        <name evidence="3" type="ORF">CYQ11_11185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49850">
        <property type="protein sequence ID" value="PHQ49850"/>
        <property type="gene ID" value="BLA24_19610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13374">
        <property type="protein sequence ID" value="PPT13374"/>
        <property type="gene ID" value="CYQ11_11185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="469" mass="48471" checksum="3FC886253820B2E2" modified="2018-01-31" version="1">MGDLTELLREGLPAEAVLTDPDVTGSYGRDMAGFCAAGAPAVVVLPRTVEQVQHVLRTATALRVPVVPQGARTGLSGAANATDGCIVLSLVKMDRILEIDPVERIAVVEPGVVNAVLSRAVAEHGLCYPPDPSSWEQCTIGGNIGTASGGLCCVKYGVTAEYVLGLDVVLADGRLLTTGRRTAKGVAGYDLTRLFVGSEGSLGVVVRAVLALRPAPPAQLALAAEFPSAAAACEAVRQIMARGHAPSLLELMDRTCVQAVNSLAKMGLPETTEALLLAAFDTPDPAPDLAAVAALCTDAGATEVVPAEDAAESDLLLEARRLALPALERLRPATMIDDVCVPRSQLAAMLEGTAAIARAHDLTIGVCAHAGDGNTHPVVCFDPADPDEARRARASFEEIMALGLELGGTITGEHGVGLLKKEWLAREAGPVAMEVQRGIKAVFDPLGLLNPGKVLDVPGDHSIGFPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF83</accession>
    <name>A0A2G1XF83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1697 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_19860</name>
        <name evidence="2" type="ORF">CYQ11_10930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49893">
        <property type="protein sequence ID" value="PHQ49893"/>
        <property type="gene ID" value="BLA24_19860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13331">
        <property type="protein sequence ID" value="PPT13331"/>
        <property type="gene ID" value="CYQ11_10930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="19977" checksum="9899B73DD1D7E5C4" modified="2018-01-31" version="1">MTTKAYAALLRGINVGGHKKVPMAGLRELLTELGHGDVRTYLQSGNAVFTSAVEDEEALAAQLRQAIWERFGFDVGVLVRGHAYLRAVADACPFPAASLEGRQLHVTFFSEPVDAARFASVEAARYAPEEFRLGDRALYLYAPDGLGRSKLAEVLTRATPAKSGIVATSRNWNTVVKLVEWTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB1</accession>
    <name>A0A2G1XFB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19850</name>
        <name evidence="4" type="ORF">CYQ11_10940</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49891">
        <property type="protein sequence ID" value="PHQ49891"/>
        <property type="gene ID" value="BLA24_19850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13333">
        <property type="protein sequence ID" value="PPT13333"/>
        <property type="gene ID" value="CYQ11_10940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="193" mass="20886" checksum="AAF5FF28163AB6BC" modified="2018-01-31" version="1">MPSSGPRERDPRSGRLNDQEFRVSSFFLAAGTDLITDRLALRPWSADEIATVVGDGRSAHWAEDFPAEGDRVIAGFIGAQADPSSEHAHRQIVERDSGLVVGSISLLWPPSDGRVEFGYGVVPSRRGRGYAPEAARALVAYALASPNVHTVYADVELANPASVRVLEKAGLERRSSDDVTARFRAVTPEPHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFL7</accession>
    <name>A0A2G1XFL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20535</name>
        <name evidence="4" type="ORF">CYQ11_10245</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50001">
        <property type="protein sequence ID" value="PHQ50001"/>
        <property type="gene ID" value="BLA24_20535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13221">
        <property type="protein sequence ID" value="PPT13221"/>
        <property type="gene ID" value="CYQ11_10245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="219"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="859" mass="90658" checksum="A76B0BCC890C4695" modified="2018-01-31" version="1">MNGTSCQRQDCAGSYEDVGGGELYCDVCGLAPVVSPGGRLSSPATGVTRPGGRGGAVAEGQVGPGSGRSSSGSGSGSSSGPSRRGSAGSGRSSRSSGSRRSVSGRLSLSASADTEGTGPPSVSVRSGRQSTGGSSGRHRLGAGLVAMPGVPRPDPRTAVLADPEVPERKRFCSRSDCGAAVGRARGDRPGRVEGFCTKCGHPYSFVPKLHPGDVVHGQYEVAGCLAHGGLGWIYLAIDRAVSDRWVVLKGLLDTGDEDALAAAVSERRFLAEIEHSNIVRIYNFVEHLDQRTGSLDGYIVMEYVGGKSLKEIANDRRAPDGRRDPLPVEQACAYGIEALEALAHLHSRNLLYCDFKVDNAIQQQDQLKLIDMGAVRRMDDHDSPIYGTVGYQAPEVAEVGPSVASDLYTVARTLAVLTFDFQGYTNVFAASLPDPGHIEVFGRYESFYRLLVRATDPDPARRFASADEMAEQLTGVLREIVALQTGTPRPALSTLFGPEPKVVDTALFRARTDDVSALGARVTSRRARGAAAAPAAGPVPAGGAAAVAVAPLDARAAALALPLPRVDADDPNAGFLAGLLASQPAELDAALRAAPVDSPELRLRRVRARLELGEDEPAAQTLAALEAARPDDWRTIWYRGVHALATGDHERAALSFDAVYDAFPGEPAPKLALGVCAETLGQLDNAAEYYRLVWSTDPGFVSAAFALARVRLAAGDRAGGVSALESVSEASIHYTAARIAAVRARLRQRSPREARLGDDLRAAAGQVERLADFGLDAVRREQLATEVLGTALDWVLSGGGTAGGAPPDSGPLLGSALDERGLRFGLERSYRVLARLAQRGEERIELVERANRYRPRTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFR3</accession>
    <name>A0A2G1XFR3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21020</name>
        <name evidence="2" type="ORF">CYQ11_09765</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50080">
        <property type="protein sequence ID" value="PHQ50080"/>
        <property type="gene ID" value="BLA24_21020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13139">
        <property type="protein sequence ID" value="PPT13139"/>
        <property type="gene ID" value="CYQ11_09765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="8816" checksum="90A6EAA6ED8E920E" modified="2018-01-31" version="1">MGAHSRKCDWCGSGTPIVRDMEPLNSAFQYWCVECARALIIKGDPIETYRELEGEPIYGRLLDEHCTLKRFYSFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFR7</accession>
    <name>A0A2G1XFR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21035</name>
        <name evidence="3" type="ORF">CYQ11_09750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50082">
        <property type="protein sequence ID" value="PHQ50082"/>
        <property type="gene ID" value="BLA24_21035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13137">
        <property type="protein sequence ID" value="PPT13137"/>
        <property type="gene ID" value="CYQ11_09750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7504" checksum="C7FEAAABEC76AB01" modified="2018-01-31" version="1">MRGGHLGGGGGLAHRPLSSIDRRLCLRLRCSGISRYLRRAFPGNEKSPRTGGDAAPMPAGSHRPVLISAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS2</accession>
    <name>A0A2G1XFS2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Arylamine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21065</name>
        <name evidence="4" type="ORF">CYQ11_09720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50088">
        <property type="protein sequence ID" value="PHQ50088"/>
        <property type="gene ID" value="BLA24_21065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13132">
        <property type="protein sequence ID" value="PPT13132"/>
        <property type="gene ID" value="CYQ11_09720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="28980" checksum="6CEFE10E1818FDA5" modified="2018-01-31" version="1">MDSTETDAYLHRIGAARPAAADAAALRDLHLRHLKTVPFENLSIHLGEEIVLDPGALLDKVVRGGRGGFCYELNGLFAELLTALGYRVTLLAGRVVGPDGEFGIPFDHLALRVETAGAGAPEAWLVDVGFGRNSHHPLKLAERGEQSDPAGLFRIAETEEGDLDVIKDGAVQYRLEQRRRELGDFEAGAWWHRTSEKSPFTRSPLCSLLTGTGRVTISGRTLVTTAAGGRGRQERTLADDELLPAYREHFGIVIDRLPGRTEGGPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFS3</accession>
    <name>A0A2G1XFS3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="9" type="ORF">BLA24_21080</name>
        <name evidence="10" type="ORF">CYQ11_09705</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50090">
        <property type="protein sequence ID" value="PHQ50090"/>
        <property type="gene ID" value="BLA24_21080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13130">
        <property type="protein sequence ID" value="PPT13130"/>
        <property type="gene ID" value="CYQ11_09705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="88" mass="9127" checksum="5185BB3C7A714452" modified="2018-01-31" version="1">MANIKSQMKRNKTNEKARLRNKAVKSEVKTFVRAAREALAGGDTAKAAAAVALAGKKLDKAASKGVLHKNAAANKKSALAKQAAALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFU8</accession>
    <name>A0A2G1XFU8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20955</name>
        <name evidence="4" type="ORF">CYQ11_09825</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50071">
        <property type="protein sequence ID" value="PHQ50071"/>
        <property type="gene ID" value="BLA24_20955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13148">
        <property type="protein sequence ID" value="PPT13148"/>
        <property type="gene ID" value="CYQ11_09825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="680" mass="73167" checksum="9E8C96055C1B1CCD" modified="2018-01-31" version="1">MPSAGTASRRAVQLAALLAMLVFFAAQLVGALLPLVPLLISASAAGLALDLYLQHRDPGLVAVLGKIRFDVMVRQLLRDMLVLIGLVRLNGDDSLRGYVPVVAGLVLFYAAHLACQATAILVRRSRTLPFLTRNIDASGLRLTAAPPRLLARQHGRRLLRFAVPATAGLLVTAGTHRALWAEIGVGAAVVLALGGTAYLAGWLRPKKRVANEQQALQWLDKWLAAYQPTVGMYFSGGTTSAYQANMWLSTLAELDGNPVIVLRERFMMQKIEATDVPIVCIPKVVHLMALEKSSLKMMLHPANSGKTSQVLRMPSIKHAFINHGESDKLSSCNPYSKAYDEVWVAGPAARERYQLADIGVEDKDVVEVGRPQLAPILPYTGAPTGDYTTVLYAPTWEGWDGNPGNTSVMLAGENVVRALLADPKVRLLYKPHPMTGSVDPRAGRANERIQAMIREANAARSGARPDAAAAAELARRTTELDRLTTSGFRESADEVERMMLQGTPEKGRAATVEAATAAWEAAYWASLPEWEHQIITDARPALFSCFNQADLLISDVSSVVSDYLISEKPYSVANTSGMSEEEFRASFPTVSAATILTPEAAGVPGLLAAVRDPSLDGLAPARAELKVQLLGPADPPSLVRFNAAALALAAKADERRARMEARASEIPAPRFGDAEETVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG33</accession>
    <name>A0A2G1XG33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF475 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21715</name>
        <name evidence="3" type="ORF">CYQ11_09070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50193">
        <property type="protein sequence ID" value="PHQ50193"/>
        <property type="gene ID" value="BLA24_21715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13023">
        <property type="protein sequence ID" value="PPT13023"/>
        <property type="gene ID" value="CYQ11_09070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04332">
        <property type="entry name" value="DUF475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="40466" checksum="E172DFC699D3BF1D" modified="2018-01-31" version="1">MLLKTFGWSFAITAAGLALAGVLWGWQGLAIVAILSVLEISLSFDNAVINAGILRKMNAFWQRIFLTVGILIAVFGMRLVFPVVIVAITAKLGPIEAVDLAINNKDRYEELVTAAHPAIAAFGGMFLLMIFLDFIFEDRDIKWLDWLEKPLARLGKLDTLSTVVSLVVLLVAATTLATAVPVHGGDGTVDKAATVLLAGIGGLVTYLIVGGVSGFFEDRLEQEEEEAEEEAEKAPAKSGGGSVVGLAGKAAFFMFLYLEVIDASFSFDGVIGAFAITNDIFIMALGLGIGAMYIRSLTVFLVRKGTLDDYVYLEHGAHYAIGALAVILLITIKYEIKEVVTGLVGIVLIGLSFLSSVRRNRREAEAGGDSGAKAEVSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG54</accession>
    <name>A0A2G1XG54_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_21270</name>
        <name evidence="13" type="ORF">CYQ11_09515</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50119">
        <property type="protein sequence ID" value="PHQ50119"/>
        <property type="gene ID" value="BLA24_21270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13100">
        <property type="protein sequence ID" value="PPT13100"/>
        <property type="gene ID" value="CYQ11_09515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="437" mass="46905" checksum="AF93BBDCB29B22A8" modified="2018-01-31" version="1">MTGQLITAAVLLLVVAWLAACAEAGLARTTRFRAEEAVRSGRRGGARLMAVAADPTRYLNLALLVRVACEMAAGVFVTYVCLEEFDATWQALTVAVAVMVLVSYVAVGVSPRTIGRQHPLGTATAAAYVLLPLARVLGPVPRLLILIGNALTPGKGFRMGPFASEAELRAMVDLAEKESLIEDDERRMVHSVFELGDTLVREVMVPRTDLVVIERGKTIRQALTLALRSGFSRIPVTGENEDDIVGVVYLKDLARKTHISRDAEAELVSTAMRPAVFVPDTKNAGDLLREMQQQRNHCAVVIDEYGGTAGIVTIEDILEEIVGEITDEYDRELPPVEELGEGRYRVTARLDLGDLGELYGLELDDEDVETVGGLLAKSLGRVPIAGAMAEVPVPLVDQGGPAPSPATLRLTAESAAGRRNRIVTVLVEPVDGPGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGL3</accession>
    <name>A0A2G1XGL3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19950</name>
        <name evidence="3" type="ORF">CYQ11_10840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50367">
        <property type="protein sequence ID" value="PHQ50367"/>
        <property type="gene ID" value="BLA24_19950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16484">
        <property type="protein sequence ID" value="PPT16484"/>
        <property type="gene ID" value="CYQ11_10840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="144" mass="15183" checksum="CAF30497BC68F5DD" modified="2018-01-31" version="1">MTATEAPRESLATAAGDPAIKPLPTWFFGFEGMMSAAYDLFKAYPQSLWVLGALGVVNIVASLTVLRSRLQLAKRLWRGKSTRKLAVGLVALRLGSHAVLTAAGLAVTSTAGHLGFAVVMAATTVSLLWFAQRTALRAVADGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX6</accession>
    <name>A0A2G1XGX6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">BLA24_16770</name>
        <name evidence="11" type="ORF">CYQ11_16515</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50490">
        <property type="protein sequence ID" value="PHQ50490"/>
        <property type="gene ID" value="BLA24_16770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14255">
        <property type="protein sequence ID" value="PPT14255"/>
        <property type="gene ID" value="CYQ11_16515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="797" mass="81256" checksum="112F7B118D72E774" modified="2018-01-31" version="1">MAGPLTPEQVDSTQRLAVELTSGNRTLIMVIAVVAVAALAVAVVLVRQVLSAGEGTDRMKEIAAAVQEGANAYLARQLRTLGVFAAIVFFLLMLLPADNWSQRAGRSVFFLVGALFSAATGYIGMWLAVRSNVRVAAAAREATPAEGEPEKDLTAVSHKAMKIAFRTGGVVGMFTVGLGLLGASCVVLVYAADAPKVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGKAAFGDSGLAFPLLVPAIGVITAMIGIFAVAPRRSDRSGMSAINRGFFISAVISLVLVAVAVFAYLPSDYADLKGITDETVRGHDGDPRVLALVAVAIGIVLAALIQQLTGYFTETSRRPVRDIGKTSLTGPATVVLAGISVGLESAVYSAVLIALAVYGAFLLGGTSIMLALFAVALAGTGLLTTVGVIVAMDTFGPVSDNAQGIAEMSGDVEGAGAQVLTDLDAVGNTTKAITKGIAIATAVLAASALFGSYRDAIATAVQDVHAKSGEMGLSLDISQPNNLVGLVLGAAVVFLFSGLAINAVSRSAGSVVYEVRRQFREHPGIMDYTEKPEYGRVVDICTKDALRELATPGLLAVMAPIAVGFSLGVGALGSYLAGAIGTGTLMAVFLANSGGAWDNAKKLVEDGHHGGKGSEAHAATVIGDTVGDPFKDTAGPAINPLLKVMNLVALLIAPAVVKFSYGADASRGVRIGVAALAIVVIVAAVYVSKRRGVAVDGDDGNAERAAKPVDPAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH47</accession>
    <name>A0A2G1XH47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17155</name>
        <name evidence="2" type="ORF">CYQ11_16120</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50545">
        <property type="protein sequence ID" value="PHQ50545"/>
        <property type="gene ID" value="BLA24_17155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14201">
        <property type="protein sequence ID" value="PPT14201"/>
        <property type="gene ID" value="CYQ11_16120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7330" checksum="CCB4CD8A86FCDC12" modified="2018-01-31" version="1">MKGRHARDDSPIDLSHPARMVLALLALGLAAPGAILGRHVATGYLVAGNQAHTLDPAKATVVTVPDARPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH62</accession>
    <name>A0A2G1XH62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_17320</name>
        <name evidence="9" type="ORF">CYQ11_15955</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50573">
        <property type="protein sequence ID" value="PHQ50573"/>
        <property type="gene ID" value="BLA24_17320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14173">
        <property type="protein sequence ID" value="PPT14173"/>
        <property type="gene ID" value="CYQ11_15955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="32"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="548" mass="57076" checksum="9EAEB139191FC8FB" modified="2018-01-31" version="1">MAKSTPAGVRDASGASASTEAAPMSHRQIMEALSGLLLGMFVAILSSTIVSNALPEIIHDLHGSQSSYTWVVTASLLAMTASTPLWGKLSDLFSKKLLVQIALVVYVAGSIVAGLSQNTSMLIACRVVQGIGVGGLSALAQIVMAAMISPRERGRYSGYLGATFAVATVGGPLLGGVITDTDWLGWRWCFYVGVPFAIIALIVLQKTLKLPVVKRNVKVDWLGAFFITASVTLLLIWVTRAGKDYDWLSWQTYAMVGGSVLLAALFLLAEAKAAEPIIPLRLFRNKTIALSSLASLFVGVAMFAGTVFFSQYFQLARGESPTMSGVLTIPMIGGLFVSSTVSGQIITKTGRWKAWLLSGGVLLTAGLGLLGTMRYDTPYWHLAVYMALTGLGIGMMMQNLVLAAQNQVEPKDLGAASSVVTFFRSLGGAVGVSALGAVLANKVPDYVKEGLTALGPKAAAAMGHGGAGGGGIPDLDKLPAPLRTVMESAYGHGIGDVFLYAAPCALIAFIVTLFIKEVALKGNGAPRATASDPASATADAGEPARQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH73</accession>
    <name>A0A2G1XH73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17485</name>
        <name evidence="4" type="ORF">CYQ11_15790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50594">
        <property type="protein sequence ID" value="PHQ50594"/>
        <property type="gene ID" value="BLA24_17485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14151">
        <property type="protein sequence ID" value="PPT14151"/>
        <property type="gene ID" value="CYQ11_15790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="27628" checksum="9A403A9497955D86" modified="2018-01-31" version="1">MREILGRRRKLSLRRAGRSAVLTAALTYATEWQWPVLPGVALRPGIGRGRECACPDPDCAVPGAHPFDPGLLAATTDARMVRWWWTNRPEAPVVLATGGRAPCAVSLPAVAGARALAAFDRAGVRLGPVVATPSRWSLLVAPYSLEVLGELLHRQDWVPGSLRFHGEGGYAVLPPSPTGAGRVRWERAPRPAGAAGTRGGSSGSGERSRVDRWTERRGDRRVDGLARPWLPDVATVIDVLVEQSASTGSGSPGGGNKLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHX9</accession>
    <name>A0A2G1XHX9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18885</name>
        <name evidence="5" type="ORF">CYQ11_14395</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50827">
        <property type="protein sequence ID" value="PHQ50827"/>
        <property type="gene ID" value="BLA24_18885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13915">
        <property type="protein sequence ID" value="PPT13915"/>
        <property type="gene ID" value="CYQ11_14395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SCP_3" evidence="3">
        <location>
            <begin position="165"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="27331" checksum="B01784AF55143981" modified="2018-01-31" version="1">MAPRPRTYHHTKTRAAVTAQLQNLRAAVEALGEEQFGLPTGVDGRTVSELVAATAETVALVDRYLEQPAPPAREITATEWPSTTRPAAGEPAAETAAAAATDPRAPLGRAASRFAELTAVAPADRLLATPFGAMRLDDFLVTRCVELVVHTDDLATALGVEIPYDRQALATATRLLADALAARAPGGSVEVRIPPFAVVQCVEGPRHTRGTPPNVVETDPLTWIRLAAGRIEWSDAVERASVTASGERADISAQLPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHY2</accession>
    <name>A0A2G1XHY2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_18715</name>
        <name evidence="15" type="ORF">CYQ11_14565</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50801">
        <property type="protein sequence ID" value="PHQ50801"/>
        <property type="gene ID" value="BLA24_18715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13941">
        <property type="protein sequence ID" value="PPT13941"/>
        <property type="gene ID" value="CYQ11_14565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ50801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT13941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="340" mass="36813" checksum="C972CBC11BC0A4C4" modified="2018-01-31" version="1">MPIATPEIYNEMLDRAKAGKFAYPAINVTSTQTLHAALRGFAEAESDGIIQISTGGAEFLGGQYSKDMVSGAVALAEFAHVVAKKYPVNIALHTDHCPKDKLDGYVRPLLAISQERVAAGQNPLFQSHMWDGSAEKLDENLAIAKELLAEAVKAKIILEVEITPTGGEEDGVSHEINDDLYTTVADVERTAEALGLGEKGRYLLAASFGNVHGVYKPGNVVLKPELLRELQDGIAAKHGKADPFDFVFHGGSGSTEEEIRTALENGVVKMNLDTDTQYAFTRPVADHMFRHYDGVLKIDGEVGDKKTYDPRSWGKLAEAGMAERVTRACADLRATGTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG7</accession>
    <name>A0A2G1XIG7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">BLA24_14790</name>
        <name evidence="8" type="ORF">CYQ11_13280</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51044">
        <property type="protein sequence ID" value="PHQ51044"/>
        <property type="gene ID" value="BLA24_14790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13733">
        <property type="protein sequence ID" value="PPT13733"/>
        <property type="gene ID" value="CYQ11_13280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ51044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19104" checksum="E82A6C9CCFBC0409" modified="2018-01-31" version="1">MSRIGRLPIQVPAGVDVTIDGRTVHVKGPKGSLTHAVSAPIEIAKGEDGTLVVSRPNDERQNKALHGLSRTLVANMITGVTQGYSKALEISGVGYRVQAKGSNLEFSLGYSHPILVEAPEGITFKVESPTKLSVEGIDKQKVGEVAANIRKLRKPDPYKAKGVKYAGEVIRRKVGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIM8</accession>
    <name>A0A2G1XIM8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15130</name>
        <name evidence="2" type="ORF">CYQ11_12940</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51104">
        <property type="protein sequence ID" value="PHQ51104"/>
        <property type="gene ID" value="BLA24_15130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13672">
        <property type="protein sequence ID" value="PPT13672"/>
        <property type="gene ID" value="CYQ11_12940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="33105" checksum="4664A2EDBE538D6A" modified="2018-01-31" version="1">MPLPAEFHEIAKRVNNWGRWGEGDERGTLNLITDEVVCAAARTVASGRRVPLALPLQQDGVQTGMIPGRVNPLHTMVAINLEMFGPDTVATSDDTVTMGLQAGTHWDGLCHVSHGGRLYNGRPADSITGHGRAAFNGVEKAGPIVSRGVLLDVARARNVHRLDDDHAVTPEDLEAAEELAGITVRSGDIALVRTGQIQRYLTGDKHAYAHPSPGLSIRTPEWFHARDVAAVANDTLTFEIIPPEIEGLWLGVHALDLVEMGMPQGQNWNLEGLSEVCAEEGRYAFLLSAMPEPFVGATGTPVAPVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIP4</accession>
    <name>A0A2G1XIP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor ShbA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_15060</name>
        <name evidence="9" type="ORF">CYQ11_13010</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51093">
        <property type="protein sequence ID" value="PHQ51093"/>
        <property type="gene ID" value="BLA24_15060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13684">
        <property type="protein sequence ID" value="PPT13684"/>
        <property type="gene ID" value="CYQ11_13010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="23878" checksum="DAACF268CEE3F11B" modified="2018-01-31" version="1">MTAGAPAHNASVHNYGRGAADDAASRHHGPMRDDDTTAIAALVARAVEGDRRATHDLLALVHPLALRYCRTRLSRLPGDARHFVDDLAQEVCLAVLCALPRYRDTGRPFEAFVVAIAAHKVADLQRAAMRHPGSTAVPSDEMPEQPDDSLGPEERALLSSDAEWAKKLLANLPENQRELVLLRVAVGLTAEETGQMLGMSPGAVRVAQHRALSRLRALAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIQ2</accession>
    <name>A0A2G1XIQ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rplA</name>
        <name evidence="11" type="ORF">BLA24_14645</name>
        <name evidence="12" type="ORF">CYQ11_13425</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51019">
        <property type="protein sequence ID" value="PHQ51019"/>
        <property type="gene ID" value="BLA24_14645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13758">
        <property type="protein sequence ID" value="PPT13758"/>
        <property type="gene ID" value="CYQ11_13425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="25591" checksum="4C9E0F4A23EFD6B7" modified="2018-01-31" version="1">MKRSKTLRAADAKLEKERLYAPLEAVRLAKETSATKFDATVEVAFRLGVDPRKADQMVRGTVNLPHGTGKTARVLVFATGDRAEAARAAGADIVGADELIDEVAKGRLDFDAVVATPDLMGKVGRLGRVLGPRGLMPNPKTGTVTPDTAKAVTDIKGGKIEFRVDKHSNLHFIIGKVSFDDAKLVENYAAALEEILRLKPSAAKGRYIKKATLTTTMGPGIALDSNRTRNLLVEDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIT6</accession>
    <name>A0A2G1XIT6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclohexanecarboxylate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15105</name>
        <name evidence="4" type="ORF">CYQ11_12965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51101">
        <property type="protein sequence ID" value="PHQ51101"/>
        <property type="gene ID" value="BLA24_15105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13676">
        <property type="protein sequence ID" value="PPT13676"/>
        <property type="gene ID" value="CYQ11_12965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="445"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="534" mass="57227" checksum="0568FD21C0547755" modified="2018-01-31" version="1">MEPGTPEELAGSPTLWELLDRRATLTPGATALIQADEPARLPDRRMPPQPVSATDRRLTFGELRTRAERVAAWLHTLGVRAGSRVVWQLPTRIETVVLTFALARLGAVQIPVIPSGRDREVGHALRATGAEFFAVPGVWRGFDHGLMAHRLALSLPVPPLVFTAYEDIPEADPAPLPPPPSDGTAVRWVHWTSGTTSDPKGVLHTDRSLIVSGACLADALGLTPDDVGSMAFPYAHVAGPDYTVMVLLRGCPALLVEHFALPDSLGAYRRHGVTVAGGSTAFYSMFLAAQREEPDRRLLPTLRLLAGGGAPRPPGLYHDVVRELGCELVHGYGMTEAPMITMGRPGDPADRLATTEGRPPAGMEIRVVGSEGDTVPAGTDGEIRLRGEAVCQGYLDPSATAEAFDAEGCLRTGDLGHLTEDGYLVLTGRIKDVIIRKGENISAQEVEQLLHSHPGVDDVAVIGLPDAERGERVCAVVQQPAGAPPLTLVEVAAHLEAAGLARHKIPEQLELVGSLPRNDTLRKVLKHKLRERFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIV8</accession>
    <name>A0A2G1XIV8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_15510</name>
        <name evidence="9" type="ORF">CYQ11_12565</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51167">
        <property type="protein sequence ID" value="PHQ51167"/>
        <property type="gene ID" value="BLA24_15510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13610">
        <property type="protein sequence ID" value="PPT13610"/>
        <property type="gene ID" value="CYQ11_12565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ51167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="336" mass="37118" checksum="87185CD12D9E5954" modified="2018-01-31" version="1">MATRAVARRQSAAQGAAADEASSVRAAGGEIADRDLVGMYLDEIARTPLLDAAKEVELSQTIEAGVYAQQILDGLEDGGAKAGEASREELEAIADEGARAKDVFIKSNLRLVVAVARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYTKGFKFSTYATWWIRQAITRSIADQSRTIRLPVHLVEELGRIRRVQREFNREHGREPEHAEIAAELDTTPERVGDVLDWARDPVSLNMSVDDEGETQFGDLLEDTSAVSPEQSVIALLRSEELEGLIGRLDHRTASIIKARYGIEDGRERTLTEVGKQHGLTRERIRQIEKHALLELKKMAHDTGFDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ33</accession>
    <name>A0A2G1XJ33_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tam</name>
        <name evidence="3" type="ORF">BLA24_15880</name>
        <name evidence="4" type="ORF">CYQ11_12195</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:14969"/>
            <dbReference type="ChEBI" id="CHEBI:15708"/>
            <dbReference type="ChEBI" id="CHEBI:57470"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.144"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Tam family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51233">
        <property type="protein sequence ID" value="PHQ51233"/>
        <property type="gene ID" value="BLA24_15880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13543">
        <property type="protein sequence ID" value="PPT13543"/>
        <property type="gene ID" value="CYQ11_12195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00560">
        <property type="entry name" value="Tran_acon_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023506">
        <property type="entry name" value="Trans-aconitate_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="29981" checksum="861D2DDBAEBA7C01" modified="2018-01-31" version="1">MPCAPTPLWDPRQYLRHAEDRSRPFTDLLARVPALPGQGRRPARIADLGCGAGNVTALLAERWRDARVTGYDNSAAMLREADAYAGRTLGGGSIAFARADLTDWSPDPAEPLDLIVSNAAFQWVPGHAGRFPVWLAGLAAGGTFAFQVPGNGDAPSHALLRQLCASVRWRDRLGEAGRRRVEVLDPAQYLARLTDLGCEVDTWETTYAHLLPGEDPVLDWVKGTGLRPVLTALAGDLAATQAFLAEYGALLREAYPAGPGGTVFPFRRVFVVARKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ34</accession>
    <name>A0A2G1XJ34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_15890</name>
        <name evidence="11" type="ORF">CYQ11_12185</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51235">
        <property type="protein sequence ID" value="PHQ51235"/>
        <property type="gene ID" value="BLA24_15890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13541">
        <property type="protein sequence ID" value="PPT13541"/>
        <property type="gene ID" value="CYQ11_12185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="334" mass="37446" checksum="44431F54E63E4954" modified="2018-01-31" version="1">MTASPDVLEDAPKAQEGSLPSATLGGEHRRSVEQITLLMFIVVPFIALLAAVPLAWGWGVSWLDLALMVAMYYIGCHGITIGFHRYFTHGSFKAKRPLRIALAVMGSLAVEGPLVRWVADHRRHHKFSDAEGDPHSPWRYGESVPALMKGLWWAHVGWMFDEEQTPQQKYAPDLIKDPAIRAISRQFVLWTTLSLLIPPLVGGLVTWSWQGALSAFFWGSLVRVALLHHVTWSINSICHAVGKRPFKSRDRSGNVWWLAVLSCGESWHNLHHADPTSARHGVLRGQLDSSARIIRWCEKAGWAYDVRWPNESRIEGRLRAPEASPEKEDAAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ72</accession>
    <name>A0A2G1XJ72_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16130</name>
        <name evidence="4" type="ORF">CYQ11_11945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51273">
        <property type="protein sequence ID" value="PHQ51273"/>
        <property type="gene ID" value="BLA24_16130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16505">
        <property type="protein sequence ID" value="PPT16505"/>
        <property type="gene ID" value="CYQ11_11945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="9"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="385" mass="38827" checksum="10605B3FF884D787" modified="2018-01-31" version="1">MRVLREGVDVVVVGGGIIGAACAEALSRRGVRVLVLDRGPLAGATTARGEGRLLVSDKAPGAGLALARAALRRWPVLLAALREEIGSRAACEFAPQGGLVVATREAEATALRDLAAAQRAAGVTAVDLTPEEAAGYEPRLTPAVRAAVRYPEDARLQPVLAATALLAAVRARGGEVRSGVGVLGVETGADGWVVGVRTAQGQVPCVAVVNACGTGAAALARQARVPLPVPSRPATTLVTAPLPLGTVRHQVSGAGPAPVSVGPSPAGPVLIGRTGPVPRGGVPRAEVLAGLARGATALFPALADVPVLRVHDGLCACTRDRLPVIGEDPRRPGLWHATGHAGAGAGLAAATGELLAQLFTGEPPLLDPRPYRVDRPGLGEEDGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ84</accession>
    <name>A0A2G1XJ84_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional F420 biosynthesis protein FbiB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Coenzyme F420:L-glutamate ligase</fullName>
                <ecNumber evidence="10">6.3.2.31</ecNumber>
                <ecNumber evidence="10">6.3.2.34</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Coenzyme F420-0:L-glutamate ligase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Coenzyme F420-1:gamma-L-glutamate ligase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Dehydro-coenzyme F420-0 reductase</fullName>
                <ecNumber evidence="10">1.3.8.17</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">fbiB</name>
        <name evidence="14" type="ORF">BLA24_16365</name>
        <name evidence="15" type="ORF">CYQ11_11710</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2</text>
            <dbReference type="Rhea" id="RHEA:60360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="1.3.8.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57922"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Monovalent cation. The ion could be potassium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the CofE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="10"/>
    <dbReference type="EC" id="6.3.2.34" evidence="10"/>
    <dbReference type="EC" id="1.3.8.17" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51312">
        <property type="protein sequence ID" value="PHQ51312"/>
        <property type="gene ID" value="BLA24_16365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13462">
        <property type="protein sequence ID" value="PPT13462"/>
        <property type="gene ID" value="CYQ11_11710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052890">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01259">
        <property type="entry name" value="F420_ligase_FbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019943">
        <property type="entry name" value="F420_FbiB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023661">
        <property type="entry name" value="FbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03553">
        <property type="entry name" value="F420_FbiB_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="13">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="F420_ligase" evidence="13">
        <location>
            <begin position="117"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="12">
        <location>
            <begin position="280"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme F420:L-glutamate ligase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydro-coenzyme F420-0 reductase" evidence="10">
        <location>
            <begin position="269"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>coenzyme F420-(gamma-Glu)n</name>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ51312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="468" mass="48931" checksum="DFA2198C7CC7B87E" modified="2018-01-31" version="1">MPGGAADDDRRRGDGGDGPPGAGPRRGGARVSALPSYRVWAVPGIPEVRPGDDLVKLIAVAATADGLPGLTDGDVLVVTSKIVSKAEGRVVAATDREAAIDDETVRLVARRGALRVVENRLGLVMAAAGVDASNTAAGTVLLLPEDPDASARRIRDGLREALGVDVGVVVTDTAGRPWRKGVTDFAIGAAGVQVANDLRGDVDAHGNPLVATVVATVDELAAAGDLVKGKAGALPVAVVRGLPHVVGSTDEGARWLVRPAEDDMFRLGTSEAVREAVAIRRTVREFTDDPVDPGAVRRAVAAAVTAPAPHHTTPWRFVLLESEAARTELLDAMRDAWVADLRADGRSEESVAKRVRRGDLLRKAPYLVVPCLVTDGSHDYPDARRSAAEREMFVVSAGAAVQNFLVALAGERLGSAWVSSTMFCRNVVRRVLDLPEGWDPMGAVAVGRPAAAPAARAPRSADAFVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJC9</accession>
    <name>A0A2G1XJC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_03505</name>
        <name evidence="6" type="ORF">BLA24_14485</name>
        <name evidence="8" type="ORF">CYQ11_13590</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000044">
        <property type="protein sequence ID" value="PHQ53103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51336">
        <property type="protein sequence ID" value="PHQ51336"/>
        <property type="gene ID" value="BLA24_14485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53103">
        <property type="protein sequence ID" value="PHQ53103"/>
        <property type="gene ID" value="BLA24_03505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16541">
        <property type="protein sequence ID" value="PPT16541"/>
        <property type="gene ID" value="CYQ11_13590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18841" checksum="1BA3C031F53DBF15" modified="2018-01-31" version="1">MTRRSRTAQYPEVQPQLPPRTRGVIGLFEENCTVCMLCARECPDWCIYIDSHKETMPPAAPGGRERSRNVLDRFAIDFSLCMYCGICIEVCPFDALFWSPEFEYAETDIAELTHERDKLREWMWTVPEPPALDPAAEEPKEIAAARKTAEKLAAQAQEQEKEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJL6</accession>
    <name>A0A2G1XJL6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_13860</name>
        <name evidence="7" type="ORF">CYQ11_01555</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51454">
        <property type="protein sequence ID" value="PHQ51454"/>
        <property type="gene ID" value="BLA24_13860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16284">
        <property type="protein sequence ID" value="PPT16284"/>
        <property type="gene ID" value="CYQ11_01555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="526" mass="55479" checksum="00369EDFC262FD3B" modified="2018-01-31" version="1">MRAGARLLLSGVSFTVSPGDRIGLVGRNGAGKTTLLTALAGRSRPAAGTITRTGPVGFLAQDSRPADPAVTVTDRILSARGLDRALNRLRTAEAAMADADGPAALARAMNAYSRAEAAFQAGGGYAAEAEAARVAAGLGLPDRALGEPVGSLSGGQRRRVELARILFAGHDGTLLLDEPTNHLDADAVSWLRTFLRGHQGGFVVISHDTALLSDVVGGVFHLDPQRATIDVHHTGWHAYLAQREADERRRARERANAERKAAALHAQADKMKARAATAVTARSMARRADRMLAALEPARRTDKVAKIRLPEPAPCGRIPLGAVSLAKAYGGRQVLSGVDLAVDRGSRLVVLGLNGAGKTTLLRLLAGEERPDAGRVVHGHGLRLGYFAQEHDTLARERTVRQNMTAAAPHLTDGEVRQVLGAFLFTGDDAEKPAGVLSGGEKTRLALAGLVHSGANVLLLDEPTNNLDPASRDEVLAAVGSYPGAIVMVTHDEGAVDALRPDRVLLLPDADEDLWSEDYRDLVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJQ5</accession>
    <name>A0A2G1XJQ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14000</name>
        <name evidence="3" type="ORF">CYQ11_01695</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51440">
        <property type="protein sequence ID" value="PHQ51440"/>
        <property type="gene ID" value="BLA24_14000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11781">
        <property type="protein sequence ID" value="PPT11781"/>
        <property type="gene ID" value="CYQ11_01695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017208">
        <property type="entry name" value="UCP037442_abhydr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037442">
        <property type="entry name" value="UCP037442_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="32852" checksum="12ABBB5D3E2C5FA8" modified="2018-01-31" version="1">MRPPRFPVLAGITAPDGARLTVRALAHEDPTTPVVVLLPAMGMAARHYTPLVRTLHRRGMTVVTTDLRGHGESRPLPGRGVGFGYREIVEHDVGAVLRRVREAFPHAPVLLLGHSLGGQLGLVHCGLYQPDVAGVVLVATGSAWYRCFGPLAGPRWLLLSQLYAAGAALLGYWPGERLGFAGRESARLIRDWARQVRTGRYEVPGAHGDYEAALRQVRLPVLAVDVESDDLAPPRAVAHLCGKMPAARVDRWHYARSAAGGRPLDHFRWIRHHRGLVERITTWASEVVPETAGRAARSPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJX3</accession>
    <name>A0A2G1XJX3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13995</name>
        <name evidence="3" type="ORF">CYQ11_01690</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51439">
        <property type="protein sequence ID" value="PHQ51439"/>
        <property type="gene ID" value="BLA24_13995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11780">
        <property type="protein sequence ID" value="PPT11780"/>
        <property type="gene ID" value="CYQ11_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="14183" checksum="8836133D39284AD2" modified="2018-01-31" version="1">MTAAHMNDLIGKEFPWLAASHVVTAVEDDRLTLQADTRFLEAGPPGGTISGPDQMRLADLAGYLLIKHRVGHESSIRLRTMSMSFLQAPVPGALTAQVVLLRQSKRNTEVRADVVDATAGTVCAGSLLFSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK06</accession>
    <name>A0A2G1XK06_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF47 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_12750</name>
        <name evidence="5" type="ORF">CYQ11_17105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030367109.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51566">
        <property type="protein sequence ID" value="PHQ51566"/>
        <property type="gene ID" value="BLA24_12750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14357">
        <property type="protein sequence ID" value="PPT14357"/>
        <property type="gene ID" value="CYQ11_17105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="206" mass="23225" checksum="1F3A430FC09011F4" modified="2018-01-31" version="1">MRFRLTPRETSFYDMFAASADNIVTGSKLLMELLGADTSARAEIAERMRAAEHAGDDATHAIFHQLNSSFITPFDREDIYTLAGSLDDIMDFMEEAVDLVVLYQVEELPKGVEQQIEVLARAAELTAEAMPNLRTMTNLTEYWIEVNRLENQADQIHRKLLAQLFNGKYDAIEVLKLKQIVDVLEEAADAFEHVANTVETIAVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK43</accession>
    <name>A0A2G1XK43_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <shortName evidence="2">MSH acetyltransferase</shortName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mycothiol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mshD</name>
        <name evidence="4" type="ORF">BLA24_12990</name>
        <name evidence="5" type="ORF">CYQ11_17350</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol</text>
            <dbReference type="Rhea" id="RHEA:26172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16768"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="EC" id="2.3.1.189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. MshD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51608">
        <property type="protein sequence ID" value="PHQ51608"/>
        <property type="gene ID" value="BLA24_12990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14401">
        <property type="protein sequence ID" value="PPT14401"/>
        <property type="gene ID" value="CYQ11_17350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01698">
        <property type="entry name" value="MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021524">
        <property type="entry name" value="MSH_acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="243"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="250"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="33219" checksum="140017DAFE1E0C38" modified="2018-01-31" version="1">MSDVVNDVSGQRRIEVCEELSSGQLEEVRGLIAEAAAVDGQPAVSEQGRLQLKGRREGVRHVLLRDADGGLAGYGQLEENDPVEAPAGEFVVHPDRRGYGHGRALGAALLHESGKRLRVWAHGGHPAARHLAQVLGMSLFRELRQMRRPLADLDLAEPVLPEGVTVRTFRPGEDDAAWLAVNAEAFAHHPEQGSLTQRDLDDRKAEGWFDPEGFFLAEKGGELVGFHWTKVHAAQGLGEVYVLGVRPGAQGGGLGKSLTAIGLRHLAARGLPTAMLYVDADNAAAVAVYERLGFLTHETDLMYRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKC9</accession>
    <name>A0A2G1XKC9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12465</name>
        <name evidence="2" type="ORF">BLA24_28070</name>
        <name evidence="4" type="ORF">CYQ11_17570</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48916">
        <property type="protein sequence ID" value="PHQ48916"/>
        <property type="gene ID" value="BLA24_28070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51641">
        <property type="protein sequence ID" value="PHQ51641"/>
        <property type="gene ID" value="BLA24_12465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14435">
        <property type="protein sequence ID" value="PPT14435"/>
        <property type="gene ID" value="CYQ11_17570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="107" mass="11609" checksum="898547BF519DEC53" modified="2018-01-31" version="1">MDIDIKTHQVRRGGNGTEDAAGKAVENLGKSLDSSEKVADNDHGWASAGALKRCAAAWENHMIDLAKQMNSMAENLHGAANDYDATDKQAKDAMRRLQHGLDDFAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKG2</accession>
    <name>A0A2G1XKG2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrroloquinoline quinone biosynthesis peptide chaperone PqqD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pqqD</name>
        <name evidence="3" type="ORF">BLA24_11545</name>
        <name evidence="4" type="ORF">CYQ11_02780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51717">
        <property type="protein sequence ID" value="PHQ51717"/>
        <property type="gene ID" value="BLA24_11545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11966">
        <property type="protein sequence ID" value="PPT11966"/>
        <property type="gene ID" value="CYQ11_02780"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022479">
        <property type="entry name" value="PqqD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03859">
        <property type="entry name" value="PQQ_PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="101" mass="10842" checksum="1E6DF4D5CE9800AA" modified="2018-01-31" version="1">MGADGVRWRLSGGVRLGHDPVRDVKVLLHPEGVLLLNATGAAVVALCDGHTDVSGIVKRLSRTYEPVVAQDVRSFLARLAERRLIEPARAPRARGPEQGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKP4</accession>
    <name>A0A2G1XKP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12035</name>
        <name evidence="3" type="ORF">CYQ11_03275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51805">
        <property type="protein sequence ID" value="PHQ51805"/>
        <property type="gene ID" value="BLA24_12035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12051">
        <property type="protein sequence ID" value="PPT12051"/>
        <property type="gene ID" value="CYQ11_03275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="304" mass="32728" checksum="CCB398431435FA03" modified="2018-01-31" version="1">MRGMRTLTRLTGWATLLVGYATVLLGLVPLRELPPKRQQLLLLGATAVGALCWILASLLVRARRRATLRRKAWRRRYEPWPEPRRSRALAWVLGFGVALTSAAALCQGVGHDGAEGAWLAEVSRAGAGNFDVRVEKIVGEPRSTGVEANDTDQYASTVVVTVPFTSGPQQVTVDDVLTSGMPEEGRTVLLRYVPDRPDLGVRQAPDTDIGSVAGRILVLPAIWILALAAGSVTGLALYRRETSVRYARRFEPWVHLPALAILACGAGLVLPLLLGFPATATGWCLAVASAASPWLALVWVARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL33</accession>
    <name>A0A2G1XL33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance/dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_10875</name>
        <name evidence="3" type="ORF">CYQ11_00675</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51945">
        <property type="protein sequence ID" value="PHQ51945"/>
        <property type="gene ID" value="BLA24_10875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11611">
        <property type="protein sequence ID" value="PPT11611"/>
        <property type="gene ID" value="CYQ11_00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="139" mass="15143" checksum="B65418B083B270D2" modified="2018-01-31" version="1">MSRVQLALNVADLEASVTFYSRLFGVEPAKRRPGYANFVIAEPPLKLVLIEGEPGRETRLDHLGVEVESAEEVTAATERLREAGLATFEENDTSCCYALQDKVWVHGPGREPWEVYVVKADAGRLGESSALEGGMCCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLS0</accession>
    <name>A0A2G1XLS0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_09080</name>
        <name evidence="14" type="ORF">CYQ11_27690</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52069">
        <property type="protein sequence ID" value="PHQ52069"/>
        <property type="gene ID" value="BLA24_09080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16149">
        <property type="protein sequence ID" value="PPT16149"/>
        <property type="gene ID" value="CYQ11_27690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304712" evidence="10">
        <location>
            <begin position="24"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ52069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT16149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="451" mass="47500" checksum="0E3DAFD13E28ED7F" modified="2018-01-31" version="1">MTEVLLLVLALLLTLACAVFVAAEFSLTTVERSELERAAESGELGAESALKAVRSLTFQLSGAQLGITVTGLIIGMLSEPSIAALLTGPVRALGLPSSAASQVALVLGTVLSTVVLMVVGELVPKNWAISRPLPVARRVAGPQRAFSAAFRPLIRHLNNSANRVVHRLGLEPAEELATARGPQELIALARHSAKEGALEADTAELFVRTLNLADLTAENVMTPRVQVIALDARATAEDVANATRATGLSRFPVYRDTLDTVVGTAHIKDVLAIPAEERARRPVAALVREPLFVPASLTVDRLLDRLSGRRSMAIVIDEYGGTAGVVTLEDIIEEVVGEVRDEHDPHELPDLAPAGEDALGRSLYEADGATRTDQLEHIGLRAPDGPYETLAGLVAASLGRIPVEGDTVEVTGWRVEVTDASGRRAARVRLTSPPPGTAAVPGDDPAGGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLX3</accession>
    <name>A0A2G1XLX3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">S1 family peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_09470</name>
        <name evidence="11" type="ORF">CYQ11_28080</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52139">
        <property type="protein sequence ID" value="PHQ52139"/>
        <property type="gene ID" value="BLA24_09470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16219">
        <property type="protein sequence ID" value="PPT16219"/>
        <property type="gene ID" value="CYQ11_28080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758375" evidence="7">
        <location>
            <begin position="34"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="197"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ52139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT16219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="357" mass="35645" checksum="E94FC9D03C734D75" modified="2018-01-31" version="1">MNGSRIPKRRAALAAAGTLALTAASLTLQSAQAASGPAPSALSALRAGELAQHIAADLGPATAGSYYDASAGKLVVTVVDEAAAARVRATGAVARQVKHSAAELASARETLAARATVPGTAWSVDPRTNQVVVTADRTVTGAALQRLQTVVAGLGDKARIKRTSATLRPYVAGGDAIWGSGVRCSLGFNVTKSGKPYFLTAGHCGNASSSWSASQGGSRVGTTETSSFPGHDYALVRYASGASHPSAVDLYDGGSQNISRAAEATVGEQVQRSGSTTQVHGGEVTGLDATVNYEEGTVEGLIDTTVCAEPGDSGGALFDGDAALGLTSGGSGDCSSGGETFFQPVPAALQAVGAQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLZ3</accession>
    <name>A0A2G1XLZ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08675</name>
        <name evidence="3" type="ORF">CYQ11_03930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52230">
        <property type="protein sequence ID" value="PHQ52230"/>
        <property type="gene ID" value="BLA24_08675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12163">
        <property type="protein sequence ID" value="PPT12163"/>
        <property type="gene ID" value="CYQ11_03930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="240" mass="25995" checksum="E2F0EBE872461F82" modified="2018-01-31" version="1">MAELVYRPVIGLAQGMFKALDLRFDIQGAEHIPQRGGAVLVSNHIGYLDFVFCGLAARPAKRLVRFMAKDSVFRHKVSGPLMRAMKHIPVDRSAGVDAYRHALSALRSGEIIGVFPEATISTSFTLKGFKSGAARLAQEAGVPLVPMALWGTQRLWTKGRKRDLGRNHIPVAIRVGEPLTAAADESADTLTGRVRSRVQELLEAAQRAYPVRTEGPEDSWWIPAHLGGTAPAAAEAGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM37</accession>
    <name>A0A2G1XM37_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PhzF family phenazine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08940</name>
        <name evidence="3" type="ORF">BLA24_08965</name>
        <name evidence="4" type="ORF">CYQ11_04195</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52273">
        <property type="protein sequence ID" value="PHQ52273"/>
        <property type="gene ID" value="BLA24_08940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52276">
        <property type="protein sequence ID" value="PHQ52276"/>
        <property type="gene ID" value="BLA24_08965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12205">
        <property type="protein sequence ID" value="PPT12205"/>
        <property type="gene ID" value="CYQ11_04195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="28621" checksum="C2D75005DDF42717" modified="2018-01-31" version="1">MRIRIVDAFTDRPFAGNPAGVVLFDSAFPEDDRLQQIAAEVNLSETAFAHPLPAGSQDADWALRWFTPAAEVDMCGHATLATAHVLHTTGLASGTVRFAARCGLLSATTHDDGSITMDFPTSPLTPVTIPDGVAAALGATPLSTHDTSEHIGDLVVELADEKTVRALEPDIRALARHSRRGVIATAPAEDPSRGYDYVSRCFFPNVGIDEDPVTGSAHTALAPFWSARLGEQELTGLQASARTGLVRTTLLGDRTLLTGSAVTVIDGELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMB9</accession>
    <name>A0A2G1XMB9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52392">
        <property type="protein sequence ID" value="PHQ52392"/>
        <property type="gene ID" value="BLA24_08085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="121" mass="13242" checksum="0B4D5154613807D2" modified="2018-01-31" version="1">MPYDIEPRLLRAFVAVAEEPHVTRAVTRLLTAQHALGRDVRRLRRLSTGPRRACVCRRAAAGPNPGCDEETVEGLRRVWAPHSGACRSPWSSMPVSRSVRASSGPRRRPARPVGGQTGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR6</accession>
    <name>A0A2G1XMR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06545</name>
        <name evidence="2" type="ORF">CYQ11_26695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52439">
        <property type="protein sequence ID" value="PHQ52439"/>
        <property type="gene ID" value="BLA24_06545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15971">
        <property type="protein sequence ID" value="PPT15971"/>
        <property type="gene ID" value="CYQ11_26695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="581" mass="60838" checksum="24F64A4A61105646" modified="2018-01-31" version="1">MTQTVKMRPGAHYAGVAEGVYFRTARGTFVLRGPSGLLPLVDRCVPLLEDGTTEAALTDAIGGPRAHGVVKALLSALSAKGMLLDLAAAGGPPPAQPERARFGDVLAHLETHGDAPFAGFRRLRATHADVVGPLDAACSLADGLADIGVGRITVHGHDAADWPGRTSDEHTAVAFADGPAADDIPADHRVLVAVVEDPGTEPPGRLRDALLAGHGAVAVLLTDDMALVSPYLTRPEDLTTLWAAWTRARAWFTAEGPTPARRPLSAVIAGSLASHHLMDAVGVGRTDRPEAAVVTGAQLTVERVALPGPAGAGTEPAAAPPEDEPADAVAALVSAAVLGERWSGLFSWEIVDALPQLPVANTPVRGRVPGLPATLVGFGPDQAHAGVQAMLDALRLTLPPTPDAPGDAVAAAGVDPLRRTVDGALRLLSLRPPAEGEEQPIGWDDVTDLQARRLWRALRDYEDVDFTATVRTWDALGWCAVRLTGTTTGETLAWQWGDTPGDALHMALAQALSRRQSATVLGTTGEVTCAGTVVCAYLPTRLLRALAERLHALPGTLRTSERPADPVLGRLPLHSGWMWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMZ6</accession>
    <name>A0A2G1XMZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07245</name>
        <name evidence="3" type="ORF">CYQ11_27400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52625">
        <property type="protein sequence ID" value="PHQ52625"/>
        <property type="gene ID" value="BLA24_07245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16834">
        <property type="protein sequence ID" value="PPT16834"/>
        <property type="gene ID" value="CYQ11_27400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="27485" checksum="3095A0538A548ED0" modified="2018-01-31" version="1">MMGPAHSLSGAAAWLGVGAAAAAAGHPMPWAVLVVGALISAGAALAPDLDHKSATISRAFGPISRVLCEVIDKLSHAVYKATRAKSDPRRNGGHRTLTHTALWALLIGAGASALAMTGDRWAVLGILFVHVVLAVEGLLWRAARTSSDVLVWLLGAAGAWILAGILDRPGQGADWLFSGPGQEYLWLGLPIVLGALVHDVGDALTVSGCPILWPIPIGRKRWYPLGPPKAMRFRAGSWVEVKVLMPVFMLLGGIGGLGALEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN68</accession>
    <name>A0A2G1XN68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_06025</name>
        <name evidence="5" type="ORF">CYQ11_03550</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000073">
        <property type="protein sequence ID" value="PHQ52660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52660">
        <property type="protein sequence ID" value="PHQ52660"/>
        <property type="gene ID" value="BLA24_06025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12094">
        <property type="protein sequence ID" value="PPT12094"/>
        <property type="gene ID" value="CYQ11_03550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="93"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="433"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="524" mass="56865" checksum="EABF05F53D54A53C" modified="2018-01-31" version="1">MNRPAGTHRPDAPATGEQPAGPAAPRESGPPWRRLDNRLLLVQLKWLIPPALSTAFYAMITLGRLDSAAFIRLGLLTGVFLMLMLWRLVQLLTTRYRVAGDLLEVHTGLVGRRHRSIPCDRIRGVDITADPFHRVFGLVVVKITTAQRGGGDNGDTQLEALRKDEAHELRRVLLRRAATSATTTADDDGTIARMDWAWVRYMPLTCWGVLGIAILFGMALRLLDGFGVKPEKVLHTLVHLLGTDLLWQTIVVGTVAVLAIGTLAAVAMSAEEWWGYRFERDDDGNLAVNRGLLTTRSLSIDACRMRGIEIAEPLLLRLGGGAQVAAVATGLDKADDSEVTKLKTLTPGIPRALADDIAATVAGEQPSPTTVPLTAHPRAALRRRHTRAALTVLGTCAVPAVLGLFLTPVLLHIAWISALVLLPLGAWLATDAYRALGHTVRGRHLITRYGTFKRRTVALQRDSVIGWKIVRSPTQRWAGLATVMATTAAGKEGAYPVYDVQLGEGLAFADEAVPHLLAPFLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XND4</accession>
    <name>A0A2G1XND4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05685</name>
        <name evidence="5" type="ORF">CYQ11_02150</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52757">
        <property type="protein sequence ID" value="PHQ52757"/>
        <property type="gene ID" value="BLA24_05685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11856">
        <property type="protein sequence ID" value="PPT11856"/>
        <property type="gene ID" value="CYQ11_02150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="21308" checksum="07E7F394703BA53C" modified="2018-01-31" version="1">MPAYDTAAPEASPVKILIAGGFGVGKTTLVEAVSEIDPLRTEERLTSAGVGVDDLDGIESKTATTVAMDFGRITLTDAGVVLYLFGTPGQERFWFMWDDLLYGALGAIVLVDTRRLDRSFAAVDFFENRGLPFIVGANCFDGEQPYTTEEIRAALHLRDPDTPVLLLDARSREDVRGCLLSLLDRLITQAHVTASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNE0</accession>
    <name>A0A2G1XNE0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_05730</name>
        <name evidence="6" type="ORF">CYQ11_02205</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52765">
        <property type="protein sequence ID" value="PHQ52765"/>
        <property type="gene ID" value="BLA24_05730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11866">
        <property type="protein sequence ID" value="PPT11866"/>
        <property type="gene ID" value="CYQ11_02205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="28944" checksum="F7B184BA081631ED" modified="2018-01-31" version="1">MESCEPRPDGSLAPRWTGPAAALPQACHPGPVVAVTALATALAVAAGQSGQRCAWASGAVLAGQLSVGWCNDAFDARRDTGAGRRGKPVAAGRVSVPVVWGAAITALLLCVPLSLAYGPLAGAVHLTGVAAGWTYNLRLKATTFSWLPYAVGFASLPAFVALGLPGRPWPAWWALVAGALLGVGAHLADALPDIPRDLEAGVRGLPQRLGPRLTRLTLPLPLLAATAVLALGPGGAPDAAGLTALALAAATALTGAGLGRRREGAPFAAAVLVAAVDVALLLVRGSTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNK8</accession>
    <name>A0A2G1XNK8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05555</name>
        <name evidence="3" type="ORF">CYQ11_02015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52818">
        <property type="protein sequence ID" value="PHQ52818"/>
        <property type="gene ID" value="BLA24_05555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11833">
        <property type="protein sequence ID" value="PPT11833"/>
        <property type="gene ID" value="CYQ11_02015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="379" mass="38317" checksum="56C8CBE41513CD2A" modified="2018-01-31" version="1">MPVYLMSLAMVLVVREQGGSYARAGLVAALYTAGMAVGGPLVARYADRRGRRAVLVATGVVYPSALAVLVWATVPGDWAQPVVAVVAGVALPPANACMRSLWARLPLKDSEREIAYLWEALLTEVLVIGAPLMLAALMLPASAGLALTTVATIGGVGALGLALTPLPAGTERADPRREAAPGLLGPLREPAMLALTAVMAVCAVPIGLMTLAIPAFVDAHGSPGSTGVVYACWGVGSAVGALWLGRSQSEVAVHRRFPRLVLAYAVGTALPLLAVSELTLGMALAVGSAPIALVSASEMKLVSTVADGRLLTEAFTWASLATVVGDAVGQQAGGLLMEPVGPHGVFSVASGVALAGAALAFACRGLLGRRVAVPAECAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNN4</accession>
    <name>A0A2G1XNN4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52852">
        <property type="protein sequence ID" value="PHQ52852"/>
        <property type="gene ID" value="BLA24_04570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="127"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="601" mass="64398" checksum="65C4042E3D48C5A0" modified="2018-01-31" version="1">MTDLELHNAMLWRGGCFWQVPAIGNLLLIVRSRKTGRHNVSRRRAALAAGMAVLGLLVTAGCGGAGGAGGGQDAEAKRGGTLHVLSSIDLEHLDPARNNVTSSQDVSRLIYRTLTTVAAAPGRDGGKIVPDLATDTGRPSDGAKTWTFTLKEGVAFEDGRAVTSADVKYGVERSFAAELPEGVPYARMWLRGESDYKGPYKDDRGLSSIETPDARTIVFRLSRPVADFGAAVSTPLFSPVPKDKDKGVGYDGRPFSSGPYRIERFEPKKRLALTRNTHWDRATDTVRKAMPDRIVMDLNMDPAVVDQRLIAAQGEDADAVGFEPIGSASVGRVLSDPRVKSRLVKGESANTRFLSVNTRRKPLDDVRVRQAIAYALDKDALRTTRGGPVAGDLATTLLPPTLTAHVADDPYPSPGGKGDPARARKLLADAGLADGVDLTLDTSATASGKAQGEAVQESLGKAGIRVRINEISQSAYWSTVANTDQQHDLAIDGWTPDWPGASTYLPTILDGRLITRQGNNNHSQYDSPDVNARFDAIAAMPDQAQADAAYGELSRQIMRDAPVVPFLWDKSAVLTGPNVTGAYGHIAYVGRLDLVSLGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNP0</accession>
    <name>A0A2G1XNP0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_05695</name>
        <name evidence="10" type="ORF">CYQ11_02170</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52759">
        <property type="protein sequence ID" value="PHQ52759"/>
        <property type="gene ID" value="BLA24_05695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11860">
        <property type="protein sequence ID" value="PPT11860"/>
        <property type="gene ID" value="CYQ11_02170"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ52759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="31018" checksum="B1D5CF7764A659A4" modified="2018-01-31" version="1">MDSHTASPGGAAGLLLEDFSLEMTGKDGPALEEAGHLLPAGTRVNVTFLGNEEMSTRLTAARAVKALGFEPVPHLSARRMPSRAAFEEFLCRLRADGTSGQVFAVGGDPAVPEGPYEDSLALIRSGLLERYGVQQVGLCGYPEGHPAITGPRLWSALEQKAAALSERGMSGHVVTQFGFDPDPVLRWIEEARDRGVHLPVRVGVPGPAGVRRLLGYAARFGVGTSAGIARKYGLSLTHLMGTAGPDRFLRALSEGYDPQRHGTVKLHFYTFGGLRATAEWAAGFREASPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNV0</accession>
    <name>A0A2G1XNV0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04820</name>
        <name evidence="4" type="ORF">CYQ11_28710</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52890">
        <property type="protein sequence ID" value="PHQ52890"/>
        <property type="gene ID" value="BLA24_04820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11451">
        <property type="protein sequence ID" value="PPT11451"/>
        <property type="gene ID" value="CYQ11_28710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MEDS" evidence="2">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="195"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="33864" checksum="AB3E9FE37511E686" modified="2018-01-31" version="1">MNDVTAEAELFVHPALFYRNQSEYLAVNVPFIRAGLDAGEPVAVAVPRENLELLRGELGEDGAPVRFIDMQQAGRNPGRIIPRVLRAFADAHPGAHVRIIGEPVWFGRSAEEYPACVQHEALINHAFTGRRVTIVCPYDTARLAPQVLVDARATHPVVVADGEHLPSGSYAPDHVIASYNQPLSRPSGVPVFSFSFDAALLPDARHFVIEHAVALGLGDGRRDDLTLAVAELTTNSVVHGGGTGVIRIWAEDEHLVWQVEDGGHIGDPLAGRCPPPPDRPGGRGLLLVHYVSDLVRTHTRPGGTTTRCYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP28</accession>
    <name>A0A2G1XP28_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_04290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000065">
        <property type="protein sequence ID" value="PHQ53005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53005">
        <property type="protein sequence ID" value="PHQ53005"/>
        <property type="gene ID" value="BLA24_04290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="62"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="249" mass="26891" checksum="0D5F7D5F03FB3B0A" modified="2018-01-31" version="1">MARAAGPWPPGPRRVRPRRRRPRRGHGWPAPASAPTPGPPLLLPGLPPGLPAQIENGPRRGRAVALTFHGRGDPKSATAVLAEAERAGARVTVLAVGDWLDAEPQMARRVLDGGHELGNHTMRHLAVCSMPEKAAYAEIAECAERLRRLTGGVGRWFRPSRARRATDQVVRLARKAGYPHVLSYDVDSLDFTDPGAEVVRRTVLNAVRPGSVVSLHFGHAGTVAAMPAILDGLHRRGLRAVTTTELLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP80</accession>
    <name>A0A2G1XP80_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bifunctional metallophosphatase/5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_03980</name>
        <name evidence="11" type="ORF">CYQ11_07335</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19621"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:66949"/>
            <dbReference type="ChEBI" id="CHEBI:66954"/>
            <dbReference type="EC" id="3.1.4.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10144"/>
            <dbReference type="ChEBI" id="CHEBI:13197"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.1.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000060">
        <property type="protein sequence ID" value="PHQ53048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53048">
        <property type="protein sequence ID" value="PHQ53048"/>
        <property type="gene ID" value="BLA24_03980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12722">
        <property type="protein sequence ID" value="PPT12722"/>
        <property type="gene ID" value="CYQ11_07335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07410">
        <property type="entry name" value="MPP_CpdB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041827">
        <property type="entry name" value="CpdB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034089258" evidence="7">
        <location>
            <begin position="33"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="49"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="9">
        <location>
            <begin position="376"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="602" mass="64747" checksum="F6211FD9806698D0" modified="2018-01-31" version="1">MPLNRRNFLGRTAVTGAGVALAGAAGAVPAEARTADQERGRGKKRYSLTVMGTTDLHGNVFNWDYFTDAEFDDKAHNDVGLAKISTLVGQVRAEKGRRNTLLIDAGDTIQGTQLSYYYARVDPITGPGGPVHPMAQAMNAIGYDAAALGNHEFNYGIPTLRKFEEQCDFPLLGANALDAKTMRPAFRPYVMKRVCTPHGRDVRVAVLGLTNPGIAIWDKANVQGKMVFPGLEEQAAKWVPKLRSMGADVVIVAAHSGSSGTSSYGDQLPYVENAAALVAEQVPGIDAILVGHAHTEIPEYRVANKETGKQVVLSEPLKWGQRLTLFDFDLVWERGGWQVESVSAKVLNSNTVAEDARITGLLRDEHRKVVAYVNQVIGSSSAAMSAAEAPYKDTPIIDFINHVQAETVRGALAGSAYASLPVLSQASCFSRTAAVPAGKVTIREVAGLYPFENTLEARLMTGAQLREYLEFSVRYYAQTAVGAPVDPSKLTNAEGVPDYNYDVVSGLSYEVDIARAPGSRIVGLSFAGKPLDDSAEFVLAVNNYRASGGGGFPHVARAKQLWANSEEIRNTIIGWVKAKGSIDVGAFASVDWKLTRDGVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPE3</accession>
    <name>A0A2G1XPE3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_04160</name>
        <name evidence="9" type="ORF">CYQ11_14100</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53019">
        <property type="protein sequence ID" value="PHQ53019"/>
        <property type="gene ID" value="BLA24_04160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13873">
        <property type="protein sequence ID" value="PPT13873"/>
        <property type="gene ID" value="CYQ11_14100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014298">
        <property type="entry name" value="RNA_pol_sigma-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02952">
        <property type="entry name" value="Sig70_famx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="108"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT13873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="28977" checksum="423B334C84C10AAB" modified="2018-01-31" version="1">MYPHVGVDASGLATLRAAVLDRLRGFVPTAYAVPALAMLAPAAVGGPAGPCYALAESSATVGRRARRGAGAGAAATTTRRPSADSDSARMLDLVERAQAGESEAFGRLYDQYADTVYRYIYYRVGGRATAEDLTSETFLRALRRIGTFTWQGRDFGAWLVTIARNLVADHFKSSRFRLEVTTGEMLDANEVERSPEDSVLESLSNAALLEAVRKLNPQQQECVTLRFLQGLSVAETARVMGKNEGAIKTLQYRAVRTLARLLPDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPI9</accession>
    <name>A0A2G1XPI9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000038">
        <property type="protein sequence ID" value="PHQ53133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53133">
        <property type="protein sequence ID" value="PHQ53133"/>
        <property type="gene ID" value="BLA24_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="66" mass="7288" checksum="1C58658F2AD75B3D" modified="2018-01-31" version="1">MAAALDRPSERGGRGRRLTFTSPGADGYGLRSLPESCLLRGEKYAAEPDTWRRLSHAFDRLPDPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPJ9</accession>
    <name>A0A2G1XPJ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02150</name>
        <name evidence="6" type="ORF">CYQ11_04515</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030365423.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53168">
        <property type="protein sequence ID" value="PHQ53168"/>
        <property type="gene ID" value="BLA24_02150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12259">
        <property type="protein sequence ID" value="PPT12259"/>
        <property type="gene ID" value="CYQ11_04515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="147" mass="16086" checksum="93B11E6EBB4EFA1D" modified="2018-01-31" version="1">MEELDREIVELLVKDGRMSYTDLGKATGLSTSAVHQRVRRLEQRGVIRGYAAVVDPEAVGLPLTAFISVKPFDPSAPDDIADRLAEIPEIEACHSVAGDENYILKVRVATPLELEHLLARIRSLAGVSTRTTIVLSTPYEARPPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPL5</accession>
    <name>A0A2G1XPL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_02105</name>
        <name evidence="2" type="ORF">CYQ11_04470</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53160">
        <property type="protein sequence ID" value="PHQ53160"/>
        <property type="gene ID" value="BLA24_02105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12250">
        <property type="protein sequence ID" value="PPT12250"/>
        <property type="gene ID" value="CYQ11_04470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="6599" checksum="2F0529A418EA36C1" modified="2018-01-31" version="1">MILSISGVVLLGVVVFLFFRKDGLKPSHGLVCALFGFYLSSTAVAPSIRAGGASLASLLGGIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPP3</accession>
    <name>A0A2G1XPP3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02450</name>
        <name evidence="3" type="ORF">CYQ11_04815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53215">
        <property type="protein sequence ID" value="PHQ53215"/>
        <property type="gene ID" value="BLA24_02450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12306">
        <property type="protein sequence ID" value="PPT12306"/>
        <property type="gene ID" value="CYQ11_04815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="246" mass="27594" checksum="FE2C9A4B75789FFE" modified="2018-01-31" version="1">MTGRGWHGAWGLTRLCGATATFPARTPLCAGGSVIDSSFKPERDVVHYNDWAPTYEDSKVQRIRNDIHQSLVDWAASSGIQPKRILDVGCGTGALLRRVGPAFPDAELNGVDISPNMVKEASRKVPKGLRVHFLQGPAEKLPFEDGGFDLVVTTICFHHWRSRVEGIAEVHRVLAPGGRFYIADHFAIGWLRALFIAFRCRDRCHTPRELNRMLRDAGFSVQGWKRLYKLWGWLPLIQGVVAEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPV4</accession>
    <name>A0A2G1XPV4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aroC</name>
        <name evidence="10" type="ORF">BLA24_02785</name>
        <name evidence="11" type="ORF">CYQ11_05080</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53256">
        <property type="protein sequence ID" value="PHQ53256"/>
        <property type="gene ID" value="BLA24_02785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12349">
        <property type="protein sequence ID" value="PPT12349"/>
        <property type="gene ID" value="CYQ11_05080"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="394" mass="41499" checksum="923D341D668124D2" modified="2018-01-31" version="1">MSRLRWLTAGESHGPALVATLEGLPAGVPITTDMVADHLARRRLGYGRGARMKFERDEVTFLGGVRHGLTMGSPVAVMVGNTEWPKWEKVMSADPVDPAELADLARNAPLTRPRPGHADLAGMQKYGVADARPILERASARETAARVALGAVARSFLKEAAGIEIVSHVVELAAAKAPYGVHPRPSDVEKLDADPVRCLDEAASKAMVAEIDQAHKDGDTLGGVVEVLAYGVPVGLGSHVHWDRRLDARLAAALMGIQAIKGVEVGDGFELARVPGSKAHDEIVPTEDGIRRASGRSGGTEGGLTTGELLRVRAAMKPIATVPRALATVDVTTGEPTQAHHQRSDVCAVPAAGIVAEAMVALVLADAVVEKFGGDSVTETRRNVQGYLDNLAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQB2</accession>
    <name>A0A2G1XQB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">EamA/RhaT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01355</name>
        <name evidence="3" type="ORF">BLA24_29930</name>
        <name evidence="5" type="ORF">CYQ11_05540</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000020">
        <property type="protein sequence ID" value="PHQ53400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48569">
        <property type="protein sequence ID" value="PHQ48569"/>
        <property type="gene ID" value="BLA24_29930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53400">
        <property type="protein sequence ID" value="PHQ53400"/>
        <property type="gene ID" value="BLA24_01355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12429">
        <property type="protein sequence ID" value="PPT12429"/>
        <property type="gene ID" value="CYQ11_05540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="181"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="31720" checksum="8A0B69E843E61349" modified="2018-01-31" version="1">MRLKDSATERSAIAVSTAATAPASPSGHGRAGSGGSLLAALGVAAFSLTFPATAWALEGFGAWSVTTCRLVLAGLLAGVCLLAGRVPRPVRGQWGPLLVVAGGTVIGFPLLTTLALRTSTTSHAAVVVGLLPLTTAAYAAVRTGARHSRTFWVAALAGAVVVVGFALWQSGGAPNAGDGCLFAALLVCAAGYSEGGRLAREMPGWQVVGWALVLCLPVAAAGAAVALTAEPVHLTGHAVAGVLWLAVGSQFLGMWVWYRGMAAVGVARASQMQLAQPLLTLFWSVVLLGEALSPAAPVAAVAVLVCIGVTQRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQC7</accession>
    <name>A0A2G1XQC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00480</name>
        <name evidence="3" type="ORF">CYQ11_07490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53445">
        <property type="protein sequence ID" value="PHQ53445"/>
        <property type="gene ID" value="BLA24_00480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12750">
        <property type="protein sequence ID" value="PPT12750"/>
        <property type="gene ID" value="CYQ11_07490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="381" mass="40965" checksum="C7B21E202592D5AB" modified="2018-01-31" version="1">MTEFASRAREALAARGLSMRGAARALCYDPAYLSRVLNGKQCPSPQLAGALDALVGAEGALAGLLPPGAALRVDTAPENTDSDLGHLRATVAYLLDHDNRYGGDAIAPAAVRVWKTAQRKLDTGSVPDRLKCEYLTAVAELAQVAGWLLFDAGQQDAARSAFLEARILAGHAGDRSREWFVLDLLAMQGVEHGRTGESLRIADELLSQLRLPPRVALMARVRKARALADAGHRQGALNELKAARAALEDSISPCDPSWTWWINELEIAGHEGEALRALGDDGAAVPQLQRAHDLSVEFRPSGRGVLYYKISLLSAYTAIEDWPACEAMLHSLPAVLDVVSSGRNHRRLRGALQGVTRAPHAPHWLTDLARDVASTPQLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQQ6</accession>
    <name>A0A2G1XQQ6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_00905</name>
        <name evidence="5" type="ORF">CYQ11_07915</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53521">
        <property type="protein sequence ID" value="PHQ53521"/>
        <property type="gene ID" value="BLA24_00905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12826">
        <property type="protein sequence ID" value="PPT12826"/>
        <property type="gene ID" value="CYQ11_07915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="449" mass="49590" checksum="287D652EA0FBB8E8" modified="2018-01-31" version="1">MTVNAEIHAGGNTWRSLPAAQQPEWPDQEALRDVIAELESYPPLVFAGECDQLRQRLGAVARGEAFLLQGGDCAEAFDAVGADQIRNKLKTLLQMGAVLTYAGSVPVVKVGRIAGQYSKPRSKPTETRDGVTLPTYRGDSVNGFAFTPEARTPDPQRLKRMYQASASTLNLVRAFTTGGYADLRQVHAWNQDFVKSSPSGQRYEQLAREIDRAMNFMNACGVDPEEFKTVEFYASHEALVLDYESALTRVDSRTGQLYDVSGHMVWIGERTRQLDGAHIEFASKIRNPIGVKLGPTTTADEALTLIERLDPDREPGRLTFITRMGAGKIREKLPALVEKVTASGAQVVWVCDPMHGNTFEAASGHKTRRFDDVLDEVKGFFEVHKGLGTHPGGIHVELTGDDVTECVGGGDEIFVDDLHQRYETACDPRLNRSQSLDLAFLVAEMYRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XR11</accession>
    <name>A0A2G1XR11_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reductase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000001">
        <property type="protein sequence ID" value="PHQ53599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53599">
        <property type="protein sequence ID" value="PHQ53599"/>
        <property type="gene ID" value="BLA24_00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reductase_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="53" mass="5632" checksum="198631CE9EB4D520" modified="2018-01-31" version="1">MAFWLSEGRLLAGMNVNVWDVTGPIQRLIRAGARVDPEALADPGVPLDTLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9A0</accession>
    <name>A0A2G1X9A0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">recA</name>
        <name evidence="13" type="ORF">BLA24_30260</name>
        <name evidence="14" type="ORF">CYQ11_23355</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47798">
        <property type="protein sequence ID" value="PHQ47798"/>
        <property type="gene ID" value="BLA24_30260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15423">
        <property type="protein sequence ID" value="PPT15423"/>
        <property type="gene ID" value="CYQ11_23355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="11">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="12">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ47798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT15423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="373" mass="39294" checksum="FF1C02A3539A1FC5" modified="2018-01-31" version="1">MAGTDREKALDAALAQIERQFGKGAVMRLGDRPNEPIEVIPTGSTALDVALGVGGLPRGRVVEVYGPESSGKTTLTLHAVANAQKAGGTVAFVDAEHALDPEYARALGVDTDNLILSQPDTGEQALEIVDMLVRSGALDLIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKITSALNQSKTTAIFINQLREKIGVMFGSPETTTGGRALKFYASVRLDIRRIETLKDGTEAVGNRTRVKVVKNKVSPPFKQAEFDILYGQGISREGGLIDMGVEHGFIRKAGAWYTYEGDQLGQGKENARNFLKDNPDLANEIEKKIKEKLGVGVKPEEAAGETGADAAGAAAGEPAKSVPAPAKSAGKAAKAAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9B5</accession>
    <name>A0A2G1X9B5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hflX</name>
        <name evidence="8" type="ORF">BLA24_30370</name>
        <name evidence="9" type="ORF">CYQ11_23465</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47820">
        <property type="protein sequence ID" value="PHQ47820"/>
        <property type="gene ID" value="BLA24_30370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15445">
        <property type="protein sequence ID" value="PPT15445"/>
        <property type="gene ID" value="CYQ11_23465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="275"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ47820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="496" mass="54125" checksum="FB5E54716301E03B" modified="2018-01-31" version="1">MTSSSSLPQDRQSLPESLRADALMEEDVAWSHEIDGERDGDQYDRSERAALRRVAGLSTELEDVTEVEYRQLRLERVVLVGVWTSGTVQDAENSLAELAALAETAGALVLDGVVQRRDKPDPATYIGSGKAQELRDIVLESGADTVVCDGELSPGQLIHLEDVVKVKVVDRTALILDIFAQHAKSREGKAQVSLAQMQYMLPRLRGWGQSLSRQMGGGGSGSSGGGMATRGPGETKIETDRRRIREKMAKMRREIAEMKTGRDIKRQERRRNKVPSVAIAGYTNAGKSSLLNRLTGAGVLVENSLFATLDPTVRRAETPSGRLYTLADTVGFVRHLPHHLVEAFRSTMEEVGDSDLILHVVDGSHPAPEEQLAAVREVIRDVGALDVPEIVVINKADAADPLVLQRLLRIEKHSIAVSARTGQGIEELLALIDTELPRPAVEIEALVPYTHGALIARAHADGEVISEEHTPEGTLLKARVHEELAAELQQYVPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9D1</accession>
    <name>A0A2G1X9D1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_30410</name>
        <name evidence="15" type="ORF">CYQ11_23505</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47828">
        <property type="protein sequence ID" value="PHQ47828"/>
        <property type="gene ID" value="BLA24_30410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15453">
        <property type="protein sequence ID" value="PPT15453"/>
        <property type="gene ID" value="CYQ11_23505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="158"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ47828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT15453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="956" mass="103944" checksum="0A08CF837E72357C" modified="2018-01-31" version="1">MTETTSGSARGSRSKGNKSGKGLRIERIHTTPGVHPYDEVVWERRDVVMTNWRDGSINFEQRGVEFPDFWSVNAVNIVTSKYFRGATGSPERESSLRQLIDRVVLTYRKAGEEHGYFASPADAEIFEHELTYALLHQVFSFNSPVWFNVGTKQPQQVSACFILSVDDSMESILDWYKEEGMIFKGGSGAGLNLSRIRSSKELLSSGGNASGPVSFMRGADASAGTIKSGGATRRAAKMVVLDVDHPDVEAFIETKVKEEEKVRALRDAGFDMDLGGEDITSVQYQNANNSVRVNDEFMKAVETGSKFGLRARMTGEVIEEIDAKGLFRKMAEAAWACADPGIQYDDTINHWHTSPESGRITASNPCSEYMHLDNSSCNLASLNLMKFLRDDDKGNQSFDAERFAKVVELVITAMDISICFADFPTEKIGETTRAFRQLGIGYANLGALLMATGHAYDSDGGRALAGAITSLMTGTSYKRSAELAAVVGPYDGYARNADAHKRVMKQHSDANTAAKRMDDLDTPVWAAATEAWQDVLRLGEKDGFRNAQASVLAPTGTIGLMMDCDTTGVEPDLALVKFKKLVGGGSMQIVNNTVPKALKRLGYQPEQVEAVVAHIAEHGNVIDAPGLKAEHYEVFDCAMGERAISAMGHVRMMAAAQPFLSGAISKTVNLPESATVEEVEEVYFEGWKLGLKALAIYRDNCKVGQPLSAKKKEETKAVAEAPAAAEKVVEYRPVRKRLPKGRPGITTSFTVGGAEGYMTANSYPDDGLGEVFLKMSKQGSTLAGMMDAFSIAVSVGLQYGVPLETYVSKFTNMRFEPAGMTDDPDVRMAQSIVDYIFRRLALDFLPFETRSALGIHSAEERQRHLDTGSYEAADDEMDVEGLAQSAPRHVEPAKPEVPAQPAAAPAPKQVHNSTELVEMQLGLNADAPLCFSCGTKMRRAGSCYLCEGCGSTSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9L9</accession>
    <name>A0A2G1X9L9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3696 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30965</name>
        <name evidence="5" type="ORF">CYQ11_24065</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47923">
        <property type="protein sequence ID" value="PHQ47923"/>
        <property type="gene ID" value="BLA24_30965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15548">
        <property type="protein sequence ID" value="PPT15548"/>
        <property type="gene ID" value="CYQ11_24065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022532">
        <property type="entry name" value="DUF3696"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014592">
        <property type="entry name" value="P-loop_UCP034888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12476">
        <property type="entry name" value="DUF3696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034888">
        <property type="entry name" value="P-loop_UCP034888"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="3">
        <location>
            <begin position="250"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3696" evidence="1">
        <location>
            <begin position="344"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="393" mass="41810" checksum="E4604041ECA413A1" modified="2018-01-31" version="1">MIDRLTLTNFKAFRHADLPLAPLTLLTGLNSSGKSSVLQALALLQQSYTAGDLDQVRALAEDSGGLGDVAAVDNGFLLNGELVGLGTGHDVLHEDFTGDEPEITLAVSEGAYRYAWTVAYEAEQNLLPLTRVALPLTTEGAKPPAGDAAVIPGFFTAGFQYLHADRISPAESYPRDHHAAIGRGFLGVRGEHTVNFLRHHARDEVIDGPLRHPRAQSPRLLDQAAAWIGELCPGVDIQAAAIEGTDSVRLSYGFDGPLGTRRRPTNVGFGLTYVLPIVVACLTAGPGSLVLLENPEAHLHPRGQSRMAALAAAAAAQGAQLVVETHSDHVLNGVRLAVKRGVLAPDQAALHYFRGNGAGVDITSPCIDRDGLLDQWPEGFFDELENTLDELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9N5</accession>
    <name>A0A2G1X9N5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative NAD(P)H nitroreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_31040</name>
        <name evidence="7" type="ORF">CYQ11_24140</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47938">
        <property type="protein sequence ID" value="PHQ47938"/>
        <property type="gene ID" value="BLA24_31040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15563">
        <property type="protein sequence ID" value="PPT15563"/>
        <property type="gene ID" value="CYQ11_24140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000232">
        <property type="entry name" value="YdjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ47938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="187" mass="20379" checksum="F804F9D89B7E84C7" modified="2018-01-31" version="1">MRLEEAITSRRSVGRLTAPAPSDAELHDIVALAMTAPDHGRLSPWRVIPLRGASRETLGERFAEAALDGEPAARERAARKPLRAPLLLTLVFSPVPDHAKVPEWEQLAAAVCAVHTMTLLLHARGWGSIWRTGAVVTDPGVHALLGLRKHEQLLGWLYVGTPDARHAPVPRPAGRPEDKLRPFAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Q5</accession>
    <name>A0A2G1X9Q5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Biotin transporter BioY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31260</name>
        <name evidence="2" type="ORF">CYQ11_24300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47945">
        <property type="protein sequence ID" value="PHQ47945"/>
        <property type="gene ID" value="BLA24_31260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15569">
        <property type="protein sequence ID" value="PPT15569"/>
        <property type="gene ID" value="CYQ11_24300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="382" mass="39720" checksum="322ED99275AEF030" modified="2018-01-31" version="1">MDAARQPQRPAVTELRLSAFKSHRNAVYPLAPLTLFRGASGSGKSSALEAYGALARLAGGDRLDEALAPVAGGALACVPQSARPDAQGRRGFRIGCTVEGPVGPVRLDVAVQAEPELRVVGERLSASGRVLLSTALRDPGLRKVEAAWHTAGSVPVTRAPLPDDRLGTALLPLRVAGKTAGQRMVLDAAEQTVVALRSVFPCDPRPELMRTPVAARDGLLRGACDNVAAVLGRTRNECVTRHAALVAAAGAGCRGQVEGLGVEGLTGGLVRAVLARGPGADTPLERLGDGELRYLALCLVLLTGPGVLEVDPAAEVLPARQVLTVLADGFDRCLDGRQARELLGLAARMCERGHIRLVGSVRGVVAEVAEEVMGASMVDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAH6</accession>
    <name>A0A2G1XAH6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Teichoic acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_33040</name>
        <name evidence="7" type="ORF">CYQ11_26090</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48244">
        <property type="protein sequence ID" value="PHQ48244"/>
        <property type="gene ID" value="BLA24_33040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15871">
        <property type="protein sequence ID" value="PPT15871"/>
        <property type="gene ID" value="CYQ11_26090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="28637" checksum="8002662673DE811A" modified="2018-01-31" version="1">MADQNSASKASERVPTVIADDVHIVYRVYGGNTGRGSATAALNRIIKRKPGAGVREVHAVKGVSFTAYRGQAIGLIGSNGSGKSTLLKAVAGLLPTERGKIYTDGQPSLLGVNAAMMNDLTGEKNVMLGGLAMGMSREQIKERYQGIVDFSGINEKGDFITLPMRTYSSGMAARLRFSIAAAKDHDVLMIDEALATGDRSFQKRSEERIRELRKEAGTVFLVSHNNRSIRDTCDRVLWLERGELLMDGPTDEVVRAYEKETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAI7</accession>
    <name>A0A2G1XAI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_32935</name>
        <name evidence="10" type="ORF">CYQ11_25985</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48225">
        <property type="protein sequence ID" value="PHQ48225"/>
        <property type="gene ID" value="BLA24_32935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15852">
        <property type="protein sequence ID" value="PPT15852"/>
        <property type="gene ID" value="CYQ11_25985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="41750" checksum="5D6EF734A47CDF3A" modified="2018-01-31" version="1">MKRQLFSSDHEAFRETVRAFLAKEVTPHYEQWERDGVVSRDAWLAAGRQGLLGLAVPEEYGGGGESDFRYSVVLAEEFARAGAAGLAIGLHNDVIGPYLTSLATAEQKQRWLPGFCTGETITAIAMTEPGAGSDLQGIRTTAEDRGDHWLLNGSKTFISNGILADLVIVVAKTTPEGGARGLSLFVVERGTAGFERGRNLDKIGQRAQDTAELFFHDVRVPKENLLGELNGAFGHLMTNLPQERLNIAVAAVAAAEHLLEITTGYVKEREAFGRPLARLQHIRFEIAEMATECAVTRAFLDRCVGDHDRGELDAVHASMAKWWATELQKRVADRCLQLHGGYGYMTEYRVARAFTDGRIQTIYGGTTEIMKEIIGRSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAJ2</accession>
    <name>A0A2G1XAJ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_33035</name>
        <name evidence="12" type="ORF">CYQ11_26085</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48243">
        <property type="protein sequence ID" value="PHQ48243"/>
        <property type="gene ID" value="BLA24_33035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15870">
        <property type="protein sequence ID" value="PPT15870"/>
        <property type="gene ID" value="CYQ11_26085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="62"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="311" mass="34089" checksum="7FD015C7D2B7CDE1" modified="2018-01-31" version="1">MSETTHDSAVAMSAPPSPDDGLSAAELAKKYGLAVSGARPSLPDYARQLWDRRHFIIAFSRAKMTAQYSQAKLGQVWQVATPLLNASVYFLIFGVLMQQGKDMGIGTYIPFLVTGVFVFTFTQSSAMAGVRSIAGNLGLVRALHFPRAALPISFAMQQLQQLLLSMCVLFVFLVGFGHMPALSWLLIVPVLVCQFVFNTGLAMILARMGSKTPDLAQLLPFLTRTWMYASGVMYNLTAALEKTKAPAWVVDVLGANPAAVYIDLMRWSLIDNHSRIHLPPHVWALAVGWALVVGVGGFVYFWKAEEQYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAV7</accession>
    <name>A0A2G1XAV7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_31425</name>
        <name evidence="7" type="ORF">CYQ11_24465</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48341">
        <property type="protein sequence ID" value="PHQ48341"/>
        <property type="gene ID" value="BLA24_31425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16766">
        <property type="protein sequence ID" value="PPT16766"/>
        <property type="gene ID" value="CYQ11_24465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="49"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="257" mass="28356" checksum="E540576A83E50E8F" modified="2018-01-31" version="1">MVSLPLLWAVMSAFKTDNEIFTSPWALPKGLHFDAWGRAWSDAHMSQYFVNSLVVVAGSLAGTMLLGSMAAYVLARFEFPGNRFFYFLFVGGMSFPVILALVPLFFVMKNMHLLNTYPGLILVYIAYSLPFTVFFLTGFFRTLPSSVAEAALIDGASHTRTFFQVMLPMAKPGLISVGIFNFLGQWNQYLLPAVLNIGDEDKKLLPQGLVALAVSQRYKGDWSGLFAGLVIAMLPVLAAYVIFQRQVQQGLTAGALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB38</accession>
    <name>A0A2G1XB38_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_29175</name>
        <name evidence="6" type="ORF">CYQ11_06300</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48448">
        <property type="protein sequence ID" value="PHQ48448"/>
        <property type="gene ID" value="BLA24_29175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12556">
        <property type="protein sequence ID" value="PPT12556"/>
        <property type="gene ID" value="CYQ11_06300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="51"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="36865" checksum="0F2633D4D479739E" modified="2018-01-31" version="1">MSARGVLSPVPSPGPPPARPGGPGCGTTVLYVHFHPAAGTAALDEETYDGLLGLLAEVTPVVEALPPDAALLDVRGATRYFGHDPVELAELLRVRTLARYAADCTVGIAANPMLARMAAQDGAPGAIRTLGAEPDAVAAFLAGKPAAALYGVGPATARTLCSYGLDSVGRIAAAPLPALQRILGAAAGRRIHERARGVDPTPVTPDARARSMGAEHRFGGDELDAAHRRRALLALADGLGARMRRSGQVARGLKLTVRYADGSSTTRTRAFPEPTAHTPELTAVAYALHASLGLQRARVRAVALRAEGLDAAEHAAHQLTFDPADEKARRVEEAVDRARARFGMGAVGPAATLDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBU3</accession>
    <name>A0A2G1XBU3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPFH/Band 7/PHB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_28865</name>
        <name evidence="5" type="ORF">CYQ11_06600</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48717">
        <property type="protein sequence ID" value="PHQ48717"/>
        <property type="gene ID" value="BLA24_28865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12602">
        <property type="protein sequence ID" value="PPT12602"/>
        <property type="gene ID" value="CYQ11_06600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="34394" checksum="C332B9824EC65FE5" modified="2018-01-31" version="1">MEPIIIVLIILVVLVFIALMKTVQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDSIRNRIDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVSSFIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDKRAAILTAEGIRQSQILTAEGEKQSAILRAEGEARAAALRAEGEAQAIRTVFESIHAGDADEKLLAYQYLQMLPKIAEGDANKLWIVPSEIGDALKGLSGAVGSLTPKSGGGAPSPAPAKQNPRREQPPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBW9</accession>
    <name>A0A2G1XBW9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF839 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28525</name>
        <name evidence="3" type="ORF">CYQ11_06945</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48733">
        <property type="protein sequence ID" value="PHQ48733"/>
        <property type="gene ID" value="BLA24_28525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16396">
        <property type="protein sequence ID" value="PPT16396"/>
        <property type="gene ID" value="CYQ11_06945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304704" evidence="1">
        <location>
            <begin position="37"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="473" mass="50646" checksum="7772BE5D257CB4CF" modified="2018-01-31" version="1">MSLSRREFAKRSAATGAGVALAGSVGVLASAPGALAAQPGAGRPPGYGPLLADPAGLLALPAGFTYRVVTRTGVTRLESGESTPSNHDGTAAFAGRRGTTLLVNNHELKGPRANWPHPVPLADGLVYDPAAAGGCTVVEVAPHGDHVAEWVGIAGTSTNCAGGTTPWGTWLTCEETEDKAGQNGMTKDHGYVFEVDPHDRRAARHPKPVKALGRYAHEAVVVDPDPARGHLYLTEDAAGPNGLFYRWVPPHGFRHGRGRLRALADDAGVLQAFTCYDSGGRFVDDLSRATHTGTVYGVDWTTVPDRDARTTSVRRQFHDGEVTRARKLEGMWWGDGGVYVVASFAREESPVRHDGQVWFYDPRRRTLTLKVLLGVNPHPERDGAFDGPDNITVSPHGGLVIAEDGEGVQHLFGALDDGRTYPIARNELNIGTPQKPEYSEFTGVTFAPDGRTLFANIQEPGIMLAITGPWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBX3</accession>
    <name>A0A2G1XBX3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28800</name>
        <name evidence="2" type="ORF">CYQ11_06665</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48705">
        <property type="protein sequence ID" value="PHQ48705"/>
        <property type="gene ID" value="BLA24_28800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12614">
        <property type="protein sequence ID" value="PPT12614"/>
        <property type="gene ID" value="CYQ11_06665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="172" mass="18795" checksum="88B8792556B25598" modified="2018-01-31" version="1">MSSEPTRRIVILRHAKAEWSDVDDHERPLAERGRKDAPVAGRWLAGSGITPDLALCSTSARTRETWKLAVSELPERPRTVYEERMYEASLGELIALLNETSDEVRDVVLIGHNPGMHALADALAGEADGDLLARMNRSGFPTSAIAVVEFGGSWKSVEHGVGKLVAYWAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC45</accession>
    <name>A0A2G1XC45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28435</name>
        <name evidence="2" type="ORF">CYQ11_07035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48729">
        <property type="protein sequence ID" value="PHQ48729"/>
        <property type="gene ID" value="BLA24_28435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16399">
        <property type="protein sequence ID" value="PPT16399"/>
        <property type="gene ID" value="CYQ11_07035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="348" mass="36175" checksum="68AEE2C37A9C958B" modified="2018-01-31" version="1">MDGIPPLVDQHSHGAVHGELGLGEFETHLAKAQGATGPAPPGTTFFDSRAGLAVRRWCPPLLGLEPHCAPVRYLARRRELGAYRAGLLLLRGAGIGTFLLEQGAPGALTSPAELARAAEGRAHEVVRLEPLAAQVADTSGGTDAFLSYTAEALYAAAGSAAAFASGAAACAGGPPCAAEVRQAAGRWLRTRGTGAAPADPVLVRHLLWSAVATGLPVQLHCPDPRRLTGFLSATAGRGTDLVLLPGPGHRRQAARLAAVFPHVYADVGARPEEALREAPFGKLLFSTGARALAELYVVAARLFVRAMEHLVRDWVADGWCRAAEAGRIASLVAAGTARRVYRLEAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC87</accession>
    <name>A0A2G1XC87_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27430</name>
        <name evidence="7" type="ORF">CYQ11_18215</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48805">
        <property type="protein sequence ID" value="PHQ48805"/>
        <property type="gene ID" value="BLA24_27430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16642">
        <property type="protein sequence ID" value="PPT16642"/>
        <property type="gene ID" value="CYQ11_18215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="20808" checksum="2CE3716AF9DEA170" modified="2018-01-31" version="1">MTHDAPARWDRKMRQRLAHGEAAALGELYDRFGSLVHGLAHRVLGDEGGADGVTREVFAHVWEHPEEFDPRHGPLRSWIAGLAHRYAVGRLRRAADDGERSPEEIEEQVRAASAAARADYIVTSMPAPLRAALDLAYFRRLDYRQAAARLGVTEDEARRRLRLGLQLLSTAHDGPRAVSPPGGCGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCB2</accession>
    <name>A0A2G1XCB2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27395</name>
        <name evidence="5" type="ORF">CYQ11_18250</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48799">
        <property type="protein sequence ID" value="PHQ48799"/>
        <property type="gene ID" value="BLA24_27395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14551">
        <property type="protein sequence ID" value="PPT14551"/>
        <property type="gene ID" value="CYQ11_18250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="226" mass="24195" checksum="64B1502EF04734A4" modified="2018-01-31" version="1">MTSSPTGTAAAAPAPGLRGRKRERTRRAISDAAFRLFAEEGFEAVTLTRIAAAAEVAPATVFTHFASKEEIFFSRREQFREGVTAAVADKATGAEVLDGLRRFYADACDLVIAAESVDNARVFARVLLESPALGRSYLPIVQERRRLLAERLAERPGCRGERAELELFAGLVMAAGEAVFGAMHRALSEGEPADVVRAAVGAALARGFDRLARAYEGSDVLDAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCJ0</accession>
    <name>A0A2G1XCJ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27860</name>
        <name evidence="2" type="ORF">CYQ11_17780</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48879">
        <property type="protein sequence ID" value="PHQ48879"/>
        <property type="gene ID" value="BLA24_27860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14474">
        <property type="protein sequence ID" value="PPT14474"/>
        <property type="gene ID" value="CYQ11_17780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="158" mass="17163" checksum="D9598B082AB29506" modified="2018-01-31" version="1">MTIVEERPAIDAGTLVSAELRKTIATDVRAKYDHITADMAHRGVGQMLAFVAASATSEKPLSPSPLVDDFWHAFVLRTKAYADFCQQTFGTFVHHQPGFLDREDHGGGKGLRARTVDAIQAAGYAVDLEFWPELDIADCSQCHANCHNSPKHAITAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCK5</accession>
    <name>A0A2G1XCK5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="6">FDTS</shortName>
            <ecNumber evidence="6">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thymidylate synthase ThyX</fullName>
            <shortName evidence="6">TS</shortName>
            <shortName evidence="6">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thyX</name>
        <name evidence="7" type="ORF">BLA24_22855</name>
        <name evidence="8" type="ORF">CYQ11_23220</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48950">
        <property type="protein sequence ID" value="PHQ48950"/>
        <property type="gene ID" value="BLA24_22855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15405">
        <property type="protein sequence ID" value="PPT15405"/>
        <property type="gene ID" value="CYQ11_23220"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="28357" checksum="EDCB4F80BEE07311" modified="2018-01-31" version="1">MTDTPTEDAQAAKPTFRSDVTVELVKHSAADSDVLWAARVSTAGEQSLEEITKDPERSKGLINYLMRDRHGSPFEHNSMTFFISAPIFVFREFMRHRVGWSYNEESGRYRELEPVFYVPGESRKLVQEGRPGKYVFVEGTEAQHELTGRVMEDSYRRAYEAYQEMLAEGVAREVARSVLPVGLFSSMYATCNARSLMHFLGLRTQHELAAVPSFPQREIEMVGEKMEAEWAKLMPLTYAAFNKNGRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCP7</accession>
    <name>A0A2G1XCP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22940</name>
        <name evidence="3" type="ORF">CYQ11_23135</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48965">
        <property type="protein sequence ID" value="PHQ48965"/>
        <property type="gene ID" value="BLA24_22940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15390">
        <property type="protein sequence ID" value="PPT15390"/>
        <property type="gene ID" value="CYQ11_23135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="482" mass="47951" checksum="55A34F7AAA627F42" modified="2018-01-31" version="1">MSVEVMMACIQGADGDELIHKGQALMDAKDEIERIGNDLKGHVTRTTWDGEGGTAFHEWGDDFAKQVLKLANFSGVAGKYMRQAGSDLKTAIKALPPIPEGTMGQCFADADKEKARVEALDKVRGQVAEQMQRIASSYRASTWEIKGAELPRLPGPPDTIMPISSDSEAYGASGGRSGGTSGGAYGGAVSTPSHGSFGGSASSGGHGTVSAGHQSVDSPSGTGSVNVPSSPGHIDRVPLPDNIGTNIDGTTTPTAPPVPSNVGTLPPPTSAGPGGTPPLVTPPMGPMTPNLGGGPRTVGGGATRMPPTAGGTGKFGTGPISGSIRPNIPRADTGIIGGMPSHGQPGAPGARGVPRGTVIGGESQPTGRGMAGGGMPGGGMRSGAGGSGYAGGTRRLVSEPGGVVGGPRGSQGARRDFTPGGAGLVRDKGTSTGNGGLVGGPPRAGQRSSDQQRDGAGVPDYLTEDEETWSTGGHNAVPPVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCW5</accession>
    <name>A0A2G1XCW5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_23650</name>
        <name evidence="12" type="ORF">CYQ11_22420</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49083">
        <property type="protein sequence ID" value="PHQ49083"/>
        <property type="gene ID" value="BLA24_23650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15271">
        <property type="protein sequence ID" value="PPT15271"/>
        <property type="gene ID" value="CYQ11_22420"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="538" mass="58335" checksum="0D1181E271FDB696" modified="2018-01-31" version="1">MSAVTDAPDAPDDSFHVFDTTLRDGAQREGINLSVADKLTIARHLDDFGVGFIEGGWPGANPRDTEFFERARKEISFRHAQLVAFGATRRAGVRAEDDGQVAALLDSQAPVVTIVAKSHDRHVELALRTTLEENLAMVRDTVRHLRAHGRRVFVDCEHFFDGYRANPAYATQVVRTAHEAGADVVVLCDTNGGMLPAQVEAVVRTVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNSNLFPVVAALEIKYDRRVLPPGKLAEMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAGLHASAIKVDPDLYQHIDPERVGNTMRMLVSDMAGRASIELKGKELGVDLGGDRALIGRVVERVKERELAGYTYEAADASFELLLRAEVEGRARRFYRVESWRAIAEDRPDGTHANEATVKLWAKGERIVATAEGNGPVNALDRALRGALERIYPQLASLELTDYKVRILEGSLGTGSITRVLVSTSDEHGEWSTVGVGENVIAASWQALDDAYAYGLRRAGVEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ6</accession>
    <name>A0A2G1XCZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_23705</name>
        <name evidence="5" type="ORF">CYQ11_22370</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49090">
        <property type="protein sequence ID" value="PHQ49090"/>
        <property type="gene ID" value="BLA24_23705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15264">
        <property type="protein sequence ID" value="PPT15264"/>
        <property type="gene ID" value="CYQ11_22370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="21464" checksum="A8D49618B9F4F504" modified="2018-01-31" version="1">MGHREDLLDGAKRCLLDKGWVRTTARDIVAASGANLASIGYHYGSKDVLMMEAFLKLTEDWGEQITGALARAAEAGVPRDERLAAVVDGIVDSFAGDRQFWAAQLEVIGQLDNHPELRRRFAAVMPEGRVGLVAVFEGVDDSAVPAGAARTTGFLYYALFTGLWVQWLIDPKQVPSGRDVVEGLRRAVAGNVLEAPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDB2</accession>
    <name>A0A2G1XDB2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_24490</name>
        <name evidence="15" type="ORF">CYQ11_21580</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49227">
        <property type="protein sequence ID" value="PHQ49227"/>
        <property type="gene ID" value="BLA24_24490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15122">
        <property type="protein sequence ID" value="PPT15122"/>
        <property type="gene ID" value="CYQ11_21580"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="36"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ49227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT15122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="362" mass="37916" checksum="7AA883EBE7290E5D" modified="2018-01-31" version="1">MSANNGRQIPGTHQWRGIIEEYRDRLPVTDTTPVVTLREGGTPLVPAQVLSERTGCEVHLKVEGANPTGSFKDRGMTMAITRAKEEGAQAVICASTGNTSASAAAYAVRAGMVCAVLVPQGKIALGKMGQALVHGARILQVDGNFDDCLTLARGLSENYPVALVNSVNPVRIEGQKTAAFEIVDALGDAPDIHVLPVGNAGNITAYWRGYREYAADGIASHTPRMWGFQASGSAPIVRGEPVKDPHTIATAIRIGNPASWQFAEQARDESGGLIDEVTDRQILAAYRLLASQEGVFVEPASAASVAGLLKAAELGLVDPGQRIVCTVTGNGLKDPDWAVAGAPQPITVPVDAGTAAERLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDH1</accession>
    <name>A0A2G1XDH1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24580</name>
        <name evidence="3" type="ORF">CYQ11_21490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49241">
        <property type="protein sequence ID" value="PHQ49241"/>
        <property type="gene ID" value="BLA24_24580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15107">
        <property type="protein sequence ID" value="PPT15107"/>
        <property type="gene ID" value="CYQ11_21490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="155" mass="16830" checksum="8244307A928ADA3C" modified="2018-01-31" version="1">MPGGAGEGGGSGVDHPFLALERELTVFLRRARSSSGEMAREVHPDLEPAAYGLLVRLVDAGQQRATDLAAYFGVGKATMSRQLRALGELGLVTRDPDPADGRASLIQLTDEGRARFTRVRDARRAQYMSKLADWDPTEVAELARLLHQLNESAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDL2</accession>
    <name>A0A2G1XDL2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_25030</name>
        <name evidence="6" type="ORF">CYQ11_21040</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49320">
        <property type="protein sequence ID" value="PHQ49320"/>
        <property type="gene ID" value="BLA24_25030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15031">
        <property type="protein sequence ID" value="PPT15031"/>
        <property type="gene ID" value="CYQ11_21040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304906" description="Endopeptidase La" evidence="2">
        <location>
            <begin position="33"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="4">
        <location>
            <begin position="250"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="362" mass="38064" checksum="79CBDFF060F46401" modified="2018-01-31" version="1">MPRRTATMLASLLTLVALLCAGVLIPVPYSEMSPGPTVNTLGEHGGEPVLQISGHKTYPTTGHLNMTTVRVTGSQYRMNLVEAVYGWLAHDNLVVPHSTLYPEDKSPDELNQETAEEFTQSQESAKVAALKQLDIPVGTRVVVSSVVKGSPAEGQLHAGDMIKAVDGTEVKEPGDVAKLVTRHKAGEKVTFLTVPAKEAAAAEKEKRQPATEETVALVTRPAPDDKRAIVGIQAGTDHTFPFTINIKLADVGGPSAGLMFALGIVDKLTPEDLTGGKFVAGTGTIDENGKVGPIGGIEMKTVGARSKGARYFLTPKDNCAAAAKDTPAGLTLVKVDTIKDALQSLEKVRKGDTAGLPSCSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDW8</accession>
    <name>A0A2G1XDW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">EamA/RhaT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_25310</name>
        <name evidence="5" type="ORF">CYQ11_20765</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49369">
        <property type="protein sequence ID" value="PHQ49369"/>
        <property type="gene ID" value="BLA24_25310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14983">
        <property type="protein sequence ID" value="PPT14983"/>
        <property type="gene ID" value="CYQ11_20765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="188"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="337" mass="34274" checksum="7DBCCBDA814F7A94" modified="2018-01-31" version="1">MRAPYAEDVSAARTRRDALPTSQAPRVPRSAPVPASAAAVRADLLLLALAVAGVSLSAPLIAATAAPALAIAFWRNAMAVGALTPFVLLRRGSRAELSGIGRRPALLAVAAGALLALHFGMWLPSLHMTSVASSTALVTTTPVWTTLLLRLSGHRPPALVWAGTALAFLGVLILTGVDLSMSPRALAGDALALAGGIAGAGYVLLGAEVRRTASTLAYSYVCYGTTAVLLLAVCLASGASLGGYDPRTWLKLALLTLTAQLLGHSLMNRVVKGLGPSVTSTAILLETPGAALIAALWLGQLPAAAAYPALAVIMAGLALVVLGDRRKEPAVVPETGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE12</accession>
    <name>A0A2G1XE12_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25955</name>
        <name evidence="2" type="ORF">CYQ11_20110</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49484">
        <property type="protein sequence ID" value="PHQ49484"/>
        <property type="gene ID" value="BLA24_25955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14865">
        <property type="protein sequence ID" value="PPT14865"/>
        <property type="gene ID" value="CYQ11_20110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="157" mass="18635" checksum="2E9072B1D51EFA46" modified="2018-01-31" version="1">MPPRSKVQNHDEAKRWLLEGKSYAWMVKTYQEKYNIKTSPGYWATYANRADLPLRLVRDTDLIPWKIAKEHRWNYNLVMLRCEARQRAGEKLNDEEASKLASWKKWLEEDKLVIYYDPETKDGFYAVPREDRDTDLIRVPDNPALLRSKSTRTKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEG4</accession>
    <name>A0A2G1XEG4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26795</name>
        <name evidence="3" type="ORF">CYQ11_18840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49627">
        <property type="protein sequence ID" value="PHQ49627"/>
        <property type="gene ID" value="BLA24_26795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14652">
        <property type="protein sequence ID" value="PPT14652"/>
        <property type="gene ID" value="CYQ11_18840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="36823" checksum="11EB1D9FF7E6C3EE" modified="2018-01-31" version="1">MVKLSVVVPFFNVQTYAPDTLRSLRANAREDFEFILVDDCSTDGTGQVLERAGRELPGAVLVRHEKNGGLATARNTGLDAARGEYVTFLDGDDWLAPGYYTELLAFAEELGVDFVRTDHVQCTGRTRTVHRAPVGRRGVALTPREAILPADRSTSVDYPYAWAGVYHRRLLDEGVLHFHDGLRTAEDRPWIWRLHREARSFAVTGLLGVFYRRGVATSLTQIGDVRQLDFLRAFDQVIDETSRDRDAEKLLPKAVRTYCAIIAHHLAHIERFEPDVARTLRSKSAAALRRMPRHLVEDALRAMDEDRAVRLRRLRRRPVRAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL5</accession>
    <name>A0A2G1XEL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate/glutamate racemase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Aspartate/glutamate racemase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26735</name>
        <name evidence="4" type="ORF">CYQ11_18900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49619">
        <property type="protein sequence ID" value="PHQ49619"/>
        <property type="gene ID" value="BLA24_26735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14661">
        <property type="protein sequence ID" value="PPT14661"/>
        <property type="gene ID" value="CYQ11_18900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="24288" checksum="BF8B84F19823A36A" modified="2018-01-31" version="1">MKTIGLIGGMSWESTAEYYRLLNELTRDRLGGLHSARCVLYSVDFADIERLQTEGRWAEAGETLAAAARSLAAAGADMVLICTNTMHKVADGVEAAVSIPLLHLADATAEAVRAAGLRRVGLLGTAFTMEQDFYRGRLEAGGLDVLVPDAEGRALVHRVIYEELCLGVVQDASRAAYRKVIEDLVADGAEGVILGCTEIELLVGPADSPVPVFPTARLHAEAAVAAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XES3</accession>
    <name>A0A2G1XES3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_23860</name>
        <name evidence="8" type="ORF">CYQ11_22210</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49705">
        <property type="protein sequence ID" value="PHQ49705"/>
        <property type="gene ID" value="BLA24_23860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16721">
        <property type="protein sequence ID" value="PPT16721"/>
        <property type="gene ID" value="CYQ11_22210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="38047" checksum="11556BA72553AFEA" modified="2018-01-31" version="1">MTIPEQQAAPEGAAPLLTVEGLVKHFPITKGLLRRQVGAVQAVDGLTFDVRAGETLGVVGESGCGKSTMGRLITRLLEPTAGKVEFEGKDITHLGVAGMRPLRRDVQMIFQDPYSSLNPRHTVGTIVGAPFRLQGITPEGGVKKEVQRLLGLVGLSPEHFNRYPHEFSGGQRQRIGIARALALKPKLVVADEPVSALDVSIQAQVVNLLDDLQQEMGLTYVIIAHDLSVIRHVSDRIAVMYLGKLVELTDRTSLYTTPMHPYTKALLSAVPVPDPRRRARPGAAPGGGGRILLKGDVPSPISPPAGCRFHTRCWKATDVCKQQEPPLLALRTGHQVACHHPENAPAPAARGAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEZ6</accession>
    <name>A0A2G1XEZ6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_19305</name>
        <name evidence="11" type="ORF">CYQ11_11495</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49800">
        <property type="protein sequence ID" value="PHQ49800"/>
        <property type="gene ID" value="BLA24_19305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13424">
        <property type="protein sequence ID" value="PPT13424"/>
        <property type="gene ID" value="CYQ11_11495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="81"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="506" mass="54534" checksum="85C3FF4CAE7D5A4F" modified="2018-01-31" version="1">MGETERTAPAPGRGWSRLGRPRGGRAAAVLAPVAVMLALGLWGLDRGTVWRDEGATLQVARRSVPEIWHLLGNVDAVHGLYYLLMHPLMALRADETTLRLPSVLAAAATAGLTAAVGVRLARPRVGLWAGLLYAVTPFVSHYAQEGRSYALVAAGAALATWLLLRAVEHPSYGWWAGYGAAVAVTALLHEFAVLLLAAHGVTLLASRVPWRVWRGWGCAAVAACAVLAPLAVVSRGQSEQVSWLRTPGYEQARALLYAFAGPGDAVLAGTLVLTAVALLVPLPRTGPLQLNAVALPLALIPPLLLYVAAQRQPLFLDRYLLFSLMGVPLLAAAGAERLLGLLPWRRVAITAGVVAVAVAFMAQLPAQERERLPASRGDQPALVASAAGKLVRPGDAVLFLPHYERRISLFYPDRFTGLSDLTLRRSAAASGTLFGEEVTAARLRERLSRLAPRRRVWVVWDTSTVGTRWFRAQRAEFAKTQVLDALYREESTVYVHGGAVSLYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB3</accession>
    <name>A0A2G1XFB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4429 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_20095</name>
        <name evidence="5" type="ORF">CYQ11_10695</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49930">
        <property type="protein sequence ID" value="PHQ49930"/>
        <property type="gene ID" value="BLA24_20095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13294">
        <property type="protein sequence ID" value="PPT13294"/>
        <property type="gene ID" value="CYQ11_10695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027860">
        <property type="entry name" value="DUF4429"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14472">
        <property type="entry name" value="DUF4429"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4429" evidence="3">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4429" evidence="3">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="305" mass="32466" checksum="B4175C0F12DA7A50" modified="2018-01-31" version="1">MAEILQTDGTWVFDGDTIRIVPGRERGVHVLRQTLGELAVPLAAVAGLAFEPARRGGRLRLRLRGGADPLSQVTRGRLPESADPYQLTVDADRTGVAEYFVDEVRNALLLEQVPAGPTDRYLLPGPAVPISVGAGDGTASFDGERIRLEWNWKTEEGKKSSGTRLLPVTQVSGVEWQPAAGLENGYLRFTVPHAPTEAPPKHDPHAVELFGFKKDALMALVAAAVVARLPHPGAAPVAEPAPPGPLAALPAGRAPAAEAAHPAASAADDHDALLRRLRELGELHHSGVLTDEEFTAAKQAILKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFE8</accession>
    <name>A0A2G1XFE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_20100</name>
        <name evidence="10" type="ORF">CYQ11_10690</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49931">
        <property type="protein sequence ID" value="PHQ49931"/>
        <property type="gene ID" value="BLA24_20100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13293">
        <property type="protein sequence ID" value="PPT13293"/>
        <property type="gene ID" value="CYQ11_10690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="388" mass="42215" checksum="5B252207D61ED9E8" modified="2018-01-31" version="1">MSLDHRLTPEHEELRRTVEEFAHDVVAPKIGDYYERHEFPYEIVREMGRMGLFGLPFPEEYGGMGGDYLALGLALEELARVDSSVAITLEAGVSLGAMPIFRFGTEEQKRQWLPKLCSGESLGAFGLTEPECGSDAGGTRTTARRDEATGEWVINGTKCFITNSGTDITGLVTVTAVTGRKEDGKPLISSIIVPSGTPGFTVAAPYSKVGWNASDTRELSFSDVRVPAANLLGEEGRGYAQFLRILDEGRVAISALATGLAQGCVDESVSYAGTRHAFGRPIGANQAIQFKIADMEMRAHTARVAWRDAASRLIHGEPFKKEAALAKLYSSEVAVTNAREATQIHGGYGFMNEYPVARMWRDSKILEIGEGTSEVQRMLIARELGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFZ6</accession>
    <name>A0A2G1XFZ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_21440</name>
        <name evidence="8" type="ORF">CYQ11_09345</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50147">
        <property type="protein sequence ID" value="PHQ50147"/>
        <property type="gene ID" value="BLA24_21440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13070">
        <property type="protein sequence ID" value="PPT13070"/>
        <property type="gene ID" value="CYQ11_09345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="632" mass="65887" checksum="5A9542D01FEFCD6F" modified="2018-01-31" version="1">MSKLADSEHAAGTGVGAPAAAGGEPPDTGAARTTAEDRHRLTATQGLAALSLDAMASVAYGPESIVLVLAAAGAHGLGCTLPVTLAIAALLTVLVASYRQVIAAFPDGGGSYAVAKRHLGRRTSLVTAASLVLDYVLNVAVSVTAGVAALTSAFPSLYGHRLWICLAVLVLVTGVNLRGIAESAKAFIVPTAVFVGSVLTVIVVGLFRDAPVSTQAAEGHASALAGDATAVGALLLLKAFAAGCSALTGVEAVANAVPSFRAPATRRAQRTEVALGALLGAMLIGLSLLIGRFHLQPVEGVTVLAQLADASLGHHWGFYVVQCATVVLLALAANTSFGGLPVLMSLLARDNYLPHVFALKADRQVHRHGVLALAAVSALLLVFSGGDVNTLVPLFAIGVFVGFTVCQVGMVRHWRRERSAGWRGKALLNGFGAVLTGVSAVVVTATKFTEGTWLIVFALPVLVLAFETVHRAYGRIGERLELGRVPEAPRRCHSVVVVPVSSLSRLTSKALTAAVSLGDEVVAVTVTQPDQEGRRAAESLRRDWELWNPGVDLVELPAATRALGRPIVDYVRELSGRHPDNRVTVLIPEVEPAHVWQRLLQNQRGAVVAHAVRRDTDAVICRLRFRVGAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG03</accession>
    <name>A0A2G1XG03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21575</name>
        <name evidence="3" type="ORF">CYQ11_09210</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50168">
        <property type="protein sequence ID" value="PHQ50168"/>
        <property type="gene ID" value="BLA24_21575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13048">
        <property type="protein sequence ID" value="PPT13048"/>
        <property type="gene ID" value="CYQ11_09210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="24984" checksum="3BB6F0CFBD1981BD" modified="2018-01-31" version="1">MIIAAAQFTARPLDVTANVARMAAVVTEAGERGAALVVFPELAVTGYELAAVAADPDRLAVDPDDPRLGPLRDACRAAGVAAVVNCAGRLPAGPTISSFVYGPDGAPLTRYEKQHVTAAEEAAGFVAGTRDGRFTLGGVAFGLAICFDAHFPDLAARAAADGCSVLLASSLYGRGGGAAERMAVFPSLARDNGLYVVLANHVGPAGPYDACGLSAVWGPDGEVLAEGPGDDTALVPARTGVRAPGAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG24</accession>
    <name>A0A2G1XG24_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21070</name>
        <name evidence="2" type="ORF">CYQ11_09715</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50089">
        <property type="protein sequence ID" value="PHQ50089"/>
        <property type="gene ID" value="BLA24_21070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13131">
        <property type="protein sequence ID" value="PPT13131"/>
        <property type="gene ID" value="CYQ11_09715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="10297" checksum="D45D5A8CB7BD3076" modified="2018-01-31" version="1">MRVTSAFSYSVPSDPVRHLLVLPDRDAAEEVAEEAARRFPLDDDPQVVREALAGEDDAEDAQWLVVVEDPDAALSAADLRVLAEEYDGWLETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG57</accession>
    <name>A0A2G1XG57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21705</name>
        <name evidence="3" type="ORF">CYQ11_09080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50191">
        <property type="protein sequence ID" value="PHQ50191"/>
        <property type="gene ID" value="BLA24_21705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13025">
        <property type="protein sequence ID" value="PPT13025"/>
        <property type="gene ID" value="CYQ11_09080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="191" mass="20457" checksum="4633D9504CBE31A1" modified="2018-01-31" version="1">MGVSLSKGGNVSLTKAAPNLTAVVVGLGWDARTTTGTDFDLDASALLTNDQGKVANDQNFVFFNNLKSPDGSVEHQGDNLTGEGEGDDEVIKVNLAAVPADVQKIVFPVSIYEAESRQQSFGQVRNAYIRVVNQADNTELARYDLSEDASTETAMVFGELYRNGAEWKFRAIGQGYASGLRGIAQDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG73</accession>
    <name>A0A2G1XG73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21950</name>
        <name evidence="5" type="ORF">CYQ11_08835</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50232">
        <property type="protein sequence ID" value="PHQ50232"/>
        <property type="gene ID" value="BLA24_21950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12983">
        <property type="protein sequence ID" value="PPT12983"/>
        <property type="gene ID" value="CYQ11_08835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758349" evidence="3">
        <location>
            <begin position="33"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="42358" checksum="EF3C3EA312A73AAE" modified="2018-01-31" version="1">MAPSFAVHARRGAAALATAAALGAGAAPAAFADGSPSPAASGLYGAKDPQFDGVFRQSLAFLAQDAVGVSPAPKAVDWLAGQQCADGGFAGYRADTGKACDANAGEFTDATSAAVQALAAVGGRAGAVQKGLEWLKTHQHEDGGWGMTPGGATDANSTSIAVGAFVAAGQDPAKAAVKGGKSPYDALLSFQLGCDKKEDERGAFAYMPQNGELLPNDLASAAAAQAALGKGFLTGPAAKGADRPVAPLDCAGDEKAKPKDAAAGAEAVAAYLAKKLDAGDNHLKSSMPGAPAGPDFGTTADATLALATGGHRNAAAKPLTWLQAKDNKAVEWAQGDPGRLAKLVLTAHAAGADPRDFGGTDLVKQLNETGPAPEKASASPEKKDEEKKDDGGGFGVWWFFGLFFVASVGVGFLLSGRKKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGG6</accession>
    <name>A0A2G1XGG6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22505</name>
        <name evidence="2" type="ORF">CYQ11_08285</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50322">
        <property type="protein sequence ID" value="PHQ50322"/>
        <property type="gene ID" value="BLA24_22505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12891">
        <property type="protein sequence ID" value="PPT12891"/>
        <property type="gene ID" value="CYQ11_08285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6340" checksum="BB79C7BC95893C35" modified="2018-01-31" version="1">MPQHTHALSRPCSHCDGFPAVAVTTGRTTPTGHRETITATCPACRGTGTSKIRPVLVAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGL7</accession>
    <name>A0A2G1XGL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20610</name>
        <name evidence="3" type="ORF">CYQ11_10170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50384">
        <property type="protein sequence ID" value="PHQ50384"/>
        <property type="gene ID" value="BLA24_20610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16467">
        <property type="protein sequence ID" value="PPT16467"/>
        <property type="gene ID" value="CYQ11_10170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7679" checksum="E1C0211494D553B2" modified="2018-01-31" version="1">MLLLMSSPAFALTRDDGDDPGPHLSTINTLGLYVAAPIVLFLVIAGLTMVLARGSDNPRTHAHHTHHPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGN1</accession>
    <name>A0A2G1XGN1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_21250</name>
        <name evidence="9" type="ORF">CYQ11_09535</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50404">
        <property type="protein sequence ID" value="PHQ50404"/>
        <property type="gene ID" value="BLA24_21250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16450">
        <property type="protein sequence ID" value="PPT16450"/>
        <property type="gene ID" value="CYQ11_09535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="193"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="440" mass="46999" checksum="CED31F9940540B59" modified="2018-01-31" version="1">MRLTILGGGGFRVPLVHRALLEDARRGAPGRCTELVLHDTDSARMRVIAAVLEARAAGVPGAPSVRMTDDLDDAVRGADFVFSAIRVGGTAGRVLDERVPLAEGVLGQETVGAGGVLYGLRTVPVALRIAERIAELAPEAWVINFTNPAGLVTEAMSAALGERVIGICDSPVGLVRRAARAAGADPERVGYDYVGLNHLGWLRGLSVDGRELLPGLLADDGALASFEEGKLFGARWLRALGALPNEYLHYYYFRRETLASVREAAQTRGEFLDRQQGDFFTGATAEPHRASELWERARLRREETYMAESRAASGGWERDSCDLEGGGYDRVAVALMRAIAGDESTRLILNVPNGTTVPALAPETIVETVCDVSAKGAHPVPCAPLREDQLGLMLQLKAVERATIEAALRPGSDAALRALALHPLVDSPAVAARILERAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGU6</accession>
    <name>A0A2G1XGU6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_16535</name>
        <name evidence="9" type="ORF">CYQ11_16750</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50452">
        <property type="protein sequence ID" value="PHQ50452"/>
        <property type="gene ID" value="BLA24_16535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14293">
        <property type="protein sequence ID" value="PPT14293"/>
        <property type="gene ID" value="CYQ11_16750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT14293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="42791" checksum="F4E254C26232457D" modified="2018-01-31" version="1">MIRFEHVTKRYADGTTAVDDLSFEVAEGELVTLVGPSGCGKTTTMKMVNRLIEPTSGRILVDGEDIATVDPVRLRRRIGYVIQQVGLFPHKTVLENTAAVPHLLGWQRKRARERAAELLDLVGLDPSVYGDRYPDQLSGGQRQRVGVARALAADPPVLLMDEPFGAVDPVVREHLQTEFLRLQSQVRKTVLFVTHDIEEAVRLGDRIAVYGNGRIEQLDAPAAVLGAPATPYVADFVGADRGLKRLSVTTIEAGDLEQPPVVHLDDRLSEAAERLDLEGARWAVVLDDSDRLHGWISAEAAQAAAGAGAVRVRDRARRMDAWLPLGASLKQAFSTMLQHDAGWIAVLDGESADHFLGVLTPARLHEALRRSIEADARGRSRSEAQVETVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX7</accession>
    <name>A0A2G1XGX7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16830</name>
        <name evidence="3" type="ORF">CYQ11_16455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50498">
        <property type="protein sequence ID" value="PHQ50498"/>
        <property type="gene ID" value="BLA24_16830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14247">
        <property type="protein sequence ID" value="PPT14247"/>
        <property type="gene ID" value="CYQ11_16455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="104"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="273" mass="28286" checksum="2C2B295A2CD305C5" modified="2018-01-31" version="1">MSTTADPLAALASLPGVADSVDSVRKAVDRVYGHRVMRRRSNEVTAEAALRGARGSAALSGADWALEEVRRRSDFGGEGEPRTVGAALRLTAEAGQLLSVWRQSPLRVLARLHLVAAGGDRPDETIGRPRLPGEPVEEPLLELALPGADEMSGRLEGLADLLIAGTEAPALVTAAVVHGELLALRPFGSYNGLVARTAERIVLVGSGLDPKAICPSEVGHAELGRAAYVAALDGYVSGTPGGMAAWIAHCAKAVELGVRESTAVCEALQRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH11</accession>
    <name>A0A2G1XH11_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16995</name>
        <name evidence="3" type="ORF">CYQ11_16285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50523">
        <property type="protein sequence ID" value="PHQ50523"/>
        <property type="gene ID" value="BLA24_16995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16604">
        <property type="protein sequence ID" value="PPT16604"/>
        <property type="gene ID" value="CYQ11_16285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="82" mass="8991" checksum="6817930759CF6AEA" modified="2018-01-31" version="1">MNAFLTAASFVVLVAAAAYLIHRLNIQHADRIAVHQYSARLPGRRGRGTPQPLVEPGRFASPTTGERQDYRDGGRGRTTHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHF2</accession>
    <name>A0A2G1XHF2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17645</name>
        <name evidence="3" type="ORF">CYQ11_15630</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50621">
        <property type="protein sequence ID" value="PHQ50621"/>
        <property type="gene ID" value="BLA24_17645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14124">
        <property type="protein sequence ID" value="PPT14124"/>
        <property type="gene ID" value="CYQ11_15630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="299" mass="32583" checksum="C1940B383E82C73A" modified="2018-01-31" version="1">MRLSTVILPDRRWSEGGRESWQRAEELGFDTAYTYDHLSWRTFRDGPWFGAIPTLTAAACVTSRMRLGTLVTSPNFRHPVTLAKELISLDDVSGGRVTLGIGAGGSGFDATALLKEGQAPWTPRQRADRFAEFVPLLDRLLTEDVVSYEGEHYSASEVRNIPGCVQRPRLPFAVAATGPRGMRLAARHGQAWVTTGDPKLFENGTPEQSRAAIAGQLERLGTVCAEAGRDVSELRKVMLTGFSPDRPLDSFDAFVDFAGAHAELGVEEIVIHWPIADSVFAADVAVFEKIATEGLAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK4</accession>
    <name>A0A2G1XHK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdhA</name>
        <name evidence="5" type="ORF">BLA24_18300</name>
        <name evidence="6" type="ORF">CYQ11_14975</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50734">
        <property type="protein sequence ID" value="PHQ50734"/>
        <property type="gene ID" value="BLA24_18300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14009">
        <property type="protein sequence ID" value="PPT14009"/>
        <property type="gene ID" value="CYQ11_14975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="59"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="381" mass="42001" checksum="FC814A547A183C3E" modified="2018-01-31" version="1">MTVDSTAARKPRRSSKRAGAKKAAGEPELVQLLTPEGERVEHPDYSIDLSPEELRGLYRDMVLTRRFDGEATTLQRQGELGLWASLLGQEAAQIGSGRATRDDDYVFPTYREHGVAWCRGVDPTNLLGMFRGVNNGGWDPNENNFHLYTIVIGSQALHATGYAMGVAKDGADSAVIAYFGDGASSQGDVAEAFTFAAVYNAPVVFFCQNNQWAISEPTERQTRVPLYQRAQGYGFPGVRVDGNDVLAVLAVTKASLDRARTGEGPTLVEAFTYRMGAHTTSDDPTRYRGDEERELWEAKDPILRLRALLEKEGLADEAFFASLEAESDALAKRVRDTVRSMPDPEDLAMFEHAYADGHALVDEERAQFLAYQASFADEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHQ9</accession>
    <name>A0A2G1XHQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18495</name>
        <name evidence="3" type="ORF">CYQ11_14785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50765">
        <property type="protein sequence ID" value="PHQ50765"/>
        <property type="gene ID" value="BLA24_18495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13977">
        <property type="protein sequence ID" value="PPT13977"/>
        <property type="gene ID" value="CYQ11_14785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="220"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="35590" checksum="56D2ADB99FA0AC5E" modified="2018-01-31" version="1">MSRTICAPAAHAAALPRLTTTVPREFVHRAAVAEVLLTGWRREGEDRFLVTAQWPRGHSFFTPVAGAGGRRHDPMLVTETIRQVGSLIAHAEFDVPLGYQFLMWDLSVTTHPERLAVGPVPAELVLEVRCSDVRRRAGTLAGLRYDVVLRRDGAIAATGNASYTCASPEVYRRLRGNREPGLPTRTAPAVPPELVGRHSSFDVVLAPAASPAGGPADASAAGRAGRWLLRAEGDHPVLFDHPVDHIPGMVLLEAARQASAALAPAASAVTPASFTSSFHRYAELDLPCWIEAERDEPDAAGAFVSRVSGHQDGEPVFSCTITTTPPADPSVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHR0</accession>
    <name>A0A2G1XHR0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18530</name>
        <name evidence="3" type="ORF">CYQ11_14750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50772">
        <property type="protein sequence ID" value="PHQ50772"/>
        <property type="gene ID" value="BLA24_18530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13970">
        <property type="protein sequence ID" value="PPT13970"/>
        <property type="gene ID" value="CYQ11_14750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758355" evidence="1">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="142" mass="14301" checksum="31969091EE064F36" modified="2018-01-31" version="1">MIKKVVATAALAFSAVSATAGPALAAGDSQDVANANGAGQMYGNTWTGGYMSPQMGLINGSLNKPCIAIGKLGVQSLIGLLNIGIQDVPILSSQQQQQCTENSTINDGDDPLSHILDDIPIISGNGSGNGDDLFGGLGHGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHW2</accession>
    <name>A0A2G1XHW2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">BLA24_18810</name>
        <name evidence="11" type="ORF">CYQ11_14470</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50820">
        <property type="protein sequence ID" value="PHQ50820"/>
        <property type="gene ID" value="BLA24_18810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13922">
        <property type="protein sequence ID" value="PPT13922"/>
        <property type="gene ID" value="CYQ11_14470"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="299" mass="33303" checksum="3A98FE2A9A85A1B2" modified="2018-01-31" version="1">MSGFVEKPKPVEVPGLVHLHTGKVRDLYRDENGHLIMVASDRMSAYDWVLPTEIPDKGRILTQLSLWWFDRLADLVPHHVVSTELPAGAPADWAGRALVCRSLDMVPVECVARGYLTGSGLAEYRQTRTVCGLALPEGLVDGSELPSPIFTPATKAAVGEHDENVSYEETARQVGAETAARLRQTTLAVYSRARDIARDRGILLADTKLEFGFEGEDLVLADEVLTPDSSRFWPVDTWQPGRAQPSFDKQFVRDWLSSPESGWDRHGELPPPELPEEIVERTRAKYAEAYERLTGTPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHX1</accession>
    <name>A0A2G1XHX1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18995</name>
        <name evidence="4" type="ORF">CYQ11_14285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50842">
        <property type="protein sequence ID" value="PHQ50842"/>
        <property type="gene ID" value="BLA24_18995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13900">
        <property type="protein sequence ID" value="PPT13900"/>
        <property type="gene ID" value="CYQ11_14285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="303"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="408" mass="40470" checksum="F149EBF48F803839" modified="2018-01-31" version="1">MASNGSGFDGSSYEPHDPYDPYDPSAEWNPAEETAAPSGRGRHRVVKQRGGTVARGSAVLGVGVIAAVGAGGMASAQDRPAAPISVPDLVQGIPGVGALIGGGEERDSASGAGSEAASGTGESGASDGFRDARGSGGAGGSHDRSGAREDSGAGEAGVTVAATRDAADAGEVLRARILQQAERQQAAAEEAALDKEAHAAAETHRKAAAERVEAFEAERAEAEAEAEAAAARVEKEEAQAPVGGGGAQTAGHAAGHAAPGKRQAAPASGRTAPRGALGAYTLPVGSYTLTAGFGQAGNMWSANHTGEDFAAPTGTPVKAVGGGTVTQAGWAGAYGYRIVLTLDDGTQLWYCHLSSMVVTSGKVAPGTVIGRVGATGNVTGPHLHLEVRPGGGAPVDPLSWLRGRGLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI15</accession>
    <name>A0A2G1XI15_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA pyrophosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Coenzyme A pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16880</name>
        <name evidence="4" type="ORF">CYQ11_16405</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50867">
        <property type="protein sequence ID" value="PHQ50867"/>
        <property type="gene ID" value="BLA24_16880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16607">
        <property type="protein sequence ID" value="PPT16607"/>
        <property type="gene ID" value="CYQ11_16405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="219" mass="23644" checksum="1283980E1D74D28D" modified="2018-01-31" version="1">MTVTAAGLPEWLTPVERAARTVEPHQLSRFLPPETGGRPSAVLVLFGEGEQGPELLLLERAGNLRSHAGQPSFPGGALDAEDGDPQGDGPVRAALREAEEETGLDPSGVQVFAVLPRLYIPVSGFVVTPVLGWWRKPSPVTPVDPRETARVFAVPVAELTDPGNRATAVHPRGHVGPAFLVGSAMVWGFTAGVIDRILHYAGWERPWDRDRRVPLDWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI45</accession>
    <name>A0A2G1XI45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18105</name>
        <name evidence="4" type="ORF">CYQ11_15170</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50895">
        <property type="protein sequence ID" value="PHQ50895"/>
        <property type="gene ID" value="BLA24_18105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16576">
        <property type="protein sequence ID" value="PPT16576"/>
        <property type="gene ID" value="CYQ11_15170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="53196" checksum="34B810825DCF94A7" modified="2018-01-31" version="1">MSLSLRFAAGSHKGMIREGNEDSGYAGPRLLAIADGMGGQAAGEVASSEVISTLVTLDDDVPGSDILTSLGTAVQRANEQLRVMVEEDPQLEGMGTTLTALLWTGQRLGLVHVGDSRAYLLRDGVLTQITQDHTWVQRLVDEGRITEEEATTHPQRSLLMRALGSGDHVEPDLSIREVRAGDRYLICSDGLSGVVSHQTMEETLASYQGPHETVQDLIQLALRGGGPDNITCIVADVLDVDGGDTLAGQINDTPVIVGAVAENQLHINDNGAMQTPAGRAAELGRANRPAPPQDGVSGGFGPPGSGDPAVGAAPDGSFGPFTDQDFVKPRPKGRWLKRSLIIALVLGVVGGGCYAGYQWTQTQYYVGAKDNDHVAVYRGINQDLAWLSLSKLAKDHPEIELKYLPVDQRSRVVDTIAVGSREQAEKKADELGKQASACKKNAERQTAEQQKRENEKQNGDRTGAAKDSGTESRAQATPAPGPTLSEEEQKLVQQCSNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIF6</accession>
    <name>A0A2G1XIF6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">BLA24_14780</name>
        <name evidence="7" type="ORF">CYQ11_13290</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030368403.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51042">
        <property type="protein sequence ID" value="PHQ51042"/>
        <property type="gene ID" value="BLA24_14780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13735">
        <property type="protein sequence ID" value="PPT13735"/>
        <property type="gene ID" value="CYQ11_13290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="61" mass="6979" checksum="AEB8EEBBEECDB444" modified="2018-01-31" version="1">MAKKSLIAKAARKPKFGVRAYTRCQRCGRPHSVYRKFGLCRVCLREMAHRGELPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ7</accession>
    <name>A0A2G1XIJ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14950</name>
        <name evidence="3" type="ORF">CYQ11_13120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51074">
        <property type="protein sequence ID" value="PHQ51074"/>
        <property type="gene ID" value="BLA24_14950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13703">
        <property type="protein sequence ID" value="PPT13703"/>
        <property type="gene ID" value="CYQ11_13120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="311" mass="34246" checksum="84116B7627F3895A" modified="2018-01-31" version="1">MDGDTPLHSIGALARLTGLTVKTIRFWSDAGVVPPAGRTPAGYRLYGPDALARLGMVRTLRELGVRLAVIRQVLEREVTVAEVAAVHAEALDAQIRMLRLRRAVLGVVAGRGSTPEEMELMHKLVTLSDQERRRLINEFVDSAFEGLDVDPGFLVTLRNSVPELPDDPTPAQIDAWVELVELVQDDDFRAGMRRAAADQIAALEEVGQPDQEAAKRFATALRERTAAAREAGIEPDSQAARPVVEELVRQCARLTGRADGPEFREWLLRRLKAGNDSRYEHYWRLISVINGWPAPDMGPAVAWLAAALRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIL3</accession>
    <name>A0A2G1XIL3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplJ</name>
        <name evidence="9" type="ORF">BLA24_14655</name>
        <name evidence="10" type="ORF">CYQ11_13415</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51021">
        <property type="protein sequence ID" value="PHQ51021"/>
        <property type="gene ID" value="BLA24_14655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13756">
        <property type="protein sequence ID" value="PPT13756"/>
        <property type="gene ID" value="CYQ11_13415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="176" mass="18461" checksum="1FA23C54AD5E1480" modified="2018-01-31" version="1">MATSAKAAAVAELTDKFRSSNAAVLTEYRGLTVAQLKTLRRSLGDNAQYAVVKNTLTKIAANEAGFQLDDQLFAGPTAVAFVTGDPVESAKGLRDFAKDNPNLIIKGGVLDGKALSADEIKKLADLESREVLLSKLAGAMKGKQSQAASLFQALPTKLVRTADALRAKLAEQGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIW5</accession>
    <name>A0A2G1XIW5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_14975</name>
        <name evidence="7" type="ORF">CYQ11_13095</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51079">
        <property type="protein sequence ID" value="PHQ51079"/>
        <property type="gene ID" value="BLA24_14975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13698">
        <property type="protein sequence ID" value="PPT13698"/>
        <property type="gene ID" value="CYQ11_13095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="18103" checksum="59C53ED0E1F5E6CC" modified="2018-01-31" version="1">MNVPHDIPAAPVAQLTVKSAEDMRELGRRLAALLRPGDLVLLSGELGAGKTTLTRGLGEGLGVRGAVTSPTFVIARVHPPLGGGPALVHVDAYRLAGGLDEMEDLDLDVSLPESVIVVEWGDGKVEELSEDRLRVVIERAVGDDAPADDADDVRSVTVTGVGARWAAADFGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ07</accession>
    <name>A0A2G1XJ07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15875</name>
        <name evidence="3" type="ORF">CYQ11_12200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51232">
        <property type="protein sequence ID" value="PHQ51232"/>
        <property type="gene ID" value="BLA24_15875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13544">
        <property type="protein sequence ID" value="PPT13544"/>
        <property type="gene ID" value="CYQ11_12200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18532" checksum="789FCA7EC5495F77" modified="2018-01-31" version="1">MEDEVDRLVAAWRRERPDLDVEPLEVLSRVSRLARHLDRARRIAFAEHELEPWEFDVLTALRRAGAPYQLSPGQLLTQTLVTSGTMTNRIDRLAKKGLVQREPDPSDRRGVLVRLTDEGRDRADQALAGLLAQEHAILAELSTAQRADLAALLRQLTAPFDNVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ59</accession>
    <name>A0A2G1XJ59_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16080</name>
        <name evidence="3" type="ORF">CYQ11_11995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51266">
        <property type="protein sequence ID" value="PHQ51266"/>
        <property type="gene ID" value="BLA24_16080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13508">
        <property type="protein sequence ID" value="PPT13508"/>
        <property type="gene ID" value="CYQ11_11995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304926" evidence="1">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="28415" checksum="0CA27FB3AFC2DA96" modified="2018-01-31" version="1">MSAMSLALLLAAGAAAAAGVAALYSTRGLRRQITALRAELAAATAERQRGRAAVPPARSAPAAELSEIRAAVADALAEERERELAEARAFWAAQEARDLAGAADSPSLLGGLPGLGDEPLAEGPYGGLFLPRPADFAGLDPLADPLGEVESDVADSPELAAARRRHPSHPDFSPVPAPTDHELTVDRLTALADAGIPLADVRPGPLGTLDVYVFADGTTVCMTPGHRETSERLAEALRAGDAPVLLGGSGVSGAYALTFRCETGSVYVLADRVIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ71</accession>
    <name>A0A2G1XJ71_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16320</name>
        <name evidence="6" type="ORF">CYQ11_11755</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51304">
        <property type="protein sequence ID" value="PHQ51304"/>
        <property type="gene ID" value="BLA24_16320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13470">
        <property type="protein sequence ID" value="PPT13470"/>
        <property type="gene ID" value="CYQ11_11755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="79"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="355"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="473" mass="50107" checksum="2E5491C854ECA7E8" modified="2018-01-31" version="1">MRLATGAAVAVLGTGGIGHAVVYGIDGGIGRVDPFGGLSNRPGGGRGMNVLLVGTDGREKITEDERRRYHLGGVPCHCTDTMMLMHLSADRERATVISLPRDTYTEIPEHADETGGVRPAHPQKLNAAYAEGGPGLTVRAVEQLTGVHVDHYMEIDFTSFMKTVDVVGGVQVCTVRPLKDDYTGLDLPAGTSTLDGGQALQYVRSRHLDGAADLGRMQRQQRFLASLIHKVSDGRLLLNPVKFQEVTSAVLDSVRADRGFGADQLLELGRAMRKLRPASAEFTSVPVAVANYPVAQIGSTVRWDEAAAGKLFQALREDRPVNAVPRAPHRTQDAKPPSRRDGPAPTAVEVAPERIRVQVLNGSGVDGLGRTTDEALRATGFATTGLPAGAPPPADGHTVIGYDPRWDRSAHSLAAALPGAELRPVPGQGPLMKVVLGTDDPRVRPVRAQDPPPQHGGGVPVVTGDQVICPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJJ8</accession>
    <name>A0A2G1XJJ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15285</name>
        <name evidence="3" type="ORF">CYQ11_12785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51351">
        <property type="protein sequence ID" value="PHQ51351"/>
        <property type="gene ID" value="BLA24_15285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16525">
        <property type="protein sequence ID" value="PPT16525"/>
        <property type="gene ID" value="CYQ11_12785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="60" mass="5999" checksum="0D7D003E32CB57B7" modified="2018-01-31" version="1">MGEEGHGGFIDTGGGSCVSVAPLTDQVAVRDSKQRNGPTFVVPATAWTAFVGGVQAGHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJM3</accession>
    <name>A0A2G1XJM3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_13935</name>
        <name evidence="7" type="ORF">CYQ11_01630</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51427">
        <property type="protein sequence ID" value="PHQ51427"/>
        <property type="gene ID" value="BLA24_13935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11768">
        <property type="protein sequence ID" value="PPT11768"/>
        <property type="gene ID" value="CYQ11_01630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="524" mass="56378" checksum="54BA09100FBBFEF5" modified="2018-01-31" version="1">MRDEIHDYIVVGAGSAGCVLAARLSEDPGVRVLLVEAGPVDDAPEIHIPAAFAKLFRTKYDWDYSTEPEPGLGGRRRYLPRGRTLGGSSSMNAMIYIRGNRRDYDAWSDAGAKGWSWDEVLPYFLRAEDHHGGPSQWHAVGGPLPVSEGRSLSPLMAAYVEAAQQAGHPFNPDFNGPEQDGVGFYELTQRNGLRCSTADAYLRPAMERPNLTVLPDTQCTRLLFSGDRAVGVAAERHGEALHLRAGREVVLAAGAYNSPQLLMLSGIGIAAELAALGITSRVDLPVGENLQDHGHIPLIHLTDTESLMAAESPENIALLESEGRGPLTSNAGEAGGFVRTRDDLDAPDVQLHAVPAMFHEEGLAAPVAHGFHHGAVLLDATSRGKVSLRSALPSAKPRILHRYLSTEEDRAAAVRALRVLLAIADAPALRAHRRSDHLVPRSDGDADLLDFARRELHTLYHPAGTCAMGPVVDYELRVHGVRGLRVADASVMPTLVRGNTNAPTIMIAEKAADLIRGVESVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJP2</accession>
    <name>A0A2G1XJP2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BLA24_13905</name>
        <name evidence="15" type="ORF">CYQ11_01600</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51455">
        <property type="protein sequence ID" value="PHQ51455"/>
        <property type="gene ID" value="BLA24_13905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16285">
        <property type="protein sequence ID" value="PPT16285"/>
        <property type="gene ID" value="CYQ11_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304961" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="29"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="56"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="276"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ51455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT16285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="472" mass="52413" checksum="A3A7EB676D929B3E" modified="2018-01-31" version="1">MRARGRFRCSRRGLLTAAAALPLTAAAGALAGDEAPRPPDGRRYFPRHGSYGHRTVSYDLRLDYDPGRAWLEGHARVQAVALEPAREVELDLARLKVRSAHFDGRPVEVRRRSGKLVLRAPRPLAGEQPFVLDIRYAGRPAPVASPFGGVGWDRTGDAHDGTLVASQPVGAPSWFPCNDRPDDKAAYTFAVTVPRGHHALANGTLLRRVSEGDRVRWTYHHPGPMATYLAAVYTGRFTHEERDGVRNAYPAHLADRARHDLARQPEMLRAFAGLFGPYPFDSYGAVVVDAELGAPVENQTLSVFGSNHIDGRRGWETLVAHEIAHQWYGNSVTLADWQHIWLNEGFATYAEWLWSEHLGEDDAHALARQAWHGLSAGRQNLRIADPGSGHLFDDRVYVRGACTLHALRTAVGDDRFFTVLRTWHAAHRGGNADTCAFLAHAERVTGRELGPLLRPWLFEKRLPDLPDRDPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJT5</accession>
    <name>A0A2G1XJT5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13760</name>
        <name evidence="4" type="ORF">CYQ11_01455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51399">
        <property type="protein sequence ID" value="PHQ51399"/>
        <property type="gene ID" value="BLA24_13760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11739">
        <property type="protein sequence ID" value="PPT11739"/>
        <property type="gene ID" value="CYQ11_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305589" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="45"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="360" mass="38181" checksum="83FB9431A5D54C02" modified="2018-01-31" version="1">MTPDTAHPPRRPVSFLRVIAAALATCCVALGLMASPATTATAHAAGKCDTPLQCVDFTSVHNGRKLDVQNGSLGDGAIIVTNSAPGHHQSWQLNVDATDSSFTIVNNTTGKCVDLSWPALRQQTCRGQKTQKWYFQPVTGASDAFMIRNESDNSCLDLVAGAQYDDAWTGKSACHGGTNQRWTTTAEARALAVDHAAYRCQRNTSTCSWAVRNIAGAAPLPKVCASSVWYNNTGGPISQTFSVNKTTGWSNSIGNHLTAQFGTGGMEPLMAMVNSSLDFTNTWTGSSSVDNAVTVPVPAGQYGWVTLSVLAKKVTGTWTFDTQGFPWKADDTITVPLKDDPSGGATLYIANTSPTFTSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJT7</accession>
    <name>A0A2G1XJT7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_14005</name>
        <name evidence="14" type="ORF">CYQ11_01700</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51441">
        <property type="protein sequence ID" value="PHQ51441"/>
        <property type="gene ID" value="BLA24_14005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11782">
        <property type="protein sequence ID" value="PPT11782"/>
        <property type="gene ID" value="CYQ11_01700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="12">
        <location>
            <begin position="105"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="11">
        <location>
            <begin position="220"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT11782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="314" mass="33166" checksum="4526E0C970F4DA06" modified="2018-01-31" version="1">MTAAIVGIGAELPPRTVPNSDFTHLDTSDEWITKRTGIRERRFLAPDGHLADLALAACRQALSAAGCAARDVRHIVVATTTPDRVTPGLAVEVATRLGMPQAAAFDLHAACAGFVYALDHAAALIESGRAEAVLVCGAEALTRITDRDDRSTAVLLGDGAGAVLLADVPDAPRPRFFLASDGEGIPLLYADRHERVLRMDGREIFVHAVEKMTAATRRVLEHQALKSDDLDLFVAHQANARIVRAVGKELGLSDDRLFLNVDRVANTSSASIPVALAQARHEGRLGGAGLLGLAAFGAGVTWGAGVVGWRLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJY6</accession>
    <name>A0A2G1XJY6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12675</name>
        <name evidence="4" type="ORF">CYQ11_17030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51553">
        <property type="protein sequence ID" value="PHQ51553"/>
        <property type="gene ID" value="BLA24_12675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14343">
        <property type="protein sequence ID" value="PPT14343"/>
        <property type="gene ID" value="CYQ11_17030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758503" description="Amidohydro-rel domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="126"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="512" mass="55182" checksum="0F83E4D3B9EF6FCF" modified="2018-01-31" version="1">MCVCGRRQFLGSTAVLAGAAALDSAGTATAAEAPAPAPTAEQDHTLALIHATLLAAPGVRPPEHDATVLVRGDRVVATGPTAQLQVPPGARVVDLTGKHVIPGLIDAHAHSGGPEGVHPPLYPLLGVTTVREMWGTPTVRAWRDKVNAGRLLGPRWVIASTIVDSPPGLWTSDIWPVPTIEVRTDAEARSTVRRIRAEGADFIKVYSRLTREAYFALADEALRWGVPFAGHCPDAVTVSDASDAGQHSVEHLHPLLLSTSSKEEEIRRRLDAVRVNPRDPSTMSRVRGWFHAVHDLESAATRSYDPGRAHRLFDRLAANGTYVTPTLVTHHTMERPETLPSSDPEWTYLPRRQTAAWPAQLKELTGERTPEESAHLRDVNAHRTRLVGEMRRRGVPVLAGTDTGTSYLVPGFALHHELRRLTEAGLTPAQALQAATVEPSRALGTATEAGTVEPGKAADLVVLDADPLHDIRNTLRIDSVLTRGRLIDAAERRRLLAEVAEAAAAATPPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK36</accession>
    <name>A0A2G1XK36_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12935</name>
        <name evidence="4" type="ORF">CYQ11_17295</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51597">
        <property type="protein sequence ID" value="PHQ51597"/>
        <property type="gene ID" value="BLA24_12935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14390">
        <property type="protein sequence ID" value="PPT14390"/>
        <property type="gene ID" value="CYQ11_17295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="36701" checksum="CB462238A43985AA" modified="2018-01-31" version="1">MTETPRTGGPQHPAPQQSPGPYPAPPAQPPRQPFRTASGVTVWPGEGTAHAGDGHGGGGLPGGGPTGFPQEGPVPAGRSGAGHAAPRRARGPVALLAACALVAAVVGGGSAALVSELTGGSRASASHATPVQNVAAKNGGVAAVAKAVSPSIVEIKASTPSGQSTGSGVIVTADGEVVTNNHVVAGADTVRVTLGDGTAKTAKVVGTDPDKDLALVKIQNAEGLKAAALGDSGQVAVGDQVVAIGSPEGLTGTVTSGIVSALNRDVTVSKEQDRGRQRQGTPQWPFEFGGNQYNGDTGSTRTTYKALQTDASLNPGNSGGALINMSGEIIGINSAMYAPSTASGSGGSAGSVGLGFAIPVNTVKADLAKLRAGGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK39</accession>
    <name>A0A2G1XK39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12975</name>
        <name evidence="3" type="ORF">CYQ11_17335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51605">
        <property type="protein sequence ID" value="PHQ51605"/>
        <property type="gene ID" value="BLA24_12975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14398">
        <property type="protein sequence ID" value="PPT14398"/>
        <property type="gene ID" value="CYQ11_17335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758497" evidence="1">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="161" mass="17672" checksum="EE8F7E29637721A8" modified="2018-01-31" version="1">MQRRTVLRTLTTTVATAALGLAVAQGATASAATPPSQDTTAKATTSADDNPFRWMDLDGLRAEYRFMCPAGHCVGYWSLVLADEVAQRRYAGGEFFVYAPATGEFGFFLNTDIASRTVKKPAQVRVVDSDFTRSHPRFEIRYGNPDQPKKARVVATATTWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK85</accession>
    <name>A0A2G1XK85_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12375</name>
        <name evidence="6" type="ORF">BLA24_12380</name>
        <name evidence="4" type="ORF">BLA24_12580</name>
        <name evidence="7" type="ORF">CYQ11_17455</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000138">
        <property type="protein sequence ID" value="PHQ51671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000138">
        <property type="protein sequence ID" value="PHQ51672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51658">
        <property type="protein sequence ID" value="PHQ51658"/>
        <property type="gene ID" value="BLA24_12580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51671">
        <property type="protein sequence ID" value="PHQ51671"/>
        <property type="gene ID" value="BLA24_12375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51672">
        <property type="protein sequence ID" value="PHQ51672"/>
        <property type="gene ID" value="BLA24_12380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14417">
        <property type="protein sequence ID" value="PPT14417"/>
        <property type="gene ID" value="CYQ11_17455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="27"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="412" mass="46257" checksum="4981802D28821915" modified="2018-01-31" version="1">MSFARRGDLDGGRTAVQRSTAKPRLYVLDGFRLVAALMVVAFHYIALRGGWDRNTAEIFPQLKPFAQYGWLGVEVFFLISGFVICMSTWGRRLGDFVVSRACRIYPAYWVAVFLTATVITLWPQVRSVKGWDVVATNLTMLQQGMGVWDVDGVYWTLFIELKFYILFAIVVATGVTYRKCVLFCALWTVAAITAPSVDSKLLDMWAMPLASPYFVAGIAFYLMYRFKPTALLWGIVGVSFLLALHGVPKRVADNQDHVIPHWPAKLIILAAFVMMALIAYGKLNRIQWRWLTTAGALTYPLYLLHQYIGLTMIHWLQHKVQPGVLVLALTAVMLGAAWLMHRFVERPFGTKMRNALQKGIEDMRRNSSPAPEAAAGKPGGPLEATLPPVQEPRRFEHAETAPQAPAFHHRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK94</accession>
    <name>A0A2G1XK94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF461 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000138">
        <property type="protein sequence ID" value="PHQ51674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51674">
        <property type="protein sequence ID" value="PHQ51674"/>
        <property type="gene ID" value="BLA24_12345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013787122" evidence="1">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="121" mass="12034" checksum="3752E0DACDC7C3BA" modified="2018-01-31" version="1" fragment="single">MSSSLRRGALAATALVLSIASLSACAAGNKAQTLGVKPDNAATSVGDIKLQNVNVITQPEQNASGPAVITGRVFNNGIKDQELRSIKLPGKDVTVKLTPAKGASGALVVPAGGSVTLGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL7</accession>
    <name>A0A2G1XKL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11845</name>
        <name evidence="3" type="ORF">CYQ11_03085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51770">
        <property type="protein sequence ID" value="PHQ51770"/>
        <property type="gene ID" value="BLA24_11845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12017">
        <property type="protein sequence ID" value="PPT12017"/>
        <property type="gene ID" value="CYQ11_03085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="134" mass="14804" checksum="66A8026669EB76A5" modified="2018-01-31" version="1">MWKCEVIDAADLDVAEVAELYRASGLAERRPVEDTERFTAMVRNANLVVVARVDDRLAGIARCVSDRSYVTYLSDIAVDRAHQRRGIGVDLIRHVQQAAPQAKIVLLSAPAATEYYPHIGFTQHGSAWVLDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKQ5</accession>
    <name>A0A2G1XKQ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_12080</name>
        <name evidence="2" type="ORF">CYQ11_03320</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51812">
        <property type="protein sequence ID" value="PHQ51812"/>
        <property type="gene ID" value="BLA24_12080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12058">
        <property type="protein sequence ID" value="PPT12058"/>
        <property type="gene ID" value="CYQ11_03320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="166" mass="17924" checksum="7151DD7C00C225AE" modified="2018-01-31" version="1">MSFLRRRSAATPTGPDFDVLAMDPGDWPGDLGAGLLPAPDGSCQGVFLRYDLFGGRGPAMIIGNLPEGSPARELAEGQVPFEVAQLLAALGNDEPVEVVGTEDVPVMHEDNLLIVRRLKCSESRISCTQFDRSDGVLVTIASWDRPITDDLYQLLKPLPAEMFRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKT9</accession>
    <name>A0A2G1XKT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycosyl transferase, family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_12220</name>
        <name evidence="12" type="ORF">CYQ11_03460</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51836">
        <property type="protein sequence ID" value="PHQ51836"/>
        <property type="gene ID" value="BLA24_12220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12083">
        <property type="protein sequence ID" value="PPT12083"/>
        <property type="gene ID" value="CYQ11_03460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="155"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="601" mass="65136" checksum="6E64C59115EC9C83" modified="2018-01-31" version="1">MVLGHPCLWTGVGVPEQARCRRLPGPVRSPGPAREPRDGPVGPGPRSPLVYARHPVVAGRKPHPRTGRPTTPAGGCACPRALTRKRKPVTSTISVTTQRPGRLPDAPPPLARKPVLTIAAALGVVLLLTSGRYGYFGDELYFLGAGKHLDWSFADQPPLLPAMAHLMDALFPNQVMGLRLPATVAVALGTLPAALLAREFGGARRAQVLSSAAYAVSLYTLWTGHLLATSTFDLVLWMLVSWLVVRWVRLHHEGVRADRLLFLAGLATAVDLQVKYLIPVFWAVLAVSVLLTGPRALLTRPLLWAGAAVAVAVSVPALVWQARHGWPQLAMGGVISSANQQSGALLSRLAIVPYVLVLAGLLTGAVLLCYGLWCLLRVPRLRPYRFVAWTALGVLLVFVVMAGRPYYVAGLFSPLWAAAAAELERREPAKWWRWAATAPAFVVTGLLSVALALPVLPVSAVDPTDGLMSNPGSVGWPNLVSKVADAYRRLPAGQQRTTVAMGEAYWQGGALDHYARQYKLPPVYSANRGYWYFGPPPADTTTVLHVTAFPERLRAFFDEVRPAASVHNPHGIPVLNSELGVYVCERPKLPWPQLWDKMKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU4</accession>
    <name>A0A2G1XKU4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11405</name>
        <name evidence="3" type="ORF">CYQ11_02640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51847">
        <property type="protein sequence ID" value="PHQ51847"/>
        <property type="gene ID" value="BLA24_11405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16311">
        <property type="protein sequence ID" value="PPT16311"/>
        <property type="gene ID" value="CYQ11_02640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="473" mass="48673" checksum="2BA95DB7647A4C6A" modified="2018-01-31" version="1">MTKTTLLLRDGRALAALAVPLVLTQLAQVALTTTDTVMMGLLGATDLAAGGLAIVIFNQLRTMGVGLVTSVGNRIAAAHARAEAAPDGTGPGTGGSDAEVRRVVRAGMAVATLAGLAGALLMAGAGQVLGLAGQDPEVADRARTMLFALAPGLLPCLWFQAVRQFTVGMRRPQALLRITIASVAVNAGLDWAFLHGSWGLPRLGLPGVGLATTLVHALSFLALYACARRDPVLAPLLALNPARADRATVRRLLGLGVPIAATYGSEAGFFSVTALMAGSFGPAALAAHTAVNQLVYIVFQVAVGLSHAASINVSRELALGRFDAARRIRNTALACAAAVMAVVAVVYLALPSLVLRPFLDTGAGADAEAVRIATRLLLVVAVLQFFDCAQNIGVGLLRGLDDTRSGFRITLVGYWLVGLPAAGLLGYALDLKTLGVWLALLAGLATTAVLLLRRYGRSLAHRSAEGVAEPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLG2</accession>
    <name>A0A2G1XLG2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protease inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_09185</name>
        <name evidence="12" type="ORF">CYQ11_27795</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52088">
        <property type="protein sequence ID" value="PHQ52088"/>
        <property type="gene ID" value="BLA24_09185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16168">
        <property type="protein sequence ID" value="PPT16168"/>
        <property type="gene ID" value="CYQ11_27795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="5 8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304948" evidence="9">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="34"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="129" mass="13460" checksum="587A6C6091E9EA93" modified="2018-01-31" version="1">MSVRTQAAAVAAATALLALPPAPAAADDQNDGRLFLTVSGSQNTWIRGIRLICPAADGHHPHAADACKALALAHGRLEELPEASRTCAPSRDPVTATADGDWHGAPVAWRRTFPNTCALEAATGPVFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLH2</accession>
    <name>A0A2G1XLH2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TIGR03621 family F420-dependent LLM class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09085</name>
        <name evidence="3" type="ORF">CYQ11_27695</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52070">
        <property type="protein sequence ID" value="PHQ52070"/>
        <property type="gene ID" value="BLA24_09085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16150">
        <property type="protein sequence ID" value="PPT16150"/>
        <property type="gene ID" value="CYQ11_27695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="31695" checksum="BA2C12690095CCC3" modified="2018-01-31" version="1">MSRPFRFAVNMLTGCTAAEWRAKCRQAESMGYDVILVPDHLGMPAPFPSLVAAAEATERPRVGTLVLNAGFWNPALLAREVATTDQLTGGRLELGLGTGYVKAEHDSAGLPFGSPRERVDHLEHTVTELNRLLGDPGHLPATTQAPRPPLLLGGNGDRVLRLAARHADIMAFAGGGSNPDGSLRLVSPSELAGRVAAYQGFAADRPEPAELNYLVQVVAVGGDPLTKVRELMGYRTDLTDEEYLAHPALLTGSVKEIAERIRGHRERYGFTYFTILEPYMEAFAPVIEELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLI4</accession>
    <name>A0A2G1XLI4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000115">
        <property type="protein sequence ID" value="PHQ51989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51989">
        <property type="protein sequence ID" value="PHQ51989"/>
        <property type="gene ID" value="BLA24_10285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="127" mass="13688" checksum="F834FC34318F4411" modified="2018-01-31" version="1" fragment="single">MVEQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIITECGPLPAQAVRWLAAGVAEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM40</accession>
    <name>A0A2G1XM40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000087">
        <property type="protein sequence ID" value="PHQ52312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52312">
        <property type="protein sequence ID" value="PHQ52312"/>
        <property type="gene ID" value="BLA24_08265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="275" mass="28363" checksum="23E6227AECD080D6" modified="2018-01-31" version="1">MRSVPIGGVRVRRGSRVRLRPVGRADVLDPSLTGRVAEVTELTEDLEGRVQLVVSLDGDAGRDFATGLGHRFFFSPEEVEPVVGETAPPTARVLIAGIGNVFLADDAFGPEVVAALRRRPVAAGVHVADFGIRGMDLAHRLLDGYDVAVFVDAAPRGGAPGTLYLIEPAPVDAAAPAPPDAHGMDPVRVLALAHRLSAAGQGGAVPRVVVLAASRWCACAATSPRSPSASANPCGPPSGGGALARIAHPRPAGRPARPLGRGAPRPRGPLKPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM59</accession>
    <name>A0A2G1XM59_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07690</name>
        <name evidence="3" type="ORF">CYQ11_00120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52332">
        <property type="protein sequence ID" value="PHQ52332"/>
        <property type="gene ID" value="BLA24_07690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11536">
        <property type="protein sequence ID" value="PPT11536"/>
        <property type="gene ID" value="CYQ11_00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="202" mass="21929" checksum="A466D411C5E6CA9F" modified="2018-01-31" version="1">MASHPLDGNGHDTAVVVAHEIYGVNEHINGVAEMLSPYRCDVFTPSFLPPGVVYAREDEPRAYREFTRAPGVAGMGNALAQYTDGLRERYRRVLCIGFSVGATSTWLASETGAVDGAVCFYGSRIRDYLDIQPTAPCLVIFAEQEPSFSVPAVAERLAGRKGVVTEVHPCRHGFCDPGSPHYSAGHSRKAWTSATQFLGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMK7</accession>
    <name>A0A2G1XMK7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07990</name>
        <name evidence="3" type="ORF">CYQ11_00425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52379">
        <property type="protein sequence ID" value="PHQ52379"/>
        <property type="gene ID" value="BLA24_07990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11581">
        <property type="protein sequence ID" value="PPT11581"/>
        <property type="gene ID" value="CYQ11_00425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13840" checksum="7BFA651426E7BC50" modified="2018-01-31" version="1">MTTAAYDLGQRFHAALITGDWPAIRSMLHDDATWTLPGDNTISGTVVGADAVVERAQKIASYGLSFELLHVLVSRENMALSLHNTAQRPDAILDEYLTTVCRLRDGRIADIETYLSDVPGMNAFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMN4</accession>
    <name>A0A2G1XMN4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">egtC</name>
        <name evidence="2" type="ORF">BLA24_06940</name>
        <name evidence="3" type="ORF">CYQ11_27090</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52507">
        <property type="protein sequence ID" value="PHQ52507"/>
        <property type="gene ID" value="BLA24_06940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16042">
        <property type="protein sequence ID" value="PPT16042"/>
        <property type="gene ID" value="CYQ11_27090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="27630" checksum="9F62ADD0F6218582" modified="2018-01-31" version="1">MCRHIAVLGPKAPLGRHLMDPPYALVRQSWAPRRQCHGTVNADGFGVGWYAPGDPLPARYRRAGPVWADESFADLCRVVRSRALLAAVRDATLAGPDAEAAAAPFAGGPWLFSHNGALPGWPDCAAPLVSLLPPVASLRLAARCDSAFVWALVEHRLLRGERPGQALAGAVATLARAAPGSRLNLLLTDGASIAATTWGDSLWYLAGDGRTVVASEPYDDDPRWTEVPDRTLLTADRTGVTLCPLSSRVPRVPLKEPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMQ4</accession>
    <name>A0A2G1XMQ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_06845</name>
        <name evidence="4" type="ORF">CYQ11_26995</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52490">
        <property type="protein sequence ID" value="PHQ52490"/>
        <property type="gene ID" value="BLA24_06845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16024">
        <property type="protein sequence ID" value="PPT16024"/>
        <property type="gene ID" value="CYQ11_26995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="649"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="717"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="751"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="843" mass="94177" checksum="0FFF38A6AD80A9C4" modified="2018-01-31" version="1">MIARQHRSGIVGRQAELACFQDNLRQPPDDASHRFVFHLHGDSGVGKTFLLQQLISGARAQRALTACVSDSVRSVVDAMETVSAELAQQGFPLRKFDALLTAYRRKLHEAEALYHSAHPPPGRPVDRTRDGRGPQDGAPSATSRVAARIGLASLALVPGIGFVAGAVDAAEVAQATDRLREWLGGHFHNREDVELVMSPEKTLTPLFAEDLREAAARRPWVVLFFDDYECTAPVLDDWLRELLLSRVHGKLPANTVVALAGQQPLSYAGWGDHLGLVQHLPLDVFTEAEARQLLAAKGITDELSVGVILRESGRLPRQVALMAENGPDDPHSADVSGATVERVLKNIDDPVRRAAVRACAVPRRLDEEVYRAAVEPEAAVFSGWLRTLPFVTDHGGIWQYNEPIRAAFLRDERNRSPERWHDRHRALAGAFEEWRLRLEETLPPEDRWADDRWVEFALEERYHHLCAFPQSFLRTTARFLVDACACEPARIRRCADMLAQAGEAAGLEAARSLGQRLLAVLPDERADAVPALDTLLAEPGLDTAGRVAALVARGERHRRAGRAEEALADYRQALQLDPTCPRVFTGRGALHRAMGRLDESRSDFSRALELTPGDPAALAGRGATHRLMERYGDALADLQRAVAIRPELHWAHAERGWTYLATRQLDEARAAFTSALEHRPDDSRLFIGRASAHRYIGDYDLALADCGHALRLKPDSWWAHAVRGATYRLLERYDEAVADLTRAIDLRPDYDWCLAGRGEVHRREGRFVEALRDLDHALRIQPDNDWALARRGAVYCAQQRTQEALADFQRSWDNMPDYDWALIKPGQTYRLMGHEFDWYSAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNE3</accession>
    <name>A0A2G1XNE3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_05740</name>
        <name evidence="6" type="ORF">CYQ11_02215</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52767">
        <property type="protein sequence ID" value="PHQ52767"/>
        <property type="gene ID" value="BLA24_05740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11868">
        <property type="protein sequence ID" value="PPT11868"/>
        <property type="gene ID" value="CYQ11_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="19690" checksum="25B21C1AD79CAC18" modified="2018-01-31" version="1">MTWYVILVLAVAAERCAEVAVALRNARWSTARGGVEYGAGHYPVMVALHTGLLAGCLLEVALGRRAFVPPLGWTMLAAVAAAQALRWWCVHTLGRRWNTRVIVVPGLPLTTTGPYRLCRHPNYVAVVVEGVALPLVHGAWLTAVVFTALNALLLTVRIRCEDAALRTTAGVRAGAAAPPAEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNF1</accession>
    <name>A0A2G1XNF1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_05690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52758">
        <property type="protein sequence ID" value="PHQ52758"/>
        <property type="gene ID" value="BLA24_05690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="4">
        <location>
            <begin position="68"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="534"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="1041" mass="113306" checksum="F8222A0FB7818948" modified="2018-01-31" version="1">MTPTGSEGPGEPVRRSRRGAVRLRTLLVWLAVVPTVAMGAQVLISSDRSVQESRHLRKDVMAGRQTGVPLYRLMTTLQSERAVTAAWWSGMPVSSAELRDRRADTDRAVAVFLKSSDADQLHSDRAKDRLRDVARRLADLGALRERANARHGSPDDAVDYYTDVIGGTIRCFGDFNHVDDGGLTQEATSLVALFSAAEVVAREDAILALSGPSGKLTSARFREFVEAVGASDYLYDTVALDLPLDDQDALQRILTSNAWQTKSRIENAIVSEHRDVSSGVVLPPDVRDWRAAYGTFSGQLDTLDESELKELLAHADERAAQLEDQVVLLVAASGAALLLVVAVVAFTTRTVLRRLRSLHDRTVAVAEETLPDVLDRLQRGEAVGSDALPRPEGEQDEVGRISDAFARVVAVSVEGHRKLADERQGFSVFASGIAARTGNLVSRQLALTEHIQDTYGQDEALLADLMRSDQLTVGMRRQIENLLILAGGEISDPHMEPMRIADLLREAAAEVEDFRRIDRHAMDETSVEAGVISQLSHLLAELLDNATRFSPPTARVAIRSELVGDGLCIEIEDRGPRVTAERYEEMNGRLHSAPPYSELASNAHRLGLFVVGHLADQLGATVTLRRSAFGGTSAVVIVPSEHLVPAREGTAVPEPAKEPAPVPRPAQPTEERRPKLVARQQTGDPAGDPAPGAPELPRRPRKERVRQAGNTAPETPPRSGSGDVPGRPALPSASPRPTSPSGSASRARTNRWAGTPPRPKRWPTPGRTTKTAPGKWNSSSEGTSHDDDTERCDLQHPGQQPEQDRGDPGSRSPLQRRAQTQRLHAGTGPGRTGGRGGLRHRVHHEGHLAGDRRRRSDPPTRRDGRPVPVHRRVRSGQHADRGGLPQGTARRAGRRDGPRRAGARRVAGHPRTLTGAHVVMAADPQPVRRRRTRLYALTDGRTTASRHGLTMDTVITAVADPGHGHGSLPTEWQEILAMCPSPNGRAVAELAARMRMRLTPMTVLLGELLERGLIRHRPPLDASETSNVHLLMKIRDNLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH7</accession>
    <name>A0A2G1XNH7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05925</name>
        <name evidence="2" type="ORF">CYQ11_02400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52797">
        <property type="protein sequence ID" value="PHQ52797"/>
        <property type="gene ID" value="BLA24_05925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11899">
        <property type="protein sequence ID" value="PPT11899"/>
        <property type="gene ID" value="CYQ11_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="31321" checksum="7B200DBF9D5F6CC6" modified="2018-01-31" version="1">MNHPDRLRAAVAAEGTTPLIGVFDMFSASVSAQHYDGMFISGFGFAASHYGLPDIGFIAWPDIVAFVQRLRLAFPEQHLLVDIDDGYVDPETACHTVQHLEAIGASGVILEDQKRPRRCGHVNGKQILPLEEYLEKLNLVLAARRDLVVVARTDATEESEILRRAKALAATDADVVLVDGVRSVEWIRKVRDVIGDKPLLFNQIAGGKSPRLSLPELSDLGVDVAIYSTPCLFAAQTAMDTALRRLKEDDGRLPEVTPSGVGVAECLALLEKNISRHHRREATVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNK2</accession>
    <name>A0A2G1XNK2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent carboxylate-amine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05550</name>
        <name evidence="4" type="ORF">CYQ11_02010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52817">
        <property type="protein sequence ID" value="PHQ52817"/>
        <property type="gene ID" value="BLA24_05550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16295">
        <property type="protein sequence ID" value="PPT16295"/>
        <property type="gene ID" value="CYQ11_02010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="114"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="408" mass="44750" checksum="046EECE2A4020042" modified="2018-01-31" version="1">MADDRAGSFTRYAARHLAGRLVLLRFAEVRRDLSEDYLRETAHLPAFWVREGVPLEEEVRRYARWADGLPVRPSRFCNPSEPRQAVAQRFARLAGLPHLTERQVTWVRDKAAMKDRFRELGLRTARYARVACAADVERFAARCGWPLVLKPTDSFACVDTFRLDGPSCLAGTDFGAREWMVEEHLGGTEWEVCALIHDGRVLDAWPSAMPCRPLDIVDGALNANISVATGEGPGVDLRALLQRIATGMGLDHGYVHMEFFLVDGQVHAGEIGVRLAGCEITANHGLAYGFDVFGATLDVYLGRRPPLRYGLRRCAGDLLLPLPGSGVVRAVTPREELLRIPGVVDAVLKVGVGDVVAARRASHNASGYVHVTGTSIGEVERRMREVLDTFTIDVAPAAGAREAGAAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNR0</accession>
    <name>A0A2G1XNR0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_04785</name>
        <name evidence="2" type="ORF">CYQ11_28750</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52884">
        <property type="protein sequence ID" value="PHQ52884"/>
        <property type="gene ID" value="BLA24_04785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11457">
        <property type="protein sequence ID" value="PPT11457"/>
        <property type="gene ID" value="CYQ11_28750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008634">
        <property type="entry name" value="Gas-vesicle_GvpO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05800">
        <property type="entry name" value="GvpO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028743">
        <property type="entry name" value="GvpO_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="98" mass="11069" checksum="9F25DC8E2BE3DB2D" modified="2018-01-31" version="1">MADTPNHSDESAKPLTAPQVLRAAHEQFAELTGRHPEGVSRFERTEDGWVLEAEVVEITRVPETMSVIALYEVTLDSGGLLTGYRRVRRYERGRTDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNS6</accession>
    <name>A0A2G1XNS6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANTAR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Antitermination regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_04510</name>
        <name evidence="7" type="ORF">CYQ11_01770</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52841">
        <property type="protein sequence ID" value="PHQ52841"/>
        <property type="gene ID" value="BLA24_04510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11790">
        <property type="protein sequence ID" value="PPT11790"/>
        <property type="gene ID" value="CYQ11_01770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="5">
        <location>
            <begin position="61"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="528"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="828" mass="88058" checksum="A0DBFDBA52FF26C5" modified="2018-01-31" version="1">MSTREQPSPSDPDDDRPRPGKAAGRPRGGTVPPQSRTGEDGRTADGDGDPPSSVGRLAATVERLRRQVTAAHAAADGRALVELAKGVLVERLKCSPAEAARQLSALAGQAGLSQLELAADIVNEAARDRLTEAACDFVERAASPAREEVSGTSLAVRLRTAESASLAADDTQAVAESLLEHALAPLGATAVAVWTVGPDGSLTLAGHAGFATGEAGRWRYVPPGVATAARQALAERRTVWFPSFPRAGVPSIGHQHTRGGRVVVPAGTGGRIHGVLEICWPHALAPQPPRIERQVEALAELCAHTLETCSPNGTGHATAGSAPPSSLGELVDLADGLYDPALVLLPCVDAEGVLTDFRIYHTNSCFVDPAGRPRSAVEGVLLLEAYPMAAGDSDLFEKVERVHATGEPFRARRMPLTALVDQVPLKAVADVSISRHGGSVLLIWRIEDEMARLASLLQHAQRLGRIGGFEENTVTGDITWNSQLFTLYGLPPAAAPIPLRELAGHAHPDDSVAIGRFLRTLTHHRRPASSSFRLQRPDGVTRHIRVVAEPVLDAEDRLLAVRGAYQDISAQHWTEVALAATRDQLAHTEQQSAERDRLALQLQHAIMPPTRAPIDVPGLQVAVRYRPAESDSLVGGDWYDAVVLPSRQVLLCVGDVAGHGIQAATSMVVLRNALRGLAVTGASPAQLLSWLNTVAHHLTEHVTATAVCGLYDPATRVLRWARAGHLPPVLVRGRQATALPLLGGLLLGAVGEAMCEEGELLLREGDVLLMYTDGLVERRDRSVHESLAHLLTTARVSAPSVEQLLEHVLTHSRADTDDDTCVIGIQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNT1</accession>
    <name>A0A2G1XNT1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_04880</name>
        <name evidence="12" type="ORF">CYQ11_28650</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52897">
        <property type="protein sequence ID" value="PHQ52897"/>
        <property type="gene ID" value="BLA24_04880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11443">
        <property type="protein sequence ID" value="PPT11443"/>
        <property type="gene ID" value="CYQ11_28650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2440"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2531"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2544"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT11443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="2560" mass="270874" checksum="90BD96D8FA520408" modified="2018-01-31" version="1">MGVDGNGTVPDSRLIAVVGAACRLPGGITDLDGLWRALCQGSDLVTDVPADRFDADRFVDPSMPRPGKSYTRAGGFLDDISGFDAAYFGIAPKEAAQMDPQQRLLLELAAEACDNAGIAPAALAGSDTSVFVGISDHSYGALQMLMTESVNAYTMSGAASSIAANRISHFLDLRGPSIAVDTACSSALVALVQACQGLLAGTSAAALVGGVNLLLSPYHYVGFSQASMLSPTGRCRSFSAGADGYVRAEGGGVVLLKRLTDAVADGDRVLGLIVDSAANSDGRTPGLALPRVETQEALLRQVYARAGVDPDDVAYVEAHGTGTPVGDPIECEAVGRALGSRRTNGELPIGSVKSNLGHLEPASGIAGLLKAMLVLRHGVIPPTLHALPPNPNVDFPALRLAPAAESREIVVGERTVAGVNSFGFGGANAHVILAPAPLATATPAPPADAPRLVVVSARTRDALAVVARRTAERLAAADPDEFYDLAYTAGMRRGKHPHRAAVLADGPAEAAARLTALAESLAAPALPDATGSTEGDGAEAAADATPQAPQTPDDHTAPTRDPARGHGTAVADAVARGRIAFAFCGNGAQWAGMGADLLATDSVFREAIDAVDAALSPHTGWSVAEVLAGPPAGLSVSATEIAQPLLFAVQVALVEVLRRQGVEPAAVTGHSVGEIAAAHVAGALTLEQAARVIAARGRSQAATAGTGRMAVVSLPREEAEKAVEAHPGLSVACVNTARDVTVSGPADRLAALRADLTRQGVACTVLDVDYAFHSEAMDPVEEPLRAALEWLRPTPVRIPMLSTVTAATVEGPELDADYWWRNVRRPVLFAPAVQRLLGEGYDVFVDIGPHPVLRPYLRRLTEKCTAPVAVVPTLAKDEDGPAALRTALAALAAAGARLDWGVHFPVRGRVTDLPAYPWQRERHWNGSPGAWAGTFRDGGLDHPLLGDRLPLHEPTWRGPVEPVLVPWLADHRVGGAVVLPATGYAEMALAAGRRVLDGPAEVEHLEITRALVVPWENPAAVNLHLTLSSGDGDLTIASAMGRTGEPTRHAKGRVRRLLRGRPAPVDIPALRERCAGRADPEELYRTLTGAGLDYGPAFRTLRELHVGDGEVLAAYRNDQPADGYEVHPALLDGALQAGVPLMADVLARHRHAYLPGAIDALRVWQTPPQEGLVHLRERFRSQAEVCWDITLTDGAGHVMAEMAGCRLRRFDGLRTSPLIRYGTVMRAAPYASVPAQPSPLPGPSRILAAAQPRIDEVRAAWYGMGYERVRHRLKEGAALALAECLRDLLPEGAESYGPEDITAAGVQPHHLRLCHLFLPLLERYGLAERLEDGRWRPLKEGLHTPDSGRRVARDHPAFGAVIALAAARRPSLLEELLGRSEPLTLLGEGVGELVELFFDVAPHSRFHNRLMQALLSVMVDRWPADRPLRVLEVGGGTGGTAAALLPLLPPERTHYCFTDVVPLFLTRAEKRFSGYDFVDYRTFDLDAGPTEQGLTEGAFDVVVAANALHTAKDLARALRRVAALLAPGGVLLALEEHDAQLTAPFFGTLESFWTFTDHELRPETLLLPAPRWPGLLRRCGFTDVVRTGDGRRGIDAEASVLLAAVPHRPVAAPAPPPADGATAWIVASEDTAGEELRGAVAGALGAAGAGVVREGVAGRTSEQWAELIPPDAGAVAVVLLLDGGAGEPGPHELVDLTTHRLAVLRAFAAVSEKLREGVRVTLWVVTRPSGALPAPERPDFPADAAVWGAARTLGNEHLRLTVRRLSLERTPGDAAGDGRRVARELLTPTDEDEIALTSRGRFVPRLIDVSDTPRGTADSRDVAAFALEVRDPGLAYRLAWKETEPPAQAGPGDVVIGVRAAALNYRDVMQTVGVLPPVDTLPRRARQPGPGMECAGVVEAVGPGVTSVAVGDRVFALAPDAFASHVVTSEHAVGRMPKSMSFTEAATLPVVFLTVHYGLGRLARLAPGETVLVHGGAGGVGLAALQYAHRRGAHVIATAGNRVKRELLRLLGVEHVLDSRDLRFAEEIREITGGRGVDVVLNSLAGEAISRGLEVLRPGGRFVELGKRDILENKPLRLRPFDRNIAFFGVNLTQLLHDPALAMTQFAEVTALVRTGRYRPLLHTVFPAARVAEAFRLLQHSRHIGKVVVAFDPLDEPLVVERAPRPLELDPRGTYLVTGGLGGFGAASVHWLAARGARHVALVGRRGADSPEAPALLSALAAGDVRAHVHAADVCDAAAMRRVVAEAEAEGRPLRGIVHSAMHLDDGFFTDLTDDRVRAVLAPKMGGGAVLDSVARGRPLDLFLAYSSVTATIGHVTQSGYVAGNLYLEALARKRRELGLPALAVAWGAIGETGYVVRNNLLGTMSQMGLRPLTPDAAFEVVEGFLTGEVDVAGAGHYNWELLGRLLLTVGAPRLALLMPVPGTGGALTREEILSKLAGMSPEEAQQYIADSLARVLADVVQIPVEQVDHHRRIDTYGVDSLMATEVLTSLRQQYDVDIPPMELLRSEGTIADIARIIQLRLGLATGTGADTLAPGALPRREEPKALPAGERPEQEEEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNX8</accession>
    <name>A0A2G1XNX8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypE</name>
        <name evidence="4" type="ORF">BLA24_05075</name>
        <name evidence="5" type="ORF">CYQ11_28455</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52926">
        <property type="protein sequence ID" value="PHQ52926"/>
        <property type="gene ID" value="BLA24_05075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11413">
        <property type="protein sequence ID" value="PPT11413"/>
        <property type="gene ID" value="CYQ11_28455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="59"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="180"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="353" mass="35268" checksum="660C08F8016A4F42" modified="2018-01-31" version="1">MADITLDPSAWTCPAPLRDQPVVVLGHGGGGALSAELFDQVFAPAYGNDVLAGLGDSAAVEVGGARLAFTTDSHVVRPLFFPGGSIGDLAVNGTVNDLAMSGARAAYLSCAFILEEGTALSVVSDVARAVGKAAEAAGVTVATGDTKVVDSGHGDGVYVTASGIGLIPHGVDIRPQRAAPGDVVIVSGPVGMHGIAVLSVREGLEFGVEIASDTAPLGGLVAAMLAVTPDLHVLRDPTRGGVAGVLNEIATASGTGVVLTEESVPVPEPVASACGFLGLDPLYVANEGKLLAFVPPEHADAVLAAMRAHPRGAGAAVIGTCVAEHPGTVVARTRLGGTRVVDLPLGEQLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPG6</accession>
    <name>A0A2G1XPG6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01970</name>
        <name evidence="5" type="ORF">CYQ11_04330</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53137">
        <property type="protein sequence ID" value="PHQ53137"/>
        <property type="gene ID" value="BLA24_01970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12227">
        <property type="protein sequence ID" value="PPT12227"/>
        <property type="gene ID" value="CYQ11_04330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="202" mass="21830" checksum="41E9CC0223900208" modified="2018-01-31" version="1">MVFGRSDRRERSAVAPVALKLLVAGGFGVGKTTLVGAISEIKPLRTEELLTEAGRPVDDTSGVEGKRTTTVAMDFGRITLRDDLVLYLFGTPGQDRFWFLWDELAQGALGAVVLADTRRLEDCFAAVDYFERRGIPFTLAVNCFDGAVRYPEEAVRDALDLDPGVPVLLCDARERESVKDVLVSVVEHAMAGGLTGARAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPI7</accession>
    <name>A0A2G1XPI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_03305</name>
        <name evidence="2" type="ORF">CYQ11_16985</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53130">
        <property type="protein sequence ID" value="PHQ53130"/>
        <property type="gene ID" value="BLA24_03305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16616">
        <property type="protein sequence ID" value="PPT16616"/>
        <property type="gene ID" value="CYQ11_16985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="93" mass="9760" checksum="A924A926F53CE377" modified="2018-01-31" version="1">MFCSPGGRTSVTNYPLAPGYQVNVRRGPSTDSELIKVLPQGTSVQIRCQTRGETVSGPCGTTDVWDSIAPGQYVSDAYVKTGTSGFVAVRCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPP6</accession>
    <name>A0A2G1XPP6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_02460</name>
        <name evidence="8" type="ORF">CYQ11_04825</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53217">
        <property type="protein sequence ID" value="PHQ53217"/>
        <property type="gene ID" value="BLA24_02460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12308">
        <property type="protein sequence ID" value="PPT12308"/>
        <property type="gene ID" value="CYQ11_04825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="186"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="396"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="548" mass="57322" checksum="33A0C051C5861249" modified="2018-01-31" version="1">MTPLDAMLTILREEGVDRVFGNPGTTELPFLDALTDAEDIEYVLGVQEASVVAMADGYARATGRPAFVSLHVAAGLANGLVGLLNARRSRTPLVVTAGQQDRRHLVQDPMLSGDLVGLARPAVKHVFDVQHGYDLPVMLRRAFALAVQPPAGPVFLSVPMDLLDEDTPVEVPDRSVLAPQGPATEVAAAARLLAGAERPVIVAGDGVGRDGAVAELVALAEALGAAVYHQPMHDALDFPFTHPLHQGALAPVNAEIRATLSPYDVVLVVGAHAFTPHHYSPGSPVPETATVIQLDPDPGEPGRAFPVSLGLVGAIRPTLAALAGELTGRVTAAGERTDALRRAAELRRALVESEVLAGYGPAPLDPLSAAHAVAAALPDDAVVLEEAITTGLKLREVLRLEAPGSLLHTVGGGLGWGVGGAVGHRLGDPRRPVVAVLGDGCTMFGLQGLWSAARYGVPVTFVVMNNGEYRTLKHTLDDRDSRATRAGHYPGLDLGPPRLDFTRAAAFFGVESVRVTDPRHLSEVVAKAVQGDSPLLIEVPITAHADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPQ4</accession>
    <name>A0A2G1XPQ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_02620</name>
        <name evidence="5" type="ORF">CYQ11_04915</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53227">
        <property type="protein sequence ID" value="PHQ53227"/>
        <property type="gene ID" value="BLA24_02620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12319">
        <property type="protein sequence ID" value="PPT12319"/>
        <property type="gene ID" value="CYQ11_04915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="27797" checksum="EC7C7133C118B298" modified="2018-01-31" version="1">MPSPAEENGLWIRRFTPSPDPRARLVCLPHAGGAASYFFHMSEHLAPSVEVLSVQYPGRQDRHAERCIEDVRELAERVCHALACWGDLPLLLFGQDMGALVGFEVARLLEEKQGVPPLALFAAGCRAPAAGRDEHVHLLDDRGLVAEVQRVNGGDADAAPPPDERLLRRTLPSIRSDYKAFETYRPLPGARVTCPVIALVGDRDPKVSASEANAWRGHTCGAFELQVFPGGHFFLEEHQPQVVNLISDLFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPR8</accession>
    <name>A0A2G1XPR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Benzaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02455</name>
        <name evidence="6" type="ORF">CYQ11_04820</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53216">
        <property type="protein sequence ID" value="PHQ53216"/>
        <property type="gene ID" value="BLA24_02455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12307">
        <property type="protein sequence ID" value="PPT12307"/>
        <property type="gene ID" value="CYQ11_04820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="486" mass="50268" checksum="A79815B1F0BF8325" modified="2018-01-31" version="1">MTRLVDPAGLRGKVYGDGWRTTAAGTADTVEPATGATLATVGLAGAAEVRAAAASAARAQPGWAATPPAERAELMRAAARLLEEHRAEVVEWIVREGGAVVPKAEAEVDAVLDELWVAASLHTQPHGHLLPSVPGRHSVARRLPLGVVGVISPWNFPLLLGMRAVAPALALGNAVVLKPDLHTPVSGGLVVARLFEEAGLPAGVLHVLPGGAEAGAALTESPDTAMIAFTGSTAVGRLIGETAGRALKRVSLELGGNNALIVLDDADPGTAASAGAFGAFFHQGQVCMTAGRHIVLERVADAYVEHLTRRAERLSTGDPWTAKPDLGPLVDAAQRERVERIVRESVAAGARVRTGGTGEGPFYRPTVLTGVTPRMPAFTEEIFGPVAPVVVVPDVETAVAVANDCAYGLTAGVLTGSPERGLAVAERLGTGIVHVNDQTIGDDAVVPFGGRGASGNGSRHGVLHSWDEFTQWQWMTVQGAVPAYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPX4</accession>
    <name>A0A2G1XPX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-(1-2)-phosphatidylinositol mannosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_02925</name>
        <name evidence="5" type="ORF">CYQ11_05220</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53282">
        <property type="protein sequence ID" value="PHQ53282"/>
        <property type="gene ID" value="BLA24_02925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12377">
        <property type="protein sequence ID" value="PPT12377"/>
        <property type="gene ID" value="CYQ11_05220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="386" mass="41243" checksum="977C05552E1CA4CA" modified="2018-01-31" version="1">MRIGIVCPYSWDVPGGVQFHIRDLAEHLIRLGHEVSVLAPADDDTPLPPFVVSAGRAVPVPYNGSVARLNFGFLSAARVRRWLHEGDFDVIHIHEPTSPSLGLLSCWAAQGPIVATFHTSNPRSRAMIAAYPILQPALEKISARIAVSEYARRTLVEHLGGDAVVIPNGVDVGFFAGAEPKPEWQGGTIGFIGRIDEPRKGLPVLMRALPAILAERPGTRLLVAGRGDEKEAVAGLPPEMRASVEFLGMVSDEDKARLLRSVDVYVAPNTGGESFGIILVEAMSAGAPVLASDLDAFAQVLDRGAAGELFANEDADALATAAVRLLGAPERRAELSERGSAHVRRFDWSTVGSDILAVYETVTDGAASVATDERISLRARFGLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPX7</accession>
    <name>A0A2G1XPX7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
            <ecNumber evidence="3 10">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisE</name>
        <name evidence="11" type="ORF">BLA24_02360</name>
        <name evidence="12" type="ORF">CYQ11_04725</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_071963644.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53199">
        <property type="protein sequence ID" value="PHQ53199"/>
        <property type="gene ID" value="BLA24_02360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12291">
        <property type="protein sequence ID" value="PPT12291"/>
        <property type="gene ID" value="CYQ11_04725"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="89" mass="9725" checksum="09C25A19DF711AF3" modified="2018-01-31" version="1">MSKKTFEELFAELQQKASGDPATSRTAELVGKGVHAIGKKVVEEAAEVWMAAEYEGAEATAEEISQLLYHLQVMMVARGISLDDVYAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ33</accession>
    <name>A0A2G1XQ33_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000032">
        <property type="protein sequence ID" value="PHQ53355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53355">
        <property type="protein sequence ID" value="PHQ53355"/>
        <property type="gene ID" value="BLA24_01770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="200" mass="22455" checksum="F60BBA956FF0628C" modified="2018-01-31" version="1">MDFRTELAAFLRSRRARLRPEDVGVRPFSGRRRVPGLRREELAELAGVSVDYYIRLEQGRSQNVSDSVLDAVAGALRLDAAERAHLGHLTRALRDSPAQALAPQPVRAGIQVLLGALDEVPAYVLGRRLDILASNRLARVLFGDFDALPAERRNVAWLHFLDPGARERYPDWEQTARDTVAALRMDLGRYPCDDRLCGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ41</accession>
    <name>A0A2G1XQ41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000032">
        <property type="protein sequence ID" value="PHQ53354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53354">
        <property type="protein sequence ID" value="PHQ53354"/>
        <property type="gene ID" value="BLA24_01750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013841004" evidence="2">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="106" mass="10762" checksum="74C3CA27368C6A34" modified="2018-01-31" version="1">MAYARQAFRARNHSTSRGAAGVGRSAASSSAQKTSSSIWSALSPPYVPRRLITAPVPTTTASAAAWARAGSGAGSRAAAAARVVRSHRTAGYAANGLRAAPARPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQE5</accession>
    <name>A0A2G1XQE5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_00400</name>
        <name evidence="2" type="ORF">CYQ11_07410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53430">
        <property type="protein sequence ID" value="PHQ53430"/>
        <property type="gene ID" value="BLA24_00400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12734">
        <property type="protein sequence ID" value="PPT12734"/>
        <property type="gene ID" value="CYQ11_07410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="291" mass="32456" checksum="C9628555C218B19C" modified="2018-01-31" version="1">MGVPQTVIEHGFPHVETVRSAITALYRRLSYDTVHAFDTSVPPVDVAFSDDEDPYLGVQRVAGSMVRHLRLPDARMIVSFRDMRHAGSVELAAGPEYFIELNARFKTHRRDIGAALSHEVMHVYLHRLGLEFPGTRDNEILTDTAAAYLGAGWLLLDAYRESSVATQKLGYLTPEEFGYVLAKRALAFGEDPAPWFTSPQAYDAYVRGAQWARRDGRRPPLAAAGRLARHRYARDRRAGVAPRGAGYAFESDGASRVSFPCPTCHQRIRVPVRGRVRARCGLCRSVLECDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9K6</accession>
    <name>A0A2G1X9K6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30835</name>
        <name evidence="2" type="ORF">CYQ11_23935</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47901">
        <property type="protein sequence ID" value="PHQ47901"/>
        <property type="gene ID" value="BLA24_30835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15526">
        <property type="protein sequence ID" value="PPT15526"/>
        <property type="gene ID" value="CYQ11_23935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="14222" checksum="19943956A8A50013" modified="2018-01-31" version="1">MSGALILDSEGLAKAVQRDREVHEWLTAARDADLPVITSAAVLVDVIHPRINDAALKWTLSRLRVEPVTQALAQSAADLLRTTALHGHKYAIDAMLCATALAQPGRVTILTSDVEDITILTADHPRVTAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9M0</accession>
    <name>A0A2G1X9M0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30595</name>
        <name evidence="2" type="ORF">CYQ11_23690</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47859">
        <property type="protein sequence ID" value="PHQ47859"/>
        <property type="gene ID" value="BLA24_30595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15484">
        <property type="protein sequence ID" value="PPT15484"/>
        <property type="gene ID" value="CYQ11_23690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046040">
        <property type="entry name" value="DUF5998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19461">
        <property type="entry name" value="DUF5998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="195" mass="20425" checksum="1020BD17C9E6DA7A" modified="2018-01-31" version="1">MAKTGTTTQGLRAAIERSGYYPALVAEAVEAAVGGEPVVSYLVHQETTFDSNEVRRHVTVLVLTSTRFIVSHTDEQAADGTSPSPYATTSTESVKLDRISSVVLSRVVANPEAYTPGTLPREVVLTIGWGAVSRIDLEPAACGDPNCDADHGYTGSSTADDLSLRVSEAGDGPDTVRQALAFAQALSEATVATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9S2</accession>
    <name>A0A2G1X9S2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30945</name>
        <name evidence="3" type="ORF">CYQ11_24045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47919">
        <property type="protein sequence ID" value="PHQ47919"/>
        <property type="gene ID" value="BLA24_30945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15544">
        <property type="protein sequence ID" value="PPT15544"/>
        <property type="gene ID" value="CYQ11_24045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="96" mass="10619" checksum="E8AF0DF3694401D5" modified="2018-01-31" version="1">MANLKGQVSMAKIISYCLEWVRARFAPRIHRRDCRACQTARANRTPAPLPVAPLTPRSPRLADLPMDGGNGPVFLWVTAHGIDIRPRRPHGGEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9T8</accession>
    <name>A0A2G1X9T8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31440</name>
        <name evidence="2" type="ORF">CYQ11_24485</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47975">
        <property type="protein sequence ID" value="PHQ47975"/>
        <property type="gene ID" value="BLA24_31440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15600">
        <property type="protein sequence ID" value="PPT15600"/>
        <property type="gene ID" value="CYQ11_24485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="13262" checksum="13EDFD5C21950160" modified="2018-01-31" version="1">MPFAVEKFEYPDSAKILKEKGITLQRGDGHIVLADCAVSNDIEIRTRVGQKNYCFEVKSRPGDLTLQIPQAFSIAVKDFQVAATIKVDGAESNINVKNGLATFGEAGTPPTGRADLIRLKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Z0</accession>
    <name>A0A2G1X9Z0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="1">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31810</name>
        <name evidence="4" type="ORF">CYQ11_24865</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48040">
        <property type="protein sequence ID" value="PHQ48040"/>
        <property type="gene ID" value="BLA24_31810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15666">
        <property type="protein sequence ID" value="PPT15666"/>
        <property type="gene ID" value="CYQ11_24865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="164" mass="17195" checksum="0F81A799E016CA61" modified="2018-01-31" version="1">MLYTEIDSPLGRLLLTGRPSATAPGGTALVSLSVPEQRNAPAPGPDWRREPAAFGEAARQLAAYFAGETRDFALEFAVEGTEFRRKVWDALDAVPYGATTSYGQLAARIGAPRAAVRAVGGAIGANPLLVLRPCHRVIGADGSLTGYAGGLDRKRHLLALEGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA10</accession>
    <name>A0A2G1XA10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_31885</name>
        <name evidence="7" type="ORF">CYQ11_24940</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48053">
        <property type="protein sequence ID" value="PHQ48053"/>
        <property type="gene ID" value="BLA24_31885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15679">
        <property type="protein sequence ID" value="PPT15679"/>
        <property type="gene ID" value="CYQ11_24940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="118"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="350" mass="37520" checksum="2B0389563E839172" modified="2018-01-31" version="1">MDLKAEPAGDGWRSRVVIMQLVWGHMTSSILSTTTRLGIMDHLGDGERTADEVASLSGTQTEATLRLLRAQAALGLLEEPRPGVFRLTSAGALLRSGRDDSLASLVRLLSDPLMTKPWDHLDACLRTGLPAFDDVYGDDFFTYLKKHPDISAVFNAAMSEGTRTAAEAVAGLYDFNRFRTIVDVGGGDGTLLSYVLRAHPAPRGILYDTAEGLAQAPARLAAEGLTDRCALETGDFFTGAPAGGDLYLLKSIIHDWNDAQCAQILRGVRAVVPADGRVLIVEPVLPERVDPAGAQTSHYLSDLNMLVNVGGRERTRQDFEELCAGAGFAVDSVTSMPAPNPFSLIEVAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF3</accession>
    <name>A0A2G1XAF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BCCT family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Choline transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_32505</name>
        <name evidence="10" type="ORF">CYQ11_25555</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCCT transporter (TC 2.A.15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48149">
        <property type="protein sequence ID" value="PHQ48149"/>
        <property type="gene ID" value="BLA24_32505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15775">
        <property type="protein sequence ID" value="PPT15775"/>
        <property type="gene ID" value="CYQ11_25555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="563" mass="59478" checksum="A517E03A27B3240F" modified="2018-01-31" version="1">MSTESTDVRPPPGDAPDMTLVAVGGLAVLAVVSWAALGKRSFDRVSTTALGWVLSNFAWLFVIAADVFLVLCAVIAVSRFGRIRLGADDARPEFGNLAWIAMMFSAGMGIGLMFYGVGEPLIHFVTPPPGSGVTSGSPAAARTALEYSFFHWTLHPWAIYGMAGLALAYAGFRKGRGNRLSSAFVPLLGEARAAGWPGRVIDLLAVFATVFGTATSLGLGALQVTKGLNITTGVADSKTLELVIIASLSAAFVLSAFSGLHKGVKWLSTLNIVLAACLMVFVFLLGPTVFVLNAIPSATGGYLHDLLVLATRTGAFTDSQWLGAWTIFYWAWWLSWAPFVGTFIARISQGRTIREFLVGVLLVPSGATVIWFCVMGGSALRLDMTGTADMAGTVKEGAEASLFALLDTLPLATLSSWIAMALVMTYFITSADSASLVMGSLSSRGALHPRTWLVVVWGVLMAAVAAVLLVAGGLKSLQSATILVALPFVVVMLALCWSLLAELRTDPGAGPARHHALHGLRDALRTMVGDAMTEQGPVRHPRLRRVAESARDRGEGEEGGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAG8</accession>
    <name>A0A2G1XAG8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SsgA family sporulation/cell division regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32875</name>
        <name evidence="5" type="ORF">CYQ11_25925</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48213">
        <property type="protein sequence ID" value="PHQ48213"/>
        <property type="gene ID" value="BLA24_32875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15840">
        <property type="protein sequence ID" value="PPT15840"/>
        <property type="gene ID" value="CYQ11_25925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14721" checksum="CDE15EE89C4FC567" modified="2018-01-31" version="1">MSTVIEQAVQARIIASAPPSRTVPARLRYDRRDPFAVRIAFPPAASLDGADVEWAFARDLLARGLLRSAGGGDVRVWPCGPHRTVLEFHALEGVAMVQTDTAELRAFLARTYTSVPAGGESGHLDVDSDLAALLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAQ3</accession>
    <name>A0A2G1XAQ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33360</name>
        <name evidence="3" type="ORF">CYQ11_26410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48291">
        <property type="protein sequence ID" value="PHQ48291"/>
        <property type="gene ID" value="BLA24_33360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15922">
        <property type="protein sequence ID" value="PPT15922"/>
        <property type="gene ID" value="CYQ11_26410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="159" mass="18369" checksum="BB5C21673800F81B" modified="2018-01-31" version="1">MSGHTDNSIIIDAPLDLVWDMTNDIENWPQLFSEYASVEVLSRKGDTTTFRLTMHPDADGKVWNWVSERTMDRARLTVNAHRVETGPFARMNIRWEYAELPGGVRMRWVQDFAMKPDAPVDDEWMTDNINRNSRTQMALIRDRIEQAAGERRSASVMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB53</accession>
    <name>A0A2G1XB53_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="11" type="ORF">BLA24_29065</name>
        <name evidence="12" type="ORF">CYQ11_06410</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48431">
        <property type="protein sequence ID" value="PHQ48431"/>
        <property type="gene ID" value="BLA24_29065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12573">
        <property type="protein sequence ID" value="PPT12573"/>
        <property type="gene ID" value="CYQ11_06410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="10">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="22"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="244" mass="25133" checksum="8B2216E3BF84A3D2" modified="2018-01-31" version="1">MSDTVETAARTAPAAVIVGIDGPSGTGKSSTSKAVAAKLGLRYLDTGAQYRAITWWMLSNGIDVDDATAVAEAAGKPEIVSGTDPSAPTIVVDGADAAGPIRTQEVTSAVSAVSAVPEIRTRLTELQRAIAAEAPHGIVVEGRDIGTTVLPDADVKIFLTASPEARAARRSGELKGKEATDLAATQAALVKRDAADSGRKTSPLAKADDAVEVDTTELTLDQVIECVVTLVEEKRSAAEEKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB61</accession>
    <name>A0A2G1XB61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IucA/IucC family siderophore biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29225</name>
        <name evidence="5" type="ORF">CYQ11_06250</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48452">
        <property type="protein sequence ID" value="PHQ48452"/>
        <property type="gene ID" value="BLA24_29225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12552">
        <property type="protein sequence ID" value="PPT12552"/>
        <property type="gene ID" value="CYQ11_06250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="2">
        <location>
            <begin position="160"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="3">
        <location>
            <begin position="403"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="591" mass="63689" checksum="8D3CD289E4B3246D" modified="2018-01-31" version="1">MSTAATARTANAAEAANDAAENDLLGRVLSTLLRENAYGLRSRAATERRPDGDWLRLPAGKETLLLPVGPEGFQCEVQAREPVLHTPGGPVSGLRPVLTRLRAAAPDEDRAGFDAFLAECEEALAAARLHGLVRDAVVDRLSRTYGHSTAGWTGLRGALAFDTLAAFRDHPVYPTGRARSGLGERQLRAYAPEFHPVFALRWLALPAGAVHGERGELPHWWPTPTTLGLPRRLDATHLALPVHPLTADGPLPGALRAAGLADHAHLAPKPWLEVTPTLSTRTVAVADDPETHLKLPLATATLGLRNRRTIKPGALVDGETGQRLLEEIVAREPRFAGTVLLADERTHLRAGHELLVTLLRRYPAGLDDAHVVPVAALLARAPDGRLVADALAERYYGGSLVAFVDAYLTLLLDWHTTLFSYGIALESHQQNTSVVLDERDGRPRLRLLLKDNDGPRVHSVRLAARLGGAAADLLGFDDRRILVAGDGPVADVFATITVHLCAGALAFELGRLGRGPLEGWLRQLRDRLAEATDRLAPGTAAVLRARVLDADRLPVKAMITAGTLLTKERSGAADINKYYVEGPNYLRPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBD5</accession>
    <name>A0A2G1XBD5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">BLA24_29870</name>
        <name evidence="9" type="ORF">CYQ11_05600</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030493496.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48557">
        <property type="protein sequence ID" value="PHQ48557"/>
        <property type="gene ID" value="BLA24_29870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12441">
        <property type="protein sequence ID" value="PPT12441"/>
        <property type="gene ID" value="CYQ11_05600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="128" mass="14513" checksum="E5DF9747216261EE" modified="2018-01-31" version="1">MARVKRAVNAHKKRRAILEQASGYRGQRSRLYRKAKEQVTHSLVYNYNDRKKRKGDFRQLWIQRINAAARQNGMTYNRLIQGLKAANIEVDRKILAELAVNDINAFAALVEVAQKALPADVNAPKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBD6</accession>
    <name>A0A2G1XBD6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29790</name>
        <name evidence="4" type="ORF">CYQ11_05685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48543">
        <property type="protein sequence ID" value="PHQ48543"/>
        <property type="gene ID" value="BLA24_29790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12456">
        <property type="protein sequence ID" value="PPT12456"/>
        <property type="gene ID" value="CYQ11_05685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="31679" checksum="66E72B6A8061DA35" modified="2018-01-31" version="1">MSAREQPPSPLAHRVPDLGSLELLLAVARLGSLGRAARELGITQPAASGRVRSMERLLGVALVERSPRGSQLTPSGVLVTDWARRVVEAAEAFDAGAQALRTRRDSRLRVAASMTIAEYLLPGWLVALRTLRPGLAVSLLAGNSAAVAERLLSGEADLGFVEGLDVPSGLDGTVIGHDRLVVVTAPGHPWARRRGPLEVAELAAAPLILRERGSGTRQVLDAALAGSGGPAAPLLELASTTAAKAAVVGGAGPSVLSELAIGEELAARRLVEIPVAGLSLRRALRAVWPTGHRPAGPARDLLGLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH4</accession>
    <name>A0A2G1XBH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29835</name>
        <name evidence="3" type="ORF">CYQ11_05640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48551">
        <property type="protein sequence ID" value="PHQ48551"/>
        <property type="gene ID" value="BLA24_29835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12448">
        <property type="protein sequence ID" value="PPT12448"/>
        <property type="gene ID" value="CYQ11_05640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="29453" checksum="F263EE70CD41097C" modified="2018-01-31" version="1">MSTEADAVPRRPAPVHVPPMPSSPPAVSGPPAVSGVPAAPGRNVAAAVCTILGVGLIAGAAAGSWVTGGPHDRTTAQAAYERGATLWQTLPVDELFPVAVHGGAAGPGGADRDWTRTGVAPAEGCTGAFDPLLAKALAPVGCKRLLRATYTDATSTSVTTVGLLVTDADPSGMRALRKRFADENLDERTDLMPRPYAPRGTAAARFGDAQRASWRIDVLTDTPAVVYSVTGFADGRAGVPPQPAVRATAPGAATTAAQAGLGHDATALAERVARGYRDATHRTAREDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBN4</accession>
    <name>A0A2G1XBN4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="20" type="ORF">BLA24_28280</name>
        <name evidence="21" type="ORF">CYQ11_07190</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48620">
        <property type="protein sequence ID" value="PHQ48620"/>
        <property type="gene ID" value="BLA24_28280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12700">
        <property type="protein sequence ID" value="PPT12700"/>
        <property type="gene ID" value="CYQ11_07190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="35"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="438"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="670"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="666"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PHQ48620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PPT12700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="715" mass="80341" checksum="796E92C01216A625" modified="2018-01-31" version="1">MRPVSKIERKVAPFEVVSSFQPSGDQPTAIAELERRIRAGEKDVVLLGATGTGKSATTAWMIEKLQRPTLVMAPNKTLAAQLANEFRELLPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDSSINEEVERLRHSATNSLLTRRDVVVVASVSCIYGLGTPQEYVDRMVPLKVGQEIDRDQLLRRFVEIQYTRNDLAFTRGTFRVRGDTIEIFPVYEELAVRIEMFGDEIEALSTLHPLTGEVISDDQELYVFPASHYIAGAERMEKAIAGIEAELEQTLARMEKQGKLLEAQRLRMRTTYDIEMMRQIGSCSGIENYSLHMDDREPGSPPNTLLDYFPEDFLLVIDESHVTVPQIGAMYEGDASRKRTLVEHGFRLPSAMDNRPLKWEEFTERIGQTVYLSATPGKYELSRGDGFVEQIIRPTGLVDPEVVVKPTEGQIDDLVHEIRTRTERDERVLVTTLTKKMAEDLTDYFLELGIQVRYLHSDVDTLRRVELLRELRAGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGTSLIQTIGRAARNVSGQVHMYADKITPAMEKAIEETNRRREKQIAYNKERGIDPQPLRKKIGDIVATLAREELDTQELLGTGYRKGDKDKAKAPVPTVASAAGGKGKAAQGKAKAAKGAVTPTDRPAAELAQLIEDMTDRMRAAAAELQFEVAARLRDEVGELKKELRQMREAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBT4</accession>
    <name>A0A2G1XBT4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_28845</name>
        <name evidence="8" type="ORF">CYQ11_06620</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48714">
        <property type="protein sequence ID" value="PHQ48714"/>
        <property type="gene ID" value="BLA24_28845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12605">
        <property type="protein sequence ID" value="PPT12605"/>
        <property type="gene ID" value="CYQ11_06620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ChpA-H"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304879" evidence="5">
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            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="104" mass="10258" checksum="701579C0BCCF4006" modified="2018-01-31" version="1">MNSAKKAALALAAAGVALGASVIPAAATDDDGFGGALASGVAKGSPGVISGNVIQVPIDIPINICGNTIDIVGLLNPTFGNTCVNDGHEKHHDHHEGGRHGGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBV7</accession>
    <name>A0A2G1XBV7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CYQ11_06705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="PPT12621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48698">
        <property type="protein sequence ID" value="PHQ48698"/>
        <property type="gene ID" value="BLA24_28760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12621">
        <property type="protein sequence ID" value="PPT12621"/>
        <property type="gene ID" value="CYQ11_06705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="66" mass="6717" checksum="E738AA8D8AEEA3CB" modified="2018-01-31" version="1">MSAAPTSPAPSPGRRPFGIVRLTAPVPAVPTDRAPAAVPAPARWHGPGVPLPPLSIAALRSPRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY8</accession>
    <name>A0A2G1XBY8_STRCJ</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CYQ11_18420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48774">
        <property type="protein sequence ID" value="PHQ48774"/>
        <property type="gene ID" value="BLA24_27235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14578">
        <property type="protein sequence ID" value="PPT14578"/>
        <property type="gene ID" value="CYQ11_18420"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF6350"/>
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        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
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            <end position="185"/>
        </location>
    </feature>
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            <end position="241"/>
        </location>
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            <end position="280"/>
        </location>
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            <end position="346"/>
        </location>
    </feature>
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            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
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            <begin position="457"/>
            <end position="525"/>
        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="647" mass="66017" checksum="A1D93C410B56AEF1" modified="2018-01-31" version="1">MSHYAEHGPASPPRHRPAVRGPSAASHVFFGGVLAAGLGLGAFAMGVLALWITSPYPDSGPADALRIAADLWLLAHGAALVRTDTLSGVPAPLGLTPLLFAVVPCTLLYRAARHALEPAESAPPDTPGPAPRTAITAMLGGYLLVAAAAALYSWSAPVRVAPLSALLHLPLVAAAFIAAGVWTAAGLPAPPAPLFVRRYVPWGVRAWFTRSHMATVVRAGVSATGVLLLGGTLLLAVSLGLHTGAARDAFAHLATGWHGRLAVSLLSAALLPNAVVWAAAYGVGPGFTAGAGGVVAPLAVAADRPLLPHFPLLAALPSPGEAGPLGLAGAVALTAGVGVAAARAAVPRRTTRVGRREVAMIALLAALLCGVLTTVLAYAASGALGNAVLADFGPPCWRTGAAAAAWTGALGVPGALVVRWRRGAVLRARAKAGTDADAGVLTGWRRVGYALGLAVDADEPGQEPQPQPASPAPPHDPEAQRHPREPRHPEEPGATGTQGNENEDAGEDAGEDEAGREAGGDDERPRSWWRGVAAWYGFGPSEPPPPEVAYEPEMLPLLPTLGAGQPPEAAPPAPARHPWWKPRRKDPEAQEPGPRDPGAPDPAAVSAPAWHDTGSRQVRWAALKDSGARLAPELDAPGAKPSAPEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC19</accession>
    <name>A0A2G1XC19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine/betaine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27145</name>
        <name evidence="5" type="ORF">CYQ11_18510</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48758">
        <property type="protein sequence ID" value="PHQ48758"/>
        <property type="gene ID" value="BLA24_27145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14594">
        <property type="protein sequence ID" value="PPT14594"/>
        <property type="gene ID" value="CYQ11_18510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758460" evidence="2">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="42"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="324" mass="36200" checksum="781E8105D4CB49FF" modified="2018-01-31" version="1">MTRKVKAAVLAAAVGLMATATGCGAADMTKQSSPYANAAGAKTVTLSVQSWVGARANTAVAQYLLEHELDYRVDTVQVDEVPAWDALSQGRVDAMLEDWGHPEQEKRYVQDKKTVTDGGDLGVTGHIGWWVPTYFAEAHPDVLDWRNLDKYASQLRTSESGGKGQLLDGSPSYVTNDKALVKNLKLDYQVVFAGSEAAQITQIKQFAKDKRPFLTYWYEPQWLFNQVPMTEVKLPAYTDECAEKGTADPSTVDCAYPTTPLKKYLNTEFTKKGGKAARFLKKFHWTKEDQNEVAQMIAEDKLPADEAAKRWVQRHPDVWKTWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC31</accession>
    <name>A0A2G1XC31_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1446 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27540</name>
        <name evidence="2" type="ORF">CYQ11_18105</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48824">
        <property type="protein sequence ID" value="PHQ48824"/>
        <property type="gene ID" value="BLA24_27540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14530">
        <property type="protein sequence ID" value="PPT14530"/>
        <property type="gene ID" value="CYQ11_18105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="563" mass="59338" checksum="E73EB3D46B19560C" modified="2018-01-31" version="1">MPVPLLRIGNASGFYGDRFDALREMLTGGPLDVLTGDYLAELTMLILGRDRLKDPGRGYARTFLGQLEEGLGLATDRGVKIVTNAGGLNPAGLAERITELADRLGIRARVAHVTGDDLIGEGTWAPGTLTANAYLGGAGIAECLRAGADVVVTGRVTDAALVSGPAAAHFGWRADDLDPLAGAVVAGHVLECGTQATGGNYAFFGEHDVRHPGFPIAEIHPDGSAVITKHPGTGGAVTVSTVTAQLLYETAGARYLGPDVTARLDSVRLTPDGPDRVRISGVRGEAPPATLKVGLTRPGGWRHEVVFVLTGLDVEAKARLVRAQLDGVLATHRPAEVRWTLARTDRADAPVQEEASALLRLVVRDRDPEVGRAVNAACVELALASYPGFHVTAAPGKGTQYGVFEAAYVDADAVRHVAVLPCGNRVPVLPAPPVRGTAAPPPRPVLPEPLPAGPVRSAPLGLVAGARSGDKGGDANVGVWVRDDDAWRWLAHALTVDRFRQLLPETVGYRVERHVLPNLRALNFVVDGLLGEGVASQSRFDPQAKAVGEWLRARHLEIPEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC75</accession>
    <name>A0A2G1XC75_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27780</name>
        <name evidence="3" type="ORF">CYQ11_17860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48864">
        <property type="protein sequence ID" value="PHQ48864"/>
        <property type="gene ID" value="BLA24_27780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14489">
        <property type="protein sequence ID" value="PPT14489"/>
        <property type="gene ID" value="CYQ11_17860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="31455" checksum="BD7D6428AD649F9F" modified="2018-01-31" version="1">MSVSGSSSAQQARQVLADRLRELVKDAGLDGKDLAALCGWHPSKVSRISTAKTQPSADDIRAWCRACGAEDQADDLIASLRAVEGTWLSWRRLERAGLRRSQVERLPLYQRTRRFRSYCSWALPGLLQTYQYTEDVLRVIQQQRVPVDDVADAVAARMERQRVLHEGQRLFAFVIEEPVLRNTLSSGEAQGAQLEHLLSVSRLPNVSLGVIPVAQQRRQLPVENFWIYDNAQVNVELVSGYLTITQPSEVSTYAETFATLADMAAYGQKARRMIAAAIADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCC0</accession>
    <name>A0A2G1XCC0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27975</name>
        <name evidence="7" type="ORF">CYQ11_17665</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48897">
        <property type="protein sequence ID" value="PHQ48897"/>
        <property type="gene ID" value="BLA24_27975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14454">
        <property type="protein sequence ID" value="PPT14454"/>
        <property type="gene ID" value="CYQ11_17665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="11"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="309" mass="32012" checksum="E92C8332A3DDCE8E" modified="2018-01-31" version="1">MILTVTLNTALDLTYRVPRLLPHTSHRVTRVLERPGGKGLNVARVLAALGHETVVTGFAGGTTGETVRRLLSECAPADGTLGDQLLEITGATRRTVAVVDAGTGDTTQLNEAGPHVSPHEWAAFGERYARLLDDASAVALCGSLPPGVPVGAYAHLVREARARRVPVLLDTSGEPLRRGIAARPDVVKPNAAELAALTGSTDPLRAAQDARRRGAHAVAASLGTDGMLALTPQGTWRAAPPKPLPGNPTGAGDAAVAGLLSALAEGLPWPDRLTRAVALATAAVRAPAAGEYDPVLYEESLPRVRVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG9</accession>
    <name>A0A2G1XCG9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">BLA24_22875</name>
        <name evidence="13" type="ORF">CYQ11_23200</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48954">
        <property type="protein sequence ID" value="PHQ48954"/>
        <property type="gene ID" value="BLA24_22875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15401">
        <property type="protein sequence ID" value="PPT15401"/>
        <property type="gene ID" value="CYQ11_23200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="111"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ48954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT15401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="250" mass="26112" checksum="C818EE5980161BFD" modified="2018-01-31" version="1">MSKLRVAVIGAKGRIGSEAVRAVEAADDMELVAALGRGDSLDALTEAGAQVAVELTHPDSVMDNLDFCVRNGIHGVVGTTGWTVDRLAQLESWLAASPSTGVLIAPNFSIGAVLTMAFAQQAARFFESVEVVELHHPNKADAPSGTATRTAQLIAAARREAGCAPQPDATTTALEGARGADVDGVPVHAVRLRGLLAHQEVLFGDTGETLTIRHDSLHHSCFMPGILLGARRVVSAPGLTFGLEHFLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCU8</accession>
    <name>A0A2G1XCU8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsB</name>
        <name evidence="7" type="ORF">BLA24_23235</name>
        <name evidence="8" type="ORF">CYQ11_22840</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49015">
        <property type="protein sequence ID" value="PHQ49015"/>
        <property type="gene ID" value="BLA24_23235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15340">
        <property type="protein sequence ID" value="PPT15340"/>
        <property type="gene ID" value="CYQ11_22840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="287" mass="31703" checksum="8F7A65F7C4111683" modified="2018-01-31" version="1">MAVVTMRELLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLLQSLSYIDRAYEFVKETVAHGGSIMFVGTKKQAQEAIAEQATRVGMPYVNQRWLGGMLTNFSTVYKRLQRLKELELIDFEDVAASGLTKKELLVLSREKAKLEKTLGGIREMQKVPSAVWIVDTKKEHIAVGEARKLRIPVVAILDTNCDPDEVDYKIPGNDDAIRSVTLLTRVIADAVAEGLIARSGGAGEGKGEKAAGEPLAEWERDLLEGEKKADEKPAEAAAEAPAEAEAEKPAADAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ0</accession>
    <name>A0A2G1XCZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">GGDEF-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_23790</name>
        <name evidence="6" type="ORF">CYQ11_22280</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49106">
        <property type="protein sequence ID" value="PHQ49106"/>
        <property type="gene ID" value="BLA24_23790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15247">
        <property type="protein sequence ID" value="PPT15247"/>
        <property type="gene ID" value="CYQ11_22280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="280"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="421"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="705" mass="75289" checksum="5A63208602719EF2" modified="2018-01-31" version="1">MKPTDSAEPASRLRRLSPPALPTVCVALAVLALAAGTFRAVGTGRALFPGQAAGWALATLTALIVAHLVALGRDRWWGGTGSGAALTLAVLLLYGWLPSVLISIAVVALVATARRHRWRQALLHGAVDILGIAAAGLALAGWGIHASVENPWLPDTWRLSAAPKIALAAFLYLAVTRALLWYSVAPRAALTSIARTALMRQALVGGALLGIAPLIAVVADHAPLLLPLFAVPLVALDSTLWIARARAEEQLRDPLTGLPNRQWLLERTWTALDEAEQAGVRAALVLIDLDRFRSVNDTLGHLAGDRLLLQIAERLRLALPRDAEAARLGGDEFAVLLPVADSLTSAQRVARALVADLGSPLDLDGLTLVLEASAGVAVYPDHALDAEGLLRRADVAMYQAKRDRSGVEVYEARRDGNTPDRLGLLGDLRRALDAGEVELHYQPKVAFDGHVEGLEALVRWVHPERGRVSPDEFIAIAESSGLMPRLTEYVLETALCQVAKWRAMGLEVPVAVNVSPRDVHTPGFAGSVAARLARHGVPAGALQLEITEHVLLEDPQRAADTLAGLTGHGVKMSLDDFGTGYSSLVHLRRLPVSELKIDRSFVARLAIDNEDAEIVRCTLDLAHSLGLVVVAEGVEDDETWERLRDLGCDAVQGWLVAAAMPPDETTAWLRLRESGWHREGPPVPVAPAPAAAPAPATEEADQPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ3</accession>
    <name>A0A2G1XCZ3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="5" type="ORF">BLA24_23320</name>
        <name evidence="6" type="ORF">CYQ11_22755</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49029">
        <property type="protein sequence ID" value="PHQ49029"/>
        <property type="gene ID" value="BLA24_23320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15325">
        <property type="protein sequence ID" value="PPT15325"/>
        <property type="gene ID" value="CYQ11_22755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="145" mass="15857" checksum="8DD729B921150A9D" modified="2018-01-31" version="1">MAVKIKLKRLGKIRSPHYRIVVADSRTRRDGRAIEEIGLYHPVQNPSRIEVNSERAQYWLSVGAQPTEPVLAILKVTGDWQKFKGLPAPAPMLVAEPKKDHSGLFDAVVSAADESKGEAITPKAKKSEKKDEAAEAAESAESTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ4</accession>
    <name>A0A2G1XCZ4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">BLA24_23485</name>
        <name evidence="12" type="ORF">CYQ11_22585</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49055">
        <property type="protein sequence ID" value="PHQ49055"/>
        <property type="gene ID" value="BLA24_23485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15299">
        <property type="protein sequence ID" value="PPT15299"/>
        <property type="gene ID" value="CYQ11_22585"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="162"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="382" mass="41280" checksum="1F50D3D1652AC17C" modified="2018-01-31" version="1">MSSETSPQSPARKPRVAVVFGGRSSEHAISVVTAGAVLRAIDRSTYDVLPIGITTDGRWALAADDPERMTISDRALPSVEQLTDSADGGVLLPVTPASREVVYTEPGAVPKALGEVDVVFPVLHGPYGEDGTLQGMLELAGIPYVGAGVLASAVGQDKEYMKRVFLSFGLPVGPYEVIRPREWDTDPTAARKKITDFAGEHGWPLFVKPARAGSSMGITKVDDEAALDEAIAEARRHDPKILVESLLRGREIECGVLEFEDGPRASVPAEIPPVSAHDFYDFEAKYIDSASGIVPAPLSEDETRRVQELAVRAFEAASCEGLVRADFFLTEDGEFVINEINTMPGFTPISMYPLMWEKSGVSYPELVDLLIQAALRRPTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ8</accession>
    <name>A0A2G1XCZ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_23715</name>
        <name evidence="6" type="ORF">CYQ11_22360</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49092">
        <property type="protein sequence ID" value="PHQ49092"/>
        <property type="gene ID" value="BLA24_23715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15262">
        <property type="protein sequence ID" value="PPT15262"/>
        <property type="gene ID" value="CYQ11_22360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="30330" checksum="DD85C8AE0149E478" modified="2018-01-31" version="1">MGALGRAARPPYLRIAAELRDRIASGELRPGDRIPSTRGITREWGVAMATASKALAVLRQEGLVRAVPGVGTVVDAPGTESGAVRTRASRRGGRRRTAGPPLTRERVVRTAVAVADAHGSAALSMRAVATALGVSTTVLYRHVSAKDELVELMADAVFGDVALPAPAPADWRGRLEAWAWAQWALYRRHPWLVKALSFTRSPLPGNVSALMEWSVAPARDRGVDAGRARYAAVTVAGYVRGLAMGMEDEAPAGRDGRAAGFALDALFAFGLARMLDGLGTVAWYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD70</accession>
    <name>A0A2G1XD70_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="5" type="ORF">BLA24_23980</name>
        <name evidence="6" type="ORF">CYQ11_22090</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49135">
        <property type="protein sequence ID" value="PHQ49135"/>
        <property type="gene ID" value="BLA24_23980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15216">
        <property type="protein sequence ID" value="PPT15216"/>
        <property type="gene ID" value="CYQ11_22090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="196"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="523"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="664" mass="73754" checksum="5E04AAEE2B0BB772" modified="2018-01-31" version="1">MIGRIPVLDLGPLVDCGRRPVKAVVGEAFEVTATVFREGHDAVGANVVLRGPSGQAGPWIPMRELAPGTDRWGAEVVPDAEGRWSFTVEAWGDPVATWRAHARIKIPAGIDTELVLEEGARLFERAAAGVPKSDGREAVLDAADALRDTARHPDDRLEAALVPEVTAALTDHPLRELVSSSRPVPVLVERERALYGSWYELFPRSEGARLREGRRPVSGTFRTAAQRLPGVAAMGFDVVYLPPVHPIGTAYRKGPNNALTAGSFDVGSPWAIGSADGGHDAVHPDLGTLDDFDHFVARARELRMEVALDFALQCSPDHPWVAEHPEWFHHRADGSIAHAENPPKKYQDIYPLAFDADFDGLVAETLRVLRFWMDHGVRIFRVDNPHTKPVMFWERVIAEIGRTDPDVVFLAEAFTRPAMMRTLGAIGFQQSYTYFTWRNSKQEITEYLTELSRETAACMRPNLFVNTPDILHAYLQDGGRAAFEVRAVLAATLSPSWGVYAGYELCENTPVRPGSEEYLDSEKYQLRPRDWESAEREGRSLAPLITVLNRLRRRQPALRRLRNLRFHDADNDSVIAYSKRSGSSCVLTVVNLDPHHTQEATVSLNMPALGLGWHESVPVRDELTGETYHWGRDNYVRLEPGRSLAPAHVFSLRPSSQIGGSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD96</accession>
    <name>A0A2G1XD96_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24200</name>
        <name evidence="3" type="ORF">CYQ11_21875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49171">
        <property type="protein sequence ID" value="PHQ49171"/>
        <property type="gene ID" value="BLA24_24200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15179">
        <property type="protein sequence ID" value="PPT15179"/>
        <property type="gene ID" value="CYQ11_21875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046198">
        <property type="entry name" value="DUF6230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19741">
        <property type="entry name" value="DUF6230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304587" evidence="1">
        <location>
            <begin position="39"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="209" mass="21474" checksum="96589DF6AEE80E51" modified="2018-01-31" version="1">MKSQTRGGTRWRRFAVVMVPSVAATAAIGVALAQGALAASFSVSGQQFQVTAKRLHGKGFVQYGANDVTKNGNKPVAVVGINEAEITNLCQAVTIPTPFGDVSMKLTAGEGGKQVEATKLFIDADDLSANATFTNVDIGVAVDATNKGPGPATPGKDGRGAYVPGSFAQQADEVEFTDVNQRAWATSAGTFTLPGLHMGVSMGAAKCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC2</accession>
    <name>A0A2G1XDC2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BLA24_24495</name>
        <name evidence="21" type="ORF">CYQ11_21575</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49228">
        <property type="protein sequence ID" value="PHQ49228"/>
        <property type="gene ID" value="BLA24_24495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15121">
        <property type="protein sequence ID" value="PPT15121"/>
        <property type="gene ID" value="CYQ11_21575"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="353"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PHQ49228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PPT15121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="430" mass="44549" checksum="E75FCF363B238BC7" modified="2018-01-31" version="1">MMRTRPLKVALLGCGVVGSEVARIMTTHTDDLAQRVGAPVELAGIAVRRPDRVRAGVPADLITTDATALVKRGDIDVVVEVIGGIEPARGLITTAFEHGASVVSANKALLAQDGAALHAAAERHGADLYYEAAVAGAIPLVRPLRESLAGDKVNRVLGIVNGTTNFILDKMDSSGAGYSEALDEATALGYAEADPTADVEGFDAAAKAAILAGIAFHTRVRLDDVYREGMTEVTAADFASAKQMGCTIKLLAICERAGDGRSVTARVHPAMIPLSHPLASVREAYNAVFVEAEAAGQLMFYGPGAGGSPTASAVLGDLVAVCRNKLAEATGPGESAYTRLPVSPMDTVVTRYHISLDVADKPGVLAQVATVFAEHAVSIDTVRQQGKAGEASLVVVTHRAADAALSATVDALRKLDTVRGVASIMRVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDF0</accession>
    <name>A0A2G1XDF0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="5">RF MTase</shortName>
            <ecNumber evidence="5">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">prmC</name>
        <name evidence="9" type="ORF">BLA24_24460</name>
        <name evidence="10" type="ORF">CYQ11_21610</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49221">
        <property type="protein sequence ID" value="PHQ49221"/>
        <property type="gene ID" value="BLA24_24460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15128">
        <property type="protein sequence ID" value="PPT15128"/>
        <property type="gene ID" value="CYQ11_21610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="7">
        <location>
            <begin position="115"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="281" mass="30836" checksum="628051AA0666B6CD" modified="2018-01-31" version="1">MNLLLAEVAQATQRLADAGVPSPRFDAEELAAFVHGVKRGELHTVADADFDARYWEAVARREAREPLQHITGRAFFRYLELQVGPGVFVPRPETESVVGWAIDAVRAMDVVEPLIVDLCTGSGAIALALAQEVPRSRVHAVELDETAFGWASKNVEGSRVRLHHGDALAALPELDGQVDLVISNPPYIPLTEWEHVAPEARDHDPELALFSGEDGLDTIRGLERTAHRLLRPGGVVVIEHADTQGGQVPWIFTEERGWADAADHPDLNNRPRFATARKAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDL7</accession>
    <name>A0A2G1XDL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25105</name>
        <name evidence="2" type="ORF">CYQ11_20965</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49333">
        <property type="protein sequence ID" value="PHQ49333"/>
        <property type="gene ID" value="BLA24_25105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15019">
        <property type="protein sequence ID" value="PPT15019"/>
        <property type="gene ID" value="CYQ11_20965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="96" mass="9967" checksum="4CD03518B9861297" modified="2018-01-31" version="1">MISFIASNKMTDRQVGSASMLGFSAAAFQGTGLPGAMSSFLEERPTKASAVKAAAVAQAKPYALAAATNGAGSLNAQHQLHTTWAFRGLEPWRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDS0</accession>
    <name>A0A2G1XDS0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_25350</name>
        <name evidence="6" type="ORF">CYQ11_20725</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49376">
        <property type="protein sequence ID" value="PHQ49376"/>
        <property type="gene ID" value="BLA24_25350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14975">
        <property type="protein sequence ID" value="PPT14975"/>
        <property type="gene ID" value="CYQ11_20725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="474"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="568" mass="55829" checksum="3398959348EB136A" modified="2018-01-31" version="1">MDEGKARAAGDPGTSGAVPHPAAGSADGSPEPAAPGLPAEPRREAPAPAAPGTSPAPEPAPVPLHAPDPYGTPPYGRPGPWAPAPPVQRPVVTPPHGTHVPPTPPPYAASQAEVQPGVTPAQGTALPAYPQPQSGVCDPSVPAAPLPYACAQPGVTPAQGTALPAEAHAPAAAPAGPWQYDPWAAGTRVPESGEATGGGKGGPTRRRIVTGAVAVALVAGAVGGGIGAALERDGGMTPQVRLPQSAADKGDRAPGSIAGIAARALPGVVTIHVSGGGEQGTGTGFVLDKQGHILTNNHVVQPAGSGGSISVTFNGGQTAKATLVGRDGGYDLAVIKVTGVSGLTPLALGNSDSVRVGDSVVAIGAPFDLAGTVTTGIISAKERPITAGGKKQDGSDVSYVDALQTDAPINPGNSGGPLMDSEARVIGINSAIRSAGESEGGGQGGSIGLGFAIPVNQAKRVAEELINTGRATHPVIGVSLDMGYTGDGARVNADGAKGAGVTSGGPADKAGIRPQDVIKKVDGVPVHSGRELIVKVRSHRPGDGLELTVERDGREQSVRLTLGSASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDT3</accession>
    <name>A0A2G1XDT3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_25420</name>
        <name evidence="10" type="ORF">CYQ11_20655</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49388">
        <property type="protein sequence ID" value="PHQ49388"/>
        <property type="gene ID" value="BLA24_25420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14962">
        <property type="protein sequence ID" value="PPT14962"/>
        <property type="gene ID" value="CYQ11_20655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="109" mass="12180" checksum="159468CC036D4FB8" modified="2018-01-31" version="1">MTYVIAEPCVDVKDKACIEECPVDCIYEGQRSLYIHPDECVDCGACEPVCPVEAIFYEDDTPEEWKDYYKANVEFFDELGSPGGASKLGLIERDHPFVAGLPPMNDGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE49</accession>
    <name>A0A2G1XE49_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25875</name>
        <name evidence="4" type="ORF">CYQ11_20195</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49471">
        <property type="protein sequence ID" value="PHQ49471"/>
        <property type="gene ID" value="BLA24_25875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14879">
        <property type="protein sequence ID" value="PPT14879"/>
        <property type="gene ID" value="CYQ11_20195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="17809" checksum="3D54B44A3E3531E8" modified="2018-01-31" version="1">MTEETSTQAEATTPEQEQTSAADQPVSTETAEPSGEDALPEWARKELAKVRGEAANYRTRLRDAESKLGEAKDPAEIEAAVAELKAQNAELERSILRSSVARRHELPDDLADALRGEDEAALEAHAKVLAKYVPAPLPPSLGGGLTPDDGDGEMDPRKLARLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL6</accession>
    <name>A0A2G1XEL6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26875</name>
        <name evidence="4" type="ORF">CYQ11_18760</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49641">
        <property type="protein sequence ID" value="PHQ49641"/>
        <property type="gene ID" value="BLA24_26875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14637">
        <property type="protein sequence ID" value="PPT14637"/>
        <property type="gene ID" value="CYQ11_18760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304912" evidence="1">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="87" mass="9085" checksum="F0C37F4D84460791" modified="2018-01-31" version="1">MAGLLVAATLGGAALAAPAYADDVYGHCTGEGVRIRAAASTSSSVVGLCYSNHRLAHRDVSGDGQWDKVYDVNTGVSGWISHGYWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF00</accession>
    <name>A0A2G1XF00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage head-tail adapter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25890</name>
        <name evidence="2" type="ORF">CYQ11_20180</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49739">
        <property type="protein sequence ID" value="PHQ49739"/>
        <property type="gene ID" value="BLA24_25890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16687">
        <property type="protein sequence ID" value="PPT16687"/>
        <property type="gene ID" value="CYQ11_20180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="111" mass="12833" checksum="FF5AC57A64A749EB" modified="2018-01-31" version="1">MSIQRRRGQKARVWRTVEVTDSRGNTVTMADPHGPIEVRAAFVPQRSARAEVPGQQEINVTRMIVDAHLEGVSLWSRVEYAGRQWDIVSPPAYHHGDRRTRHWSIDIRERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF56</accession>
    <name>A0A2G1XF56_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2017 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19665</name>
        <name evidence="3" type="ORF">CYQ11_11130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49860">
        <property type="protein sequence ID" value="PHQ49860"/>
        <property type="gene ID" value="BLA24_19665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13364">
        <property type="protein sequence ID" value="PPT13364"/>
        <property type="gene ID" value="CYQ11_11130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="10"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="21213" checksum="B02AE0BECE24A478" modified="2018-01-31" version="1">MAGHFEPLPGGGAAVALDEVEVSILRSLAVQLLELIGPGEAEGPEAADPLARLFAEGPSEPPADPALARLFPDAYGTPGAEQDQQERAHASEFRRYTENDLRARKREDALGVVRSLDSLTVAGDSAAVLRLSPDGCRQWLGALNDLRLTIGARLEITDEDDGEALFRLPDEDPRKPMVMAYLWLGGLQETLVEALMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFC6</accession>
    <name>A0A2G1XFC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Cytochrome C biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19935</name>
        <name evidence="4" type="ORF">CYQ11_10855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49905">
        <property type="protein sequence ID" value="PHQ49905"/>
        <property type="gene ID" value="BLA24_19935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13319">
        <property type="protein sequence ID" value="PPT13319"/>
        <property type="gene ID" value="CYQ11_10855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="275" mass="28431" checksum="68E08442AB157665" modified="2018-01-31" version="1">MTDIGYLAAFLGGALALVSPCSALLLPAFFAYSLASPGRLLARTGVFYLGLATTLVPLGAASTAASRLFNGHRDLLVTAGGWTVIALGAAQILGLGFASRKAQAAAGRITPRSAASTFLLGCVYGLAGFCAGPILGAVLTVTAVGGDPVYGASMLAVYALGMALPLFVLALFWDRFQLGGRGWLRGRELRLGRLRLHTTSLVSGLFFIGIGVLFLAYDGTTGLPGVLDADQEFRLEQLASRVGNAVPDYAVLAVVALVVAGVLARIAFRRDPGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD7</accession>
    <name>A0A2G1XFD7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iolD</name>
        <name evidence="7" type="ORF">BLA24_20275</name>
        <name evidence="8" type="ORF">CYQ11_10510</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49956">
        <property type="protein sequence ID" value="PHQ49956"/>
        <property type="gene ID" value="BLA24_20275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13266">
        <property type="protein sequence ID" value="PPT13266"/>
        <property type="gene ID" value="CYQ11_10510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="219"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="418"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="625" mass="66307" checksum="28A9F755D3998000" modified="2018-01-31" version="1">MTRRLTVAQALVEFLAHQYTERDGRRRRLVAACWGIFGHGNVAGVGQALLETGDALPYLQGRNEQAMVHAAVGYARQCDRLSAHAVTTSIGPGATNLVTGAALATVNRLPVLLLPGDTFATRPADPVLQQLEHPGAGDVSVNDCLRPVSRYFDRVVRPEALIPAALQAARVLADPVETGAVTLALPQDVQAEAYDWPEDFFTDRVWHVRRPAPDPAELAAAVSAVRAARRPLLIAGGGVHHSEAEDALRALADATGIPVASTQAGKGSLRHDHPADVGGVGHTGTAVADALARGADLVIGAGTRYSDFTTASSTLFAAPDVRFVNLNISSYDAHKLAGLPLVADARAGLEALTEGLKGHRVAEDYVRAYTAGKAEWEAAVDYAYSWRADGDGRRPTQAQVVGALDAVVGDEDVVINAAGSLPGDLHKLWRARSRRQYHLEYGYSCMGYEIPAAIGVRLAAPDRPVWALVGDGTYLMMPTELVTAVQEGIAIKVILVQNHGYASIGGLSRAVGGEGFGTAYRFRAPDGTYTGDPLPVDLAANAASLGMSVLRARTVLELRDALAEARASDRPTCVHVETETADPVPGTPPAQAWWDVPVAETATRPAAVAAREEYERDAAARRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFJ8</accession>
    <name>A0A2G1XFJ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2637 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20415</name>
        <name evidence="4" type="ORF">CYQ11_10370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49981">
        <property type="protein sequence ID" value="PHQ49981"/>
        <property type="gene ID" value="BLA24_20415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13242">
        <property type="protein sequence ID" value="PPT13242"/>
        <property type="gene ID" value="CYQ11_10370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="484" mass="52599" checksum="1D1EC4461270C445" modified="2018-01-31" version="1">MSDLGSWQEQRRRDRLADREQDRADTAARAVERREDRRLEREQDRADRAAARSEKRQDKAGRAERWRTRRAWLVDHGALMCTGVVMACAIVPALAAQFTALSTAGVGPLLAALLAAMLEGGAWAATFGAAEAARQDRPTGRYRAATWACAAVAAAINFSHGSHDYGLWLGVVLAVASLFAVGMWELHLNGSHTPSREERERARHERRRRWHHRKVCRIAGRLITAAPHGTLTAEEAFIAAWRVHHGANPGLTAQLLADRLAAEAGLGEVVEQAADSGPQRVTARLWTVGDEGLPVLGRTCPVPLKKQENRPDSVADRSMAGLRVSAPVPLDGSADSSAARPLAPLPVRPVRKAADGPAGKPRSRAVAESTGSAPRRATGRVPVAARYEAAGRRTDDELLDTARKQTAAWPDDELNAERLRTTLRIGAAKARYLRDILQAERAEITAQFQDDETDRRHGLHLVTDDAATMPAGLQDLLVPSGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFR8</accession>
    <name>A0A2G1XFR8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20755</name>
        <name evidence="4" type="ORF">CYQ11_10025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50041">
        <property type="protein sequence ID" value="PHQ50041"/>
        <property type="gene ID" value="BLA24_20755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13181">
        <property type="protein sequence ID" value="PPT13181"/>
        <property type="gene ID" value="CYQ11_10025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="11844" checksum="F6538D6483A9F38F" modified="2018-01-31" version="1">MAKDYDSQLLESVSVRRRRMRDALLFGAQRARRTADEKLGKVFAGIAIAAVLCAGCVGWSFIQNTLAKQKEQQKQQERRYAPAAPSPSTATEPSPAQTEAAKQPKGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFZ3</accession>
    <name>A0A2G1XFZ3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_21495</name>
        <name evidence="10" type="ORF">CYQ11_09290</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50156">
        <property type="protein sequence ID" value="PHQ50156"/>
        <property type="gene ID" value="BLA24_21495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13060">
        <property type="protein sequence ID" value="PPT13060"/>
        <property type="gene ID" value="CYQ11_09290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="41901" checksum="A3AC00B5890DF458" modified="2018-01-31" version="1">MGGGPAAAAPERSAARSAASAAITLEVAPVQTRTPTLPQVPADPAPTVPQQAEPPASEPPALTEEAAPEPAARADTSGPSSDLFRQYLREIGRIPLLTAAEEVELARRVEAGLFAEEKLGNTPDLDTQLALDLDRLVVLGRMAKRRLIEANLRLVVSVAKRYIGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTAEEVAVHLDLSEERVSEVLRLAQEPVSLHAPVGEEDDVALGDLIEDGDATSPVESAAFLLLREHLEAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRIFGVTRERIRQIESKTLNKLRDHAFADQLRGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG34</accession>
    <name>A0A2G1XG34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21140</name>
        <name evidence="4" type="ORF">CYQ11_09645</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50099">
        <property type="protein sequence ID" value="PHQ50099"/>
        <property type="gene ID" value="BLA24_21140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13121">
        <property type="protein sequence ID" value="PPT13121"/>
        <property type="gene ID" value="CYQ11_09645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="28824" checksum="42F83B98D7AAC955" modified="2018-01-31" version="1">MALLRASDYERMLDLVVEVLETDAPESVWPLMAAHLREAFACDTVIFAELFLPRQSGRAEGWAPENLGDSVRDIVERRMRQRHPLIAYLEANQQRPVTMTQICEHWRHSLWRSEARRDFGTTHQMGLPMPGVPGAVRAVSLGRKGDFTDHELALATRIQPLLLSADKHIRELRRVREERERRSGVPALPHHDLTPRELTVLGLLAEGLTTEAIGRRLAISPHTVNRHLEKVYRKLGTNNRVSTVLLARGTGLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGA0</accession>
    <name>A0A2G1XGA0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_22210</name>
        <name evidence="9" type="ORF">CYQ11_08575</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50270">
        <property type="protein sequence ID" value="PHQ50270"/>
        <property type="gene ID" value="BLA24_22210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12944">
        <property type="protein sequence ID" value="PPT12944"/>
        <property type="gene ID" value="CYQ11_08575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ50270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="433" mass="46126" checksum="600DCD7461818AB1" modified="2018-01-31" version="1">MTEANTTTGSERNAGPAADTASPRPSRRALLGWGGAGLALGAAAAGGTAAALRTGADAQPVASGGDAVPFHGAHQAGIATPVQDRLHFASFDVTTTDRAALVKLLQDWTAAAARMTAGHEVGDGAISDNEELPPDDTGEALGLKPSRLTLTFGVGPGLFEKDGKDRFGLRARRPKALIDLPAFPGDNLDPARSGGDLCVQACADDPQVAVHAIRNLARIGMGKVAIRWSQLGFGKTSSTTPDAQTPRNMMGFKDGTRNIAGTETARLDKHVWVGEKDGPDWMTGGSYLVARRIRMHIETWDRTSLREQEDVFGRDKAEGAPVGREREHDEPLLKAMKPDAHVRLAHPDSNNGVTILRRGYSFTDGTDGLGRLDAGLFFIAYQRDVRDGFVPLQTNLARNDALNEYIQHVGSAVFAVPPGVRDKGDWWGKALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGB4</accession>
    <name>A0A2G1XGB4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_21630</name>
        <name evidence="6" type="ORF">CYQ11_09155</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50179">
        <property type="protein sequence ID" value="PHQ50179"/>
        <property type="gene ID" value="BLA24_21630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13038">
        <property type="protein sequence ID" value="PPT13038"/>
        <property type="gene ID" value="CYQ11_09155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="148"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="223" mass="24318" checksum="E1C338AE234E88B1" modified="2018-01-31" version="1">MTYVQRAAERFRGGDPEAGIETRHAFSFSGFYDPDNVRFGPLAACNEERLAGGAGFAEHPHRDVEIVTWVVEGELAHEDSAGHVVTVRPGDLQRLSAGSGVRHVERNAGSVPLRFVQMWLTPSEFGGDPSYEVVRGIADGTPYALERADAVLHVRRLRDGERTALPDAPWLYVHVVRGAVRTAGEVLREGDAARLTDAVDVEAEAIGSAELLAWEMHAEPHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGD8</accession>
    <name>A0A2G1XGD8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_22335</name>
        <name evidence="2" type="ORF">CYQ11_08450</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50294">
        <property type="protein sequence ID" value="PHQ50294"/>
        <property type="gene ID" value="BLA24_22335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12920">
        <property type="protein sequence ID" value="PPT12920"/>
        <property type="gene ID" value="CYQ11_08450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="159" mass="17427" checksum="F1E6C72C9965A9EF" modified="2018-01-31" version="1">MSTEGTYTPFGGELERGVKYAVQWRADPRYVLCGDLTHGVVDVRDRATAAERDYAWHIDAATGTVTLAAAADEHTPRVLTLLLGRTGLRPVLRRLVSPRVSTQRWNWTGRALMSHNQPADDKLAVHVGDRSADGGYGLRMVLPTGGVPAHEWQLLRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGL1</accession>
    <name>A0A2G1XGL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22255</name>
        <name evidence="4" type="ORF">CYQ11_08530</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50279">
        <property type="protein sequence ID" value="PHQ50279"/>
        <property type="gene ID" value="BLA24_22255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12935">
        <property type="protein sequence ID" value="PPT12935"/>
        <property type="gene ID" value="CYQ11_08530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758506" evidence="2">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="6894" checksum="C45F24437B667063" modified="2018-01-31" version="1">MPRLALYALAVCALSLAAAVVSFARGSWLGVVWILLLGVSSNIAWYYVRKAKNDKAAEEGLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGU1</accession>
    <name>A0A2G1XGU1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">BLA24_16605</name>
        <name evidence="7" type="ORF">CYQ11_16680</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_071962293.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50464">
        <property type="protein sequence ID" value="PHQ50464"/>
        <property type="gene ID" value="BLA24_16605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14281">
        <property type="protein sequence ID" value="PPT14281"/>
        <property type="gene ID" value="CYQ11_16680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="165" mass="18642" checksum="F0DFD5B5FF864670" modified="2018-01-31" version="1">MEFDVTIEIPKGSRNKYEVDHETGRIRLDRRLFTSTSYPADYGFVENTLGEDGDPLDAMVILDEPTFPGCLIKCRAIGMFRMTDEAGGDDKLLCVPANDPRVEHLRDIHHVSEFDRLEIQHFFEVYKDLEPGKSVEGADWVGRAEAEAEIEASYKRLEAAGGSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH43</accession>
    <name>A0A2G1XH43_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50552">
        <property type="protein sequence ID" value="PHQ50552"/>
        <property type="gene ID" value="BLA24_17195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="472" mass="51316" checksum="3F7C1983BC3A60F8" modified="2018-01-31" version="1">MAGPAIQAGAIHGDVNITMTGPPSAVEATDEALAEALRKSSQIWRARFSSVDLVNLPRMAMLAQSNAVAAAARKAGLDSTRPFGGQGMAPGEFIRIVRPLFETWDAEAVTLCERTAEKVHRGLLVSFEGAMRCNNPPEVPLKEPTGVLTKDPHLVFRVGARKVVITFDPRWLTTSTATTTLHDAARESLVFSGIGTVASEGGGQIRISALVFGQPETLAQAQFEYAKKSVVPAPPGLTSADFRNELSRSELSELYRDKSWERGTVSRKSIALLFDEDEVLPGQIDREVLTQVSRVVPEYRRDLGVAVASLFFNGQGVAAADLAAHFLAREPALWKSLTVPGLTTLIGSCNLAVSTVSGLSEDQAADLHAAMSEAAASYLGCVEVDRDLPLHKRLLPAHDDYHVAGAELRLVYSAARRILDEANGEDLEMPLNEWRQRGLFRSVEWEEDLRQSAAEEKEASMFIETWLNAQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHB7</accession>
    <name>A0A2G1XHB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_17035</name>
        <name evidence="5" type="ORF">CYQ11_16245</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50529">
        <property type="protein sequence ID" value="PHQ50529"/>
        <property type="gene ID" value="BLA24_17035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14217">
        <property type="protein sequence ID" value="PPT14217"/>
        <property type="gene ID" value="CYQ11_16245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="407"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="626" mass="67457" checksum="927823B705E7E9DC" modified="2018-01-31" version="1">MGGMTESNGSPRGDTAMPDWETRFRAPRVGLPRWAKDAPDRSLFTSNATGTFELYAWDRTTGEHRQVTDRPNGTTGGVLSPDGEWIWWFSDTDGDEFGVWVRQPFHGGEDRPATPGLEPSYPDGLALGRDGTAVVGRSTDKGGSTVHLVRPGQEPVEIYRHQQSAGVGGLSHDGSLIAVEHTEHGDAMHASIRVLRADGSTVGELDDTRGGTEELGLSAMGFAPVDGDSRLLVGHQRRGRWEPMMWDPVTGEETALVIDLPGDLDADWYPDGTALLIDHSHHARSELWRYELASGELTRLDTPPGTVSGALPRPDGTVEFLWSSAAKPPVVRSTAGHVVLTPPAVPHGIAQAPDSVPVSDIWVEGPGGKVHALVQKPAGEGPFPTVFDIHGGPTWHDSDAFAAGPAAWVDHGYAVIRVNYRGSTGYGRAWTDALKHRVGLIELEDIAAVREWAVASGLADPERLVLAGGSWGGYLTLLGLGTQPEAWAVGLAAVPVADYVTAYHDEMEALKALDRTLLGGSPEEVPERYAASSPLTYVDRLRAPVYISAGMNDPRCPIRQIDNYVERLEELGHPHEVYRYDAGHGSLVVEERIKQLRLEIAFADRHLNPRGSQGGPAEPALPGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHH6</accession>
    <name>A0A2G1XHH6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gnd</name>
        <name evidence="4" type="ORF">BLA24_17980</name>
        <name evidence="5" type="ORF">CYQ11_15295</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50683">
        <property type="protein sequence ID" value="PHQ50683"/>
        <property type="gene ID" value="BLA24_17980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14062">
        <property type="protein sequence ID" value="PPT14062"/>
        <property type="gene ID" value="CYQ11_15295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="160"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="292" mass="31578" checksum="7E777533B9A01ED1" modified="2018-01-31" version="1">MELGLVGLGKMGGNMRERIRRAGHTVIGYDRNPDLADVHSLQELVDSLQGPRVVWVMVPAGAATQSTIDELGELLSPGDIVVDGGNSRWTDDEKHAEELAAKGIGFVDCGVSGGVWGLENGYALMYGGDAENVAKVQPVFDALKPEGDFGSVHAGKVGAGHFAKMVHNGIEYAMMQAYAEGWELLEKVESVTDVREIFRSWQEGTVIRSWLLDLAVNALDEDEHLDKLRGFAADSGEGRWTVEAAIDNAVPLPAITASLFARFSSRQEDSPQMKMIAALRNQFGGHAVESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHI0</accession>
    <name>A0A2G1XHI0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BLA24_17975</name>
        <name evidence="14" type="ORF">CYQ11_15300</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50682">
        <property type="protein sequence ID" value="PHQ50682"/>
        <property type="gene ID" value="BLA24_17975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14063">
        <property type="protein sequence ID" value="PPT14063"/>
        <property type="gene ID" value="CYQ11_15300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="249"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ50682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT14063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="376" mass="39655" checksum="45D25E9CD524D630" modified="2018-01-31" version="1">MKIRVERDVLAEAVAWAARSLPARPPVPVLAGLLLKAEDGTLSLSGFDYEVSARVSVEADVEEDGTVLVSGRLLADICRALPNRPVEISTDGVRVTVVCGSSRFTLHTLPVEEYPALPQMPTATGTVPGEVFASAVAQVAIAAGRDDTLPVLTGVRIEIEGDTVTLASTDRYRFAVREFMWKPETPDTSAVALVPAKTLLDTAKSLSGGDTVSLALSGSGAGEGLIGFEGAGRRTTTRLLEGDLPKYRTLFPTEFNSAAVIETAPFVEAVKRVALVAERNTPVRLSFEQGVLILEAGSSDDAQAVERVDAKLDGDDISIAFNPGFLLEGLSAIDSPVAQLSFTTSTKPALLSGKPAVDAEADDAYKYLIMPVRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHJ3</accession>
    <name>A0A2G1XHJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_17575</name>
        <name evidence="8" type="ORF">CYQ11_15700</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50609">
        <property type="protein sequence ID" value="PHQ50609"/>
        <property type="gene ID" value="BLA24_17575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14136">
        <property type="protein sequence ID" value="PPT14136"/>
        <property type="gene ID" value="CYQ11_15700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="241" mass="24843" checksum="A90C94F2DE79C059" modified="2018-01-31" version="1">MSLYHPTVARLTYRGLLGRRRAAILFALPALLLVISAAIRFLTGADDETATNVLGGFALATMVPLIGVIAGTGAIGPEIDDGSVVYLLAKPVKRPTIILTKLVVAVGVSVLFSAVPTLMAGFLLNGNSQQIAVAYAVAAAIASVAYSAIFLFLGTVTRHAVVAGLVYALVWETLFGNLIAGARTLSVRQWALALAQKIGGEGAITSDVGLPLAVTLLVGVTVAATYCAGRKLRSLTLAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHL5</accession>
    <name>A0A2G1XHL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18360</name>
        <name evidence="4" type="ORF">CYQ11_14920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50744">
        <property type="protein sequence ID" value="PHQ50744"/>
        <property type="gene ID" value="BLA24_18360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13999">
        <property type="protein sequence ID" value="PPT13999"/>
        <property type="gene ID" value="CYQ11_14920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="601" mass="64161" checksum="0AA2BDA8BF688F83" modified="2018-01-31" version="1">MAPHARVRAPELIGKGGWLNTGDNDLSLAALRGKIVIVDFWTFCCVNCLHVLDELRELEEKHRDTVVIIGVHSPKFVHEADHQAVVDAVERYGVHHPVLDDPELATWKQYAVRAWPTLVVVDPEGYVVAQHAGEGHAHAIARLVAELEAAHEAKGTLRRGDGPYVPPEPEATDLRFPGKALLLPGGNLLVSDTTRHQLVELAADGESVVRRVGTGERGLSDTPATFNEPQGLALLPDGKVIVADTVNHALRTYDPATGAVETVAGTGRQWWQGSATSGPARDVDLSSPWDVAWFADRVWIAMAGVHQLWTYDPAAGTVEVAAGTTNEGLVDGPAAEAWFAQPSGLAAGADRLWLADSETSALRYVERDGEGFAVRTAVGAGLFDFGHRDGAADQALLQHPLGVTVLPDGSVAVSDTYNHALRRYDPATGQVTTLATDLREPSDAVLVDDDIVVVESARHRLTRLRLPEEAVRVESVAHRTQRAATEIAPGTLRLDVVFQAPRGQKLDTRYGPSTRLLVSSTPPELLAEGAGQGTDLGRDLVLADGVGEGVLHVSAMAASCDDDPANEYPACHVHQQDWGVPVRVVEGGAGRLPLVLAGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI73</accession>
    <name>A0A2G1XI73_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50952">
        <property type="protein sequence ID" value="PHQ50952"/>
        <property type="gene ID" value="BLA24_14245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="810" mass="81812" checksum="5C30C00AA45F28E3" modified="2018-01-31" version="1">MPSFCPACGSAFVPEARFCMKCGRERPEGDSEGGAPAGEAPAAGKAAPAPATVPAMPATAPPPPPPARPPLPGAPPPPYAPAAQAPPSPFALFLRRTFAGDWAGAAKAALWPAGLLLVLTVAISAPSYGDYEGMRFSNWSDRFQVVAGLLMQGLGGTLEVETRSGGLFSLFMRGSGSISVWPLTVTALWAAAVALGARRLRASWPAGAGGGAEAALRVALLSAGVVLVLALIGQPDLELVTVSTTPWLAGLVSFALAGAVAGAVLCRDELAVRLGAGAQMVVRAWGTALRALGLSVALCAVIVFVVLAANQDEVGEWTWAGSIPVLVNLGLMGLGLSWGAGVEGENTDHGAHKSGTLGLSELGAAVGDWAQVGALAVGAVCAVILAVLAARRSADRFEQVLSGVFFLGTVWLLSFVSGAATEMAPAPTSFSARPRGMEASVGTNAGELLLFGLLWTAGALLLAAVIGRGGGTAGTGPGLGVGKAAGGAVAPVPPMPAVSPAPASPASPPAPAAPPAPPAPAEAPAAPAPQAAPPAPPASPAYAIPAPAPAPAPAPARSSTGRVLTWVAIGVAAFLVGGGAVGGVMLVGKSGDTKKDGSKDGKPVVVRSDAPPEGADGDGREGVASPSAAPSAGESASASPSPGASRPGQVVVPDRARATPPQGFERITSPEGFTLAVPEGWHREDKGSRQVDFAGPTGLAHLRVGMAASEGKSAYDHFQEMEKVVGQQEGYKRLKMTPNTFQGRPGALWEWTRTEKGTGRVVHAVDQAYVDEHGTEFAVLYEDRDEYWPVVHKTFDTALEYWWSGPADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI84</accession>
    <name>A0A2G1XI84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_18340</name>
        <name evidence="6" type="ORF">CYQ11_14940</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50901">
        <property type="protein sequence ID" value="PHQ50901"/>
        <property type="gene ID" value="BLA24_18340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16573">
        <property type="protein sequence ID" value="PPT16573"/>
        <property type="gene ID" value="CYQ11_14940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23931" checksum="011989CCFD56E9AA" modified="2018-01-31" version="1">MPSAPAVRTARPPAAERVYAHVKDAVLHRRYEGGTLLTEGDLAEAVGVSRTPVREALLRLEGEGLLRLYPKKGALVLAVSAQEIADVVETRLLVEKHAAAKAVPAPPGLLARLGELVEDMRRQAEAGDLAAVSRSDRAFHAEIVRSAGNQILANLYEQLRDRQLRMGVAVMHAHPDRIAKNIAEHTDILQALRAGDAEAAVEVVDRHVSWVRNLARGDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIQ5</accession>
    <name>A0A2G1XIQ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15190</name>
        <name evidence="4" type="ORF">CYQ11_12880</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51116">
        <property type="protein sequence ID" value="PHQ51116"/>
        <property type="gene ID" value="BLA24_15190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13661">
        <property type="protein sequence ID" value="PPT13661"/>
        <property type="gene ID" value="CYQ11_12880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="159" mass="17653" checksum="737ED2106C283760" modified="2018-01-31" version="1">MMTGVERVVQKVSSTRSFARVAPHFVPAIDRAVHRLTRGRVLLSASLLPGAVLVSTGAKSGLTRRTPLACIPADPADSAWLLVGSNFGRPGHPAWTANLLAHPDVEINWRGRDIPVRARLLSGAEREGAWATALAFWPPYARYQERVEREIRLFRLDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ13</accession>
    <name>A0A2G1XJ13_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15775</name>
        <name evidence="4" type="ORF">CYQ11_12300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51213">
        <property type="protein sequence ID" value="PHQ51213"/>
        <property type="gene ID" value="BLA24_15775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13563">
        <property type="protein sequence ID" value="PPT13563"/>
        <property type="gene ID" value="CYQ11_12300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MecA_N" evidence="2">
        <location>
            <begin position="56"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="266"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="540" mass="54759" checksum="3E0D346A398089C8" modified="2018-01-31" version="1">MRRGAKIAIGAVAAAVAGAAGLGAYNIVDAVAGGGSGTNAAAAPERTGPPSAGETEETARAFLTAWAAGDTEKAAALTDNAEAAGTALTGYREAAHVEKVTLRQGTATGAKVPFSVTAEIALGKQRSTWSYDSALTVTRGRTSGRPLVDWQPAVLHPELTQGQSLHTGVTRTAPVTAVDRDGNELKPEDFPSLASVLPELRKRFGEKAGGEPGVEVRVETAGAAAQAEPKTLHVVSKGTPGKLTTTIDAAVQRAAEAAVSRHDDASVVAVRPSTGEILALANAKKTEFNPAVSGQTAPGSTMKIVTSALLLEQGKATPGKPLPCPKTATYGMTFHNVEHSENPGATFAQDFAASCNTAFVSLAGQLSDDALAAEARDVFGLGLEWKTGIATFDGKVPADGGAGKAAAMIGQGRVQMSPLNMASVAATVRSGSFRQPYLVDPSVDGRQLARAPRALPDDAARDLRSMMRLTAVSGTGSKAMAGLGGDVGAKTGSAEVDGQTTPNGWFTGYRGDLAAAAVVPRGGHGGDSAGPLVAAVLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ16</accession>
    <name>A0A2G1XJ16_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">BLA24_15975</name>
        <name evidence="12" type="ORF">CYQ11_12100</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51248">
        <property type="protein sequence ID" value="PHQ51248"/>
        <property type="gene ID" value="BLA24_15975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13527">
        <property type="protein sequence ID" value="PPT13527"/>
        <property type="gene ID" value="CYQ11_12100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="642"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="828"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ51248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1177" mass="128192" checksum="96DCE546AEE23838" modified="2018-01-31" version="1">MSLHGLLDAVVHDPALAEAVKAAGDGNRPHVDLVGPPAARPFAVAALARDAGRPVLAVTATGREAEDLAAALRSLLPADSVVDYPAWETLPHERLSPRSDTVGRRLAVLRRLAHPRADDPAAGPVSVVVAPVRSVLQPQVKGLGDLEPVSLRAGRSADLEEVVAALAAAAYARVELVEKRGEFAVRGGILDVFPPTEEHPLRIEFWGDDVEEIRYFKVADQRSLEIAEHGLWAPPCRELLLTDSVRERAAALAEEHPELGELLGKIAEGIAVEGMESLAPVLVDDMELLLDVLPAGSMAVVCDPERVRTRAADLVATSQEFLQASWAATAGGGEAPIDVDAASLWGIADVRDRARELGMMWWSVSPFAAGEEDLDGDTLKLGMRAPESYRGDTARALADTKGWLADGWRTVFLTEGHGPAARTVEVLGGEGIPARLDADLAELAPSVVQVSCAGVDSGFVDPGLKIAVLTEADLTGQKSASKDLGRMPVRRRKTIDPLTLQAGDYIVHEQHGVGRYLEMVQRTVQGATREYLLVEYAPAKRGQPGDRLYIPTDQLEQVTKYVGGEAPTLHRLGGADWTKTKARAKKAVKEIAADLIKLYSARMAAPGHSFGADTPWQRELEDAFPYAETPDQLTTIAEVKEDMEKSVPMDRLVCGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLVQQHFGTFSERYSQFPVVVKALSRFQTDTEAKAVLEGLREGSVDIVIGTHRLFSSETKFKDLGLVIVDEEQRFGVEHKEQLKKLRANVDVLTMSATPIPRTLEMAVTGIREMSTITTPPEERHPVLTFVGPYDQKQIGAAIRRELLREGQVFYIHNRVESIDRAAAKLREIVPEARIATAHGQMGESALEQVVVDFWEKKFDVLVSTTIVESGIDISNANTLIVERGDNFGLSQLHQLRGRVGRSRERGYAYFLYPPEKPLTETAHERLATIAQHTEMGAGMYVAMKDLEIRGAGNLLGGEQSGHIAGVGFDLYIRMVGEAVADYRASVEGGEEEPEAPLEVKIELPVDAHVPHDYAPGERLRLQAYRAIASANSEEDIKAVREELTDRYGKLPEPVENLLLVAGLRMLARSCGVSDITLQGSNVRFGPVELRESQELRLKRLHPRTVMKPATQQILVPRPATRPIGGKPLVGRELLAWTGEFLTTILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ19</accession>
    <name>A0A2G1XJ19_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15845</name>
        <name evidence="3" type="ORF">CYQ11_12230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51226">
        <property type="protein sequence ID" value="PHQ51226"/>
        <property type="gene ID" value="BLA24_15845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13550">
        <property type="protein sequence ID" value="PPT13550"/>
        <property type="gene ID" value="CYQ11_12230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="99" mass="10570" checksum="2E80D8026FB2CC37" modified="2018-01-31" version="1">MTDHQREGGESGPVPATAARLFDIRRVIGGLFTVYGLILTVAGVLADEEDLRKAEGVNINLWAGLGMLALGGFFLLWLTLRPAPPRPDPPADPRPGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJA4</accession>
    <name>A0A2G1XJA4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16325</name>
        <name evidence="4" type="ORF">CYQ11_11750</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51305">
        <property type="protein sequence ID" value="PHQ51305"/>
        <property type="gene ID" value="BLA24_16325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13469">
        <property type="protein sequence ID" value="PPT13469"/>
        <property type="gene ID" value="CYQ11_11750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="337" mass="36428" checksum="211F2408B354F179" modified="2018-01-31" version="1">MPDQQPPAVSVIMPVLNEERHLRTSVRHILEQEYAGELEVVIALGPSTDRTDEIAAELVREDSRVHTVPNPTGRTPAALNAAIKASRHPIVVRVDGHGMLSPDYIATAVRLLEETGAQNVGGIMHAEGENDWERAVAAAMTSKIGVGNAAFHTGGSAAPADTVYLGVFRREALEQQGGYNEEFIRAQDWELNFRIREAGGLIWFSPELKVSYRPRPTVKALAKQYKDYGRWRHVVARYHQGSINLRYLAAPTAVIAIAAGVVAGAVITPWGFVVPAGYLAAITAGSVPAGKGLPVGARLRIPVALATMHMSWGYGFLTSPRSLAKKVIASRRPAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK0</accession>
    <name>A0A2G1XJK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13940</name>
        <name evidence="2" type="ORF">CYQ11_01635</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51428">
        <property type="protein sequence ID" value="PHQ51428"/>
        <property type="gene ID" value="BLA24_13940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11769">
        <property type="protein sequence ID" value="PPT11769"/>
        <property type="gene ID" value="CYQ11_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046038">
        <property type="entry name" value="DUF5996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19459">
        <property type="entry name" value="DUF5996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="312" mass="34816" checksum="000C75EDF1667124" modified="2018-01-31" version="1">MEIFPPVPLAEWKASKETLHRFAQVVGKIRLAGSVRRNHWWNVPYHVTGSGITTRPMGLTDGNPVFTIDFDFVGHRLVVRGLDGSESSFSLLGQSVSSFHRRTLAALHAIGVEVTMEHPHPFDLPDGRRPFAEDTEHAAYDPFWVNRYWQVLSQVGLVLEAFSAGYSGKVSPVHHFWHTFDIAVTRFSDRKVEQGPDTDPVTREAYSREVISAGFWFGDDAFPRPTFYSYAAPEPEGLADEPLLPEAARWVDFRGGRLAVLDYDDVRGGEDAPRRVLDFYESVYRAAARRAGWDVEGLACPGGVTDPVVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK9</accession>
    <name>A0A2G1XJK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13700</name>
        <name evidence="3" type="ORF">CYQ11_01395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51390">
        <property type="protein sequence ID" value="PHQ51390"/>
        <property type="gene ID" value="BLA24_13700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11730">
        <property type="protein sequence ID" value="PPT11730"/>
        <property type="gene ID" value="CYQ11_01395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="282" mass="31719" checksum="E45476F022EB3536" modified="2018-01-31" version="1">MKDVALPAGVIEYDETGSGPPVVLLHGLMMDHRLWDRVLPLLPKGFRYVCPVLPLGSHRRPMRPDADLTLPGQVRLVADFLDALDLDDVTLVHTDWGGGLFLTAHGLDRRVARQVILPCEAFDNFPPGLPGKTVTLASRLPGGLRLGARQLRVRRLRQSPMMLGQMARRPIPDELIHRWTEPLLRHPGIRRDLSAYCRGRFDKKELVRDTEALRRFTGEALVLWSPDNRVMPPEHGHRLAELLPAGRYAEVPGAYVLSMLDEPETVAREIGRFLTGSADRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK27</accession>
    <name>A0A2G1XK27_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12970</name>
        <name evidence="3" type="ORF">CYQ11_17330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51604">
        <property type="protein sequence ID" value="PHQ51604"/>
        <property type="gene ID" value="BLA24_12970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14397">
        <property type="protein sequence ID" value="PPT14397"/>
        <property type="gene ID" value="CYQ11_17330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304764" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="69" mass="6795" checksum="0B8F174CAE646931" modified="2018-01-31" version="1">MNPLRRVLTTLAATALLCVGSAALAAPAQAEVNANLLGGILYATSNGLTHVGSGGSDLVALPNLLSPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKE3</accession>
    <name>A0A2G1XKE3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11435</name>
        <name evidence="2" type="ORF">CYQ11_02670</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51697">
        <property type="protein sequence ID" value="PHQ51697"/>
        <property type="gene ID" value="BLA24_11435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11946">
        <property type="protein sequence ID" value="PPT11946"/>
        <property type="gene ID" value="CYQ11_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="23286" checksum="45086BEEB69BA05A" modified="2018-01-31" version="1">MPEFRLEPPPERSGLAEFPAVVEPPISDIPAPAAPPGPAEPVTWERTVTPSSEELLDRAVPLLLADARVRTALDGHRYVFLGASLLADDKDRTTPATLVLVHDYTDGRTLEITLDADEHPAVLALAESAAQPGLSDAEIARAVAVARTHSEAVRRLPAYHVPMVLLTSDVHEGDEHHGHRRAYVGFGQPDRRLPRLRVVVDLGEERVLGPGGGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKE6</accession>
    <name>A0A2G1XKE6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_11460</name>
        <name evidence="6" type="ORF">CYQ11_02695</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51702">
        <property type="protein sequence ID" value="PHQ51702"/>
        <property type="gene ID" value="BLA24_11460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11951">
        <property type="protein sequence ID" value="PPT11951"/>
        <property type="gene ID" value="CYQ11_02695"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758507" description="YkuD domain-containing protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="120"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="236" mass="25416" checksum="8702C4DCA4843DD0" modified="2018-01-31" version="1">MTSSPSKTARRLGVLLGAACLTVPLTVALGGTAQAAPSSCTAGTGPFQKNAERFLGRTVDGRQSAADCRAIRAFQLDHGISPAIGYAGPVTWSVMDLVGKQRSAGDRPNAAGKCPVDKGRVACVDLTRQLSWIQDGSRLKFGPVPIRSGRDGYETRTGLKRVYWRSVDHWSTLYKVRMPYSQFFDGGQAFHAIDGSVWSAPGSHGCVNMRRADAKKYWSLLKNGDDVYVYGSKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU5</accession>
    <name>A0A2G1XKU5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyoverdine biosynthesis protein PvcB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TauD/TfdA family dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11670</name>
        <name evidence="5" type="ORF">CYQ11_02910</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51852">
        <property type="protein sequence ID" value="PHQ51852"/>
        <property type="gene ID" value="BLA24_11670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16316">
        <property type="protein sequence ID" value="PPT16316"/>
        <property type="gene ID" value="CYQ11_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="30328" checksum="184AD6BE5321EB8F" modified="2018-01-31" version="1">MEPFGVRVDAATPGAPVTELPVEGLRELVRSHHLLLLRGFASPGGAEELAEYSARWGELGMWPYGAVLELVEHDEPDDHIFDHRYVPLHWDSMYREQIAQFQVFHCVSAPGEGDGGRTTFSQTAAVLREADPAQRALWERVTGRYRREVAQVYAGECVSPVVTTHPDGFPVIRYNEPVPPDEEFLNHPDLEFTGVPEELLPEFHSTLRAALYDPRHLYAHEWRTGDMVVADNYTLLHGREAFTSRSPRHLRRVHVLGTPPLKNTALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL08</accession>
    <name>A0A2G1XL08_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1772 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_10680</name>
        <name evidence="4" type="ORF">CYQ11_00875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000128">
        <property type="protein sequence ID" value="PHQ51912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51912">
        <property type="protein sequence ID" value="PHQ51912"/>
        <property type="gene ID" value="BLA24_10680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11643">
        <property type="protein sequence ID" value="PPT11643"/>
        <property type="gene ID" value="CYQ11_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758528" evidence="2">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="161" mass="17076" checksum="0868EE4BF5208AD3" modified="2018-01-31" version="1">MRTRLFQALSLFSTGLLAGSFAYGAANLVPTFNAVPIDMRLDFHTALMRMNGITMQATMAVSALSTLALTASKRGRTRVLAGAAGCLVVSSFLITRFGNVPINGRIKQWAATTPPADHAEVLRRWELFNDARTVTAASAFGLLVLLALPAAATRRPAGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XL32</accession>
    <name>A0A2G1XL32_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC family oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_11515</name>
        <name evidence="5" type="ORF">CYQ11_02750</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51849">
        <property type="protein sequence ID" value="PHQ51849"/>
        <property type="gene ID" value="BLA24_11515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16313">
        <property type="protein sequence ID" value="PPT16313"/>
        <property type="gene ID" value="CYQ11_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="3">
        <location>
            <begin position="389"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="515" mass="56246" checksum="4B74885B3572DE08" modified="2018-01-31" version="1">MRRYDDGDEVDMAVVGCGAGGATFAQRLAHAGWRVVCLEAGPFWDPEKDWVSDEWGSHHLYWNEPRVVGGSHPVPLGSNNSGRGVGGSMVHFAGFAPRLHPSDFRTRSLDGVGADWPLEYGELKPFYERLERELPVAGQFWPWGDPHPHPHPPHPVSGNGEVMLAGCAALGIEARVGPVAIANGRFGDRPHCIYRGFCLQGCKVNAKASPLITHVPDAIVHGAEIRPDSMVTRVETDREGRRVTGVRYVRGGRERFQRAAAVAVAGYSIETPRLLLNSANARFPEGLCNDHDLVGRYVMVQGAPQTAGRFAEEIRMYKGPPPEVSSEDFYETDPAKPYRRGFSVQTVSPLPIMWAEHVAAQGHWGADLRRRMADYTHWATLGALCEFLPQADNRVTLADETDRHGLPVARFDHSHCPNDGLLLEAAREVMERILKAAGATELMTVERYAHLVGGCRMGRTPQEGVVDGDLRSFAIPNLFVTDGSVLPTQGSANPALTIMALADRAATRLIARGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLL3</accession>
    <name>A0A2G1XLL3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52135">
        <property type="protein sequence ID" value="PHQ52135"/>
        <property type="gene ID" value="BLA24_09450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="346" mass="35972" checksum="544DEBB438A0B8A2" modified="2018-01-31" version="1">MAGRPDALRPGSSSPARTGPSRPTPRAPHERQVTVIAALIVATLALFPPTAWLLAARRKALTPTVPGTPAAEPELLEVALLTGGRTRLAETVITKMHGDERIEVNAAGRVRVHRAVSHHPMERALLGRCGADWNTSLRRLRTTLPYDPAADAVERSLAERGLLMSPRAKDRWRLAAGTQTAGLVVAFAAAVVLLFLPDSYPAPFVVLALAAGGVVLRVKCRPDLKVLQPTPAGEEFTRALGRQGPWSTRNPATHPEGAAGVVAVSGVGALDDGVLRQQLLKAARSQTRTRTRTSRTARRTAGSTTAASSSAACGGSSYSSCSSSSSCSSSSSSCSSSSCGGSSCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLN9</accession>
    <name>A0A2G1XLN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_09630</name>
        <name evidence="6" type="ORF">CYQ11_28240</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52184">
        <property type="protein sequence ID" value="PHQ52184"/>
        <property type="gene ID" value="BLA24_09630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16850">
        <property type="protein sequence ID" value="PPT16850"/>
        <property type="gene ID" value="CYQ11_28240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="85" mass="9289" checksum="521906D415F7153B" modified="2018-01-31" version="1">MTPAARAPESIGAWLVERVAHYVQLPVEEIDPDASPLEYGLDSLYAVVLCGDIEDTWGLAVEPDLVWEADTLAVLGARLADLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR6</accession>
    <name>A0A2G1XLR6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09540</name>
        <name evidence="3" type="ORF">CYQ11_28150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52150">
        <property type="protein sequence ID" value="PHQ52150"/>
        <property type="gene ID" value="BLA24_09540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16231">
        <property type="protein sequence ID" value="PPT16231"/>
        <property type="gene ID" value="CYQ11_28150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="380" mass="40974" checksum="DF2D1A7DE2AA172E" modified="2018-01-31" version="1">MTTTLDRATPADIADLRQLYYAVYGPHYPTALGTDPAEMSRLIADPHTLWLVARCTRTGGLAGSAAVHGEPGSRIGRLEGLAVHPEHRAGGLAGALTDELCRRTLGEGRLDSVYATVRTVSAGPQRVVSRNGFRPMGVLPNAVDLSSRESLALYARHSPGVLDRRVPVPEVPAPLVPLLRTAERTLGVDYAHTRATAPLAAPGAPPAGRLEMIEAPGFVRRRFHERFPDAGQWFYPLHTPNALLVADDGRFEVYAYLNRTGRYCALVAAHPGPAAAADYLEPITRTLTRAGTGYVEALLPLAQHGLLSAFLAQGFIPSALYPAMRPETDGDGFHDYVVMTRTAEQIDFRGVVVDAPLQPYLDAYVSAWAATYLPTLEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLT1</accession>
    <name>A0A2G1XLT1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_08640</name>
        <name evidence="12" type="ORF">CYQ11_03895</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52224">
        <property type="protein sequence ID" value="PHQ52224"/>
        <property type="gene ID" value="BLA24_08640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12157">
        <property type="protein sequence ID" value="PPT12157"/>
        <property type="gene ID" value="CYQ11_03895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="56"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="376"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="410"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ52224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="633" mass="67809" checksum="D870DA1AAFE914FD" modified="2018-01-31" version="1">MAAAPRPGRRGRGRAGGGRVPVNPRSRLRRLAQAPRPGLKVLGQSWRSDRAGTAQVIVTSLVVGVLPACQVTLTAAFATALLRAAGSSRPQAGDILFYLGLLALLGLGSQVLILLQSRAMQRCQSRLSAHLSDEIISRAGRFTLSQVEDPKIQDSLQRAVREVGFRPGMLLSQLVQTVTQVVAFGSVGAILWTLDYRVALLAVLAPVPTVVAQILQGKRAHALEHGRSEERRRLTYWQHLASQPDSMKEVLAFRLAPVVLTHHRKLLAGIVGADLRLANRNFRLAIPMVVLTAALTVSAQATAILAGTDARHVAGLLAVIQAIGMLQSSAQMLYGALSGMYVNQLFLRNVNEFLAIEHTPLPEGELAFPEEISAGVEFRDVSFSYPGSGRHALENVSFTLKPGQVTAVVGLNGAGKSTLGKLLGRLYEPTGGSIVVDGVPLADFRLDSLRDRVSYVFQNYVQYQLSVGENISLGLVHEADRAAGRVEAAAREVGMHEHIAALPQGYGTQAGKLFTGGVEFSGGQWQRLAIARSMVRSASVRVMDEPTAALDTITEAELLDTLTTATAGRVSLLIAHRFSSVLRADRVLVFDRGRLVEDGDHQELMGLGGLYARMYEAQTAGHEPAAGAATGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLT7</accession>
    <name>A0A2G1XLT7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000095">
        <property type="protein sequence ID" value="PHQ52193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52193">
        <property type="protein sequence ID" value="PHQ52193"/>
        <property type="gene ID" value="BLA24_09020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4142" evidence="2">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="321" mass="35672" checksum="87F551C1F65F655E" modified="2018-01-31" version="1">MTGPAGLRAPPMTPRQAGAPPRCSVGWTGRPRPAVARPARGIHLLREGRRLVRPRRPSPRRTPRTPAAEEKRSSEDANATPGHDSGGGPRPGRSDGPRHGARRPRRRPCGRQGRRRAHQAPPGRHGGGRRGRDARRHAVARCVKDAGRVLVRDHTRMDEQVRKVASRLRVSLPTTTTAEQRKQLKDLRAKARTADYDRLWVKTYGTAHVKTLALLDDEIAHGKNNDVRELARKLRPVVQSHLKMLFQCGAGGHGGRKDQGDQQGGDNGREHGQGNGQGQGRDTGRDNGRDQGRDRTHASSRDHGRTHDRHHRDRHDGHHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLU6</accession>
    <name>A0A2G1XLU6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000096">
        <property type="protein sequence ID" value="PHQ52186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52186">
        <property type="protein sequence ID" value="PHQ52186"/>
        <property type="gene ID" value="BLA24_09045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="64" mass="7042" checksum="E577B53C9407D4C1" modified="2018-01-31" version="1">MPNDALMPIGVFAQRSGLTSSALRFYADSGLLPPCRGRPRSRDGYRLYSQRLTARSGVRGDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLX7</accession>
    <name>A0A2G1XLX7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08720</name>
        <name evidence="3" type="ORF">CYQ11_03980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52237">
        <property type="protein sequence ID" value="PHQ52237"/>
        <property type="gene ID" value="BLA24_08720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12170">
        <property type="protein sequence ID" value="PPT12170"/>
        <property type="gene ID" value="CYQ11_03980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RimK" evidence="1">
        <location>
            <begin position="122"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="279" mass="29859" checksum="2664501432E71549" modified="2018-01-31" version="1">MRICLLTPAPDHPLLADATALLKRRHQVESLDPATVTDFPARFPGPAALADVYLLKTRTPHALALARFLEERGAPVLNSAGSTELCQDRTAMAALALRAGLPFVATRTEPALARLALDGTPGPVVVKSRHSRRHDLVARVDDAGQLRALAGQWPDEPVVVQRFTPNDGWDHKLWVVAGRVFAGLRRSELAAPVLDKGTRSLALRELPDGWLDVVLRVGEVFALDVYGVDLLDDGGAPQIVDINAFPGIRGQAGAPEALADLALRTAAGSHRPRVLPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY8</accession>
    <name>A0A2G1XLY8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_09010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000095">
        <property type="protein sequence ID" value="PHQ52191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52191">
        <property type="protein sequence ID" value="PHQ52191"/>
        <property type="gene ID" value="BLA24_09010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="138" mass="14066" checksum="0FA5CFF48FDEE6C3" modified="2018-01-31" version="1">MTRSHQTPLFVTGRGPPGPAVRHGREHDDEHPTLLKRHRRTPANAALALALAIAGVGLWAPSATADPVSVGYTCTGPGAPDGVQSLQVTVTAPATVAQGGTAELTLEVATELKVPFGIPAQSVTGELDLQLAARAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM99</accession>
    <name>A0A2G1XM99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52394">
        <property type="protein sequence ID" value="PHQ52394"/>
        <property type="gene ID" value="BLA24_08095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="66" mass="7271" checksum="CD2C1906D45311CD" modified="2018-01-31" version="1">MWHHVRKDLQQQALYLVWAHGHLEVEAEATRIQRFANVFPGVAGSTTAGVLAAPGLGALLRRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMA7</accession>
    <name>A0A2G1XMA7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_08920</name>
        <name evidence="6" type="ORF">CYQ11_04175</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52269">
        <property type="protein sequence ID" value="PHQ52269"/>
        <property type="gene ID" value="BLA24_08920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12201">
        <property type="protein sequence ID" value="PPT12201"/>
        <property type="gene ID" value="CYQ11_04175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="623"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="670"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="858"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="903"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="940"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1169"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1284" mass="136675" checksum="79B146A56334C6F0" modified="2018-01-31" version="1">MSEPGDPQSGDEEARQHAAAPGSARIYQAGRDQHIAERDLHLHYQDGVRRARRTAPGTRHGECPYPGLAAFTADQERWFFGRDAMTADLLIRLDERLNGGGPLMVVAPSGAGKSSLLRAGLLPALARGALPAAGSADWPRVLFTPTAHPMTALASSLAEATGVGPQELISALATSPQACVALLRRPPRGPSGGSSQAVRRMVLVIDQLEEAFTLCHSARERRDFLDVLTALAQPCPDGTAPVALVVFGLRADFYAPCADYPQLRTALQNGQIVVGPMTEGDLREAILFPAAAAGLQVEPGLVELLLRDLGAHAQRTTANTPVGQELPGAYDAGRLPLLAHALRATWQQRHGSTLTVDGYQATGGIRHAIATTAESLFTTLDAPGQAAARTLFLRMVMVGDRCEDTRRPASYTDLFIAGGQSRTTAAVIDTFTRGRLLTRQQDTVEISHEALLHAWPRLHRWINTDRAGHITHQNLEQAATEWEHAHRDTDLLYRGTRLETALAWADRAHQDDITTTTGAFLAASTRHERRAARLRRSVIAILAALALIASAAAVIAFQQRATATAQRGTAVFNQVKAQADRLRDSQSSLAAQLDLAAHRMRPDDPDVRTRLIDDANSPLSRPLPGAAGPFNAMVFSPDGRLLAGGRDDGTLQLWRFSDAAHAEPVGHVTSSSRGGPVFSVAFSHHGSLLATANNDGAVRLFDISDPTHPRLLGHTPLTSAATGPAAFSMAFSPDDKTMASASNNKWAQLWDISDPRRPTARGRTPASSQSGFVTAVAFSPNGHTLASRTDEGLQLWDTRNPAAPVSLGYAAGGIAGDNGNVVAFSPDGHTVAAGSADGTVQMWDVSQALHPTSLGRPLIGHLSEVTAVAFSSDGKTLASASTDHTVRLWKLADPAAVKPQERLTGHVTDVRTVAFAPSGSTLVTAGTDKAAQLWDLGHNVLTRDTSITTQAFSPDSQTMTTASQDGVIRRWNISDSNHPALLDSARLSANPDRVTLSPDSHTVAIVDSNHSDIRLWNVTDLRSPKLIGAAPGTSDTKLFFVWMAFSPNGHTFAASDQTGPWLWEITGSAHITLVHRQIAGAGEYGVRELAFSPNGHLLAGLQDGDEGGVRLWRITDPAHPEQLGHAPVRSGLTMAFSPDGNYIATGGEDGTISLWKIADPGRPAATSTFSARTGSVGTIAFSPDGHALTTGGADGAIRLWNVSAPSRPVAFGQPLTSHTGEVSLVAFSPTGRTLFSTGMDGTVRLWDTDINRTIARICDVTKTTLNRQQWQERLPGLPFNPPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMN8</accession>
    <name>A0A2G1XMN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52409">
        <property type="protein sequence ID" value="PHQ52409"/>
        <property type="gene ID" value="BLA24_07660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="413" mass="45383" checksum="66258E97EDA3EDEF" modified="2018-01-31" version="1">MVQVGCWAVELESVFARVAGRFGRADLRWRMRDYVRGLLGQAARKNGWQLAEWAGHRTPDGFQRLLNSSVWDADALRDDVRAYAGESLGPGGVLILDDTGFIKKGTTSAGVGRQYTGTSGKSDNCQIGVFAAYATSSGRALVDRELYLPKAWTSDCDRCRAAKIPDERGFATKGELARDIVRRCITAGLPASWVTADEAYGQDWHFRRLLEQLDLGYVVAVPKSQQIKSLAGIWRIDQLIEEAPGGAWQRLSCGDGAKGPRVYDWAAAKLPTNLIFAPDPPTHHRWVMARRSLSDPGELPYYLAYAPVGIELAELVRIAGSRWAIEECFQAAKNECGLDEYEVRRYIGWYRHITLAMLAHAFLAALAAQAGDAAKGAAETDQPSSLSPWQKSGDSWTLSCPTHEPTATPSPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMV1</accession>
    <name>A0A2G1XMV1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07255</name>
        <name evidence="3" type="ORF">CYQ11_27410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52558">
        <property type="protein sequence ID" value="PHQ52558"/>
        <property type="gene ID" value="BLA24_07255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16096">
        <property type="protein sequence ID" value="PPT16096"/>
        <property type="gene ID" value="CYQ11_27410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="291" mass="30616" checksum="276B2ACC9E7329CD" modified="2018-01-31" version="1">MSKQSVTVVGLGPMGQAMVRAFLAAGHQVTVWNRTAARAEELVAEGARRADTIGEALAANELVILSLTDYDAMYTVLGPAAEALAGRVLVNLSSDTPEKAREAARWAARHGARHLTGGVQSPPSGIGKPESATFYSGPRDAFEAHAATLGVLTGTDYRGEDPGLAALYYQIQMDVFWTAMLSYLHALAVADANGISAQEFLPYATSTVASLPGFLEFYAPRIDKGEHAGDVDKLAMGVASVDHVLHTTKDSGVDTSLPAAVRDVFRRGLAAGHAGDSFTSLIEVFKKEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN33</accession>
    <name>A0A2G1XN33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07250</name>
        <name evidence="3" type="ORF">CYQ11_27405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52626">
        <property type="protein sequence ID" value="PHQ52626"/>
        <property type="gene ID" value="BLA24_07250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16835">
        <property type="protein sequence ID" value="PPT16835"/>
        <property type="gene ID" value="CYQ11_27405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="19217" checksum="D0520A51FFFF58AC" modified="2018-01-31" version="1">MQRQGYDGTGIKQIAQEAKATLGSVYHFFPGGKQELAVAAVRHGDEEFVEILREVLASETDPAEAMIACTRALADGLRDSDWADGCPVTATALGTAHRAPDIQQAAAEAFERWRGLVAEKLHGAGIDEADARDLGHTVISTLEGAELAAQVSRSDEPLRIAGTHLARLIDSYRPADAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN92</accession>
    <name>A0A2G1XN92_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06260</name>
        <name evidence="3" type="ORF">BLA24_06285</name>
        <name evidence="1" type="ORF">BLA24_12430</name>
        <name evidence="4" type="ORF">CYQ11_04295</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000139">
        <property type="protein sequence ID" value="PHQ51669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000075">
        <property type="protein sequence ID" value="PHQ52649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000075">
        <property type="protein sequence ID" value="PHQ52651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51669">
        <property type="protein sequence ID" value="PHQ51669"/>
        <property type="gene ID" value="BLA24_12430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52649">
        <property type="protein sequence ID" value="PHQ52649"/>
        <property type="gene ID" value="BLA24_06260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52651">
        <property type="protein sequence ID" value="PHQ52651"/>
        <property type="gene ID" value="BLA24_06285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12221">
        <property type="protein sequence ID" value="PPT12221"/>
        <property type="gene ID" value="CYQ11_04295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="65" mass="6990" checksum="54FDF1DEFB6176D9" modified="2018-01-31" version="1">MDGVSTYLALTFGTLLSSQGTDASFVLTLSGFPPGASLRCSTLYQAFSRSLTARLSLMHEDMRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNH0</accession>
    <name>A0A2G1XNH0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">APC family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05700</name>
        <name evidence="3" type="ORF">CYQ11_02175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52760">
        <property type="protein sequence ID" value="PHQ52760"/>
        <property type="gene ID" value="BLA24_05700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11861">
        <property type="protein sequence ID" value="PPT11861"/>
        <property type="gene ID" value="CYQ11_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="648" mass="70473" checksum="C481C917C77DAB83" modified="2018-01-31" version="1">MATPTDTPTSRLRGWMLEGLSDMGRGRPSQAAPAPEHKGQPWYRVMCLTGVDYFSTLGYQPGIAALAAGLLSPVATIVLVIVTLAGALPVYRRVAEESPHGEGSIAMLSRLLSFWKGKLFVLTLLGFAATDFLITITLSAADASTHLVENPNLEGALHDKQVLITLILIALLGAVFLKGFLEAIGVAVVLVTVYLALNAVVVVTGLWHVLTEGHVVTDWTAALTAEHGNVFVMVGVALIVFPKLALGLSGFETGVAVMPHVKGAPDDTEDRPAGRTRGTKKLLTTAALIMSVFLILTSFITTVLIPHQEFESGGDASGRALAYLAHEYLGNAFGTVYDVSTILILWFAGASAMAGLLNLMPRYLPKYGMAPHWARAVRPMVIVFTLVAFLVTWIFDADVEAQGGAYATGVLVLICSAAIAVTIAARKAGQRGWTIGFGVISAVFLYTTVVNVIERPDGVKIGACFTAGILLVSLLSRLGRAFELRVTHVELDEMAERFIRDISQRTPRFIANEPDERDVTEYREKIEQIRADNDIPTTEDFVFVEVTVTDPSEFEAGLTVRGEIMHDRYRVLTMESSSVPNALAAFLLHARDLTGTRPHVFFEWTEGNPFTNFVRFFLFGQGEVAPVTREILREAEPDRDRRPRVHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW8</accession>
    <name>A0A2G1XNW8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05010</name>
        <name evidence="2" type="ORF">BLA24_08290</name>
        <name evidence="4" type="ORF">CYQ11_28520</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000087">
        <property type="protein sequence ID" value="PHQ52315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52315">
        <property type="protein sequence ID" value="PHQ52315"/>
        <property type="gene ID" value="BLA24_08290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52916">
        <property type="protein sequence ID" value="PHQ52916"/>
        <property type="gene ID" value="BLA24_05010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11423">
        <property type="protein sequence ID" value="PPT11423"/>
        <property type="gene ID" value="CYQ11_28520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="348" mass="37764" checksum="75F807A17CF81554" modified="2018-01-31" version="1">MDAVEAAVEKIARTCLYEGYLLWPYRRSALKNTRRWTFGGVFPHGRAAELGEPSRMRTEVLLASDGTAEVFVRLRFLHVVERQVHRLGPGGSEPVDALTVAGRRYLTWHEATERAWTLAPFRPADGPRSTTVAVPGGTAEEPLDDGDGRRAGVLVRSWRPLEGVVELDAVPLPGDVWRVAVTLTNTTACPPPPDPRTARDALAAHGFMSTHTVLRCSEGAAFVSLADPPAPLRGAADSCRNEGTWPVLVGRPAGDRQRARSVLSSPVTLEDFPAVAPESPGDLFDGGEIDQLLILSVLSLTPREQEEARASDPRAREILDRCAALSADELMALHGTIREFRPPKEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP60</accession>
    <name>A0A2G1XP60_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="9" type="ORF">BLA24_04175</name>
        <name evidence="10" type="ORF">CYQ11_14085</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53022">
        <property type="protein sequence ID" value="PHQ53022"/>
        <property type="gene ID" value="BLA24_04175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13870">
        <property type="protein sequence ID" value="PPT13870"/>
        <property type="gene ID" value="CYQ11_14085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="89"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="26850" checksum="C5575DA26BF81D30" modified="2018-01-31" version="1">MATGRTHRPATRSRGIPEATVARLPLYLRALTALSERSVPTVSSEELAAAAGVNSAKLRKDFSYLGSYGTRGVGYDVEYLVYQISRELGLTQDWPVVIVGIGNLGAALANYGGFASRGFRVAALIDADPAMAGKPVAGLPVRHTDELESIITDNGVSIGVIATPAGAAQQVCDRLVAAGVTSILNFAPTVLSVPEGVDVRKVDLSIELQILAFHEQRKAGEETTQPAATPSRPGAHARAAAGAGSRKGPDGDVPAVMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPY2</accession>
    <name>A0A2G1XPY2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_03095</name>
        <name evidence="3" type="ORF">CYQ11_05395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53305">
        <property type="protein sequence ID" value="PHQ53305"/>
        <property type="gene ID" value="BLA24_03095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12402">
        <property type="protein sequence ID" value="PPT12402"/>
        <property type="gene ID" value="CYQ11_05395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="24197" checksum="ECE0AF9B358B9C00" modified="2018-01-31" version="1">MTSTFPDISISTDRLVLRPFEAGDVPALAEMMNDELTTAWTSAPHPYTTADARDWVLRQAPAERTSGRGIVFAVTEFLTHRLVGIVHLRNTDWRTFSTEVAYVTAPWARGEGYACESVLAVAQWLFHDQRFERLELRTAADNTASQQVAQKIGCISEGVLRSAWIARSRTEDGGWTELRTDLIVWSLLPEDLDEIREAPAGGYGCSDYATAFPDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPZ0</accession>
    <name>A0A2G1XPZ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_03110</name>
        <name evidence="9" type="ORF">CYQ11_05410</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53308">
        <property type="protein sequence ID" value="PHQ53308"/>
        <property type="gene ID" value="BLA24_03110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12405">
        <property type="protein sequence ID" value="PPT12405"/>
        <property type="gene ID" value="CYQ11_05410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="370" mass="39221" checksum="A298F93E335836D1" modified="2018-01-31" version="1">MPVSGRHQRRALDSDGIPVITTTGLTKVYRSRGREVTALDGVDLHVREGEVYGVVGQSGAGKSTLIRCVNLLERPTSGTVTVAGQDLTALAGRGQRANAALRQARSRIGMVFQHFNLLSSRTVQANVELPLEILGVSGKERGRKALELLDLVGLADKAKAYPTQLSGGQKQRVGIARALAGDPKVLLSDESTSALDPETTRSILTLLRDLNRQLGLTVLLITHEMEVVKTICDSAALMKGGRVVESGTVSELLATPGSELAAELFPVGGEPSGPGRTVVDVTFHGEAATQPVISQLSRTYNIDISILGAAMDTVAGKQVGRMRIELPGRFEENVVPIGFLREQGLQVDVADVRTAHDTASADAILKDGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ10</accession>
    <name>A0A2G1XQ10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_02630</name>
        <name evidence="6" type="ORF">CYQ11_04925</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53229">
        <property type="protein sequence ID" value="PHQ53229"/>
        <property type="gene ID" value="BLA24_02630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12321">
        <property type="protein sequence ID" value="PPT12321"/>
        <property type="gene ID" value="CYQ11_04925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="187"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="288" mass="30155" checksum="7CC806C6AE41D886" modified="2018-01-31" version="1">MTANSTAHRLTVLGAGVMGTNIATTTIGHGVPVVLVDIDPGSLEKARVNIARNLRHAQMMGALPAGRTPGKLITSLSPADGAEATAVVEAVTEAADLKYKVLAQISAAVRPGTPLITNTSGIPVDELAGAVERPGDVVGIHFMNPTYLIRLVEVVRGPRTAEATMEAVTDLLAAIERRAIVVSDSPGFVTSRLLHPMINDAARIVGEGVTTAESVDALMEGCLGHPTGPLRTGDLIGLDNLADSLWALHERTGNDSFRPCELLLDKVRSGDLGRKTGRGFFDYGEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ61</accession>
    <name>A0A2G1XQ61_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Divalent-cation tolerance protein CutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01585</name>
        <name evidence="4" type="ORF">BLA24_01600</name>
        <name evidence="2" type="ORF">BLA24_23920</name>
        <name evidence="5" type="ORF">CYQ11_22150</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000027">
        <property type="protein sequence ID" value="PHQ53376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000027">
        <property type="protein sequence ID" value="PHQ53377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49126">
        <property type="protein sequence ID" value="PHQ49126"/>
        <property type="gene ID" value="BLA24_23920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53376">
        <property type="protein sequence ID" value="PHQ53376"/>
        <property type="gene ID" value="BLA24_01585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53377">
        <property type="protein sequence ID" value="PHQ53377"/>
        <property type="gene ID" value="BLA24_01600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15226">
        <property type="protein sequence ID" value="PPT15226"/>
        <property type="gene ID" value="CYQ11_22150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="11945" checksum="DD166D811C453C0A" modified="2018-01-31" version="1">MPEPEYVTVMTTTDSEAAARHLAQSAVERRVAACAQIDGPVTSVYRWEGRIETAAEWRVLFKATAACYAVLEAHVTREHPYDVPEIIALPVVAGSDAYLAWLRQETAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQB6</accession>
    <name>A0A2G1XQB6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00425</name>
        <name evidence="3" type="ORF">CYQ11_07435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53435">
        <property type="protein sequence ID" value="PHQ53435"/>
        <property type="gene ID" value="BLA24_00425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12739">
        <property type="protein sequence ID" value="PPT12739"/>
        <property type="gene ID" value="CYQ11_07435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304943" evidence="1">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="221" mass="24632" checksum="B834C98A74F51CD5" modified="2018-01-31" version="1">MTRVHRLLALTLLAAAVVVGIAIAVSNVWEESGEPERPWAEGSVHGSWRSVFDGHGENIGRHDGLALSPRPAREPGETHAGLIVSTRQYEDVDFRAKVRTLAQLRTPEPNPWEVPWLVWAYNDPEHFYYITLKPNGWELGKRDPAYPGGQRFLATGAEHFPIGRTSDVRVAQRGARIEVSVDGRGLVGYADRERPYLKGNVGVYTEDARVLFTDLSVRAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQF8</accession>
    <name>A0A2G1XQF8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00670</name>
        <name evidence="4" type="ORF">CYQ11_07680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53478">
        <property type="protein sequence ID" value="PHQ53478"/>
        <property type="gene ID" value="BLA24_00670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12783">
        <property type="protein sequence ID" value="PPT12783"/>
        <property type="gene ID" value="CYQ11_07680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="38"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="24443" checksum="A68576A078486754" modified="2018-01-31" version="1">MAPAPSGLLPARAPSERNWHDGGTRSSCKEVSSVASPTTIVLFHSAYGLRPAVLAAAERLRAAGHEVHAPDLYEGRTAESVEDGMAIKDEIGREELLRRAVTAVAPLSDRGLVYAGFSLGGSIAQNLALADAKARGLLLLHGTSDLAEDAAVDELPVQLHVADPDPFEPHDWLNAWYLRMGRAGADVEVHRYHGAGHLFTDPGLPDYDEEAAEAAWRVALGFLEDVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQF9</accession>
    <name>A0A2G1XQF9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">BLA24_00645</name>
        <name evidence="8" type="ORF">CYQ11_07655</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53474">
        <property type="protein sequence ID" value="PHQ53474"/>
        <property type="gene ID" value="BLA24_00645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12779">
        <property type="protein sequence ID" value="PPT12779"/>
        <property type="gene ID" value="CYQ11_07655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ53474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="197" mass="21609" checksum="952AB64913D4F1FB" modified="2018-01-31" version="1">MSRVGRVERTTKETSVLVEIDLDGTGQVDVSTGVGFFDHMLDQLGRHGLFDLTVKTDGDLHIDTHHTIEDTALALGAAFRQALGDKVGIYRFGNCTVPLDESLAQVTVDLSGRPYLVHSEPENMAPMIGAYDTTMTRHILESFVAQAQIALHVHVPYGRNAHHIVECQFKALARALRYACERDTRAEGIIPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQI6</accession>
    <name>A0A2G1XQI6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_00825</name>
        <name evidence="7" type="ORF">CYQ11_07835</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53507">
        <property type="protein sequence ID" value="PHQ53507"/>
        <property type="gene ID" value="BLA24_00825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12812">
        <property type="protein sequence ID" value="PPT12812"/>
        <property type="gene ID" value="CYQ11_07835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="204" mass="22206" checksum="CC052F0B3FFE9CDD" modified="2018-01-31" version="1">MDSSSTRRQNTRRKLFEAAVTLIAEQGFSSTTVDEIAERAGVAKGTVYYNFASKTVLFEELLKHGIELLTAALQAAADESAERGGSRVDALDAMIRAGLDFITRYPSLTQLYVAELWRTNRAWQSTLMQVRQKAIAVIESVLREAVAAGELSGDIDVPLTASALFGMVLVAALDWQSFQPERSIDEVHSALSRLLQGRVGGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQL8</accession>
    <name>A0A2G1XQL8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00840</name>
        <name evidence="4" type="ORF">CYQ11_07850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53510">
        <property type="protein sequence ID" value="PHQ53510"/>
        <property type="gene ID" value="BLA24_00840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12815">
        <property type="protein sequence ID" value="PPT12815"/>
        <property type="gene ID" value="CYQ11_07850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="34470" checksum="9BF4AE53E58C480B" modified="2018-01-31" version="1">MGWTVLYIAFGVVALWLLGEVLLQYKARLRWRLLAFVGFLGVVAGVVIPSVAVIVVGAVAFAVGQTFVTLSFRRGFSRGWAIRRGEEGAAAEPGRGSGKGESRAAGKSRAEKSRSGRRRKGGDRAQRSAAGVTAPVSGPDAPPTAGAGEDDRTELMPSVPQQPTGESAQPAGYGGGYGADTNATGTDQDGFPAYGSYAAAQPAEAPAAPGGYAGQFDYGQGQYAAYSDPYIGNRPPSYEQYDAYGQQQAYPQQQYGTTAYPGDTYATPQQYDVDTPPGGVWVPQQRDTDHPAGQAPPPEQYPGQQQPPYPPQQPGQGFDEQRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQM1</accession>
    <name>A0A2G1XQM1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division protein FtsQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsQ</name>
        <name evidence="10" type="ORF">BLA24_00735</name>
        <name evidence="11" type="ORF">CYQ11_07745</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FtsQ/DivIB family. FtsQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53491">
        <property type="protein sequence ID" value="PHQ53491"/>
        <property type="gene ID" value="BLA24_00735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12796">
        <property type="protein sequence ID" value="PPT12796"/>
        <property type="gene ID" value="CYQ11_07745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00911">
        <property type="entry name" value="FtsQ_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="9">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ53491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="295" mass="31382" checksum="5DD844EAA772AE19" modified="2018-01-31" version="1">MAGPTTARRGGAKNAKSKSSKSSRSPKSPKASRPALLPSRSRRPGGKPRKGAPRGSGARSRRAGRRRLLLWAVLAALLGAGVCWVLYGSGWLCVTRVEVSGTTVLTADEVREAAEVPLGDPLASVDTDAIEERLRARLRRVETVDVERSWPHAIGLKVTERQPKALLEKAGKFIEIDGSGVRFATVDQAVRGVPRLVLETEDSPSTRRFGTERLEQEAVRVAAALPAAIRGQTLVIRVRSYDSITVELTGGRTVVWGSGERGEVKARTLTALLKAAGGAKRFDVSAPAAPAVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQQ2</accession>
    <name>A0A2G1XQQ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">BLA24_00650</name>
        <name evidence="12" type="ORF">CYQ11_07660</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53566">
        <property type="protein sequence ID" value="PHQ53566"/>
        <property type="gene ID" value="BLA24_00650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16415">
        <property type="protein sequence ID" value="PPT16415"/>
        <property type="gene ID" value="CYQ11_07660"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="214" mass="23028" checksum="AF4F3480AB52A8CD" modified="2018-01-31" version="1">MTAAAKKVVVLDYGFGNVRSAERALAHVGADVEITHDFEAAMAADGLLVPGVGAFAACMEGLRAVRGDWIVGRRLAGGRPVMGICVGMQILFGRGIEHGVETEGLDEWPGTVEPLKAPVVPHMGWNTVTPAEDSQLFAGLDAGTRYYFVHSYAVREWSLEVTNPHIRAPKVTWAEHGEPFVAAVENGPLWATQFHPEKSGDAGAQLLTNWIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQS1</accession>
    <name>A0A2G1XQS1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000007">
        <property type="protein sequence ID" value="PHQ53586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53586">
        <property type="protein sequence ID" value="PHQ53586"/>
        <property type="gene ID" value="BLA24_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="121" mass="13710" checksum="6DED4FFCB6D36DDE" modified="2018-01-31" version="1">MLTYKQPVDHRTRRRDVRQRFTLLHKSVDRPTVFYTSVTTSTPSPAAASRPDRRRQPAVAGVPLLHPVPPQPADWSKLDIWQRPRPAPLYQPSSPSTQELAGHRAARRMTPPITAVTTRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X955</accession>
    <name>A0A2G1X955_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30225</name>
        <name evidence="2" type="ORF">CYQ11_23315</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47792">
        <property type="protein sequence ID" value="PHQ47792"/>
        <property type="gene ID" value="BLA24_30225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15417">
        <property type="protein sequence ID" value="PPT15417"/>
        <property type="gene ID" value="CYQ11_23315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="70" mass="8143" checksum="DD4A45A2B24A9CC7" modified="2018-01-31" version="1">MREHPVIRFTNELMMVSDLDQATAGAFVRSVFQEGIHEGEQRVIVEVHRRDRTIAELERELARLRGEPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9U1</accession>
    <name>A0A2G1X9U1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_31115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47939">
        <property type="protein sequence ID" value="PHQ47939"/>
        <property type="gene ID" value="BLA24_31115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1401"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ47939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="2149" mass="223804" checksum="432545B289D95A18" modified="2018-01-31" version="1">MSNDEKVLAYLKKLTTDLRQTRQRLSDVEAKSREPIAIIGMSCRFPGGVASPEDLWRLADSSVDAVGGFPADRGWDLDGVYDPDPDRAGRSYAREGAFVHDVADFDPGLFGISPREALAMDPQQRLLLEASWEVFERAGIRAADVRGSRTGVFAGLMYSDYVSRLPSVPDELEGYVGIGSAASVASGRVSYTFGLEGPAVTVDTACSSSLVALHLAVQALRNGECSLALAGGVTVMATPGTFVQFSRQRGLAADGRCKSFAAGADGTGWGEGVGMLLVERLSDAVRNGHKVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLAAADVDAVEAHGTGTTLGDPIEAQALLATYGQDREQPLLLGSIKSNIGHTQAAAGVAGVIKMVMAMQHGVLPQTLHVDEPSPHVDWTAGAVELLTKRTEWPGADRPRRAGVSAFGVSGTNAHVVLEQVAAADGPEGGSVAERVALPAVPWVLSGEGEAALRAQADRLKSFVQADPELDPADVGWSLVSTRTALSHRAVVVGTDRDELLAGLDALAAGVPVAGGLGVLFTGQGSQRLGMGRELYDAYPAFAAAWDDVCAELNRHLDRPLTDVVWGDDAELLGETLYTQTGLFALEVSLFHLVSSWGVKPDYLLGHSIGELAAAYVAGVWSLEDAARVVTARGRLMQALPTGGAMASIAAPENDVLPLLTDDVAIAAVNGPESVVLSGDEDAVQAIVDTLSGQGVKARRLRVSHAFHSPRMDAMLDDFATVLDDVTFHAPTLPVVSNLTGTLADEEMRTPHYWVRHVRETVRFADGLASLRELGVGTFLELGPDGSLTSLADGDGVPALRPGRPEATAVTTALGNLHVRGLDVDWTAVFPGTHPRVELPTYAFQRERFWLESGADAEAATSAVDAAFWDAVERGDVEALGVDAAQPLSEVLPALSSWRRAWRDQSVVDAWRYRYGWTPVAGLPTQPGLRGTWWVVGDAGDDVAAALTAAGADVHTVTTATEINGDTGTVTGVVSLLPAAETVSLVQTLGTAAIDAPLWCVTRGAVAVTDDDTVDPDQTTLWGLGRVIALEHPDRWGGLIDLPTELDEQTAATLCAVLGGTTTEDQLAVRGTRVWAGRLRRAATEGNAPGVWRTGGTALVTGGTGALGGHVARWLAGSGAEHIVLTGRRGADAPGAAELVAELEALGARARVEACDVADRDAVAALLGTIPDLRVVVHAAGVPSWGAVDDLSADAFESGTRAKVAGATHLDELTRDVDLDAFVLFSSIAGVWGSGNQSAYAAANAFLDGLAHRRRADGLAATSVAWGVWDGEGMAAQGADLLAGHGVLAMAPGLAVSALRQALLGDETAVVVADVDWARFGPRFTALRPSPLLSELLADVTEPAAPTGAFALRLRALSEAERTRAAVELVRTAAAAVLGHPGPEAVDAARTFQEIGFDSLTAVELRNRLTTATGIRPPATVIFDYPTPLALAAYLVSEVLGAAQEIVPATSATAPADDDPIVIVGMSCRFPGGVDSPEDLWRLVDTDGDAVSPFPTDRGWDLNGLYDPAPGRPGTSYTRVGGFVHGAGDFDPAFFGISPREALAMDPQQRLLLHTTWEAFERAGIPAADVRGSRTGVFVGASSQGYGAASASEGYFLTGSSSSVISGRVSYTFGLEGPAVTVDTACSSSLVALHLAVQALRSGECTLALAGGVTIMATPTAFVEFSRQRGLAADGRCKSFAAAADGTGWAEGVGMLLVERLSDAVRNGHKVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLGTADVDAVEAHGTGTTLGDPIEAQALLATYGQDREQPLLLGSIKSNIGHTQAAAGVAGVIKMVMAMQHGVLPQTLHVDEPSPHVDWTAGSVELLTERTEWPETGAPRRAGVSSFGVSGTNAHVILEQPSEVAEPVADRAELPAVPWVLSGEGEAALRAQADRLKTFVQADPELDPADVGWSLVSTRAALSHRAVVVGTNRDELLTGLENLTAGVPVTGALGVLFTGQGSQRLGMGRELYDAYPAFAAAWDEVCTQLNRHLDRPLTDVVWGEDAELLGETLYTQTGLFALEVALFHLVSSWGVKPDYLLGHSIGELAAAYVAGVWSLDDAAKIVTARGRLMQALPTGGAMASIAAPESDVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9X0</accession>
    <name>A0A2G1X9X0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ORF">BLA24_31660</name>
        <name evidence="16" type="ORF">CYQ11_24715</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48013">
        <property type="protein sequence ID" value="PHQ48013"/>
        <property type="gene ID" value="BLA24_31660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15639">
        <property type="protein sequence ID" value="PPT15639"/>
        <property type="gene ID" value="CYQ11_24715"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="115"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ48013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT15639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="464" mass="47961" checksum="3EC381C7D5CBCDCF" modified="2018-01-31" version="1">MAPAVPTTMDRPHFIGIGGAGMSGIAKILAQRGARVAGSDAKESATAEALRALGATVHIGHAADHLDEDATCVVVSSAIRADNPELAAAAERGVPVVHRSDALARLMDGLRPIAVAGTHGKTTTTSMLAVSLAALGLDPSYAIGGDLDGPGSNARHGGGDIFVAEADESDRSFHKYAPEVAIILNVELDHHANYASMDEIYESFETFVGRVRPGGTLVVSADQAGARELTERVSGRHDIEIVTYGAAEDADVRVLKVTPRGLASEVTVLLNGKMLTFAVSVPGSHYAHNAVAALAAGVALGIPAHNLASALGKYTGVKRRLQLKGEANGVQVIDSYAHHPTEMTADLEAIRGAAAGSRVLVVFQPHLFSRTQELGTEMGQSLALADASVVLDIYPAREDPIPGVTSDLIIDAAKEAGADVRPEHAMAAVPDVIAGMARPGDLVLTMGAGDVTDLGPKILARLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAB7</accession>
    <name>A0A2G1XAB7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32670</name>
        <name evidence="4" type="ORF">CYQ11_25720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48178">
        <property type="protein sequence ID" value="PHQ48178"/>
        <property type="gene ID" value="BLA24_32670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15804">
        <property type="protein sequence ID" value="PPT15804"/>
        <property type="gene ID" value="CYQ11_25720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="60"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="286" mass="31278" checksum="B5C6DB1A19815F3B" modified="2018-01-31" version="1">MPEAQGERTGNDGPGPDAPGGRAVYIHGHHESVLRSHGRRRAADSAAYLLPELRPDHRVLDIGCGPGSITADLAVLVPRGRVTGLDAAEGILGHARRAARERGVDNVDFTTGDVRALDFPDGSFDVVHAHQVLQYLDDPVAALREMRRVCRPGGIVAVRDVVYTAMTWYPRVPGLDDWQRLYVRVARAGGGEPDAGSRLLGWARQAGLTDVTTSAGAWCYAGEEQRAWWSGLWADRTLASPYARLAVEGGHADRAELERMARAWHEWGRHEDAWFAVLNGEVLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAE2</accession>
    <name>A0A2G1XAE2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_32835</name>
        <name evidence="5" type="ORF">CYQ11_25885</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48207">
        <property type="protein sequence ID" value="PHQ48207"/>
        <property type="gene ID" value="BLA24_32835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15833">
        <property type="protein sequence ID" value="PPT15833"/>
        <property type="gene ID" value="CYQ11_25885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758378" evidence="2">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="318" mass="33233" checksum="8ED09092690D0BAC" modified="2018-01-31" version="1">MVPLAAAAAATLGLPTTAGAAGGSTAVESVRAMTWNICGEAGGTSPADAGYCPYRNEPQKKADAIAEVVRVRNLNVVMLQEVCSGPPVAGGATGPSQLDVILTALGPGWTSATALSERPDGRTNCRGALSGTLGTAILVKGTIDDRPEPVVLPVPLDTDADRSRVLCVGVAGWRTHLCTTHLANNDTLLKSGAYDAQVATLKRTISAYPRVVVGGDFNMGLYHHVIPAKLQPMYDLLTECDRTSYVAGDAADEVTHFTYASATGTYTSSKIDYLFSTAGFTGCDSWTQKADQADYRTTRQPTGVSDHAPLYGYTPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAF2</accession>
    <name>A0A2G1XAF2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32750</name>
        <name evidence="3" type="ORF">CYQ11_25800</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48192">
        <property type="protein sequence ID" value="PHQ48192"/>
        <property type="gene ID" value="BLA24_32750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15818">
        <property type="protein sequence ID" value="PPT15818"/>
        <property type="gene ID" value="CYQ11_25800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="13149" checksum="B435021788D64B8B" modified="2018-01-31" version="1">MNPYETAVARYFEAWNAGDADARAKAVAAAWVEDGTYTDPLAQVRGHDALAAVIGGAQEQFAGFEFRHTGSVDGHHDIARFSWELVSVSDGSAPVAGFDVITLAEDGRIRSVLGFLDRVPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAG7</accession>
    <name>A0A2G1XAG7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32990</name>
        <name evidence="4" type="ORF">CYQ11_26040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48234">
        <property type="protein sequence ID" value="PHQ48234"/>
        <property type="gene ID" value="BLA24_32990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15861">
        <property type="protein sequence ID" value="PPT15861"/>
        <property type="gene ID" value="CYQ11_26040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="171" mass="18521" checksum="77962333725294E3" modified="2018-01-31" version="1">MESHGSVPSEPRRTPPPRKPAEYDGTWRYTAPALDSSVPRARHAVRDLIRRERVPLREDLLQGLLLIVSELVTNAVQHAALLSPEVAVEVSLGPAWVRVAVEDSHPYRPRPTEAYAEDEPRTGGRGLLLVQATVAEAGGLCDVEHTAAGGKVIWAALPLCPPPATSPSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAH5</accession>
    <name>A0A2G1XAH5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_33000</name>
        <name evidence="9" type="ORF">CYQ11_26050</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48236">
        <property type="protein sequence ID" value="PHQ48236"/>
        <property type="gene ID" value="BLA24_33000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15863">
        <property type="protein sequence ID" value="PPT15863"/>
        <property type="gene ID" value="CYQ11_26050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="32911" checksum="E6A87974A41FD174" modified="2018-01-31" version="1">MGAGHDHGHSHGGPPPGTSGTAAAAYKGRLRVALGITLTVLLTYVAGSVLTGSLALFAEAGHMATDAVGVSMALLAIHFAGRPPSSRRTYGYARAEILAALLNCLLLLGVGGFILFEAVERLANPTDVPGGQAVVFGLVGVVANGISLALLMRGQKESLNVRGAFLEVLSDALGSLAVVIAALVIMVTGWTRADSVASLVIGLMIVPRTVKLLREALDVLLEAAPKDVDMDEVRAHIMALPGVEDLHDLHVWTITSGMPVLSAHVVVDPARLDSAGHEKMLHDLQGCLGEHFAVEHCTFQLEPSGHAEHEARLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAK2</accession>
    <name>A0A2G1XAK2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_33110</name>
        <name evidence="3" type="ORF">CYQ11_26160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48253">
        <property type="protein sequence ID" value="PHQ48253"/>
        <property type="gene ID" value="BLA24_33110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15883">
        <property type="protein sequence ID" value="PPT15883"/>
        <property type="gene ID" value="CYQ11_26160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="288" mass="32388" checksum="5937696B3FEDCE3A" modified="2018-01-31" version="1">MADARPAGAPTVLRVVLGKRLQDLREKAGLSYEEAGRALDVTHATVRRMEKAEVGLKIPYVEKLLRVYGVLDAEEVEGFLALAREANRPGWWHRFRDVLPEWFSAFVSLEGEANLIRAYEPHYVPGLLQTEDYARAVLRAGMPHAPEADVERAVAVRRQRQALLTRDRAPLLWVVMDETVLRRPIGGPEVMRAQLDRLVEATDLPHVRLQLMPFAAGPHPAMYGPFHIFRFPIRELPDIAYAENLVGASYFDQRDDVSAFLEALDRMCAQAAPAHTTKAILGGIRKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAS9</accession>
    <name>A0A2G1XAS9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_31265</name>
        <name evidence="3" type="ORF">CYQ11_24305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48338">
        <property type="protein sequence ID" value="PHQ48338"/>
        <property type="gene ID" value="BLA24_31265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16762">
        <property type="protein sequence ID" value="PPT16762"/>
        <property type="gene ID" value="CYQ11_24305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="127" mass="13574" checksum="2898DF4CC5F0CE53" modified="2018-01-31" version="1">MGGGGALELGALQRRLAAFAAAREWQPFHTPKNLAAALSVEASELVEIFQWLTPEESARVMDSPGTAGRVQDEVADVLAYLLQFCDVLGIDVLAALSTKIDRNERRFPVPGERGGGAPDEGDCHSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB18</accession>
    <name>A0A2G1XB18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_32730</name>
        <name evidence="6" type="ORF">CYQ11_25780</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48379">
        <property type="protein sequence ID" value="PHQ48379"/>
        <property type="gene ID" value="BLA24_32730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16805">
        <property type="protein sequence ID" value="PPT16805"/>
        <property type="gene ID" value="CYQ11_25780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="230" mass="25260" checksum="58E4B6C8B613780E" modified="2018-01-31" version="1">MVAIAAQERLRDKVAHALRAALISGELRPGCVYSAPALAADFGISATPVREAMLDLAREGLVEPIRNRGFLITEVSERDLDQFTEIRALIEIPTVGRVARTATRQQLEALRPVAEEIVDAARAHDLIGYLEADRRFHLALLSLAGNDHLVTFVGDLRKRSRLYGLTRLDERGELLPSAEEHLELLELALAGDAAGAEACMGRHLGKVRSLWAQARDEPVEPSRRPRLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB45</accession>
    <name>A0A2G1XB45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteinase inhibitor I78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29105</name>
        <name evidence="2" type="ORF">CYQ11_06370</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48435">
        <property type="protein sequence ID" value="PHQ48435"/>
        <property type="gene ID" value="BLA24_29105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12569">
        <property type="protein sequence ID" value="PPT12569"/>
        <property type="gene ID" value="CYQ11_06370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="71" mass="7784" checksum="AFA98F3AF6634E45" modified="2018-01-31" version="1">MAPLPNFPTDPDDDPAAYVGLAAETAARQARERGWTDVRALAPGAVITLEYRVGRLNFEVDEGVVRRSWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBI6</accession>
    <name>A0A2G1XBI6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29935</name>
        <name evidence="4" type="ORF">CYQ11_05535</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48570">
        <property type="protein sequence ID" value="PHQ48570"/>
        <property type="gene ID" value="BLA24_29935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12428">
        <property type="protein sequence ID" value="PPT12428"/>
        <property type="gene ID" value="CYQ11_05535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="481" mass="50780" checksum="49D45E9DDAA588CD" modified="2018-01-31" version="1">MHERSSVAELARILRNELDRYSPGEKLPSSRSLVDRFHASPVTVSRALACLAAEGLVVTRPGAGVFRSEPRHPLTRAGDTSWQQVALSAEAGEEAVPRSVDASGIVVTLVEPPPGVVELKGGYLSPALQPERALAAALGRAGRRPGAWGRPPVEGVGELRAWFAREIGGPAGTVAPSDVLITAGGQSALTAALRALAPPGAPVLVESPTYPGMLAAARAFGLRPVPVPTDARGVRPDLLRRAFQASGARVFVCQPLFQNPTGAVLADERRAEVLHAAREAGAFVIEDDFARRLAHEDAPPLPPTLVADDPDGIVVHACSLTKFTSPSMRVGALAARGPVLERLRAIQIVDSFFVPRPLQEAALELVGSPAWTRHRRTVAAELRVRREALMTALTRELPELVVESVPPGGFHVWARLPDGMDEDALTAAALRAGVAVTTGRPYYAAEPPAAHLRLGFASAAGAGELVDGVRRLRAAWDEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBJ1</accession>
    <name>A0A2G1XBJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-3' exonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Flap endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_29765</name>
        <name evidence="4" type="ORF">CYQ11_05710</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48603">
        <property type="protein sequence ID" value="PHQ48603"/>
        <property type="gene ID" value="BLA24_29765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12460">
        <property type="protein sequence ID" value="PPT12460"/>
        <property type="gene ID" value="CYQ11_05710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="32045" checksum="C5720587EA8F4394" modified="2018-01-31" version="1">MLLDTASLYFRAYFGVPESVKAPDGTPVNAVRGLLDFIARLVQDHHPDDLVACMDFDWRPQWRVELIPSYKAHRVADEVVGAPDEEETPDTLSPQVPVIESVLDALGIARVGAVGYEADDVIGTLAGRSAGPVDIVTGDRDLYQLVDDRRGVRVLYPVKGVGTLQVVDEAVLREKYGVDGPGYADLALLRGDPSDGLPGVPGIGEKTAAKLLASFGDLAGIMAAVDDPATKLSPAQRRRLDEARPYLAVAPKVVRVASDVPLAPFDAALPAAPRDAEALDALAGRWGLGGSLQRLLTALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBQ6</accession>
    <name>A0A2G1XBQ6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ORF">BLA24_28400</name>
        <name evidence="10" type="ORF">CYQ11_07070</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48640">
        <property type="protein sequence ID" value="PHQ48640"/>
        <property type="gene ID" value="BLA24_28400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12681">
        <property type="protein sequence ID" value="PPT12681"/>
        <property type="gene ID" value="CYQ11_07070"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="26973" checksum="0727465F5E0B8E14" modified="2018-01-31" version="1">MTTPQVVVHRDKELMAQAAAARLITKIVDAQAARGSASVVLTGGRNGNGLLAALAAAPARDAVDWSRLDLWWGDERFLPEGDPERNATQAREALLDAVDLDPARVHYMPAADGTHDDADAAAEAYAAELAAAARPEDHGPVPAFDVLLLGVGPDTHVASLFPELPGVRETERTVVGVHGAPKPPPTRVSLTLPAIRAAREVWLLAAGEDKAGAVAVALSGAGEVQAPAAGAYGRSRTLWLLDQAAAARLPRDLYPPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBR7</accession>
    <name>A0A2G1XBR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28690</name>
        <name evidence="4" type="ORF">CYQ11_06775</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48687">
        <property type="protein sequence ID" value="PHQ48687"/>
        <property type="gene ID" value="BLA24_28690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12632">
        <property type="protein sequence ID" value="PPT12632"/>
        <property type="gene ID" value="CYQ11_06775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="217"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="594" mass="66322" checksum="BEDBDFB5D2D398C6" modified="2018-01-31" version="1">MAALIEDYALIGDLQTAALVGRDGSVDWLCLPRFDSAACFAALLGDEDNGHWRLAPDGAGACTRRAYLKDSLALESVWETARGTVKVTDFMPQRDRAPDLVRIVEGVSGQVDMRSVLRLRFDYGDIVPWIRRTDGHRVAVAGPDSAWLRSEPPVPTYGRDYSTYSEFTVGAGEKVAFVLTWHPSHEPRPRLVDPHEALEHCLADWRAWADRCQYEGPHRDAVVRSLITLKALTYAPTGGIVAAPTTSLPEEIGGVRNWDYRYCWLRDSTLTLKALLSLGYEEEATAWRDWLLRAVAGKPSDLQIMYGLGGERRLPERELPWLAGYERSQPVRVGNGAVGQLQLDVYGEVIDSLHVARRGGLLAKPHAWNIQRHFLEFLQRHWREPDEGLWEIRGPRRHFVHSKVMAWVAADRAVRALEADPGLGGDVDAWRTMRDEVHREVCARGYDAERGTFTQYYGSRELDAAALLIPRVGFLPPDDPRVVGTVDAVRRELTCEGFVRRYSLEGRRVDGLPGDEGTFLVCSFWLADALYLTGRTKEARKLFEQLLTLRNDVGLLAEEYAPGAGRLLGNFPQAFSHIGLVGTALLLSGGDTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBV8</accession>
    <name>A0A2G1XBV8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000160">
        <property type="protein sequence ID" value="PHQ48744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48744">
        <property type="protein sequence ID" value="PHQ48744"/>
        <property type="gene ID" value="BLA24_28195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="359" mass="39443" checksum="21AD1E17E443D0CF" modified="2018-01-31" version="1" fragment="single">ADRHRQAAETLRRWQDEQVLAPDPEPALYVYEQRGEGILQRGLIGALRLSPREEGVVLPHEDVMPHIIEDRAALMRDTGANLEPLLFSYRGNGDGTEGAAGVIERVIRTEPLLSTTTDDGYAHRLWSVTDAADLALITEDLSHQHALIADGHHRWATYLRLRDEQPAPGPWDFGLVLLVDTARYPLRVRAIHRLLHRLPVADALAAVGGSFRVRALDGPLPEALDALAEAVREGGNAFVLAGDGRFHLLDRPDAGLLARTVPTDRPRAWRELDAAVLHSALLEHVWEVPDDPEHIGYIHEAAAAVAQAERHGGTAVLMHPVHEDVVRELAEQGVTMPRKSTSFGPKPATGLVLRSLALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBX1</accession>
    <name>A0A2G1XBX1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28890</name>
        <name evidence="2" type="ORF">CYQ11_06575</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48722">
        <property type="protein sequence ID" value="PHQ48722"/>
        <property type="gene ID" value="BLA24_28890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12598">
        <property type="protein sequence ID" value="PPT12598"/>
        <property type="gene ID" value="CYQ11_06575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="28513" checksum="442975324E3472CE" modified="2018-01-31" version="1">MVFKKLMASLGAGGASVETVLFEENVVPGGVVQGEVRIQGGSVPQRIEGLSVGLQARVEVEGDDGEYKQDVEFTRLQLGGAFEVQPGAVHSVPFGLEIPWETPITMFLGRHLTGMNVGVTTHLAIARAVDSSDLDPVNVHPLPAQQAILDAFGQLGFAFKSADLERGHIRGTRQRLPFYQEIEFHAPSQYRGLNEVELSFVADDREMDVVLEMDKKPGVFSSGSDAYRSFAVDLQAYAQTDWAAYLNQWLSEVGGKRNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBZ2</accession>
    <name>A0A2G1XBZ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Iron ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_28855</name>
        <name evidence="6" type="ORF">CYQ11_06610</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48742">
        <property type="protein sequence ID" value="PHQ48742"/>
        <property type="gene ID" value="BLA24_28855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16386">
        <property type="protein sequence ID" value="PPT16386"/>
        <property type="gene ID" value="CYQ11_06610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT16386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="28951" checksum="D603F0EEDD9551FF" modified="2018-01-31" version="1">MSDVLELVDVSVVREGRALVDQVSWSVKEGERWVILGPNGAGKTTLLNVASSYLFPTKGTARILGEKLGAVDVFELRPRIGMASIALADKLPRSQTVLQTVLTAAYGMTAGWQEDYEEVDEQRARAFLDVLGMTDYLDRKFGTLSEGERKRTLIARAMMTDPELLMLDEPAAGLDLGGREDLVRRLGRLARDPLAPSMIMVTHHVEEIAPGFTHVLMIRQGKVLAAGPLELELTSRNLSHCFGLPLVVERRGDRWSAQGLPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC09</accession>
    <name>A0A2G1XC09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28555</name>
        <name evidence="3" type="ORF">CYQ11_06910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48735">
        <property type="protein sequence ID" value="PHQ48735"/>
        <property type="gene ID" value="BLA24_28555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16393">
        <property type="protein sequence ID" value="PPT16393"/>
        <property type="gene ID" value="CYQ11_06910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="46"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="361" mass="38882" checksum="95F5D02E51D6F56A" modified="2018-01-31" version="1">MLHIKGRILVGPDPLSGVRDELWVVGGRITFDRPAGARDVTTVEGWVLPGLVDAHCHVGLDAHGAVDESTTEKQALTERGAGALLLRDAGSPSDTRWIDDREDLPRIIRAGRHIARTRRYIRNYAHEIEPEDLVAYVAREARRGDGWVKLVGDWIDRETGDLGVCWPRGEVEAAIAEAHRLGARVTAHCFAEETLAPLVEAGIDCVEHATGLTEETIPLFAERGVAIVPTLVNIATFPRLAAGGEAKFPRWADHMRRLHARRYETVGAAYDAGVPVYVGTDAGGSLPHGLVAQEVAELVTAGVPASAALAATAWGAREWLGRPGLEEGAPADLVVYDADPRADVRVLGAPRRVVLRGRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC33</accession>
    <name>A0A2G1XC33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27310</name>
        <name evidence="6" type="ORF">CYQ11_18345</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48786">
        <property type="protein sequence ID" value="PHQ48786"/>
        <property type="gene ID" value="BLA24_27310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14565">
        <property type="protein sequence ID" value="PPT14565"/>
        <property type="gene ID" value="CYQ11_18345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="230" mass="25059" checksum="C44648F10F4444FC" modified="2018-01-31" version="1">MTTETTGQAAERHVRVVLVDDHRMFRTGVQAEIGATDRTGVEVVGEAADVDQALTVITATRPEVVLLDVHLPGGGGVEVLRRSAAMMTDQNAPVRFLALSVSDAAEDVIGVIRGGARGYVTKNITGDDLVDAVFRVKDGDAVFSPRLAGFVLDAFASTDAPPVDEDLDRLTQREREVLRLIARGYAYKEIAKQLFISVKTVESHVSAVLRKLQLSNRHELTRWATARRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC43</accession>
    <name>A0A2G1XC43_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_27375</name>
        <name evidence="11" type="ORF">CYQ11_18270</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48796">
        <property type="protein sequence ID" value="PHQ48796"/>
        <property type="gene ID" value="BLA24_27375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14554">
        <property type="protein sequence ID" value="PPT14554"/>
        <property type="gene ID" value="CYQ11_18270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT14554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="521" mass="55969" checksum="FE6F8C5CF547DDCB" modified="2018-01-31" version="1">MGTYAAHGGLIAGRYRLGRKIGRGGMGTVWRATDELLAREVAVKELHMDEQQSAQEAQAQRDRMLREARAVALIKHPNVIVMHDIVEQDGRPWIVMELVDGRSLSSLLAAEGPITPREAARIGVAMLGALRAAHARGVLHRDIKPPNVLLESGTGRVVLTDFGIAQVSGATTITETGAFVGSPEYTAPERMSGGPAGPESDLWSLGVLLCTAMNGESPFHRDSLGGILHAVVYDEIRPPGTAGPLLPVVRGLLERDPAHRMSADEAERLLTGYLESRRAPVPVAYTPTRTDLPAGRRQTHEITRARSALLAAITIVALAGMGAGAAALLMDRGGTQADGRTPARSSTLNTPSAVPEPPASASVTAPPGYRSVQDPAGFALAVPEGFTRSFEPPRIFYYSPGKEFRIGVLIQDLQEGGPIGVMRSSAALAPDRYPGYRDGTVERAEHKGHRAAVWEFTWDGFEESENKAPQGSRHTYDIAWDEGEKMYDVWVSAPAGKAEEGRRYFDAAVSTFVRTKPVSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC95</accession>
    <name>A0A2G1XC95_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">murQ</name>
        <name evidence="5" type="ORF">BLA24_27895</name>
        <name evidence="6" type="ORF">CYQ11_17745</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48884">
        <property type="protein sequence ID" value="PHQ48884"/>
        <property type="gene ID" value="BLA24_27895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14468">
        <property type="protein sequence ID" value="PPT14468"/>
        <property type="gene ID" value="CYQ11_17745"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="66"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="311" mass="31519" checksum="9BB5F3BD005901DD" modified="2018-01-31" version="1">MTSTAAFAALRAQLATLTTEAFRPDLADIDRLPTQAIAKIMNAEDATVAAAVAERLPEIAAAIDATAARMARGGRLVYAGAGTAGRLGVLDASECPPTFNTDPTQVVGLIAGGPEALVAAVEGAEDSAELAAADLDALGTGPDDTVVGVSASGRTPYAVGAVRHARAAGALTIGLSCNARSELGAAAEHAVEVVVGPELLTGSTRLKAGTAQKLVLNMLSTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVSLATGAADDEIEAALTATDGEVKNAILVLLGEVDGPTATRLLAQSHGHLRAALRAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCF6</accession>
    <name>A0A2G1XCF6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27870</name>
        <name evidence="2" type="ORF">CYQ11_17770</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48881">
        <property type="protein sequence ID" value="PHQ48881"/>
        <property type="gene ID" value="BLA24_27870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14472">
        <property type="protein sequence ID" value="PPT14472"/>
        <property type="gene ID" value="CYQ11_17770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="229" mass="25773" checksum="50D418C2F62349D6" modified="2018-01-31" version="1">MAATPEPQHPRHEALHARWRETVRRVRTTPEPDSGPYADDLLARWSEPQRRYHTLDHLAAVLHHLDALAAHADDIDTVRLAAWFHDAVYRPDRSENEERSAHLAERALSELGVDPARTAEVTRLVRLTVSHDPAPGDRDGETLCDADLAVLGGAPEEYAAYAAAVREEYGFVPDAAFREGRADVLRRLLALPRLYRTPLGHDRWELLARRNLTTELELLTAATVGEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG6</accession>
    <name>A0A2G1XCG6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27335</name>
        <name evidence="7" type="ORF">CYQ11_18320</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48926">
        <property type="protein sequence ID" value="PHQ48926"/>
        <property type="gene ID" value="BLA24_27335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16648">
        <property type="protein sequence ID" value="PPT16648"/>
        <property type="gene ID" value="CYQ11_18320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="18526" checksum="4C7F3DF3CF7DDD57" modified="2018-01-31" version="1">MTLTGRGGTAEERRAALSRYALLPLRLFLGITFVYAGVDKLTDSAFLAAQGQGSLGELMRSVRDTAAIPGLVDLGLKSPVSFGYALALGELAVGLGTLFGAFARVAAAGGALISLTLWLTVSWPTTPYYYGNDLAYLMAWLPLILAGAPLLSVDAMWARGGRGRARRGRRGRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCL1</accession>
    <name>A0A2G1XCL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27985</name>
        <name evidence="5" type="ORF">CYQ11_17655</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48899">
        <property type="protein sequence ID" value="PHQ48899"/>
        <property type="gene ID" value="BLA24_27985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14452">
        <property type="protein sequence ID" value="PPT14452"/>
        <property type="gene ID" value="CYQ11_17655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="178"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="315" mass="32810" checksum="BD5C5C5C91263FE1" modified="2018-01-31" version="1">MTAGTNGTGTPENDDPFGYLYRSEGGDGATEGGQAVRQPGVPRTSYNQVRPVGSRQYGQQPAANRAQQHPHYAAPETLPGGMQAQPGHAAPAQGGHGSRPNRRGLLIAAIAVVAVVATGIGVAMMTNNSSDKGTTQNIADGEKSGGQGDADKSDDSSKKKDDKDKGDKPKSNSTNAQLKRDASTLRLSGGATTEKIVNGAQATDGLYITGMNQVGAAVEWTVDVDAGGDYRLNARYGVPGKDANLTISTNGKGDTRPISMKNFGGTKEGDWEAGWKNTWSIIKLNKGTNTIKVSCEPGNACEVHLDQLWLTKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCU0</accession>
    <name>A0A2G1XCU0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ORF">BLA24_23015</name>
        <name evidence="4" type="ORF">CYQ11_23060</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48979">
        <property type="protein sequence ID" value="PHQ48979"/>
        <property type="gene ID" value="BLA24_23015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15376">
        <property type="protein sequence ID" value="PPT15376"/>
        <property type="gene ID" value="CYQ11_23060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="155" mass="16569" checksum="05582C93B1E1ECEA" modified="2018-01-31" version="1">MADNARAKRLADLIREVIAQKLQRGIKDPRLGSHVTITDTRVTGDLREATVFYTVYGDDEERASAAAGLESAKGILRSEVGRAAGTKFTPTLTFVADALPDNARTIEDLLDRARASDAQVRQASSGATYAGEADPYRKPGEDDEATGTDKDAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD07</accession>
    <name>A0A2G1XD07_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23810</name>
        <name evidence="3" type="ORF">CYQ11_22260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49108">
        <property type="protein sequence ID" value="PHQ49108"/>
        <property type="gene ID" value="BLA24_23810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15244">
        <property type="protein sequence ID" value="PPT15244"/>
        <property type="gene ID" value="CYQ11_22260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="179" mass="18990" checksum="60C8D7ECDD00A94E" modified="2018-01-31" version="1">MNVTVFCSAADLDERYTGPAREFAALIGKGGHTLVWGGSESGLMKVMADGVQENGGRLVGVSVEFLAAKARKNADEMVVAKDLAERKAQLLARGDAVVVMVGGTGTLDEATEILELKKHGLHDKPVVLLNAAGFYDGLKQQFQRMEDEGFLPLPLTALVFFAEDAVGAMAYLEESAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD20</accession>
    <name>A0A2G1XD20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24035</name>
        <name evidence="3" type="ORF">CYQ11_22035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49144">
        <property type="protein sequence ID" value="PHQ49144"/>
        <property type="gene ID" value="BLA24_24035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15206">
        <property type="protein sequence ID" value="PPT15206"/>
        <property type="gene ID" value="CYQ11_22035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="96" mass="10101" checksum="7B0FA43D3530AD52" modified="2018-01-31" version="1">MTSAHTPPTPAPADPVPPAGCADVRVVASSPETARRVAEVLRHCFDSTEQRSYPAGREGGTRLHLTVDTAHPAEPARSWLATSRASAADRPPHGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD41</accession>
    <name>A0A2G1XD41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA carboxylase subunit beta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23630</name>
        <name evidence="4" type="ORF">CYQ11_22440</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49079">
        <property type="protein sequence ID" value="PHQ49079"/>
        <property type="gene ID" value="BLA24_23630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15275">
        <property type="protein sequence ID" value="PPT15275"/>
        <property type="gene ID" value="CYQ11_22440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="527" mass="57071" checksum="7168E487112E0EC4" modified="2018-01-31" version="1">MSNLEGAPVEASDVRGRVAELHAIREQVRRGPSERATQAQKAKGKLTARERIDLLLDEGSFTEVEPLRRHRASGFGLEEKRPYTDGVITGWGTVHGRTVFVYAHDFRIFGGALGEAHATKIHKIMDKAIAAGAPLVSLNDGAGARIQEGVSALAGYGGIFQRNTKASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVRAVTGEEITQNGLGGADVHAETSGVAHFAYDDEETCLEEVRYLLSLLPQNNRENPPRVAADDPADRAGEALLDLVPADGNRPYDMRKVIEEIVDDGEYLEVHERWATNIICALSRLDGQVVGIVANQPQSLAGVLDIEASEKAARFIQMCDAFNIPIITLLDVPGFLPGVDQEHGGIIRHGAKLLYAYCNATVPRISVILRKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVIFRKQIAEADDPEAMRARMVKEYKAELMHPYYAAERGLVDDVIDPVETRSVLIRSLAMLATKHADLPSRKHGNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD51</accession>
    <name>A0A2G1XD51_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23845</name>
        <name evidence="3" type="ORF">CYQ11_22225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49115">
        <property type="protein sequence ID" value="PHQ49115"/>
        <property type="gene ID" value="BLA24_23845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15237">
        <property type="protein sequence ID" value="PPT15237"/>
        <property type="gene ID" value="CYQ11_22225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="200" mass="21036" checksum="E81B4BCB6D23A56B" modified="2018-01-31" version="1">MDAKTTRPLDAASDPRPLYARAADQVAALVAAVPAGGLDAPTPCEGFDVRALLAHLVSGVRAGAALGETGRDTDLAPVTGVPDDGWAKAYDEARARLVAAWADDAKLDVPVVVPWGTMPGRAFLASGGVLETVAHTWDLSRALGDPLPLDQDLAEYALEWAHRALPAERRGEGVPFEPVRQAPEGADAYTRLAAWLGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD60</accession>
    <name>A0A2G1XD60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24225</name>
        <name evidence="3" type="ORF">CYQ11_21850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49176">
        <property type="protein sequence ID" value="PHQ49176"/>
        <property type="gene ID" value="BLA24_24225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15174">
        <property type="protein sequence ID" value="PPT15174"/>
        <property type="gene ID" value="CYQ11_21850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="20202" checksum="86DA9C542AAD9C42" modified="2018-01-31" version="1">MPKPLSLPFDPIARADELWKQRWGSVPAMAAITSIMRAQQILLGQVDAVVKPYGLTFARYEALVLLTFSRAGELPMSKIGERLMVHPTSVTNTVDRLVTAGLVAKRPNPNDGRGTLASITDKGREVVESATRDLMAMDFGLGVYDAEECGEIFRMLRPLRVAAEDFADERDEQGEPAGRDRADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD75</accession>
    <name>A0A2G1XD75_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24195</name>
        <name evidence="3" type="ORF">CYQ11_21880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49170">
        <property type="protein sequence ID" value="PHQ49170"/>
        <property type="gene ID" value="BLA24_24195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15180">
        <property type="protein sequence ID" value="PPT15180"/>
        <property type="gene ID" value="CYQ11_21880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046096">
        <property type="entry name" value="DUF6114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19609">
        <property type="entry name" value="DUF6114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="15844" checksum="C74DEED869664A26" modified="2018-01-31" version="1">MSADTRPRLFDTLGRTRSSFWDWRGRRPFWGGLLCILAGVPIMYIPYQTMTLGDLHIRLATTAGAGSLIIGVLLIVLGLTMWFQPQSRVFAGVAAILLALVSLVVSNFGAFLVGFLLALVGGGLGVSWMPGKPLPEAPAEKTAGSPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDH8</accession>
    <name>A0A2G1XDH8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24860</name>
        <name evidence="4" type="ORF">CYQ11_21210</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49293">
        <property type="protein sequence ID" value="PHQ49293"/>
        <property type="gene ID" value="BLA24_24860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15057">
        <property type="protein sequence ID" value="PPT15057"/>
        <property type="gene ID" value="CYQ11_21210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="163"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="303" mass="29699" checksum="65597F3F3C9A844B" modified="2018-01-31" version="1">MTSTAAPGTPTAGGVRAAPAPAGVGSLGGIGLVLAGTVSVQFGSAVAALLFPRAGALGVVALRVTIAAVLLLAFCRPRLRGHSRSDWAVAGAFGLALGGMNILFYQAIDRIPLGPAVTLEVLGPLLLSVVAARRAVSLVWAGLALAGVFLLGQEGFDRLNPAGAGFALGAGVMWAAYIVFNSRAGARFPRLDGLAVAMGVAALVSLPLGIGSAGGTLLEPGVLGLGAAVALLSSGVPYALELLALRRLSAATFAVLMSLAPAVAALAGFLVLGQTLSAPQCLAIVLVVVASAGAVRAGASGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDL6</accession>
    <name>A0A2G1XDL6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24800</name>
        <name evidence="4" type="ORF">CYQ11_21270</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49281">
        <property type="protein sequence ID" value="PHQ49281"/>
        <property type="gene ID" value="BLA24_24800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15068">
        <property type="protein sequence ID" value="PPT15068"/>
        <property type="gene ID" value="CYQ11_21270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="181" mass="19775" checksum="26C04510E2CEC2D6" modified="2018-01-31" version="1">MIRSATPADVPVIHTMIRELAEYERALDEARATEEQLRDALFGPDAAVFALIAESDGGAEGDTGSGGEVVGFALWFRNFSTWTGTHGVYLEDLYVRPQARGGGHGKALLAALARICVDRGYERFEWSVLDWNTPSIAFYKSLGAEAMDEWTVRRLSGESLHSLAALAQSDENPNRPTSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDM9</accession>
    <name>A0A2G1XDM9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol system anti-sigma-R factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24940</name>
        <name evidence="3" type="ORF">CYQ11_21130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49305">
        <property type="protein sequence ID" value="PHQ49305"/>
        <property type="gene ID" value="BLA24_24940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15044">
        <property type="protein sequence ID" value="PPT15044"/>
        <property type="gene ID" value="CYQ11_21130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="110" mass="12160" checksum="24ED39ECACE4836F" modified="2018-01-31" version="1">MSCGDPHETDCSEVLDHLYEFLDHEMPEGDCAKFEVHIDECSPCLEKYGLEQAVKKLVKRCCGHDDVPADLRSKVMGRIELIRSGQTVPEQDVVAEARAAEAAEAAAQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDN4</accession>
    <name>A0A2G1XDN4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_24790</name>
        <name evidence="9" type="ORF">CYQ11_21280</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49279">
        <property type="protein sequence ID" value="PHQ49279"/>
        <property type="gene ID" value="BLA24_24790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15070">
        <property type="protein sequence ID" value="PPT15070"/>
        <property type="gene ID" value="CYQ11_21280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="8"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="534" mass="57296" checksum="6459611C48B5F17C" modified="2018-01-31" version="1">MDVMPLLILVAGGAAIAGLARRTPVPAPLLLVAAGLLASYVPGVPDYTLDPDVVLPLLLPPLLHTAALDSSYLDLRANMRPVALLSIGYVLFATLTVGYVASRVVPGLPDAAALVLGAVVAPPDAVAATAIARRLGLPSRITTILQGESLVNDATAITAYRVALAAAVGAGATWAEGIRAFAVASLGGIGVGLVLMVPIHWLRKHLREPLLQNTLSLLIPFVAYAAAEQVHASGVLAVVVVALYLGHRSWQVDFATRLQEAAVWKMVAFILESAVFALIGLQLRVVLRDLGTYGLGEAAWYAVALFVAVVAARFLWVFPATFLPRALSARIREREPDTNWKAPVVVGWAGMRGVVSLAIAFSIPVATRDGAPFPARNLILFLTFTTVIGTLVVQGLTLPPLIRRLRLPERDTGADTLAEAQAQSEASAAAEARLEELLADERNTLPQPLADRLRAVLERRRNAVWERLGAVDERTGESVDDTYRRLAREVIEAEREVFVALRDARRIDDEMLRTLLRRLDLEEAAAYREEGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDU9</accession>
    <name>A0A2G1XDU9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25190</name>
        <name evidence="3" type="ORF">CYQ11_20880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49349">
        <property type="protein sequence ID" value="PHQ49349"/>
        <property type="gene ID" value="BLA24_25190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15003">
        <property type="protein sequence ID" value="PPT15003"/>
        <property type="gene ID" value="CYQ11_20880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="304" mass="31563" checksum="FE43DBA09D660A76" modified="2018-01-31" version="1">MRVLLLGANGYLGRFVADRLLADPAVQLTALGRGDDADVRFDLATGSPGALTRFLNAVHPGVVINCAGATRGGARELARHNTVAVATVCESLRRSGCGARLVQVGCSSEYGPSQPGSSTAEDAVPRPGGPYGVSKLAATELVLGSGLDAIVLRVFSPVGPGTPAGSPLGRLAEAMRRAMQSGDNELKLTGLGVQRDFVDVRDVARAVHAASLSAAQGAVNIGTGRAVRLRDAATLLARVAGFGGALHELDDPHLGTPPAYPYPDGCGSWQQADVRTARDRLGWRPRIGLEESLADIWMEAACRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE10</accession>
    <name>A0A2G1XE10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25660</name>
        <name evidence="3" type="ORF">CYQ11_20410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49431">
        <property type="protein sequence ID" value="PHQ49431"/>
        <property type="gene ID" value="BLA24_25660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14919">
        <property type="protein sequence ID" value="PPT14919"/>
        <property type="gene ID" value="CYQ11_20410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="139" mass="14961" checksum="CC9502196FD72907" modified="2018-01-31" version="1">MVGVSDGAETLASTPGFAEWSFPAEPGAVRTARTLVRDTLREWGMHALTDVTVLLVSELVTNSLRYASGPIGVRMYSRAGPFLLVEVSDPLPEPPRERVAAEDDEGGRGLQLVALASRRWGTRPGNTGKTVWFELALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE44</accession>
    <name>A0A2G1XE44_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25945</name>
        <name evidence="4" type="ORF">CYQ11_20125</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49482">
        <property type="protein sequence ID" value="PHQ49482"/>
        <property type="gene ID" value="BLA24_25945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14868">
        <property type="protein sequence ID" value="PPT14868"/>
        <property type="gene ID" value="CYQ11_20125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="255" mass="27726" checksum="F2720445F4336D13" modified="2018-01-31" version="1">MGNAQTIINIAKAEVGYHEGRSNGHWTNWQKYSPAVPGLEWSQNQAWCAVFASWVAMKAGLASLYPRTASCATGVEWFKSRNRWSAYPAVGAQVFYGSGGGTHTGIVYAYDSTYIYTVEGNTNADGSAEGDGVYLKKRERRSSYVYGYGYPAFAEGIDSADPAWKSSKDRGDSTPFPGRQAFRLGQSHPAVTTLGKRLVAHGLGRFYSEGPGPRFTEADRKATEAFQRAQGWSGSEADGYPGPSTWTRLMAPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEG3</accession>
    <name>A0A2G1XEG3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DeoR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_26575</name>
        <name evidence="7" type="ORF">CYQ11_19060</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49591">
        <property type="protein sequence ID" value="PHQ49591"/>
        <property type="gene ID" value="BLA24_26575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14690">
        <property type="protein sequence ID" value="PPT14690"/>
        <property type="gene ID" value="CYQ11_19060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="345" mass="35624" checksum="365EE47C9B764397" modified="2018-01-31" version="1">MVVGVTVGFVFAAERRQLILEMVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFTRESGFPQKSHLATAEKTAIADLAASFVEEGEAVVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVSRAFLSGSGLTAERGLSTSNMLSASVDRALVQAAAEVVVLADHTKLGTDTMFQTVPTDVITRLVTDEPPAHDDRAATELQALADQGVHISVAGPGAGSGSSAGTVHGDAVGPARRRDVPPLPGQRRNLPLGHGQSPGPGQGGPPGAQLRSAVSLGEQPSARVADLAPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEH2</accession>
    <name>A0A2G1XEH2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_26890</name>
        <name evidence="4" type="ORF">CYQ11_18745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49644">
        <property type="protein sequence ID" value="PHQ49644"/>
        <property type="gene ID" value="BLA24_26890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14634">
        <property type="protein sequence ID" value="PPT14634"/>
        <property type="gene ID" value="CYQ11_18745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="68" mass="7626" checksum="43BD6C05CBD35FB5" modified="2018-01-31" version="1">MSMHSEQHIPDWRKSSYSSAGDEDGSDNCLEVNDTHPTRIRVRDSKLTHSPVLTVPSSSWSAFVALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF30</accession>
    <name>A0A2G1XF30_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_19360</name>
        <name evidence="12" type="ORF">CYQ11_11440</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49811">
        <property type="protein sequence ID" value="PHQ49811"/>
        <property type="gene ID" value="BLA24_19360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13413">
        <property type="protein sequence ID" value="PPT13413"/>
        <property type="gene ID" value="CYQ11_11440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="10">
        <location>
            <begin position="56"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="306" mass="33997" checksum="5C18774E4C81B8D8" modified="2018-01-31" version="1">MRAQFVLSEIGVGLRRNLTMTFAVIVSVALSLALFGGSLLMREQVSSMKGYWYDKVNVSIYLCNKNDADTARTEAACAKGPATEDQKKQIRADLEKMPIVQSVQFESTDEAWKHYREQFPKSPIAAFLTPDQMQESFRVKLKDPSKYKVISSAFSQRAGIQEVEDQRKTLEPLLNLLNGMNIAALGVMALMLIVALLLIVNTVRVSAFSRRRETGIMRLVGASSFYIQTPFIMEAAFAGLLGAGFACVLLVGGQYFLVNNWLVHQIDVIQFIGWDAVFAKMPLVIAIGLLMPALAAFIALRKYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFB2</accession>
    <name>A0A2G1XFB2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">BLA24_20085</name>
        <name evidence="12" type="ORF">CYQ11_10705</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49928">
        <property type="protein sequence ID" value="PHQ49928"/>
        <property type="gene ID" value="BLA24_20085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13296">
        <property type="protein sequence ID" value="PPT13296"/>
        <property type="gene ID" value="CYQ11_10705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="287"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="459"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="606" mass="66021" checksum="A8F1B69542171C75" modified="2018-01-31" version="1">MCGIVGYIGKRDVAPLLLEGLQRLEYRGYDSAGIALHASGKAGGLKSAKAKGRVRELESRLPKRFAGTTGIAHTRWATHGAPNDVNAHPHLDAEEKVAVVHNGIIDNASDLRAKLTAEGYVFVSDTDTEVLAHLIARSEAATLEEKVREAVRHIEGTYGIAVLHADFPDRIVVARNGSPVVLGIGEKEMFVSSDVAALVSHTRQVVTLDDGEMATLKADDYRTYTTEGSRTSAQPTTVEWEAESYDMGGHDTYMHKEIHEQAEAVDRALRGRIDDRFSTVHLGGLNLDARDARAVRRVKILGCGTSYHAGQIGAQMIEELARIPADAEPASEFRYRNPVVDPDTLYIAVSQSGETYDVLAAVQELKRKGARVLGLVNVVGSAIARETDGGIYVHAGPEVCVVSTKCFTNMVVSFGLLALHLGRTRDLSVADGKRIIEGLRKLPAQIEEILANEAQIEELAKEYAEAKSMMFIGRVRGYPVAREASLKLKEVSYIHAEAYPASELKHGPLALIEPAMPTVAIVPNDELLEKNRAALEEIKARSGRILAVAHQEQEKADHTIVVPKNEDELDAILMGIPLQLFAYYTAKAMGRDIDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFD0</accession>
    <name>A0A2G1XFD0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_20170</name>
        <name evidence="11" type="ORF">CYQ11_10620</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49942">
        <property type="protein sequence ID" value="PHQ49942"/>
        <property type="gene ID" value="BLA24_20170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13281">
        <property type="protein sequence ID" value="PPT13281"/>
        <property type="gene ID" value="CYQ11_10620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="840"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="51"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="366"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="701"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="399"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1057"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ49942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1266" mass="135297" checksum="22F129B0C7626EED" modified="2018-01-31" version="1">MKSAAHGVGAFRQQYEGGDSGRSRVAATDTTGQGWARRLTGYCWRYRATVLLALGSSLAGMAVMALVPLIPKLIIDDVIGSHQRPLAPWATLLVVAAVVVYGLTYVRRYYGGRLALDVQHDLRTEMYDAIARLDGRRQDELSTGQVVGRATSDLQLIQSLLFMLPMMIGNILLFVISLVVMAVLSPLLTVVALAVAPAVWFLAKRSRVKLFPATWYAQGQAAAVAGVVDGAVTGVRVVKGFGQEAQEAGKLREVSRRLFAGRLRTVRLNSRYTPALQAVPALGQVAMLALGGWMATRGQVTLGTFVAFSTYLAQLVGPVRMLTMVLTVGQQARAGVERVLELVDTEPVVTERPGAHDLPADAPATVEFDDVTFGYDPGRPVLDGVSLRLEPGETVAVVGASGSGKSTLALLLPRFYDATSGTVRVGGQDVRDLTLSSLRAAIGLVPEDSFLFSDSIRDNIAYGVPGASDERVRAAARAAQADGFISALPDGYDTKVGEQGLTLSGGQRQRVALARAILTDPRLLLLDDATSAVDARVEHEIHEALRGVMAGRTTLLIAHRASTLALADRIAVLDGGRLVDVGTAAELEERCALYRQLLTDPEELAGLAKDPAGAVAGTPAPAGDARRHPVDGVTPHLWVRGDTPGAHGALAGMPATPELLAKVEALPPATDSPDIDEERAALPEESYGLRRLLRGFGAPLALSLLLVAVDALAGLLLPVLIRHGIDQGVERLALGAVWTASALALLVVVAQWAAQVGETRLTGRTGERVLYALRLKIFAQLQRLGLDYYERELTGKIMTRMTTDVDAMSTFLQTGLVTAVVSVFTFFGILVALLVIDVELALVVLATLPPLVAGTFFFRRQSVKAYELARERVGVVNADLQETVAGLRVVQAFRREATGARRFAERSDRYRRARVRGQWLISVYFPFVQLLSSVAAAAVLTVGAGRVSDGTLTAGALVAYLLYIDLFFAPVQQLSQVFDGYQQATVSLGRVQDLLREPTTTPVAASPRTVRKLSGEVVFDDVRFQYEAGEDALSGIRLTIPAGQTVAFVGETGAGKSTLVKLVARFYDPTAGAVLVDGHDLRELDPVAYRHRLGVVPQEPYLFPGTVRDSIAYGRPDASDAEVEAAARAVGAHEMVAALDGGYLHPVAERGRNLSAGQRQLIALARAELVDPDVLLLDEATAALDLATEAMVNRATDSLAGRRTTLVVAHRLTTAARADRVVVLDRGRVVEDGTHDELLAQDGRYAELWRTFTGEGVPARRVGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFQ9</accession>
    <name>A0A2G1XFQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_20965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50072">
        <property type="protein sequence ID" value="PHQ50072"/>
        <property type="gene ID" value="BLA24_20965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="157" mass="17478" checksum="8DD77A862120E481" modified="2018-01-31" version="1">MRRGRPGALPRGGGTPHARRAMGEERTLTSVGPVDTGERTGEEDASRLWHITLSVSGAEAPLKEVRRGLEQLAHDHPFLLTSRYANDHAEIRYWEEARDLHDAAAVALRLWGEHRSTAQLPPWEIVGLEVIDRETYHQRIAEGYGPLPASPVGVHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG23</accession>
    <name>A0A2G1XG23_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aceE</name>
        <name evidence="12" type="ORF">BLA24_21685</name>
        <name evidence="13" type="ORF">CYQ11_09100</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50188">
        <property type="protein sequence ID" value="PHQ50188"/>
        <property type="gene ID" value="BLA24_21685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13028">
        <property type="protein sequence ID" value="PPT13028"/>
        <property type="gene ID" value="CYQ11_09100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="150"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="494"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ50188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="910" mass="101065" checksum="D3C4D658B453D0CA" modified="2018-01-31" version="1">MASGSDRNPIIIGGLPSQVPDFDPEETQEWLDSLDAAVDERGRERARYLMLRLIERAREKRVAVPEMRSTDYVNTIATKDEPFFPGNEEIERKVLNATRWNAAVMVSRAQRPGIGVGGHIATFASSASLYDVGFNHFFRGKDEGDGGDQIFFQGHASPGVYARAFLLDRLSEQQLDAFRQEKSKAPYGLSSYPHPRLMPDFWEFPTVSMGLGPLGAIYQARMNRYMQARGIADTSKSHVWAFLGDGEMDEPESLGQLSLAAREGLDNLTFVVNCNLQRLDGPVRGNGKIMQELESQFRGAGWNVIKLVWDRSWDPLLAQDRDGILVNKLNSTPDGQFQTYATETGAYIREHFFGDDQRLRKMVEGMTDDQILHLGRGGHDHKKIFAAYAAAKAHKGQPTVILAQTVKGWTLGPNFEGRNATHQMKKLTVEDLKRFRDRLHIPIADKELESGLPPYYHPGRDSEEIQYMHDRRKSLGGYVPTRVVRAKPLQLPGDKAYAPIKKGSGQQSIATTMAFVRLLKDLMRDKEIGKRFVPIAPDEYRTFGMDSLFPSAKIYNPLGQQYEAVDRELLLAYKESPTGQMLHDGISEAGCTASLIAAGSAYATHGEPLIPIYVFYSMFGFQRTGDQFWQMADQLARGFVLGATAGRTTLTGEGLQHADGHSHLLASTNPGVVAYDPAFGYEIAHIVQDGLRRMYGENAEDIFYYLTVYNEPIQHPAEPENVDAEGILKGLYRYKAAEAGAVPAQILASGVAVPWALEAQRILAEEWNVKADVWSATSWNELRRDAIEVEEHNLLHPEEEQRVPYVTKKLAGAEGPKVAVSDWMRAVPDQIARWVPGSYQSLGADGFGFADTRGAARRFFHIDAQSIVLGVLTELAKEGKIDRSALKQAIDRYQLLDVAAADPGAAGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG67</accession>
    <name>A0A2G1XG67_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_21900</name>
        <name evidence="4" type="ORF">CYQ11_08885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50226">
        <property type="protein sequence ID" value="PHQ50226"/>
        <property type="gene ID" value="BLA24_21900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12990">
        <property type="protein sequence ID" value="PPT12990"/>
        <property type="gene ID" value="CYQ11_08885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758452" evidence="2">
        <location>
            <begin position="42"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="233" mass="22374" checksum="5B4C9401CEEC9917" modified="2018-01-31" version="1">MTSPSTPRRHRALLAAGAGLAVTVALSLSGTGTASAGTADAASTTVQPAGHSFAATLNGAASFKAGSVSASCEVSASAPSAGSGNNKVPDAPGNTNASGPVSSGINAPTYSDCTSSLPVDVSVTTSGTWTVSMQNGSPITASLTIPTGGFVLKSSGLANCTITAAPDGPVTFPATFTNGSGGTPSRITVADAEVAVKVTGGFGCPTAATTSVFNAVYDVTDVTDPAARITVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGC4</accession>
    <name>A0A2G1XGC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22245</name>
        <name evidence="3" type="ORF">CYQ11_08540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50277">
        <property type="protein sequence ID" value="PHQ50277"/>
        <property type="gene ID" value="BLA24_22245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12937">
        <property type="protein sequence ID" value="PPT12937"/>
        <property type="gene ID" value="CYQ11_08540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="214" mass="22499" checksum="5A397FA65CF903CE" modified="2018-01-31" version="1">MDAVRVATLRDMLAGTEWLQATRRFAGTLRASVGAHGGGLLLVGTREYEPWHLAAHLEDEAAWAGLPELTPTLVRHRVPAGAPAHLSVGLGRLEAARRGETLLVVAAGRPGEGLLERVHDARRGGATVLALEGAPARDAPGPGPGDTTAHAEMLALAHDALSVPDSAALDLDTVQHLVSAAAGENGLPSPRGRRFRDRLSRLADQLTAPPPQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGF2</accession>
    <name>A0A2G1XGF2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22415</name>
        <name evidence="4" type="ORF">CYQ11_08370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50307">
        <property type="protein sequence ID" value="PHQ50307"/>
        <property type="gene ID" value="BLA24_22415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12906">
        <property type="protein sequence ID" value="PPT12906"/>
        <property type="gene ID" value="CYQ11_08370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="330"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="424" mass="44931" checksum="D61426B2250D6A29" modified="2018-01-31" version="1">MRVRGGLLAGAQGLWLALFGLIGSVLLFTLTVVSIVLVVLGIGFFTTPVMIKALRAFADQRRVLAHEWSGVRIPSPYRPPVPAGGRRGGLAGQVEGCVALLKDPATWRDLQWLLVDMTAGFVLAILAPCLLLYAVWGPVLALGVWKPIVEAGGNEWFTFVHVTGQESADSAAVLGLAYGVLGLFVNPGLLRTNFHLTRHFLRPTRERELALRVDRLTETRHDALDSSAAELRRIERDLHDGAQARLVAVGMSLGAVEALIEKDPQQARKLVAAARATSAEALTELRDLVRGIHPPVLAERGLGDAVRALALRMPLPVEVDVDLAGRAAEPVESAAYFAVSELLTNAAKHAGAERVWVDVHHARGTLRIAVTDDGRGGADPAGGSGLAGLERRLGAFDGVLAVSSPRGGPTMITVEIPCALAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGX2</accession>
    <name>A0A2G1XGX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16760</name>
        <name evidence="3" type="ORF">CYQ11_16525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50488">
        <property type="protein sequence ID" value="PHQ50488"/>
        <property type="gene ID" value="BLA24_16760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14257">
        <property type="protein sequence ID" value="PPT14257"/>
        <property type="gene ID" value="CYQ11_16525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="171"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="512" mass="54678" checksum="7325B38D0BEC8E8C" modified="2018-01-31" version="1">MSTTHLPAPDPARTARLREALLAAAFTADGLLDLLGAPAYAALARSETVPALRATRGDSPLETLVRLFLLQRPVAYERAAAALPVDDCLADGWLVRDGSDADAVRASLDVRPYGGPEGQDWWIVSDLGCAVGGAGGIAGGADGAGGVDRSELVLGVGGASTTLAGITVRKPVGSALDLGTGSGIQALHAAQHATKVTATDLNPRALHITRLTLALSGAPEADLRQGSLFEPVAGETFDLIVSNPPFVISPGARLTYRDGGMGGDDLCRTLVRQAADRLNEGGYCQLLANWQHVEGEDWRDRLASWVPRGCDAWIIQREVQDVAQYAELWLRDAGDHRSTPEEYVARYDAWLAEFEARRTKAIGFGWITLRKSGAERPSAIAEEWPHPVEQPLGATVAAHFERQDFLRTHDDAALLATRFRLADEVVQEQVGLPGAEDPEHVVLRQNRGMRRATKVDTVGAGFAGVCDGTLEAGRILDAIAQLVGEDPVLLRDRTPEAIRMLVEQGFLEPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH83</accession>
    <name>A0A2G1XH83_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16835</name>
        <name evidence="3" type="ORF">CYQ11_16450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50499">
        <property type="protein sequence ID" value="PHQ50499"/>
        <property type="gene ID" value="BLA24_16835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14246">
        <property type="protein sequence ID" value="PPT14246"/>
        <property type="gene ID" value="CYQ11_16450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="35954" checksum="5491575F397520D9" modified="2018-01-31" version="1">MKIAFVGKGGSGKTTLSSLFIRHLAAGRAPVIAVDADINQHLGAALGLDEAESAALPAMGARLPLIKDYLRGTNPRIASADTMIKTTPPGEGSRLLRVGEDNPVYAACARTVRLDDDASVRLMATGPFNDSDLGVACYHSKVGAVELCLNHLVDGPDEYVVVDMTAGSDSFASGMFTRFDMTFLIAEPTRKGVSVYRQYKEYARDFGVSLKVVGNKVQGQDDLDFLRTEVGEDLLTTVGHSDWVRAMEKGRPPRFELLEEANQQALRTLRAAADGMYEHRDWQRYTRQMVHFHLKNAESWGNAKTGADLAAQVDPAFVLDERLLAAPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH88</accession>
    <name>A0A2G1XH88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17490</name>
        <name evidence="4" type="ORF">CYQ11_15785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50595">
        <property type="protein sequence ID" value="PHQ50595"/>
        <property type="gene ID" value="BLA24_17490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14150">
        <property type="protein sequence ID" value="PPT14150"/>
        <property type="gene ID" value="CYQ11_15785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="262"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="480" mass="49921" checksum="00D11AFA353C6580" modified="2018-01-31" version="1">MTTPHLPKVAGISPPAPAPAHTSAPAVPHPPAAAEPAVPAPGLLVQDRLAGWVSDLTTLQELTERLTRTATLDDALHELLRAGASLVGAGRGLVTLHPAAGTGHPVTAALGLGRADLGHIETIPHDPGAPGSPYVRLLDDLPPAGVRTGTAHPDIAREEGLDPRHREVAARLGYGASYAVPLESAVSGPEGGAPPAAGRIGAAVWLYDEPAEPTDRQRHLAGLYCAHATEHLARLLELTRARETVAALREELLPSRLPRVPGVRLAVRHRTGPQGGGDWYDALPLPDGALGLAIGGITGSGPGAVAATGRLRASLRAYAVMEGEDPVAVLSDLELLLRITEPARTATALFAYCEPAVRKVVIAGAGHCSPLIIGSGRAEYVETSLSAPLGMLACWEAPSVEIEPEPGETLLFYSDGLLHRTGDAIDRAFARLHAAAAGVPRAARHDPEAIADHVLRTVLPEDDDPADGREDVVLLVAHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH95</accession>
    <name>A0A2G1XH95_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_17605</name>
        <name evidence="2" type="ORF">CYQ11_15670</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50614">
        <property type="protein sequence ID" value="PHQ50614"/>
        <property type="gene ID" value="BLA24_17605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14131">
        <property type="protein sequence ID" value="PPT14131"/>
        <property type="gene ID" value="CYQ11_15670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="302" mass="34227" checksum="80BD734A21A536A7" modified="2018-01-31" version="1">MSHDRGYRIAPRRVSFTWHDTPLHWIPDEPTATHVINVLHLLLPAGERWFVKVFKEALPLVRDEALLKDVKGFMGQEATHSVQHAYVLDHLAEQGLDTSPYTRHVDFLFDVLLGERPPFGLPVTDREWLRFRLSVIAATEQFTAVLGDWVLQAEGLDHAGSDPVMLDLLRWHGAEEVEHRSVAFDMYEHCGGELPGRYARRVLGMAITAPVLMYLWTWGTDYLLRRDPRLASRGRYSLREYNRAVAKGLLPSLRELGSAVPRYLRRTYHPSQEGSLRRAVDYLATSPAARAAAGAMGRAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHF1</accession>
    <name>A0A2G1XHF1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17930</name>
        <name evidence="4" type="ORF">CYQ11_15345</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50674">
        <property type="protein sequence ID" value="PHQ50674"/>
        <property type="gene ID" value="BLA24_17930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14071">
        <property type="protein sequence ID" value="PPT14071"/>
        <property type="gene ID" value="CYQ11_15345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="349" mass="37354" checksum="663EC470258EA11A" modified="2018-01-31" version="1">MAGSVHREPDVEESESLRSDANTAGPMTDPVPGPRPSDSQPVAVPGPLSSGEVVSRETPPPMPRPEQTRVMVVANQKGGVGKTTTTVNLAASLALHGNRVLVIDLDPQGNASTALGIDHHAEVPSIYDVLVDNRKLSDVVQPVTDVEGLFCAPATIDLAGAEIELVSLVARESRLDRAIKAYEQPLDYILIDCPPSLGLLTVNALVAGAEVLIPIQCEYYALEGLGQLLRNVELVRGHLNPKLHVSTILLTMYDGRTRLASQVADEVRSHFGQEVLRTSIPRSVRISEAPSYGQTVLTYDPGSSGALSYLEAAREIALRGVGVHYDGTRAHTVGHQQQQDQHSMAEGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHK1</accession>
    <name>A0A2G1XHK1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class E sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_18075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50697">
        <property type="protein sequence ID" value="PHQ50697"/>
        <property type="gene ID" value="BLA24_18075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="315" mass="34365" checksum="AF4840DDBD1B7177" modified="2018-01-31" version="1">MTTLRPEQTPSWRLPDPAPYLHGPGPEPAPEPPPPAGSTRYGTGRVAQPLPPEDDATMSLRRVEPPPPVVTGGRAERRRAAQRAARARKDSIGVVVSRLTGELFITLGVVMLLFVAYQLWWTNVIAQRQAGGAAKDLQHSWDRGEGADRDAGAFSPGQGFAIVYIPALDVKAPIAQGIGKHKVLDRGMVGHYAEGPLKSAMPWDKQGNFALAGHRNTHGEPFRYVNRLKPGDKIVVETQSAFYTYEMTSRLDQTPPANVRVIDPVPAGSGFTGPGRYITLTTCTPEFTSTYRMIVWGKMVDERPRSKGKPDALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHZ5</accession>
    <name>A0A2G1XHZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16955</name>
        <name evidence="3" type="ORF">CYQ11_16325</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50868">
        <property type="protein sequence ID" value="PHQ50868"/>
        <property type="gene ID" value="BLA24_16955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16605">
        <property type="protein sequence ID" value="PPT16605"/>
        <property type="gene ID" value="CYQ11_16325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="47"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="33459" checksum="76CA62A2A21C88C6" modified="2018-01-31" version="1">MRARYGVPLGITAVGAAGLAYAAGYEVRSFRLRRVTVPVLPAGMRPLRILQVSDIHMVGGQRKKQRWLQSLAGLRPDFVINTGDNLSDPEGVPETLDALGPLMDFPGAYVFGSNDYYGPKLRNPARYLLEKATGRHGLNGNAPAVGVIHNPWEELRDGFDAAGWVNLTNTRGSLKIDGLEIALTGLDDPHIKRDRYEHVSGGPEEAADFSLAVVHAPYLRVLDAFTADRYPLILAGHTHGGQLCIPFYGALVTNCDIDTRRVKGLSTHRAGGHQSYLHVSAGCGTNRYTPVRFACPPEATLLTLVARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI25</accession>
    <name>A0A2G1XI25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_18990</name>
        <name evidence="11" type="ORF">CYQ11_14290</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50841">
        <property type="protein sequence ID" value="PHQ50841"/>
        <property type="gene ID" value="BLA24_18990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13901">
        <property type="protein sequence ID" value="PPT13901"/>
        <property type="gene ID" value="CYQ11_14290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="100"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="284"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="526" mass="55821" checksum="62C9BCE15467349F" modified="2018-01-31" version="1">MTRSAARPGHSERPDRPDRPGRSGRSRSANRPSGRAGGRSEAPSRRSAPQQGGEFETPVATTPALPAVESFAALDMPAALLSTLTREGVTEPFPIQAATLPNSLAGRDVLGRGRTGSGKTLAFGLALLARTAGRRAEAGRPLALVLVPTRELAQQVTDSLSPYATAVNLRTVTVVGGMSIGRQAQTLARGAEVLVATPGRLADLIQRGDCRLDDVAITVLDEADQMADMGFLPQVTRLLDQVRPDGQRMLFSATLDRNVDRLVRRFLTDPVTHSVDPSAGAVVTMEHHLLHLADDTVKKAAVTRIAAREGRVIMFVDTKRGADRLVKRLLSQGVRAAALHGGKSQPQRNRVLEQFRTEQVTALIATNVAARGIHIDGLDLVVNIDPPVDHKDYLHRGGRTARAGESGTVVTLVLPEQRREMSRMMATAQITPNAVRVNPEDAELVRITGAREPSGVPVVIAPPQQPQPQKRAPQAQSSSRRQPQRQAGRARPGGSGRPRRRGGSGGGAGGGTAGNGGGRNPRPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI60</accession>
    <name>A0A2G1XI60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18705</name>
        <name evidence="2" type="ORF">CYQ11_14575</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50913">
        <property type="protein sequence ID" value="PHQ50913"/>
        <property type="gene ID" value="BLA24_18705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16562">
        <property type="protein sequence ID" value="PPT16562"/>
        <property type="gene ID" value="CYQ11_14575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="29246" checksum="B27438826D05D1EB" modified="2018-01-31" version="1">MTNISAPQPVRLAAGDAEVTVDPAGGCRLSSLTIAGTELLRQGERYGAFPMVPWCGRIALGRFRNGGDVHQMPLNAAPHAIHGTGRDAAWRTARADKRSAAFTYDLAEPWPYSGRVTQLVELSEDSLTLTMGVETYGDSFPAQAGWHPWFLRNLGSGKDVELDFAAAWQEERGADHLPTGHRIDPRPGPWDDCFGMPDGVDVTLTWPGALELKVTSRAEWVVVYDEQTEAVCVEPQSGPPNGLNTDPRLVTPIDPLEISTTWSWRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI78</accession>
    <name>A0A2G1XI78_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Resolvase/invertase-type recombinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_14065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50925">
        <property type="protein sequence ID" value="PHQ50925"/>
        <property type="gene ID" value="BLA24_14065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="86" mass="9484" checksum="3CAD34B2A5C58C15" modified="2018-01-31" version="1">MGHPEHVAAVLRVAAGYTRQSKKKADKSEASPAAQDEANEKKARDRGCRFLRHYRDVGVSGYGPNANRKAFERLLNACRAGKVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG8</accession>
    <name>A0A2G1XIG8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">BLA24_14810</name>
        <name evidence="11" type="ORF">CYQ11_13260</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51048">
        <property type="protein sequence ID" value="PHQ51048"/>
        <property type="gene ID" value="BLA24_14810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13729">
        <property type="protein sequence ID" value="PPT13729"/>
        <property type="gene ID" value="CYQ11_13260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="15962" checksum="33864889566BDC85" modified="2018-01-31" version="1">MAEQNPLKVHNLRPAPGAKTAKTRVGRGEASKGKTAGRGTKGTKARYQVPERFEGGQMPLHMRLPKLKGFKNPAHKQFQVVNLDKLAALYPQGGEVTVADLVAKGAVRKNELVKVLGQGEISVALQVTVDAVSGSAQEKITAAGGTVTELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIJ3</accession>
    <name>A0A2G1XIJ3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14520</name>
        <name evidence="3" type="ORF">CYQ11_13555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51001">
        <property type="protein sequence ID" value="PHQ51001"/>
        <property type="gene ID" value="BLA24_14520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13777">
        <property type="protein sequence ID" value="PPT13777"/>
        <property type="gene ID" value="CYQ11_13555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14840" checksum="7FF8830890E4C21E" modified="2018-01-31" version="1">MTNSSVSTRATVEEFLARRLEGDPERTAALFAGTVDWLIAENPAVPWIRPRSTRADVADHWRDLAAGVAPDEGNSVESFVVDGAEAVLTGWLAGTVRFTGKSFRVPFAMRLTVEDGLITRFHVYEDSLAVAAACEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIR5</accession>
    <name>A0A2G1XIR5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_15345</name>
        <name evidence="5" type="ORF">CYQ11_12730</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51142">
        <property type="protein sequence ID" value="PHQ51142"/>
        <property type="gene ID" value="BLA24_15345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13636">
        <property type="protein sequence ID" value="PPT13636"/>
        <property type="gene ID" value="CYQ11_12730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="27043" checksum="36B61FDA380ECAA8" modified="2018-01-31" version="1">MGRSRRTIPEELLLLALDPATGTTAQPQSLDLGLAGAQLVELALAGRIAPDGDRIAVVHPRPTGDPTLDTALELLRRRGSPVRAVHWIGGPRLGLRQTYLTHLERCGMVHAVAGQMCGVLPTTRYQATDTAISREIRARLDSAIRTGVPPDPRTAALAALAHAVGLGKHLYPGNEGRSSRSRLRDLIRHDPMGGLVAHAVMDVQNGAAAQPRRTPAAAGSGGSSSSGSGRRTTAVRPAAEAAAQPVAHRRGVMARAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIS4</accession>
    <name>A0A2G1XIS4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">BLA24_15050</name>
        <name evidence="14" type="ORF">CYQ11_13020</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51091">
        <property type="protein sequence ID" value="PHQ51091"/>
        <property type="gene ID" value="BLA24_15050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13686">
        <property type="protein sequence ID" value="PPT13686"/>
        <property type="gene ID" value="CYQ11_13020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ51091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="11633" checksum="511716E41847F130" modified="2018-01-31" version="1">MADFSRLPGPNADLWDWQLLAACRGVDSSLFFHPEGERGAARSARETSAKEVCMRCPVRAECAAHALAVREPYGVWGGLTEDEREELMGRARHRSITASGAGAGAMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ24</accession>
    <name>A0A2G1XJ24_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15660</name>
        <name evidence="4" type="ORF">CYQ11_12415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51191">
        <property type="protein sequence ID" value="PHQ51191"/>
        <property type="gene ID" value="BLA24_15660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13585">
        <property type="protein sequence ID" value="PPT13585"/>
        <property type="gene ID" value="CYQ11_12415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758489" evidence="2">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="167" mass="17076" checksum="383F0ABB69AABDC0" modified="2018-01-31" version="1">MTLGAAALIVGLLNATLCGCADAGGLKVSGPGLSPTPSAAPVFVAEAAGRPPLSRPAAFAPNDSVRLFDLRWRSWGGAIAEATGALAGAWCEPGCRDDPHPVRVTLSGLVRQDRSAYYSRAAVVFDTGTSGGSAADPRPPAGITPKSRSALGDLRLFVPQQQSVPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ62</accession>
    <name>A0A2G1XJ62_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16260</name>
        <name evidence="2" type="ORF">CYQ11_11815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51294">
        <property type="protein sequence ID" value="PHQ51294"/>
        <property type="gene ID" value="BLA24_16260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13480">
        <property type="protein sequence ID" value="PPT13480"/>
        <property type="gene ID" value="CYQ11_11815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="75" mass="8031" checksum="6B5E37A0ED569B34" modified="2018-01-31" version="1">MEGKKKADDVAFMLGQVLKTMGIKVGDPDSWPQLTGRASLSGEPSVFLGSVPLPTAKKIANTLVYAESVRRSQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ75</accession>
    <name>A0A2G1XJ75_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15650</name>
        <name evidence="4" type="ORF">CYQ11_12425</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51189">
        <property type="protein sequence ID" value="PHQ51189"/>
        <property type="gene ID" value="BLA24_15650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13587">
        <property type="protein sequence ID" value="PPT13587"/>
        <property type="gene ID" value="CYQ11_12425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304727" evidence="2">
        <location>
            <begin position="31"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="499" mass="49404" checksum="979F0BAC7ABCD269" modified="2018-01-31" version="1">MRNAIRYAVLPALTAASLLAVTGCSSGSPAASGKGSDAEPVAAKAAAAADAAPQLAVAPAPAGAGAPSAVAHPSDGSAGKGPKAAKSALKVASFDQKSGRAVISGPTGGTGAGGAPKKGKGLAAQPSQSPAPSAQTNVSVGDVIASAPAPGAPQGVLAKVTKVLGKTEQGTEVNTAPATLDALLGDSEAKGKVPVDPSSVKVEPLLKGVNVSWTKPDGVHVGPKGAKVPLGNLRLDVGASIPTPASSPVKAEASATGFVQLAPEVDFSYDGRGFGGRGPGTASLALSGDWSSQWELKAEALATTDAKPLRLPFAKLHADPVIQVGPVPVVVNLDLTCYLQVDAEGKLSVDVKQDMKGDFRVGGAYSWGKGWSGISQANTEVSPVRATASASGKVKAALGAEASVGLYGAVGVSADLAPYLRAEGEASATASSDGKASASGKWAAYGGVDLTGSLQAHLKIFGTPVFERRIPLDLYHREWKLAGGEGSVSTAKQKKGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJS2</accession>
    <name>A0A2G1XJS2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_13310</name>
        <name evidence="4" type="ORF">CYQ11_01030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51483">
        <property type="protein sequence ID" value="PHQ51483"/>
        <property type="gene ID" value="BLA24_13310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11665">
        <property type="protein sequence ID" value="PPT11665"/>
        <property type="gene ID" value="CYQ11_01030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="2">
        <location>
            <begin position="100"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="235" mass="24169" checksum="572EF45FCA7EC85F" modified="2018-01-31" version="1">MRPRERRGEALAHAAVLSGAVTPGPPAPAGRGSAAGHTGRAAAYHDCVIRSPQAAPFGRFDESWPAVNRPELLAEPVAAALGQWVGAGPVESVLVVDTDPEVADTAAFSAAYDVPLDVSANCVVIAAKRGQEVTYAACVALATTRVDVNSAVRKRLGARKASFAPMDTAVAETGMEYGGITPVGLPKDWPLLVDEAVASAPYVLVGSGRRRSKLILPGAFLGQLPNAEVAAGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJX2</accession>
    <name>A0A2G1XJX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_13560</name>
        <name evidence="6" type="ORF">CYQ11_01280</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51527">
        <property type="protein sequence ID" value="PHQ51527"/>
        <property type="gene ID" value="BLA24_13560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11710">
        <property type="protein sequence ID" value="PPT11710"/>
        <property type="gene ID" value="CYQ11_01280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="220" mass="23409" checksum="0479229C127C1182" modified="2018-01-31" version="1">MTVRILLADDQPLVRSGLRVIMADHPDLEVVGEAATGSEAVRLVGDLGPDVVVMDIRMPGMDGIEATRLITAGPATTRVLVLTTFDEDDHVYGALRAGASGFVVKDMALDDILSAIRVVAAGDALIAPSVTRRLIADFVGRPDAAPEGAPRPVEGITEREREVLTLVGRGRSNTEIAEDLFITVATAKSHVSRLLTKLGARDRVQLVITAYEMGLVTVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK18</accession>
    <name>A0A2G1XK18_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Folate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Folate-binding protein YgfZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12850</name>
        <name evidence="6" type="ORF">CYQ11_17205</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51582">
        <property type="protein sequence ID" value="PHQ51582"/>
        <property type="gene ID" value="BLA24_12850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14374">
        <property type="protein sequence ID" value="PPT14374"/>
        <property type="gene ID" value="CYQ11_17205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="4">
        <location>
            <begin position="246"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="34956" checksum="ED1A6C563116AF7C" modified="2018-01-31" version="1">MRPSKSPLLSLPGAVPAEGPDEGVAAHYGDLFREQRLLADGTGFVDLSHRGVVTVTGPDRLSWLHLLLTQHVSDLPAGQATEALILSPHGHIEHALYLVDDGETTWAHVEPGTQEALIAYLESMKFFYKVEVADRTDDVAVTFLPAGSIVPAPQDVAVRETPYGRDLFLPRERLTEFAAEHGPAAGALAYEALRVEGHRPRLGLETDHRTIPHELGLIGVAVHLQKGCYRGQETVARVHNLGKPPRRLVFLHLDGSEVALPAHGAPVRLASDGPEGRQLGFVTTSARHHELGPIALALVKRNVPVDAALLVGEATAAAQEVVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKE4</accession>
    <name>A0A2G1XKE4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11520</name>
        <name evidence="3" type="ORF">CYQ11_02755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51713">
        <property type="protein sequence ID" value="PHQ51713"/>
        <property type="gene ID" value="BLA24_11520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11962">
        <property type="protein sequence ID" value="PPT11962"/>
        <property type="gene ID" value="CYQ11_02755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="144"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="38466" checksum="920CDD4AAE744B46" modified="2018-01-31" version="1">MSTDPAVEAVEASAYTFPTEVPEADGTLAWDSTTVVVVEARCGGETGLGWTYAPAAAASAVSGLLAGAVVGRCALDVAGANEAMGRAVRNAGRQGLVACALSAVDVALWDLKARLLGVPLVRLIGAVTEEVPVYGSGGFTTYHDTHLAAQLNSWVHGHGIERVKIKIGESWGRAVPRDLDRVRHARQTIGPGASLYVDANGAYTRKQAVRVGQALADLGVGWFEEPVSSDDLAGLRVVRDLCACDVAAGEYGYDLPYFARMAPVVDCLQADATRCGGLTAWLRAAAVAEAHGLEVSGHCAPHVHAHAAACVPNLRHLEWFHDHVRIESAFFTGALDPSGGSVRPGAGGEPGHGMRFRREEAAAHRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKJ9</accession>
    <name>A0A2G1XKJ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_11710</name>
        <name evidence="7" type="ORF">CYQ11_02950</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51746">
        <property type="protein sequence ID" value="PHQ51746"/>
        <property type="gene ID" value="BLA24_11710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11994">
        <property type="protein sequence ID" value="PPT11994"/>
        <property type="gene ID" value="CYQ11_02950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="353" mass="39469" checksum="69B2B4A0E58236A8" modified="2018-01-31" version="1">MSASSGPEVVVWDTTYACPLRCSHCYSESGRRAPRQLSHEDMLRVADALITLNPRVVALSGGEPLVVKGIFEVAGRLSRAGVKTAVYTSGWVMEPWMATGLATVFDEVIVSLDGATAQVHDRIRGRRGAFDRALSALTLLDGVARERRHQKRSPLWFGIDCVVIRSNFPQLEEFCTAIAPRFPELRTLTFNAAVPEGLASRPEFGRFELLDDEQVADLTSEHRRARLQELAPAGVRVFTTDNQNLVMRPDRFASGVDTLVMQIEPDGDVRALPVYEGTVGNILQESPLDLWYRGVSRLRDPFVVETLSAVRTMQDWAEAVRRMDYHFGSQEVRSRIERRSVRTNPPEFTALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKU0</accession>
    <name>A0A2G1XKU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11790</name>
        <name evidence="2" type="ORF">CYQ11_03030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51759">
        <property type="protein sequence ID" value="PHQ51759"/>
        <property type="gene ID" value="BLA24_11790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12007">
        <property type="protein sequence ID" value="PPT12007"/>
        <property type="gene ID" value="CYQ11_03030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="232" mass="24827" checksum="EDFDC6EBF484C4EE" modified="2018-01-31" version="1">MRAADASPDGQRLLVPLYVHPATDPAAWQDLVAAAPRLHGVVLNVADGPGHRPDPAFSAAAERLRGAGVRLLGYADTGYGRRPPRSVVADIRRHRRWYGVDGVFLDQVPVQAALVPRYRRLVRVARALGARTAVLNPGTHPDPGYARIADLLVTFEGSWEDYRRAGVPDWTADHPPGRFCHLVHGVPDGRAEQVARTAGRRGAGVHCAVPGTGANPWRSVPLTGSGLPGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKW3</accession>
    <name>A0A2G1XKW3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11770</name>
        <name evidence="3" type="ORF">CYQ11_03010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51856">
        <property type="protein sequence ID" value="PHQ51856"/>
        <property type="gene ID" value="BLA24_11770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16320">
        <property type="protein sequence ID" value="PPT16320"/>
        <property type="gene ID" value="CYQ11_03010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="68"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="302" mass="33203" checksum="0BB552C25B9D22F8" modified="2018-01-31" version="1">MTRDRGGDDRSVGRYVSEELRDRYFEACEAVMGLGPMPREEVDVETDFGTTHVYLHGPRVGPDARTPVVLVHGAGGNSAQWYPNVAALAGRRPVYAVDTLGDPGRSVQRAPIHEPEDAARWLEQVLDGLGLDRVHLVGHSYGGWLALNQAHRAPGRLASVTLLDPGGLEKTGLRFYAWIFVSALGMVAPVAIRRRLAAWLDQPVLVVPELRAMIWSSLRAFRIRRPSPLPLTEAELRTIRTPLCLLLGERSLLVHPARQAERLPRLVPTARAEIIADTGHGPNLDHAGQVNARMVAFMDAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKX0</accession>
    <name>A0A2G1XKX0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12135</name>
        <name evidence="3" type="ORF">CYQ11_03375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51821">
        <property type="protein sequence ID" value="PHQ51821"/>
        <property type="gene ID" value="BLA24_12135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12068">
        <property type="protein sequence ID" value="PPT12068"/>
        <property type="gene ID" value="CYQ11_03375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="77" mass="7901" checksum="773925105F942739" modified="2018-01-31" version="1">MRPRTGACGRARVSPPASLRSSPVRAGAPRHPEDGGPSGPRGCSSAYKLHRRTAILEGPGEAQRIDGGGGTGWRTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLM0</accession>
    <name>A0A2G1XLM0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09345</name>
        <name evidence="4" type="ORF">CYQ11_27955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52117">
        <property type="protein sequence ID" value="PHQ52117"/>
        <property type="gene ID" value="BLA24_09345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16197">
        <property type="protein sequence ID" value="PPT16197"/>
        <property type="gene ID" value="CYQ11_27955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304852" evidence="2">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="124" mass="12385" checksum="7BC976D3942A466B" modified="2018-01-31" version="1">MSVWGRVAVPQSVSRAAVALLAAVLLVLSGAASEVVGNASLRDEVPAEAPLLDLASDECAACAPEQYIPRPGRAGRPTGGRDRPPVLASAAGGAGGLSGAQAVPPRPGDAIAAADRARHFVLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM34</accession>
    <name>A0A2G1XM34_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08925</name>
        <name evidence="2" type="ORF">CYQ11_04180</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52270">
        <property type="protein sequence ID" value="PHQ52270"/>
        <property type="gene ID" value="BLA24_08925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12202">
        <property type="protein sequence ID" value="PPT12202"/>
        <property type="gene ID" value="CYQ11_04180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008868">
        <property type="entry name" value="TniB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05621">
        <property type="entry name" value="TniB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="350" mass="38110" checksum="C605920490158228" modified="2018-01-31" version="1">MNNPLADRPDDFGRYLTALPGWRAFVAASLGKPMVMLSQAEYDALVKAAQADALVKEEKNIYDEDRLDHHARLQVVATSTVRHTVACGRRLIILNRGAVSARRGLIVSGPANTGKTIALTQLGLAHELQDRRRHPGQDERIPVVYITIPPAATPRMIAAEFARFLGLPVLRRSNITDLTEAVVGVCTKARTGLILVDEIHNISLHTRTGAEASDTLKYFSERIPATFAYAGIDIEAGGLLSGTRGDQIAARFTPVDTHPFPYNAEWKSLVAQMEANLLLHQHKRGTLSRLDRFLHTRTSGMIGSLSHQLRGAAVDAILTGTEKITKAGLLAVDLDVASRRRPPGSPDTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM53</accession>
    <name>A0A2G1XM53_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00815</name>
        <name evidence="4" type="ORF">BLA24_08195</name>
        <name evidence="3" type="ORF">BLA24_10165</name>
        <name evidence="6" type="ORF">CYQ11_07825</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000108">
        <property type="protein sequence ID" value="PHQ52008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000085">
        <property type="protein sequence ID" value="PHQ52318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52008">
        <property type="protein sequence ID" value="PHQ52008"/>
        <property type="gene ID" value="BLA24_10165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52318">
        <property type="protein sequence ID" value="PHQ52318"/>
        <property type="gene ID" value="BLA24_08195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53505">
        <property type="protein sequence ID" value="PHQ53505"/>
        <property type="gene ID" value="BLA24_00815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12810">
        <property type="protein sequence ID" value="PPT12810"/>
        <property type="gene ID" value="CYQ11_07825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="40"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="285" mass="29481" checksum="BE7ACEFBC283CF06" modified="2018-01-31" version="1">MGGRAPLDGGRARCAILFALTGQYKIVGGGVDSTPHGAAITARALGVKGPRGWAFRDVDVAAPPGSLIAVQGPSGSGRTCLLLALTGRMRAAAGRAEVAGLPLPRKMAAVRRVSALAHVPGVAELDASLTVAEHLRERALLERRFNGSPRALLRPRAERAAERRSRVESALAAAGLDPGALPGGEDTAVRRLDRLQALRLSVALALIGEPRLVAVDDTDLKLSPAEREQVWELLRSLARAGTTVLAVCSEAPRDAVVVTTARAARDAGADTTKGAADAFAEAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM94</accession>
    <name>A0A2G1XM94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52336">
        <property type="protein sequence ID" value="PHQ52336"/>
        <property type="gene ID" value="BLA24_07720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="52" mass="5792" checksum="EAB99329D842E7F2" modified="2018-01-31" version="1">MDLPPRVVDPDPPPRHAAQRVGVRAWAKENGHSVNDRGRVPAEIREAYAKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMH1</accession>
    <name>A0A2G1XMH1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="6" type="ORF">BLA24_06685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52464">
        <property type="protein sequence ID" value="PHQ52464"/>
        <property type="gene ID" value="BLA24_06685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="397" mass="40791" checksum="01A0C5E57AB6E145" modified="2018-01-31" version="1">MSAAGRPSLRAERYVTETEAREAAGGRAAQLQHTGLRHGWTTGACATAATTAAYTALLTGEFPDPVTITLPKGQTPAFALAAEELGDGGRWAMAAVVKDAGDDPDVTHGALIRATVRLLPPGSGVVFRAGPGVGTVTRPGLPLAVGEPAVNPVPRQMMRDHVAEVAARYGAPGDVEIEVSVDHGEEIARSTWNPRLGILGGISILGTTGIVVPYSCSAWIDSIRRGVDVARAAGRTHVAGCTGATSEKVAVAVHGLPEDALLDMGDFAGAVLKYIRRHPVDRLTIAGGFAKLSKLAAGHLDLHSARSQVNKEFLAELARRGGAGDALAAAVASANTGLEALHLCAADGVRLGDLVAATARDEALAVLRGAPVTVDVICIDRAGTIVGRAEGRGPRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMH4</accession>
    <name>A0A2G1XMH4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07940</name>
        <name evidence="3" type="ORF">CYQ11_00375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52371">
        <property type="protein sequence ID" value="PHQ52371"/>
        <property type="gene ID" value="BLA24_07940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11573">
        <property type="protein sequence ID" value="PPT11573"/>
        <property type="gene ID" value="CYQ11_00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="110"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="264" mass="29257" checksum="4925672F7C4F772A" modified="2018-01-31" version="1">MNTTSRRRMSEQAAETAVVGACRMLRLPTIRGKFPDLAEQAAREQMSYLAFLAELLPAECDDRTRRRSERRIKAAAFPRQKSLREFDFDANPNIDAAVVHTLATCEWVKKGQPLCLIGDSGTGKSHLLIALGTEAAMAGFRVKYTLATKLVNELVEAADEKQLTKTIARYGRVDLLCIDELGYMELDGHGAELLFQVLTEREETNSVAIASNEAFGGWTKTFTDPRLCTAIVDRLTFNGTIMETGTDSYRLAQSRAKAEQATVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMI3</accession>
    <name>A0A2G1XMI3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsaD</name>
        <name evidence="8" type="ORF">BLA24_06740</name>
        <name evidence="9" type="ORF">CYQ11_26890</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52474">
        <property type="protein sequence ID" value="PHQ52474"/>
        <property type="gene ID" value="BLA24_06740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16007">
        <property type="protein sequence ID" value="PPT16007"/>
        <property type="gene ID" value="CYQ11_26890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ52474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="356" mass="36422" checksum="E22DA9EA7EC2F1B9" modified="2018-01-31" version="1">MKRSPVVLGIESSCDETGAGLVRDGQLLGQAVASSMDEHARYGGVVPEIAARAHVHAAAPVVRAALADAGLTMRDIDAVAVTTGPGLSGALQVGVAAAKGLAYSLGVPLYGVHHLAGHVAADTLEHGPLPNPCMVLIVSGGHTSLLLVRDLARDPIVHLGDTLDDAAGECFDKVARVFGLPYPGGPAVDRAAREGDPRAVAFPRPLTGPRDDPHAFSFSGLKTAAARWAEQHRAAGRALPVADGAASLQEAIADVLTRKAVGACREHGVGTLVVVGGVAANSRVRALAQERCDAAGIELRVPPLRLCTDNGAMIAAVGYLLVRAGAEPAPLDVSIDPSAPLEYAALHPVTRIVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMM1</accession>
    <name>A0A2G1XMM1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000083">
        <property type="protein sequence ID" value="PHQ52421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52421">
        <property type="protein sequence ID" value="PHQ52421"/>
        <property type="gene ID" value="BLA24_07570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="215" mass="24248" checksum="E9AFAC88752E9576" modified="2018-01-31" version="1">MLYLWLIDDTIVHTPQARRAWRTHARATGQTTAVRRGKNVRAIVEQLAHPSATLKQRRVAQLVLEEGERTGRIDIGKLTAVLTELYSPWPVQPGMPRIERALPGPFGPVSVQHHIAMWKAREQTFRRLRHEEIDENELDRVRAVYRPMWADYQARRPAMATIGDGEFAAYFAEPDTMEGRAIKAVDAFVGTLAGELGLIEAAAHAAETARLRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMR2</accession>
    <name>A0A2G1XMR2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07150</name>
        <name evidence="2" type="ORF">CYQ11_27305</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52542">
        <property type="protein sequence ID" value="PHQ52542"/>
        <property type="gene ID" value="BLA24_07150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16080">
        <property type="protein sequence ID" value="PPT16080"/>
        <property type="gene ID" value="CYQ11_27305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="6562" checksum="DF78E04FF15F6113" modified="2018-01-31" version="1">MAVSISVVLLLLVLAVVFMRSGGLKFAHALVCVLLGFLLASTSVAPTISHGLSATTQLVGDVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMT7</accession>
    <name>A0A2G1XMT7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07275</name>
        <name evidence="3" type="ORF">CYQ11_27430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52562">
        <property type="protein sequence ID" value="PHQ52562"/>
        <property type="gene ID" value="BLA24_07275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16100">
        <property type="protein sequence ID" value="PPT16100"/>
        <property type="gene ID" value="CYQ11_27430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="146" mass="16219" checksum="AEDB09DA2500CCEF" modified="2018-01-31" version="1">MTAPDTSGHLTEQLLRLTRRLHRAQKRYLDPVGITPAQSRLLRTVAHYETPPRMADLAQHLEVVPRAVTTLVDALEANGAVRRVPDQSNRRVIRIELTDQGRSTLRALREARLAAVEDILAPLSAEQRDVLAGLLTELLTGPDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN58</accession>
    <name>A0A2G1XN58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoenolpyruvate--carbohydrate phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_06265</name>
        <name evidence="4" type="ORF">BLA24_12425</name>
        <name evidence="6" type="ORF">CYQ11_04300</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000139">
        <property type="protein sequence ID" value="PHQ51668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000075">
        <property type="protein sequence ID" value="PHQ52650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51668">
        <property type="protein sequence ID" value="PHQ51668"/>
        <property type="gene ID" value="BLA24_12425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52650">
        <property type="protein sequence ID" value="PHQ52650"/>
        <property type="gene ID" value="BLA24_06265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12222">
        <property type="protein sequence ID" value="PPT12222"/>
        <property type="gene ID" value="CYQ11_04300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="149" mass="15379" checksum="5A52ACBA502A88F7" modified="2018-01-31" version="1">MTTVTSPIAGRAIGLAAVPDPVFSGAMVGPGTAVDPIREPHAAVSPVDGVIVSLHPHAFVVVDSEGHGVLTHLGIDTVQLNGEGFELLVNKGDTVSRGQEVVRWNPAAVEEAGKSPVCPIVALEATADSLADLREDGDLKAGDQLFSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN96</accession>
    <name>A0A2G1XN96_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_05430</name>
        <name evidence="5" type="ORF">CYQ11_01890</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52717">
        <property type="protein sequence ID" value="PHQ52717"/>
        <property type="gene ID" value="BLA24_05430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11811">
        <property type="protein sequence ID" value="PPT11811"/>
        <property type="gene ID" value="CYQ11_01890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304740" evidence="2">
        <location>
            <begin position="43"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="233" mass="24440" checksum="70BF930C0BA7E07D" modified="2018-01-31" version="1">MRSTHSGYTRLSKVHKFSAAGLTAAAAATVVFAAVSGGTASAAEAHAVKPVAWSAGSFGETQQDELAKQVDAAAKQAKADAAAKKADAGVKAKAEQERASRSEARKPMKPAAAKPAAKPAAPAKKAYADNLDGWIRQSLDILHAKGVPASYEGIKRNIMRESTGNPRAINDWDVNAVNGVPSKGLLQIIDPTFKAYHVEGTSWDIWDPVANITASCNYAADKYGSMDNVNSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNA9</accession>
    <name>A0A2G1XNA9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000078">
        <property type="protein sequence ID" value="PHQ52639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52639">
        <property type="protein sequence ID" value="PHQ52639"/>
        <property type="gene ID" value="BLA24_06370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="76" mass="8227" checksum="70417892F3A25D06" modified="2018-01-31" version="1">MPHFAVHEGYAVYEGPATDSSFHMHAAFQVAIAVRGEVLMVDASGTRHQAVALIVRRWCGIAERGAVPGSRSRLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNB2</accession>
    <name>A0A2G1XNB2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Twin-arginine translocation pathway signal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_05595</name>
        <name evidence="2" type="ORF">CYQ11_02055</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52744">
        <property type="protein sequence ID" value="PHQ52744"/>
        <property type="gene ID" value="BLA24_05595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11840">
        <property type="protein sequence ID" value="PPT11840"/>
        <property type="gene ID" value="CYQ11_02055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="152" mass="17010" checksum="94B570AEF5702547" modified="2018-01-31" version="1">MTDHRFVPDDFVVPSGLTGRGFRLEPLGPEHNAADHAAWTSSIGHIRGTAGFEQRGWPPAAGMSLAENLRDLERHAGDFARRAGFTYTVLDDDGTVVGCLYIYPSHADPQVTEVRSWVCADRAELDEPLFEAVKRWLASDWPFRDVRYRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNW7</accession>
    <name>A0A2G1XNW7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_05090</name>
        <name evidence="4" type="ORF">CYQ11_28440</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52928">
        <property type="protein sequence ID" value="PHQ52928"/>
        <property type="gene ID" value="BLA24_05090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11411">
        <property type="protein sequence ID" value="PPT11411"/>
        <property type="gene ID" value="CYQ11_28440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304982" evidence="2">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT11411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="7893" checksum="6CF71D3F4C80BE33" modified="2018-01-31" version="1">MTGACALAAAAPASANFIGDNMALAQIASQQTGVNSGNQQSTSNHGSNNGNTAQQGVSDNQDVDVIKNIAGFNNPVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP52</accession>
    <name>A0A2G1XP52_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_04760</name>
        <name evidence="8" type="ORF">CYQ11_28775</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52971">
        <property type="protein sequence ID" value="PHQ52971"/>
        <property type="gene ID" value="BLA24_04760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11515">
        <property type="protein sequence ID" value="PPT11515"/>
        <property type="gene ID" value="CYQ11_28775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT11515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="263" mass="27780" checksum="332BC356BA6F3A34" modified="2018-01-31" version="1">MLYAYAVTRDDEAVTEALATVTGVVGEPVRAVRHEGLLALVGPVPAAQYDEGALRANLEDLAWLERTARAHQRVIDAVAAAAPCVLPLRLATVYREERGVHGMLAAGGPRLGAALDRLEGRAEWGVKVHTLPQGPPAAGPPPSAPRAPASGRDYLRQRAAQRRAHEGRSRQADEAARGIHTALTALAEETRLYPAQNAGLSRQPGHNVLNAAYLVPGAARTRFTSAVARLAESAPAEGVRVELTGPWAPYSFVGPVTEDPGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP56</accession>
    <name>A0A2G1XP56_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">BLA24_04205</name>
        <name evidence="14" type="ORF">CYQ11_14055</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53028">
        <property type="protein sequence ID" value="PHQ53028"/>
        <property type="gene ID" value="BLA24_04205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13864">
        <property type="protein sequence ID" value="PPT13864"/>
        <property type="gene ID" value="CYQ11_14055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="478"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT13864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="594" mass="65192" checksum="A283956D30499381" modified="2018-01-31" version="1">MASVPSLASTLHQRIADALSAALPEAGAADPLLRRSDRADFQANGMLALAKKLKGNPRELAAKVVESLPVGEGLLMQEIEVSGPGFLNITVSDKAITETLAARAADDRLGVPFKEHPGTTVIDWAQPNVAKEMHVGHLRNTVIGNSVVRLLEFTGEKVVSRHHIGDWGTQFGMLIQYLIEHPHELDHKAAEDGPAVSGEEAMSNLNRLYKASRALFDADGEFKTRARRRVVDLQAGDPETIALWQKFVDESKIYFYSVFGKLDVEIRDEDIVGESGYNDMLAETCRMLEESGVAVRSEGALCVFFDDVKGPDGNPVPLIVQKSDGGFGYAATDLSAIRDRVFNLKADTLLYVVDVRQSLHFKMVFETARRAGWLTDDVKAVQLGFGTVLGKDGKPFKTREGETVRLVDLLDEAIGRATDVVREKAEKVGLSEQEIVENGEYVGIGAVKYADLSTSAARDYKFDLDQMVSLNGDTSVYLQYAYARIRSIVRRAGEAKPVAHPELSLAPAERALGLHLDQFAATVAEAAGEYAPHKLAGYLYQLASFYTTFYDQCQVLSEDNAPELVENRLFLCDLTARTLREGMALLGIRTPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP88</accession>
    <name>A0A2G1XP88_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aroA</name>
        <name evidence="11" type="ORF">BLA24_03890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000056">
        <property type="protein sequence ID" value="PHQ53065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53065">
        <property type="protein sequence ID" value="PHQ53065"/>
        <property type="gene ID" value="BLA24_03890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="407" mass="42377" checksum="BE8B82890CB25E61" modified="2018-01-31" version="1">MTESTAHTDLWPAPVATAAVDATVTVPGSKSVTNRGLVLAALAAEPGWLRRPLRSRDTVLMADALRAMGVGIEEGVGPDGTGEAWRVIPARLHGPASVDVGNAGTVMRFLPPVATLADGPVRFDGDPRSYERPLHGVIDSLRALGARIEDNDRGALPLTVHGAGALDGGPVEIDASSSSQFVSALLLSGPRFNQGVEVRHVGAALPSLPHIRMTVDMLRMAGAQVDTPESGGEPDVWRVSPSALLGRDLVVEPDLSNAAPFLAAALVTGGRVTIPDWPEHTTQPGDALRGIFTDMGGACELTDAGLTFTGTGRVTGIDADLHEVGELTPVIAAVAALADSESVLRGIAHLRLHETDRLAALAKEINELGGDVTETEDGCASAARRRRSPTYGDHRLATAAAARPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPL4</accession>
    <name>A0A2G1XPL4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03265</name>
        <name evidence="4" type="ORF">BLA24_03280</name>
        <name evidence="2" type="ORF">BLA24_20555</name>
        <name evidence="5" type="ORF">CYQ11_10225</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000039">
        <property type="protein sequence ID" value="PHQ53131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000039">
        <property type="protein sequence ID" value="PHQ53132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50005">
        <property type="protein sequence ID" value="PHQ50005"/>
        <property type="gene ID" value="BLA24_20555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53131">
        <property type="protein sequence ID" value="PHQ53131"/>
        <property type="gene ID" value="BLA24_03265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53132">
        <property type="protein sequence ID" value="PHQ53132"/>
        <property type="gene ID" value="BLA24_03280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13217">
        <property type="protein sequence ID" value="PPT13217"/>
        <property type="gene ID" value="CYQ11_10225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="10"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="33380" checksum="14EB6D337A3AE101" modified="2018-01-31" version="1">MGVTAALLAVDAGNSKTDVTLVDTGGRVLASARGGGFQPVRTGTGPAVADLARIVAEVVERAAPCGAPRVAHVQACLANADLPVEEERLTAEIAAQGWAPSVTVVNDTFALLRAGLPDGGEPTGVAVVCGAGINCAGLAPGGRTARFPALGRISGDWGGGGYLAEEALWLAARAADGRGEATALSAALPAHFGLAGMAELVEALHLGHVPWEDRYRLTPVLFAVAAAGDEVARTVVVRQAEEVVTMATTALARLDLLEHEVPVVLGGGVLAAGHRLLHERIGALLARRAPLAVPRVVTAPPVLGAALLALDHAGAPETAHARLRAHYAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ00</accession>
    <name>A0A2G1XQ00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF948 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_02815</name>
        <name evidence="3" type="ORF">CYQ11_05110</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53261">
        <property type="protein sequence ID" value="PHQ53261"/>
        <property type="gene ID" value="BLA24_02815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12355">
        <property type="protein sequence ID" value="PPT12355"/>
        <property type="gene ID" value="CYQ11_05110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="143" mass="14954" checksum="A89088A043464ACB" modified="2018-01-31" version="1">MAGILVAVFWAILVSFIALVLVRLAQTLKAATRLVSEISEQAVPLLADASATVRSANTQLARVDSITADVQEVTANASALSSTVSSAFGGPLVKVAAFGYGVRRAIGRKTEPAERESTVFAGRTVDSRLPSARRGGRRTRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQI5</accession>
    <name>A0A2G1XQI5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="13" type="ORF">BLA24_00765</name>
        <name evidence="14" type="ORF">CYQ11_07775</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53496">
        <property type="protein sequence ID" value="PHQ53496"/>
        <property type="gene ID" value="BLA24_00765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12801">
        <property type="protein sequence ID" value="PPT12801"/>
        <property type="gene ID" value="CYQ11_07775"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="169"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="392"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="467"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="467"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="171"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PHQ53496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PPT12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="565" mass="58366" checksum="7C27FCC3AA1BFCBC" modified="2018-01-31" version="1">MTTITPGPGNHGPARPSLRDEEGAPGTLTAVPHADQSPNPPKDTPVVTPGAPRPTQVRPVPLAELAGQLGIPAPQGAEAAATGITHDSRAVRPGDVYAALPGARFHGADFAAQAAGLGAVAVLTDPAGAERAAATGLPVLVVDDPRGHMGALAAAVYGDPGADLLQIGITGTSGKTTTAYLIEGGLRALAGPTGLIGTVESRIGDEALKSERTTPEATDLQALFAVMRERGVRSVAMEVSSHALRLGRVDGCVFDVAVFNNLSPEHMEFHSGMEDYFAAKAELFTKERSRLGVVNLDDEYGRRLARGESEVPVVTFSAEGREDADWRAVDVEIGPFDSTFTVLGPEGRSVTARAPLAGPFNVANALAAIVALVAAGADPQAAADGVAAVPGVPGRLERVDAGQPYLAVVDYAHKTDAVESVLRALREVGTGRVHAVLGCGGDRDTTKRAPMGRALARLADTAVLTSDNPRSEDPLAILATMLSGAVEVPPAERGTVLLLEDRAAAIAAAVARAEPGDTVLVLGKGHEQGQDVAGVVRPFDDRRVLREAIEAERARSSTKHRNDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQJ1</accession>
    <name>A0A2G1XQJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00810</name>
        <name evidence="1" type="ORF">BLA24_08215</name>
        <name evidence="3" type="ORF">CYQ11_07820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000085">
        <property type="protein sequence ID" value="PHQ52319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52319">
        <property type="protein sequence ID" value="PHQ52319"/>
        <property type="gene ID" value="BLA24_08215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53504">
        <property type="protein sequence ID" value="PHQ53504"/>
        <property type="gene ID" value="BLA24_00810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12809">
        <property type="protein sequence ID" value="PPT12809"/>
        <property type="gene ID" value="CYQ11_07820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="26058" checksum="3199347406580EFB" modified="2018-01-31" version="1">MSDPLRPRASLRTAVVWEVLRDALDRRVKAAGRDALEVLDTGGGSGKFAVPLARLGHRVTVVDPSPNALFALERRAAEAGVADLVRGVQGDAHGLFDVVERDGYDLVLCHGVLEYVEDPAESVRNAVAALRPSGTLSLLAAGLGGAVLARALAGHFTEARQALADPAGQWGAGDPLTRRFTAEQLSGLVTDAGLAVTAVHGVRVFADLVPGVLVDAEPGAIDALLRLEAAAAEVPAFHSVATQLHVLAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQK9</accession>
    <name>A0A2G1XQK9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00805</name>
        <name evidence="4" type="ORF">CYQ11_07815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53503">
        <property type="protein sequence ID" value="PHQ53503"/>
        <property type="gene ID" value="BLA24_00805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12808">
        <property type="protein sequence ID" value="PPT12808"/>
        <property type="gene ID" value="CYQ11_07815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="130" mass="14596" checksum="5424B9A5E9C1804F" modified="2018-01-31" version="1">MPLSEHEQRMLEQMERALYAEDPKFATALEGSGLRTYTRRRVYQAVAGFLAGIALLMAGMVAQRIWISVAGFLVMLACAVLAVTGWRKAPRPGAQRGAGPGGTPRRQAGRRSMMDRIEQRWQRRRDEQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQQ1</accession>
    <name>A0A2G1XQQ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_00675</name>
        <name evidence="7" type="ORF">CYQ11_07685</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53479">
        <property type="protein sequence ID" value="PHQ53479"/>
        <property type="gene ID" value="BLA24_00675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12784">
        <property type="protein sequence ID" value="PPT12784"/>
        <property type="gene ID" value="CYQ11_07685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="367" mass="39901" checksum="6F3FDBB4DDB52BBA" modified="2018-01-31" version="1">MEDVLRPLAVVGGALLVTLLVGWLADRIVRGIAERRPDDPLWGLLRRCRMPLRLVLCAALLRGGYSSAELGEKHEAVIGQGLTLVLIGACAWLAVRLATAVVEAGYARYAAGARDPARMRRVRTQVTLIRRVVTAAVAVVAVAAMLLTFPAMRTVGTSLLASAGLIGIVAGVAAQSTLGNLFAGLQIAFGDMVRIGDTVVVGGEWGTVEEITLTYLVVATWDERRITMPVSYFTSRPFENWSRGNARMTGTVFFHLDHAAPVDLLRERLHQVLKATLEWDGRAWSLVVTDTTPSTIQVRALMTAQNSDDIWALRCVVREELVSWLRREHPYALPRFNTAPAPGLEEAPDRRQTPPTSEDVAPGPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9C4</accession>
    <name>A0A2G1X9C4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ORF">BLA24_30440</name>
        <name evidence="15" type="ORF">CYQ11_23535</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47834">
        <property type="protein sequence ID" value="PHQ47834"/>
        <property type="gene ID" value="BLA24_30440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15459">
        <property type="protein sequence ID" value="PPT15459"/>
        <property type="gene ID" value="CYQ11_23535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PHQ47834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PPT15459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="233" mass="24978" checksum="B5B607AFCCAD0DEF" modified="2018-01-31" version="1">MPYQPPTHSVERSIRATTGAKIVAGVDEVGRGAWAGPVTVCAAITGLRRAPDGLTDSKLLTPKRRTALAGELEAWVTAYALGHSSPEEIDELGMTAALRLAATRALEGLPVRPDAVILDGKHDYLGDPWKVRTVIKGDQSCVVVAAASVIAKVRRDAMMAELGADHADFGFCDNAGYPSPVHRAALEELGPTAHHRLSWAYLDALPRWQHLKRARLTPDTMALEAGGQLGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9G1</accession>
    <name>A0A2G1X9G1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_30590</name>
        <name evidence="6" type="ORF">CYQ11_23685</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47858">
        <property type="protein sequence ID" value="PHQ47858"/>
        <property type="gene ID" value="BLA24_30590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15483">
        <property type="protein sequence ID" value="PPT15483"/>
        <property type="gene ID" value="CYQ11_23685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="720"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ47858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="938" mass="99201" checksum="E1C8339CF23E5729" modified="2018-01-31" version="1">MQMPPEHVYPAHWEADVVLRDGGTAQIRPIAPDDAQRLVSFYEQVSDESKYYRFFAPYPRLSDRDVHRFTHHDYVDRVGLAATVGGEFIATVRYDRIDARGLPASSPADEAEVAFLVQDAHQGRGVASALLEHIAAVARERSIRRFAAEVLPANTKMIKVFTDAGYTQKRSFEDGVVRLELDLEPTDRSLAVQRAREQRAEARSVRRLLAPGSVAVVGTGREPGGMGRTVLRNLLAGGYTGRVYAVNRAFPEGPSTLEPEGVPAHRSVLGIEDPVDLAVVAVPAAQVPSVVADCGEHGVQGLVVLSAGYAESGQEGRDRQRELVRQARSYGMRLIGPNAFGLINTAAGVRLNASLSPELPAAGRVGLFSQSGAIGIALLGGLHRRAAGLVGISTFVSAGNRADLSGNDFLQYWHDDPDTDVALMYLESLGNPRKFTRLAKRTAARKPLVVVKGARHGAVAAPTGHAVPTTRIPDATVSDLLRQAGVIRVDTVTELADVGLLLASQPLPAGPRVAILGNSESLALLTYDAVLTEGLRPQPPRDLTTAAAPADFRAALAEALADRSCDAVVVTAIPWVGDASAADLAAALREAVARSRAAKPVSVVHLEIPGLAEALAAPLPDEGGPAESRPEAGGEAAEAPAPAVRIPAYPAAERAVRALAEAVRYAQWRRQAADPGRVPEYEDIDEAGAAADIGVLLEAHGATPGTGPRRAVTLSAADTQRLLARYGIAVLPALPAPDPDGAVRAARRLGFPVALKPTAPHLRHRADLGGVRLDLGTESELRRAYAELTELLGKPEETRLVVQSMAPRGVDTVVRAAIDPAAGAVLSFGLAGAPSLLLGDTAHRLVPATDRDVSDLIRSIRTAPLLFGWRGSTPVDTPALEELLLRVSRLVDDHPEVVGADLEPVIVAPHGVHILGASIRLAPPPARTDLGPRSLPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9P6</accession>
    <name>A0A2G1X9P6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31270</name>
        <name evidence="2" type="ORF">CYQ11_24310</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47946">
        <property type="protein sequence ID" value="PHQ47946"/>
        <property type="gene ID" value="BLA24_31270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15570">
        <property type="protein sequence ID" value="PPT15570"/>
        <property type="gene ID" value="CYQ11_24310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046081">
        <property type="entry name" value="DUF6099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19594">
        <property type="entry name" value="DUF6099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="152" mass="15768" checksum="6927E1B04A8A7124" modified="2018-01-31" version="1">MDAARLIEVTRHALARAGAVEDIVVEAWQAQALAEAVGSHLAAHGPFEVRAAARGLSEAGGRASGALCRIALRAGGLRAAQLGEVRDPWSALTDLGDLLGEVGIALVGVACACEEDAVYWQCIEAIDAADETSDRISGLLRRLTLRERGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9W8</accession>
    <name>A0A2G1X9W8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31775</name>
        <name evidence="2" type="ORF">CYQ11_24830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48034">
        <property type="protein sequence ID" value="PHQ48034"/>
        <property type="gene ID" value="BLA24_31775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15660">
        <property type="protein sequence ID" value="PPT15660"/>
        <property type="gene ID" value="CYQ11_24830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="58" mass="6218" checksum="D41A3C85067BE380" modified="2018-01-31" version="1">MSERAAPFHCPYCGDEDLRPGEQGHGAWECGACNRAFKLSFLGLLARGLTKGADHDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA47</accession>
    <name>A0A2G1XA47_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32130</name>
        <name evidence="3" type="ORF">CYQ11_25190</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48092">
        <property type="protein sequence ID" value="PHQ48092"/>
        <property type="gene ID" value="BLA24_32130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15718">
        <property type="protein sequence ID" value="PPT15718"/>
        <property type="gene ID" value="CYQ11_25190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="208" mass="21181" checksum="71EEB51EFE097311" modified="2018-01-31" version="1">MTSTVNARTGRAPVAGLLLAAGGGRRLGGRPKALLPHRGGLLVEHALRVLREGGCGPVHVVLGAGAEKVRARLGPAAGVVLVDHPGWADGMGTSLRAGLASLTAAGTDASAALVALVDQPRVGARAVARVLAAHREGAELAAAAYEGVRGHPVLLAREHWDGVARAATGDRGARDYLRQHASLVRLVECSDVAAPDDVDTPDDLALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAS1</accession>
    <name>A0A2G1XAS1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BLA24_33520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48320">
        <property type="protein sequence ID" value="PHQ48320"/>
        <property type="gene ID" value="BLA24_33520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1018"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2560"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4084"/>
            <end position="4163"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="5610"/>
            <end position="5685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3086"/>
            <end position="3112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3093"/>
            <end position="3112"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1053"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2595"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="4123"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="5645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="5768" mass="602975" checksum="50C97874796276F7" modified="2018-01-31" version="1">[encoded data, 5768 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAX4</accession>
    <name>A0A2G1XAX4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_32265</name>
        <name evidence="10" type="ORF">CYQ11_25320</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48365">
        <property type="protein sequence ID" value="PHQ48365"/>
        <property type="gene ID" value="BLA24_32265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16791">
        <property type="protein sequence ID" value="PPT16791"/>
        <property type="gene ID" value="CYQ11_25320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="223"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT16791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="428" mass="45766" checksum="88ECDD4A87565DA5" modified="2018-01-31" version="1">MVVLTVAFNTVVRHHLARQADDELRTRAAAVATTVDTGSRPVRVRETADDALLDTNVWIYAEKRLLEHPASAPEGSRLTRTAAGLATYGSGRCTTFQGDTPVRLCGRPVGDGPPGSPPRAVVVTALDLSLYRASADTMLLASLALGTAVLACTYALTRLAVGRALHPVHVMTDQATRWSSVASDERFSATARPVELSRLGASLDGLLDRIRAVLRHEQQLTRELSHELRTPLARIIAELDWWQARPRSTADTRATHARLADAARCMRTICDTLLHDARDGARTAPGTAGVPPVLRDLVDRLPGNERAKVTVTCPEELTVGVSAALLERVVSPLLDNALRYARSRVLISAAHRPGGVFVEIADDGPGVPHSFTAHLFQPGRRAAADDGHDGAGLGLPLARRLARSAGGDVRHEVRRTPGAAFVISLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB33</accession>
    <name>A0A2G1XB33_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28940</name>
        <name evidence="3" type="ORF">CYQ11_06535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48411">
        <property type="protein sequence ID" value="PHQ48411"/>
        <property type="gene ID" value="BLA24_28940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12594">
        <property type="protein sequence ID" value="PPT12594"/>
        <property type="gene ID" value="CYQ11_06535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041065">
        <property type="entry name" value="GNAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18407">
        <property type="entry name" value="GNAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GNAT_like" evidence="1">
        <location>
            <begin position="290"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="343" mass="35202" checksum="1E7E4239842E7730" modified="2018-01-31" version="1">MNQTARTRPDGSEQRLSDAYDTALLDLDGVVYAGGVAIAHAVESLGAAREGGMHLAYVTNNAARTPATVAGHLTELGIPADPSDVITSAQAVARLIADQVPAGSKVLVVGAEGLRVALRERGLVPVESADDDPAAVVQGYGGPDMPWSRLAEASYAVARGVPWFASNTDLTIPSERGIAPGNGSAVEVVRIATGGDPQVAGKPQPPMHRETILRTGAERPLVVGDRLDTDIEGAHVGGVDSLLVLTGVTTAAQLIAARPEHRPTYVAEDLRGMLQGQPVVSGSAEEGFRCGGWTASADGRALTLDGEGERIDALRALCGAAWASAGEGSCGLDAGKALSRLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBH9</accession>
    <name>A0A2G1XBH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_29780</name>
        <name evidence="2" type="ORF">CYQ11_05695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48604">
        <property type="protein sequence ID" value="PHQ48604"/>
        <property type="gene ID" value="BLA24_29780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16364">
        <property type="protein sequence ID" value="PPT16364"/>
        <property type="gene ID" value="CYQ11_05695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="246" mass="26432" checksum="D0B908440FE82440" modified="2018-01-31" version="1">MSGRPAVRRVVSLVPSLTEAVAVTEPGLLVGATNWCEEPAGLDVVRIGGTKNPDVARVVALAPDLVVANEEENRAPDLAALRAAGLDVMVTGIRTLDQAFRELERVLVRGCGLRPPAWLSDARDAWRDVSAPGPLLRAVVPVWRRPWMVLGSDTFAGDLLARLGVANVHAGHAERYPRVPLDELNACGAELVVLPDEPYRFTRDDGPEAFPGLPCALVSGRHLTWYGPSLTRAPQVLAAALRAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBI7</accession>
    <name>A0A2G1XBI7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_01480</name>
        <name evidence="1" type="ORF">BLA24_28260</name>
        <name evidence="3" type="ORF">CYQ11_07210</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000024">
        <property type="protein sequence ID" value="PHQ53384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48617">
        <property type="protein sequence ID" value="PHQ48617"/>
        <property type="gene ID" value="BLA24_28260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53384">
        <property type="protein sequence ID" value="PHQ53384"/>
        <property type="gene ID" value="BLA24_01480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12703">
        <property type="protein sequence ID" value="PPT12703"/>
        <property type="gene ID" value="CYQ11_07210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="87" mass="9513" checksum="6D562150522EC9BF" modified="2018-01-31" version="1">MCVLFTLCLGHLLPCRTNRLDMFAQRVGVGPDAHGLTKTDTPGEDLSCHFPEDVVVSSGRQVLKGFVHDLGLRMVTPPAQELLVAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBP5</accession>
    <name>A0A2G1XBP5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">BLA24_28410</name>
        <name evidence="10" type="ORF">CYQ11_07060</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48642">
        <property type="protein sequence ID" value="PHQ48642"/>
        <property type="gene ID" value="BLA24_28410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12679">
        <property type="protein sequence ID" value="PPT12679"/>
        <property type="gene ID" value="CYQ11_07060"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="210"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="507" mass="57035" checksum="EE08DF11AB6C3EDE" modified="2018-01-31" version="1">MSSSNPLRDASDRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLIGFARRSWVDEDFAEEVYNAVKQHSRTPFREEVWQQLVQGCRFVEGDFDDDEAFDTLRKTIEELDQAQGTGGNFAFYLSVPPKFFPQVVQQLKKHGLAEQKEGTWRRAVIEKPFGHDLKSAQELNRIVHEVFPAEAVFRIDHYLGKETVQNILALRFANTLFEPIWNRSYVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPASFDADAVAAEKTKVLGAVRLPKDLGKETVRGQYAHGWQGGEQVVGYLQEEGIDPQSKTDTYAAVKLEIDNRRWAGVPFYLRTGKRLGRRVTEIAVVFQRAPYSPFDQTATEELGQNALVIRVQPDEGVTVRFGSKVPGTSMEVRDVSMDFAYGESFTESSPEAYERLILDVLLGESNLFPRLKEVELSWQILDPIEVYWDKHGKPAQYPAGTWGPVEADEMLARDGRSWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBT2</accession>
    <name>A0A2G1XBT2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">BLA24_28600</name>
        <name evidence="12" type="ORF">CYQ11_06865</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48670">
        <property type="protein sequence ID" value="PHQ48670"/>
        <property type="gene ID" value="BLA24_28600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12649">
        <property type="protein sequence ID" value="PPT12649"/>
        <property type="gene ID" value="CYQ11_06865"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="323" mass="33302" checksum="85D15BA7086EB88D" modified="2018-01-31" version="1">MPFCGFACGTALGYLADLVFGDPRRGHPVAAFGRAAHAVEQRLWRDHRGHGALHTLVCAGGAVAGAGLLARAVRGRRAPGVALTAAATWAVLGGTSLGREARAIGGALAAGDIEVARERLPHLCGRDPQALDGQQIARAVVESVAENTSDAVVGALFWGALGGVPGLAGFRAVNTLDAMVGHKSPRHRRFGWASARLDDVVGWPGARLTAALTVLAGPDPRGAWRVARRDASRHPSPNAGPVEAAFAGALGVRLGGTLAYAGRVEHRPVLGAELRPVRVADIERAVRLSRRVSLLAVGTAIGGRALGSLVKSAAASAARRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBU4</accession>
    <name>A0A2G1XBU4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_01490</name>
        <name evidence="10" type="ORF">BLA24_28270</name>
        <name evidence="12" type="ORF">CYQ11_07200</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000024">
        <property type="protein sequence ID" value="PHQ53389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48724">
        <property type="protein sequence ID" value="PHQ48724"/>
        <property type="gene ID" value="BLA24_28270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53389">
        <property type="protein sequence ID" value="PHQ53389"/>
        <property type="gene ID" value="BLA24_01490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16405">
        <property type="protein sequence ID" value="PPT16405"/>
        <property type="gene ID" value="CYQ11_07200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ48724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="184" mass="18924" checksum="D4E3BB6C278D3C0E" modified="2018-01-31" version="1">MPPPGPRPWAWTTIDTPVGPLGLAATAQGLLSVVFRADAGTAATAVARLTQQLGSPPCPPPSPCNGLLAEASAQLGDYFAGRLRTFSVPLDWSLTSGFNRRALRELLAHVPYGALAAYQDLADRTGEPGAARAVGVAMGSNPLPIVVPCHRVVESGGGLGGFGPGLEIKRALLALEGVLPEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBY1</accession>
    <name>A0A2G1XBY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28515</name>
        <name evidence="4" type="ORF">CYQ11_06955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48732">
        <property type="protein sequence ID" value="PHQ48732"/>
        <property type="gene ID" value="BLA24_28515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16397">
        <property type="protein sequence ID" value="PPT16397"/>
        <property type="gene ID" value="CYQ11_06955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758470" evidence="1">
        <location>
            <begin position="36"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="313"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="613" mass="65217" checksum="8F1EBA40CE4201BF" modified="2018-01-31" version="1">MPTDRPAHRRTTATGFLIAGALAAGLVTPAQSASAADGSGVRIHDIQGTTRVSPLAGQQVRDVPGVVTAVKAFGSARGFWFQDPDPDHDAATSEGVFVFTGTTTPAVAPGDSVLVSGTVGEYYPGGEAAGLQSVTQLTKATWTVRSSGNPLPAAVRLTSSAVPARYAPDAHGGSIEKLPLKPGRYALDRYESLEGMRVEVRDAAVVGATNEHKELWVTADPRHDRTRRGGTLYGAYDDPNSARVKVASLIPFAQHPFPVADVGDALTGTTAGPLDYDNFGGYTLQATELGTLADHELARETTRKQRSDELAVATYNVENLSPKTPQAKFDRLAAALVTNLASPDVVALEEVQDDDGTVNDGVVDAGQTLKKLTDAIAAAGGPAYQWRQISPVNNQDGGQPGGNIRTAFLFNPARVSFKDVPGGDATTPVKVTRENGKAALSASPGRVAPADAAWTNSRKPLAGQFSFRGRDVFVVANHFNSKGGDQGLDSRFQPPARSSEIQRTQQAQLVNGFVKQLLAADKHANVIVAGDLNDYQFSPALKALTAGCVLTDQVDRLPKKERYGYVYQGNSQVLDHMLTSRHIGRVDYDIVHINAEFADQASDHDPQVLRWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBZ8</accession>
    <name>A0A2G1XBZ8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28645</name>
        <name evidence="3" type="ORF">CYQ11_06820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48738">
        <property type="protein sequence ID" value="PHQ48738"/>
        <property type="gene ID" value="BLA24_28645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16390">
        <property type="protein sequence ID" value="PPT16390"/>
        <property type="gene ID" value="CYQ11_06820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="1">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="86" mass="9328" checksum="A5A256AAF10E5B9A" modified="2018-01-31" version="1">MRVKRRISHEEARVAETLKKGSRVTGAAREKLAADLKRKYDSGASIRALAEETGRSYGFVHRMLSESGVILRGRGGATRGKKAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC05</accession>
    <name>A0A2G1XC05_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27230</name>
        <name evidence="4" type="ORF">CYQ11_18425</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48773">
        <property type="protein sequence ID" value="PHQ48773"/>
        <property type="gene ID" value="BLA24_27230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14579">
        <property type="protein sequence ID" value="PPT14579"/>
        <property type="gene ID" value="CYQ11_18425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="26564" checksum="574BB8F56558572C" modified="2018-01-31" version="1">MPDRRRHAAHRPPLPAAIALRGRQSPPSNATGSEDQRDNPFAAPPEGRPDRPWQPRQPQPPAGDGDGDGEGGSGQQPPAWGSQWSNRQPGRQDGGFGGQGGGPGGPNPSGGGPGGGLRWDPTDPAQRRARYALLAGMWGFFFALFSIPQVALLLGALSVYWGISALRAKSKPRDPDTPAPAPTAGGFRPQTTAAVSGLVTGGLALAIVAATFTVHLVYRDYYTCVDDALTQTSLQSCENHLPKQLRPLLGSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC40</accession>
    <name>A0A2G1XC40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM zinc finger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27265</name>
        <name evidence="4" type="ORF">CYQ11_18390</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48778">
        <property type="protein sequence ID" value="PHQ48778"/>
        <property type="gene ID" value="BLA24_27265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14573">
        <property type="protein sequence ID" value="PPT14573"/>
        <property type="gene ID" value="CYQ11_18390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="462" mass="48062" checksum="51822AEDC479CA99" modified="2018-01-31" version="1">MNPQGERWTAEQVLALAPDAASRKAGAKLAAPGPWSGPGAHTDGGVGAVWGECAGSGSKPYRTVVDLAGQGGPGFHCSCPSRKFPCKHALGLLLLWTEGPAAVPAADAPPDWAGQWLERRRGRAERADSEAGAVGGATAPVDTEAARRRAERRAGRIATGASELEQRLSDLLRGGLAAVEGARYGQWEETAARMVDAQAPGLAAWVRELASLAGSGAGTDWASRMLEECALLHTLSQGYLRVEELPEALAATVRSRVGISTDAAALLAAGPLVRDHWLVLAQRDSDDGRLTTRRIWLHGRETGRMALLLSYGAAGRAPELSLPVGLALDADLAFHPSARPLRAVLGTRHGAPEPCPAPPPGGDARDALRAYGDALRGDPWLEAWPVVLSSVIPVPGDGGRRWHMSDVEGESALPVASRGGGDGTGLWQLAAISGGGPVTVFGECGHRGFTPLATWAPEPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC57</accession>
    <name>A0A2G1XC57_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27615</name>
        <name evidence="3" type="ORF">CYQ11_18025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48837">
        <property type="protein sequence ID" value="PHQ48837"/>
        <property type="gene ID" value="BLA24_27615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14517">
        <property type="protein sequence ID" value="PPT14517"/>
        <property type="gene ID" value="CYQ11_18025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="136" mass="15324" checksum="7824ADB279183DCA" modified="2018-01-31" version="1">MFNAITQSQIYVLDQDEALDFYVGKLGLEVTADVDMGFMRWLTVSVPGHPERQILLEKPGAPAMSEETAQQVRELVTKGAMGGWLIFTTDDCRKTYETLLARGVEFTEEPTDRPYGTDCGLRDPFGNRIRFTQPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC65</accession>
    <name>A0A2G1XC65_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_27530</name>
        <name evidence="12" type="ORF">CYQ11_18115</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48822">
        <property type="protein sequence ID" value="PHQ48822"/>
        <property type="gene ID" value="BLA24_27530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14532">
        <property type="protein sequence ID" value="PPT14532"/>
        <property type="gene ID" value="CYQ11_18115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="115"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="552"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="636" mass="67073" checksum="B67D3ECF76B29DAC" modified="2018-01-31" version="1">MVTSVLVANRGEIACRVFRTCRELGVATVAVYSDADAGTLHVREADAAVRLPGTAPRDTYLRGEAVVAAALAAGADAVHPGYGFLSENAAFARRVRAAGLVWIGPPPEAIEAMASKTRAKALMAAAGVPLLAAVDPAAAGAADMPLILKAAAGGGGRGMRIVREPRLLAAELASARAEAEAAFGDGEVFAEPFLEGARHVEVQLLADTHGTVWELGTRDCSLQRRHQKVIEEAPAPGLAEDVRKTLCRAATDAARAIGYVGAGTVEFLVPADGRRPCFLEMNTRLQVEHPVTERVYGVDLVALQIRLAEGAPLPPGPPPARGHAVEARLYAEDPARDFAPQTGVVRALGFPGEGSTLRVDTGYAAGDTVSPHYDALLAKVVAWAPSRAEAVRKLAHALENARVHGPVTNRDLLVRTLRHPEFTDARTDTGFYARHLPELTVPREGERLAALVAALADASRHPGAWRNVPSQPQSKRYRTEPGGTEHEVRYRCTRQGLVPEGFPGVRVLSAAPDRVVLETGGVRRTHPVAVYGTRVHVGPHALTALPRFPDATARDTDPGSLLAPMPGTVVRLAEGVAVGAVVTAGAPLLWLEAMKMEHRVVAPASGTLTALHAAPGRQVETGELLAVVTETEEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC68</accession>
    <name>A0A2G1XC68_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uma2 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27345</name>
        <name evidence="3" type="ORF">CYQ11_18305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48791">
        <property type="protein sequence ID" value="PHQ48791"/>
        <property type="gene ID" value="BLA24_27345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16647">
        <property type="protein sequence ID" value="PPT16647"/>
        <property type="gene ID" value="CYQ11_18305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="198" mass="22062" checksum="AEE1FF137EC4F194" modified="2018-01-31" version="1">MGGTMTAEPAHAWPVPPPDGYTVADLLTLPDLPPHTELIDGSLVFVSPQRNFHSIVIDLLVEGLRRTVPPGLKVRREMTVVIDQHNAPEPDISVLRAASVRSYDQTYYPVRDVLLAVEVVSPDSVSRDSVTKPFKYALAGIPYFWRVEMAGVEGYPVVHAFELDKETRTYVPTGTYRDALKFTAPFDIDIDLTEIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC97</accession>
    <name>A0A2G1XC97_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27630</name>
        <name evidence="3" type="ORF">CYQ11_18010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48838">
        <property type="protein sequence ID" value="PHQ48838"/>
        <property type="gene ID" value="BLA24_27630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14516">
        <property type="protein sequence ID" value="PPT14516"/>
        <property type="gene ID" value="CYQ11_18010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="280"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="40680" checksum="D0237DFFE04304DA" modified="2018-01-31" version="1">MSVSIDIAGLPAERIVFETSPLAELCLVLHALSEPGHHPRLAGWTTATNAALRPDLADRLREADFLWRNTFSDLFMPYAGLRGGDGRAGTTLAGELDMLDGLDDEQFVATALEFASLAAYDKGAPSPLTDAAARSRALERAAARGPRQLGFAGRLLKDPVAVRGWVRRLLEDCDEAFFAEVWQRVRPALAADTRHKSELLRRRGLREALTAVSPALHLEDGGTRIRADKLAEGEATATDPAVGPGLSFVPSHFGWPHLMILHRPGWRPVVHYPVGSPELPPPASADALKRRLEALAHPLRIQLCRNVARAPYTTGELADLLGVTAPEVSRHLAVLRRADLITTRRRGRYVHYQLDVGTVARLSSDFLEGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCC6</accession>
    <name>A0A2G1XCC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27670</name>
        <name evidence="3" type="ORF">CYQ11_17970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48845">
        <property type="protein sequence ID" value="PHQ48845"/>
        <property type="gene ID" value="BLA24_27670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14509">
        <property type="protein sequence ID" value="PPT14509"/>
        <property type="gene ID" value="CYQ11_17970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="146" mass="16263" checksum="7714E8CD92C95F00" modified="2018-01-31" version="1">MPDLSRTPDDTAAVNALRSGVMRLSRRLKHQRVDESLSPTEMSVLGTLARCGSATPGELARKEHVQPPSMTRIVALLEGKGLVRLEPHPEDRRQKVVTQTEQAEAMLEESRRKRNAWLADLAGRLDEDEWATLRAAAPVLEKLAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCQ6</accession>
    <name>A0A2G1XCQ6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ORF">BLA24_23370</name>
        <name evidence="9" type="ORF">CYQ11_22705</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49037">
        <property type="protein sequence ID" value="PHQ49037"/>
        <property type="gene ID" value="BLA24_23370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15317">
        <property type="protein sequence ID" value="PPT15317"/>
        <property type="gene ID" value="CYQ11_22705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="220"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="302"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="413" mass="43268" checksum="886693399DA1D603" modified="2018-01-31" version="1">MEIVILAVVIAVVALGAISGLVVSSRKKKQLPPAPPSSPSVTAPPAEPHVGEEAETPRAEPRRTVEEVELPEAPAEAETAPVVEPEAAAPAAPAEPEIEVPEPTAGRLVRLRARLSRSQNSLGKGLLTLLSREHLDEDTWEEIEDTLLTADVGVAPTQELVERLRERVKVLGTRTPDELRGLLREELLALIGTDFDRSVHTEPGIGVNGEEKPGVVMVVGVNGTGKTTTTGKLARVLVADGKSVVLGAADTFRAAAADQLQTWGERVGARTVRGPEGGDPASIAFDAVKEGIAEKADVVLVDTAGRLHTKTGLMDELGKVKRVVEKHGSVDEVLLVLDATTGQNGLVQARVFAEVVDITGIVLTKLDGTAKGGIVVAVQRELGVPVKLVGLGEGADDLAPFEPEAFVDALIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD15</accession>
    <name>A0A2G1XD15_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23610</name>
        <name evidence="3" type="ORF">CYQ11_22460</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49075">
        <property type="protein sequence ID" value="PHQ49075"/>
        <property type="gene ID" value="BLA24_23610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15279">
        <property type="protein sequence ID" value="PPT15279"/>
        <property type="gene ID" value="CYQ11_22460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="140" mass="14681" checksum="FF161BB986516783" modified="2018-01-31" version="1">MSPMSQAAQNLNWLITSFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVASGLTSLTAGASRIFEGGTVNQTVVEMERGFLFIMSISDGSSLAVLAHPECDIGLVGYEMALLVDRAGNVLTPDLRAELQGSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD58</accession>
    <name>A0A2G1XD58_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_24130</name>
        <name evidence="4" type="ORF">CYQ11_21945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49158">
        <property type="protein sequence ID" value="PHQ49158"/>
        <property type="gene ID" value="BLA24_24130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15192">
        <property type="protein sequence ID" value="PPT15192"/>
        <property type="gene ID" value="CYQ11_21945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304585" evidence="1">
        <location>
            <begin position="40"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="402" mass="42801" checksum="9716229EFDC20F15" modified="2018-01-31" version="1">MRVHVRRTGRWARAGRTGAVALAVAVMATGVAEARQAGAAGSGGRGSAVLDKDVRAVRAAGGDVAVLAEVSAGREGARARTGPQVPWDAQFRAASTTKTFTAVVVLRLVADGKVSLDDTVEKWLPGVVSGNGNDGSKITVRDLLQQTSGLFDYVNDPDVVRAVTEDFDGHRYDTTPPEQWVAVAMRHQPLFTPDRNHPRWAYSNTNYLLAGMIAEKAAGVPWREQVESRIIAPLGLRHTSVPGANPFLPGPHAQAFLRTPDGGRLDVTEHSLQHTADSGVVSTTADLNTFFRALVTGGLLPKAQLAEMRRTVDRTGATDDLAQWPEGGYGLGLRWTPLSCGGGYWHHEGDGWGSYTRTGVTPDGRRAVAVSVTSQGDRPDPVALNKATRTLVDHALCAPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD59</accession>
    <name>A0A2G1XD59_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7 8">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_24265</name>
        <name evidence="8" type="ORF">CYQ11_21810</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7 8"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49184">
        <property type="protein sequence ID" value="PHQ49184"/>
        <property type="gene ID" value="BLA24_24265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15166">
        <property type="protein sequence ID" value="PPT15166"/>
        <property type="gene ID" value="CYQ11_21810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="13"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="280"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT15166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="403" mass="41142" checksum="1F0229CA24166C40" modified="2018-01-31" version="1">MTGTNGNSGTTSVIVAGARTPMGRLLGSLRSFSASDLGGVAIKAALDRAGIGGDQVQYVIMGQVLTAGAGQIPARQAAVKAGIPMSVPALTVNKVCLSGLDAIALADQLIRAGEFDVVVAGGQESMTNAPHLLPKSREGYKYGAIEMLDAMAYDGLTDPFEGIAMGESTEKHNARLGIRRPEQDEIAALSHQRAAAAQKNGLFEAEITPVEIPQRKGEPVVCSKDEGIRAETTVETLAKLRPAFAKDGTITAGTASQISDGAAAVVVMSKAKAEELGLAWIAEIGAHGNVAGPDNSLQSQPSNAIKHALGKEGITVDDLDLIEINEAFAAVSVQSMKDLGVSPEKVNVNGGAIALGHPIGMSGARLVLHLALELKRRGGGVGAAALCGGGGQGDALILRVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDA2</accession>
    <name>A0A2G1XDA2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_24440</name>
        <name evidence="9" type="ORF">CYQ11_21630</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49217">
        <property type="protein sequence ID" value="PHQ49217"/>
        <property type="gene ID" value="BLA24_24440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15132">
        <property type="protein sequence ID" value="PPT15132"/>
        <property type="gene ID" value="CYQ11_21630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="440" mass="46461" checksum="D627D6BE6FC72B96" modified="2018-01-31" version="1">MGQPVREYLLTLCVTAAVTYLLTGPVRKFAIAAGAMPEIRARDVHREPTPRLGGIAMFGGLCAGLLVAAHLSNLKHVFEVNEPRALLSGAGLIWLLGVLDDKWGVDALVKLGGQMIAAGVMVLQGLTILFIPVPGVGTVSLTPMQGTLLTVALIVITINAVNFVDGLDGLAAGMVCIAAAAFFMYAYRMWFGHGLEAAAPATLFAAVLMGMCLGFLPHNMHPARIFMGDSGSMLIGLVMSAGAISITGQVDPDALALWAGSERAAVHATVPVYIPLLLPLTVIAVPVADLLLAIVRRTWKGQSPFAADRGHLHHRLLEIGHSHSRAVLIMYFWSALIAFGTVAYSVNSASVWILLVIVALSAVGLVLLLMPRFTPRAPRWAERFVPPRYRRKAVPAAPAAEAATAAGERRGEPVPAGLHGATAIGDRSRFAHGRKIGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDM8</accession>
    <name>A0A2G1XDM8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Molybdate ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Molybdenum ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">modB</name>
        <name evidence="17" type="ORF">BLA24_25160</name>
        <name evidence="18" type="ORF">CYQ11_20910</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49343">
        <property type="protein sequence ID" value="PHQ49343"/>
        <property type="gene ID" value="BLA24_25160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15009">
        <property type="protein sequence ID" value="PPT15009"/>
        <property type="gene ID" value="CYQ11_20910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="55"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="288"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="16">
        <location>
            <begin position="580"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="328"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ49343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PPT15009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="645" mass="67208" checksum="0FE93FCDD026DF6D" modified="2018-01-31" version="1">MTGRAVRRGRTPLALGLPAALAVVFLLLPLAGILARTPWGTLPARLTSHEVVEALTLSLTVSGWALLLSLALGVPLAWLLARVEFPGKALVRCLVLLPMVLPPTVAGVALLQGYGRRGLLGTYLDRWFGLTLPFSTTGAVLAATFVAMPFLVISLEGSLAALHPRYEETATSLGAGPSRVFRTVTVPMVAPGLLAGAALCWARALGEFGATITFAGNLPGATQTLPLQVYLLLQDDPEGATAVSLLLLVIATAVLLALRGRWLGAGGHDGPRPPAVPAAGPEPLPAPVRDQPETPGPPLTAHPLRTTVSGATRAALDAPPGTTIAVVGPNGAGKTTLLRALLGLTPRATAAPLYLGGTDVSTAPAHRRHIAWVPQDGALFPHLTALANTAYGLRAQGVPRQEADRRARQWLERLGVGHLAGRRPSRLSGGQAQRVALARALAARPRLLLLDEPLAALDQSTRAHVRHALRTHLAGFPGVCLIVTHDPVEAVSLADHVLVLEDGETVQYATPAELARHPRSPWVARMLGRNAWPVKTTARGTLLLDCGTTLTTADRPADDASTGLAVVGPEAVAVHTARPTGSPRNVWEGTVRELAAQGGRVRVLIDGVPDVIAEITPAAAADLGLSEGAPVWVSVKATEVTFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDN8</accession>
    <name>A0A2G1XDN8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25185</name>
        <name evidence="2" type="ORF">CYQ11_20885</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49348">
        <property type="protein sequence ID" value="PHQ49348"/>
        <property type="gene ID" value="BLA24_25185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15004">
        <property type="protein sequence ID" value="PPT15004"/>
        <property type="gene ID" value="CYQ11_20885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="28111" checksum="1868C543E65F60FC" modified="2018-01-31" version="1">MSYLISPGHRRALAARKAPLRLGVPGFAHPLVAPVEWGGLQRAGLPLDWVVLGGSAPHEPGGPEGGPGCRQDPYWLSAAVPLRTSGVRVLGHLDMGFGSRPFGELLSDAQRFLNWYRVDGFALGRCPADAEALPGVRRVVGALRTLLSGAYVVLGHGTYPCSGYAALADQLVTYAGPWSGYRWSQAAEWTAEHPPERFCHFVHGVPRSHLDEALRIARWQGAGTIYFTDRTDHDGLDPWECLPGFWDEIVSRIGPGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDS2</accession>
    <name>A0A2G1XDS2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_25150</name>
        <name evidence="6" type="ORF">CYQ11_20920</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49341">
        <property type="protein sequence ID" value="PHQ49341"/>
        <property type="gene ID" value="BLA24_25150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15011">
        <property type="protein sequence ID" value="PPT15011"/>
        <property type="gene ID" value="CYQ11_20920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="4">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="133" mass="13996" checksum="E3DF675EF3E7AAE1" modified="2018-01-31" version="1">MRSYTIGQAARLLSVSPDTVRRWADAGRIPTERDEGGKRLIEGPDLAAFSVALAAEATGGDGDESTYTTARNAFPGIITAVKLGDVAAQVEIQAGPHRLVSLLTREAVEELGLAVGMEAVARVKATNVHIDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDY0</accession>
    <name>A0A2G1XDY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_25615</name>
        <name evidence="4" type="ORF">CYQ11_20455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49422">
        <property type="protein sequence ID" value="PHQ49422"/>
        <property type="gene ID" value="BLA24_25615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14928">
        <property type="protein sequence ID" value="PPT14928"/>
        <property type="gene ID" value="CYQ11_20455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758428" evidence="1">
        <location>
            <begin position="23"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="86"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="541" mass="59980" checksum="DB12FB31D8F5426A" modified="2018-01-31" version="1">MRGAKSAVWVAGAITVAMTATACGGGGSSSDDNAAVDPNGTYTYYNTEPQNTLIPSNTNETGGGYIVKNLFRGLVDFDEKGKLRNMAAESVESPDNKVFTVKLKQGWTFHNGEPMTAASFVDAWNWGANAKNAQLNSSWFADIKGYDAVHPEKGDPSADKLEGLKIVNDNEFTIELSHPVSTFKERLFYDAFFPLPKSFYKDPKGFGEHPVGNGPYMQDGDWQHKVEFKTKKFDAYKGEDKPKNGGVIFKFYNKDDAAYNDLVSDKLDVMFQVPTSVMNQYKNDLGDRAVDQMYGGNTNIAFPLYQEEWAKPEKAKVRQGLSLAIDRETIAKTALKGSKDAADGWTPKVVEGYQPNSCGEFCKFDPAKAKELIKAGGGVPGNKITITYNVDGGHKEWVDAVCNDIRQNTGVECVGDPKPTFQQVRADITEKKMTSAFRMAWVQDFPNISNFIAEQYRTGAGANDMAFSDKGLDDLMKQADEAKTVEDSNKIYHQVEAKLAEQMPSIPLFFDHTKAGYSKKVKNVKFDTFRQAIWTEVEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDY9</accession>
    <name>A0A2G1XDY9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25760</name>
        <name evidence="2" type="ORF">CYQ11_20310</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49450">
        <property type="protein sequence ID" value="PHQ49450"/>
        <property type="gene ID" value="BLA24_25760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14900">
        <property type="protein sequence ID" value="PPT14900"/>
        <property type="gene ID" value="CYQ11_20310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="15314" checksum="200B8AE4C44D6780" modified="2018-01-31" version="1">MRANLLLMHYARSPLDCPACEADRLTSMADARIAICVASGVAIEDIDPATGYNHSRAAYDRARASWIDVIRQHGASEFHEVRDIAWARGLWAEKRPEFVEGDDWLTEALDAHKEFIASLGHPCRRTSCLVHFPAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE03</accession>
    <name>A0A2G1XE03_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_25610</name>
        <name evidence="8" type="ORF">CYQ11_20460</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49421">
        <property type="protein sequence ID" value="PHQ49421"/>
        <property type="gene ID" value="BLA24_25610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14929">
        <property type="protein sequence ID" value="PPT14929"/>
        <property type="gene ID" value="CYQ11_20460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="308" mass="33566" checksum="11614F2BF078DFAB" modified="2018-01-31" version="1">MGRFVARRLLQMIPVFIGTTLLIFLMVYSLPGDPVKALFGSKAADPATVERLRHEFGLDKPLLEQYWNYLTGLFQGDFGKSFTGRPVADLMADAFPVTIRLALLAFGIELVLGISLGMLTGLKRGKLVDQLVLVLTLIVVSIPVFVIGFLTQFALGMKWKLITPTVQDSMDVGQLMVPAAVLAALSLAYVTRLTRTTVVENLRADFMRTAVAKGLPRRRVIGVHLMRNSLIPVVTFLGTDLGMLMGGAIVTEGIFNVQGVGNTLYRAIQTSEGPTVVGIVTVLVLVYLVSSLVVDLLYAVLDPRIRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE17</accession>
    <name>A0A2G1XE17_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25915</name>
        <name evidence="3" type="ORF">CYQ11_20155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49477">
        <property type="protein sequence ID" value="PHQ49477"/>
        <property type="gene ID" value="BLA24_25915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14873">
        <property type="protein sequence ID" value="PPT14873"/>
        <property type="gene ID" value="CYQ11_20155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="101" mass="10939" checksum="C721B2578FB9C6A4" modified="2018-01-31" version="1">MAGRGPSPALVLLLVQRLPDTSLTVALASGGREHFGWGQDRHLAADLFDAINSNTRATGQWGKGKAPKIPPFPRPQAKAKAKKASKRPATVAQLYQHFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE40</accession>
    <name>A0A2G1XE40_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26020</name>
        <name evidence="3" type="ORF">CYQ11_20045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49496">
        <property type="protein sequence ID" value="PHQ49496"/>
        <property type="gene ID" value="BLA24_26020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14853">
        <property type="protein sequence ID" value="PPT14853"/>
        <property type="gene ID" value="CYQ11_20045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="397" mass="43821" checksum="64401B61B18FE07A" modified="2018-01-31" version="1">MTTSLLTDLLATPTPPPIPARQTDPDRDYTRQIEVSGNAAEVTVRGPVEMDPDTSAADVLRAHQLDPADWDVKAFRSSEWTLPNGELGVSARFTFARRQDPEAERPNLDELLALVDRYDPPRLSTAQRQGDHTLIVALGDMQFGKADGDGVAGTLQRTIACIDKAAALLPEYRKRFAIGHVHLAWLGDHIEGYQSQGGANAWRTSLTLTEQIRLTRRVMAHAVLRLAPLVERLTVAAVPGNHGEAVRFNGKGVTRYDDSHDTDALIAVQEAVSLAPKEFGHVEFFVPDTDELTVVVECSGSVIAHAHGHQWRSGKHFEWWKGQSFNKASAMHQADVLLAGHLHHEFVDTDGPRTFIQVPAMESESTWWRHRTGTRGAPGLMVMITKDGEVPVKEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE46</accession>
    <name>A0A2G1XE46_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">BLA24_26105</name>
        <name evidence="7" type="ORF">CYQ11_19535</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49510">
        <property type="protein sequence ID" value="PHQ49510"/>
        <property type="gene ID" value="BLA24_26105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14770">
        <property type="protein sequence ID" value="PPT14770"/>
        <property type="gene ID" value="CYQ11_19535"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="332" mass="35745" checksum="BB9993812BF64BF8" modified="2018-01-31" version="1">MDRMTATPARKVLLAAPRGYCAGVDRAVIAVEKALEQYGAPVYVRHEIVHNKYVVKTLEKKGAIFVDETAEVPEGNIVIFSAHGVAPVVHEEAERGKLATIDATCPLVTKVHKEAVRFANDDYDILLIGHEGHEEVIGTSGEAPDHITLVDGPEDVANVEVRDPEKVVWLSQTTLSVDETMETVGALKQRFPLLQSPPSDDICYATQNRQVAVKQMGAEADLVIVVGSRNSSNSKRLVEVALGAGARASYLVDYAEEIDETWLEGVSTVGVTSGASVPEILVEGVLEWLAQRGFGDVETVTAAEEHIAFSLPKELRRDLRAEAAALTGDSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEJ2</accession>
    <name>A0A2G1XEJ2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_27020</name>
        <name evidence="6" type="ORF">CYQ11_18610</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49664">
        <property type="protein sequence ID" value="PHQ49664"/>
        <property type="gene ID" value="BLA24_27020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14612">
        <property type="protein sequence ID" value="PPT14612"/>
        <property type="gene ID" value="CYQ11_18610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ49664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="270" mass="28600" checksum="3E8CD341A61AEAD3" modified="2018-01-31" version="1">MTNQNTSAFTLDPVAGTSLVTAAQRARESARDDALFHDPLAAALAGPAGTARLDAFGDVPAIPVRTRFFDDAIGGAVGDGGPRQLVIVAAGMDTRAYRLRLPADVTLYELDRPELLAHKERLLGGVAPTCHRTAVGADLAAAGWEEALADAGFRADLPTCWLVEGLTQYLEEPDVHTLLDRISALSAPGSRLLADFVAGAMLAAPETRPVLDLMATWGSPWRYGTDDPTTLLAERGWRAEVRTFAGVGEALGRPMPGGDEMSGWLVEGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEJ9</accession>
    <name>A0A2G1XEJ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26935</name>
        <name evidence="2" type="ORF">CYQ11_18700</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49653">
        <property type="protein sequence ID" value="PHQ49653"/>
        <property type="gene ID" value="BLA24_26935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14625">
        <property type="protein sequence ID" value="PPT14625"/>
        <property type="gene ID" value="CYQ11_18700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="17934" checksum="20D87F6F1E73AB59" modified="2018-01-31" version="1">MGFWGYLLVGRGGARALVECPALAANRDHLVPAGAFGDGWQLWEHPEHPALGDGIDTLVRALADQTGAPALAAYVMESDCAVLVGAGPGDPSWSACLGRTTLARYMAETGLGLDELFPGPEAAAAHCAAWADAAGCAADAAELVRVLAADPEPSVETLFRELLAGLGVMEPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF07</accession>
    <name>A0A2G1XF07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_19260</name>
        <name evidence="12" type="ORF">CYQ11_11540</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49791">
        <property type="protein sequence ID" value="PHQ49791"/>
        <property type="gene ID" value="BLA24_19260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13433">
        <property type="protein sequence ID" value="PPT13433"/>
        <property type="gene ID" value="CYQ11_11540"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ49791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="377" mass="40551" checksum="2AC01D7286563E44" modified="2018-01-31" version="1">MAAPARREAFRAVALHLGLALIGFGVLLVINRHLGHGGQWLLHRWDSGNYLRVAERGYPRSLPYRDDGTPAYNRLAFFPLVPALIRGVHLVTGLPFAYAGVLVSWCAAAVAAAGVYTLVRAAGGRPAAGYACVALWSCSPYAFALWVPYSEAVFTAVLVWAMVALLADRWLVAGALCVVAGTVRPTATVLIATVMVTAGWAVLRRGGGWRPWAALFLAPVGLLAGWLYLGSRVGRWDGWFEAERAWGQSFDFGLGTVRFLRLVLFYRDGEVHDVRHAAVVALVLLTAVGVLALALDRSVPWPLVVLVAGAWLLMMGTPGSQFSKPRFMLPFLPVLLLLVARPLARAPLVVRICLYGGGAVVSGWYAAGLLVLFDGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF43</accession>
    <name>A0A2G1XF43_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lon proteolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19595</name>
        <name evidence="4" type="ORF">CYQ11_11200</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49847">
        <property type="protein sequence ID" value="PHQ49847"/>
        <property type="gene ID" value="BLA24_19595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13377">
        <property type="protein sequence ID" value="PPT13377"/>
        <property type="gene ID" value="CYQ11_11200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758841" description="Lon proteolytic domain-containing protein" evidence="1">
        <location>
            <begin position="45"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="164"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="28029" checksum="0BD8F26DB9354363" modified="2018-01-31" version="1">MPAETPSAPAAAKNKRTRTLALCAVPVVALLAVAASVPLPFVIAQPGSTTANVLGEHKNKPVITITGAETRRTTGQLRMTTIEATGPGTDVSLGDVADSWFRTDRAVMPRGSVYPAGQSDEQIERHNVAEMEKSQDAASQAALRYLHRSPGDVKVDLSLADVGGPSAGLLFALGIIDKLDGDGRGGDLTGGRSIAGTGTIEPDGTVGAVGGVSLKTQAAGRDGATVFLVPKGECSDAQAELPKGMRLIPVTDLKDAVSSLRNLAAGQRVPTCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFF6</accession>
    <name>A0A2G1XFF6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">kdpB</name>
        <name evidence="15" type="ORF">BLA24_20165</name>
        <name evidence="16" type="ORF">CYQ11_10625</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49941">
        <property type="protein sequence ID" value="PHQ49941"/>
        <property type="gene ID" value="BLA24_20165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13282">
        <property type="protein sequence ID" value="PPT13282"/>
        <property type="gene ID" value="CYQ11_10625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="401"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ49941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT13282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="716" mass="75125" checksum="5DCA5C7CCD54CB11" modified="2018-01-31" version="1">MLHLAPEQHPEQAVRPRPSAPGGGRRRHRRVGGGVVEPRQLIASFPDAVRKLHPRVMVKHPVLFVVETGSVLTTLSAILAPSVFAWLISVWLWLTVVFANLAEAVAEGRGKAQADTLRRTRAGTVARRLRTWRVGLDHRAWVEERVPAGDLRPHDVVVVEAGETVPGDGEVVEGIAAVDESAVTGESAPVLRESGGDRSSVTGGTRVLSDRIVVRITSRPGNSFLDRMISLVEGTSRQKTPNELALNILLAALTVVFLLAVVSLQPMASWAGAPQSITVLVALLVTLIPTTIGALLSAIGIAGMDRLVQRNVIALSGRAVEAAGDVDTLLLDKTGTITLGDRQAASFVPVQGVTPELLADAAQLSSLADDTPEGRSVVELARRYGVQHHPGEFAHGRFVPFSAETRMSGVDFAFEGEFCRIRKGAGSAVAQWVTRRGGPVPAEAGWICDTIAASGGTPLLVAVEDPDGARVLGAVHLKDVVKPGIAERFAALRAMGIKTVMVTGDNPLTAKAVAAEAGVDDYLAEATPEAKLARIKEEQAGGKLVAMTGDGTNDAPALAQADVGVAMNTGTAAAKEAGNMVDLDSSPTKLVEIVEVGKQLLITRGALTTFSICNDVAKYFAIVPAMFGGVAGYEGLEKLNVMGLHSPTSAIASAIVFNALVIVALIPLALRGVRYVPSSAHALLRRNLSVYGLGGLVAPFAGIKAIDLLMQFVPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFG2</accession>
    <name>A0A2G1XFG2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA carboxylase subunit beta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20360</name>
        <name evidence="4" type="ORF">CYQ11_10425</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49973">
        <property type="protein sequence ID" value="PHQ49973"/>
        <property type="gene ID" value="BLA24_20360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13250">
        <property type="protein sequence ID" value="PPT13250"/>
        <property type="gene ID" value="CYQ11_10425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="280"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="533" mass="57132" checksum="9BC83ECAEF0F0DBA" modified="2018-01-31" version="1">MTTTEDPALAPLTGPPPADSRARAALLALAKQTAKDGPGPHATEAQWAKGKLTVHERLALLFDEGSFQETEPLRRHRATGFGLEDRRPYTDGVVTGWGTVHGRTVFAYAHDFRIFGGSLGEAHAQKIHKLMDLAREAGAPLVSLSDGAGARIQEGVTALAGYGGIFRRNVAASGVIPQISVMLGPCAGGATYSPALTDFVFMVRGTAQMYITGPDVVHAVTGERITHDRLGGADVHAAVSGAAHFAHEDEGECLSEVRYLLSLLPQNNRELPPSVPSEDPADRRCEALFDLVPADPGRSYDMRLVIEEIVDDGDCVEVHASWATNIVCALARLGGHVVGLVANQPASLAGVLDIHASEKAARFVQMCDAFSIPLVTLVDVPGFLPGKDQEHGGIIRHGAKLLYAYCNATVPRISLVLRKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVVFRREIAQAADPEAVRADRIKQYREELMHPYYAAERGLVDDVIDPAETRAVLIRSLAMLRAKRADMPARKHGNQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFL5</accession>
    <name>A0A2G1XFL5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_20705</name>
        <name evidence="4" type="ORF">CYQ11_10075</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50034">
        <property type="protein sequence ID" value="PHQ50034"/>
        <property type="gene ID" value="BLA24_20705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13188">
        <property type="protein sequence ID" value="PPT13188"/>
        <property type="gene ID" value="CYQ11_10075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="379" mass="40019" checksum="D5A28A7466BE13F1" modified="2018-01-31" version="1">MTGGAETPTARMRKALHRARTSVRKAGVDYFRGDGSDSVALTALLLSVPALAWGTVVQPEWCAPAALVLPIVAGGLLLRPASLLGLYAAAAAALILESAVLDDPSASGAGRVSPGTILVVAAVGFLGLLIAQFRSRVGVPWRRGGTMLFDLRERIRVQSKLPKLPHGWHREMALRPAGGQSFSGDFVVAARTNGGRTLEVVLTDVSGKGMDAASRALLLSGAFGGLLGSLPPHDFLPAANGYLLRQDWDEGFATSVHLVLDLDTGDYELLSAGHVPGLHLTAGTGRWEEKAGEGPLLGVYDGAQFDSVKGTLRPGDVLMLFTDGLVETSERELTEGMDRLTGEADRYVTSGFHGAAWHLIEAVAKDVNDDRALLLICRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFT3</accession>
    <name>A0A2G1XFT3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21145</name>
        <name evidence="2" type="ORF">CYQ11_09640</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50100">
        <property type="protein sequence ID" value="PHQ50100"/>
        <property type="gene ID" value="BLA24_21145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13120">
        <property type="protein sequence ID" value="PPT13120"/>
        <property type="gene ID" value="CYQ11_09640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="136" mass="14191" checksum="E8CAF4D272784CB6" modified="2018-01-31" version="1">MVPSRGIERGGNAVSEAGSGKVLDIKAEDLKSSAPTFSEQSGKLREALTTLTTTLDGLGAPWGEDEQGKQFAKGYTPARKKIENATKILIGGLASIHEAMADMSDGHVDNDKLIGSMFSKKGVKDGGRQDAGKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFT8</accession>
    <name>A0A2G1XFT8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mreD</name>
        <name evidence="9" type="ORF">BLA24_20885</name>
        <name evidence="10" type="ORF">CYQ11_09895</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50061">
        <property type="protein sequence ID" value="PHQ50061"/>
        <property type="gene ID" value="BLA24_20885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13159">
        <property type="protein sequence ID" value="PPT13159"/>
        <property type="gene ID" value="CYQ11_09895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="237" mass="24519" checksum="CA7E0456250559EB" modified="2018-01-31" version="1">MRLNRILLSAALVVLALVVQVSIFARLHLPGAVPDLVLLVVVALALVHGHTAGALVGFGAGLLADLAPPADHATGRYALVLCLIGYLVGLVRPETGRLRSATVPMLAVLAAAIGSTLLYALVGSLVGDTAARHVGLTGLVCTAALYDLLLAPFTVPLIMALARRTAGDPLTAEGTAVATAEGPYSRMSGGSFRVGRASRTGRKNLMGRRSWIGGQRGGLLVRSAKKQRIKIKGGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFT9</accession>
    <name>A0A2G1XFT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_21180</name>
        <name evidence="3" type="ORF">CYQ11_09605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50104">
        <property type="protein sequence ID" value="PHQ50104"/>
        <property type="gene ID" value="BLA24_21180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13115">
        <property type="protein sequence ID" value="PPT13115"/>
        <property type="gene ID" value="CYQ11_09605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="31568" checksum="B0DE3FA9CDD71DF3" modified="2018-01-31" version="1">MPPSTPLPTIRRRRLGAELRRLRERADMSATEAGALLGATQSRISNIEAGRYGVSADRVRALARIYDCSDQALIEALAGMTGERKRGWWEEYRELLPASLLDLAEVEHHATAIRVSQVINIPGLLQTTDYARAIFREAVPELVPHEVEHRISHRIKRQAVLYRKTQPAYTAIIHEAALRMQFGGTAVTKSQLKHLLAMSERENITVVVIPFDGTSFPSAGHGIDCFRGTVPQLDTVLLDTAHNGTFIDASAQLDRCRLVLDRMESVALKPDLSRDLIHGIAQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFU7</accession>
    <name>A0A2G1XFU7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="11" type="ORF">BLA24_21120</name>
        <name evidence="12" type="ORF">CYQ11_09665</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50097">
        <property type="protein sequence ID" value="PHQ50097"/>
        <property type="gene ID" value="BLA24_21120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13123">
        <property type="protein sequence ID" value="PPT13123"/>
        <property type="gene ID" value="CYQ11_09665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="378" mass="40501" checksum="6156D7E29D9FE07B" modified="2018-01-31" version="1">MATDYYAVLGVRRDASQDEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKKQVYDLGGDPLSASGGAGAGAGFGAGFGNFSDIMDAFFGQTSQRGPRSRTRRGQDAMIRLEVSLNEAAFGTTKDIQVDTAVVCTTCSGEGAAPGTSAQTCDMCRGRGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRVRSRRTLTVKIPAGVDNGTRIQLAGEGEVGPGGGPPGDLYVEIHESKHPVFQRRGDDLHCTVTIPMTAAALGTKVPLETLDGVEEIDIRPGTQSGQSIPLHQRGVTHLRGGGRGDLVVHVEVTTPAKLDPQQEDLLRQLAKLRGEERPMGEFKPGQQGLFSRLKDAFNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFZ5</accession>
    <name>A0A2G1XFZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_21280</name>
        <name evidence="8" type="ORF">CYQ11_09505</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50121">
        <property type="protein sequence ID" value="PHQ50121"/>
        <property type="gene ID" value="BLA24_21280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13098">
        <property type="protein sequence ID" value="PPT13098"/>
        <property type="gene ID" value="CYQ11_09505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ50121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="479" mass="48290" checksum="63D7BA68E8C4D532" modified="2018-01-31" version="1">MAIETPPLTSAPPASPGMATRDKLVLLLLCAAQFIVALDFSILNVALPVLGDDLGMGQADLQWAVTAFALPSGGFLLFFGRTADLYGRRKLFLAGLALFTAASVLATLAWDPASFLAGRALQGLGAAVIVPTGMSLLTTTFAEGPQRERALGISGTLMSLGFTIGMVLGGVLTDALGWRSTMGLLAVAGVGVLLAAPGLLTESRLATRPRLDVPGAVTVTGGLLAVIYALSTAAQHGFGGVDVLVTLIAGVLLLVAFVVVEARAAEPLVSLPMLRRRTVAWGNLAGLVTFAMMSTVIFLLTLYLQEVLELSAFRTGLVFGVQGLLAAASGMVAPRVIARFGARTTLVAGLLVQAGFTASLLGLGVSSGAWLALAGVSLGCVGHLWAIVAYGVTATSGLPDAEQGLATGLVTSSQQIGITIGIPLLSAVSSARVAALGDGGEGFASATLGGIKLALGLDAAVVAAVAVLVAAGLRRVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG55</accession>
    <name>A0A2G1XG55_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyxylulose-5-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_21850</name>
        <name evidence="2" type="ORF">CYQ11_08935</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50216">
        <property type="protein sequence ID" value="PHQ50216"/>
        <property type="gene ID" value="BLA24_21850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13000">
        <property type="protein sequence ID" value="PPT13000"/>
        <property type="gene ID" value="CYQ11_08935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="112" mass="12593" checksum="600FAD1B0D051797" modified="2018-01-31" version="1">MPPAKTAYVCLPCRASYKQRHPSPGDDVRVCPRCAGPLIHVGSAFAPPRRRDTAAWRTLSVLLHAGIRFRKDCCFGGPGYRPRTLSEVRERMTYARRSGEPFAQALLRREVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGQ0</accession>
    <name>A0A2G1XGQ0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_21945</name>
        <name evidence="5" type="ORF">CYQ11_08840</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50418">
        <property type="protein sequence ID" value="PHQ50418"/>
        <property type="gene ID" value="BLA24_21945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16438">
        <property type="protein sequence ID" value="PPT16438"/>
        <property type="gene ID" value="CYQ11_08840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304639" evidence="3">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="212" mass="21213" checksum="0BCA372CD99B3524" modified="2018-01-31" version="1">MLLAPLLAALTAVLGAAPAHADGYRYWSFWQGAGQEWTYATQGPATLRPGDGQAVGFRFAVSEDSAHAAKPRAAAGFGAVCAGTPAKEGRKRVAVVLDFGTPADAPSGDAPPAARTACAQVAADASAGEVLAAVAEPLRYDSSALLCAIAGYPRTGCGERVGERKSTAAAEEGTASGKKDDGGPSAGLVGGVAVVVALGAAGLWQARRRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT9</accession>
    <name>A0A2G1XGT9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_16495</name>
        <name evidence="6" type="ORF">CYQ11_16790</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50447">
        <property type="protein sequence ID" value="PHQ50447"/>
        <property type="gene ID" value="BLA24_16495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14301">
        <property type="protein sequence ID" value="PPT14301"/>
        <property type="gene ID" value="CYQ11_16790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="226" mass="24176" checksum="B9897C122B5D1F14" modified="2018-01-31" version="1">MAIRVMLVDDQVLLRTGFRMVLAAQPDMEVVAEAGDGAEALEVLAGTAVDVVLMDVRMPRLDGVEATRRICAQDDPPKVLILTTFDLDEYAFSALKVGASGFMLKDVPPAELLGAIRSVHSGDAVVAPSTTRRLLDRFTPMLPSAGNEPTSAELGRLTEREREVMLLVAQGLSNGEIAARLVLSEATVKTHVGRILTKLGLRDRVQVVVMAYESGLVRAGGGGPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGY9</accession>
    <name>A0A2G1XGY9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4177 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_16910</name>
        <name evidence="2" type="ORF">CYQ11_16370</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003967454.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50508">
        <property type="protein sequence ID" value="PHQ50508"/>
        <property type="gene ID" value="BLA24_16910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14236">
        <property type="protein sequence ID" value="PPT14236"/>
        <property type="gene ID" value="CYQ11_16370"/>
    </dbReference>
    <dbReference type="GeneID" id="63980884"/>
    <dbReference type="GeneID" id="66961046"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="52" mass="5964" checksum="C15DE60F0EE24CD1" modified="2018-01-31" version="1">MTKWEYATVPLLVHATKQILDTWGEDGWELVQVVPGPNNPEQLVAYLKREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH20</accession>
    <name>A0A2G1XH20_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17020</name>
        <name evidence="3" type="ORF">CYQ11_16260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50527">
        <property type="protein sequence ID" value="PHQ50527"/>
        <property type="gene ID" value="BLA24_17020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14219">
        <property type="protein sequence ID" value="PPT14219"/>
        <property type="gene ID" value="CYQ11_16260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="27412" checksum="C407C316E6958668" modified="2018-01-31" version="1">MRSATVTPEGDRIRWAELPGREPTRVYVHGLGSTSPAYFAEAAAHPLLAGHRSLLIDLLGHGISDRPGTFDYTLEAHADALAEALTSANVAGAELIAHSMGGSVAIVLAARHPHLVSRLVLIDANLDPMQPTPGSGGSRGIAAYSEEEFLAGGWREVRDRAGAHWWSTMRLAGREALHRSAVHLVRGSVPTMRELLLDLTIPRTYLVPEADGPVVGGDALAEAGVAVVPVPDCGHNIMLDNPEAFARATAEALGGPDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH50</accession>
    <name>A0A2G1XH50_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_17220</name>
        <name evidence="4" type="ORF">CYQ11_16055</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50557">
        <property type="protein sequence ID" value="PHQ50557"/>
        <property type="gene ID" value="BLA24_17220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14189">
        <property type="protein sequence ID" value="PPT14189"/>
        <property type="gene ID" value="CYQ11_16055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305531" evidence="2">
        <location>
            <begin position="42"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="682" mass="73134" checksum="C6A121CD002BF279" modified="2018-01-31" version="1">MYPRARRPHRPRRPSRLRPLGVVTLLLGLLGAALAAGPARATDDASRPRPRLVQPVDPQRWRNPDDMTWAEYRPVPGTDWANPDVKPTRRTFKGALVLLDYPDEEFSVSKPPGSTIFGNPLPSASGVPRARLPRFYEDFLNKPGTLNHGHTINEYWMEDSGGRMGVDLTAFGVYRMPGKSYQYGIEPGMNPGACPQGDTCGKDIRTDGKSAWVADVGAGRAGEFDFVFYLTAGVDESSAWQEFGPMKFASPRDVPAAWGPPSPVPGGGTTAATRYVPWTSWQAAARIWPNAANGSSTQTESSGMATFAHELSHILGIGDNYNNPYGTPLSRSYTGIWGMLSRGSFNGPGGPHTRWQIPATAGGSMGAQHVLRDKIKLGIVDEKNVLRLDRDALKNSGLVVARVTARSAPPGEKGLAGVNVTMKRDLSPACDRTTDPLCDGGGYDNYTVEVVDRMGMDSFTPDSGVLLAKTKNADRAPFAWVVDAHPEDIGLVDFTRPDGTPQKITMGDYRQLSDALFHAGADSGSSYEYVDEANRLHFYVLDVRRDATGVLSYSVGVRSLDGPGPQPRGLALGRAKAKGKPAGGRALCTFPLTNTGGTTPGTDPYLSSDVYRLTATTTGRGWSAWLPTHLTSTPAGTTVPVDVAVTAKANADRTGTITLTARSESDPGKTVRGNCTVRRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH94</accession>
    <name>A0A2G1XH94_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper chaperone PCu(A)C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17530</name>
        <name evidence="3" type="ORF">CYQ11_15745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50603">
        <property type="protein sequence ID" value="PHQ50603"/>
        <property type="gene ID" value="BLA24_17530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14142">
        <property type="protein sequence ID" value="PPT14142"/>
        <property type="gene ID" value="CYQ11_15745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304944" evidence="1">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="159" mass="16356" checksum="FDA524234BFED61C" modified="2018-01-31" version="1">MGKATVITAAALPLAVAGALLLVTGCDSGSGTSDKAELSVSGAYLPQPAMADMAAAYFTVKNDGGKADQLTGVTSPLSPDVTMHTTEGSQMKHAQKLEVPAKGELSLARGGSHLMLGKLDHLPKTGEKVEFTLHFATSAPIKIQVPVESASYRPPSPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHA1</accession>
    <name>A0A2G1XHA1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_17580</name>
        <name evidence="6" type="ORF">CYQ11_15695</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50610">
        <property type="protein sequence ID" value="PHQ50610"/>
        <property type="gene ID" value="BLA24_17580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14135">
        <property type="protein sequence ID" value="PPT14135"/>
        <property type="gene ID" value="CYQ11_15695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ50610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT14135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="303" mass="33241" checksum="6536A596F4A7F0E9" modified="2018-01-31" version="1">MSTLHIDSVSRWFGNVVAVNDVTMSVGPGVTGLLGPNGAGKSTLINMMGGFLAPSTGTVTLDGETIWRNEQIYRHIGIVPEREAMYDFLTGEEFVLANAELHGLGAKEARRALATVEMEYAQDRKIATYSKGMRQRVKMASALVHEPSVLLLDEPFNGMDPRQRMQLMDLLRTMGAEGRTVLFSSHILEEVEQLAAHIEVVVAGRHAASGDFRKIRRLMTDRPHRYLVRSSDDRALAAALIADPSTSGIEVDLGEQALRVQAVDFGRFTELLPRVAHAHGIRLLTVSPSDESLESVFSYLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHN9</accession>
    <name>A0A2G1XHN9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_18440</name>
        <name evidence="2" type="ORF">CYQ11_14840</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50758">
        <property type="protein sequence ID" value="PHQ50758"/>
        <property type="gene ID" value="BLA24_18440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13984">
        <property type="protein sequence ID" value="PPT13984"/>
        <property type="gene ID" value="CYQ11_14840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016874">
        <property type="entry name" value="TcmP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028177">
        <property type="entry name" value="Polyketide_synth_Omtfrase_TcmP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="30519" checksum="762A632E98A9EEA1" modified="2018-01-31" version="1">MGREKVTLHGAPETMLATLYGRALDSRAPCPVLGDEEAARAVARIDYDFRRTGITRINAAGIALRAKLLDDWTAEFLADHPTATVLHLACGLDTRPHRLAPPPTVRWVDVDYPEVVALRDRLLPRPPGDYRVIGASVTDGRWLGEVPADRPTVTVFEGLSMYLRKEDGKRLVQGVTGRFPSGQLLFDCFSGLGIRLQKLVTPVRRAGATLHWAVDDPDELEGWHEGLRCVDVLRSVDMPEVDKLPPAGKLGLWVMTRTPGWRNVARIVRYEFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHX5</accession>
    <name>A0A2G1XHX5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_18915</name>
        <name evidence="3" type="ORF">CYQ11_14365</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003949541.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XHX5"/>
    <dbReference type="EnsemblBacteria" id="PHQ50833">
        <property type="protein sequence ID" value="PHQ50833"/>
        <property type="gene ID" value="BLA24_18915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13909">
        <property type="protein sequence ID" value="PPT13909"/>
        <property type="gene ID" value="CYQ11_14365"/>
    </dbReference>
    <dbReference type="GeneID" id="58435848"/>
    <dbReference type="GeneID" id="63981485"/>
    <dbReference type="GeneID" id="67397645"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="68" mass="7546" checksum="CB0F7693722720C8" modified="2018-01-31" version="1">MTARTPDAEPLLTPAEVATMFRVDPKTVTRWAKAGKLTSIRTLGGHRRYREAEVRALLAGIPQQRSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI02</accession>
    <name>A0A2G1XI02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19075</name>
        <name evidence="3" type="ORF">CYQ11_14205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50855">
        <property type="protein sequence ID" value="PHQ50855"/>
        <property type="gene ID" value="BLA24_19075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13886">
        <property type="protein sequence ID" value="PPT13886"/>
        <property type="gene ID" value="CYQ11_14205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="182" mass="20283" checksum="6DEC3FA579AC23AC" modified="2018-01-31" version="1">MADTPGPAEPSLDEQIAAYQREFQDLDPQVERVVSALSRLNRRMNVAYGRQTAELGISNAEWEVLKALVLAGEPYSLGPGDLAKRLGLTPAAMTHRIDRMVGEGLVTRERDESNRVRVIVGITEEGRAKWLDGLRMATVFEEELLQDLSNDERGRLGEMLTRLLRRVEEAQPDAGGRLSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIC6</accession>
    <name>A0A2G1XIC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EamA family transporter RarD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Protein RarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rarD</name>
        <name evidence="11" type="ORF">BLA24_14430</name>
        <name evidence="12" type="ORF">CYQ11_13645</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50986">
        <property type="protein sequence ID" value="PHQ50986"/>
        <property type="gene ID" value="BLA24_14430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13792">
        <property type="protein sequence ID" value="PPT13792"/>
        <property type="gene ID" value="CYQ11_13645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ50986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT13792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="37452" checksum="85AF4C67E5BC3A69" modified="2018-01-31" version="1">MTTSSARSTVARSSSKPCAPREGTVSPEPARSETRTGLLCGVAAYGIWGLFPLYWPLLEPTDAGEILAHRMVWSLVTVVAVLAVTRRWAWIRPLLREPRRLALAALGATLIAANWWVYIWAVNAGHVVETSLGYFINPLATITLGVVVLRERLRPAQWAAVGVGAAAVVVLAVGYGKPPWIALAIAATFSTYSLVKKKVALGGLESMAVETAVQFLPALAALLFLGARGGSTFASEGTGHALLLLGTGVITAVPLVSFGAAAVRLPLSVLGMLQYLAPVFQFALGLLVFHEAMPAERWAGFALVWLALAVLTWDALRTARHAQAALRRAEAKAATGNTENTIATQASEVTAQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG6</accession>
    <name>A0A2G1XIG6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">BLA24_14830</name>
        <name evidence="6" type="ORF">CYQ11_13240</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956442.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51052">
        <property type="protein sequence ID" value="PHQ51052"/>
        <property type="gene ID" value="BLA24_14830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13725">
        <property type="protein sequence ID" value="PPT13725"/>
        <property type="gene ID" value="CYQ11_13240"/>
    </dbReference>
    <dbReference type="GeneID" id="58435566"/>
    <dbReference type="GeneID" id="63982147"/>
    <dbReference type="GeneID" id="66955263"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="73" mass="8425" checksum="C162942E0F126612" modified="2018-01-31" version="1">MAKKQGAIEIEGTVIESLPNAMFKVELQNGHKVLAHISGKMRMHYIRILPDDRVVVELSPYDLTRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIG9</accession>
    <name>A0A2G1XIG9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">BLA24_14685</name>
        <name evidence="11" type="ORF">CYQ11_13385</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004950419.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51026">
        <property type="protein sequence ID" value="PHQ51026"/>
        <property type="gene ID" value="BLA24_14685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13751">
        <property type="protein sequence ID" value="PPT13751"/>
        <property type="gene ID" value="CYQ11_13385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ51026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="156" mass="17445" checksum="09B0B88F1510DBF0" modified="2018-01-31" version="1">MPRKGPAPKRPVIIDPVYGSPLVTSLINKILLHGKRSTAERIVYGAMEGLREKTGNDPVITLKRALENVKPALEVKSRRVGGATYQVPVEVRPGRASTLALRWLVGYSRARREKTMTERLMNELLDASNGLGASVKKREDTHKMAESNKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIU2</accession>
    <name>A0A2G1XIU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15390</name>
        <name evidence="3" type="ORF">CYQ11_12685</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51147">
        <property type="protein sequence ID" value="PHQ51147"/>
        <property type="gene ID" value="BLA24_15390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13630">
        <property type="protein sequence ID" value="PPT13630"/>
        <property type="gene ID" value="CYQ11_12685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="168"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="30985" checksum="6DD9045B4B1175C1" modified="2018-01-31" version="1">MVARPDITAWRPAVAGVAEVFHAHFTDHAYPMHAHDTWTLLIVDDGMVRYDLDRHEHGALSDLVTLLPPHVPHNGASVTPHGFRKRVLYLEAELLGEEFIGRAVDNPELDDPLLRRRIHQLHTVLAERGEDLEAESRLAMICERLLRHLGHRQVAPVPARPEQSRLAHRLRDLLDERVLEGLTLQDAADLLHAHPAHLVRAFSREFGIAPHQYLTACRVDRARRLLLDGQPSQMVAASTGFCDQSHLTRTFKRLVGVTPGRYADTARRFPVDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIY2</accession>
    <name>A0A2G1XIY2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_15610</name>
        <name evidence="3" type="ORF">CYQ11_12465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51183">
        <property type="protein sequence ID" value="PHQ51183"/>
        <property type="gene ID" value="BLA24_15610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13594">
        <property type="protein sequence ID" value="PPT13594"/>
        <property type="gene ID" value="CYQ11_12465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="212" mass="24255" checksum="CC2FDDB8F128FDFF" modified="2018-01-31" version="1">MNTWPVELTDGDVVLRPIRLRDQRAWREVNRRNRDWLRPWEATIPPPPPGAAPAQRPTYRQMVRHLRAEAHAGRMLPFVIEYRGQLVGQLTVAGITWGSMCSAHVGYWVDEAVAGRGVMPTAVAMVVDHCFRTLGLHRVEVCIRPENLPSRRVVEKLGFREEGLRPRYLHIDGAWRDHLVYALTAEEVPEGLLGRWHRARASGGSDRPREIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ60</accession>
    <name>A0A2G1XJ60_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.9</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_16085</name>
        <name evidence="7" type="ORF">CYQ11_11990</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6 7"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51267">
        <property type="protein sequence ID" value="PHQ51267"/>
        <property type="gene ID" value="BLA24_16085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13507">
        <property type="protein sequence ID" value="PPT13507"/>
        <property type="gene ID" value="CYQ11_11990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="282"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="406" mass="42754" checksum="183DDAF72686F923" modified="2018-01-31" version="1">MPEAVIVSTARSPIGRAFKGSLKELRPDDLTATIIQAALAKVPELDPREIDDLMLGCGMPGGEQGHNLARIVAVQMGMDHLPATTITRYCASSLQTSRMALHAIKAGEGDVFISAGVEMVSRSVNGSSDGIPGTHNPLFADAEARTAARAEKGGEGWHDPREDGLVPDAYMAMGQTAENLARLKGVTRQEMDEFGVRSQNLAEEAIEKGFWEREITPVTLPDGTVVSKDDGPRAGVTLEGVQGLKPAFRPDGLITAANCCPLNDGAAAVVIMSDTKARELGLTPLARIVSTGVSALSPEIMGYGPVEASRQALKRAGLTVGDIDLVEINEAFAAQVIPSYRDLGIDLDKLNVNGGAIAVGHPFGMTGARITGTLINSLQFHDKQFGLETMCVGGGQGMAMVIERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJD3</accession>
    <name>A0A2G1XJD3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_16240</name>
        <name evidence="3" type="ORF">CYQ11_11835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51291">
        <property type="protein sequence ID" value="PHQ51291"/>
        <property type="gene ID" value="BLA24_16240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13483">
        <property type="protein sequence ID" value="PPT13483"/>
        <property type="gene ID" value="CYQ11_11835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="143"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="264" mass="27182" checksum="B60B1B676CD1DBCD" modified="2018-01-31" version="1">MPEVTKPYVPGTPCWVDLVVPDQREALDFYRDLFGWQGEPGPPETGGYAVCALNGKAVAGIMTSMAQEGGSKPPPAWTTYLAVADADAAVAAVNANGGTPLTDVMDVLTLGRMAVVADSTGAVFGLWQAGDFFGAQVVNEPGSVVWNELNTADPGTAGSFYSAALGLTHSPMEELPGYSALKANGRVVGGMQSLEKSPPGSPSHWLTYFCVDDTDGTVDALTKAGGSVLKPPFDMVAGRMAVVQDPQGAVFALIDATGPSPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJE8</accession>
    <name>A0A2G1XJE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_15385</name>
        <name evidence="5" type="ORF">CYQ11_12690</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51356">
        <property type="protein sequence ID" value="PHQ51356"/>
        <property type="gene ID" value="BLA24_15385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16520">
        <property type="protein sequence ID" value="PPT16520"/>
        <property type="gene ID" value="CYQ11_12690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="3">
        <location>
            <begin position="374"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="527"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="676" mass="72483" checksum="A3465C5DB050EC73" modified="2018-01-31" version="1">MIGIWAESQRQHQRQQEARARTLAQEERERERLQRAQERELARQDRERRAAYRQAREAEARRRTEELEARVAALEGLLAAGCRAPAFTTAALGRSEELAPFDPGHLGTPVPVPDAGRYGFGSRAQYERDVQAARAAEDQRLRQLAAYRQQYDQWAAATLAEIRGYNAGLGELVAALRGGDADAVVEYFSAALYASDAWPDDFPHQVTAAYDPAARQLVLDWELPGSGVVPAVKSVRYMPTADEERETARPAGQCRALYRDVLAQCVLLAVRELFAADEFGALESVALNGFVDDHDPATGRRKQIVLASVTVSRAAFARLHLAQVSAVECLTEALGGLLSARPDQLAAVRPGRQPGDVGRGVVSHGGGDDPDLFEMDPIEFEALVAELFRARGMHAVMTQRSNDGGVDVEAMDPDPISGGRIIVQVKRYRKTVPPTAVRDLYGTVQAAGANKGVLVTTSGFGPGSYAFANGKPLTLVSGEELVELLGRHGLRGRLGGGAGARTTPAAAGRPEPEPAGEHNVLGMSWAGRVALDVCALVCRGGRVLSDDHFVFYNNPRTPDGSVRSVEPSPADKAAIRVAFEALPADADRLVLVAAIDPAVNPEADLSEFTDASIRLSDGSGAELGRLEVSDGRPGETALVLGSFRKRSGGDWDFVIGGRGYAGGLESLVQEYGIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJM5</accession>
    <name>A0A2G1XJM5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="19" type="ORF">BLA24_14610</name>
        <name evidence="20" type="ORF">CYQ11_13465</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51339">
        <property type="protein sequence ID" value="PHQ51339"/>
        <property type="gene ID" value="BLA24_14610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16538">
        <property type="protein sequence ID" value="PPT16538"/>
        <property type="gene ID" value="CYQ11_13465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PHQ51339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PPT16538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="351" mass="36713" checksum="5DBBF439FF3EDFCC" modified="2018-01-31" version="1">MQERHDAPLAPLTTFRLGGPATRLITAVTDAEVVEAVREADAAGTPLLIIGGGSNLVISDKGFSGTALRIATTGFSLDGTRLELAAGENWSDAVARTVEAGLAGVECMAGIPGSAGATPIQNVGAYGQEVSSTITEVVAYDRRSGETVVVPGAECAFSYRHSRFKQDPTRYVVLRVRFELEDADGLSAPVKYAETARTLGVEPGDRVPVARARETVLKLRAGKGMVLDAEDHDTWSAGSFFTNPILGAAEHEAFLARVAERLGPDVTPPAFAAGDGLVKTSAAWLIDKAGFTKGYGTGPARISTKHTLALTNRGSATTEDLLALAREVRDGVHEAFGVTLVNEPVTVGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJP5</accession>
    <name>A0A2G1XJP5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_15475</name>
        <name evidence="4" type="ORF">CYQ11_12600</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51359">
        <property type="protein sequence ID" value="PHQ51359"/>
        <property type="gene ID" value="BLA24_15475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16517">
        <property type="protein sequence ID" value="PPT16517"/>
        <property type="gene ID" value="CYQ11_12600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304738" evidence="2">
        <location>
            <begin position="31"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="425" mass="45480" checksum="5CDB03A84E1BA81B" modified="2018-01-31" version="1">MTRPLTVAVVAATLLALAPPAASRAGTAHAAAARATTTGRPSGPCALRTRTRGVSEGSRTPRGFAPSSGTVRAVTFFVDFPDARARLSPRQRYAEFFPAVADYYRTSSYGRLDYRSTPVLRWIHMARPYRSYGITRGTAFDPHRDDGYHAITREILAATGRSVDFRHYDLINVLAAPNAGPPATRDVRSVTFAGAPTGLRTHDGAHVKNVTFIWSRQTGDSPYRVLTHENAHSFGLPDLYYAAGGGGTRAPVGHWDPMAEDWGPSNDFLAWHKWKLGWLAPAQVHCLTRPGTRTVVLSPTSERGGPKLAVVPLSRTHALTLEARAPGRLDHAVCRPGVLITTVATHLPSGAGPVRAADATPGSPGCYTHDPNVSAPLSDAPYRAGQHYRVAGVTVTVLGQDARGNWHVTVTRRAAGAPGLSHLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJP8</accession>
    <name>A0A2G1XJP8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase AbiEii/AbiGii toxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13775</name>
        <name evidence="2" type="ORF">CYQ11_01470</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51401">
        <property type="protein sequence ID" value="PHQ51401"/>
        <property type="gene ID" value="BLA24_13775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11741">
        <property type="protein sequence ID" value="PPT11741"/>
        <property type="gene ID" value="CYQ11_01470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="436" mass="48151" checksum="6CA4DE7A2E5F9B2F" modified="2018-01-31" version="1">MTATPWEKFPYGPWDATAVVPQLPPDEATRAEKDLPHTLRPVPGEGVVQRPVYDPAVNHRRLGMRLSEPHFSDESAAGTWFAARRQALDHALAAVAGSPWAEHLVLRGSVLLTAWFGEAAREPGDLDFVVVPDTWRLDDARTDTMLDDLARATGELSRQAGSLVRVDAAGAVSDEIWTYDRVPGRRLVLPWTAGEARGTVQLDFVFNETLPAPPVRTEVPRHDEGAPAVVTAASPELSLVWKILWLVTDVHPEGKDLYDAALLAEHVQVPYELLERVLTAAGEPTSLAYVLNQASQADWFEFRKDRPDLRFEGDTCVMRLICALAPAFHPGEDGLHAQLAAAFGHITDALRDEREAGGMEAVATWFATRHVHALPALVSVRELLGRQDHTLRDAAEVIASFRDTRHDSDELIYVRAWRGDAYETAAWLETAESTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJU2</accession>
    <name>A0A2G1XJU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13380</name>
        <name evidence="3" type="ORF">CYQ11_01100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51496">
        <property type="protein sequence ID" value="PHQ51496"/>
        <property type="gene ID" value="BLA24_13380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11678">
        <property type="protein sequence ID" value="PPT11678"/>
        <property type="gene ID" value="CYQ11_01100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="330" mass="34673" checksum="C55E10918E6CF5DE" modified="2018-01-31" version="1">MREFRYHRAADMAGALALLETDPDARPLGGGTNLVDLMKTGVERPALLVDLRDLPLDRIETTTDGGLRIGATVTNSDLAAHPHVRRHFPALAQAVLAGASGQLRNMATVGGNLLQRTRCGYFTGAVAPCNKRAPGSGCAALTGEHRNHAVLGASPHCVAVHPSDMAVALAAFDAIVTYETVDGPGELPLAEFYRPVGNAPQLETALPQGALITGVRLPPAPIAAASRYRKVRERASYAFAIGSLAAALDVQEGVVREVRLAFGAVASRPWRARLAERALTGQPADAAAFAAAADAELAAARPLPHNGYKLPLMRNLVADVLTELAEEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKB8</accession>
    <name>A0A2G1XKB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetoacetate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_12410</name>
        <name evidence="6" type="ORF">CYQ11_04315</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000139">
        <property type="protein sequence ID" value="PHQ51666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51666">
        <property type="protein sequence ID" value="PHQ51666"/>
        <property type="gene ID" value="BLA24_12410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12224">
        <property type="protein sequence ID" value="PPT12224"/>
        <property type="gene ID" value="CYQ11_04315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="4">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="119"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="556"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="672" mass="74255" checksum="60B765FA6E5B1BFB" modified="2018-01-31" version="1">MTTAPHPADRPEPLRRPGQDRVARAQVTRFHAWAADRHGAPAPLPGDPAASYAALHRWSVDELETFWQAVTEWCDVRFTAPYERVLADRAMPGARWFPGATLNYAEHALRTAQDPARAQEPALLHVDETHDPRPVTWGDLRRQVGSLAAELRRLGVRPGDRVSGYLPNIPHAVVALLASAAVGAVWTSCAPDFGARSVLDRFQQVEPVVLFTVDGYRYGGKRHERADVVAELRAELPTLRAVVHIPLLGTPAPQGALEWDDLTAADTEPVFEQIPFDHPLWVLYSSGTTGLPKAIVQSQGGILLEHLKQLALHCDLGPQDRFFWYTSTGWMMWNFLVSGLLVGSTVVLYDGSPGHPDTAAQWRVAERTGATLFGTSAAYVMACRKAGVHPARDFDLSRVHCVATTGSPLPPDGFRWIHDEFHREGTEDMWIASVSGGTDVCSCFAGAVPTLPVHIGELQAPCLGTDLQAWDAHGKPVVDEVGELVVANPMPSMPLRFWNDPDGSRYRESYFDMFPGVWRHGDWITLTSRGTVVIHGRSDSTLNRQGVRMGSADIYEAVERLPEIRESLVIGVEQADGGYWMPLFVHLAPDATLDDELLDRIKSTIRRRLSPRHVPDEVIEVPAIPHTLTGKRIEVPVKRLLQGTPLEKAVNPGSVDNVELLGFYERLARERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKD8</accession>
    <name>A0A2G1XKD8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminopeptidase P family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Peptidase M24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_12530</name>
        <name evidence="4" type="ORF">CYQ11_17505</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000140">
        <property type="protein sequence ID" value="PHQ51651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51651">
        <property type="protein sequence ID" value="PHQ51651"/>
        <property type="gene ID" value="BLA24_12530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14424">
        <property type="protein sequence ID" value="PPT14424"/>
        <property type="gene ID" value="CYQ11_17505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="151"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="368" mass="39596" checksum="10C416EFD19B1D74" modified="2018-01-31" version="1">MSDVEFYAARMDRAVRSAVQEGLAGLVVTPGPDLVWLCGYAPPAVTERLTALLLVPGSRPQLLVPQLERADAERAPGAGALTVSGWTDGEDPYAEVAKVLAGQGRYGVSDNAWALHLLALQRKRPEAGFGALTEALPMLRAVKDAYELERLTAAGAAADAAFEAIVELPFAGRREHEVAADLDRLLRENGHEQVDFTIVGSGPNGADPHHEAGERVIEDGDMVVMDFGGLKGGYGSDTTRTVHVGEPSPEERKVHDLVREAQQAAFEAVRPGVACQDVDRAARQVIRRAGYGEYFVHRTGHGIGVTTHEPPYMVEGEHLPLVPGMCFSVEPGVYLPGRFGVRIEDIVVCTETGGRRLNNTARELRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKH8</accession>
    <name>A0A2G1XKH8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11560</name>
        <name evidence="3" type="ORF">CYQ11_02795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51720">
        <property type="protein sequence ID" value="PHQ51720"/>
        <property type="gene ID" value="BLA24_11560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11968">
        <property type="protein sequence ID" value="PPT11968"/>
        <property type="gene ID" value="CYQ11_02795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="426" mass="42925" checksum="EA532381F60A6BA0" modified="2018-01-31" version="1">MSELRAWWDALAAVVAGLAAMVVVAALGLWAAGAGDLPGGAFPSVVAATVVTAVGGTVDLAGGAGFLGRTGADLDVVPLSVTLAGALALAVVFLLPLRHHAVAGGAGLLARVARTAVLWLLALLFVALAARHTFRFSVGEEFLDELGAALGATPTVGFRAAVGPTLGYGLLWLLVLLAVAVAVSRKTPLPSRLLRFQDSVRPAAFALLVVLLAYVVLGLVLGVVVACTHGEPARTAAVLLLGLPNLAWIAFGVGLGGAWEGQAPHAIGLPMPHALAAVLRPRDGGPATVTVSSLAEQDGRAWLLVPLAALALLAAGFVAAVRSPAGTRSWHHAVRLGVATALTLLVVGLLTRVSARYGLSLLGIGDLGDDFGGTVSLRAQLPRLVGVGLLSGLVAGFLGGLLARRVRRRGEAPQPAGAEPGGPAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKJ4</accession>
    <name>A0A2G1XKJ4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_11810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51763">
        <property type="protein sequence ID" value="PHQ51763"/>
        <property type="gene ID" value="BLA24_11810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="484" mass="48895" checksum="429CA060F94965D3" modified="2018-01-31" version="1">MSGLLRLVPDEPEPCHDLAAAPAGRPRSTPRWAADPLDDLAQELAEVCAAAVHPDEIAAVLEADGLTGEQIAERYGRSDAFELAAELFARVPRGHPEPGPRPDPWRTGAGTCLLRSLVFTLPGLGYPLGAPLLAGPHDRFGLPAGTTALVAAGLAAWAWNQGLAHRAYLRLAAGGRAAAGRCLAVGAPLGALLATAAAPALRAAPGALALAAGQALYLAAATVLLVLGRERLLLLTLVPTATGGVVILLTQPPPVVGVTLLFATTGGALLAAAYETARALREGEPPAGAAPPSLLASVPYGLFGLGCGVLTTVAALGDLLVGRRAGAGGPEVIALTLSMGAAEWLLYRCRSRGLAALGASVTTAGLLLRAARVLVTCVAAYLAVLSVLVLAAEVLWHGGPPPFPLRLAALPALGAVLWTGLLLQAYGTAWTPALLCLGAAGAETAALTLRVSTPATFQLVICTGTAIALLAVATALLGRITTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKV3</accession>
    <name>A0A2G1XKV3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyl-gamma-aminobutyrate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_11840</name>
        <name evidence="2" type="ORF">CYQ11_03080</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51769">
        <property type="protein sequence ID" value="PHQ51769"/>
        <property type="gene ID" value="BLA24_11840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12016">
        <property type="protein sequence ID" value="PPT12016"/>
        <property type="gene ID" value="CYQ11_03080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="258" mass="26699" checksum="09BAE32DDB4D0A2D" modified="2018-01-31" version="1">MGPGRGEVKGKTIDKPTVGITTYQEDASWRGWHRHASLVPTDFVAAVTAAGGVPVLLPPSGAEPEAASVMAGLDGLLLVGGADIDPALYRAEPGPHTGTLAPERDTWESALLRLALEGDRAVLGVCRGMQLMNVLRGGTLLPHLPDLVGNDDHMPAEPVFASSRITLRTDALPGSLLGAESDLPCFHHQAVDTLGTGVVATGWSADDVVETISLTGHRFALGIQGHPEVGPSRPVFEAFVAAAAAHRAAREQGGVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLR9</accession>
    <name>A0A2G1XLR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_09610</name>
        <name evidence="2" type="ORF">CYQ11_28220</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52183">
        <property type="protein sequence ID" value="PHQ52183"/>
        <property type="gene ID" value="BLA24_09610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16849">
        <property type="protein sequence ID" value="PPT16849"/>
        <property type="gene ID" value="CYQ11_28220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="23008" checksum="63EC204A3A9C7DF6" modified="2018-01-31" version="1">MTAPSTGRQVIRIDGTRPPSAGLVAAVTAACERVEDRGTPTRVVVEASGAPDGEWTRGLTPGLVGKWERALRRLERLPAATVAVATGDCGGTALDALLAADHRVVSPDTRLVLPVAAGAPWPGMALYRLVREGGGTGAVRRAILFGAPLEAADALALHLVHAVSDDLPGALEAADGLAGRVPGAELAIRRQLMLDASSVGFEEALGAHLAACDRALRQTDAGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLY0</accession>
    <name>A0A2G1XLY0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_08595</name>
        <name evidence="8" type="ORF">CYQ11_03850</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52216">
        <property type="protein sequence ID" value="PHQ52216"/>
        <property type="gene ID" value="BLA24_08595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12149">
        <property type="protein sequence ID" value="PPT12149"/>
        <property type="gene ID" value="CYQ11_03850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="407" mass="40556" checksum="E75FD4239843FE0A" modified="2018-01-31" version="1">MPTLNKIRTALSRERGPLAGDPGLRRLRTALTLFFALDGFLFAGWVVRIPAIKEQTGASAGALGLALLGVSGGAVATMMMTGRLCRRFGTHPVTVAAGALMSLSIALPPLTHSALALGLVLLCFGAAYGGLNVAMNSAAVDLVAALRRPVMPSFHAAFSVGGMLGAGLGGLVAGQLSATRHLLVLTAVGLAVAAAAGRTLLAHPAPRLPGAPAAPGRAEDGARTSGRDRRLVAVFGLIALCTAYGEGALADWGALHLEQDLAAHAGVAAVGYSVFALAMTVGRLTGTALLERLGQTRVLVAGGLTAALGMLLGSLAPTVWAALAGFAVTGLGLANIFPVAVGRAGELTGPAGVAAASTFGYGGMLLGPPAIGFLADWFSLPVALTTVAGLAGAAALIAYATRGAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XME0</accession>
    <name>A0A2G1XME0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_07605</name>
        <name evidence="2" type="ORF">CYQ11_00035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52407">
        <property type="protein sequence ID" value="PHQ52407"/>
        <property type="gene ID" value="BLA24_07605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16252">
        <property type="protein sequence ID" value="PPT16252"/>
        <property type="gene ID" value="CYQ11_00035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009492">
        <property type="entry name" value="TniQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06527">
        <property type="entry name" value="TniQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="289" mass="31877" checksum="1FB2A507E3DB4E06" modified="2018-01-31" version="1">MPSAAPGVLRVRPLTGEATASYVHRLATAYRLTLPQLLDGAGITLSGHGTLPTAELHLSPAACHNLAALTRIPLPHLTRALPRLAPNDDAHHIATAAHWKRHEAAQQPVRACTLCTRHRSHDATDTAWTHRPPHRLVCPRHHQATPDPRLTSTVRTWAVPELAAAHHAHQRLLRHPRAATAWTAARAITTRWYDHQQHLTDRSHTRLNQLYATNPHLTTTGSASPALLARDLITYPETVALARALATLPNRPHRDTGNALNLIAHRLGLPRLPLNANDPLQAFLTHTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMU3</accession>
    <name>A0A2G1XMU3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_07080</name>
        <name evidence="7" type="ORF">CYQ11_27235</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52530">
        <property type="protein sequence ID" value="PHQ52530"/>
        <property type="gene ID" value="BLA24_07080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16067">
        <property type="protein sequence ID" value="PPT16067"/>
        <property type="gene ID" value="CYQ11_27235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="519"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ52530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110922" checksum="9501FA3D886AD001" modified="2018-01-31" version="1">MHNDRSITEARLTRVLEERIRPAVYPESVPLSVSVWHAPGEPVSVAEGLAAERTPVEAGTEWGPAWGTSWFTVSGTVPREWAGRTVEALLDLGFDDNMPGFQCEGLVYGPDGSPLKGLNPRNQWVRVSERARGGEQVLLHVEAASNPVILDYRPFRPTELGDRETADDAPRYRLARMDLAVFERTVWELVQDLEVLGGLMAELSVDSPRRWEVLRAVERALDAVDLQDVGGTAAGAREELRGVLSSPAHASAHRISAVGHAHIDSAWLWPLRETVRKVARTTSNMTALLEDEPDFVYAMSQAQQFAWVKEHRPEVYARVKKAVAEGRFVPVGGMWVESDTNMPGSEALARQFVHGKRFFLEEFGIETEEVWLPDSFGYSAALPQLVRLSGSRWFLTQKISWSRTNKFPHHTFWWEGLDGTRVFTHFPPIDTYNSQLSGAEVAHAVRNFQEKGGATRSLAPTGWGDGGGGTTREMLARAKRLADLEGSARVVFEKPSAFFEKAHAEYPHAPVWVGELYLELHRATLTSQARTKQGNRRCEHLLYEAELWAATAAVRTGFPYPYEALDRLWKTVLLHQFHDILPGTSIAWVHREAARTYEETAAELEALIARALAALAGDGASGGTVVFNAAPHERAGAAAHGAVAAGRPAPEPSTAQPREGGGFVLRNAALRVEVDGRGLVVSVYDTGADREAVPPGAAANLLQLHQDFPNMWDAWDVDPFYRNTVTDLTDAETVELAEDGVTVRVVRAFGTSRVVQRLSLPAGVRRLDVETEVDWHETEKFLKASFPLDVHTDRVAAETQFGHLHRPTHANTSWDAAKFEACAHRFVHLQEPGWGVALVNDSTYGYDVTRAARAEDGGTTTTVRLSLLRAPRFPDPRTDQGVHRFRYALVPNASVGDAVREGYRVNLPERRVPGERGVLPLARVDDDAVVVSAVKLADDGSGDVVVRLYESLGGRARARLTPGFAMASAHVCDLLERPLEAVPAEGEGIRLALRPFQILTLRLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMU4</accession>
    <name>A0A2G1XMU4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(Fe-S)-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07305</name>
        <name evidence="3" type="ORF">CYQ11_27460</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52567">
        <property type="protein sequence ID" value="PHQ52567"/>
        <property type="gene ID" value="BLA24_07305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16105">
        <property type="protein sequence ID" value="PPT16105"/>
        <property type="gene ID" value="CYQ11_27460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="26567" checksum="5E51DCC87C98BAC4" modified="2018-01-31" version="1">MRVGLFVTCVNDTLYPGTGRAVVALLERLGVRVDFPAAQSCCGQPLFNTGYRHRAEPLVLRQAAAFRDHDYVVTPSASCAAMIRDAYPRIAARAAAEGRASSALAEAADHAAPRTYELTEFLVDVLGVTDVGARFPHTVTYHPTCHGLRALGLGDRPRRLLEQVGGLELRELEGAEECCGFGGTFCVKNPAVSAAMGADKARAVTATGAEVVCAVDNSCLMHLGGVLSRQGSPVRPLHLAEILAATEEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMW0</accession>
    <name>A0A2G1XMW0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_07445</name>
        <name evidence="5" type="ORF">CYQ11_27595</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52594">
        <property type="protein sequence ID" value="PHQ52594"/>
        <property type="gene ID" value="BLA24_07445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16131">
        <property type="protein sequence ID" value="PPT16131"/>
        <property type="gene ID" value="CYQ11_27595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="209" mass="22462" checksum="B81609B7EF1D8FA8" modified="2018-01-31" version="1">MQDEYRTVEHEGVHEIEISRSRFICALAPAATEEEAQAFVACVRKEHPTARHHCWAYVIGADGSVQKASDDGEPGGTAGVPMLQMLVRRETRYVVAVVTRYFGGVKLGAGGLIRAYGGVVGEALDTLGTVTRRRFRLATVGIDHQRAGKLENELRATGRAVREVTYGADVSIEIGLPEADVAAFRAWLADTTAGAARFELGGEAYGDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMX7</accession>
    <name>A0A2G1XMX7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_07085</name>
        <name evidence="8" type="ORF">CYQ11_27240</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52531">
        <property type="protein sequence ID" value="PHQ52531"/>
        <property type="gene ID" value="BLA24_07085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16068">
        <property type="protein sequence ID" value="PPT16068"/>
        <property type="gene ID" value="CYQ11_27240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="Glyco_hydro_85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="PTHR13246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304934" evidence="5">
        <location>
            <begin position="33"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_85" evidence="6">
        <location>
            <begin position="116"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ52531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT16068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="690" mass="73189" checksum="84E67B6FE4CB0BAE" modified="2018-01-31" version="1">MSERPTRRAVLAAGAAGLAAGALPAAAASAGAAEDLQPYASYWFPDGLPSGTPAPGVTWRSLSAWRERDDADLPFNRATVPLAPRFTPPPPNATARPDQARVCALAAFAPTSGNPSQGSASADFYALSHWAYLDELVFWGGSAGEGLVLAPNAPVVDAAHRNGVRVLGTVFLPPAAYGGQLRWTHDLVRQGPDGAFPLADKLVEVARAYGFDGWFLNAETGGGDARLGARMRDFVAYLRARGASGGRALRVTWYDAMTVSGDIAWQNELNERNAPFFRAADGMFLNFGWSRSGLVSSGELARSLGRGPFELWAGIDVEARGWDTPVDWDALVPAGGPHLASYGFYRPEWTWRSLPEGGRAPAAFHARDDRFWSGAALDPACPESGPWRPAAATVVDRSTLIALPFATTFNTGHGLGWYDRGRRVAGDAWNHLGLQDRLPGRRWVVHTAGDRPFVGFDFADAWRGGSSLLVTTQAAGAATVELYAARLPLSEATVVELAHRTDPGSAAVRVEVALALEERPDRFAYLPAGTLPAGGRGWTTATLRLGPLGRAGGTARVLGVRLTAPDGGGVRWRLGELAVHDAVPAAPGRPRAVTVSASTRNADGTAALRLRWDPPAAAGTGRRAPGPVRHYELRQALPGGGFRFLGGTCGHAYYVPALRRTAGEAATRVDVCAVDELYSVSAPASVMFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN07</accession>
    <name>A0A2G1XN07_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-beta hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_06410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000079">
        <property type="protein sequence ID" value="PHQ52635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52635">
        <property type="protein sequence ID" value="PHQ52635"/>
        <property type="gene ID" value="BLA24_06410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="198" mass="20470" checksum="0A8B03EA9927A1A5" modified="2018-01-31" version="1" fragment="single">MVRIALFGATGTIGSRVLREALERGHQVTAVVRDPAKLTERHPGLKVTTGDVLDPASVAAAAEGQDVVVSAVGGGDGPGHVATIEPAAKSLVAGVRSLGAMAPRLIAVGGAGSLRTPAGTKVWDAEGIPEFLLQIMHAHGDALDYYRTVSDVRWTNLSPAGTIEPGERTGAYRTALEDLVVDEQGVSRISAEDYAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNP7</accession>
    <name>A0A2G1XNP7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04610</name>
        <name evidence="3" type="ORF">CYQ11_28920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52858">
        <property type="protein sequence ID" value="PHQ52858"/>
        <property type="gene ID" value="BLA24_04610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11486">
        <property type="protein sequence ID" value="PPT11486"/>
        <property type="gene ID" value="CYQ11_28920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="99" mass="10418" checksum="021FDF1F21AA9DD0" modified="2018-01-31" version="1">MNTGHARAADRPAAPFEVTFDGRPLVALPGQTVGAALLAAGLRSWRTTRRTGRPRGLFCGIGVCFDCLITVNGQPSLRACLTEARPGDVVTTQEGTGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNV6</accession>
    <name>A0A2G1XNV6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04710</name>
        <name evidence="3" type="ORF">CYQ11_28820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52871">
        <property type="protein sequence ID" value="PHQ52871"/>
        <property type="gene ID" value="BLA24_04710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11469">
        <property type="protein sequence ID" value="PPT11469"/>
        <property type="gene ID" value="CYQ11_28820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="95" mass="9801" checksum="65685D617918BC15" modified="2018-01-31" version="1">MNSPVVTGKRGRSRTEFRRDADLMAVTSFVVGLVGLLVFNLVLGPCALALGAVALARGTGRRFRACLGLALGCADLVLFVALAGAQGTPSWHMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP02</accession>
    <name>A0A2G1XP02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04665</name>
        <name evidence="3" type="ORF">CYQ11_28865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="strcj-a0a2g1xp02">
        <property type="family name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52967">
        <property type="protein sequence ID" value="PHQ52967"/>
        <property type="gene ID" value="BLA24_04665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11476">
        <property type="protein sequence ID" value="PPT11476"/>
        <property type="gene ID" value="CYQ11_28865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305613" evidence="1">
        <location>
            <begin position="33"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="444" mass="49300" checksum="8A194D1E897606A6" modified="2018-01-31" version="1">MRNTTPRRPRKTLLLAALACLLGAGPVHPARAHTADDDIRARVEAVPGMRVIEEESAPPGYRSFTLGFRQPVDHRHPAAGTFEQKLRLLHRSAERPVVVYNSGYALGKAAPGRTEPAELLDGNQLSVEHRFFGDSRPSPVDWSKLDIWQAASDQHDLVQALKKVYRTPWISTGGSKGGMATVYHRRFYPHDVDGSVVYSAPDNVDDRDDSAYDAFVERLGTPACREALKSAQREVLTRREAMAARYARWAEGAGLTFRTVGSADRALELAVLRVPLMFWEYGDESRCAKVPGPSAPDDDVYAWLDDVSGLKLYTDQSLEAYQPYFYQLGTQLGYAQFAAPHLAGLLRHPGVQEVRTYVPRDVPLRFQPQAMNDVDQWVRRHGSRLLFVYGGNDPASAEPFRLGGGSRDSAVFVAPATNHRARIAGLRPEDAARATASLRRWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP09</accession>
    <name>A0A2G1XP09_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1876 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05225</name>
        <name evidence="3" type="ORF">CYQ11_28305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52950">
        <property type="protein sequence ID" value="PHQ52950"/>
        <property type="gene ID" value="BLA24_05225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11388">
        <property type="protein sequence ID" value="PPT11388"/>
        <property type="gene ID" value="CYQ11_28305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="95" mass="10113" checksum="51CE343571C09C61" modified="2018-01-31" version="1">MPHTTEWNVRLRLSEDEGTTKAQVVLETGTTSLTGRGTAQRAPGDKDVPEIGDEFAVGRALRDLGDKLLSTAAHDVEAVGAAPEPRTSPSYGWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP45</accession>
    <name>A0A2G1XP45_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_05025</name>
        <name evidence="3" type="ORF">CYQ11_28505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52983">
        <property type="protein sequence ID" value="PHQ52983"/>
        <property type="gene ID" value="BLA24_05025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11504">
        <property type="protein sequence ID" value="PPT11504"/>
        <property type="gene ID" value="CYQ11_28505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045991">
        <property type="entry name" value="DUF5947"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19372">
        <property type="entry name" value="DUF5947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="214" mass="23418" checksum="94B5418E7BBE2273" modified="2018-01-31" version="1">MSAARTASPRLRELARRPAPEPVNAPGERCDLCAEPLADDHRHLLDASGGHTVLCACRACSLLFDRSEAGGRHYKLLPRRRLRLDGFTVDDALWASLGIPVGLAFFVRDDASGRTTVGYPSPLGTTRSELDAAVWHDLARGHPALAELAADVEALLVHRVPGAPPQHWIVPLDDCYRLVAVVRAHWKGLAGGPEVWTRIQRFFTGLARPEPAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP76</accession>
    <name>A0A2G1XP76_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family virulence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04235</name>
        <name evidence="3" type="ORF">CYQ11_14025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53034">
        <property type="protein sequence ID" value="PHQ53034"/>
        <property type="gene ID" value="BLA24_04235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13859">
        <property type="protein sequence ID" value="PPT13859"/>
        <property type="gene ID" value="CYQ11_14025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="126" mass="13928" checksum="6BCBF6723C058B27" modified="2018-01-31" version="1">MRVIAFDHLVLNVSDVERSLAFYTGPLGLEPVRVDEWRAGKVSFPSVRVSPTTIIDLVEGERGESNVDHICLVVEPLDWQSVIDAGTFTVVDGPGKRFGARGDAQSVYVVDPDGNTIELRWYPQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPA6</accession>
    <name>A0A2G1XPA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000063">
        <property type="protein sequence ID" value="PHQ53031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53031">
        <property type="protein sequence ID" value="PHQ53031"/>
        <property type="gene ID" value="BLA24_04220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="59" mass="7131" checksum="9D18D46570EDF090" modified="2018-01-31" version="1">MPAGIRGRGRSWRTPRWPPRRRRRRPRTPSSRRVPWTISGTTRTWTTGWWARRRACTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPB3</accession>
    <name>A0A2G1XPB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000054">
        <property type="protein sequence ID" value="PHQ53072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53072">
        <property type="protein sequence ID" value="PHQ53072"/>
        <property type="gene ID" value="BLA24_03830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="270" mass="29073" checksum="4A964AC6CF1B3A2F" modified="2018-01-31" version="1" fragment="single">VGGDGKLADRVGTGHFGQTSYLAFNPAVKPFDNPKVRQAISYAINRTSVVNAAGGSSLAEPATTFLRTRSPSATRRTTTSRGAKGDPGKARELLKEAGYDNGLEITLTHSTAQNFETSPEIATAVQAALKEAGITVKLEGLEDNDYDEKIHSFAKQPGLFIAHWGADWPSGGPFLAPVFDGRQIVKDGANFNTARLDDPKVNDEIDEINKITDHDAAAARWGALDKRIGEQALTVPLFHPVYKRLYGKDVKNVVISDWTGVLDVSQVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPH8</accession>
    <name>A0A2G1XPH8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03355</name>
        <name evidence="4" type="ORF">CYQ11_16930</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000040">
        <property type="protein sequence ID" value="PHQ53120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53120">
        <property type="protein sequence ID" value="PHQ53120"/>
        <property type="gene ID" value="BLA24_03355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14327">
        <property type="protein sequence ID" value="PPT14327"/>
        <property type="gene ID" value="CYQ11_16930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT14327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="281" mass="27636" checksum="81D902ACEF18B1EA" modified="2018-01-31" version="1">MGSLRNPIGPLPSSIYWRRRAVALGLLGILVLLAVWFLTMGGDGGSKGAQSDGSNGQGPSDATITPGPTPSGPLISQRPGGRGDSGGGGTDDRNGGGSGSGGSAGTGGAGGGGGAGGAGGPAAGGFGGGPGLQVAGEGKAVATGSPLPDCVPGAVRLSLRSVKDSYRADEKPRFELVVKNTGGGACKVNFGATAALLKITDSKGEEHVWASDDCPRGNGAVLFEVPGAGETKRTLEWDRRRSAPRCATPTGAAAAAAPGTYRVEIKVAGVTERVEFTLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPS3</accession>
    <name>A0A2G1XPS3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">BLA24_02735</name>
        <name evidence="10" type="ORF">CYQ11_05030</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53247">
        <property type="protein sequence ID" value="PHQ53247"/>
        <property type="gene ID" value="BLA24_02735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12340">
        <property type="protein sequence ID" value="PPT12340"/>
        <property type="gene ID" value="CYQ11_05030"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="173"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ53247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="339" mass="36582" checksum="34CF42E210CDFE02" modified="2018-01-31" version="1">MLHLSGGSPRTPGHLISAADLSRDDAVLILDTAEEMARVADRPIKKLPTLRGRTVVNLFFEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTALTLEAMGADAVVIRHHASGAPYRLATSGWIDGVVVNAGDGTHEHPTQALLDAFTMRRRLIGPDAGLGQDLSGRRITIVGDVLHSRVARSNVHLLGTLGAEVTLVAPPTLVPVGVESWPCEVSYDLDQVLPKSDAVMMLRVQRERMNAAFFPTEREYARRYGLDGDRMARMPEHAVVMHPGPMNRGMEITAEVADSDRCTAVEQVANGVSIRMAVLYLLLGGSEPAVTNNATARTEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQA6</accession>
    <name>A0A2G1XQA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00365</name>
        <name evidence="3" type="ORF">CYQ11_07375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53424">
        <property type="protein sequence ID" value="PHQ53424"/>
        <property type="gene ID" value="BLA24_00365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12728">
        <property type="protein sequence ID" value="PPT12728"/>
        <property type="gene ID" value="CYQ11_07375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="129" mass="14240" checksum="9C9D5105E5B55B7B" modified="2018-01-31" version="1">MIATMQCTVIDCPDPLALARFYAAVLGWRVGDEDSDPAWVWLTDPATGQRLAFQGVEEYHPPHWPDPARPQQMHLDFDVPERADVERAKGEVVALGATFLHDSGGEKRGFLVFSDPAGHPFCLCYGQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQH0</accession>
    <name>A0A2G1XQH0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_00720</name>
        <name evidence="6" type="ORF">CYQ11_07730</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53488">
        <property type="protein sequence ID" value="PHQ53488"/>
        <property type="gene ID" value="BLA24_00720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12793">
        <property type="protein sequence ID" value="PPT12793"/>
        <property type="gene ID" value="CYQ11_07730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ53488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="239" mass="25118" checksum="C5A1AB3C7BA8B266" modified="2018-01-31" version="1">MTDRRTQLADNLARVEERISAACAAAGREREEVTLIVVTKTYPASDVRLLSELGVRHVAENRDQDAAPKAAECSDLPLTWHFVGQLQTNKVRSVVNYAGLVHSVDRSRLVTALSAAAVRAGRELDCLIQVALDAESGARGERGGVAPDGVLDLADEIAAAEGLRPVGLMTVAPLTGPFADRPRAAFGRLMEIATDLRATHPAANMVSAGMSADLEDAVAAGATHVRVGSAVLGVRPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQL0</accession>
    <name>A0A2G1XQL0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_00940</name>
        <name evidence="4" type="ORF">CYQ11_07950</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53528">
        <property type="protein sequence ID" value="PHQ53528"/>
        <property type="gene ID" value="BLA24_00940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12833">
        <property type="protein sequence ID" value="PPT12833"/>
        <property type="gene ID" value="CYQ11_07950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="174" mass="18577" checksum="6344454CC055C54D" modified="2018-01-31" version="1">MAEHDADRDRDESRDPLDEDRAWAELVAAYGEQPDPEKGRWPATGDGGDEKPPSPERADGPERPGSFIVYAPGVGPRDGGTPPVGAAEDETDEGHFVPPEPPPLPAGDVTSRFAWIAVLGGPLLLLVMVLLRQELTWWITTLGVGGFLGGFATLVLRMKDEDDDDGDPGRGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQT8</accession>
    <name>A0A2G1XQT8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BLA24_01065</name>
        <name evidence="13" type="ORF">CYQ11_08075</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53551">
        <property type="protein sequence ID" value="PHQ53551"/>
        <property type="gene ID" value="BLA24_01065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12856">
        <property type="protein sequence ID" value="PPT12856"/>
        <property type="gene ID" value="CYQ11_08075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ53551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="132" mass="14650" checksum="70F510ABDF6B57E0" modified="2018-01-31" version="1">MKIQGRMFIWLSVFILAMAIVYGVWAKEPAGATALFLAFGLTIMVGYYLAFTARRVDVGAQDDKNADVADDAGELGFFAPHSWQPLSLAVGGALAFMSICFGWWLMYFSAPVILVGLFGWVFEFYRGENQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQW9</accession>
    <name>A0A2G1XQW9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_00240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000009">
        <property type="protein sequence ID" value="PHQ53581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53581">
        <property type="protein sequence ID" value="PHQ53581"/>
        <property type="gene ID" value="BLA24_00240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="66"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ53581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="276" mass="29656" checksum="27E51D8C5A34995E" modified="2018-01-31" version="1">MLVTTYSPTPSGPATFHPHARQTSYLADGDQADATDGAPFVTRTTYWRYLTGVDVWNSEAHGSVAVLGDSITDGVSATVDADHRWTDYLAARLNSEPGAPRYGVLNEGISGNRVLLSGQGASPTANPSALERFDRDVLSRAGVRVVVVELGINDILRQPQQADPGRITAGLRQLVDRAHLRGLRVIGSTLTPFGGRTGAGPQHEAVRQGVNEEIRAGRVFDDVVDFDQALRDPEQPQRLLPAYDCGDHLHPSDAGYRAMADTLDVEKLKAQPAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X938</accession>
    <name>A0A2G1X938_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_30180</name>
        <name evidence="16" type="ORF">CYQ11_23270</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47785">
        <property type="protein sequence ID" value="PHQ47785"/>
        <property type="gene ID" value="BLA24_30180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15410">
        <property type="protein sequence ID" value="PPT15410"/>
        <property type="gene ID" value="CYQ11_23270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="118"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="496"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="588"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="680"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="772"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="864"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="956"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1048"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="1359"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1710"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1596"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1280"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ47785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT15410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1830" mass="194954" checksum="122EDE1F52A4F80A" modified="2018-01-31" version="1">MESGAAARGVSTRAKGGRSRPNGTTEVDAAALNRLRSALEAMRDGNFRKRLTVSGDGVMAEIAAVFNEVADRNLQLTGELARVRRVVGREGKLTERLEVGACEGAWASAIDASNALVDDLVRPVSEVGRVLSAVAEGDLEQRMDLRSQGADGSAHPLRGEFLKVGRTVNGLVDQLSAFTDEVTRVASEVGTEGKLGGQARVRGMSGSWKDLTDSVNTMASRLTAQVRDIALVTTAVAKGDLSRKVTVHVAGEMLELKNTVNTMVDQLSSFASEVTRVAREVGTEGELGGQAQVPGVAGVWKDLTDSVNLMAGNLTAQVRGIAQVTTAVANGDLSQKVTVSARGEVAQLAETINQMTETLRTFADEVTRVASEVGAEGRLGGQAQVPGAAGTWKDLTDSVNTAFRNLTGQVRDIAQVTTAVANGDLGQKVTVDVSGEMLELKNTVNGMVDQLQSFGAEVTRVAREIGVEGELGGQAQVPGAAGTWKDLTDSVNTAFRNLTGQVRNIAQVTTAVANGDLSQKVTVDVSGEMLQLKNTVNTMVDQLSSFADQVTRMARDVGTEGRLGGQARVDGVSGTWKELTDSVNFMAGNLTSQVRQIAQVTTAVARGDLSQKIDVDARGEILELKNTINTMVDQLSAFAEQVTRVAREVGTDGRLGGQAQVPGVAGVWRDLTDSVNGMAGNLTAQVRNIAQVATAVARGDLSQKIDVDARGEILELKNTLNTMVDQLSSFADQVTRVAREVGTEGILGGQAEVQGVSGTWKDLTQSVNFMANNLTSQVRNIAEVTTAVAKGDLSKKITVDAKGEILALVTTVNTMVDQLSDFAEQVTRVAREVGTEGQLGGQARVRDVTGIWKDLTDNVNLMANNLTSQVRNISQVAGAVANGDLTKKITVEARGEVAQLADTVNTMVTTLSSFADEVTRVAREVGTDGILGGQARVPGVSGTWKDLTESVNSMASNLTGQVRNIAMVTTAIAQGDLTKKIDIDARGEILQLKTTINTMVDQLSSFADQVTRVAREVGTEGQLGGQARVRDVDGTWRDLTESVNEMAGNLTRQVRAIAEVATAVTRGDLNLKIDVDAAGEILELQDNINTMIANLRETTLANKEQDWLKGNLARISGLMQGRRDLEDVAGLIMSELTPVVSAQHGAFFLAMPTEPQDGESGEDAYELRMLGSYGYSMGSMPTSFRPGESLIGTAAKEKRTILVENVPPGYLKIASGLGEAPPAHVIVLPVLFEGQVLGVIELASFQPFAQIQKDFLNQIAEMIGTSVNTISVNTKTEVLLKQSQELTEQLRERSAELENRQKALEISNAELEEKSERLARQNRDIEVKNTEIEEARQVLEERAEQLAVSMRYKSEFLANMSHELRTPLNSLLILAKLLADNADGNLSPKQVEFADTIHGAGSDLLQLINDILDLSKVEAGKMDVSPTRIALVQLVDYVEATFRPLTAEKGLDFSVRVSPELPATLHTDEQRLLQVLRNLLSNAVKFTDTGAVELVIRPAGADVPDSIREQLLEAGSLRDADADLIAFSVTDTGIGIAQSKMRVIFEAFKQADGTTSRKYGGTGLGLSISREIARLLGGEIDAASEPGRGSTFTLYLPLNPGELPPQGYPQAGDGSAAHPQESSPEAGGATEGDVSSARQAAGMFLRRRRAAQAASRMPALPGPGQGGEIVPGARAALAASGQHEPGTAEPYAEAGDHVHAGFSGSFQGEKVLIVDDDIRNVFALTSVLEQHGLSVLYAENGREGIEVLEQHDDVVVVLMDIMMPEMDGYATTAAIRRMPQFAGLPIIALTAKAMKGDREKSIDAGASDYVTKPVDTDHLLTVMEQWMRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9E0</accession>
    <name>A0A2G1X9E0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_30450</name>
        <name evidence="3" type="ORF">CYQ11_23545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47836">
        <property type="protein sequence ID" value="PHQ47836"/>
        <property type="gene ID" value="BLA24_30450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15461">
        <property type="protein sequence ID" value="PPT15461"/>
        <property type="gene ID" value="CYQ11_23545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ47836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="192" mass="20855" checksum="05191F6981E2A54B" modified="2018-01-31" version="1">MALGFAPPLPADSAPRLGRLLAPDEWAAADVPLLRNPREVVTGLHDRHLPVPSTAVVAVLHPDERLAASASFIRRAGEADGWELRNALLTRLRQVIPHDLRLRSPVRTAVLLYCREGEPRWTEEDGAWMWALRDACTLHGLRCGAYVILTRAGWQVLGEGRSGRQPRAEARRAAPAGSGGGAPAALRHTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9F8</accession>
    <name>A0A2G1X9F8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M23 family peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30575</name>
        <name evidence="5" type="ORF">CYQ11_23670</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47856">
        <property type="protein sequence ID" value="PHQ47856"/>
        <property type="gene ID" value="BLA24_30575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15481">
        <property type="protein sequence ID" value="PPT15481"/>
        <property type="gene ID" value="CYQ11_23670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304529" evidence="2">
        <location>
            <begin position="45"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="268" mass="28027" checksum="3A941D33AA8BEAFA" modified="2018-01-31" version="1">MSFTRPSGKHRRPSRAVRVSANVAGIATLTAAGVVAGVAAPAFAASGDDSQRPEDTGLTQAIVMGDVMADTIDAQAETQRSAADEAAARSHAEAAAKQKAADVKQRYEEAKRKLEEEREAKERAAREEERKRLNTFVMPITGSYVSTSYKASSGLWSSGSHTGVDFHADSGTSVHAVGAGTIVEAGWGGAYGNNVVIKHNDGTYTQYGHLLTIEVSVGQSVTAGQEIGVSGATGNVTGPHLHFEARTGATYGTDIDPVAYLRSHGVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9L0</accession>
    <name>A0A2G1X9L0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02680 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_30865</name>
        <name evidence="4" type="ORF">CYQ11_23965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47906">
        <property type="protein sequence ID" value="PHQ47906"/>
        <property type="gene ID" value="BLA24_30865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15531">
        <property type="protein sequence ID" value="PPT15531"/>
        <property type="gene ID" value="CYQ11_23965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013496">
        <property type="entry name" value="CHP02680"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02680">
        <property type="entry name" value="TIGR02680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="745"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="924"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1385" mass="150461" checksum="56A3A2DA9427F476" modified="2018-01-31" version="1">MTVLPDPAPGRWRTLRIGLVDLFYYDTEEFWFRDGRLLLRGNNGTGKSKVLALTLPFLLDGDLSARRVEPDADPGKRMEWNLLLGGQHPHPERLGYTWIEFGRRDEESGRAHFRTLLCGLKAVTGRGIARHWYAVTDQRVGEELSLLDTTGTALSRDRLAEAVAGHGMVYDQAKAYRRAVDEALFGLGERRYAALVDLLIQLRQPQLSKRPNETALSRALTEALPPMDQAVIADVAEAFHSLDEEKEELRAASEAERAASAFLGYYRRYARVATRRRARLPRSEHARYEQLHRDLTQARAEREEAERHRTDAAERIARLEETAVRLTAQDAALRTGPEMRSARELEQAAADARRTAEEKRRAEGDREQAAQAHSRALGRLASAEGRLTAADQRVENALGQAQETARAARLGDVLGDGTAPGAELRHAAEEAVARRRRTLDHVEKLVAQTEHAVGERRAAARHLDDAQAEATHTGERKAQAEAAAAEAGRELVDAVREHLDRCAELAVADRTGLLDALQDWSTHLHGPSPARERVAAAHRTLAAGLADQTAELGRRLAELADRHTAVQGDLVELEAGAQRGPAAPHTRTPGLRDRAPGAPLWRLIDFRDHVTPGQRAGLEAALEASGLLDAWVCPDGTVLEAGGHDVLLSPPAPDAPLSGPVLADLLRPAVDHGDPRAVQVGERAVSAVLAAIGLGDEDATSPEAPRTWVAADGRFRIGALTGSWSKESAVYVGEGAREEARRARITALRGELDALAESTARLEAQNASVTERRRRLDAELAGLPDDAGLRHAHAVAAAAADAAHRARERQEERAAELAEAARREAEAAAELNETADAVHLPTDRTALAAVRQALADHTAALAALWPALRERDEARRAVADEQAETARTGERVTELDGRMAEAARRAAAADEHHTTLRSTVGAAVADLERRLTETADALATCERDQKQARHDYSAADRRTGRAEGRIDQLEKDVHDAAAARAEAIAALQRFAATGLLAVALPEVPMPPMDGGTWAATPAITLARAIESELSDTDDSDGAWERVQKRLSEEYKKLQDVLSRGGHGATARMTEDGMVVDLVYQGRERAVPELAEALAAEVQELTRILSAHEREILETHLLTEVAGTLQELIGTAERQVHAMNAELEQRPTSTGMKLRLLWRPSRKAPAGLAQARARLRQSADAWSAEDRAAIGEFLQAQIARAQADDAAGSWLDVLTTALDYRTWHEFGIERHQHGTWVPATGPASGGERVLAVSVPLFAAASSHYATAGPYAPRLVTLDEAFAGVDDDSRAKCLGLLHAFDLDVVMTSEREWACYPQVPGIAIAQLSRVDDIDAVLVTRWQWDGTRRERVTDPGYPMATVPAPARSPGTAESEPAGTAAPDQDTLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9N3</accession>
    <name>A0A2G1X9N3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31010</name>
        <name evidence="2" type="ORF">CYQ11_24110</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47932">
        <property type="protein sequence ID" value="PHQ47932"/>
        <property type="gene ID" value="BLA24_31010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15557">
        <property type="protein sequence ID" value="PPT15557"/>
        <property type="gene ID" value="CYQ11_24110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="319" mass="34074" checksum="19F06896182C0198" modified="2018-01-31" version="1">MTASPPAASPVTWAYHDGGWTDVAAASVPVGSLAMRYALSVFEGVRMYRQHGAGGVVPFLLDAHVRRLGDSLTLTRIPDPGIARLPSLVGELARRNGFDDDVYVRVAVSAHNQGTMGADVVPVLTVTGTPMGRKRWLAGGFTGMRLQISGWQRGGPNTFPPAAKNISNYAGPRLALLAAKDGGYDNCVLLNEHGRLCEAPTAALFVVRDGELHTPALSEGVLPGITRQWVLDTARRVGVPAREGLLSRGDAYLADEAFLCGTGLEIAPVRSFDDHPCRHWPDAPVTRAFTKHFFDQVRGLDSPADPLEDVPHEASGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9T1</accession>
    <name>A0A2G1X9T1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Proline-specific permease ProY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">proY</name>
        <name evidence="10" type="ORF">BLA24_30995</name>
        <name evidence="11" type="ORF">CYQ11_24095</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47929">
        <property type="protein sequence ID" value="PHQ47929"/>
        <property type="gene ID" value="BLA24_30995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15554">
        <property type="protein sequence ID" value="PPT15554"/>
        <property type="gene ID" value="CYQ11_24095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="23"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ47929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PPT15554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="480" mass="50627" checksum="B9F1222EFFE81893" modified="2018-01-31" version="1">MTPPETAPTEGGYKRSLGTRQTQMIAIGGTIGTGLFLGAGTAISQAGPSLILWYAVAGAVLFLVVRALGELLMYRPASGSFADYAREFLGPFWGYATAWTYWIMWVTTGMAEITAAGTFVRYWAPDFAQWKTALIALVVLTCANLISVKIFGELEFWFAMIKVTAILGMILIGVGVLILGFGDAGDTASVSHLWADGGIAPHGVGDSLMTLQIVLFAYLGVELVGVTAGETKDPEKNIPRAINSLPLRFALFYLGALVVILSVVSWSEFRPGTSPFVAAFAKIGIPAAAGIVNFVVLTSALSSCNAGGLYATARMLRTVGLNGDGPKALARLTGRGVPRTAVAVSAVVMAAGVGINALDPEHAFTYITSVSTGGAILVWSIILVTHMRYRRAATAGQVPASPYRMPGAPYTNWLALASFAFVTVLIGWERETRVALYVMGVWVALLAVGWAALRGRGKVAGGAATRPAPVVKPEERTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAB1</accession>
    <name>A0A2G1XAB1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32665</name>
        <name evidence="3" type="ORF">CYQ11_25715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48177">
        <property type="protein sequence ID" value="PHQ48177"/>
        <property type="gene ID" value="BLA24_32665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15803">
        <property type="protein sequence ID" value="PPT15803"/>
        <property type="gene ID" value="CYQ11_25715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="117" mass="12436" checksum="5AEE7D8F157A87EB" modified="2018-01-31" version="1">MNILGTSLRVCVDDLDASIAVYERLTGQEAVRFQRGGVKVAAVGCFFLMSGPEAELSILRRIAATVAVTDVDEALADLQAVGADIIAGPVPTPIGRNLVARHPDGSVFEYVDRRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAC4</accession>
    <name>A0A2G1XAC4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Iron-dicitrate transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fecE</name>
        <name evidence="5" type="ORF">BLA24_32595</name>
        <name evidence="6" type="ORF">CYQ11_25645</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48165">
        <property type="protein sequence ID" value="PHQ48165"/>
        <property type="gene ID" value="BLA24_32595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15791">
        <property type="protein sequence ID" value="PPT15791"/>
        <property type="gene ID" value="CYQ11_25645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="29018" checksum="88F33C08A4CEEDFD" modified="2018-01-31" version="1">MRLVVEQLTAGYPGHPVVRGVDLTVPEGQVVAVVGPNGCGKSTLLRSLARLHQPDSGTVRIGDADIWALAPRKAAHRIALLPQSPQAPEAVTVAGLVRYGRHPHQGLFRQWSREDERAVREALDATGTTALASRRLDQLSGGQRQRCWLAMVLAQETPVVLLDEPTSALDLGHAVDVLELVREVAAAGRTVVMVLHDLASAARYADVIVAMRDGRIIGHGPSREVVDAALVRELYGIEADVLAAPGDGSPVVVPAARTATACAGAGAGARSVPAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAD5</accession>
    <name>A0A2G1XAD5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xth</name>
        <name evidence="4" type="ORF">BLA24_32375</name>
        <name evidence="5" type="ORF">CYQ11_25425</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48129">
        <property type="protein sequence ID" value="PHQ48129"/>
        <property type="gene ID" value="BLA24_32375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15755">
        <property type="protein sequence ID" value="PPT15755"/>
        <property type="gene ID" value="CYQ11_25425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="259" mass="28480" checksum="7B311A8F256CCE30" modified="2018-01-31" version="1">MRIATWNVNSITARLPRLLAWLESSGTDVLCIQETKCGEDAFPFEELRALGYEAAVNADGRWNGVAVISRVGLADVVKGLPGGPDYDGSQEPRAVSATCGPVRVWSVYVPNGREVGHDHYAYKLHWLESLRDAVAVDAAGERPFAVLGDFNVAPTDEDVYDPSVFEGATHVTPAERAALGALRDAGLSDVVPRPLKYDRPYTYWDYRQLCFPKNRGMRIDLVYGNAPFAKARQDAYVDREERKGKGASDHAPVVVDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAE9</accession>
    <name>A0A2G1XAE9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32795</name>
        <name evidence="3" type="ORF">CYQ11_25845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48200">
        <property type="protein sequence ID" value="PHQ48200"/>
        <property type="gene ID" value="BLA24_32795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15826">
        <property type="protein sequence ID" value="PPT15826"/>
        <property type="gene ID" value="CYQ11_25845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="310" mass="31791" checksum="DEA31CAEC9D5975C" modified="2018-01-31" version="1">MRRVRYYENGGPEVLKVEEAEVPEPGPGELLLRTEAVGVTLPVVRKVREGGLALPASVGGEVAGKVVALGPGVTGFAVGERVTGLCFGDGYADCSLLHSSMASLVPGGASAVDAVALVRSGIVALGAYEAARPAEGESVLVTGAASGVGHLAVQLAKARGAGRVVAAVGSMEKAEFVRSLGADEVVTYGDDCWGEPVDVVLDAVGGELLSPALAALAPGGRLVAYSSGGGTLQAYDLLVGGKSAIGFQVALIARHKPALMERWRRELWELFAAGRLRPRVHAELPLENAAKAHAIIEARANLGKVVLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAW4</accession>
    <name>A0A2G1XAW4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Magnesium and cobalt transport protein CorA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_31990</name>
        <name evidence="9" type="ORF">CYQ11_25045</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48355">
        <property type="protein sequence ID" value="PHQ48355"/>
        <property type="gene ID" value="BLA24_31990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16781">
        <property type="protein sequence ID" value="PPT16781"/>
        <property type="gene ID" value="CYQ11_25045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ48355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT16781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="40389" checksum="7D865338245B2EA6" modified="2018-01-31" version="1">MNGRAVTPATPPAAPGTPPAAPDRDEGSVVHAAVYRDGHRVATPGSLADTYRLLRDQPDSMAWIGLHRPSEEELLSLADEFDLHQLAVEDALEAHQRPKLERYGDTLFVVLRAARYLDAPEEVDFGELHVFVGPDFVITVRHGAAPDLSAVRRRMEGNPELLALGPEAVLYAILDAVVDDYAPVVAGVQNDVDEIETEVFGGDPAVSRRIYELAREMVEFQRATRPLTGMLHGLMAGFTKYGTDDELQSYLRDVADHVTHISERVDGIRSALTDILQVNATLVTQQQNAEMRALAEAGFEQNEEIKKISSWAAILFAPTLVGTIYGMNFEAMPELKWAFGYPFAILLMAVVCVSLYFIFKKRDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB00</accession>
    <accession>A0A346M2I5</accession>
    <name>A0A2G1XB00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BcmB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Isopenicillin N synthase family oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bcmB</name>
        <name evidence="6" type="ORF">BLA24_33495</name>
        <name evidence="7" type="ORF">CYQ11_26545</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <title>Biosynthesis of biocyclomycin.</title>
            <authorList>
                <person name="Meng S."/>
                <person name="Pan H.-X."/>
                <person name="Tang G.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="MG018995">
        <property type="protein sequence ID" value="AXQ04973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G1XB00"/>
    <dbReference type="EnsemblBacteria" id="PHQ48395">
        <property type="protein sequence ID" value="PHQ48395"/>
        <property type="gene ID" value="BLA24_33495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16817">
        <property type="protein sequence ID" value="PPT16817"/>
        <property type="gene ID" value="CYQ11_26545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="178"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AXQ04973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT16817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="325" mass="36144" checksum="D113449B6246EF62" modified="2018-01-31" version="1">MSRAPGNTAAPEIRRGRIYRDLYEKRASGPAVQGDAHLERARIQGDRLEFAGSRARETALADGVFLLEIPADIDVAAGDAFSRQFHLGPDSPPYGRFRDLGSEHFGDPLLGFHQRVNQIEQFLLERRFWASDYPPEIARLGEQLTRLSQKVLCAVLSHVGVPERDRRRATGGCSRAAGSYHLTFNHYRPEHRDVGLSSHKDDGFLTILRTTTPGLEVNRKDRWERVPVDPDCFVINFGLSMEILTAPTKAPVAAIMHRVARQGGDRSSFGHFSSSGCAPGMDEGVFRYLPGSGLDRVCGSRELIDENDHEIYAGTDAPGDKRREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBE8</accession>
    <name>A0A2G1XBE8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48577">
        <property type="protein sequence ID" value="PHQ48577"/>
        <property type="gene ID" value="BLA24_28930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="279" mass="30264" checksum="D683C8338F5294CF" modified="2018-01-31" version="1">MKRLPIPEEVTGDEIDKDVRQELMSLPKTLAEDVARNLVMVAKLLDEEPEQAYEYSRIALRLASRVAAVREAAGFAAYATGKYSEALAEFRAARRMTGSVELWPVMADCERGMGRPERALAMAGEPEVHKLDKAGQVEMRLVAAGARKDMGQAEAAVVTLQSPELASNSIQPWTARLRYAYADALLEVGRESEAREWFAKALEADQGGTTNASDRLAELDGVEFTDALEEETEDEAEIAEPKAEDAEVKDEPKGETESAASADADADAEPKAGEGDSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBF3</accession>
    <name>A0A2G1XBF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_29220</name>
        <name evidence="5" type="ORF">CYQ11_06255</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48587">
        <property type="protein sequence ID" value="PHQ48587"/>
        <property type="gene ID" value="BLA24_29220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16376">
        <property type="protein sequence ID" value="PPT16376"/>
        <property type="gene ID" value="CYQ11_06255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="124"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="416" mass="45200" checksum="6114B3E8632F529A" modified="2018-01-31" version="1">MRLYLLALNPTDSVTEGFLPAAARLGLSVTLLTDQPAAHRRAHERHPRGPAAGAGPLPPVDLAGCDVRDFREVIGRISALGEPGAVFTNSDHLQTQAALAADYFGLPGKDWRAALRTKNKAQLRRSLARAGLDAVRSAELLPGEDPAALTAGRPPRLRATDFPCVVKPREGVASEDVVLVGDAAELAARVREIRARRPGEALVVEEYLEGPLHTLETLGDGDTLHVLASFETELCPPPHFVEERMRLLPAPPAPHTRQVLAMLRALGVGFGACHTEYAAQGERARIIEVNYRAVGDQCDLALAEALGVPLFAHILRTHLGEPLPADLGARRDGRVRMEYVCAERGGILKTAPGASDTEHDGVHLVYRPLRELGEEHPRHRTNRDYLGVVRATGTDQDRIDRAVADFLACRRWEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBV3</accession>
    <name>A0A2G1XBV3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">BLA24_28780</name>
        <name evidence="5" type="ORF">CYQ11_06685</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48702">
        <property type="protein sequence ID" value="PHQ48702"/>
        <property type="gene ID" value="BLA24_28780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12617">
        <property type="protein sequence ID" value="PPT12617"/>
        <property type="gene ID" value="CYQ11_06685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT12617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="234" mass="24613" checksum="2857E4C6E2A6ABC5" modified="2018-01-31" version="1">MSRSVLVTGGNRGIGLAIARAFAAAGDKVAITYRSGEPPEGFLAVKCDITDPEQVERAYKEIEEKQGAVEVLVANAGVTRDMLLLRMSEEDFASVVETNLTGTFRVVKRASKGMLRARKGRIVLISSVVGLRGSAGQANYAASKAGLVGFARSVARELGSRNITVNVVAPGFVDTDMTRALTDEQRAGIVDLVPLGRYAQAEEIAASVRFLASEDAAYITGAVIPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC15</accession>
    <name>A0A2G1XC15_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_27190</name>
        <name evidence="8" type="ORF">CYQ11_18465</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48766">
        <property type="protein sequence ID" value="PHQ48766"/>
        <property type="gene ID" value="BLA24_27190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14586">
        <property type="protein sequence ID" value="PPT14586"/>
        <property type="gene ID" value="CYQ11_18465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ48766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT14586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="413" mass="40910" checksum="47FD266C87FC878D" modified="2018-01-31" version="1">MSTASVVPTTSVTAAPVTPAGPAARRQVPVGWLAVLAAPIAMGANAPVLIMGDLARSLGVAQTTATWLVTSFAWAMTVGTPLFAALLRQRGARPVLLTGSALVAAGTLLVTLAPWLPLALVGRAGQALGGAGLVAVAMNLAGSARRMGVITAGFGMLGASGPLLGSLLAGAVSGRLALALSAVALFAVPAVWRRAEGTSTAPGAAFDPRGASLVVALVSALVLLPTVPLAAAGAAVVVAALLAVHVRRRPEGFVPAALLRSRTFLTSALFACTVSTSYFALLFSLPRLIARRTDWSTGAVGTGQLLALLAGAALSWLLAAASGRLGHRRVLALLAALGALAPLTAALADRAPLLLLAATVAVFVSTSGNAVLSVRVAKAAPAGQSPTAIGLFVLCYQLGGALGPALAATLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC84</accession>
    <name>A0A2G1XC84_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_27560</name>
        <name evidence="7" type="ORF">CYQ11_18085</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48828">
        <property type="protein sequence ID" value="PHQ48828"/>
        <property type="gene ID" value="BLA24_27560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14526">
        <property type="protein sequence ID" value="PPT14526"/>
        <property type="gene ID" value="CYQ11_18085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="679"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="721"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="763"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="805"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="847"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="889"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ48828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1301" mass="138501" checksum="D38641491A9D024E" modified="2018-01-31" version="1">MEDRRRDVDGATVGAPPSGTDPAGEQLRRLRRERGVSLVKLARSAFYSKGYLSKVENGEKPLTLELARACDQALETGGALERIVLHPTAGGERPRRREDDEACPYQGLSPFEQEDARWYFGREETVAHLASRLAQHLHRPGPLVLTAPSGAGKSSLLRAGLITALRRGVLPVDGSRNWPVSLFTPGEQPVAALLEQLAATTGASRRALEKSLQRGPGELAAMVRAEVTERFARAPEPETEHTGPAETPAAAPRTAAVVVIVDQFEEVFTLCQDAAERSSFIETLTALTEPPAPEDDGLPTAVVVLGMRADFYDRCLAFPGLASSLQDGHVALGPLSDAALREVIVGPARAAGLTVGPGLVEVLCRDLGRAPTGEAAGNPSRTSVLPFLSHALLGTWQHREGTALTVAGYQRTGGICEAVAATAEQAYVSLPAELRPIARRVLLQLVRIGEDHEASRRAARSNLLEGGTTREAVEAVLGVFIQARMLTADTDHVGLAHEVLLHAWPRLRQWIDEDRADLHAHQLLAEAAALWDQSGRDPSMLYRGNRLSAARDRQGDPGPAIALPAVVRRFLEASAELEATEERRDRDRVKRLRLLVSGLATLLVLTLVAGTSAFVEKRSAEEQRRMAASRELSARADLLNRDAPEAATLSALSAYRQAHTGQARGSIISAYARYRANEFTGHDKPVNAVAYSPDGRTLATASDDHTVKLWNVTSKRLITTLRGHTRGVDALAFSPDGKVLASGGEDGSAKLWHLPTNTVIATLAGHRGAVLTVVFSRDGGTLVTAGHDRDVKLWDTVTHQLTATLSGHTQQVMGAAFSADGRTLATVCNDHTVKLWDTATRKETGTLTGHSDSVMAVAFSADDRILATASADRTTMLWETATNRPLAVLTGHTDQVMDLAFSPTDRRLATASYDGTVRLWDPATGESTTTLRIGQPVQALAFSPDGRHLATALLSSRGSLPPTAGGQAGRADGTRIWDVSSGQAVATFPNGTTPPTSAVVSPDGRTLAVGDTDGLVTLWNLADDQPIVTLTGHSAAVTQLAFAPDGRTLASGSADRTVRQWNLSTFAEDAVFTGHGQAVLGVAFSPDGQLLAAAGADHTTRLWDTRSRRLVDTIIGDTDSAATVAFSPDGRTLASGNYNGSVRLWDVPARRTTTVLRGQNATTWAVAFSHDGRLLATAGADGDIRLWDAATHRPVTTLTGHTGEVRALAFSPDGRTLASGGADRTVRLWDTTGRRTEATLTGHEGDVTSVAFAPDGHTLATTSADRTVRLWELDADAVATRICQISATHQWPAKGCPGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCI4</accession>
    <name>A0A2G1XCI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28045</name>
        <name evidence="3" type="ORF">CYQ11_17595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48911">
        <property type="protein sequence ID" value="PHQ48911"/>
        <property type="gene ID" value="BLA24_28045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14440">
        <property type="protein sequence ID" value="PPT14440"/>
        <property type="gene ID" value="CYQ11_17595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="274" mass="30125" checksum="755FFDE78777F2DD" modified="2018-01-31" version="1">MGGHGQEKVGWEFFGSELKRKREAAGLTQQALGNRVFCSGSYIGQLETAVRKPQLDLAQRIDAELGTDGFFERMCRKLIDSTTNVPYFAPVAHLEGTATEIHVYSPMYVPGLLQTADYARAVFKGGFPLAPDEDIESWVASRLERRSIVAQPTKPLLWNVIDENVIRRPTGGAAVMREQLEYLASLARDERIVLQVLPYSSGAPALSGMLKLMMFDDAPPVAYSEGAMSGSFMDEPARVARLQLAYDFARAAALPRDASLTLIESAAEEYADDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCL7</accession>
    <name>A0A2G1XCL7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_27625</name>
        <name evidence="4" type="ORF">CYQ11_18015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48935">
        <property type="protein sequence ID" value="PHQ48935"/>
        <property type="gene ID" value="BLA24_27625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16634">
        <property type="protein sequence ID" value="PPT16634"/>
        <property type="gene ID" value="CYQ11_18015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="87" mass="9357" checksum="78689B94F0160FC6" modified="2018-01-31" version="1">MTPSGCSSRTRPSVDATTVPRPLLKVSTKTPLVQGARLPGERDLAEEYGVAIGTARRAIQELRERGLLITLPAKGTFVAQRQPTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCM8</accession>
    <name>A0A2G1XCM8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PQQ_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_22970</name>
        <name evidence="5" type="ORF">CYQ11_23105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48970">
        <property type="protein sequence ID" value="PHQ48970"/>
        <property type="gene ID" value="BLA24_22970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15385">
        <property type="protein sequence ID" value="PPT15385"/>
        <property type="gene ID" value="CYQ11_23105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="3">
        <location>
            <begin position="393"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="489" mass="52667" checksum="9BD08DB1BC8AAB54" modified="2018-01-31" version="1">MSQPSPRPPHGAPRPPQVWDTSFHQHRTAPPGFGPAPQAFTQPAGSSGEGGDGGRRGPRRKALVIGLALLLVAGAGTGGWLLWGRDGHRPAPAKKPAARSVDAKLDWMAEVPDADKDSVTRMSRPWFVKNTVVLSTKKAVTAYDADSGKPGWTVEVPGTACKASPAASDGVAAVVYGEQEYLCDSLMVVDVEHGRVLWKKKLLNAKGLSGPHDLATLTVDRGLVTVADVGGDPLVYAAADGKQQTPKDYGCQERGTVVARARQLTVVECQLFGRQFVMNVDQKTGTEKWTWKVPDGLAVQNVISIEPAVLAMGRENDTSPTEIVSLDDKGRLKTLVAVSSGPYEVQDCYKNDWLTCRKVVVDGDTAYLATHNERVTDDGASPNAIVAVDLNTGKQRWNVPLGGTRGNRPLTMEDGKLLVYQQATRDESGKLLALDPADGSSSVYMKLPQESAERELALARFGSAYFHDGRFYLVTDQGMSDKAMMMAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCP1</accession>
    <name>A0A2G1XCP1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">BLA24_23085</name>
        <name evidence="12" type="ORF">CYQ11_22990</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48992">
        <property type="protein sequence ID" value="PHQ48992"/>
        <property type="gene ID" value="BLA24_23085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15363">
        <property type="protein sequence ID" value="PPT15363"/>
        <property type="gene ID" value="CYQ11_22990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="285"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ48992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="424" mass="44330" checksum="7868AA34E7C66757" modified="2018-01-31" version="1">MTDSLADPHLRYAAPHATDGGPRDIVILGSTGSIGTQAIDLVLRNPERFAVTALSAAGGRVDLLAEQAHRLRVRTVAVARADKAGELREALAARYGAEPLPEILAGPDAATEVARSECHTVLNGITGSIGLAPTLAALEAGRTLALANKESLIVGGPLVKAVAKPGQIIPVDSEHAALFQALLGGTRAEVRKLVVTASGGPFRGRSKAELATVTREDALAHPTWSMGPVITVNSATLVNKGLEVIEAHLLYDIPFERIEVVVHPQSYVHSMVEFTDGSTLAQATPPDMRGPIAIGLGWPDRVPDAAPAFDWSKASTWEFFPLDTDAFPSVGLARHVGALGGTAPAVFNAANEECVDAFLSGHLPFNGIVDTVAEVVAEHGTPATGTRLTLSDVLQAETWARARARELAARSAARTAQATSEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCR4</accession>
    <name>A0A2G1XCR4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_23195</name>
        <name evidence="7" type="ORF">CYQ11_22880</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49008">
        <property type="protein sequence ID" value="PHQ49008"/>
        <property type="gene ID" value="BLA24_23195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15348">
        <property type="protein sequence ID" value="PPT15348"/>
        <property type="gene ID" value="CYQ11_22880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="340" mass="35976" checksum="3FE871432E38E380" modified="2018-01-31" version="1">MSMLRLEGVTVRFGERAALDAVDLEVAEHEIVCVLGPSGSGKSTLLRVVAGLHGADAGRVFLAGEDQTGVATHRRGVGLMFQDHQLFPQRDVAGNVAFGLRMRGTGRAEAGRRVARLLDLVGLPDAQRRPVGALSGGEQQRVALARALAPEPRLLMLDEPLGQLDRSLRERLVVELRELFGRLGTTVLAVTHDQSEAFALADRVVVMRDGRIAQAGTPLEVWQRPASEFVARFLGFDNVVAATVRGDAADTVWGTLPVPAGTAQGECRLLVRPAGVRLVPVAEGLACEVTARTFRGDHVVVRLRPADGPGIEAACPLGGAPEAGDRVGAAFVADEVVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCR6</accession>
    <name>A0A2G1XCR6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">BLA24_23440</name>
        <name evidence="9" type="ORF">CYQ11_22630</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49047">
        <property type="protein sequence ID" value="PHQ49047"/>
        <property type="gene ID" value="BLA24_23440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15307">
        <property type="protein sequence ID" value="PPT15307"/>
        <property type="gene ID" value="CYQ11_22630"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="173" mass="19062" checksum="6F1C4BE01FA024CB" modified="2018-01-31" version="1">MNGPESEEPPLRRAVCPGSFDPVTNGHLDIIARASRLYDVVHVAVMVNKAKQGLFTVDERIELLREVTAEYGNVQVEAFHGLLVDFCKQREIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFVPTNPTYSFLSSSLVKEVAAWGGDVSHLVPPQVLQALDERLARRPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCR7</accession>
    <name>A0A2G1XCR7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4439 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23050</name>
        <name evidence="3" type="ORF">CYQ11_23025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48985">
        <property type="protein sequence ID" value="PHQ48985"/>
        <property type="gene ID" value="BLA24_23050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15370">
        <property type="protein sequence ID" value="PPT15370"/>
        <property type="gene ID" value="CYQ11_23025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029447">
        <property type="entry name" value="DUF4439"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14530">
        <property type="entry name" value="DUF4439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4439" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="151" mass="15626" checksum="8E8912A6D796A273" modified="2018-01-31" version="1">MTATTRTPASRAGRETLAAAQAALAAEHATVYGYGVVGGRVDDARAAEAREAYDAHRARRDAMSRAVRDLGAEPEAAAPAYALPFPVPDQAAAVRLAVELESRLAAVYADLVRAATGGLRGEAAAGLREAAVRAVRWRGGSVAFPGLTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCS5</accession>
    <name>A0A2G1XCS5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ORF">BLA24_23285</name>
        <name evidence="9" type="ORF">CYQ11_22790</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49022">
        <property type="protein sequence ID" value="PHQ49022"/>
        <property type="gene ID" value="BLA24_23285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15332">
        <property type="protein sequence ID" value="PPT15332"/>
        <property type="gene ID" value="CYQ11_22790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="96"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ49022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="358" mass="37613" checksum="690B0667D8A7F72A" modified="2018-01-31" version="1">MAVGARSGHGEPEKRPGTAEEPHRRAPAGAAPEGARSHATYGPAGPESDGGTVTTPGDDPAGPGGTAGRDPGHRDGPGDGAPGGRKDEKKHRSFWKELPLLIGIALLLALLIKTFLVQAFSIPSESMQNTLQRGDRVLVDKLTPWFGSRPERGEVVVFHDPGGWLGESPSAETGPVAEGFQKVLSFIGLMPSAEEKDLIKRVIAVGGDTVECKGDNDPVVVNGKALKEPYVYPGNTPCGDKPFGPITVPKGRIWVMGDHRQDSLDSRWHQELAYQGTVSEDDVVGRAIVVAWPLNRWATLPVPDTFDQPGLAAAAAAAPAALGLAGAVPLVLWRRRRALGQDAPAASAGRPEQAAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCT2</accession>
    <name>A0A2G1XCT2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_23435</name>
        <name evidence="4" type="ORF">CYQ11_22635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49046">
        <property type="protein sequence ID" value="PHQ49046"/>
        <property type="gene ID" value="BLA24_23435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15308">
        <property type="protein sequence ID" value="PPT15308"/>
        <property type="gene ID" value="CYQ11_22635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="372" mass="39769" checksum="31BEEF43A8BAAF9F" modified="2018-01-31" version="1">MDVQKKLDEIVTTVAGARSMPMSASCVINRAELLALLEEVRAALPGSLAQAREVIGDREALVADAREEAERILASARAQRGSLISGTEVARQSREEADRILAEARREAAEIRAEADDYVDSKLANFEVVLTKTLGSVGRGREKLLGLPGADAPDPEGLAADAPERSLDPRLQRDSADAYVDAKLGAVSAVLAKTLEAVGKGREKLLGARPADELGALADQDGPLGRTSDADFLAELAASQEPVATVPQPAQQPAWEDYAAPAADYGAHDPYGYAQQPQQHYPPQADPYAVHSGYAQHDPYAWQTPAGGQGGQGYDTGYAQDPRHQQAQQQAQQVHEPRHGQGGGTSAALDETSFFDTGMIDLDQLRRYEQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCV0</accession>
    <name>A0A2G1XCV0_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">BLA24_23330</name>
        <name evidence="10" type="ORF">CYQ11_22745</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49031">
        <property type="protein sequence ID" value="PHQ49031"/>
        <property type="gene ID" value="BLA24_23330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15323">
        <property type="protein sequence ID" value="PPT15323"/>
        <property type="gene ID" value="CYQ11_22745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="34"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="471" mass="52349" checksum="9181814FBAB2422B" modified="2018-01-31" version="1">MAKAPILTPQAEDFPRWYQDLINKAELADNGPVRGTMVIRPYGYGLWERMQQEMDARIKDAGASNAYFPLFIPQSYLTREAEHVEGFAPELAVVTHGGGKELEEPVVVRPTSETIINEYFSKWVQSYRDLPLLINQWANVVRWEMRPRVFLRTSEFLWQEGHTAHATYEDARDYAARIHRDVYYDFMVNVLGIDVVLGRKTPKERFAGAINTLTLEGMMGDGKALQMGTSHELGQNFAKAFNTSYLSKDGHQEMVWQTSWGVSTRMVGGLIMSHGDDKGLRVPPRLASVQAVVLAIKGDDAVLAKVREIGDQLKAAGIRVQVDDRTDTPFGRRAVDWELKGVPVRIEIGPRDLENGTAMLARRIPGGKEPVRIEELAALLPKVLEEDQALLLSQSRERRESRTTDVKTIEEAAEAAVAGGWARIPWATLGVEGEAKLAEQAVTVRCLVGEDGSVPETDDAPGALAIVARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCX7</accession>
    <name>A0A2G1XCX7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ORF">BLA24_23780</name>
        <name evidence="10" type="ORF">CYQ11_22290</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49104">
        <property type="protein sequence ID" value="PHQ49104"/>
        <property type="gene ID" value="BLA24_23780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15249">
        <property type="protein sequence ID" value="PPT15249"/>
        <property type="gene ID" value="CYQ11_22290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="497" mass="52396" checksum="8B7EE7E6A4301488" modified="2018-01-31" version="1">MTEIIKLTAAEIAEKVASGELTAVEVTEAHLARIEAVDEKVHAFLHVDREGALAQAREVDAKRERGEKLGPLAGVPLALKDIFTTKGIPTTVGSKILEGWIPPYDATLTKRLKDADVVILGKTNMDEFAMGSSTENSAFGPTGNPWDLTKIPGGSGGGSSAALASYEAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGAVSRYGMVAFSSSLDQGGPCARTVLDAALLHEVIAGHDPLDSTSIDAPVPPVVEAARNGDVKGMRVGVVKQFRGEGYQPGVLQRFDESVELLKELGAEVVEVDCPSFDLALAAYYLIAPSECSSNLARFDAMRYGLRVGDDGTRSAEDVTALTREAGFGPEVKRRVMLGTYALSSGYYDAYYGSAQKVRTLITRDFEKAFEQVDVLVSPTTPTTAFAIGERADDPMAMYLADLCTIPTNLAGNAAMSLPCGLAPEDGLPVGLQIIAPAMADDRLYRVGAAVEAAFTARWGHPLLEEAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ1</accession>
    <name>A0A2G1XCZ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_01575</name>
        <name evidence="4" type="ORF">BLA24_01610</name>
        <name evidence="2" type="ORF">BLA24_23930</name>
        <name evidence="5" type="ORF">CYQ11_22140</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000027">
        <property type="protein sequence ID" value="PHQ53374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000027">
        <property type="protein sequence ID" value="PHQ53378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49127">
        <property type="protein sequence ID" value="PHQ49127"/>
        <property type="gene ID" value="BLA24_23930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53374">
        <property type="protein sequence ID" value="PHQ53374"/>
        <property type="gene ID" value="BLA24_01575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53378">
        <property type="protein sequence ID" value="PHQ53378"/>
        <property type="gene ID" value="BLA24_01610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15224">
        <property type="protein sequence ID" value="PPT15224"/>
        <property type="gene ID" value="CYQ11_22140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="70" mass="7718" checksum="C57350436986C898" modified="2018-01-31" version="1">MASIEEARTAFDRFDIDGDGFITAAEYKSVMAQLGDHQVTETVAQAIINKKDGNGDGVLSFEEFWASMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD06</accession>
    <name>A0A2G1XD06_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23535</name>
        <name evidence="3" type="ORF">CYQ11_22535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49065">
        <property type="protein sequence ID" value="PHQ49065"/>
        <property type="gene ID" value="BLA24_23535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15289">
        <property type="protein sequence ID" value="PPT15289"/>
        <property type="gene ID" value="CYQ11_22535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="318" mass="33959" checksum="B6B65876D42A9DC9" modified="2018-01-31" version="1">MPVAETGFLHHACLYGSDAEFLAMAVPFVRDGLAAGEPVLAATTPANIELLQGALGERAHALDVAETAHFGRRPVERVSAFLRYHDRRARPGRRMRMIAEPVWWGRTARQVAEWKRMESGLNVLLAALPVWMICPYDTRWVPADVARAACATHPARLDGRRLIPCAAYADPGAYAAGVAPPRAVAPPGAARTGPAGRVGPLRRFARERARAAGLTGERLALAELAVSEAAGYLLAGTGERGVSARAWEEPGALAFELLRAAPGTPPVPVFAGFRPPGPLACPEDGLWLARTLSESLEVRERAGLTRLTLRLAGPGVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD28</accession>
    <name>A0A2G1XD28_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_01615</name>
        <name evidence="3" type="ORF">BLA24_23935</name>
        <name evidence="5" type="ORF">CYQ11_22135</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000027">
        <property type="protein sequence ID" value="PHQ53379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49128">
        <property type="protein sequence ID" value="PHQ49128"/>
        <property type="gene ID" value="BLA24_23935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53379">
        <property type="protein sequence ID" value="PHQ53379"/>
        <property type="gene ID" value="BLA24_01615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15223">
        <property type="protein sequence ID" value="PPT15223"/>
        <property type="gene ID" value="CYQ11_22135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ53379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="19893" checksum="16FA2A17C0DBBF19" modified="2018-01-31" version="1">MDRASPTRRPPMSQPAYPPTHWIPANSANYTPSARPEAHPVGFLVIHVTEETFQDARRIFQDPTSKVSAHYMVASKDGYIGQFVREKDIAWHAGNWDYNTRSVGIEHEGWTDRPEYFTDALYRSSARLARAVCDRYGIPPTRAHIIGHNEVPGATHTDPGPHWDWDRYIRLVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD65</accession>
    <name>A0A2G1XD65_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23750</name>
        <name evidence="3" type="ORF">CYQ11_22325</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49099">
        <property type="protein sequence ID" value="PHQ49099"/>
        <property type="gene ID" value="BLA24_23750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15255">
        <property type="protein sequence ID" value="PPT15255"/>
        <property type="gene ID" value="CYQ11_22325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="336" mass="35794" checksum="D2E9E959C0CC92AD" modified="2018-01-31" version="1">MERRTIGAAALEVGAIGLGCMPMHWAYTASQQSGEGALRTVHAALDAGASLLDTADMYGPFTNELLVGRVLRERRAEAFVSTKCGLLVGEQHVVANGRPGYVKRACDASLRRLQTDVIDLYQLHRPDPEVPVEETWGAMAELVSAGKVRALGWCAIGARAQRRFGSSAGAAAGMYDTTIRQLERVQQVFPVSCVQAELSVWSREALDRLVPWCASRGVGLLAAMPLGNGFLSGTLTPGQGFEPEDVRARHPRFTAEMMAANQPIVAGLRRVARRHDATAAQVALAWVLAQGRHVVPVPGTKKAAWAVENAAAAGLRLGAGDLAEIAALPKAMGSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDL1</accession>
    <name>A0A2G1XDL1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24820</name>
        <name evidence="3" type="ORF">CYQ11_21250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49285">
        <property type="protein sequence ID" value="PHQ49285"/>
        <property type="gene ID" value="BLA24_24820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15064">
        <property type="protein sequence ID" value="PPT15064"/>
        <property type="gene ID" value="CYQ11_21250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="322" mass="34614" checksum="E6C7A4209D14C005" modified="2018-01-31" version="1">MRALLVVNPSATTTSARTRDVLAHALASDLKLDVATTEYRGHARDLARRAAESGNIELVVALGGDGTVNEVVNGLLHGGPDPEGLPRLAVVPGGSTNVFARALGLPNDAIEATGALLDALREGSERTVGLGLASGTPGTEDEAVPARWFTFCAGYGFDAGVVGRVEQQRERGKRSTHSLYVRQVMRQFFGEPNRRHGTITLERPGEEPLENLVMSIICNTAPWTYFGNRPMYALPKASFDTALDVLGFTKLSTLTASRHATQLLTSTPERGPEGRHAVSLHDQTSFTLHSQAPLPFQMDGDHLGLRTSVTFTGVRRALRVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDP4</accession>
    <name>A0A2G1XDP4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24840</name>
        <name evidence="3" type="ORF">CYQ11_21230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49289">
        <property type="protein sequence ID" value="PHQ49289"/>
        <property type="gene ID" value="BLA24_24840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15061">
        <property type="protein sequence ID" value="PPT15061"/>
        <property type="gene ID" value="CYQ11_21230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="34200" checksum="07928911A0862F6A" modified="2018-01-31" version="1">MHRNVSAPARFFSQVPNEIIRHPRLSPDAKCLLLWQLSLPGDLDQPFYTTAQRAGIKKTAFTRAKRQLIAEGYFHDWRRQGPDGRWATEQLISNVPLTREEAAAVRDGKQPPGAADPAPGEPSRRAVGRSPEKTEGNTSHPPLPPAEEADEVDEAGQAEGEEPARGAHTERGARLLAALVRTDRRLRLGGGDVRQLAPLAGEWLLRGVTPHDLHEALTSGLPDRLRSPAGILRDRLTRKMPEPPAHGPAPEGVPRPRPLRACAGRCGRVIRPLGDETHCRDCRTQGAVDREGGAVAATRRGVAAVQAAMLGAACLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDV5</accession>
    <name>A0A2G1XDV5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_25525</name>
        <name evidence="3" type="ORF">CYQ11_20550</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49408">
        <property type="protein sequence ID" value="PHQ49408"/>
        <property type="gene ID" value="BLA24_25525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14942">
        <property type="protein sequence ID" value="PPT14942"/>
        <property type="gene ID" value="CYQ11_20550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="86"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="545" mass="59045" checksum="417CAAE476E1A9D4" modified="2018-01-31" version="1">MLGGTRARTLGGAALALAVLGSALLATGCGGGAGGSGAGVVRASWGDPQSPLEPANTNEVQGGKVLDMIFRGLKRYDPKTGAAQDMLAEKIDSADQQNFTITVKDGWTFGNGEKVTAKSFVDAWNYAALVDNKQKNASFFQDVDGYDKVHPAKGAATAKTLSGLVVKDERTFTVRLRTKFSTWPDTLGYAAYSPLPRAFFDDHQGWLKRPVGNGPYMVDSYTKGSSMKLSRWDGYPGDDKARNSGVELRVYTDNNTAYTDLQAGNLDLVDDIPSAQLKNVKNDLGDRYINQPAGIIQTVVFPMYDEAWSKPGMEKVRRGLSMAINREQITEQIYQKTRTPATDWTSPVLGDQGGYKAGLCGGACTYDPGEAKRLIQEGGGLPGGKVTITSNVDTGSHRLWMDAVCNSINNALGNDGACTVNPVGTFADFRNQVADQRMTSLFRSGWQMDYPLVQNFLQPLYYTNASSNYGKFSDPQFDRLVDEANAESDTGKAVGTFQDAEKILAAQMPAVPLWYQNGSAGYSENLVDVQLNAFSVPVYDRIQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDX2</accession>
    <name>A0A2G1XDX2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_25510</name>
        <name evidence="7" type="ORF">CYQ11_20565</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49405">
        <property type="protein sequence ID" value="PHQ49405"/>
        <property type="gene ID" value="BLA24_25510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14945">
        <property type="protein sequence ID" value="PPT14945"/>
        <property type="gene ID" value="CYQ11_20565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="332" mass="36327" checksum="A2D54B48F99AB249" modified="2018-01-31" version="1">MTRQRTTTLLDVRDLHVEFRTRDGVAKAVNGVSYTVDAGQTLAVLGESGSGKSVTAQAVMGILDSPPGHVTAGEVLFRGEDLLTAGEERRRRLRGAKLAMIFQDALSSLNPVLTVGAQLGEMYEVHQGMTRKDARARAVQLMDRVRIPAAKDRVRDYPHQFSGGMRQRIMIAMALALEPDLIIADEPTTALDVTVQAQVMDLLAELRREYDMGLVLITHDLGVVADVADRIAVMYAGRIVETAPVHDLYAAPAHPYTRGLLDSIPRLDRKGRELYAIKGLPPSLTAIPPGCPFNPRCPMAQDVCRTDRPPLFTVGPGRASACHFWKETLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE00</accession>
    <name>A0A2G1XE00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_25790</name>
        <name evidence="2" type="ORF">CYQ11_20280</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49456">
        <property type="protein sequence ID" value="PHQ49456"/>
        <property type="gene ID" value="BLA24_25790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14894">
        <property type="protein sequence ID" value="PPT14894"/>
        <property type="gene ID" value="CYQ11_20280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="108" mass="12518" checksum="A182E3F16C521005" modified="2018-01-31" version="1">MNTEACVECGDVPELLDEDLTCGFCRISLYLKDSLMNMTVKFPVETVTHGEIEIDIDVPEEFLDEDGELRDEDGLRDWLNDNEHEWYELDPVFEEIQSKEVIEIANAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE26</accession>
    <name>A0A2G1XE26_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_25650</name>
        <name evidence="7" type="ORF">CYQ11_20420</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49429">
        <property type="protein sequence ID" value="PHQ49429"/>
        <property type="gene ID" value="BLA24_25650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14921">
        <property type="protein sequence ID" value="PPT14921"/>
        <property type="gene ID" value="CYQ11_20420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758487" evidence="4">
        <location>
            <begin position="37"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="624" mass="64984" checksum="719B48808E8CA37E" modified="2018-01-31" version="1">MTRLSGGHGPGAPSRALLGALLALCAVLLPAVVAARADTPLDLDASGRITDTVGALGRRRGQVEAALDRLYTHHHVRLYVTYVRDFSGRSGRAWADATADRNGLGPHDVLLAVATHHRQYAVSADKDSGFRKAQIQKVSVTAIAPALAQHDWAGAAVGAAAGYAAVLEGSPVRTPRIRPGSSDPGGDGLVPGDHGVWMPVAGAAGAGLAGLYLCSRHTQSVRLRRSGRGRPVLTTATTEPGLARMVQPLTPLPELEAEAARNLVDTDDAVRTSAEELLFAAIQSGEAATRPFAEAVAYARGELADAFRLRQRLDDAPQEDDGFRRHALDEICSRCTSANRRLDAESEAFDRLRAPRANARAILERAEATARALAPRVDTAEAALAALAPHHAPSALAPVAGHPAEALDRLTFAATALEEARAALAARDASQTALSLRAAEAALAQARTLTLATLRHTHDLTAAAARLRDALTEAAAVPAARAVLAEVRRELARGPCDVPALLRRLDTAALPGRPARAVLAARAEVAAARDFIGTHRGAIGCRARTRLAEAERHLSLGHADRADTLARQARALAEQDVEAYGTPYAPDAPSPARALGGAVVGGIILTGLLPATFGGGATRGRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XE38</accession>
    <name>A0A2G1XE38_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_26025</name>
        <name evidence="2" type="ORF">CYQ11_20040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49497">
        <property type="protein sequence ID" value="PHQ49497"/>
        <property type="gene ID" value="BLA24_26025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14852">
        <property type="protein sequence ID" value="PPT14852"/>
        <property type="gene ID" value="CYQ11_20040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="115" mass="12794" checksum="C21C6ECB83BF1312" modified="2018-01-31" version="1">MTITLQDIEHPPQAATADWTVLAEPQVDSVCRAVARGFSRDYGLTLEYEDALQESVIIAAERAAYVRQLVAEGGAGLLHRWLSQRLRDRWLTEAKRRSGHVSYEAARTVAESGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEB3</accession>
    <name>A0A2G1XEB3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Type II secretion system F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_26315</name>
        <name evidence="10" type="ORF">CYQ11_19325</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49545">
        <property type="protein sequence ID" value="PHQ49545"/>
        <property type="gene ID" value="BLA24_26315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14735">
        <property type="protein sequence ID" value="PPT14735"/>
        <property type="gene ID" value="CYQ11_19325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045980">
        <property type="entry name" value="DUF5936"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19359">
        <property type="entry name" value="DUF5936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5936" evidence="8">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="154"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ49545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="298" mass="32479" checksum="0378B12B203C1711" modified="2018-01-31" version="1">MMLALLLALLAGASVVGLCYGVALCRSEARLPPDLALALEVGSTRTTAVGSAVDRLGMRYAPLVLRMMGDKRVARVRRRIDRAGNPGGLTVDRYAARRAVYGALGFGGALVMLLKGQLVLAVVLVAFGLFWIEVGIWAAVRERRDAIERTLPDFLDVLAVVVSAGLGFRQALDRVAERYEGPWSDELRITLRQMDMGVSRRQAFDELRKRNDSEQVAQFVTALQQGEELGTPIVDTLIEIATDMRRTDAQLARRRAARAVPKATVVITTFMVPGTMILLIAGFFLGSGMDFGSLTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEI4</accession>
    <name>A0A2G1XEI4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_26715</name>
        <name evidence="3" type="ORF">CYQ11_18920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49615">
        <property type="protein sequence ID" value="PHQ49615"/>
        <property type="gene ID" value="BLA24_26715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14665">
        <property type="protein sequence ID" value="PPT14665"/>
        <property type="gene ID" value="CYQ11_18920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="190" mass="19907" checksum="54A14754D215A4D3" modified="2018-01-31" version="1">MTTSPASDCSLVFPPHPAWVRIVREVVRALLAAAKRTDLTDTAVVLSSEAVTNAVNACRAGGCDTPVTVLAEWTSLDQLLVLVHDNAPGVPESRRRSASGEDESGRGLTLIEGSADAWGFCAQGGGAGKAMWFTLGAPAPKAEPAWARDTCGECARLGAAQRRAVDSGSKQRAVAATVAMRRHVHDAHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEJ3</accession>
    <name>A0A2G1XEJ3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BLA24_26960</name>
        <name evidence="21" type="ORF">CYQ11_18675</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49657">
        <property type="protein sequence ID" value="PHQ49657"/>
        <property type="gene ID" value="BLA24_26960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14621">
        <property type="protein sequence ID" value="PPT14621"/>
        <property type="gene ID" value="CYQ11_18675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="18">
        <location>
            <begin position="7"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="19">
        <location>
            <begin position="454"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PHQ49657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PPT14621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="584" mass="64871" checksum="821A0E05D7AA53D9" modified="2018-01-31" version="1">MKIHKYDTVIVGAGGAGMRAAIESTKRSRTAVLTKLYPTRSHTGAAQGGMAAALANVEEDNWEWHTFDTIKGGDYLVDQDAAEILAKEAIDAVLDLEKMGLPFNRTPDGTIDQRRFGGHSRNHGEAPVRRSCYAADRTGHMILQTLFQNCVKEGVEFFNEFYVLDQLITEVDGVKKSAGVVAYELATGEIHVFQAKSVIYASGGTGKFFKVTSNAHTLTGDGQAACYRRGLPLEDMEFFQFHPTGIWRMGILLTEGARGEGGILRNKDGERFMEKYAPVMKDLASRDVVSRSIYTEIREGRGCGPEGDHVYLDLTHLPPEQLDAKLPDITEFARTYLGIEPYTDPIPIQPTAHYAMGGIPTNVEGEVLADNDTVVPGLYAAGEVACVSVHGANRLGTNSLLDINVFGRRAGIAAAEYAQKADFVELPENPAELVVDQVERLRNSTGTERVAELRKELQETMDANVMVFRTEQTIKTAVEKIAELRERYKNVSVQDKGKRFNTDLLEAIELGNLLDLAEVMAVSALARKESRGGHYREDYPNRDDVNFMRHTMAYREVDADGKDSIRLDYKPVVQTRYQPMERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEL0</accession>
    <name>A0A2G1XEL0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27030</name>
        <name evidence="2" type="ORF">CYQ11_18600</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49666">
        <property type="protein sequence ID" value="PHQ49666"/>
        <property type="gene ID" value="BLA24_27030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14610">
        <property type="protein sequence ID" value="PPT14610"/>
        <property type="gene ID" value="CYQ11_18600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="120" mass="12386" checksum="C71C4E4F2ABC94F2" modified="2018-01-31" version="1">MEQKEPIPRKPVKARRRLRSSTVVLGGMGVLATALTSCGSEPDKRCVDRNSYEAGRGYRVLDSKACSSKSGSGGSSGTWYYNSGNSGTYAKSGTFDKGKAVSRGGFGCSSSSSHSGSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEQ7</accession>
    <name>A0A2G1XEQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22960</name>
        <name evidence="3" type="ORF">CYQ11_23115</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49681">
        <property type="protein sequence ID" value="PHQ49681"/>
        <property type="gene ID" value="BLA24_22960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16743">
        <property type="protein sequence ID" value="PPT16743"/>
        <property type="gene ID" value="CYQ11_23115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="65" mass="7144" checksum="E461A98FBBACF77A" modified="2018-01-31" version="1">MDISGAEWLSAPGDTSEERVEIAYLPGGAVAMRSSADHDTVLRYTEAEWRAFVLGVRDGEFDIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XEQ9</accession>
    <name>A0A2G1XEQ9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminobenzoate oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_24525</name>
        <name evidence="2" type="ORF">CYQ11_21545</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49718">
        <property type="protein sequence ID" value="PHQ49718"/>
        <property type="gene ID" value="BLA24_24525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15116">
        <property type="protein sequence ID" value="PPT15116"/>
        <property type="gene ID" value="CYQ11_21545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ49718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="41785" checksum="04D49CB9EE16A66A" modified="2018-01-31" version="1">MTTHELYAHDPGSRGWEVPATGAARFGWDYDDGRERLLALYRKGKDKQWDADKRIDWDEEVDPYDPLGVPDANLPGHGSPYWDRMGALGQRELRRHFASWQFSQFLHGEQGALVCASRIVESVPDLDAKFYSATQAMDEARHVEIYSRFLHEKIGMLYPVNLSLRSLLDSTLRDSRWDMPYLGMQVLIEGLALAAFGMLRDNTSKPLPKQILAYVMQDEARHVAFGRMALRDHYRQLSAAELREREDFVIEGCHLMRDRLRGDEVLVDFGVPAAEAAALSEQSEYLRLFRKLLFSRIVPCVKDIGLWGERLQRAYVDMGVFDLGACDLDRLMAQDEELAERLDVQRFAREEAARTAEIAEVISEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF21</accession>
    <name>A0A2G1XF21_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19470</name>
        <name evidence="4" type="ORF">CYQ11_11330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49827">
        <property type="protein sequence ID" value="PHQ49827"/>
        <property type="gene ID" value="BLA24_19470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13398">
        <property type="protein sequence ID" value="PPT13398"/>
        <property type="gene ID" value="CYQ11_11330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="251" mass="26080" checksum="87C59B9198595A5A" modified="2018-01-31" version="1">MNQPAPGHEHAGPNGEHAAVGAYALGVLDEADATRFEEHLAGCPECATELDGLMGLAPLLAEAAEQTPDPAVLTARPRPELLDGLLDEVAAARRAGRTRRLCLVAAAVALIIAGPLAGAALTAEDPPGHSGASAAQQMYEDGEKHGGVDPATGVDATVSLERKPWGTHVALQLGAVKGPLTCDLVAVGKNGREQTVTTWAVPASGYGLKDSPVKWSREPLYTHGGAAFAQDDIDRFEVRTLDGRHLATVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XF77</accession>
    <name>A0A2G1XF77_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_19765</name>
        <name evidence="3" type="ORF">CYQ11_11025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49877">
        <property type="protein sequence ID" value="PHQ49877"/>
        <property type="gene ID" value="BLA24_19765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13347">
        <property type="protein sequence ID" value="PPT13347"/>
        <property type="gene ID" value="CYQ11_11025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="266" mass="28307" checksum="37EBD08DA5B71E65" modified="2018-01-31" version="1">MRLYAAVAVSGFRRHATYRVATAAGVFTNTVFGFIVAYTFVALWAERPHLGGYDRTQALTFVWVTQALLAAASLLGGGFQEELQERIRSGDIVVDLYRPADLQLWWLAAELGRAAFQLLGRGVVPLAVGALAFELALPADPLLWLVFLLSVLLGIVVGFGLRYLVALCAFWLLDGAGVNTLSGLLCIFFSGILLPLNVFPGALGEVVRVLPWATMLQVPADVLLGRHHGAGLAAALAFQAAWAVVLLGAGRAVQAVATRKVVVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFJ2</accession>
    <name>A0A2G1XFJ2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BLA24_20370</name>
        <name evidence="8" type="ORF">CYQ11_10415</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49975">
        <property type="protein sequence ID" value="PHQ49975"/>
        <property type="gene ID" value="BLA24_20370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13248">
        <property type="protein sequence ID" value="PPT13248"/>
        <property type="gene ID" value="CYQ11_10415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033758342" evidence="5">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PHQ49975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PPT13248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="7422" checksum="DF9A2C7792F04977" modified="2018-01-31" version="1">MSRIAKAAVVTAAVGATLAGVTGGAVADSGAKGAAVGSPGVISGNVIQVPIHIPINLCGNSIDIVGLLNAASGNICVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XFK0</accession>
    <name>A0A2G1XFK0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkanal monooxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_19965</name>
        <name evidence="4" type="ORF">CYQ11_10825</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ49909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49909">
        <property type="protein sequence ID" value="PHQ49909"/>
        <property type="gene ID" value="BLA24_19965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16483">
        <property type="protein sequence ID" value="PPT16483"/>
        <property type="gene ID" value="CYQ11_10825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ49909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="365" mass="38680" checksum="532213E1016F6333" modified="2018-01-31" version="1">MIRASALGSAPVPLSVLDLAPVGSGRTARQALGTTVELARLAERRGYHRLWVAEHHSMPGIASSSPAVVLAHLAAHTERIRLGSGGVMLPNHAPLVIAEQFGTLEALAPGRVDLGLGRAPGTDGATAAALRRQDRLAEGADEFPQQLSELTRFLDDDFPEGHPYGRIHAVPGPVQGRVPGGVQRADRPVVWLLGSSGFSARLAGLLGLPFSFAHHFSAAGTLPALELYRESFRPSAVLDRPYAKIGVQAFAADDAREARRQVLTGALAMLRLRTGRPGLIPSPEEAERYAFGPAEQEFVADWLRNVVFGTPDEVRAGLDALVERTGVDELMITTNAHGPAARLRSYELIADAYGLPGGGPGPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG21</accession>
    <name>A0A2G1XG21_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_21460</name>
        <name evidence="7" type="ORF">CYQ11_09325</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50151">
        <property type="protein sequence ID" value="PHQ50151"/>
        <property type="gene ID" value="BLA24_21460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13066">
        <property type="protein sequence ID" value="PPT13066"/>
        <property type="gene ID" value="CYQ11_09325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="284" mass="28432" checksum="69E49F795C277E9B" modified="2018-01-31" version="1">MCPPPLPGTTAGPCHGGSPTIAPVATDISLTTLIVLCLAAAAAGWIDAVVGGGGLLQLPALLVGLPHTAPAHILGTNKAVAICGTTAAAVAYSRKAPLDLRTAVRIGLAALGGSLAGAFFASGIDSAVLRPLIMAVLMVVLAFVLLRPAFGTTVADAAPPSRRRVLTAILVAGLGIGFYDGLIGPGTGTFLVLALAGILHMELVTASGTAKIVNVCTNVGALVTFTWQGAVLWQVAAPMAVFNLMGGALGARMALRRGSGFVRAVLVVVVVSLVCKLGYDQWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XG71</accession>
    <name>A0A2G1XG71_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_21960</name>
        <name evidence="7" type="ORF">CYQ11_08825</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50234">
        <property type="protein sequence ID" value="PHQ50234"/>
        <property type="gene ID" value="BLA24_21960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12981">
        <property type="protein sequence ID" value="PPT12981"/>
        <property type="gene ID" value="CYQ11_08825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="79" mass="8030" checksum="D7E3E4CBC9E7354B" modified="2018-01-31" version="1">MSGAPRWRVAVDRGVCVGSGLCAAVAPGAFRLDATRRSRPVAEETEASPAVLEAAEGCPVEAVALHVAGTGEAVFPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGF3</accession>
    <name>A0A2G1XGF3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_22470</name>
        <name evidence="4" type="ORF">CYQ11_08320</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50316">
        <property type="protein sequence ID" value="PHQ50316"/>
        <property type="gene ID" value="BLA24_22470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12897">
        <property type="protein sequence ID" value="PPT12897"/>
        <property type="gene ID" value="CYQ11_08320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="163"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="451" mass="49457" checksum="431CF9AAD9E36828" modified="2018-01-31" version="1">MSGLVVTLLVVFAVAGLLRWWRPTWYWLTFGATFAALRVLVRYSSVMDACRLTVPPSRWRMALARFANRPISQPRVPRLLRLRPTRTGLVLRLKLCPGQDAFDVAAATDRLRHSFVMYRVMSQEVRSGVVELRMTGYDVLKRVQMPSKVDRASMRVPVALREDGSVHYRDYRAVPHALTIGATESGKSVYLRNLVAELAKLDVALAGIDCKQGVELFPLARRFSALADNSDTAADLLDALVSRMGGVYQLIRAEQRIAADVPDAEIAADIWDLPDDLRPTPVVVVVDEVAELALVASKDEEKRRDRCVTALVRLSQLGRAAGIYLEICGQRFGSELGKGITMLRAQLTGRTAHRVNDESSANMAFGDIAPDAALAAIHIPPDRPGVAIAGDSTGGWSRIRAPHISLRQVVNVCNRYAHLTPDLPELAPFRPALPHSAKAPAPAVETAPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XGT8</accession>
    <name>A0A2G1XGT8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="11" type="ORF">BLA24_01105</name>
        <name evidence="10" type="ORF">BLA24_22675</name>
        <name evidence="12" type="ORF">CYQ11_08115</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="NHZO01000151">
        <property type="protein sequence ID" value="PHQ50349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50349">
        <property type="protein sequence ID" value="PHQ50349"/>
        <property type="gene ID" value="BLA24_22675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53558">
        <property type="protein sequence ID" value="PHQ53558"/>
        <property type="gene ID" value="BLA24_01105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12863">
        <property type="protein sequence ID" value="PPT12863"/>
        <property type="gene ID" value="CYQ11_08115"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PHQ50349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ53558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT12863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="395" mass="42965" checksum="A897AC6018061EE0" modified="2018-01-31" version="1">MRVVTTAQPLDVQPTPLALLLLGRESDPRSERGVECPGDLPAASDPDLVERARAAKAKLGDKVFVLGHHYQRDEVIEFADVTGDSFKLARDAAARPDAEYIVFCGVHFMAESADILTTGDQQVVLPDLAAGCSMADMATAEQVAECWDVLTEAGIAEVTVPVSYMNSSADIKAFTGKHGGTICTSSNAERALTWAFEQGEKVLFLPDQHLGRNTAVRDLGMSLEDCVVYNPHRPNGGLTAEELRGAKMILWRGHCSVHGRFSLDSVNDVRERIPGVNVLVHPECKHEVVAAADYVGSTEYIIKTLEAAPAGSKWAIGTELNLVRRLANRFASEGKEIVFLDKTVCFCSTMNRIDLPHLVWALESLAEGKVVNRIEVDPEVASFSKLALERMLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XH96</accession>
    <name>A0A2G1XH96_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_17515</name>
        <name evidence="3" type="ORF">CYQ11_15760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50600">
        <property type="protein sequence ID" value="PHQ50600"/>
        <property type="gene ID" value="BLA24_17515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14145">
        <property type="protein sequence ID" value="PPT14145"/>
        <property type="gene ID" value="CYQ11_15760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="260" mass="27017" checksum="106F9BA0D47FE090" modified="2018-01-31" version="1">MPHPVARAGADLRLIRAAVFTAVCVLLSAGGHVLASCASVPLWTLGAAFLLVFAVAVALAGRERSLPGIAACLAVGQLALHTLFGLAQQHPAAPRRAGAEGHLIDFAAQLTCNQPRAATADEARRVIIGAGFDPAVHPMAAGVPAGGPQPSGNVLAHLLPLSLPMLLGHLLAAVAVGWLLRRGEATLWRVLELSADSARGVAEAALVQTLGALLLFVRPQVPDRPAVSRRGAHDDERPAREPVLQHFVIRRGPPRFALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHH3</accession>
    <name>A0A2G1XHH3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="6" type="ORF">BLA24_17960</name>
        <name evidence="7" type="ORF">CYQ11_15315</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003949374.1">
        <property type="nucleotide sequence ID" value="NZ_PKFQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50680">
        <property type="protein sequence ID" value="PHQ50680"/>
        <property type="gene ID" value="BLA24_17960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14065">
        <property type="protein sequence ID" value="PPT14065"/>
        <property type="gene ID" value="CYQ11_15315"/>
    </dbReference>
    <dbReference type="GeneID" id="61439346"/>
    <dbReference type="GeneID" id="66856514"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ50680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="45" mass="5252" checksum="690F9E237D629CEF" modified="2018-01-31" version="1">MSKRTFQPNNRRRAKTHGFRLRMRTRAGRAILASRRGKGRARLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHI9</accession>
    <name>A0A2G1XHI9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="4" type="ORF">BLA24_18050</name>
        <name evidence="5" type="ORF">CYQ11_15225</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50693">
        <property type="protein sequence ID" value="PHQ50693"/>
        <property type="gene ID" value="BLA24_18050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14052">
        <property type="protein sequence ID" value="PPT14052"/>
        <property type="gene ID" value="CYQ11_15225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="84" mass="9540" checksum="18AB3F2B2F9FC8B0" modified="2018-01-31" version="1">MPKSRIRKKDDFTPPPVKQQNLKLTTGRRWVAPLMLAMFLIGLAWIVVFYVTSGDMPVESLKNWNIVVGFGFIAAGFVVSTQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHN2</accession>
    <name>A0A2G1XHN2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inositol phosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_17795</name>
        <name evidence="10" type="ORF">CYQ11_15480</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50649">
        <property type="protein sequence ID" value="PHQ50649"/>
        <property type="gene ID" value="BLA24_17795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14096">
        <property type="protein sequence ID" value="PPT14096"/>
        <property type="gene ID" value="CYQ11_15480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045977">
        <property type="entry name" value="DUF5933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19356">
        <property type="entry name" value="DUF5933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5933" evidence="8">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="154"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ50649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT14096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="435" mass="47565" checksum="6594BCF30432A22E" modified="2018-01-31" version="1">MLWAVASVVTLGFLVALEIAARHYGLPGPMTNQAKEVIFAPKSGPLLYASMALMMVVLTWRQRFVAVGVAVGIDVVFWLVRWAVDAKMMFGNGALWVILGCAVIAVTRRTGRERVLLLKGVGLALLLVAGRKTGDTWLLITSKTRPAVLDQYVATADHALGNPSWVAGRIVEATGPVGTHVLDWVYGQLAVAAVVFALYQLRDVAAERRFPGHHLVRTFLVIGLLGPAIYMIFPVVGPIFAYGTGAFGTGGEHWALAALWPHTPPPIDIPHPMPYDEITPRNCMPSLHTAWATAIFIHSRKGPRILRFTGAFWLIATLGATLGFGYHYGTDIIAGVVFTLTIEAALRAHDRGWDRSGIQLVTYGATVFTAFLVSYRYLPMEMATHPWLFGPLLVLAMASVVYGYVRTTRLWEPKAPKTAPVRQPEPEAEPQPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHU0</accession>
    <name>A0A2G1XHU0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_18700</name>
        <name evidence="4" type="ORF">CYQ11_14580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50800">
        <property type="protein sequence ID" value="PHQ50800"/>
        <property type="gene ID" value="BLA24_18700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13942">
        <property type="protein sequence ID" value="PPT13942"/>
        <property type="gene ID" value="CYQ11_14580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ50800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="256" mass="26834" checksum="0FCBBB01A8DD4D0B" modified="2018-01-31" version="1">MEHEVFVPFPVGAVRRVLSDPARVARCVPGLQQDASAGTTLTGRLRLRIGGSTITYRGALRLTERDGVYELSGEGTEARGSGTVTIALSALPEEMPGGTRLSCTGTVGGAGRLAEFDAKTAESAARRLLDRFAAALAEELREDEVRLPSLDAPAPGEPADPEDPDDMGPEDSDDSEDGLDGDALDDEPPAEAAHARRTMIGRSAEEVDHAPPRGRYAPVPAPETTSGTAVLRWAAPAAALALAGAVVVTRVLRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHY1</accession>
    <name>A0A2G1XHY1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_19055</name>
        <name evidence="5" type="ORF">CYQ11_14225</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50852">
        <property type="protein sequence ID" value="PHQ50852"/>
        <property type="gene ID" value="BLA24_19055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13889">
        <property type="protein sequence ID" value="PPT13889"/>
        <property type="gene ID" value="CYQ11_14225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="247" mass="26736" checksum="83A4358346C7DC1B" modified="2018-01-31" version="1">MHIQGSHWSAAVATTDGTGGRHTPLRVDAQRNLEHVLRAAREVFGELGYGAPMEDVARRARVGVGTVYRRFPSKDVLVRRIAEEETARLTEQARTALGQEDEPWSALSRFLRTSVASGAGRLLPPQVLRVGVDVEPEDGRDRLQARVPQQRQPVAAGQLHELRLVEQRPAAVEERDDAGAAALLDVVGRLVERARAAGELRADVTVADVLLVIATAAPSLPDAAQQAAASSRLLDILLEGLRSRPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHZ8</accession>
    <name>A0A2G1XHZ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_19080</name>
        <name evidence="2" type="ORF">CYQ11_14200</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50856">
        <property type="protein sequence ID" value="PHQ50856"/>
        <property type="gene ID" value="BLA24_19080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13885">
        <property type="protein sequence ID" value="PPT13885"/>
        <property type="gene ID" value="CYQ11_14200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ50856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT13885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="83" mass="9079" checksum="ECACEFD2AD127D8A" modified="2018-01-31" version="1">MDGVSTYLALTFGTLLSSQGTDASFVLTLSGFPPGASLRCFQPYQIRFPFRFRFGFRFRPPVGAGFFAPSGVITTLADFPRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XHZ9</accession>
    <name>A0A2G1XHZ9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="15" type="ORF">BLA24_17055</name>
        <name evidence="16" type="ORF">CYQ11_16220</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="NHZO01000148">
        <property type="protein sequence ID" value="PHQ50872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50872">
        <property type="protein sequence ID" value="PHQ50872"/>
        <property type="gene ID" value="BLA24_17055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16600">
        <property type="protein sequence ID" value="PPT16600"/>
        <property type="gene ID" value="CYQ11_16220"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="14">
        <location>
            <begin position="66"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="73"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ50872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT16600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="412" mass="42336" checksum="76E33DDB0F41C7DC" modified="2018-01-31" version="1">MAGTGGPADGHAGRRAGGHAGDRAGGHAGGRAGDPGSERADDRPGAEARTRTGLGAGARGRAAGPTLAVVGATGAVGKVMLEILSQHADIWGEIRLVASARSVGRKLTVRGELVEVVALSEDVFEGVDVAMFDVPEAVAAQWAPIAAAKGVVVVDNSAAFRMDPDVPLVVPEVNAHAARLRPRGIIANPNCTTLSMIVAVGALHAAFGLRELVVSSYQAVSGAGKEGVDALRTQLAAVVGTELGTQPGDVRRAVGDDTGPFPAPVALNVVPWAGSLKEDGWSSEELKVRDETRKILGVPDLRVSATCVRVPVITTHSLSVHARFETEVTVERAHEILANAPGVVLCDSPADGEFPTPADAVGTDPTWVGRVRRSLDDPQALELFVCGDNLRKGAALNTAQIAESVASELTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XI93</accession>
    <name>A0A2G1XI93_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorismate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnA</name>
        <name evidence="4" type="ORF">BLA24_14210</name>
        <name evidence="5" type="ORF">CYQ11_13865</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:40051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="4.2.1.151"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50947">
        <property type="protein sequence ID" value="PHQ50947"/>
        <property type="gene ID" value="BLA24_14210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13832">
        <property type="protein sequence ID" value="PPT13832"/>
        <property type="gene ID" value="CYQ11_13865"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00995">
        <property type="entry name" value="MqnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030868">
        <property type="entry name" value="MqnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37690">
        <property type="entry name" value="PTHR37690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ50947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="296" mass="32299" checksum="45E29EC89064FC01" modified="2018-01-31" version="1">MDNSASDGAIAAQAPGPLRSRPRVGHIQFLNCLPLYWGLARTGTLLDLDLTKDTPEKLSEQLIAGELDIAPVTLVEFLKNADRLVALPDIAVGCDGPVMSCVIVSQLPLEKLDGARVALGSTSRTSVRLAQLLLAERYGVQPDYYTCPPDLSLMMREADAAVLIGDAALRASLHDAPRLGLQVHDLGQMWKDWTGLPFVFAVWAARRDYAAREPRIVAKVHEAFLASRDLSLEEVGKVAEQAARWEVFDAELLERYFTTLDFRFGSAQLAGVTEFARRTGPTTGFPADVRVELLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XIE0</accession>
    <name>A0A2G1XIE0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_14400</name>
        <name evidence="3" type="ORF">CYQ11_13675</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ50980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ50980">
        <property type="protein sequence ID" value="PHQ50980"/>
        <property type="gene ID" value="BLA24_14400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13798">
        <property type="protein sequence ID" value="PPT13798"/>
        <property type="gene ID" value="CYQ11_13675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ50980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT13798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="405" mass="42663" checksum="732482D535DD15E0" modified="2018-01-31" version="1">MTLPVAVIGAGPYGLSTAAHLKACAVPTRVFGSPMVSWQEHMPAGMLLKSTPPASNIDAPQPGHTLFDFCQDVGERRFESDWDAIPVETFAQYGLWFQRRLVPGLERERVVSVERREGGGGFELKLDSGEQFAARAVVVATGLSGLARLPAELAAAVPDGPSASGPVSHSSQHSDLSVFAGKDVVVVGAGQSALESAVLLAESGAASVRVVARRKGAVRFGAAPDGQSPLKPDTPFGRAWSLYAFSYHADGFRHLPAPTRQYLVRRVLGPLGAWWLRERFVGRVLVTEGKRIVAARVESGRPVLTLSGEGDTTGTGAQSELHADHVIAATGYRVDVAAMDFLGPGLRTRLAVSAGGPRLGPGYRSSVPGLFFTGLPAAASYGPVMRFVCGTEYASPRLARAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ30</accession>
    <name>A0A2G1XJ30_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">BLA24_15900</name>
        <name evidence="5" type="ORF">CYQ11_12175</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51237">
        <property type="protein sequence ID" value="PHQ51237"/>
        <property type="gene ID" value="BLA24_15900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13539">
        <property type="protein sequence ID" value="PPT13539"/>
        <property type="gene ID" value="CYQ11_12175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ51237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT13539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="196" mass="21433" checksum="AC4A73073811167E" modified="2018-01-31" version="1">MTDESSPWLIVGLGNPGGEYAANRHNVGFMVADLLAERMRAKFKAHKARAQVVEGRLGAPGPSSRRVVVAKPMSFMNLSGGPTTALRDFYKVPVERIVVVHDELDIDYGMLRLKLGGGDNGHNGLKSITKSLGPDYCRVRFGIGRPPGRMQVADFVLKDFSSVERKELDYQVDRAADAVESLIVDGLERAQGTYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJ88</accession>
    <name>A0A2G1XJ88_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_16280</name>
        <name evidence="4" type="ORF">CYQ11_11795</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51297">
        <property type="protein sequence ID" value="PHQ51297"/>
        <property type="gene ID" value="BLA24_16280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13477">
        <property type="protein sequence ID" value="PPT13477"/>
        <property type="gene ID" value="CYQ11_11795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ51297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="267" mass="28638" checksum="4B66C7D91F0AF57E" modified="2018-01-31" version="1">MRKTVLVPVRKSYCDAHIAKDGTEVEATASLSLGSHTWDLCLEHDVVFGRYLTDALGVPAEAPATSVVTGQGDADSRGLTHAVEGHVPDSGGLTPTMSVSAQDEPENDDDPGEVEHDEPERPSVMVSGDVPGYLIDEAREAVRNCGYDVVGRADDSTVLIICGEGAERNATKLADARERDLPCMDATVPGRFKSAVRAGEFTGGDPLPEPVKVGRSGLSERERNRLVRSWARENGYKVPDKGRIPMHVRHGYELSHKTTPDGEAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJC7</accession>
    <name>A0A2G1XJC7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chemotaxis protein CheX</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Chlorinating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15435</name>
        <name evidence="2" type="ORF">CYQ11_12640</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51358">
        <property type="protein sequence ID" value="PHQ51358"/>
        <property type="gene ID" value="BLA24_15435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16518">
        <property type="protein sequence ID" value="PPT16518"/>
        <property type="gene ID" value="CYQ11_12640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010092">
        <property type="entry name" value="Chlorin_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01762">
        <property type="entry name" value="chlorin-enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="301" mass="34633" checksum="6BDE38F50DAEB967" modified="2018-01-31" version="1">MSANAVVPDDIKSDIEQFGRDGFIGPIKLYEPEEAAELIREIRINNHITDKALYKNSVNYDRHFDIPELTRHITHPTIVKYLNAILGPDVLCWRTEWFPKFPGAKATEWHQVRDYSYANGKPQLLPTASEWNAYIDITVWTCFTPATKDRACMKFVRGSQREWIFDEHKATQTGRDDFDVQHANTGFFGYDFSDFAVDPDWEPRPEDVVELEMQPGEAVIFTASCVHGSTPNLTERETRFAIAGRYVPTHVRVYPDQDSFTAHGATFDLSEYGSVLVSGENKFDHHRIRTENNHGEKFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJG0</accession>
    <name>A0A2G1XJG0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_15925</name>
        <name evidence="2" type="ORF">CYQ11_12150</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51366">
        <property type="protein sequence ID" value="PHQ51366"/>
        <property type="gene ID" value="BLA24_15925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16511">
        <property type="protein sequence ID" value="PPT16511"/>
        <property type="gene ID" value="CYQ11_12150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="226" mass="25866" checksum="9AEEAB9E17C533D3" modified="2018-01-31" version="1">MVHAKTDMRARARELRRAGRTYDEIVAELGVSKSSVSLWVRDLPKPRKTTEQLDAMREARWAPHRRAQAIKRMETKLEAANEIGPMTDRELFLVGVGLYWSEGAKSKIHRPAERATFVNSDPGMIRVYLAWLALLGVEPDRIQYRVMIHESADVGRAERFWADLASVDVTALKKTTLKKHDPRTVRKNVGDTYYGCLVVDVLRSADLYRRIEGWWYGIVVGVETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJH9</accession>
    <name>A0A2G1XJH9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_15515</name>
        <name evidence="6" type="ORF">CYQ11_12560</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000147">
        <property type="protein sequence ID" value="PHQ51360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51360">
        <property type="protein sequence ID" value="PHQ51360"/>
        <property type="gene ID" value="BLA24_15515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT13609">
        <property type="protein sequence ID" value="PPT13609"/>
        <property type="gene ID" value="CYQ11_12560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ51360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="329" mass="35763" checksum="8E2F58B12B4118F5" modified="2018-01-31" version="1">MTDTPARLLNLLSLLQTPREWPGSELAERLGVSPRTIRRDIERLRDLGYPVQATMGADGGYRLAAGAAMPPLVLDDEEAVAIAVGLRAGAGHAVEGIEEASVRALAKLEQVLPSRLRHRVSALQNATVPLTWGSGDGATVDPHTLTAMAAAATGHERLRFAYRTGDGTRTRRLVEPHQLVSTGRRWYLVAYDIDREDWRTFRVDRVSEPFATGARFAPRELPAADAAEYLSRSLSGSQPTYRVVATFSAPADFVASRLPGWLGTPTALGADSCRLDTTTSDSLEWMAFRLAIVDCEFTVHEPAELVEHLRGLGARISRAAERCPQGQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJK4</accession>
    <name>A0A2G1XJK4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_13805</name>
        <name evidence="3" type="ORF">CYQ11_01500</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000146">
        <property type="protein sequence ID" value="PHQ51406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51406">
        <property type="protein sequence ID" value="PHQ51406"/>
        <property type="gene ID" value="BLA24_13805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11746">
        <property type="protein sequence ID" value="PPT11746"/>
        <property type="gene ID" value="CYQ11_01500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="71"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="374" mass="40806" checksum="0B44C2FEE687662A" modified="2018-01-31" version="1">MAPPAGLLAPTTAATAGSRRLVCRPRPAAGPVGLDADNANEWWGRVTDTIKHRFIEVNGVRLHVAEQGEGPLVLLLHGFPESWYSWRHQFEPLARAGFRVVAPDQRGYARSEQPADPSAYSLLHLVGDVVGLVHALGEEQAVVVGHDWGAPVAWTSALLRPDVVRAVAGLSVPPVLPGGMAPPSVTRRLYGDGFYQLYFQRPGVADAELAQDPASSFRRILFSGSGDNPNVERPRPWTIPEGLSLLDTVPEPKELPGWLTEEDVQAFAEDYAGHGEHAFTGPLNWYRNIERNQELLAPFRGRGIEVPALYVYGDRDMVTSMAGMDQLIAGLDRVAPKLHRSVRLPGCGHWTQQERPAEVNAALVDFLTQLPGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XJV9</accession>
    <name>A0A2G1XJV9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_13345</name>
        <name evidence="2" type="ORF">CYQ11_01065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000145">
        <property type="protein sequence ID" value="PHQ51490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51490">
        <property type="protein sequence ID" value="PHQ51490"/>
        <property type="gene ID" value="BLA24_13345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11672">
        <property type="protein sequence ID" value="PPT11672"/>
        <property type="gene ID" value="CYQ11_01065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ51490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="216" mass="23584" checksum="6CAD24D160D012A2" modified="2018-01-31" version="1">MRLVGMRTVSGIGVVERDEEETFLSEVVPVHGAPLVLVARGNGPRTPDEMLVLASGSGQVTARIPLDGPHGDLALFPYDYGPADDRPVTAVADVLVARTRLWSISADHLTAFALDGEGIRWTWRSKGTVVGVFRHDTDVVAVSKYVAPDDAGSGPDGTVHVHLLEGSTGAVRAVRRLRGYQAGMRGRYHLDREGHLFHTSHEGHHLWSPVQMFRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK35</accession>
    <name>A0A2G1XK35_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_12965</name>
        <name evidence="3" type="ORF">CYQ11_17325</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51603">
        <property type="protein sequence ID" value="PHQ51603"/>
        <property type="gene ID" value="BLA24_12965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14396">
        <property type="protein sequence ID" value="PPT14396"/>
        <property type="gene ID" value="CYQ11_17325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="20494" checksum="59EEEED0EF06C3A0" modified="2018-01-31" version="1">MRLEDVKTTPLSPVETERPVPRWAMVTARAIPLVLLPQCLWRLPFAFHFQMGMAHDPDAAVWPVWATIPYVFGLSLLTEALALLCFGLVRGWGEVAPAWLPFIGGKRIPPAAALVPATLGGLGATAFWAPSVLVWLGLIEDDSVGYVNGGWETLARVCIAPGTLWGPMVLALTYGYYVRRCRPGKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XK76</accession>
    <name>A0A2G1XK76_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase BLA24_12835</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_12835</name>
        <name evidence="7" type="ORF">CYQ11_17190</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000143">
        <property type="protein sequence ID" value="PHQ51581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51581">
        <property type="protein sequence ID" value="PHQ51581"/>
        <property type="gene ID" value="BLA24_12835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14373">
        <property type="protein sequence ID" value="PPT14373"/>
        <property type="gene ID" value="CYQ11_17190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT14373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="414" mass="45023" checksum="7C0D436CFD73D7BB" modified="2018-01-31" version="1">MSLEIRPVGETEVPDWVRAMRTGFLVPPVAPKDEVEIRRAGMDLARTQGAFDDGRCVGTFRSFTQRLTVPGGTAVTANAVTNVTVTPTHRRRGLLGRMMGNALRAARERGDAAATLLSAEYPIYGRFGFGPASRVTRWEVQVTRAGLDPHYAGPADGGRVDFADGGTVRQLAPALHERLRARQHGAVDRTERWWRMATGDMPQLGPQAWTEPFYALYRSPAGSVDGLLTYTADAVWEAKLPMNTATVRDLIAVSPEAERALWHFLFSIDWITRVDTGLRAPDDVLPLLLPDPRAARVTTDADYMWLRPLDVPALLEARTYACPGSLVLDVTDPDGLSGGRFALEAGPDGASCVPTSRPAELSLGVGELGALCLGDESAVRLAALGRVREDRPGAAARAELMLRTARRPWCPDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKK2</accession>
    <name>A0A2G1XKK2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_11805</name>
        <name evidence="3" type="ORF">CYQ11_03045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51762">
        <property type="protein sequence ID" value="PHQ51762"/>
        <property type="gene ID" value="BLA24_11805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12010">
        <property type="protein sequence ID" value="PPT12010"/>
        <property type="gene ID" value="CYQ11_03045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05257">
        <property type="entry name" value="Arna_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045869">
        <property type="entry name" value="Arna-like_SDR_e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ51762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="333" mass="35882" checksum="CD0F473B48F218ED" modified="2018-01-31" version="1">MSAPSLVAVTGAEGFIGSHLVEALVADGHRVRAMVQYNSFSSFGWLEDLPEDVMAQVEVVLGDVRDPGSVQGLVTGAETVYHLAALIAIPYSYRAPHSYVETNVMGTLNVLEAVRHLGVPRLVHTSTSETYGTAQTVPISEDHPINTQSPYAASKAGGDRLADSYHASFELPVVTLRPFNTYGPRQSMRAVIPTVVAQVAAGERTITLGDLRPTRDFSYVKDTVAAFRAVGTAPADDVVGRTFNAGTGEEISVGDLVTLVGKLMDTDLTVREDPRRLRPAGSEVMRLVCDSSRLRAATGWAPAHTLEEGLRETVAFFRDPVNLGRYKTGTYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKL5</accession>
    <name>A0A2G1XKL5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_11565</name>
        <name evidence="10" type="ORF">CYQ11_02800</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51721">
        <property type="protein sequence ID" value="PHQ51721"/>
        <property type="gene ID" value="BLA24_11565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11969">
        <property type="protein sequence ID" value="PPT11969"/>
        <property type="gene ID" value="CYQ11_02800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ51721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT11969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="347" mass="37372" checksum="45257B190A9CC53C" modified="2018-01-31" version="1">MAAGDDRLAHPDATLGGGPSGLIGRRIAGYQVESEIGRGGMAVVYRATDLRLDRTVALKLLAPELARNDTFRQRFAHESRVAAAIDHPHIVPVFEAGEVEGVLYIAMRYVPGQDLRALLDRGGPLELPAACRIAGQVASALDAAHAHDLVHRDVKPGNILVAEGTDSDHPEHVYLTDFGLTKKSLSLTGYTRVGQFVGTLDYVAPEQISGKPVDGRCDVYSLACVVFETLVGHPPFRRDDDMALLWAHQYDPPPKLSDHVPDVVPGVDEVLVKALAKSPDDRYDGCLEFVTALRLAGRGGPPPPPEPEPTGHASTQVDMRLDDLPPEPPPPPTPPAWARPVFPELSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKV7</accession>
    <name>A0A2G1XKV7_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BLA24_01865</name>
        <name evidence="16" type="ORF">BLA24_11070</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="NHZO01000132">
        <property type="protein sequence ID" value="PHQ51894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000034">
        <property type="protein sequence ID" value="PHQ53349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51894">
        <property type="protein sequence ID" value="PHQ51894"/>
        <property type="gene ID" value="BLA24_11070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53349">
        <property type="protein sequence ID" value="PHQ53349"/>
        <property type="gene ID" value="BLA24_01865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="15">
        <location>
            <begin position="68"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PHQ51894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PHQ53349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="321" mass="34524" checksum="69B4E6CE69775C98" modified="2018-01-31" version="1">MSTSRTSASPTSAPHTSVPRTSGPPAPTPQTSTLLHSPVIDWFEVHARDLPWRRPEAGPWGVMVSEFMLQQTPVSRVLPVYEQWLSRWPRPADLAAEPPGEAVRAWGRLGYPRRALRLHAAASAITERHGGEVPDDHAKLLALPGVGEYTAAAVASFAYGQRHAVLDTNVRRVFARAMTGIQYPPNATTAAERKLARALLPQEEAVAARWAAATMELGALVCTARTPSCARCPIAAHCAWLAAGSPAHDGPPRRGQTYAGTDRQVRGKLLAVLREAVAPVPRSVLDAVWDEPVQRARALDGLVADGLVEPLAGGMYRLPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XKW5</accession>
    <name>A0A2G1XKW5_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_12310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000136">
        <property type="protein sequence ID" value="PHQ51867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ51867">
        <property type="protein sequence ID" value="PHQ51867"/>
        <property type="gene ID" value="BLA24_12310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ51867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="224" mass="23533" checksum="8E81ABFB5A3225DF" modified="2018-01-31" version="1">MLVPARLDLAALRAVGPDEEVPDLLRGLVRVPVRRAAAPAATEQPSGADLRSRLAAAHEGERRHILLDLVRATAAAVLGFADKNEVEAHRGFLELGLNSLTAVELRNRLGAAAGLTLPVTVMFDHPSAGEMAGFLGEQLLRDQRPEGSQATVHGDLDRIEASLAGGVLDEQERDAVTARLQELLAKFGDGSGGGAGRSALADQLADVSDDDLFDIIDNGLGTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLG9</accession>
    <name>A0A2G1XLG9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol oxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">GMC family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09240</name>
        <name evidence="4" type="ORF">CYQ11_27850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52098">
        <property type="protein sequence ID" value="PHQ52098"/>
        <property type="gene ID" value="BLA24_09240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16178">
        <property type="protein sequence ID" value="PPT16178"/>
        <property type="gene ID" value="CYQ11_27850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="544" mass="58925" checksum="35DD4D50A7618717" modified="2018-01-31" version="1">MGENQPPSRRSVLAAATLGAAALTGAAGLVTAPRARAGGRGGGDAFVPAVVVGTGYGAAVCALRLAEAGVETLMLEMGRRWDGPGADGSVFCGMLRPDERSSWFKSRTEAPLSTFLWLDVVNRNIRPYAGVLDRVRFDGMSVYVGRGVGGGSLVNGGMAVTPRRSYFEEVLPQVDAGEMYERYFPRANAALRVNRIDKAWFEQTEWYKYARVSRTQAARAGLGTVFVPNVYDFGHMRREAAGEVPRSALATEVIYGNNHGKMSLDKTYLAAALRTGKVTIRPLHRVTTIERRRDGTYLLGAEETDAHGAPLGRREISCTHLFLGAGSLGTTELLLRARETGTLPDLPPEIGTGWGPNGNVMTARANHLWNPTGPHQSSIPALGIDDWDNPAAPVFAEIAPIPAGLETWASLYLAITKNPERGTFTYDKATDRLGLRWTRDQNAPAVRAAKSLFDRVNRANGTMYRYDLFGGGLRNFADDFCYHPLGGCVLGRATDLHGRVRGYRNLYVVDGSLIPGSIGVNPFVTITALAERNIERVIAQDVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLQ6</accession>
    <name>A0A2G1XLQ6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_09180</name>
        <name evidence="4" type="ORF">CYQ11_27790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000097">
        <property type="protein sequence ID" value="PHQ52175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52175">
        <property type="protein sequence ID" value="PHQ52175"/>
        <property type="gene ID" value="BLA24_09180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16840">
        <property type="protein sequence ID" value="PPT16840"/>
        <property type="gene ID" value="CYQ11_27790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304971" evidence="1">
        <location>
            <begin position="26"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="103"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="528" mass="56846" checksum="B67A97C57D65FED8" modified="2018-01-31" version="1">MAGAAGTVVTGALVAGFLAAPSAGAAQAVPGGAAEAKGVKIAAERAAKAGVNWQDCPADWGLDKPIQCGWVTVPVDYAKPNGRTIKIAVDRARSTGTASERQGSLVYNPGGPGGSGLSFPKRVTTNNPLYANIAKAYDFVGFDPRGVGHSAPISCVDPQEFVKAPKADPVPSSEADKRAQRKLAKEYADGCAERSGDMLPYMTTPNTARDVDVVRAALGDKKLNYLGVSYGTYLGAVYGTLFPTHVRRMIVDSVVNPDRENIWYQANLEQDVAFEGRFKDWEEWVAKNDASFHIGDTRAKVHAEWEKLRATAKKQPVGGLVGPAELINYFQGAAYYDRSWVPVAETWKKYRAGDEKALVQAAGPDLTDRAGNISSENGNAVYTAVECADAKWPTSWRQWDRDNTRVHRQAPFMTWANAWMNLPCATWKGPQYNPVEVTTHKGLPQTLIVQSERDAATPYAGAVELHERFRGSQLITEKDAGSHGVTGLVNPCVNQRVDAYLLTGKLQGGSDVTCAPHATPEAPKAGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XLX4</accession>
    <name>A0A2G1XLX4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl Co-A mutase-associated GTPase MeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08730</name>
        <name evidence="3" type="ORF">CYQ11_03990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52238">
        <property type="protein sequence ID" value="PHQ52238"/>
        <property type="gene ID" value="BLA24_08730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12171">
        <property type="protein sequence ID" value="PPT12171"/>
        <property type="gene ID" value="CYQ11_03990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="335" mass="35902" checksum="0390277840B28633" modified="2018-01-31" version="1">MASPARRTIDVDAYVKGVLDGKRAAVARAITLVESTRADHKALAQRMLTELLPHAGAARRIGITGVPGVGKSTFIDAFGTMLTGLGHRVAVLAVDPSSSRTGGSILGDKTRMERLAVDPEAFVRPSPTAGTLGGVAKATRETIVVMEAAGYDVVLVETVGVGQSETAVANMVDTFLMLTLARTGDQLQGIKKGVLELADVVAVNKADGPHERDARSAARELAGALRLMQSPDAAWNPPVLTCSAREGTGLDTLWERVEAHRRVLDATGELAGRRRDQQVDWTWTMVREQLLAELRDHPEVRRVGPALEQRVREGTLTASLAAERLLEAFRSPGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM00</accession>
    <name>A0A2G1XM00_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TnsA-like heteromeric transposase endonuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_08935</name>
        <name evidence="2" type="ORF">CYQ11_04190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52272">
        <property type="protein sequence ID" value="PHQ52272"/>
        <property type="gene ID" value="BLA24_08935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12204">
        <property type="protein sequence ID" value="PPT12204"/>
        <property type="gene ID" value="CYQ11_04190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="253" mass="29177" checksum="84158E77A98E8E82" modified="2018-01-31" version="1">MEALSRAYGDEALTAFELDFLSDGERRRLPLGASWQVSFEAVEPVRPFRWDKGTPGFAGWYYSATMRDHVGYESWLERDRLILLDRDPQVRAIASQPFWLHWHDGRRQRRHAPDYFVRLAAGQAQVVDVRAEEDMDQRTREAFAATERACAAVGWQFEWVGRPDPVVMANVRWLARYRRARSGRPVVVAERLLEVFSEPKGLWEGAELVGDRIQVLPVLFHLLWLGKLETDLSGGLLETGSLVWAKGRRRWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM12</accession>
    <name>A0A2G1XM12_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_08325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000089">
        <property type="protein sequence ID" value="PHQ52304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52304">
        <property type="protein sequence ID" value="PHQ52304"/>
        <property type="gene ID" value="BLA24_08325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="113" mass="11925" checksum="73C62C58B7B63F6E" modified="2018-01-31" version="1">MPEQHGDVPPEGTRISAEYHVYRGRKGSLPIGTPLTVVSQAGLSATADGVLAPAEDAEDWRQALERAGLGLTPLRRAVTAADHEQIIGNTWPGWPGSGSRRSPGPPTHACRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM27</accession>
    <name>A0A2G1XM27_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08900</name>
        <name evidence="4" type="ORF">CYQ11_04155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000093">
        <property type="protein sequence ID" value="PHQ52266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52266">
        <property type="protein sequence ID" value="PHQ52266"/>
        <property type="gene ID" value="BLA24_08900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12198">
        <property type="protein sequence ID" value="PPT12198"/>
        <property type="gene ID" value="CYQ11_04155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="175" mass="18428" checksum="5CB08FBE549BE813" modified="2018-01-31" version="1">MQSRTPDSGWAGSANDSRLSMELASAVAGARRRAARDGDRQVDTAHLLHTLLEADPEARAAFDGGPAQVARLLGYLVQRTIGYGLRWSGTVEDSGALPVLPGDGVPGWSPAAAEAMREAHVRALARRSGPVRGTDLLAALLRDRQCRAVDVLHRAGVDTALLATRLAHAACSECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM54</accession>
    <name>A0A2G1XM54_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_08230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000086">
        <property type="protein sequence ID" value="PHQ52317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52317">
        <property type="protein sequence ID" value="PHQ52317"/>
        <property type="gene ID" value="BLA24_08230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="93" mass="10253" checksum="A4B331A83DDA5498" modified="2018-01-31" version="1" fragment="single">MSRVLLIEDDRAVREGVTLTLRRRGHDVEAAPTGEAGLAALETFRPDLVLLDLMLPDKSGFEVCRRIRATQQIPIIMLTARGDDIDVVLGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM77</accession>
    <name>A0A2G1XM77_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4238 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07615</name>
        <name evidence="3" type="ORF">CYQ11_00045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52323">
        <property type="protein sequence ID" value="PHQ52323"/>
        <property type="gene ID" value="BLA24_07615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11526">
        <property type="protein sequence ID" value="PPT11526"/>
        <property type="gene ID" value="CYQ11_00045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="316" mass="36232" checksum="C300FB37AA2BE035" modified="2018-01-31" version="1">MPQMYLKHFAKHVARRKYELKVRRLDKINEPFPVTPTGIAAETGYYWGISAEGVPHHAVEELFTSLEGHTETVLKVLLSDPDWALTPHWPLRPDQRHVLAWWMAAQILRTTRQRKRLTHLQTEAPDITGLPQEVHTLAQNNPHLRYIVENIVTLALILEARPWALGFSDMCLLTSDTPIAIWNRPDDEDQLRAAALSDILLPLDPHRFLFLPGPATRGTDRRKHVDHLMHAEGAIGFALVEVAYDVADQFVIHHPEHDPWKHWKPNSPGQPKPWDGQTHSAPQYILEYGVFPPSQNIERRWTVEHPPPRSPAVSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XM86</accession>
    <name>A0A2G1XM86_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07905</name>
        <name evidence="3" type="ORF">CYQ11_00340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000084">
        <property type="protein sequence ID" value="PHQ52365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52365">
        <property type="protein sequence ID" value="PHQ52365"/>
        <property type="gene ID" value="BLA24_07905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11568">
        <property type="protein sequence ID" value="PPT11568"/>
        <property type="gene ID" value="CYQ11_00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="94" mass="9804" checksum="E8720DF087485079" modified="2018-01-31" version="1">MLILNSKTRHRGLFPVTASMTTALPLAAILPAMTMTFSDQLGTSATIALILAGLALIACTAGLTARAAARNSSEQARRDQAVLDALEPLAGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMJ1</accession>
    <name>A0A2G1XMJ1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_06530</name>
        <name evidence="2" type="ORF">CYQ11_26680</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52436">
        <property type="protein sequence ID" value="PHQ52436"/>
        <property type="gene ID" value="BLA24_06530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15968">
        <property type="protein sequence ID" value="PPT15968"/>
        <property type="gene ID" value="CYQ11_26680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ52436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="357" mass="39625" checksum="42AF77AA8F8C3D2B" modified="2018-01-31" version="1">MEQHERLGEAQKIRLYLHTTRQRAFIRERLHPLLADFSRQHLLPVRLMRRGWLHGPHVELVVRPHGGRTCDVAELAPRLAGAVHGITPEPVDEDAYLRRAGQLGRMENVPGPYLPVHAHGTVDVPAMGDDDRWPRPLGDVRDAVLTALTDAACAETEPDAARRRTRLAAVMAALAASSPVGLGLGAMSYRSHSEAFFALSPHTDVRAAFTRRFEQEGDAFREVVRRQLSSGTPTDLRPWTSAFTYGWGALDALGSAGVLTAETVAAISADQAGRATARPKTHFHRTFDDLGLLDRPAHWFLAYRCLLNFLYTALPLLDVTPVERYYLCFALSEALDQETGSTWEQRLDDVRDELTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XMQ7</accession>
    <name>A0A2G1XMQ7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_07065</name>
        <name evidence="3" type="ORF">CYQ11_27220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52527">
        <property type="protein sequence ID" value="PHQ52527"/>
        <property type="gene ID" value="BLA24_07065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16064">
        <property type="protein sequence ID" value="PPT16064"/>
        <property type="gene ID" value="CYQ11_27220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="307" mass="31295" checksum="7A9D24AFA890930B" modified="2018-01-31" version="1">MTGICAGRVAVVTGAGRGLGRAHALALAAEEARVVVNDLGTTPAGEGASAGPAHEVVEEIRARGGEAVAHTGDVATAEGAASLVDTALAAYGRLDALVNNAGFLRDRMLVNLDEDEWDAVVRVHLKGHFLPLRYAAGHWRAEAKAGREPVARVVNTTSGAGLLGSVGQANYAAAKAGVAALTLVAAAELGRYGVQVNAVAPAARTRMTEGPFAAAMAAPADGFDAMAPANVSPLVVWLASAASAEVTGHVFEAEAGRVTVMEGWHPGPVADKGDRWAPSEVGEAVRELLARTRMPRPVYGAASPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN02</accession>
    <name>A0A2G1XN02_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_07425</name>
        <name evidence="4" type="ORF">CYQ11_27575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52590">
        <property type="protein sequence ID" value="PHQ52590"/>
        <property type="gene ID" value="BLA24_07425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16127">
        <property type="protein sequence ID" value="PPT16127"/>
        <property type="gene ID" value="CYQ11_27575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ52590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT16127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="288" mass="28290" checksum="09BD7555F1938B93" modified="2018-01-31" version="1">MTPVFALATSLMWGLADFGGGLLTRRMPALTVVLVSQLLAVGALGAVVVATGGWSEAGPQLWYAVAAGVVGPAAMLAFYKALALGPMGVVSPLGALGGVAVPLGVGLVLGERPGILQFAGIAVAVAGVVLASGPGLGGAPVQRQTLVLTLVAAFGFGSVMALISEASHNVTGLFLALFVQRLCNVVVGAGSLYVSARRGAAVLPPEGWGTVRSALPALAFVGLADVAANGTYSVAAHNGPVTVAAVLASLYPVVTALAARGVLREKLRAVQAAGAGLALVGTVLLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XN25</accession>
    <name>A0A2G1XN25_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_07190</name>
        <name evidence="5" type="ORF">CYQ11_27345</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000081">
        <property type="protein sequence ID" value="PHQ52549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52549">
        <property type="protein sequence ID" value="PHQ52549"/>
        <property type="gene ID" value="BLA24_07190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16087">
        <property type="protein sequence ID" value="PPT16087"/>
        <property type="gene ID" value="CYQ11_27345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="508"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="811"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT16087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="980" mass="104217" checksum="C75087526F484E0D" modified="2018-01-31" version="1">MTPLPVAPPSDLRRLVHCSAAFLPGDPARTGRVAFWQPDGTPPVATDAVEELTVAVPDGSDVSTRTVRARVLPVRDALPVLTRARAARADEAAAFWGSAAVLALQLAARGKLLPGLSATDHDAWRVGPLAPDDFRRVRELAAAMPPAAHAVPLPDSDPLLLPDPEQLLRAFLDAVADGLPRSPAAALATGGPAFTAPEPQRLPEQRAWAADVAAGHDAGVRLSLRVEVLGPDGALTDTGEPDDEDVHPRFRAVLQLHSLADPALVADAADVWSGTSPVAAALGRGARMNALLALRRAAHAWPALSPLLSEAAPAAIDLADDEAGELLGAGSRALDAAGVEVHWPKELARTLTARAVVGSPDDDDEAAPDRRSGLPSLLSADALLSFGWRFAVGDRELTRAELDRLAEASRPAVRLRDRWVLVDPEAVRRAHERRDRKVSPVEALGAALTGRALAGDGDETVEVEATGRLAALRDAIADPEAVREPVAPPAALAATLRDYQLRGLDWLSRMTSLGLGCCLADDMGLGKTVTLIALHLHRQTLPGAAGPTLVVCPTSLMGNWQREIERFAPGTPVRRFHGSSRNLDGVADGEFVLTTYGTMRLDAPRLAGTGWGMVVTDEAQHVKNPYSATAKALRTIGAKARVALTGTPVENNLSELWAILDWTTPGLLGSLNAFRRRYAQAVEGGADPAAAERLSALVRPFLLRRRKSDPGIAPELPPKTETDHAVTLTREQAGLYEAVVREILAEISAADGLERRGLIVKLLTGLKQICNHPAQFLKELGTKGKDAKGSGRKDARAGGPRIAGRSGKVELLDELLETILAEGASVLVFTQYVQMARLLEDHLAARGVPTQFLHGGTPVAQREEMVRRFQAGEVPVFLLSLKAAGTGLNLTRAGHVVHFDRWWNPAVEAQATDRAYRIGQTQPVQVHRLVTEGTIEDRIAEMLSRKQALADAVLGAGEAALTELTDAELAELVALRGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XNI1</accession>
    <name>A0A2G1XNI1_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF4142 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_05775</name>
        <name evidence="4" type="ORF">BLA24_09765</name>
        <name evidence="6" type="ORF">CYQ11_02250</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000100">
        <property type="protein sequence ID" value="PHQ52055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000072">
        <property type="protein sequence ID" value="PHQ52773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52055">
        <property type="protein sequence ID" value="PHQ52055"/>
        <property type="gene ID" value="BLA24_09765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52773">
        <property type="protein sequence ID" value="PHQ52773"/>
        <property type="gene ID" value="BLA24_05775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11874">
        <property type="protein sequence ID" value="PPT11874"/>
        <property type="gene ID" value="CYQ11_02250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ52055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ52773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="277" mass="29130" checksum="71C0136F15F7F314" modified="2018-01-31" version="1">MRSVRPTHATTAGLIRTLARWTRPEGGRPAAGRAVGTWLVVGALAATLVALLVPVSLFGSARPAAAAGPAWSDDGAGVQNTAFGPLSALDRDFVRKVRLAGLWEKPAGRLAQERGTTEDVRVAGEHLIGGHTELDRRSLDAGRVLGISLPDRPSAQQQGWLDQMDAARGTAFDRAFAQLVRAAHGKVFGLVALVRDRTGNSLVRELATRANTVVLDHITVLENTGQAGVPHTDPRPASPAGTPAMPQAPASPHDPAPSQDPASPQAPARQHSYEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XP41</accession>
    <name>A0A2G1XP41_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_04985</name>
        <name evidence="3" type="ORF">CYQ11_28545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000070">
        <property type="protein sequence ID" value="PHQ52980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000002">
        <property type="protein sequence ID" value="PPT11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ52980">
        <property type="protein sequence ID" value="PHQ52980"/>
        <property type="gene ID" value="BLA24_04985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT11507">
        <property type="protein sequence ID" value="PPT11507"/>
        <property type="gene ID" value="CYQ11_28545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="137"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ52980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="265" mass="27589" checksum="112EE1ED91ED1B8B" modified="2018-01-31" version="1">MITTDFLAGSPCWIDLGARDVTAAAAFYDAVFDWEFESLGPEANGYGIFKNDGRIVGAVGPLTETGARSAWMIYFNTPDADATARTVERLGGAVRVAPLDADGAGRMAQFTDPQGGQFAIWQPGTSRGLEQTDAPGALAWTELYTTDAAAAKKFYGSLFGWETSDIPLPGDGGTYSLVTPAGKGQERMQGGVMQVGSEALTLNGGRPYWHPVFAVVDCDTTVAAVTGNGGSVQMGPEDAEGVGRLAVCLDPFGADFVVLAPAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPG4</accession>
    <name>A0A2G1XPG4_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000052">
        <property type="protein sequence ID" value="PHQ53081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53081">
        <property type="protein sequence ID" value="PHQ53081"/>
        <property type="gene ID" value="BLA24_03755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="52"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="331" mass="35850" checksum="7973AE42A8EFAD11" modified="2018-01-31" version="1">MLPAGQLEQLPGGSTAAGHHARVAPGRLGGHRALPAARGAVRDAPPGPRPERATRYDRYLEHQRRLLDTEEVAEAGRYWSRRLAGELPVLELARKQRPATPGYHGATVEAVLDADLTRRLNETALAASATAFVPLLAAYALALGYYGDAEEVIVGAPMAGRERPEAADVPAFTLAMLPLRLRMDPDVPLAEFTAQVRETVHDAYAAADHPFGWTLRRLPAATRSSAATPVFQTMLNMLPYPARETTAAGVGFRFVELDTGYTKYDCALYVQPHGTDRLLLQYAYQRELLEAQAARDVLASTLTALRALTDPARATGTTIRSLDLLPGGEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPR9</accession>
    <name>A0A2G1XPR9_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GuaB1 family IMP dehydrogenase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_02440</name>
        <name evidence="9" type="ORF">CYQ11_04805</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53213">
        <property type="protein sequence ID" value="PHQ53213"/>
        <property type="gene ID" value="BLA24_02440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12305">
        <property type="protein sequence ID" value="PPT12305"/>
        <property type="gene ID" value="CYQ11_04805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005991">
        <property type="entry name" value="IMP_DH-rel1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01303">
        <property type="entry name" value="IMP_DH_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="154"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="480" mass="50548" checksum="399F28454545D74D" modified="2018-01-31" version="1">MRFLNDQKPSYDLTYDDVFMVPSRSAVGSRQGVDLSAPDGTGTTIPLVVANMTAIAGRRMAETVARRGGLVVIPQDIPIEVVAEVISWVKGRHLVLDTPIVLAPTQTVADALSLLPKRAHGAGVVVDADHRPVGVVTEHDLTGVDRFTQLSEVMSTELLLLDADIDPREAFNKLDAAHRKLAPAVDKDGKLAGILTRKGALRATLYTPAVDEDGKLRVAAAVGINGDVAGKAKALLDAGADTIVVDTAHGHQESMIAAIKAVRALDPRVPIVAGNIVAAEGVRDLIEAGADIIKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEAKKYGKHVWADGGVRHPRDVAMALAAGASNVMIGSWFAGTYESPGDLQQTADGRLYKESFGMASARAVRNRTSEESAYDRARKGLFEEGISTSRMFLDPGRPGVEDLIDSIIAGVRSSCTYAGAGSLEEFAERAVVGVQSAAGYAEGKPLHASWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XPS4</accession>
    <name>A0A2G1XPS4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase family 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_02040</name>
        <name evidence="7" type="ORF">CYQ11_04400</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53149">
        <property type="protein sequence ID" value="PHQ53149"/>
        <property type="gene ID" value="BLA24_02040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12239">
        <property type="protein sequence ID" value="PPT12239"/>
        <property type="gene ID" value="CYQ11_04400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="201"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ53149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="392" mass="41502" checksum="9A987949E21F715B" modified="2018-01-31" version="1">MRVVIVTESFPPDVNGVAHCAWQTARHLVLRGHEPLVVAPAGPRGDEPDTGARQPGADGPCPVVRVPSVPLPGRPQVRVALPGRRLTDALTAHRAQVVHLASPFVLGARAMTAATRLGLPAVAVYPTDLGGHARAYLGVGEGLARRRLRAVHRAADRTLAPSAAAARDLAGHGVPRVWLWPRGVDSERFHPARRDPELRRALAPGGELIVGYVGRLAPEKHVELLARVCALPGVRLLVVGGGPRAARLRAALPGARFLGTRTGDELARIFASLDVFVHPGTQEAFCHTVQEAHASGVPVIAPAAGGALDLVRHARTGLLVRPHDAEALREAVQTLESAPRLRAAYGSAGRASVLGRTWAVVGDQLLGHYDEVLDERAARGCPARRATEGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ06</accession>
    <name>A0A2G1XQ06_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">BLA24_02865</name>
        <name evidence="13" type="ORF">CYQ11_05160</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53271">
        <property type="protein sequence ID" value="PHQ53271"/>
        <property type="gene ID" value="BLA24_02865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12365">
        <property type="protein sequence ID" value="PPT12365"/>
        <property type="gene ID" value="CYQ11_05160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="64"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PHQ53271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PPT12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="188" mass="19425" checksum="5BDEC335BF01BBC5" modified="2018-01-31" version="1">MSATRASGADQDLRDLLLSRIHDVPDYPKPGVMFKDITPLLADAEAFGALTDAFVALCAHHGATKVVGLEARGFILAAPVAVRAGLGFVPVRKAGKLPGATLAQSYELEYGTAEIEMHADALDAGDRVLVIDDVLATGGTAEASLQLIRRAGAEVAGVAVLMELGFLPGRARLESALAGAPLEALITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ78</accession>
    <name>A0A2G1XQ78_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_03065</name>
        <name evidence="4" type="ORF">CYQ11_05365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000037">
        <property type="protein sequence ID" value="PHQ53299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53299">
        <property type="protein sequence ID" value="PHQ53299"/>
        <property type="gene ID" value="BLA24_03065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12396">
        <property type="protein sequence ID" value="PPT12396"/>
        <property type="gene ID" value="CYQ11_05365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ53299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="67" mass="6839" checksum="B77AD23739FE056F" modified="2018-01-31" version="1">MADLARDTGRPAHHRAADVLGDRPSSTRHPLVAAAMVLPLAALLAVAFGGWDAVVIQASSVAGILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQ99</accession>
    <name>A0A2G1XQ99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WXG100 family type VII secretion target</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_01125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000013">
        <property type="protein sequence ID" value="PHQ53414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53414">
        <property type="protein sequence ID" value="PHQ53414"/>
        <property type="gene ID" value="BLA24_01125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="88" mass="9685" checksum="737ABE4D4533EF22" modified="2018-01-31" version="1">MHDTLEGRITALNGVIDSVEGHWKGIAANAYNELQRQVNDDVRRLKELLSFTKDAIVASDKGFTQEEHNQLNNFKGVASAGILGRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQB8</accession>
    <name>A0A2G1XQB8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_01115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 21532</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000013">
        <property type="protein sequence ID" value="PHQ53413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53413">
        <property type="protein sequence ID" value="PHQ53413"/>
        <property type="gene ID" value="BLA24_01115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ53413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <sequence length="148" mass="16029" checksum="C8F15AC6FFC9FA2D" modified="2018-01-31" version="1" fragment="single">SADDQFDFVTLDPATGKEKARIAYNRNWRLGDCFLVTSGCTGALVDQDSLYVAGQGLTYAYDLTGGKERWTYKGDANRSTAPVAVHDGRLAVYTPATSDRPGRLAYVATSSGKALRTVDHSNDARDARTRPSWAGSRGSRAWWTSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQI1</accession>
    <name>A0A2G1XQI1_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">BLA24_00755</name>
        <name evidence="9" type="ORF">CYQ11_07765</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53494">
        <property type="protein sequence ID" value="PHQ53494"/>
        <property type="gene ID" value="BLA24_00755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12799">
        <property type="protein sequence ID" value="PPT12799"/>
        <property type="gene ID" value="CYQ11_07765"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="354" mass="37667" checksum="62728EFD859F3C18" modified="2018-01-31" version="1">MNQILFAGVIGLFLTLIGTPLLIKFLARKGYGQFIRDDGPRGHAGKKGTPTMGGIAFILATLIAYAATKVITSREPTTSGLLVLFLTAGMGLVGFLDDYIKIVKQRSLGLRAKAKMAGQLIVGIAFAVLALQFSDTRGQTPASTRLSFTQDFGWSVGPVIFVVWALFMILAMSNGVNLTDGLDGLATGASVMVFGAYVFIGTWQHGQSCANPLTAGAGCYEVRDPLDLAVVASALMGSCFGFLWWNTSPAKIFMGDTGSLALGGALAGLAICSRTELLLALLGGLFVLITMSVIIQVGSFRLTGKRVFRMAPLQHHFELKGWSEVLVVVRFWIIQGLCVAVGLGIFYAGWLAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XQR2</accession>
    <name>A0A2G1XQR2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BLA24_01060</name>
        <name evidence="9" type="ORF">CYQ11_08070</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">DSM 41675</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000012">
        <property type="protein sequence ID" value="PHQ53550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ53550">
        <property type="protein sequence ID" value="PHQ53550"/>
        <property type="gene ID" value="BLA24_01060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12855">
        <property type="protein sequence ID" value="PPT12855"/>
        <property type="gene ID" value="CYQ11_08070"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033304821" evidence="5">
        <location>
            <begin position="27"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="55"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="243"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PHQ53550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PPT12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="415" mass="43973" checksum="42ED89079BB954DE" modified="2018-01-31" version="1">MSHSPRRRTAEVLALLLVSLALGASACGGSSNPLADKPYDASASVGLAGARAGHKVDPSKPLEVTATGGDHITDVTATDAAGRYVKGELAADGSSWHSTAPLAAGAHYTVRVSTEDEEGAQGRRTIGFDTNPADRLLRVAFGPQSGKYGVGQPITAELSIPVQDPAARAVIERTLRVDAQPAVQGAWHWVDNRTLHYRPQDYWPANSVIEAHATLDGIKVAPGLYGGPSKPVRLTIGDRVEAVTDAAAHYMTVMKNGKTVRTIPVTTGKPGYATRNGVKVVLGQESFVRMRGTSIGIAEGSSDSYDLPVYWATRVTWSGEYVHAAPWSVGSQGADNVSHGCTGMSTENAKWFFDNVRVGDVVKVVGSAGATMTPFDNGFGDWNMPWKQWREGSALMAGKREGTSPADAARLRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X995</accession>
    <name>A0A2G1X995_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3046 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_30250</name>
        <name evidence="2" type="ORF">CYQ11_23345</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47796">
        <property type="protein sequence ID" value="PHQ47796"/>
        <property type="gene ID" value="BLA24_30250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15421">
        <property type="protein sequence ID" value="PPT15421"/>
        <property type="gene ID" value="CYQ11_23345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ47796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="64" mass="7475" checksum="279EF15692F88F2B" modified="2018-01-31" version="1">MRLTVFWQRMADYFGESYADSFARDHVMSELGGRTVHQALDAGWNAKDVWRAVCRALEVPEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9E2</accession>
    <name>A0A2G1X9E2_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_30560</name>
        <name evidence="10" type="ORF">CYQ11_23655</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47854">
        <property type="protein sequence ID" value="PHQ47854"/>
        <property type="gene ID" value="BLA24_30560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15479">
        <property type="protein sequence ID" value="PPT15479"/>
        <property type="gene ID" value="CYQ11_23655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="21"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ47854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="819" mass="88377" checksum="BB41296B9EE205E0" modified="2018-01-31" version="1">MARRSTKTPPPEEFEERILDIDVVDEMQGSFLEYAYSVIYSRALPDARDGLKPVQRRIIYQMNEMGLRPERSYVKCARVVGEVMGKLHPHGDASIYDALVRMAQPFSMRVPLVDGHGNFGSLGNDDPPAAMRYTEARMAAATSLMTDSIDEETVDFTPNYDGSEREPVALPSAYPNLLVNGSSGIAVGMATNMPPHNLGEVVAAARHLIKHPGADLETLMRYVPGPDLPTGGRIVGLAGIRDAYETGRGTFKIRATVSVENVTARRKGLVVTELPFTVGPEKVVSKIKDLVGAKKLQGIADVKDLTDRAHGLRLVIEIKNGFNPEAVLQQLYKLTPMEESFGINNVALVDGQPLTLGLKELLEVYVDHRFEVVRRRSEFRRTKRRDRLHLVEGLLVALLDIDEVIRIIRSSENAAAAKESLVARFSLSEVQTQYILDTPLRRLTKFDRIELESERDRLHQEIEKLTQILESDAELRKLVSSELADVAKKFGTDRRTVLLESAGAPASAVPLQVADDPCRVLLSSTGLLARTATGEPFPPGAGEAKRVKHDAIVSAVPATALGEVGAVTSAGRLLRLRVIDLPQLPETAAAPNLAGGAPVPEFLSLEDGERVVCLTTLDESSPGLAIGTEQGVVKRVVPDYPANKDELEVITLKDGDRIVGAAELRTGEEDLVFVTDDAQLLRYQASQVRPQGRPAGGMAGIKLSSGAKVISFTVVDPAEDAVVFTVAGARGGLPGDVSEGSAKLTPFDQYPRKGRATGGVRCQRFLKGEDCLVLAWAGLAPARAADAKGSPVPLPDPDPRRDGSGTPLPKPVAVVAGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9F4</accession>
    <name>A0A2G1X9F4_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Insulinase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_30565</name>
        <name evidence="5" type="ORF">CYQ11_23660</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47855">
        <property type="protein sequence ID" value="PHQ47855"/>
        <property type="gene ID" value="BLA24_30565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15480">
        <property type="protein sequence ID" value="PPT15480"/>
        <property type="gene ID" value="CYQ11_23660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="185"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ47855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="450" mass="49141" checksum="FC3687140DA55C2A" modified="2018-01-31" version="1">MGHTATQQAGSGGLTATEHRLANGLRVVLSEDHLTPVAAVCLWYDVGSRHEVKGRTGLAHLFEHLMFQGSAQVKGNGHFELVQGAGGSLNGTTSFERTNYFETMPAHQLELALWLEADRMGSLLTALDEESMENQRDVVKNERRQRYDNVPYGTAFEKLTAMAYPDGHPYHHTPIGSMADLDAASLEDARNFFRTYYAPNNAVLSVVGDIDPERTLAWIEKYFGSIPGHDGKQPPRDGTLPDTIGEELREVVREEVPSRALMAAYRLPHDGTREGDAADLALTILGGGESSRLHNRLVRHDRSAVAAGFGLLRLAGAPSLGWLDVKASGGVEVPDIESAVDEELARFALEGPTPQEMERAQAQLEREWLDRLATVSGRADELCRFAVLFGDPQLALTAVHRALDITPEEVQAVAKARLHPANRAVLVYEPTSPQADADATGKNEEEETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9P9</accession>
    <name>A0A2G1X9P9_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BLA24_31025</name>
        <name evidence="12" type="ORF">CYQ11_24125</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47935">
        <property type="protein sequence ID" value="PHQ47935"/>
        <property type="gene ID" value="BLA24_31025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15560">
        <property type="protein sequence ID" value="PPT15560"/>
        <property type="gene ID" value="CYQ11_24125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PHQ47935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PPT15560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="225" mass="23486" checksum="044E21D584615AE0" modified="2018-01-31" version="1">MARIDVDLAVKTFSEHGTAAVSDAMDLLGLNGGLERLTRMSGEGTKAGPAYTLGFETVSPGVPAPAAEFIDDVPPGSVVVIANRGRTHCTVWGDILTAVAVRSGLAGTVIDGCCRDLDDIRALGYSVWSLGAYMKSGKNRVRLVTRQEPVEIGDTVVHPGDLVCADGAGAIAVPAAHVTEVTGNVLRVAGMEAAVRVDVAAGTPLREARRLHGYNQMSLRPRKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9R3</accession>
    <name>A0A2G1X9R3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly-gamma-glutamate synthase PgsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pgsB</name>
        <name evidence="3" type="ORF">BLA24_31515</name>
        <name evidence="4" type="ORF">CYQ11_24560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47987">
        <property type="protein sequence ID" value="PHQ47987"/>
        <property type="gene ID" value="BLA24_31515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15612">
        <property type="protein sequence ID" value="PPT15612"/>
        <property type="gene ID" value="CYQ11_24560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008337">
        <property type="entry name" value="Capsule_biosynth_CapB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01758">
        <property type="entry name" value="CAPSULEPROTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04012">
        <property type="entry name" value="poly_gGlu_PgsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="41"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="419" mass="45762" checksum="4FA2A3632D2F22A9" modified="2018-01-31" version="1">MLFLYTVLVICCAVVLVAGVIEQRRHFTNLDLIPTRVLVNGIRGKSSITRLCAGALRGGGLVTVAKTTGTAARFIHPDATEEPVYRKFGIANVVEQIGIVRRAAAYRPHALVIECMAVMPALQEVNQTKLIRSTIGVLCNVREDHLAEMGPTLDDVARSLSRSMPLGGVCVTAERDRLHILREEAAKRDCRLVSVNPETVTDAELRGFSWFTFKENVAIALAVAELLGVDRATALQGMYDAPPDPGVLSVERYLTPEGTPFRFANVFAANDPESTLMNVEQLLSLGAVERPLHVLINCRPDRVERNGQMGEIVPRLAPDSVFLIGHPTKSAHDAIPAEWREKVVDLGGDRRDPAELEREILGRLGPGASLVAIGNIHGQGELLLERLAELPADESAQSRQPEEPPVYVPTYIDPTGDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9U6</accession>
    <name>A0A2G1X9U6_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrB</name>
        <name evidence="5" type="ORF">BLA24_31665</name>
        <name evidence="6" type="ORF">CYQ11_24720</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48014">
        <property type="protein sequence ID" value="PHQ48014"/>
        <property type="gene ID" value="BLA24_31665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15640">
        <property type="protein sequence ID" value="PPT15640"/>
        <property type="gene ID" value="CYQ11_24720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="135" mass="15323" checksum="12FBB55690E5FED8" modified="2018-01-31" version="1">MTYEVEKTDEQWRAELTPAEYEVLRRAGTEPAFRGEYTDTKTEGVYACRACGAELFRSTEKFESHCGWPSFYDPKDSSAVELVEDRSHGMVRVEVRCARCGSHLGHVFEGEGYPTPTDQRYCINSISLRLEPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9V0</accession>
    <name>A0A2G1X9V0_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_31540</name>
        <name evidence="4" type="ORF">CYQ11_24590</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ47991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ47991">
        <property type="protein sequence ID" value="PHQ47991"/>
        <property type="gene ID" value="BLA24_31540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15617">
        <property type="protein sequence ID" value="PPT15617"/>
        <property type="gene ID" value="CYQ11_24590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="244"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ47991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="425" mass="45820" checksum="09F18F74EDDAFB27" modified="2018-01-31" version="1">MTDAQETAEDTTLRTTGGGPPDDVDSAPVPLLEPREGMPPVVADADALADVVAAFAAGTGPLAVDAERASGYRYGQRAYLVQLRREGAGTALIDPVGCPDLSALGEAVADAEWVLHAATQDLPCLREIGMTPTRLFDTELAGRLAGFARVGLGAMVENVLGYALEKGHSAVDWSTRPLPEPWLRYAALDVELLVDLRDALERELDRQGKLEWARQEFDAIASAPPAPPRKDPWRRTSGMHKVRRRRQMAVVRELWTVRDHIAQRRDVSPGKVLGDAAIVEAALNIPPNVHALAALPGFGHRMSRKQLEQWMAAVDRAKALPDAELPQPGQPLTGPPPPRAWADKDPVAAARLSAARAAVSELAERLTMPQENLITPDTVRRLCWEPPKAATSEAVAEVLSAHGARAWQVEQVTPVLVKALTEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1X9Z8</accession>
    <name>A0A2G1X9Z8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_31900</name>
        <name evidence="2" type="ORF">CYQ11_24955</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48056">
        <property type="protein sequence ID" value="PHQ48056"/>
        <property type="gene ID" value="BLA24_31900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15682">
        <property type="protein sequence ID" value="PPT15682"/>
        <property type="gene ID" value="CYQ11_24955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045682">
        <property type="entry name" value="DUF6193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19692">
        <property type="entry name" value="DUF6193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT15682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="123" mass="13025" checksum="8A1B3281DBFE0BCE" modified="2018-01-31" version="1">MSAQDGKSAAAETVALAWQRVLSLEEDLLAPEIARAAYAEPRLRELFPLVSHGALTLSRCTRSPWSNDVPTLYRRAGGGYVVIRYGEGRLGEPDTVEEAVALIVANLPAGCGAAVDGTADDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA08</accession>
    <name>A0A2G1XA08_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_31925</name>
        <name evidence="10" type="ORF">CYQ11_24980</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48060">
        <property type="protein sequence ID" value="PHQ48060"/>
        <property type="gene ID" value="BLA24_31925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15686">
        <property type="protein sequence ID" value="PPT15686"/>
        <property type="gene ID" value="CYQ11_24980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="568"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="1101" mass="118743" checksum="8F6DAC370AB783FA" modified="2018-01-31" version="1">MTGLPAHYPPLPLAEGAREKALMAALARSEPYPTQDGVHAHVQRHAAAHPDRVAIEDGPHTVTYAALADRMRRAATGLAAAGAGAGRVVAVGGRRGADVVTAFLALELLGAVYLPVDTTWPADRVRSVLADSGAALLVTTGPPEDHESLTKGATAAGTPAVPLPLTGDPYTRTTPPAPDEIRYVLYTSGSTGRPKGAVIEHRGMLNHLWAKVDDLGLTEDDRLAQTAPLSFDISVWQMLAPLLPGGRVQIYDDAQAQEGAALLHTALRSRTTVLETVPTLIRFLLDAHDADGTRPDALRWMIATGEELPPALARRWTATFPGTALLNAYGPTECSDDVTHAVLTSPDPDVRHLPIGGPIGNAVLYVLREEDGRWQACAHGETGELFVGGVVVGRGYLGDPERTARAFFADPFTGGAGRLYRTGDAVRVLPGEQLEYTGRIDRQVKIGGVRMELAEIEAVLAAHPQVAACAVTVRTPAPDGALVARESAHTADAAPPPRLVAYVTSPEGEAASEDALRAYVAERLPAAMVPHTVVTLPRLPLTRNGKTDHRALPDPPPRRRPRSRPFAAPRGEAETRVAQEVADVLGTGPVGRDDSFLELGGDSLQAMRLLARLRRAGSTASLRDVLRDGSPAALAAHGWREPDAAGTPARQTLPPGPRTRPLTPQQAGVYFHWRLDPDSPYYSYQGSLELDGPLDPPRLARAWQLLLGENPQLLARFTEGAEGDDGADVLHHYPHWDVPLPSHARKATAEEYRRHAAAEAGRPFDLTCEPALRAELFELPGGQHRLLVTMHELLLDGWGATVLFQRLAELYATRPQGPDPERATRYDRYLEHQRRLLDTEEVAEAGRYWSRRLAGELPVLELARKQRPATPGYHGATVEAVLDADLTRRLNETALAASATAFVPLLAAYALALGYYGDAEEVIVGAPMAGRERPEAADVPAFTLAMLPLRLRMDPDVPLAEFTAQVRETVHDAYAAADHPFGWTLRRLPAATRSSAATPVFQTMLNMLPYPARETTAAGVGFRFVELDTGYTKYDCALYVQPHGTDRLLLQYAYQRELLEAQAARDVLASTLTALRALTDPARATGTTIRSLDLLPGGEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA21</accession>
    <name>A0A2G1XA21_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malto-oligosyltrehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">treY</name>
        <name evidence="3" type="ORF">BLA24_31695</name>
        <name evidence="4" type="ORF">CYQ11_24750</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48019">
        <property type="protein sequence ID" value="PHQ48019"/>
        <property type="gene ID" value="BLA24_31695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15645">
        <property type="protein sequence ID" value="PPT15645"/>
        <property type="gene ID" value="CYQ11_24750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="9"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="806" mass="86671" checksum="5D48F4A73A1DFA9C" modified="2018-01-31" version="1">MKRERSAPPTATYRLQLQPAFPFAAAERAVPHLAALGVSHLHLSPVLEAVPGSAHGYDVVDHTTVRAELGGEEGLRALARTAHAHGLGLILDIVPNHMAVPAPERLNRPLWEVLRDGPASPFAHWFDIDWAEHGGKVLLPVLAGPLGEELERFTVTDGALRYHDHVLPLRPGTEQLPLPELLDAQWYRPAWWRLARTELNYRRFFTVSELIAVRVEDPAVFADTHAAVLALLREGVLDGLRVDHPDGLADPPGYLDRLHEATGGRWTVVEKILGGDERLPAGWPVAGTTGYDALRHLDGLFTDPEGAAELAAAYRAFTGAPPDRGGDWPSTVRRAAHRVVTRELAAEVERLARTAGRICDASHHLRDHAPWALRTALRETLVRLPVYRPYALPGRPAAPADAAMLDEAAQGARAAFAVPEEAAVVTFVRDAALGRLGDGPDHRDFCARFAQTASALRAKSVEDTAFYRYVPLLSANEVGGDPQRPAVGPAEFHAYCARLQRDWPATGTVLSTHDTKRSADVRARIAALSACPDRWTELMGRLHSAAPAPDPHVAWVAWQTAFGLGGEGAPEPARLEPALLKSVREAALWTTWTEPDTAYEEAVRAFVAAGPCGAPYGLLAPLARETGPWVRAHVLGAALLHLTMPGVPDLYMGTERVYRALVDPDNRRPPRFGDEDGGDDCADGGGGGAGLEPTGLSAAKLHLTRTALRLRRAHPEWFGPGSSYEPLTALGPAAGHCVAFARSGEVVTAVLRLPHRLAASGGPAGTAVPLPGGGAWRELLTGRTYEGRMPLSALSGEWPVALLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XA36</accession>
    <name>A0A2G1XA36_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_32070</name>
        <name evidence="3" type="ORF">CYQ11_25130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48082">
        <property type="protein sequence ID" value="PHQ48082"/>
        <property type="gene ID" value="BLA24_32070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15708">
        <property type="protein sequence ID" value="PPT15708"/>
        <property type="gene ID" value="CYQ11_25130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="276" mass="29282" checksum="9E562756FB60EA07" modified="2018-01-31" version="1">MGGERSGARAAGSYFERTGPDTYAPTSHTQGPWNPEHQHAGPTVALTTRAVEHCLATSGGDPLDVGRITCEILAPLTLAPMTVRARLERPGKRVRLVRAELGQRGRTVLTASAWAVAHAPGDLPVRSAPAAVPHRPPEGLPSVDPTRRPEWDCGFMASVEWRFADGGFGRPGPAAVWARPRIPLLAGEAVSPLQRLLLTADSANGVSAELPIDRWLSISPELTVHVARLPRGPWLCLDAETSAGPGETGLATGRLWDGEGLVARSAQCLLLAPQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAA6</accession>
    <name>A0A2G1XAA6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BLA24_32525</name>
        <name evidence="10" type="ORF">CYQ11_25575</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48152">
        <property type="protein sequence ID" value="PHQ48152"/>
        <property type="gene ID" value="BLA24_32525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15778">
        <property type="protein sequence ID" value="PPT15778"/>
        <property type="gene ID" value="CYQ11_25575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="245"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PHQ48152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PPT15778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="401" mass="44296" checksum="76BF2F0C2ED0E26F" modified="2018-01-31" version="1">MGRLARTEGLTDVQREILATVREFVDKEIIPVATELEHRDEYPTRIVEGLKELGLFGLMIPEEYGGLGESLLTYALCVEEIARGWMSVSGIINTHFIVAYMLKQHGTREQREYFLPRMATGEVRGAFSMSEPALGSDVSAITSKGVREGDEYVLTGQKMWLTNGGSSTLVAVLCRTDEGHPEGTAPHKSMTTFLIEKEPGFGQVKPGLTIPGKIDKMGYKGVDTTELIMDGLRVPADRVLGGTTGRGFYQMMDGVEVGRVNVAARGCGVAQRAFELGVTYAQQRQTFGKAIAQHQAIQFKLAEMGTKVEAAHAMMVNAARKKDSGERNDLEAGMAKYLASEYCKEVVEDAFRIHGGYGFSKEYEIERLYREAPMLLIGEGTAEIQKMIIGRRLLEEYRIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAG5</accession>
    <name>A0A2G1XAG5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_32800</name>
        <name evidence="4" type="ORF">CYQ11_25850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48201">
        <property type="protein sequence ID" value="PHQ48201"/>
        <property type="gene ID" value="BLA24_32800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15827">
        <property type="protein sequence ID" value="PPT15827"/>
        <property type="gene ID" value="CYQ11_25850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT15827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="162" mass="17556" checksum="50FE24453D9BDE7C" modified="2018-01-31" version="1">MPPSPATPATQDSESASEDRPALTRIRSLPSWLLNRASARGRRLVADALAQDGMRMPHHAVLSAVADLGPVAQAELGRTTGFDPKDMVGILNELQAQELITREPDPADRRKNAITLTEAGRRRLAHLAELGDEANEALLAALTPVERELFLALLTRIVEGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAN2</accession>
    <name>A0A2G1XAN2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ACP synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Beta-ketoacyl-[acyl-carrier-protein] synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BLA24_33345</name>
        <name evidence="6" type="ORF">CYQ11_26395</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48288">
        <property type="protein sequence ID" value="PHQ48288"/>
        <property type="gene ID" value="BLA24_33345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15919">
        <property type="protein sequence ID" value="PPT15919"/>
        <property type="gene ID" value="CYQ11_26395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="5"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PHQ48288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PPT15919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="422" mass="44627" checksum="83386E051B084339" modified="2018-01-31" version="1">MTRRVAVTGIGVVAPGGTGAAGFWDLLVQGRTATRGITLFDPAGLRSRIAAECDFDPQAHGLDQEFTERADRYVQFAVVAAEEAVRDCGLDTAAEDPWRIGVSLGTAVGGTTRLEHDYVLVSQSGRRWDVDHHRAGPQLHTAFSPSTLASVVAERFGARGPVQAVSTGCTSGLDAVGYAFHTIEEGRADVCIAGASDSPISPITMACFDAIKATSPDNDDPEHASKPFDNRRNGFVMGEGAAVLVLEDYEHARARDAHIHCEISGYATYGNAYHMTGLTTEGLEMSRAIDTALGQAGLGPTAIDYVNAHGSGTRQNDRHETAAVKLSLGAHAYDTPMSSIKSMVGHSLGAIGAIEVAACVLALKHQVVPPTANYETPDPECDLDYVPRIARPRKLRNVLSVGSGFGGFQSAVLLTRTGGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XAW3</accession>
    <name>A0A2G1XAW3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_32195</name>
        <name evidence="2" type="ORF">CYQ11_25250</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000168">
        <property type="protein sequence ID" value="PHQ48363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48363">
        <property type="protein sequence ID" value="PHQ48363"/>
        <property type="gene ID" value="BLA24_32195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16789">
        <property type="protein sequence ID" value="PPT16789"/>
        <property type="gene ID" value="CYQ11_25250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT16789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="159" mass="17515" checksum="D890D5499713C3BD" modified="2018-01-31" version="1">MVFLLIAIPAGYLYISAMQSRGGGESKQEQAAATGLEEGWPTRLQRRLYEVTVPSSAEDVAHFETNSWKSSALYLRFTTTRAKFDKWLTGVGSSAADLEDGEVTIDEDEAAEVGWEFGDGHHWAGTVHEQDKPKPTLEITANLDDPKRPKVFVVSTTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XB90</accession>
    <name>A0A2G1XB90_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29375</name>
        <name evidence="3" type="ORF">CYQ11_06100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48475">
        <property type="protein sequence ID" value="PHQ48475"/>
        <property type="gene ID" value="BLA24_29375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12527">
        <property type="protein sequence ID" value="PPT12527"/>
        <property type="gene ID" value="CYQ11_06100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="249" mass="27802" checksum="AF2741D81BFDDA7E" modified="2018-01-31" version="1">MTTFAPDSLALNRKLPLWYQVSQSLRASILGRRPDDPLRLPTEDALAEHYGVSVLTMRQALKELEAEGLISRHRRRGTFIEPSARRGSPVRLLGSVDAIVAQQSGERTAVLDHGPAPVPAQLAEHFPGLAEVTAYRRLRCEESTGEPTNWAENLIRPELAERIDLADLARWPMTKVLRDALGVRISRITDTVEARLADPETARLLQVPLLSPILHYTGVTYDETGRVVDVALIRYRGDRFSFTVTLDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBI2</accession>
    <name>A0A2G1XBI2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_29910</name>
        <name evidence="3" type="ORF">CYQ11_05560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000162">
        <property type="protein sequence ID" value="PHQ48565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48565">
        <property type="protein sequence ID" value="PHQ48565"/>
        <property type="gene ID" value="BLA24_29910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12433">
        <property type="protein sequence ID" value="PPT12433"/>
        <property type="gene ID" value="CYQ11_05560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="85" mass="9291" checksum="4417CED7A6CE42CF" modified="2018-01-31" version="1">MTIHPEHAAKAAELAELRRNLDVGVVRIDGRLALLAQRSEQAERDLCEMTERVRALEHGRWPLASLAALTGLAGLAVAVWQALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBQ8</accession>
    <name>A0A2G1XBQ8_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class II aldolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fuculose phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BLA24_28615</name>
        <name evidence="4" type="ORF">CYQ11_06850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48673">
        <property type="protein sequence ID" value="PHQ48673"/>
        <property type="gene ID" value="BLA24_28615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12646">
        <property type="protein sequence ID" value="PPT12646"/>
        <property type="gene ID" value="CYQ11_06850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="34"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PHQ48673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PPT12646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="238" mass="24982" checksum="6F13AB742C51305C" modified="2018-01-31" version="1">MRVPEEDARTARGRTGAGGPIPPGIPADLGGAWAELVASARRTTAEGLVVGTSGNVSARVGDVVLVTPSGVPYDRLGPGDAVGVDLDGRQVLGELVPTSELPMHLAVYRSTDAAAIVHTHAVHATAVSTLVDEVPLIHYMAAALGGPVRVAPYALYGSEELAAHMLAALDGRTGCLLRNHGTLTYGTTLDQAYDRTAQLEWMCRVWLAASAVPGRTPTLLTPQRLAEVTEKYRGYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBS5</accession>
    <name>A0A2G1XBS5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_28520</name>
        <name evidence="2" type="ORF">CYQ11_06950</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48660">
        <property type="protein sequence ID" value="PHQ48660"/>
        <property type="gene ID" value="BLA24_28520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12660">
        <property type="protein sequence ID" value="PPT12660"/>
        <property type="gene ID" value="CYQ11_06950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT12660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="497" mass="52388" checksum="8947A5C361B1FBC5" modified="2018-01-31" version="1">MSSDRPTMPPVRLPSDAELARDALSAPLFARAAKLARWAGEGTPVGAGGELLAGQLATATGLLGLEGDEDGPAYAAEAWQLALDTGLVEFTEGEEAADADADQPSGTAVAGEELATLTSGSPQDVLELWLAGLETVLADAATPDLGDLVEQLTDSADGQLDLDSIDWNPEEEADFLDGILGNLYLLTALDEGSAERPVPLPALAASMIVPDDMDEPTDEVLEEVSDAMMRLDDQFRMLAPTGLVTYRPVDEELIEVVDGEGHIRESVDGLASDLPEDEDVSRYGLVGLTPLGVFAVRSRMLDAGVDAPAVGDLAEAGADALLAALPHHPPSAVHTETELWLARRSPLEAARELLAAARGSDEAAPGRRLVCQQTLSLLGAEAEPALREVLDDPELGGLARVWLAEHGAADIPEPGEAMVFWLTVDTIAAQLAVEGDSEELRGLVEALAGRHSGFFETAWRVDHPATAEVLEAMGRLHPDKKLAKQARKAAFKARSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XBU2</accession>
    <name>A0A2G1XBU2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_28655</name>
        <name evidence="3" type="ORF">CYQ11_06810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000161">
        <property type="protein sequence ID" value="PHQ48680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT12639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48680">
        <property type="protein sequence ID" value="PHQ48680"/>
        <property type="gene ID" value="BLA24_28655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT12639">
        <property type="protein sequence ID" value="PPT12639"/>
        <property type="gene ID" value="CYQ11_06810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT12639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="208" mass="21462" checksum="B69757EB261D1C8D" modified="2018-01-31" version="1">MVADPWAEAVRQQLRLGRVLPLGGADEDLWISEAAVAAALRHAAAAAGLGLRVDAVRVAPARSDEPRGPSRVEVDFAAPGDLPFPRTADRLRDALAAATEDRLGLAVAVMDLRVTALLDAPAPDEAPPHAPDPAPAPADGAGRAALSVPGAARLAPALIDPRRDDWQQIAVAPGYRALDVARAVRAAVPTAVLVTAVDQPPVHPGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC39</accession>
    <name>A0A2G1XC39_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_27275</name>
        <name evidence="5" type="ORF">CYQ11_18380</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48780">
        <property type="protein sequence ID" value="PHQ48780"/>
        <property type="gene ID" value="BLA24_27275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14571">
        <property type="protein sequence ID" value="PPT14571"/>
        <property type="gene ID" value="CYQ11_18380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ48780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT14571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14413" checksum="DE7569BFE620805B" modified="2018-01-31" version="1">MGVTGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQIVDTAIQEDADAIGLSILSGAHNTLFAKVMELLRERDAADIKVFGGGIIPEEDIPPLKAQGVAAIFTPGATTTSIVEWVNANVRHPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XC99</accession>
    <name>A0A2G1XC99_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BLA24_27845</name>
        <name evidence="2" type="ORF">CYQ11_17795</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48877">
        <property type="protein sequence ID" value="PHQ48877"/>
        <property type="gene ID" value="BLA24_27845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14476">
        <property type="protein sequence ID" value="PPT14476"/>
        <property type="gene ID" value="CYQ11_17795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PPT14476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="173" mass="19835" checksum="0E98C4FD5E47D3A0" modified="2018-01-31" version="1">MSQTDLAFTDLLASTRHSAVHLEMRDSYGIGEEAAEFEAWRAGWRPSSKPGTWWNDFHTMVRDAVARGVVFRRARVVSEPVSDYIRYEHDCTYQNVAAGELVRWLPRRKASDLALPGNDFWLFDEQVIMWNHFTGDGGSAGPELDERPEVAKLCSTAFEAVWERATPHEEYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCF3</accession>
    <name>A0A2G1XCF3_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Resolvase/invertase-type recombinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27835</name>
        <name evidence="3" type="ORF">CYQ11_17805</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48875">
        <property type="protein sequence ID" value="PHQ48875"/>
        <property type="gene ID" value="BLA24_27835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14478">
        <property type="protein sequence ID" value="PPT14478"/>
        <property type="gene ID" value="CYQ11_17805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT14478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="135" mass="14369" checksum="32E5FA178ED5BEC1" modified="2018-01-31" version="1">MTPMSSAPGPDALREAVRTGECDVVVVFKLSRPTRRGAREALNSEAELREHGVSSISATERFVDTSDPTGVALIAALAEQESKSTSGFVRSAKTELRDIGSHTSGIAPYGFTTTREQRGDLVAVKLNADPVQVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG3</accession>
    <name>A0A2G1XCG3_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS alpha-glucoside transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BLA24_27900</name>
        <name evidence="16" type="ORF">CYQ11_17740</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">DSM 41675</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT14467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48885">
        <property type="protein sequence ID" value="PHQ48885"/>
        <property type="gene ID" value="BLA24_27900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT14467">
        <property type="protein sequence ID" value="PPT14467"/>
        <property type="gene ID" value="CYQ11_17740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="126"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PHQ48885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PPT14467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="487" mass="49587" checksum="5BFECA12E91C4FA3" modified="2018-01-31" version="1">MAADDHSKHRATATALLPLLGGTANLLTVTHCMTRLRVEVRDPALVRGDGLRALPGVLGVVEDAASRPAAYQIVLGPGTVARVTPELRRLAGTGTAVTAEALAERGAALRAERGARNATPLKLLLRRVAQVFVPLIPALIGCGVIAGLAGLLANLHWAPALVPALTAIAAGFMALIAVFVGHQTAKEFGGTPVLGGAVAAVIVCPGVTHVHAFGHTLSPGQGGVLGALAAALLAVAVEKWCHRRVPESVDVLLTPFLTVLLPGLVTLYGLMYAAGAVSSAIGRCADWLLTGGGAAAGFVLGGLFLPLVMLGLHQALIPIHTTLISEQGHTVLLPVLAMAGAGQVGAALAVYVRLRRNKSLRKIIRSALPAGLLGVGEPLIYGVSLPLGRPFVTACVGGAFGGGFLGLLAQLGDPVGATAIGPSGWALFPLLTGGHGLGRAVAVYGAGLLVGYAAGFLATYFFGFAGHDGERADRQMAEKHRRSEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCG7</accession>
    <name>A0A2G1XCG7_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1963 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_27115</name>
        <name evidence="1" type="ORF">BLA24_27130</name>
        <name evidence="3" type="ORF">CYQ11_18525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000156">
        <property type="protein sequence ID" value="PHQ48920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NHZO01000155">
        <property type="protein sequence ID" value="PHQ48947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT16653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48920">
        <property type="protein sequence ID" value="PHQ48920"/>
        <property type="gene ID" value="BLA24_27130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48947">
        <property type="protein sequence ID" value="PHQ48947"/>
        <property type="gene ID" value="BLA24_27115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT16653">
        <property type="protein sequence ID" value="PPT16653"/>
        <property type="gene ID" value="CYQ11_18525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PHQ48920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT16653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="303" mass="33220" checksum="BA3132E00D0CE17F" modified="2018-01-31" version="1">MTDSTSETGPLHHLARTHLPADLAERWTGLLRPAARLLATPEPGPGDVVVGRLGGLPALPENEEWPVWEGHGPLSFVASVDCAALPAHALDIPLPTEGTLSFFYFDGQIDDGDALVWPKDPDTWAGSRVVYVPAGVAVVERALPVVDDEDVEFEAYPEVPLTARVEWTAPDAWHPDFLAALRRDGHAADPAGGHPEEAQAFVEALWDRERRADHLVGGHANPVQSPVDYEIAHAYLGKDGDEVTWSDPRVAEEARKWTLLAQIDSDDDADMMWGDCGALYWLIRPEDLAALRFDRALFTMQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCL2</accession>
    <name>A0A2G1XCL2_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_22920</name>
        <name evidence="3" type="ORF">CYQ11_23155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ48962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ48962">
        <property type="protein sequence ID" value="PHQ48962"/>
        <property type="gene ID" value="BLA24_22920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15393">
        <property type="protein sequence ID" value="PPT15393"/>
        <property type="gene ID" value="CYQ11_23155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ48962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="311" mass="31137" checksum="1B41DAF8D61048FA" modified="2018-01-31" version="1">MEPLRHDDPRLIGPYTVVARLDPPDGDVPVPEDRFLARSADGDRTVLVGTALAGADAGRFAVETEGARRLIGAWSGPWFAPLTDAGEQDGLPWHACAYLPVLPLPAVLAAHGGPLPERTVRALGAALAEALLTLHSGGVAHAGLSPAAVLVTADGLRLTCFGALRAAAPAGRRHGGLPGVASGTVAPEGAAGGPPHPAGDVFALGAVLAYAATGHTVPERSELPDGLRGTVSACLAGDPAGRPRAERVLDELTGTAPAGAGASGAAPRGRSRAAALFGPGWLPGHVITALVRQSAALLAVETSLPGASPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XCZ5</accession>
    <name>A0A2G1XCZ5_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_23590</name>
        <name evidence="3" type="ORF">CYQ11_22480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49071">
        <property type="protein sequence ID" value="PHQ49071"/>
        <property type="gene ID" value="BLA24_23590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15283">
        <property type="protein sequence ID" value="PPT15283"/>
        <property type="gene ID" value="CYQ11_22480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="137" mass="14378" checksum="9A5AF399E8FC5EC6" modified="2018-01-31" version="1">MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVASGLTSLTAGASRIFEGGTVNQTVVEMERGFLFIMSVSDGSSLAVLAHPECDIGLVGYEMALLVDRAGNVLTPDLRAELQGSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD10</accession>
    <name>A0A2G1XD10_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BLA24_24060</name>
        <name evidence="3" type="ORF">CYQ11_22010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49147">
        <property type="protein sequence ID" value="PHQ49147"/>
        <property type="gene ID" value="BLA24_24060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15202">
        <property type="protein sequence ID" value="PPT15202"/>
        <property type="gene ID" value="CYQ11_22010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305492" evidence="1">
        <location>
            <begin position="26"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PHQ49147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PPT15202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="450" mass="49600" checksum="C98AE67509EA28FA" modified="2018-01-31" version="1">MRPTRPVLLVALSALALTSCGSGSGDDPDTVKVAYQRSTDNKVRIMDAYLAGIKKQFERTYQGKKLRLLPVQASQDDYYTKIQQMMRSPKTAPDLVREDTFLINADIKSGYLRPLDDKLAAWKHWDRFAASAKASARAEDGRTYGVPDGTDTRGLWFNKELFARAGLPADWRPRTWNDVLDAARAVKRAVPGVIPLNVYTGKGAGEGAAMQGFEMLLYGTGADPLYDPAAKKWRAGTTGFRDSLEFVRTVFAEKLGPQPSDALDPNVSTRVAGEWIPEGKLAIALDGSWLGKYWQPDGSRPWPQWSRVMGRAAFPTQDGRDPGRVSLSGGWTWSISARSTKADLAWQLVELLQSPENATDWTVRDGQIAVRDDVAANDRYRSSMPGVEFFTGLVKNTHYRPALPVYPQVSSAIQEAMESVTTGDASTERAARRYDERLRSIAGADGVKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XD11</accession>
    <name>A0A2G1XD11_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BLA24_23450</name>
        <name evidence="7" type="ORF">CYQ11_22620</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">DSM 41675</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49049">
        <property type="protein sequence ID" value="PHQ49049"/>
        <property type="gene ID" value="BLA24_23450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15305">
        <property type="protein sequence ID" value="PPT15305"/>
        <property type="gene ID" value="CYQ11_22620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="289"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="485"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PHQ49049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PPT15305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="734" mass="79304" checksum="B27A72DC9B511EBA" modified="2018-01-31" version="1">MGGVPALDEPLKKTLGGTTAKVMAEHLDLHTVGDLLHHYPRRYAERGELTRLADLPLDEHVTVVAQVSDARVHKFNNGRGQRLEVTLTDGSGRLQLVFFGRSIYHHQKELVPGRRGMFAGKVGTFRTTRQLSHPAYEMLGENSDADTARAWASQLIPLYPACSKMESWKVSNAVDVVLASMEAAGWDSVVDPLPAALREGRGLLPLPEAFRKVHRPRTKAEIEDARSRLKWDEAFVLQVALARRRHADSQLPAVARKPVAGGLLDAFDAKLPFTLTDGQHKVSAEIFDDLATEHPMHRLLQGEVGSGKTMVALRAMLGVVDAGGQAAMLAPTEVLAQQHHRSITETMGPLAEGGMLGGAEQGTKVVLLTGSMGAAARRQALLDLITGEAGIVVGTHALIEDKVGFHDLGLVVVDEQHRFGVEQRDALRSKGKQPPHLLVMTATPIPRTVAMTVFGDLETSVLDQLPAGRSPIATHVVPAKDKPHFLARAWERVREEVEGGHQAYVVCPRIGDEEDEAKAAKAKAEAEGERRPPLAVLDVAEQLERGPLAGLRVAVLHGRMQPEAKDDVMRRFAAGEVDVLVATTVIEVGVNVPNSTVMVIMDADRFGVSQLHQLRGRVGRGSAPGLCLLVSEAHEASPARARLGAVAATLDGFELSRIDLEQRREGDVLGQAQSGVRSSLRMLAVIDDEEIIAAAREEAAAVVAGDPELARLPALRTALDALLDKEREQFLDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDC6</accession>
    <name>A0A2G1XDC6_STRCJ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BLA24_24520</name>
        <name evidence="5" type="ORF">CYQ11_21550</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">DSM 41675</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49232">
        <property type="protein sequence ID" value="PHQ49232"/>
        <property type="gene ID" value="BLA24_24520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15117">
        <property type="protein sequence ID" value="PPT15117"/>
        <property type="gene ID" value="CYQ11_21550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033305494" evidence="2">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PHQ49232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PPT15117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000222531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000239771"/>
        </source>
    </evidence>
    <sequence length="271" mass="28516" checksum="78455BFB7F8B97D6" modified="2018-01-31" version="1">MARLMARRRNIVIAAGSLLALAGVISGTVAVATQDTDGMGGVSAQGSASPDGKGGGGASAVPSDALPSGPVSASLAHETERGGKNVALTIDDGPDPVWTPRTLAVLKQNGVKAVFCMIGPSARAHPDLVKQIVAAGHRLCDHSVDHNTAMDKRSEEYQRQQVLDAKKMIEEAAGGTAAVHYYRAPGGAFTPYSRGLSAANGMRPLGWNVDTHDWQRPGVDRIVATVKREVREGPIILFHDGGGERSQSVEALARCISWLKEEGYGFDFPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2G1XDD8</accession>
    <name>A0A2G1XDD8_STRCJ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">lon</name>
        <name evidence="13" type="ORF">BLA24_24605</name>
        <name evidence="14" type="ORF">CYQ11_21465</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces cinnamoneus</name>
        <name type="synonym">Streptoverticillium cinnamoneum</name>
        <dbReference type="NCBI Taxonomy" id="53446"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces cinnamoneus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2017" name="Biochemistry" volume="0" first="0" last="0">
            <title>Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin.</title>
            <authorList>
                <person name="Patteson J."/>
                <person name="Cai W."/>
                <person name="Johnson R.A."/>
                <person name="Santa Maria K."/>
                <person name="Li B."/>
            </authorList>
            <dbReference type="PubMed" id="29053243"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 21532</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2017-12" db="EMBL/GenBank/DDBJ databases">
            <title>Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.</title>
            <authorList>
                <person name="Vior N.M."/>
                <person name="Lacret R."/>
                <person name="Chandra G."/>
                <person name="Dorai-Raj S."/>
                <person name="Trick M."/>
                <person name="Truman A.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">DSM 41675</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="NHZO01000154">
        <property type="protein sequence ID" value="PHQ49246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PKFQ01000001">
        <property type="protein sequence ID" value="PPT15102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PHQ49246">
        <property type="protein sequence ID" value="PHQ49246"/>
        <property type="gene ID" value="BLA24_24605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="PPT15102">
        <property type="protein sequence ID" value="PPT15102"/>
        <property type="gene ID" value="CYQ11_21465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000222531">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000239771">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="605"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="695"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="738"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference t
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